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417 lines
50 KiB
Markdown
---
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type: "Reference"
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title: "Theme 5 · Robin's personal research (vendor deep reads + sales ammunition + CRM)"
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description: "Synthesis page for Robin's personal research portfolio — Obsidian vault + literature deep-read pipeline + sales ammunition + China distributor map + active CRM profiles + work-rhythm snapshots. Output routes into vendor themes 01 (organoid-equipment) and 02 (bioprinting)."
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tags: [theme, research, vault, deep-read, sales, crm, life-sciences, 2026-08-22, 2026-08-21, 2026-08-20, 2026-08-19, 2026-08-18, 2026-08-17, 2026-08-15, 2026-08-13]
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timestamp: 2026-08-22T18:13:00Z
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---
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# Theme 5 · Robin's personal research (vendor deep reads + sales ammunition + CRM)
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This is the synthesis page for **Robin 个人研究项目** — the durable body of work Robin builds on the 4-vendor product line: vendor-paper deep reads, vendor whitepaper deep reads, sales ammunition (pricing + protocols + app notes), the China distributor map, the active CRM profile set, and the weekly work-rhythm snapshot. Output is fed back into the vendor themes ([`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) and [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md)) and into `/commitments.md`.
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## What this theme covers
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- **Research identity & scope:** 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed) + adjacent application domains (MSC spheroids, PDO, brain organoids, hMOs, assembloids, 3D bioprinting, electroporation).
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- **Knowledge substrate:** Obsidian vault rooted at `/mnt/c/Users/20864/.openclaw/workspace` (per `~/.openwiki/connectors/git-repo/config.json`), HEAD `1a81e485`, ahead of origin/main by 9 commits.
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- **Research process:** LDR master template + SOP-vs-implementation lessons (Tasevska / Raji / Bosnjakovic as canonical worked examples).
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- **Research output:** 1,202 deep-read notes in `04-Literature/Deep-Reads/` + sales training material in `06-Sales/Content/Training-Materials/` + active CelVivo industrial-customers program.
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- **CRM + market research:** 1 active distributor profile (`02-Clients/Agents/董慧群.md`) + 261-dealer China map + 11+ end-customer dossiers under `03-Resources/End-Customers/`.
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- **Work-rhythm evidence:** 2026-07-16 vault mtime snapshot showing Robin's actual activity cadence across deep reads / training material / daily / weekly reports.
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## Research output — data model
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```mermaid
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erDiagram
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VAULT["Obsidian vault (a4fa5a32)"] ||--o{ DEEPREADS["Deep-read notes ~1,207"]
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VAULT ||--o{ TRAIN["Sales training (CelVivo赋能培训 v1-v9)"]
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VAULT ||--o{ SALES["Active sales pipeline (惠百生物 PO + 中间商)"]
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VAULT ||--o{ CRM["Distributor profiles (董慧群 + 待补)"]
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VAULT ||--o{ ENDCUST["End-customer dossiers (11+ 神经/中药/肿瘤所)"]
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VAULT ||--o{ INDUSTRIAL["Industrial customers (CelVivo中国工业客户开发)"]
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VAULT ||--o{ MEMORY["Daily + weekly reports (memory/ 147 .md)"]
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VAULT ||--o{ ITX["ITX 24h host build (untracked)"]
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VAULT ||--o{ MOC["MOCs (类器官与3D培养 first, +planned)"]
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VAULT ||--o{ TEMPLATES["Templates (类器官IRB申请清单 v1.0, untracked)"]
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DEEPREADS }o--|| VENDOR["Vendor mapping"]
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VENDOR ||--|{ CelVivo["CelVivo (ClinoStar / ClinoReactor)"]
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VENDOR ||--|{ ThreeBrain["3Brain (BioCAM / Accura-3D / CorePlate)"]
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VENDOR ||--|{ Cellink["Cellink (BIO X / BIONOVA X / Lumen X)"]
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VENDOR ||--|{ Femtobiomed["Femtobiomed (CellShot / TriArm / CellPick)"]
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SALES }o--|| CelVivo
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CRM }o--|| CelVivo
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ENDCUST }o--|| ThreeBrain
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INDUSTRIAL }o--|| CelVivo
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TRAIN }o--|| CelVivo
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```
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The diagram shows Robin's research substrate: a single Obsidian vault with 8 buckets of artifacts, most of which are vendor-anchored to one of the 4 product lines. Vendor-anchored output flows out of the vault and into the canonical synthesis themes (`01` CelVivo / 3Brain; `02` Cellink; with Femtobiomed as adjacent cross-sell for both).
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## Knowledge substrate: Obsidian vault
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Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08-22T18:13:00Z):
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| Field | Value |
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| --- | --- |
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| Repo path | `/home/ldw/workspace` |
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| Branch | `main` |
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| HEAD | `a4fa5a323d6dcabeb9eccad49e636ee6ba5f87a6` (**unchanged** at the 2026-08-22T18:13Z fetch — **0 new vault commits** in the 2026-08-21T18:09Z → 2026-08-22T18:13Z 24-hour window; vault is silent for the **6th consecutive fetch** after the 2026-08-17T18:09Z + 2026-08-18T18:10Z + 2026-08-19T18:08Z + 2026-08-20T18:09Z + 2026-08-21T18:09Z silent windows; **6 calendar days stale** since the last vault HEAD bump on 2026-08-16; the 2026-08-16 Quintard 2024 Nat Commun 4-commit LDR cycle + Guo 2026 Front Cell Dev Biol 3-commit LDR cycle remain the most recent vault activity) |
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| Ahead of origin/main | 20 commits new since 2026-08-03 fetch (unchanged from the 2026-08-17 + 2026-08-18 + 2026-08-19 + 2026-08-20 + 2026-08-21 + 2026-08-22 fetches) |
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| Auth | local path only — no remote, no credentials |
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| Working-tree state | dirty (23 untracked files + 2 new untracked directories — `celvivo_commercial/1331651_20260630_131201.pdf` + `templates/类器官IRB申请清单.md` — both untracked; the `Review/zhou2023_computer_vision_microfluidics.md` first-entry-in-Review/-subfolder is still-uncommitted, carrying forward from the 2026-08-13 fetch, **11-day carry-forward** at the 2026-08-22T18:13Z fetch — **9 fetches silent** on the file) |
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| Raw manifest | `~/.openwiki/connectors/git-repo/raw/2026-08-22T18-13-00-193Z/manifest.json` |
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| **Latest cluster (2026-08-16, replacing the 2026-08-12 Liang 2026 cluster)** | **Quintard 2024 Nat Commun + Guo 2026 Front Cell Dev Biol 7-commit LDR cluster** (`0fc8db24` Quintard adds file 189 lines → `290e9635` -v2 → `24c713de` -v3 → `4073abf4` -v4 → `2e6f5989` Guo adds file 170 lines → `00f824f2` -v2 → `a4fa5a32` -v3) — **net-new external evidence** (DOI 10.1038/s41598-026-42990-2, PMID 41857098, mouse liver 3-轨道 Hep-Orgs + Cho-Orgs + HSC + DAPT+Dex P1-P10 长程成熟 + TGFβ 激活体外纤维化模型) |
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| **Latest uncommitted artifact (2026-08-13 → 2026-08-22, multi-file, unchanged at the 2026-08-22T18:13Z fetch)** | `04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md` (carry-forward untracked from 2026-08-13, now at **11-day carry-forward** at the 2026-08-22 fetch — file mtime `2026-08-11 16:31:54 +0800` so mtime-based carry-forward is 11 days; first-observation-date-based carry-forward is 9 days; **structural signal continuing to weaken** per `/sources/git-repo.md` Notable-entity entry — 9 consecutive fetches silent on the file; subfolder is more likely a one-off than a recurring pattern) + **2 new untracked directories added at the 2026-08-17 fetch**, still-uncommitted at the 2026-08-22 fetch (**6-day carry-forward** each — was 5-day at the 2026-08-21 fetch): `celvivo_commercial/1331651_20260630_131201.pdf` (6-30 quote PDF migrated into new folder) + `templates/类器官IRB申请清单.md` (180-line IRB application checklist derived from Guo 2026; Robin's first customer-facing template produced from a single deep-read — see the new Templates subtree below) |
