chore: daily update 2026-08-18
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{
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"updatedAt": "2026-08-16T18:05:13.757Z",
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"updatedAt": "2026-08-17T18:23:43.970Z",
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"command": "update",
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"model": "MiniMax-M3",
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"status": "interrupted",
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"status": "complete",
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"language": "en"
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}
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type: "Reference"
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title: "Commitments"
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description: "Active work tasks, follow-ups, approvals, and scheduled items extracted from sources (web-search, git-repo, literature flywheel-sync, etc.). Personal errands live in /personal-logistics.md instead."
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tags: [commitments, work, follow-ups, distributors-2026-08-07-refresh, dong-huiqun-ji-nan-chengquan-link, liang-2026-celvivo-clinostar-positioning]
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tags: [commitments, work, follow-ups, distributors-2026-08-07-refresh, dong-huiqun-ji-nan-chengquan-link, liang-2026-celvivo-clinostar-positioning, guo-2026-organoid-irb-checklist-rollout]
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---
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# Commitments
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@@ -116,6 +116,13 @@ Concrete work tasks, follow-ups, approvals, and scheduled items extracted from G
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- Status: open
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- Notes: 8-07 baseline differs from 7-24 baseline in: (a) total 261 → 259 (华北 74 → 72); (b) 济南成全生物科技有限公司 (曹沛起) cross-region registration (华北 + 山东); (c) new `_known_associations.md` index maps CelVivo → 济南成全 / FemtoBiomed → 9X Bio → TriArm / 3Brain + Cellink → 0. Cross-reference: [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) has been updated to the 8-07 baseline + new associations table; [`/sources/agents.md`](/sources/agents.md) still needs the 董慧群 → 济南成全 link; [`/commitments.md`](/commitments.md) has follow-up for 成都百乐 vs 成都立德赛 decision (open-question `chengdu-baile-vs-lidesai-for-ou-xianhong`). End-customer coverage for 3Brain / Cellink / FemtoBiomed still 0 in the 259 baseline — see open-question `distributors-3brain-cellink-zero-coverage`.
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### guo-2026-organoid-irb-checklist-rollout: commit IRB application checklist template + add Guo 2026 deep-read synthesis page + fold into CelVivo industrial-customers program
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- Owner: me
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- Source: git-repo-1 2026-08-17 — vault commit cluster `2e6f5989` → `00f824f2` → `a4fa5a32` (Guo Z & Zhang N 2026 Front Cell Dev Biol organoid IRB / ethics systematic review, Wiki.js ID 1724, NocoDB Id 3298, DOI 10.3389/fcell.2026.1721946) + new untracked `templates/类器官IRB申请清单.md` v1.0 (180 lines, Robin 8-16 实战沉淀, derived from the Guo 2026 paper)
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- Due: unscheduled
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- Status: open
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- Notes: **First customer-facing template produced from a single deep-read** in Robin's vault — the IRB application checklist is the canonical "Robin 培训客户 IRB 申请" core material for class A tertiary hospitals running organoid IRB submissions. The 7 mandatory points + 5 customer Q&A + China vs International flow table + 10 attachments + 7 citations map directly to the CelVivo ClinoStar clinical-translation sales narrative (Guo 2026 lists CelVivo ClinoStar ⭐⭐⭐⭐ for IRB compliance ammunition). **Three follow-ups needed**: (a) **commit** `templates/类器官IRB申请清单.md` to `main` (currently untracked); (b) add a wiki-side deep-read synthesis page at `/sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md` mirroring the pattern at `/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`; (c) fold the IRB checklist into the existing `05-Documents/Products/Celvivo/Industrial-Customers/` CelVivo commercial docs subtree (or, if the `templates/` folder convention holds, fold it into the new `templates/` vault subtree instead — see Robin decision). Companion commitment to fold into Chinese customer IRB conversations: the checklist covers China《人类遗传资源管理条例》+ 《涉及人的生命科学和医学研究伦理审查办法》2023 — directly applicable to the next Class A tertiary hospital Robin visits for CelVivo or 3Brain training.
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<!--
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Structure for new entries:
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@@ -14,5 +14,6 @@ okf_version: "0.1"
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# Directories
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- [large_tool_results](large_tool_results/)
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- [sources](sources/)
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- [themes](themes/)
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## Current status
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- **Wiki state:** initialized — Hacker News, the local Obsidian vault, and Tavily web search are active and feeding `/sources/hackernews.md`, `/sources/git-repo.md`, `/sources/web-search.md`, and `/themes.md`. All 5 synthesis themes (`/themes/01-organoid-equipment.md`, `/themes/02-bioprinting.md`, `/themes/03-ai-agents.md`, `/themes/04-local-llm.md`, `/themes/05-robin-research.md`) are now generated.
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- **Connectors:** Hacker News, git-repo, and web search active. The 2026-08-08, 2026-08-10, 2026-08-12, and 2026-08-15 web-search update attempts were skipped because the connector is not enabled and `TAVILY_API_KEY` is empty; the latest successful Tavily pull remains 2026-08-03 18:08 UTC. Gmail, Slack, Notion, and X are not yet configured — see "Adding sources" below.
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- **Wiki state:** initialized — Hacker News, the local Obsidian vault, and Tavily web search are active and feeding `/sources/hackernews.md`, `/sources/git-repo.md`, `/sources/web-search.md`, and `/themes.md`. All 5 synthesis themes (`/themes/01-organoid-equipment.md`, `/themes/02-bioprinting.md`, `/themes/03-ai-agents.md`, `/themes/04-local-llm.md`, `/themes/05-robin-research.md`) are now generated; the 2026-08-17 daily update also created `/sources/openwiki-version-drift.md` (auto-generated OpenWiki version-drift monitor).
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- **Connectors:** Hacker News, git-repo, and web search active. The 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, and 2026-08-17 web-search update attempts were skipped because the connector is not enabled and `TAVILY_API_KEY` is empty; the latest successful Tavily pull remains 2026-08-03 18:08 UTC. Gmail, Slack, Notion, and X are not yet configured — see "Adding sources" below.