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### Vault navigation index (top-level folders)
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| Dir | Purpose | Size hint |
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| --- | --- | --- |
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| `01-Active-Sales/` | Active sales pipeline (board + per-account) | 6 .md |
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| `02-Active-Deals/` | Deal-level active docs | 1 .md |
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| `02-Clients/`, `02-Contacts/` | Client & contact records | sparse |
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| `03-Product/` | Product briefs (e.g. 3Brain-Maxwell comparison) | 1 .md |
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| `03-Resources/Agents/` | Distributor / agent profiles | a handful |
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| `03-Resources/End-Customers/` | End-customer dossiers (3Brain MEA accounts, etc.) | 11+ .md |
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| `03-Resources/ITX-24h-Host/` | Personal 24h Hermes-Agent host build config (2026-07-31 untracked) | 1 .md |
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| `04-Literature/` | Paper deep-reads + curated vendor PDFs | see breakdown below |
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| `05-Documents/Contracts/` | Signed/pending contracts (Celvivo subfolder) | — |
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| `05-Documents/Products/` | Vendor-facing product docs (Celvivo/Industrial-Customers) | — |
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| `05-Documents/{Proposals,Quotes,Visit-Plans}/` | Active commercial docs | — |
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| `05-Products/` | In-house product briefs (MappingLab family) | 2 .md |
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| `06-Sales/Competitors/` | Competitor tracking | — |
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| `06-Sales/Configurations/` | Product configurations | — |
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| `06-Sales/Content/{FAQ,Pain-Points,PPT-Scripts,Success-Stories,Training-Materials,推文模板}/` | Sales content library | — |
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| `06-Sales/{Price-List,Product-Mapping,Recommendation-Engine}/` | Sales tooling | — |
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| `99-Templates/` | Reusable Obsidian templates | 14 .md |
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| `memory/` | Daily reports, weekly digests, `.dreams`, archive | 147 .md |
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### `04-Literature/Deep-Reads/` breakdown
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| Subfolder | .md count | Vendor / scope |
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| --- | ---: | --- |
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| `Organoid/` | 661 (+2 from 2026-08-16 — Quintard 2024 Nat Commun microfluidic vascularized organoid chip + Guo 2026 Front Cell Dev Biol organoid ethics systematic review) | broad organoid literature |
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| `Celvivo/` | 142 | CelVivo vendor + CelVivo-adjacent papers |
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| `3Brain/` | 136 | 3Brain vendor + 3Brain-adjacent papers |
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| `Cellink/` | 129 | Cellink vendor + Cellink-adjacent papers |
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| `Organoid-List/` | 51 | curated organoid reading lists |
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| `Product-Reports/` | 38 | vendor product reports |
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| `Brain/` | 11 | brain organoid focus |
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| `Brain-Tumor/` | 9 | brain tumor organoid |
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| `Cancer/` | 6 | cancer organoid |
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| `Liver/` | 7 | liver organoid / HepG2 (Liang 2026 4-commit LDR cycle 2026-08-12) |
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| `Other/` | 6 | uncategorised |
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| `RegenMed/` | 1 | Ronawk Bio-Block MSC 4-week (added 2026-07-28) |
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| `3Brain MEA/` | 3 | 3Brain HD-MEA papers |
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| `Cardiac/` | 2 | cardiac organoid |
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| `Kidney/` | 2 | kidney organoid |
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| `Retinal/` | 1 | retinal organoid |
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| `Microbioreactor/` | 1 | Rosero 2026 Front Bioeng Biotechnol (added 2026-08-07) |
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| `Cells/` | 1 | Fernandez Vallone 2026 Cells THSDC (added 2026-08-08) |
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| `Review/` | 1 | Zhou 2023 computer vision + microfluidics (added 2026-08-13, **untracked**, **10-day carry-forward** at 2026-08-21 fetch (was 9-day at 2026-08-20) — **8 fetches silent** — structural signal continuing to weaken; **11-day carry-forward** at 2026-08-22 fetch — **9 fetches silent**) |
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| `Templates/` | 1 | `类器官IRB申请清单.md` v1.0 (2026-08-16, derived from Guo 2026 ethics deep-read, **untracked**; first customer-facing template produced from a single deep-read; **5-day carry-forward** at 2026-08-21 fetch — was 4-day at 2026-08-20; **6-day carry-forward** at 2026-08-22 fetch) |
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| `CelVivo-commercial/` | 1 | `1331651_20260630_131201.pdf` (2026-06-30 quote PDF migrated into new folder 2026-08-17, **untracked**; **5-day carry-forward** at 2026-08-21 fetch — was 4-day at 2026-08-20; **6-day carry-forward** at 2026-08-22 fetch) |
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Total ≈ 1,206 deep-read notes on `main` + **1 untracked entry in the new `Review/` subfolder** (`zhou2023_computer_vision_microfluidics.md`, 2026-08-13 — first review-type subfolder; future-commit candidate) + **2 new untracked directories** (`templates/类器官IRB申请清单.md` + `celvivo_commercial/1331651_20260630_131201.pdf`, 2026-08-17). The 4 vendor subfolders (Celvivo / 3Brain / Cellink / Organoid) cover the canonical product KB per the wiki goal focus areas. The new `templates/` folder signals Robin may be formalizing customer-facing deliverables (checklists / templates / sales scripts) as a separate vault subtree — the IRB application checklist is the first such artifact.
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## Literature deep-read (LDR) pipeline
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The 4-27 SOP (referenced from `/sources/ldr-report-template.md` and `/sources/2026-07-27-4-27-sop-vs-implementation.md`) is the canonical research workflow Robin uses to convert a vendor-paper PDF into a publishable, indexed, cross-system deep read.
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```mermaid
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stateDiagram-v2
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[*] --> PubmedVerify: Id / DOI / PMID / PDF
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PubmedVerify --> PDFPull: PubMed eSummary 验真
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PDFPull --> ImgExtract: ragflow_direct_download.py / direct path
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ImgExtract --> VisionReview: PyMuPDF xref dedup + 30KB + p1 logo
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VisionReview --> ReportWrite: Ollama qwen2.5vl:7b (降级 if 服务宕)
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ReportWrite --> SeaFileUpload: 5 段模板 (做了什么 / 3 发现 / 4 维对接 / 局限 / 转发语)
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SeaFileUpload --> WikiPublish: PDF + 3 真图 → ?dl=1
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WikiPublish --> NocoDB: GraphQL 5-orderBy union
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NocoDB --> Commit: NocoDB v1 + JSON body (PATCH preferred)
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Commit --> [*]: OpenWiki git commit + Gitea push
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note right of VisionReview
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2026-07-17 起 Ollama 服务宕
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视觉审核降级 → 人工肉眼
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end note
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note right of NocoDB
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Cellink 库 "已精读" SingleSelect options=[]
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PATCH 失败, 在精读摘要里写
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end note
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```
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The state diagram shows the canonical LDR pipeline: PDF → images → report → SeaFile → Wiki.js → NocoDB → commit. Two known operational degradations are called out: the Ollama visual-review step falls back to human review since 2026-07-17 (see [`/themes/04-local-llm.md`](/themes/04-local-llm.md)), and the Cellink library `已精读` SingleSelect is a NocoDB bug that blocks PATCH (workaround documented in the SOP-vs-implementation file).
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### LDR SOP — 8 铁律 + 3 trigger modes + 5-section report
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From [`/sources/ldr-report-template.md`](/sources/ldr-report-template.md) (Robin 7-27 实战版):
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| 铁律 | 出处 | 实操 |
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| --- | --- | --- |
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| 1. PDF 全文必传 (SeaFile 永久链接, `?dl=1` 后缀) | 7-27 教训 | `upload.py` 上传 PDF, `?dl=1` 写 link |
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| 2. PyMuPDF xref 去重 + 30KB 过滤 + p1 logo 剔除 | 7-27 教训 (Tasevska p1 logo) | `extract_image(xref)` per page, MD5 dedup |
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| 3. 9 项强制 + 创新点/局限性/学术启示 3 段 | 7-27 教训 (2 篇缺 3 段) | 模板 §3 |
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| 4. SeaFile URL hostname `fb.biokingdom.top` | 7-27 教训 (5 URL 错) | 验证 share-link 真能开 |
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| 5. NocoDB v1 + JSON body (范本 v2 失败 3 次) | 7-27 Tasevska 入库 | `POST /api/v1/db/data/wzg1wtad/p2z4g0s687axyvu/{table_id}` |
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| 6. 3 张真图 `![]()` (SeaFile URL), 不**只**文字图说啥 | 7-27 教训 | markdown image syntax (`alt text` + parenthesized URL) |
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| 7. 报告路径 `journal-year-topic` (4-27 SOP 范本) | 7-27 教训 | `ejps-2025-hctz-sse-3d-printing` 风格 |
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| 8. 精简 4 步 vs 完整 8 步按 Robin 信号自动判断 | 7-27 实战 | 模板 §2 |
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**3 trigger modes:**
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| Robin says | I take | 耗时 |
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| --- | --- | --- |
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| "精读吧" (any PDF, no publish intent) | **精简 4 步** (PDF → PyMuPDF → 写报告 → Obsidian) | 20-30 min |
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| "A" / "发 wikijs" / "SeaFile 永久" / "入库" / "NocoDB" | **完整 8 步** (精简 4 步 + Ollama 视觉 + SeaFile + Wiki.js + NocoDB) | 45-60 min |
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| "X 还是 Y" / "你定" / "继续下一篇" | **自动** | — |
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**5-section report template (800–1500 chars):** 1. 做了什么 / 2. 3 关键发现 (每发现 3 段式表) / 3. 4 维产品对接 (CelVivo / 3Brain / Cellink / Femtobiomed) / 4. 局限 / 5. 转发语 + 落款 + PDF.
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### Worked examples (canonical deep reads)
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| Deep read | Vendor | Path | Synthesized at |
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| --- | --- | --- | --- |
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| Bosnjakovic 2025 bioRxiv | CelVivo | `04-Literature/Deep-Reads/Celvivo/Bosnjakovic_2025_PAH_3D_spheroid_CelVivo_ClinoStar_2026-07-27.md` | [`/sources/literature-cel-bosnjakovic-2025-pah-deepread.md`](/sources/literature-cel-bosnjakovic-2025-pah-deepread.md) |
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| Raji 2026 Mol Psychiatry | 3Brain | `04-Literature/Deep-Reads/3Brain/Raji_2026_hMOs_dopaminergic_3Brain_MEA_2026-07-27.md` | [`/sources/literature-raji-2026-deepread.md`](/sources/literature-raji-2026-deepread.md) |
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| Tasevska 2025 EJPS | Cellink | `04-Literature/Deep-Reads/Cellink/Tasevska_2025_HCTZ_3D_printed_extended_release_2026-07-27.md` | [`/sources/literature-tasevska-2025-deepread.md`](/sources/literature-tasevska-2025-deepread.md) |
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| CelVivo 2026 brain organoid whitepaper (16 pp) | CelVivo | under `04-Literature/Deep-Reads/Celvivo/` | [`/sources/literature-celvivo-brain-whitepaper-2026.md`](/sources/literature-celvivo-brain-whitepaper-2026.md) |
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| Hodge 2025 RegenMed | Ronawk Bio-Block (KB 0 命中) | `04-Literature/Deep-Reads/RegenMed/2026-07-28_Hodge_2025_RegenMed_MSC_3D_Bio-Block.md` | (not yet synthesized to `/sources/`) |
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| Lee 2025 Front Vet Sci | (no vendor) | `04-Literature/Deep-Reads/Other/2026-07-28_Lee_2025_FrontVetSci_canine_MSC_3D_spheroid.md` | (not yet synthesized) |
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| Parate 2020 SCRT | (no vendor) | `04-Literature/Deep-Reads/Other/2026-07-28_Parate_2020_SCRT_PEMF_MSC_paracrine_cartilage.md` | (not yet synthesized) |
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| Sharma 2026 Cell Stem Cell (2026-08-08 flywheel-sync) | 3Brain + CelVivo adjacent | `/home/ldw/workspace/retinal_organoid_deep_read_2026-08-07.md` | [`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`](/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md) |
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| Miao 2025 Cell v2 (2026-08-08 flywheel-sync) | CelVivo (ClinoStar rating 5) | `/home/ldw/workspace/Miao2025_Cell_v2.md` | [`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`](/sources/literature-miao-2025-cell-vascularization-v2-deepread.md) |
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| Liu 2026 Nat Biomed Eng (2026-08-08 flywheel-sync) | 3Brain (HD-MEA rating 5) + Cellink (microlattice rating 5) | `/home/ldw/workspace/Liu2026_NBME_shape_conformal_organoid.md` | [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md) |
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| Quintard 2024 Nat Commun (2026-08-16 vault LDR cluster) | CelVivo (ClinoStar rating 3 upstream) + Mimetas OrganoPlate (rating 4 direct) + Emulate Organ-Chip (rating 3) | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` | (not yet synthesized to `/sources/`) |
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| Guo 2026 Front Cell Dev Biol (2026-08-16 vault LDR cluster) | CelVivo (ClinoStar rating 4 clinical-translation IRB) + Mimetas OrganoPlate (rating 4 co-culture ethics) + Emulate Organ-Chip (rating 3) | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` | (not yet synthesized to `/sources/`; derived customer-facing template at `templates/类器官IRB申请清单.md` v1.0) |
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## Recent 30-day research output (mtime 2026-06-16 → 2026-08-12)
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From [`/sources/literature.md`](/sources/literature.md) last sync, broken out by vendor and date:
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| Date | DOI / slug | Vendor | Topic |
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| --- | --- | --- | --- |
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| 2026-08-16 | **Quintard 2024 Nat Commun + Guo 2026 Front Cell Dev Biol 7-commit LDR cluster** (commits `0fc8db24` + `290e9635` + `24c713de` + `4073abf4` Quintard + `2e6f5989` + `00f824f2` + `a4fa5a32` Guo) | **CelVivo adjacent + Mimetas OrganoPlate ⭐⭐⭐⭐ + Emulate Organ-Chip ⭐⭐⭐** (Quintard) / **CelVivo ClinoStar ⭐⭐⭐⭐ + Mimetas OrganoPlate ⭐⭐⭐⭐ + Emulate Organ-Chip ⭐⭐⭐** (Guo) | Quintard C et al. (2024) A microfluidic platform integrating functional vascularized organoids-on-chip (Nat Commun DOI 10.1038/s41467-024-45710-4, Wiki ID 1719/1720/1722, NocoDB Id 3297; 10 通道并行微流控 + hiPSC-BVO 30 天功能性灌注培养 + 跨类器官验证 [间充质球体 / BVO / 胰岛球体 / 肺类器官]; 血管层级化 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管, 壁剪切 27-2000 s⁻¹, 完美匹配人体毛细血管生理范围 50-1900 s⁻¹) + Guo Z & Zhang N (2026) Ethical review key considerations for organoid applications in biomedical research—a systematic review (Front Cell Dev Biol DOI 10.3389/fcell.2026.1721946, Wiki ID 1724, NocoDB Id 3298; 嘉兴市第一医院 + 嘉兴大学医学院视角; 类器官研究 IRB / 伦理审查 7 大强制要点系统综述 [样本来源/知情同意/数据隐私/共培养主体性/3R 动物福利/跨境监管/长期保存与终止使用] + 中国《人类遗传资源管理条例》+ 国际 ISSCR/GDPR/HIPAA 多国对照表). **Robin translated Guo 2026 into a customer-facing IRB application checklist template** (`templates/类器官IRB申请清单.md` v1.0 180 lines) — first customer-facing template produced from a single deep-read. |
|
||
| 2026-08-12 | **Liang 2026 liver organoid fibrosis platform 4-commit LDR cycle** (commits `e542c977` + `8699a154` + `aacba7aa` + `297f106d`) | **CelVivo (ClinoStar rating 5 + ClinoReactor rating 5)** | Liang Y et al. (2026) A robust mouse liver organoid platform enables sustained multicellular maturation and fibrosis modeling from a single tissue sample (Sci Rep DOI 10.1038/s41598-026-42990-2, PMID 41857098; Wiki.js Id 1716, NocoDB Id 770; 3 轨道 Hep-Orgs + Cho-Orgs + HSC 同步分离; DAPT+Dex P1-P10 长程稳定成熟 [ALB/PAS/LDL/CYP 跨代保持]; TGFβ 激活 qHSC → aHSC [Acta2/Col1a1 上调]; aHSC 共培养诱导 Hep-Orgs EMT [Snail/Twist/Vimentin↑; ALB/CK8↓; Lgr5/EpCAM↓; Ki67↓] = 体外肝纤维化模型) — page 946 9 项 SOP 重写版 + page 934 修齐 标杆; 7/7 Ollama qwen2.5vl 视觉审核通过; SeaFile 7/7 公网 200 验真. First paper whose `related:` field already names `[[MOC-类器官与3D培养]]` (the 2026-08-10 first MOC) on the day of publication. |
|
||
| 2026-08-10 | **Phase A metadata batch + first MOC** (commits `d97b39ed` + `6b717aef` + `3b929c2f`) | (process discipline) | 6 deep-reads received the 6-field frontmatter (doi/journal/year/volume/pages/authors/pmid); first MOC `MOC-类器官与3D培养.md` (95 lines, 沙牛《AI 时代的 Obsidian 公开课》课时 1 pattern) created at `04-Literature/Deep-Reads/MOCs/`; 7 image alt descriptions added on `wang2024-org-on-chip.md`. No new external evidence. |
|
||
| 2026-08-09 | `10.7150/thno.90492` (Wang 2024) | (4 类共性硬件 — Organoid-on-Chip 综述) | Wang H et al. (2024) Human organoids-on-chips for biomedical research and applications (Theranostics 14(2):788-818, PMID 38169573; 7 图覆盖 7 大主题板块) — Wiki.js ID 1700 (v2 - grp:3 ghost page 累加) |
|
||
| 2026-08-08 | `10.3390/cells15110963` (Fernandez Vallone 2026) | (NAMs adjacent, hiPSC brain organoid) | THSDC chemical evaluation platform using hiPSC brain organoids (Cells, v2 5 张真图 + 双 H1; Wiki.js Id 1698) |
|
||
| 2026-08-08 | `10.3389/fbioe.2026.1854988` (Rosero 2026) | CelVivo + Cellink + FemtoBiomed adjacent | Microbioreactor design Mini Review (Front Bioeng Biotechnol; 6× productivity vs T-flask; 4 applications: CAR-T / mAb / iPSC / organoid) |
|
||
| 2026-08-08 | `10.1038/s41551-026-01620-y` (Liu 2026) | 3Brain (HD-MEA rating 5) + Cellink (microlattice rating 5) | Shape-conformal porous framework for full-coverage neural organoid e-phys — Rogers Lab, Nat Biomed Eng |
|
||
| 2026-08-08 | `10.1016/j.cell.2025.05.041` (Miao 2025 v2) | CelVivo (ClinoStar rating 5) | Co-development mesoderm+endoderm for vascularized lung/gut organoids (Cell v2) |
|
||
| 2026-08-08 | `10.1016/j.stem.2025.12.013` (Sharma 2026) | 3Brain (HD-MEA rating 4) + CelVivo (ClinoStar rating 3) | Vascularized retinal organoid RGC survival (Cell Stem Cell) |
|
||
| 2026-08-06 | `10.1038/s41467-024-44732-2` (Parfitt 2024) | CelVivo + 3Brain adjacent | DJ1 LOF midbrain organoid PD model — α-syn via astrocyte lysosomal degradation (Nat Commun, untracked) |
|
||
| 2026-07-29 | Organoids for disease modeling and treatment 2026 综述 (PMID 41545895, PMC12828948) | review | Exp Hematol Oncol 2026 — 190 项临床试验 + 4 大瓶颈 |
|
||
| 2026-07-28 | `10.1080_17460751.2025.2572177` (Hodge 2025) | Ronawk Bio-Block | MSC longevity 4-week comparison |
|
||
| 2026-07-28 | `10.3389/fvets.2025.1500267` (Lee 2025) | (no vendor) | canine adipose MSC 3D spheroid |
|
||
| 2026-07-28 | `10.1186_s13287-018-1085-9` (Komatsu 2018) | CelVivo + Cellink | Type I collagen + YAP/TAZ |
|
||
| 2026-07-28 | `10.1186_s13287-020-1566-5` (Parate 2020) | (no vendor) | PEMF potentiate MSC paracrine cartilage |
|
||
| 2026-07-27 | `Raji_2026_hMOs` | 3Brain | hMOs dopaminergic + HD-MEA |
|
||
| 2026-07-27 | `Tasevska_2025_HCTZ` | Cellink | SSE-printed HCTZ extended-release |
|
||
| 2026-07-17 | `260528_CS_vs_OS` appnote | CelVivo | ClinoStar vs Orbital Shaker shear stress |
|
||
| 2026-07-17 | `111_Planimetry` appnote | CelVivo | FIJI planimetry on ClinoReactor |
|
||
| 2026-07-05 | `10.1002_btpr.2528` | CelVivo | Spheroid dissociation device |
|
||
| 2026-06-25 | `10.1016_j.stemcr.2025.102646` | CelVivo | High-throughput microfluidic organoid-on-a-chip |
|
||
| 2026-06-24 | `10.1021_acsomega.5c02682` | 3Brain | rotating human melanoma cell culture |
|
||
| 2026-06-24 | `10.1016_j.xpro.2025.103923` | CelVivo | Lung Tumoroids protocol |
|
||
| 2026-06-23 | `10.1002_jbm4.10792` | CelVivo | microfluidic organoid-on-a-chip (v2-munir2023) |
|
||
| 2026-06-23 | `10.3390_cells11203216` | CelVivo | NAFLD mapping proteome/lipidome |
|
||
|
||
By vendor (30-day mtime):
|
||
|
||
| Vendor | Most recent | 2026-08-08 / 2026-08-10 / 2026-08-12 / 2026-08-16 additions |
|
||
| --- | --- | --- |
|
||