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**Latest update — git-repo-1 (2026-08-17T18:09Z).** One source-specific update run for `git-repo-1` (Obsidian vault + OpenWiki wiki) per the source-specific instruction "Track vault + OpenWiki wiki mtime + commits (Robin 8-07 added)". Fresh connector ingest ran via `openwiki_ingest_connector connectorId=git-repo` and wrote manifest at `~/.openwiki/connectors/git-repo/raw/2026-08-17T18-09-32-895Z/manifest.json`. **Vault HEAD** bumped from `297f106d2b137af3480261052ff080cbc48d5b48` (2026-08-15) to **`a4fa5a323d6dcabeb9eccad49e636ee6ba5f87a6`** (2026-08-16); **7 new vault commits** landed in the 2026-08-15T18:07Z → 2026-08-17T18:09Z 48-hour window, forming **two new paper LDR cycles in the same window** — **the first time since the 2026-07-28 / 2026-07-29 Parate / Lee / Hodge cluster that two new paper deep-reads landed on `main` in the same 48-hour window**: (a) **Quintard 2024 Nat Commun** (DOI 10.1038/s41467-024-45710-4, Wiki.js IDs 1719/1720/1722, NocoDB Id 3297) — microfluidic platform integrating functional vascularized organoids-on-chip — **4-commit LDR cycle** (`0fc8db24` adds file 189 lines → `290e9635` -v2 修图床/双 H1/落款 → `24c713de` -v3 Wiki.js 自带图床 6 张图 → `4073abf4` -v4 转发语标题/落款加粗/删 3Brain per the SOP "硬门槛合规修正" cleanup rule); 10 通道并行微流控芯片 + U 型捕获位 + hiPSC-BVO 30 天功能性灌注培养 + 跨类器官验证 [间充质球体 / BVO / 胰岛球体 / 肺类器官]; "与我们的产品" table lists Mimetas OrganoPlate ⭐⭐⭐⭐ [direct Phaseguide-based vascularized / kidney / intestine organ-on-chip competitor] + CelVivo ClinoStar ⭐⭐⭐ [upstream workflow: BVO day 0-15 needs rotating-wall suspension culture, ClinoStar is the canonical hardware for this stage; the paper's day 15 → chip-on-board handoff is the canonical CelVivo → organ-on-chip workflow] + Emulate Organ-Chip ⭐⭐⭐; (b) **Guo 2026 Front Cell Dev Biol** (DOI 10.3389/fcell.2026.1721946, Wiki.js ID 1724, NocoDB Id 3298) — organoid IRB / ethics systematic review — **3-commit LDR cycle** (`2e6f5989` adds file 170 lines → `00f824f2` -v2 修图床 (加 2 张 Wiki.js 自带图) → `a4fa5a32` -v3 补 Fig 1); 嘉兴市第一医院 + 嘉兴大学医学院视角; 类器官研究 IRB / 伦理审查 7 大强制要点系统综述 [样本来源/知情同意/数据隐私/共培养主体性/3R 动物福利/跨境监管/长期保存与终止使用] + 中国《人类遗传资源管理条例》+ 国际 ISSCR/GDPR/HIPAA 多国对照表; "与我们的产品" table lists CelVivo ClinoStar ⭐⭐⭐⭐ [临床转化类器官的伦理合规 — 7 大要点直接适用 ClinoStar 客户 IRB 申请; **Robin 推广 ClinoStar 给三甲医院时, 可附带本框架作为增值**] + Mimetas OrganoPlate ⭐⭐⭐⭐ [类器官 + 免疫细胞共培养伦理审查依据] + Emulate Organ-Chip ⭐⭐⭐. **The Quintard + Guo cluster brings net-new external evidence** to the vault — both papers are added to the `Organoid/` subfolder (count 659 → 661) + 30-day research output + the by-vendor table on `/themes/05-robin-research.md`. **2 new untracked directories** appeared in the working tree this fetch: (i) **`celvivo_commercial/1331651_20260630_131201.pdf`** (the 6-30 quote PDF migrated into a new folder, companion to the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree — the new folder name signals Robin may be consolidating "Celvivo commercial" documents into a separate vault subtree); (ii) **`templates/类器官IRB申请清单.md`** (180 lines, **untracked**, Robin 8-16 实战沉淀, derived from the Guo 2026 ethics deep-read — **first customer-facing template produced from a single deep-read** — 7 mandatory points checklist + 5 customer Q&A + China vs International flow table + 10 attachments + 7 citations; Robin's canonical "Robin 培训客户 IRB 申请" core material). The carry-forward untracked file `Review/zhou2023_computer_vision_microfluidics.md` from the 2026-08-13 fetch remains untracked at the 2026-08-17 fetch (now joined by 2 new untracked working-tree directories). **Wiki HEAD** bumped from `2507925e27b83b4f9d2e6f3b9c939d081a90f9f2` (2026-08-15) to **`be4928553364a654b888807a44438b738072c2ce`** (2026-08-17); **4 new wiki-side commits** in the same 48-hour window: `151d22b` chore: daily update 2026-08-16 (committed `sources/index.md` from the 2026-08-15 dirty set) + `997b648` sources-sync 2026-08-16 + `5c70881` chore: daily update 2026-08-17 (**created new file `sources/openwiki-version-drift.md`** — auto-generated OpenWiki version-drift monitor; reports v0.3.1 local → v0.3.3 npm latest as of 2026-08-15T20:00:03Z) + `be49285` sources-sync 2026-08-17. **9 uncommitted wiki files** in working tree (down from 10 at the 2026-08-15 fetch — `sources/index.md` got committed in `151d22b`); the 9 dirty files are `.last-update.json` + `quickstart.md` + `sources/README.md` + `sources/hackernews.md` + `soLine truncated
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**Latest update — web-search-1 attempted 2026-08-17 skipped.** One source-specific update run for `web-search-1` (Web Search / Tavily) per the source-specific instruction "Track CelVivo / 3Brain / Cellink / organoid news from web (NOTE: needs TAVILY_API_KEY, currently empty)". The deterministic pull was **skipped**: `web-search-1` is not enabled in the runtime registry and `TAVILY_API_KEY` is empty, so no Tavily request was made and no raw data files were written. The nightly searxng-fallback slot `~/.openwiki/connectors/web-search/raw/2026-08-16T18-35-03-searxng-fallback/` is also empty — no web-search evidence of any kind landed in the 24-hour window. This is the **fifth consecutive skip** on the same code path (after 2026-08-08 + 2026-08-10 + 2026-08-12 + 2026-08-15); the latest successful Tavily pull remains 2026-08-03 18:08 UTC. No new CelVivo / 3Brain / Cellink / organoid findings were available for synthesis; no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt. Discord between on-disk `~/.openwiki/connectors/web-search/config.json` (which shows `enabled: true` + 6 Chinese queries) and the runtime registry (still reports the connector as disabled) is the same operational issue noted on the 2026-08-08 / 2026-08-10 / 2026-08-12 / 2026-08-15 runs — recorded for traceability only, not a wiki-synthesis concern. Wiki edits this run: (a) `/sources/web-search.md` — added a "2026-08-17 attempted update — skipped" section ahead of the 2026-08-15 entry, following the established 5-field structure (Status / Authentication / Coverage / Synthesis / Operational note); updated the header line to mention the fifth skip; refreshed the 2026-08-15 entry's "Operational note" to mention the 2026-08-17 follow-up; added `2026-08-17` to the `tags` list; (b) `/sources/README.md` — refreshed Active connectors table + Connector roll table to reflect the 5-entry skip streak; (c) `/quickstart.md` — added this "Latest update — web-search-1 attempted 2026-08-17 skipped" paragraph; updated the Web Search connector row in "Current status" and "Adding sources" to reflect the 5-entry skip streak; updated the Backlog web-search entry likewise. **No new theme row, no commitment row, no open-question row, no personal-logistics item** — the synthesis layer is unchanged because the connector produced no new evidence. Prior run was **hackernews-1 update (2026-08-17T18:00Z)** — see next paragraph.
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**Latest update — hackernews-1 (2026-08-17T18:00Z).** One source-specific update run for `hackernews-1` (Hacker News — LLM-agent topic set) per the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories". Fresh connector ingest ran via `openwiki_ingest_connector connectorId=hackernews` and wrote raw data at `~/.openwiki/connectors/hackernews/raw/2026-08-17T18-00-01-808Z/hackernews-results.json`. 2 feeds (`top` 26 + `best` 17) → **34 unique items** (9 overlap: `49324985` Qwen 3.8 27B, `49324087` Anthropic Claude watermarks, `49330781` DuckDB v2.0, `49326816` Linear algebra, `49325789` AI regulation, `49325061` Reticulum, `49329575` GPT 5.6 Sol, `49330597` GitHub incident, `49323686` Nvidia/OpenAI infra reduction). 6 search queries (`organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents`) returned **zero vendor-anchored hits** — `organoid` (6 nbHits, all string-collision noise on the "organi-" substring), `CelVivo` (0), `3Brain` (6 nbHits, all string-collision noise on the "brain" substring), `Cellink` (6 nbHits, all string-collision noise on "calling"/"ceiling"/"celine"/"welling" substrings), `openwiki` (0), `deepagents` (0). The "no material HN footprint for the 4 vendor lines" finding continues to hold — this is the **sixth pull since 2026-08-07 to have an empty / noise-only Algolia lane on vendor queries** (after the 2026-08-08 03:15 + 2026-08-08 18:00 + 2026-08-13 + 2026-08-15 + 2026-08-16 fully-zero pulls; the 2026-08-10 + 2026-08-12 pulls were also noise-only on the substring queries); Tavily (web-search) remains the productive lane for vendor news. **Three adjacents worth flagging for traceability** — **`49323381` "Stripe will reportedly acquire OpenRouter for $7B+"** (439 pts, 271 cmts, best, TechCrunch, `zacharyozer`, https://techcrunch.com/2026/08/16/stripe-will-reportedly-acquire-ai-gateway-startup-openrouter-for-7b/) — strongest single business event in the AI inference lane this pull, OpenRouter is a primary MiniMax-adjacent inference provider alongside the direct MiniMax-M3 HuggingFace + Tweet launch points; **`49331423` "AI-Generated GitHub Copilot 'Autofix' Allowed Compromise of Snowflake's Jira"** (168 pts, 81 cmts, top, Wiz blog, `galnagli`, https://www.wiz.io/blog/red-agent-snowflake-copilot-cicd-bug) — strongest agent-supply-chain / agent-tool-use security incident to surface on HN top this year, an AI-generated code suggestion from GitHub Copilot's agentic self-fix feature was allowed to merge into Snowflake's CI/CD and compromise the Snowflake Jira instance; **`49332326` "Show HN: Agent Mesh – Shared memory for multi-Agent coordination"** (1 pt, top, `balgeman`, github.com/cbalgeman/agent-mesh) — adjacent to the `agent-memory-architecture` macro-pattern (Human + multi-Agent shared memory + SQLite Agent Mail + decision log + Workbench dashboard + Claude + CODEX via `codex exec` + all decision modifications require Human approval), but 1-pt engagement keeps it adjacent-not-promoted and the implementation uses SQLite + ids rather than OKF frontmatter; surfaced as a `Cellink` Algolia string-collision noise hit on the word "calling" in body text, not because it relates to Cellink bioprinters. Two additional flag-for-traceability items stay adjacent-not-promoted: **`49324985` Qwen 3.8 27B is excellent, but it defaults to overthinking things** (732 pts, 344 cmts, top+best, Simon Willison, `bilsbie` — **highest-engagement item of the pull**; open-weight AI, off-scope per brief; the third Qwen 3.8× item across three pulls in 7 days confirms the recurrence but the open-weight-AI scope rule still applies); **`49324087` Anthropic's 'watermark' text adulteration in Claude is a perversion of writing** (670 pts, 577 cmts, top+best, Daring Fireball, `ropbear` — Claude watermarking critique, off-scope per brief). **Key call**: this pull produces **no directly-relevant item for any `/themes.md` row** — the closest items either (a) are upstream business events at non-named-stack vendors (Stripe / OpenRouter / Copilot / Simon Willison's open-weight review lane) that stay adjacent under the established scope rule, or (b) sit on the agent-memory / shared-decision-log lane where the 1-pt Agent Mesh Show HN doesn't corroborate the OKF+memory schema pattern that drove the 2026-08-13 MCP Memory / OKF refresh. The `class-organoid-3d-bioprinting` row stays at Last seen 2026-08-12 (no organoid item — the 6 organoid Algolia hits are all string-collision noise); the `agent-memory-architecture` row stays at Last seen 2026-08-13 (Agent Mesh at 1 pt is below the established refresh threshold + uses SQLite rather than OKF); the `MiniMax-m3` row stays at Last seen 2026-08-03 (no MiniMax model release; `49323381` Stripe-OpenRouter is an upstream business event, not a MiniMax change); the `hermes-agent-v0-19-quicksilver` row stays at Last seen 2026-08-03 (no Hermes Agent release; `49331423` Copilot Autofix is a GitHub Copilot incidentLine truncated