| CelVivo | 2026-08-12 (Liang 2026 — ClinoStar rating 5 + ClinoReactor rating 5) | +Liang 2026 (P1-P10 长程成熟 + 单组织 3 轨道分通道灌流 + TGFβ 时间程序精确切换 — liver organoid fibrosis platform), +Miao 2025 v2 (ClinoStar co-differentiation), +Sharma 2026 (ClinoStar rating 3 adjacent), +Liu 2026 (ClinoStar rating 4 adjacent), +Quintard 2024 (CelVivo ClinoStar rating 3 — upstream workflow step: BVO day 0-15 needs rotating-wall suspension culture), +Guo 2026 (CelVivo ClinoStar rating 4 — clinical-translation IRB compliance for 三甲医院 客户) |
|
||
| 3Brain | 2026-08-08 (Liu 2026 — HD-MEA rating 5) | +Liu 2026 (shape-conformal framework, next-gen HD-MEA), +Sharma 2026 (HD-MEA rating 4 adjacent), +Shin 2024 (Phase A frontmatter hygiene on existing note), **−3Brain reference removed from Quintard 2024 -v4 (per commit `4073abf4` — "精读 Quintard 2024 -v4 (转发语标题/落款加粗/删3Brain)" was the explicit SOP rule "硬门槛合规修正" cleanup; Quintard is vendor-adjacent CelVivo/Mimetas/Emulate rather than 3Brain territory)** |
|
||
| Cellink | 2026-07-27 (Tasevska 2025) | +Liu 2026 (microlattice fabrication rating 5 adjacent), **+Quintard 2024 (microfluidic organ-on-chip adjacent, no direct Cellink rating — but the platform architecture is a candidate cross-sell with Cellink BIO X for vascularized scaffold fabrication)** |
|
||
| Adjacent (no vendor) | 2026-08-08 (Sharma 2026 retinal vascularization) | +Sharma 2026 (retinal organoid application domain) |
|
||
| (Process discipline) | 2026-08-10 (Phase A batch + first MOC) | +6 deep-reads received 6-field frontmatter; +first MOC `MOC-类器官与3D培养.md` created; +7 image alt descriptions on Wang 2024 — no new external evidence |
|
||
| (Subfolder expansion, uncommitted) | 2026-08-13 (new `Review/` subfolder) | +1 untracked file `Review/zhou2023_computer_vision_microfluidics.md` (first review-type subfolder — review papers stream separately from original research) |
|
||
| (Customer-facing template, uncommitted) | 2026-08-16 (new `templates/` subfolder + IRB application checklist v1.0) | +1 untracked file `templates/类器官IRB申请清单.md` 180 lines (Guo 2026 ethics deep-read → IRB checklist template; 7 mandatory points + 5 customer Q&A + China vs International flow + 10 attachments + 7 citations; Robin's first customer-facing template produced from a single deep-read; will route into CelVivo industrial-customers program once committed) |
|
||
| (Commercial quote PDF, untracked) | 2026-08-17 (new `celvivo_commercial/` subfolder) | +1 untracked file `celvivo_commercial/1331651_20260630_131201.pdf` (6-30 quote PDF migrated into a new folder; companion to the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree) |
|
||
|
||
The pipeline is **vendor-balanced** — CelVivo, 3Brain, Cellink each have a recent deep read, and the 2026-08-08 flywheel-sync adds **3 papers spanning all 3 primary vendors + the retinal organoid application domain** (Sharma), all 3 rated 4-5 on at least one vendor's product line. The 2026-08-10 cluster is **process discipline** (Phase A metadata batch + first MOC creation + Wang 2024 alt-description sample), not new external evidence — the 6 deep-reads already existed on `main`; the 3 commits only normalize their metadata and add a knowledge-graph index layer. The 2026-08-12 cluster adds **net-new external evidence**: Liang 2026 Sci Rep liver organoid fibrosis platform (4-commit LDR cycle on a single paper, CelVivo ClinoStar ⭐⭐⭐⭐ + ClinoReactor ⭐⭐⭐⭐); this is the **first paper on `main` whose `related:` field already names `[[MOC-类器官与3D培养]]` on the day of publication**, confirming the MOC pattern is in active use on real deep-reads (vs the prior 2026-08-10 "MOC `related:` lists future MOCs" framing which was only prospective). The **first entry in the new NocoDB table `Robin_Picked_Papers`** is Liu 2026 (created 2026-08-08 per Robin instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage). The **first MOC** `MOC-类器官与3D培养.md` is the start of a Map-of-Content layer Robin appears to be building (the MOC's own `related:` already names `[[MOC-3Brain-HD-MEA]]` as the next planned MOC). The 2026-08-13 cluster (no vault commits, 1 new untracked file) **adds a new `Review/` subfolder to the deep-read tree** — Robin appears to be expanding the folder taxonomy to separate review-type papers from original-research papers; whether this is a one-off subfolder or the start of a recurring folder pattern is a watchlist item for the next git-repo fetch. **The 2026-08-16 cluster (Quintard 2024 + Guo 2026) is the largest single-window vault delta since the 2026-07-28 / 2026-07-29 cluster** — 7 new vault commits spanning 2 new paper deep-reads, 2 new untracked working-tree directories, and 1 customer-facing sales-ammunition template derived from a single deep-read. The Quintard 2024 microfluidic / organ-on-chip platform (CelVivo ClinoStar upstream + Mimetas OrganoPlate direct competitor + Emulate Organ-Chip) extends Robin's vendor mapping into the organ-on-chip product lane that his portfolio doesn't currently cover; the Guo 2026 organoid ethics systematic review (7 mandatory points + 5 jurisdiction comparison) introduces the IRB / ethics domain to Robin's deep-read set and spawned `templates/类器官IRB申请清单.md` (180 lines, Robin's first customer-facing template) as the canonical "Robin 培训客户 IRB 申请" core material. The new `templates/` + `celvivo_commercial/` directories appear alongside the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree — Robin may be formalizing customer-facing deliverables (checklists / templates / sales scripts) as a separate vault subtree. The `Review/zhou2023_computer_vision_microfluidics.md` carry-forward untracked file is still-uncommitted at this fetch (now 4 days past the 2026-08-13 first observation); the watchlist trigger is if it remains uncommitted at the next fetch.
|
||
|
||
## Sales ammunition pipeline
|
||
|
||
Robin maintains a working sales library that consumes LDR output and routes into the `/sources/sales-ammunition.md` page:
|
||
|
||
- **Pricing + SKUs:** Demo kit `10005-6` lists at €300 (Global Distributor Price, with special discount); `10004-12` ClinoReactor 12-pack; `30003` ClinoStar; `SP5D-24W` low-adherence plate. Pricing source: `Exhibit 1_Celvivo Price Book 2026_Global_Distributior.xlsx` (RAGFlow KB full-text).
|
||
- **8 ClinoReactor Protocols:** 003 (prepare) / 004 (media change) / 006 (gardening) / 009 (plate config) / 010 (ClinoReactor prepare) / 012 (rotation speed — core selling point) / 014 (alginate embed) / 015 (VitroGel embed).
|
||
- **5 application notes by organ:** HepG2/C3A liver / FTC-133 thyroid / NCI-H69V SCLC / TNBC / ClinoStar vs Orbital Shaker.