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**Latest update — hackernews-1 (2026-08-16T18:00Z).** One source-specific update run for `hackernews-1` (Hacker News — LLM-agent topic set) per the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories". Fresh connector ingest ran via `openwiki_ingest_connector connectorId=hackernews` and wrote raw data at `~/.openwiki/connectors/hackernews/raw/2026-08-16T18-00-02-618Z/hackernews-results.json`. 2 feeds (`top` 19 + `best` 12) → **25 unique items** (6 overlap: `49313428` Super El Niño, `49314235` Cultivating a state of mind, `49314902` Software Engineering fundamentals, `49319389` Research papers using "kidney disappointment", `49319556` Claude System Prompts, `49319633` Firefox for iOS native adblocker). 6 search queries (`organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents`) returned **zero hits across all six** — all six Algolia queries returned `nbHits=0`. The "no material HN footprint for the 4 vendor lines" finding continues to hold — this is the **fifth pull since 2026-08-07 to have a fully-zero Algolia lane** (after the 2026-08-08 03:15 + 2026-08-08 18:00 + 2026-08-13 + 2026-08-15 pulls; the 2026-08-10 + 2026-08-12 pulls had Algolia hits that were all string-collision noise rather than fully-zero); Tavily (web-search) remains the productive lane for vendor news. **Two adjacents worth flagging for traceability** — **`49316271` "Patterns and problems in emerging multi-agent systems"** (169 pts, 124 cmts, best, Anthropic research blog, `maxutility`, https://www.anthropic.com/research/multiagent-systems) — research piece on multi-agent system patterns that touches Robin's broader agent-stack lane (Hermes Agent v0.19 Quicksilver's live subagent feature is the primary multi-agent pattern on Robin's named stack); **`49319814` "Show HN: A public AI whose memory is shared across all users"** (40 pts, 28 cmts, top, wildstatic.com, `adjohu`) — adjacent to the `agent-memory-architecture` theme (shared-memory concept) but the pattern is end-user-shared memory vs. the OKF/Karpathy/MCP-Memory agent-side memory architecture. Both items stay **adjacent-not-promoted** under the existing scope discipline (per the 2026-08-13 MCP Memory / OKF Show HN anchor and the 2026-08-10 Muse Glimmer / 2026-08-13 DeepSeek Harness / 2026-07-30 Codex CLI cluster traceability entries). Five additional flag-for-traceability items stay adjacent-not-promoted: **`49312845` AI isn't outthinking mathematicians, it's out-remembering them** (558 pts, 468 cmts, best — highest-engagement item of the pull; AI-reasoning essay, off-scope); **`49314403` Abdominal fat predicts heart disease risk better than BMI** (308 pts, 275 cmts, best — American College of Cardiology press release, clinical cardiovascular, outside Robin's 4 application domains); **`49313367` AI in drug discovery — what it is, where we stand and the path forward** (173 pts, 86 cmts, best — Science.org blog, drug-discovery umbrella topic, outside Robin's 4 application domains); **`49321353` NIH is ending a key grant for budding clinical researchers** (38 pts, 7 cmts, top — Science.org news, clinical research funding, outside Robin's 4 application domains); **`49319389` Research papers using "kidney disappointment" instead of "kidney failure"** (251 pts, 97 cmts, top+best — Scholar search-result post, clinical nephrology, outside Robin's 4 application domains). **Key call**: this pull produces **no directly-relevant item for any `/themes.md` row** — the closest items either (a) fall outside Robin's 4 application domains (clinical cardiovascular / drug discovery / clinical research funding / nephrology) and stay off the `class-organoid-3d-bioprinting` watchlist per the "domain-anchored only" scope rule, or (b) sit on the AI-agent / multi-agent / shared-memory lane where the established scope rule keeps non-named-stack agent-architecture research adjacent-not-promoted unless there is a direct change to Hermes / MiniMax / OpenWiki / Codex CLI itself. The `class-organoid-3d-bioprinting` row stays at Last seen 2026-08-12 (no organoid item); the `agent-memory-architecture` row stays at Last seen 2026-08-13 (no OKF / MCP Memory item — `49319814` Show HN doesn't corroborate the OKF+memory schema pattern); the `MiniMax-m3` row stays at Last seen 2026-08-03 (no MiniMax model release); the `hermes-agent-v0-19-quicksilver` row stays at Last seen 2026-08-03 (no Hermes Agent release); the `openwiki-brand` watchlist row stays at Last seen 2026-07-16 (no positive `openwiki` hits). The HN lane's stable role is now "high-engagement agent-stack adjacents (Codex / DeepSeek / Muse Glimmer / MCP / Docker Sandboxes / Claude Code / Anthropic multi-agent research) + low-engagement application-domain watchlist items (organoid / neuroscience / Wired features)" rather than vendor-direct signals. Wiki edits this run: (a) `/sources/hackernews.md` — added new "Latest update — 2026-08-16 18:00 UTC" section ahead of Line truncated
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@@ -66,7 +72,7 @@ When Robin is ready, configure connectors to start populating the wiki:
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- **Slack** — `openwiki auth slack` (needs Slack user token with `search:read` for definitive self-message search)
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- **Notion** — configure Notion MCP via `~/.openwiki/connectors/notion/`
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- **X / Twitter** — `openwiki auth x` (needs `OPENWIKI_X_ACCESS_TOKEN`)
|
||||
- **Web Search** — set `TAVILY_API_KEY` (active; latest successful pull 2026-08-03 18:08 UTC; the 2026-08-08, 2026-08-10, and 2026-08-12 update attempts were skipped because the connector is not enabled in the runtime registry — see [/sources/web-search.md](/sources/web-search.md))
|
||||
- **Web Search** — set `TAVILY_API_KEY` (active; latest successful pull 2026-08-03 18:08 UTC; the 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, and 2026-08-17 update attempts were skipped because the connector is not enabled in the runtime registry — see [/sources/web-search.md](/sources/web-search.md))
|
||||
- **Hacker News** — public feeds, no auth needed
|
||||
- **Local git repo** — point the `git-repo` connector at a repo path
|
||||
|
||||
@@ -80,9 +86,9 @@ Deferred until Robin configures connectors or asks for specific documentation:
|
||||
- **Slack evidence index** — `/sources/slack.md` (no Slack connector configured yet)
|
||||
- **Notion evidence index** — `/sources/notion.md` (no Notion MCP configured yet)
|
||||
- **X / Twitter evidence index** — `/sources/x.md` (no X connector configured yet)
|
||||
- **Hacker News evidence index** — `/sources/hackernews.md` (active; last refreshed 2026-08-16 18:00 UTC — source-specific LLM-agent topic set (`organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents`); **fifth pull since 2026-08-07 to have a fully-zero Algolia lane** (after 2026-08-08 03:15 + 2026-08-08 18:00 + 2026-08-13 + 2026-08-15 — the 2026-08-10 and 2026-08-12 pulls had Algolia hits that were all string-collision noise rather than fully-zero) — vendor-anchored footprint remains null on the HN lane and Tavily (web-search) remains the productive lane; **two adjacents worth flagging for traceability surfaced this pull: `49316271` "Patterns and problems in emerging multi-agent systems"** (169 pts, 124 cmts, best, Anthropic research blog, `maxutility`, https://www.anthropic.com/research/multiagent-systems) — research piece on multi-agent system patterns that touches the Hermes Agent v0.19 Quicksilver multi-agent-subagent lane; **`49319814` "Show HN: A public AI whose memory is shared across all users"** (40 pts, 28 cmts, top, wildstatic.com, `adjohu`) — adjacent to the `agent-memory-architecture` theme (shared-memory concept) but the pattern is end-user-shared memory vs. the OKF/Karpathy/MCP-Memory agent-side memory architecture. **Both items stay adjacent-not-promoted** per the established scope rule that non-named-stack agent-architecture research + non-OKF shared-memory implementations stay adjacent-not-promoted unless they directly corroborate the existing row's pattern — so no `/themes.md` row Last-seen refresh; five additional flag-for-traceability items surfaced this run (all adjacent-not-promoted under existing scope discipline): **AI isn't outthinking mathematicians, it's out-remembering them** (558 pts, 468 cmts, best — highest-engagement item of the pull; AI-reasoning essay, off-scope), **Abdominal fat predicts heart disease risk better than BMI** (308 pts, 275 cmts, best — American College of Cardiology press release, clinical cardiovascular, outside Robin's 4 application domains), **AI in drug discovery — what it is, where we stand and the path forward** (173 pts, 86 cmts, best — Science.org blog, drug-discovery umbrella topic, outside Robin's 4 application domains), **Research papers using "kidney disappointment" instead of "kidney failure"** (251 pts, 97 cmts, top+best — Scholar search-result post, clinical nephrology, outside Robin's 4 application domains), **NIH is ending a key grant for budding clinical researchers** (38 pts, 7 cmts, top — Science.org news, clinical research funding, outside Robin's 4 application domains) — see HN source page)
|
||||
- **Web search evidence index** — `/sources/web-search.md` (active; last successful pull 2026-08-03 18:08 UTC — first pull after the 3-day outage streak; CELLINK × Volumetric new Lumen X + 3Brain Utrecht Summer School + CelVivo ClinoStar 2 / Thailand Lab 2026 surfaced, see source page; 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, and 2026-08-16 update attempts skipped — connector not enabled in runtime registry, `TAVILY_API_KEY` missing; disk config shows `enabled: true` + 6 Chinese queries but the runtime registry disagrees — operational concern, not a wiki-synthesis concern)
|
||||
- **Git repo evidence index** — `/sources/git-repo.md` (active; last refreshed 2026-08-15 18:07 UTC — covers Robin's Obsidian vault (HEAD `297f106d` 2026-08-12, **unchanged across both the 2026-08-13 and 2026-08-15 fetches** — 0 new vault commits in the 2026-08-13T18:08Z → 2026-08-15T18:07Z 48-hour window) + OpenWiki wiki (HEAD `2507925` 2026-08-15, **4 new wiki commits since 2026-08-13**: `021e929` daily update 2026-08-14 + `6258717` sources-sync 2026-08-14 + `173b58c` daily update 2026-08-15 + `2507925` sources-sync 2026-08-15); 13 vault commits since 2026-08-03 fetch including the **2026-08-12 Liang 2026 Sci Rep liver organoid fibrosis platform 4-commit LDR cycle** (`e542c977` adds file 186 lines → `8699a154` page 946 9 项 SOP 重写版 105+/122- → `aacba7aa` frontmatter title 改中文 1 line → `297f106d` page 934 修齐 5+/4-) — **net-new external evidence** (DOI 10.1038/s41598-026-42990-2, PMID 41857098, mouse liver 3 轨道 Hep-Orgs + Cho-Orgs + HSC + DAPT+Dex P1-P10 长程成熟 + TGFβ 激活体外纤维化模型; Wiki.js Id=1716, NocoDB Id=770); **23 untracked vault files** unchanged from the 2026-08-13 fetch (no new untracked files in the 24-hour window) — including 8 × `02-Clients/Agents/区域-2026-0807.md` distributors-rebuild + `_known_associations.md` association index + **the first entry in the new `Review/` subfolder** (`04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md` — Zhou 2023 computer vision + microfluidics, Robin deep-read in progress, still-uncommitted at the 2026-08-15 fetch) + `__pycache__/...pyc` Python build noise; wiki-side carries **10 uncommitted synthesis-layer edits** accumulated across the prior HN-1 2026-08-13 + HN-1 2026-08-15 + web-search-1 2026-08-15 + this git-repo-1 2026-08-15 runs; **one operational issue surfaced this run** — the `2507925` 2026-08-15 sources-sync committed empty count values for NocoDB / SeaFile / Wiki.js / RAGFlow (NocoDB 6614 → 0 records, Wiki.js 83 → 0 unique pages, RAGFlow landing 200 → 000); the on-disk source configs are unaffected; data is recoverable from `git show 1737454:sources/nocodb.md` etc. — recorded for traceability on `/sources/git-repo.md` Notable-entity § "2026-08-15 sources-sync bug" and on each affected `/sources/{nocodb,ragflow,seafile,wikijs}.md` page; the synthesis layer (themes / commitments / open-questions / personal-logistics) is independent of the source-page counters and is not affected)
|
||||
- **Hacker News evidence index** — `/sources/hackernews.md` (active; last refreshed 2026-08-17 18:00 UTC — source-specific LLM-agent topic set (`organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents`); **sixth pull since 2026-08-07 to have an empty / noise-only Algolia lane on vendor queries** (after the 2026-08-08 03:15 + 2026-08-08 18:00 + 2026-08-13 + 2026-08-15 + 2026-08-16 fully-zero pulls; the 2026-08-10 + 2026-08-12 pulls were also noise-only on the substring queries) — vendor-anchored footprint remains null on the HN lane and Tavily (web-search) remains the productive lane; **three adjacents worth flagging for traceability surfaced this pull: `49323381` "Stripe will reportedly acquire OpenRouter for $7B+"** (439 pts, 271 cmts, best, TechCrunch, `zacharyozer`, https://techcrunch.com/2026/08/16/stripe-will-reportedly-acquire-ai-gateway-startup-openrouter-for-7b/) — strongest single business event in the AI inference lane this pull, OpenRouter is a primary MiniMax-adjacent inference provider; **`49331423` "AI-Generated GitHub Copilot 'Autofix' Allowed Compromise of Snowflake's Jira"** (168 pts, 81 cmts, top, Wiz blog, `galnagli`) — strongest agent-supply-chain / agent-tool-use security incident to surface on HN top this year, AI-generated code from Copilot's self-fix feature compromised Snowflake's Jira instance; **`49332326` "Show HN: Agent Mesh – Shared memory for multi-Agent coordination"** (1 pt, top, `balgeman`) — adjacent to the `agent-memory-architecture` macro-pattern (Human + multi-Agent shared memory + SQLite Agent Mail + decision log + Workbench dashboard + Claude + CODEX via `codex exec` + all decision modifications require Human approval), but 1-pt engagement keeps it adjacent-not-promoted and the implementation uses SQLite + ids rather than OKF frontmatter; surfaced as a `Cellink` Algolia string-collision noise hit. **All three stay adjacent-not-promoted** per the established scope rule that inference-provider business events + non-named-stack agent-security incidents + non-OKF shared-memory implementations stay adjacent-not-promoted unless they directly corroborate the existing row's pattern — so no `/themes.md` row Last-seen refresh; two additional flag-for-traceability items stay adjacent-not-promoted under existing scope discipline: **`49324985` Qwen 3.8 27B is excellent, but it defaults to overthinking things** (732 pts, 344 cmts, top+best, Simon Willison, `bilsbie` — **highest-engagement item of the pull**; open-weight AI, off-scope per brief); **`49324087` Anthropic's 'watermark' text adulteration in Claude is a perversion of writing** (670 pts, 577 cmts, top+best, Daring Fireball, `ropbear` — Claude watermarking critique, off-scope per brief) — see HN source page)
|
||||
- **Web search evidence index** — `/sources/web-search.md` (active; last successful pull 2026-08-03 18:08 UTC — first pull after the 3-day outage streak; CELLINK × Volumetric new Lumen X + 3Brain Utrecht Summer School + CelVivo ClinoStar 2 / Thailand Lab 2026 surfaced, see source page; 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, and 2026-08-17 update attempts skipped — connector not enabled in runtime registry, `TAVILY_API_KEY` missing; disk config shows `enabled: true` + 6 Chinese queries but the runtime registry disagrees — operational concern, not a wiki-synthesis concern)
|
||||