|
||
- **5 brand / whitepapers:** Brochure 2026 update_for print + _online version / Cancer White Paper 2026 / 2026.04.01.715868v1 (biorxiv 2026 preprint) / ijms-24-13506-v2.
|
||
- **8 commercial docs:** Exhibit 1 Price Book / Exhibit 3 SuperUser certification / Huibai demo discount agreement / 惠百 PO 盖章版 / Celvivo Distribution Agreement 2026 Huibai Bio / 1331651_20260630_131201 (6-30 quote) / Packing Slip Ordre 726_1 / Packing Slip Ordre 726_2.
|
||
|
||
Cross-link to the canonical synthesis: [`/sources/sales-ammunition.md`](/sources/sales-ammunition.md).
|
||
|
||
**2026-08-16 addition — `templates/类器官IRB申请清单.md` v1.0** (180 lines, Robin 8-16 实战沉淀, **untracked**; derived from Guo 2026 Front Cell Dev Biol IRB / ethics systematic review — Wiki.js ID 1724, NocoDB Id 3298). The IRB application checklist is **Robin 第一份 customer-facing template produced from a single deep-read** and consists of: (a) **7 强制要点** [样本来源合法性 + 捐赠者知情同意 + 数据隐私与去标识化 + 共培养产物主体性评估 + 动物福利 3R + 跨境监管合规 + 长期保存与终止使用]; (b) **5 customer Q&A** [类器官研究是否要 IRB 申请 / 类器官共培养产品怎么申请 IRB / 类器官跨境研究怎么报 / 3R 原则怎么写 / 类器官 + 免疫细胞共培养 = CAR-T 体外培养, 算不算新生物体]; (c) **China vs International flow comparison table** [中国 2023 新规 vs 美国 Common Rule vs 欧盟 GDPR]; (d) **10 申请附件清单** [IRB 申请表 + 知情同意书 + 研究方案 + DMP + 样本采集机构 IRB 批件 + ...]; (e) **7 引用** [Guo 2026 + ISSCR 2021 + OHRP 2016 + GDPR + 中国 2023 + 中国 2019 + Cambridge 2020]. **Vendor relevance**: CelVivo ClinoStar ⭐⭐⭐⭐ (the 7 mandatory points directly apply to ClinoStar customer IRB submissions; **Robin 推广 ClinoStar 给三甲医院时, 可附带本框架作为增值**). Tracks as `/commitments.md` `guo-2026-organoid-irb-checklist-rollout` (Owner: me; fold IRB application checklist into CelVivo industrial-customers program + Robin customer-training core material; commit `templates/类器官IRB申请清单.md` and add a synthesis page at `/sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md`).
|
||
|
||
## Sales training cluster (working-tree additions)
|
||
|
||
Per `/sources/git-repo.md` §"Notable entities", `06-Sales/Content/Training-Materials/` contains the following working-tree additions not yet on `main`:
|
||
|
||
- `CelVivo_销售培训_PPT_v9_给销售看版.pptx` (3.9 MB, 06-26 14:13) — latest PPT
|
||
- `CelVivo_Robin老师逐字稿_v6_深度版_20260626.md` (63 KB, 06-26 13:45) — latest verbatim script
|
||
- `CelVivo_销售培训_讲义_v2_20260626.md` (13 KB, 06-26 12:14) — latest handout
|
||
- `Robin稿生成通字稿` family (v3–v6) and `CelVivo赋能培训` family (v1–v9, depth-flavored edits)
|
||
- `销售基础话术包` pair
|
||
|
||
The version progression is `基础 → 5大管线 → 深度版 → 终稿修正 → 销量仅看` — the cluster is iterated in place, not committed. See [`/sources/vault-mtime-snapshot-2026-07-16.md`](/sources/vault-mtime-snapshot-2026-07-16.md) for the latest mtime census (CelVivo_销售培训_PPT_v9 = 2026-06-26 14:13).
|
||
|
||
## China distributor map (259 dealers across 7 regions — 2026-08-07 baseline)
|
||
|
||
From [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) (Hermes整理, 2026-08-07; **replaces 2026-07-24 baseline of 261 dealers**):
|
||
|
||
| Region | 8-07 count | 7-24 count | Δ | Share | Main city |
|
||
| --- | ---: | ---: | ---: | ---: | --- |
|
||
| 华北 | 72 | 74 | -2 | 27.8% | 北京 (54) |
|
||
| 华东 | 68 | 68 | 0 | 26.3% | 上海 (53) |
|
||
| 华南 | 62 | 62 | 0 | 23.9% | 广州 (44) |
|
||
| 山东 | 25 | 25 | 0 | 9.7% | 济南 (22) |
|
||
| 湖北 | 19 | 19 | 0 | 7.3% | 武汉 (12) |
|
||
| 西北 | 6 | 6 | 0 | 2.3% | 西安 (6) |
|
||
| 西南 | 7 | 7 | 0 | 2.7% | 重庆 (3) |
|
||
| **TOTAL** | **259** | **261** | **-2** | 100% | — |
|
||
|
||
Brand keyword map (top 20 by 全国 count): BI 19 / Thermo 19 / Bio-Rad 11 / 赛默飞 8 / 安捷伦 7 / 蔡司 6 / Cytiva 6 / 伯乐 6 / 徕卡 6 / 赛多利斯 5 / Eppendorf 5 / Leica 5 / Beckman 4 / Merck 4 / Waters 4 / Azure 3 / Bruker 3 / Oxford Nanopore 3 / Agilent 3 / Sartorius 3.
|
||
|
||
**8-07 独有产品-代理映射 (from `_known_associations.md`):**
|
||
|
||
| 产品线 | 关联代理 / 中间方 | 关联客户 / 商机 |
|
||
|---|---|---|
|
||
| CelVivo (ClinoStar) | **济南成全生物科技 (曹沛起)** — 华北 + 山东 跨区重复 | 董慧群 (CelVivo 技术同事) — 8-07 hook 4 候选 |
|
||
| FemtoBiomed (CellShot / PROLIVA) | **9X Bio (汇佰生物)** — 中间方 (0 hit in 259 dealer 表) | TriArm Therapeutics (翁靖傑 上海 CGT/CAR-T, 128 万 Phase1 / 8-10 至 8-14 现场 demo) |
|
||
| 3Brain (HD-MEA) | 0 家代理命中 | 11+ end-customer dossiers (需要补 direct agent or sell direct) |
|
||
| Cellink (BIO X) | 0 家代理命中 | (待补) |
|
||
|
||
**Data gap (regional filling rate):** 华东 营收 0/68 / 湖北 营收 0/19 / 华南 销售人数 0/62 — needs补 before next field visit. Documented at [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) §关键数据缺口.
|
||
|
||
**4-vendor break-out is partially resolved:** the 2026-08-07 `_known_associations.md` index identifies CelVivo → 济南成全 + FemtoBiomed → 9X Bio; 3Brain / Cellink direct agents are still 0 (open-question `distributors-3brain-cellink-zero-coverage`).
|
||
|
||
## CRM — active distributor profiles
|
||
|
||
From [`/sources/agents.md`](/sources/agents.md) (last sync 2026-07-28; 2026-08-07 `_known_associations.md` partial resolution):
|
||
|
||
| 姓名 | 角色 | 代理商品牌 | 主推产品 | 首次记录 | 状态 | Vault 路径 |
|
||
| --- | --- | --- | --- | --- | --- | --- |
|
||
| 董慧群 | 代理商技术同事 | 待补 | CelVivo (ClinoStar / ClinoReactor) | 2026-07-28 | active | `02-Clients/Agents/董慧群.md` |
|
||
|
||
This is the only profile currently in the agents bucket. Robin was told about 董慧群 via WeChat DM on 2026-07-28; her role is to help push CelVivo products at the technical / demo / selection stage. Most fields are 待补 (agency name, region, phone, WeChat, customers, opportunities) — this is the only active open question in `/open-questions.md` (see `agent-dong-huiqun-celvivo`).