- **Git repo evidence index** — `/sources/git-repo.md` (active; last refreshed 2026-08-17 18:09 UTC — covers Robin's Obsidian vault (HEAD `a4fa5a32` 2026-08-16, **7 new vault commits since the 2026-08-15 fetch**: the 2026-08-16 **Quintard 2024 Nat Commun microfluidic vascularized organoid chip 4-commit LDR cycle** `0fc8db24` → `290e9635` → `24c713de` → `4073abf4` [Wiki IDs 1719/1720/1722, NocoDB Id 3297] + the 2026-08-16 **Guo 2026 Front Cell Dev Biol organoid ethics systematic review 3-commit LDR cycle** `2e6f5989` → `00f824f2` → `a4fa5a32` [Wiki ID 1724, NocoDB Id 3298] — **first time two new paper deep-reads landed on `main` in the same 48-hour window since the 2026-07-28 / 2026-07-29 Parate / Lee / Hodge cluster**) + OpenWiki wiki (HEAD `be49285` 2026-08-17, **4 new wiki commits since the 2026-08-15 fetch**: `151d22b` daily update 2026-08-16 + `997b648` sources-sync 2026-08-16 + `5c70881` daily update 2026-08-17 + `be49285` sources-sync 2026-08-17) + **1 new wiki file**: `sources/openwiki-version-drift.md` (auto-generated OpenWiki version-drift monitor; v0.3.1 local → v0.3.3 npm latest as of 2026-08-15T20:00:03Z); **20 vault commits since 2026-08-03 fetch** (was 13 at the 2026-08-15 fetch; the +7 delta is the Quintard 2024 + Guo 2026 clusters); **23 untracked vault files + 2 new untracked directories**: 8 × `02-Clients/Agents/区域-2026-0807.md` distributors-rebuild + `_known_associations.md` association index + **the first entry in the new `Review/` subfolder** (`04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md` — Zhou 2023 computer vision + microfluidics, Robin deep-read in progress, still-uncommitted at the 2026-08-17 fetch) + `__pycache__/...pyc` Python build noise + **NEW** `celvivo_commercial/1331651_20260630_131201.pdf` (6-30 quote PDF migrated into new folder) + **NEW** `templates/类器官IRB申请清单.md` v1.0 (180 lines, derived from the Guo 2026 ethics deep-read — **first customer-facing template produced from a single deep-read**); wiki-side carries **9 uncommitted synthesis-layer edits** (down from 10 at the 2026-08-15 fetch — `sources/index.md` got committed in `151d22b`) accumulated across the prior HN-1 2026-08-13 + HN-1 2026-08-15 + HN-1 2026-08-16 + HN-1 2026-08-17 + web-search-1 2026-08-15 + web-search-1 2026-08-17 + git-repo-1 2026-08-13 + git-repo-1 2026-08-15 + this git-repo-1 2026-08-17 runs; **operational issue carries forward** — the `2507925` 2026-08-15 sources-sync count-data wipe (NocoDB 6614 → 0 records, Wiki.js 83 → 0 unique pages, RAGFlow landing 200 → 000) is now re-applied by the `997b648` 2026-08-16 sources-sync and the `be49285` 2026-08-17 sources-sync (NocoDB / Wiki.js / RAGFlow count values stay zero across all 3 sources-syncs); the on-disk source configs are unaffected; data is recoverable from `git show 1737454:sources/nocodb.md` etc. — recorded for traceability on `/sources/git-repo.md` Notable-entity § "2026-08-15 sources-sync bug" and on each affected `/sources/{nocodb,ragflow,seafile,wikijs}.md` page; the synthesis layer (themes / commitments / open-questions / personal-logistics) is independent of the source-page counters and is not affected)
|
||||
- **Project / people / company pages** — only created when durable entities emerge from ingested data
|
||||
|
||||
These are intentionally blank until there is real evidence to put in them. Populating them with placeholders would dilute the synthesis layer..esis layer..sis platform 4-commit LDR cycle** (`e542c977` adds file 186 lines → `8699a154` page 946 9 项 SOP 重写版 105+/122- → `aacba7aa` frontmatter title 改中文 1 line → `297f106d` page 934 修齐 5+/4-) — **net-new external evidence** (DOI 10.1038/s41598-026-42990-2, PMID 41857098, mouse liver 3 轨道 Hep-Orgs + Cho-Orgs + HSC + DAPT+Dex P1-P10 长程成熟 + TGFβ 激活体外纤维化模型; Wiki.js Id=1716, NocoDB Id=770); **23 untracked vault files** unchanged from the 2026-08-13 fetch (no new untracked files in the 24-hour window) — including 8 × `02-Clients/Agents/区域-2026-0807.md` distributors-rebuild + `_known_associations.md` association index + **the first entry in the new `Review/` subfolder** (`04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md` — Zhou 2023 computer vision + microfluidics, Robin deep-read in progress, still-uncommitted at the 2026-08-15 fetch) + `__pycache__/...pyc` Python build noise; wiki-side carries **10 uncommitted synthesis-layer edits** accumulated across the prior HN-1 2026-08-13 + HN-1 2026-08-15 + web-search-1 2026-08-15 + this git-repo-1 2026-08-15 runs; **one operational issue surfaced this run** — the `2507925` 2026-08-15 sources-sync committed empty count values for NocoDB / SeaFile / Wiki.js / RAGFlow (NocoDB 6614 → 0 records, Wiki.js 83 → 0 unique pages, RAGFlow landing 200 → 000); the on-disk source configs are unaffected; data is recoverable from `git show 1737454:sources/nocodb.md` etc. — recorded for traceability on `/sources/git-repo.md` Notable-entity § "2026-08-15 sources-sync bug" and on each affected `/sources/{nocodb,ragflow,seafile,wikijs}.md` page; the synthesis layer (themes / commitments / open-questions / personal-logistics) is independent of the source-page counters and is not affected)
|
||||
|
||||
+4
-4
@@ -14,7 +14,7 @@ Per-connector evidence indexes. Each connector gets its own page (for example `g
|
||||
| Connector | Page | Status |
|
||||
| --- | --- | --- |
|
||||
| Hacker News (`hackernews-1`, LLM-agent topics) | [/sources/hackernews.md](/sources/hackernews.md) | active |
|
||||
| Git repo (`git-repo-1`, Obsidian vault + OpenWiki wiki) | [/sources/git-repo.md](/sources/git-repo.md) | active (last 2026-08-15 18:07 UTC) |
|
||||
| Git repo (`git-repo-1`, Obsidian vault + OpenWiki wiki) | [/sources/git-repo.md](/sources/git-repo.md) | active (last 2026-08-17 18:09 UTC — 7 new vault commits since 2026-08-15: Quintard 2024 + Guo 2026 LDR cycles + 2 new untracked dirs `celvivo_commercial/` + `templates/`; 4 new wiki commits since 2026-08-15 + 1 new wiki file `sources/openwiki-version-drift.md`) |
|
||||
| Web Search (`web-search-1`, Tavily) | [/sources/web-search.md](/sources/web-search.md) | active (latest pull 2026-08-03; 2026-08-08, 2026-08-10, 2026-08-12, and 2026-08-15 update attempts skipped — connector not enabled, `TAVILY_API_KEY` missing) |
|
||||
|
||||
Additional connectors appear here automatically once they are authenticated and ingested at least once.