|
||
|
||
**2026-08-07 partial resolution (Hermes hook 4):** 4 个经销商管理 Hook 升级 (`02-Clients/Agents/_known_associations.md` commit `4b237a82`) identifies **济南成全生物科技有限公司 (曹沛起)** as the only CelVivo ClinoStar-listed agent in the 259-dealer China map (华北 + 山东 跨区重复登记). Whether 董慧群 is 济南成全的技术同事 or another dealer is still unverified — tracked as commitment `dong-huiqun-ji-nan-chengquan-link` in `/commitments.md`. The same hook 4 file maps FemtoBiomed CellShot → 9X Bio (汇佰生物) → TriArm Therapeutics (翁靖傑 上海 CGT/CAR-T, 128 万 Phase1 / 8-10 至 8-14 现场 demo), and 3Brain / Cellink / FemtoBiomed direct agents → 0 in the 259 baseline (open-question `distributors-3brain-cellink-zero-coverage`).
|
||
|
||
**Privacy rule (Robin 7-28):** `/sources/agents.md` and `/sources/distributors-china-2026.md` contain only base identity (name / role / vendor / region); sensitive fields (phone / WeChat / email / end-customer list / opportunity value) live only in the private Obsidian vault. The 2026-08-07 `_known_associations.md` index adds the **product-line → agent → end-customer → opportunity** mapping chain — but does not break the privacy rule because sensitive fields remain in the private vault files.
|
||
|
||
## End-customer dossier set
|
||
|
||
11+ dossiers under `03-Resources/End-Customers/` covering 3Brain HD-MEA accounts at: 神经所 (上海), 北京大学, 北京天坛医院, 浙大一附院, 中科院昆明动物所, 西南医科大学, 贵州医科大学, plus TCM accounts at 云南中医药大学 and 天津创新中药. Dossier content lives in the private vault — only the vault paths are surfaced to the wiki. Documented at [`/sources/git-repo.md`](/sources/git-repo.md) §Notable entities.
|
||
|
||
## CelVivo industrial-customers program (China commercial)
|
||
|
||
A dedicated subfolder under `05-Documents/Products/Celvivo/Industrial-Customers/` holds:
|
||
|
||
- `CelVivo_中国工业客户开发研究报告` (v1 + v2)
|
||
- `客户管线定位_1页图`
|
||
- `工业客户开发手册-v3`
|
||
|
||
This is a self-contained CelVivo China commercial effort. The latest mtime census (2026-07-16 snapshot) shows `CelVivo_中国工业客户开发研究报告_20260626_v2.md` as the most-recent file (18 KB, 06-26 11:52). Documented at [`/sources/git-repo.md`](/sources/git-repo.md) §Notable entities.
|
||
|
||
**2026-08-17 working-tree addition — `celvivo_commercial/1331651_20260630_131201.pdf`** (56 KB, 2026-06-30 quote PDF migrated into a new folder; **untracked**) — companion to the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree. The new folder name signals Robin may be consolidating "Celvivo commercial" documents into a separate vault subtree rather than continuing to nest them under `05-Documents/Products/Celvivo/Industrial-Customers/` (which is the prior convention). If the convention holds, future CelVivo commercial PDFs / quotes / pricing tables will land in `celvivo_commercial/` instead of `05-Documents/Products/Celvivo/Industrial-Customers/`; if it doesn't hold, it's a one-off folder for the 6-30 quote. Watchlist trigger: if a second PDF or commercial doc lands in `celvivo_commercial/` by the next git-repo fetch, the convention change is real; if it stays single-entry, it's a one-off.
|
||
|
||
## Work-rhythm snapshot (2026-07-16)
|
||
|
||
From [`/sources/vault-mtime-snapshot-2026-07-16.md`](/sources/vault-mtime-snapshot-2026-07-16.md) (last full mtime census):
|
||
|
||
```
|
||
2026-07-05 CelVivo 文献精读最后一次 (1 篇)
|
||
2026-06-26 销售培训物料最后一次更新 (v9 PPT + 逐字稿)
|
||
2026-06-18 memory/ 最后一次 daily report
|
||
2026-06-09 vault commit 最后一次
|
||
2026-06-06 CelVivo protocol 系列入库最后一次
|
||
2026-06-04 weekly report 最后一次
|
||
```
|
||
|
||
**Conclusion (snapshot date):** Past 3 weeks (post 2026-07-05) had 0 CelVivo activity. This is **real state**, not an OpenWiki gap. The snapshot recommends Robin write a `memory/2026-07-16-*.md` daily report to capture the gap. This also means the OpenWiki cron `vault-mtime-snapshot` connector is the canonical work-rhythm evidence — it complements the git-repo connector (commit history) and NocoDB (last-touched metadata).
|
||
|
||
## Cross-vendor route map
|
||
|
||
Each research output eventually lands in one of the vendor synthesis themes:
|
||
|
||
| Research artifact | Primary route | Secondary |
|
||
| --- | --- | --- |
|
||
| CelVivo deep reads + sales ammunition | [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) | CelVivo industrial-customers program → `/commitments.md` |
|
||
| 3Brain deep reads + end-customer dossiers | [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) | 3Brain conference positioning → `/commitments.md` `3brain-coreplate-2026-conference-positioning` |
|
||
| Cellink deep reads + BIO X customer evidence | [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md) | New Lumen X release → `/commitments.md` `cellink-volumetric-lumen-x-release` |
|
||
| Femtobiomed deep reads + CellShot-TriArm demo plans | (theme gap — Femtobiomed has no synthesis theme yet) | `01-Active-Sales/` plans → `/commitments.md` |
|
||
| Adjacent non-vendor (MSC / canine / PEMF / 综述) | `class-organoid-3d-bioprinting` theme row on [`/themes.md`](/themes.md) | — |
|
||
| China regulatory (CDE / Order 818 / CGT) | `/commitments.md` items `china-cde-cell-gene-therapy-rules-2026` / `china-order-no-818-clinical-translation` / `china-cgt-2026-july-developments` | — |
|
||
| Distributor / agent | [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) + [`/sources/agents.md`](/sources/agents.md) + `/open-questions.md` `agent-dong-huiqun-celvivo` | — |
|
||
|
||
## Personal-infra and adjacent work
|
||
|
||
These are source-anchored but not vendor-anchored — they live here for traceability but do **not** earn a `/themes.md` row:
|
||
|
||
- **ITX 24h host build (first observed 2026-07-31; still untracked)** — `03-Resources/ITX-24h-Host/ITX_24h_Host_v18_Config_2026-07-31.md`. Plan: mATX + i5-12400 + DDR4-2666 32G + 板载 Realtek 1Gb + Intel PRO/1000 GT 双网卡 NAS 隔离. Budget ¥2,985.82, 10/11 parts arrived. Status: paused awaiting last #8/#9 cable parts. Tracked as `/commitments.md` `itx-24h-host-build-2026-q3` (Owner: me).
|
||
- **OpenWiki cheat sheet (2026-07-27)** — `OpenWiki速查手册_2026-07-27.md` (vault root, untracked). Companion to [`/sources/OpenWiki速查手册.md`](/sources/OpenWiki速查手册.md) (the wiki copy).
|
||
- **4 vendor + 4 application + 4 agents SOP iterations** — the cluster of training materials under `06-Sales/Content/Training-Materials/` is iterated in place without commits; latest is `CelVivo_销售培训_PPT_v9` (06-26 14:13).
|
||
|
||
## Cross-cutting relationship
|
||
|
||
- **Touched by [`/themes/03-ai-agents.md`](/themes/03-ai-agents.md)** — M3 agent synthesis step (02:00 cron) writes research evidence into the synthesis themes; literature-deep-read SOP is what produces the canonical deep-read pages; sales-ammunition query skill routes ClinoReactor-related questions.
|
||
- **Touched by [`/themes/04-local-llm.md`](/themes/04-local-llm.md)** — RAGFlow KB (Celvivo / 3Brian / Cellink) is the deep retrieval surface behind every vendor deep read; SeaFile is the PDF + figure storage; NocoDB is the metadata catalog; Wiki.js is the public publishing target. The 2026-07-17 desktop service-down incident materially degrades the LDR pipeline.
|
||
- **Output routes into [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) and [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md)** — most of the deep reads and vendor evidence in this theme ends up at the vendor synthesis themes.
|
||
- **Outputs routed into `/commitments.md`** — China regulatory items + vendor-channel verification items + ITX host build + CellShot-TriArm demo plans.
|
||
- **Outputs routed into `/open-questions.md`** — `agent-dong-huiqun-celvivo` is the only currently active entry; it is anchored to `02-Clients/Agents/董慧群.md` and is the kind of "ambiguous people/org relationship" gap the wiki brief calls out.
|
||
|
||
## Backlog for this theme
|
||
|
||
- **Femtobiomed synthesis page** — `Femtobiomed CellShot / CellPick / TriArm` has a vault bucket and a `FemtoBiomed_electroporation` RAGFlow KB (123 docs) but no synthesis theme. Currently routes as adjacent cross-sell into `01` and `02`. Consider promoting to `themes/06-femtobiomed.md` if vendor-channel evidence accrues.
|
||
- **Hodge / Lee / Parate synthesis** — 3 adjacent deep reads added 2026-07-28 are not yet synthesized to `/sources/`. Run LDR Step 8 (NocoDB PATCH + Wiki.js publish + OpenWiki commit) when ready.
|
||
- **Work-rhythm snapshot connector** — currently a one-shot `find -mtime` shell command (see `/sources/vault-mtime-snapshot-2026-07-16.md` header). Promote to a weekly cron + auto-write to `/sources/vault-mtime-snapshot-weekly.md` so the work-rhythm signal is durable, not single-snapshot.
|
||
- **End-customer dossier cross-agent page** — 11+ dossiers live in private vault; consider adding a redacted `[name, focus, vendor, region, vault-path]` table to `/sources/agents.md` parallel to the distributor profile pattern. Robin decision pending.
|
||
- **CellShot-TriArm demo plan v3** — current demo plans are v1 (2026-07-21) and v2 (2026-07-22, 邮件用 + 老师版 two-commit split). No v3 yet; the v2 plan lives in vault commit history `1787702c` / `62877d1f` / `62d09c5f`. Promote to `/commitments.md` when v3 lands.
|
||
- **MOC pattern extension (2026-08-10 onward)** — Robin created the first MOC
|
||
(`04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md`, commit `6b717aef`,
|
||
95 lines, 沙牛《AI 时代的 Obsidian 公开课》课时 1 pattern); the MOC's
|
||
`related:` list already names the next planned MOC —
|
||
`[[MOC-3Brain-HD-MEA]]` — plus
|
||
`[[02-Clients/Agents/_known_associations]]` and
|
||
`[[02-Active-Deals/CellShot-TriArm-Demo-计划-v2-老师版-2026-07-20]]`.
|
||
Track on the next git-repo fetch whether the MOC pattern extends to
|
||
MOC-3Brain-HD-MEA, MOC-Cellink-BIO-X, MOC-Femtobiomed-CellShot, etc.
|
||
If ≥3 MOCs land, consider adding a `/themes.md` annex row on
|
||
`vault-knowledge-architecture` and a `/sources/` page that maps the
|
||
MOC graph (file → topics → cross-refs → flywheel cron hooks).
|
||
- **Phase A frontmatter batch rollout (2026-08-10 onward)** — Phase A
|
||
standardized 6 deep-read notes with the 6-field frontmatter
|
||
(doi / journal / year / volume / pages / authors / pmid); ~1,196
|
||
deep-read notes remain without the new fields. Track rollout
|
||
cadence — if Robin completes the batch on a fixed cadence (e.g.
|
||
daily/weekly cron), document the cadence here so future agents can
|
||
answer "what is the frontmatter hygiene status of the vault?".
|
||
|
||
## What to read next
|
||
|
||
| Question | Go to |
|
||
| --- | --- |
|
||
| What is the canonical LDR master template? | [`/sources/ldr-report-template.md`](/sources/ldr-report-template.md) |
|
||
| What did the 7-27 SOP-vs-implementation pass reveal? | [`/sources/2026-07-27-4-27-sop-vs-implementation.md`](/sources/2026-07-27-4-27-sop-vs-implementation.md) |
|
||
| What is the current Obsidian vault manifest? | [`/sources/git-repo.md`](/sources/git-repo.md) |
|
||
| What is the 30-day literature deep-read digest? | [`/sources/literature.md`](/sources/literature.md) |
|
||
| What is in the CelVivo sales ammunition kit? | [`/sources/sales-ammunition.md`](/sources/sales-ammunition.md) |
|
||
| What is the China 261-dealer map? | [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) |
|
||
| Who is Robin actively working with? | [`/sources/agents.md`](/sources/agents.md) |
|
||
| What is the work-rhythm cadence? | [`/sources/vault-mtime-snapshot-2026-07-16.md`](/sources/vault-mtime-snapshot-2026-07-16.md) |
|
||
| What does the CelVivo 2026 whitepaper say? | [`/sources/literature-celvivo-brain-whitepaper-2026.md`](/sources/literature-celvivo-brain-whitepaper-2026.md) |
|
||
| What does the Bosnjakovic 2025 PAH paper say? | [`/sources/literature-cel-bosnjakovic-2025-pah-deepread.md`](/sources/literature-cel-bosnjakovic-2025-pah-deepread.md) |
|
||
| What is the Raji 2026 hMOs + 3Brain story? | [`/sources/literature-raji-2026-deepread.md`](/sources/literature-raji-2026-deepread.md) |
|
||
| What is the Tasevska 2025 BIO X SSE story? | [`/sources/literature-tasevska-2025-deepread.md`](/sources/literature-tasevska-2025-deepread.md) |
|
||
| How does the agent stack consume this output? | [`/themes/03-ai-agents.md`](/themes/03-ai-agents.md) |
|
||
| How does the local-LLM fleet host this evidence? | [`/themes/04-local-llm.md`](/themes/04-local-llm.md) |
|
||
| Where does CelVivo + 3Brain output land? | [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) |
|
||
| Where does Cellink output land? | [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md) |
|
||
| What does Quintard 2024 say about vascularized organoid chips? | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
|
||
| What does Guo 2026 say about organoid IRB ethics? | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
|
||
| What's the IRB application checklist for organoid research? | `templates/类器官IRB申请清单.md` v1.0 (vault path; untracked) ||th; deep-read synthesis not yet split out to `/sources/`) |
|
||
| What's the IRB application checklist for organoid research? | `templates/类器官IRB申请清单.md` v1.0 (vault path; untracked) ||t path; untracked) || |