|
||||
@@ -27,9 +27,9 @@ Additional connectors appear here automatically once they are authenticated and
|
||||
| Slack | not configured | `openwiki auth slack` | Needs `search:read` for definitive self-message search; otherwise falls back to recent conversations. |
|
||||
| Notion | not configured | Notion MCP credentials | Discovery via `openwiki_list_mcp_tools`; do not guess tool names. |
|
||||
| X / Twitter | not configured | `OPENWIKI_X_ACCESS_TOKEN` via `openwiki auth x` | Streams: `home_timeline`, `user_posts`, `mentions`, `bookmarks`, `list_posts`. |
|
||||
| Web Search | **active** (`web-search-1`) | `TAVILY_API_KEY` (currently empty) | Tavily via LangChain; reads configured queries. Latest successful pull 2026-08-03 18:08 UTC; the 2026-08-08, 2026-08-10, 2026-08-12, and 2026-08-15 update attempts were skipped because the connector was not enabled in the runtime registry. Evidence at [/sources/web-search.md](/sources/web-search.md). |
|
||||
| Hacker News | **active** (`hackernews-1`) | _(public, no auth)_ | Public feeds (`top`, `new`, `best`) + Algolia HN search queries. Source-specific query set: `organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents` (LLM-agent topics per the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories"). Last successful pull 2026-08-16 18:00 UTC — fifth consecutive "no promotable hits" pull under the 6-query set (empty-pulls-on-vendor-queries is normal cadence, not an outage). Evidence at [/sources/hackernews.md](/sources/hackernews.md). |
|
||||
| Git repo | **active** (`git-repo-1`) | local repo path | Local Obsidian vault at `/home/ldw/workspace` + OpenWiki wiki at `/home/ldw/.openwiki/wiki` (two configured repos per `~/.openwiki/connectors/git-repo/config.json`). Writes compact manifest; repo itself is source of truth. Evidence at [/sources/git-repo.md](/sources/git-repo.md). Last updated 2026-08-15 18:07 UTC. |
|
||||
| Web Search | **active** (`web-search-1`) | `TAVILY_API_KEY` (currently empty) | Tavily via LangChain; reads configured queries. Latest successful pull 2026-08-03 18:08 UTC; the 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, and 2026-08-17 update attempts were skipped because the connector was not enabled in the runtime registry. Evidence at [/sources/web-search.md](/sources/web-search.md). |
|
||||
| Hacker News | **active** (`hackernews-1`) | _(public, no auth)_ | Public feeds (`top`, `new`, `best`) + Algolia HN search queries. Source-specific query set: `organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents` (LLM-agent topics per the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories"). Last successful pull 2026-08-17 18:00 UTC — sixth pull since 2026-08-07 to have an empty / noise-only Algolia lane on vendor queries (after the 2026-08-08 03:15 + 2026-08-08 18:00 + 2026-08-13 + 2026-08-15 + 2026-08-16 fully-zero pulls and the 2026-08-10 + 2026-08-12 noise-only pulls; empty-pulls-on-vendor-queries is normal cadence, not an outage). Evidence at [/sources/hackernews.md](/sources/hackernews.md). |
|
||||
| Git repo | **active** (`git-repo-1`) | local repo path | Local Obsidian vault at `/home/ldw/workspace` + OpenWiki wiki at `/home/ldw/.openwiki/wiki` (two configured repos per `~/.openwiki/connectors/git-repo/config.json`). Writes compact manifest; repo itself is source of truth. Evidence at [/sources/git-repo.md](/sources/git-repo.md). Last updated 2026-08-17 18:09 UTC — 7 new vault commits since 2026-08-15 (Quintard 2024 + Guo 2026 LDR cycles; 2 new untracked dirs `celvivo_commercial/` + `templates/`); 4 new wiki commits since 2026-08-15 + 1 new wiki file `sources/openwiki-version-drift.md`. |
|
||||
|
||||
## How new source pages get created
|
||||
|
||||
|
||||
+315
-93
@@ -1,10 +1,10 @@
|
||||
---
|
||||
type: "Reference"
|
||||
title: "Git repo — evidence index (Obsidian vault, Robin)"
|
||||
description: "Compact manifest of Robin's Obsidian vault + the local OpenWiki wiki, ingested through the local git-repo connector. Two configured repos: obsidian-vault at /home/ldw/workspace (main branch, HEAD 297f106d, 2026-08-12, unchanged across the 2026-08-13 / 2026-08-15 fetches) and openwiki-wiki at /home/ldw/.openwiki/wiki (main branch, HEAD 2507925, 2026-08-15). This page is a navigation index — content ingestion (paper deep reads, sales scripts, customer files) happens via the Hermes skill and RAGFlow, not here."
|
||||
description: "Compact manifest of Robin's Obsidian vault + the local OpenWiki wiki, ingested through the local git-repo connector. Two configured repos: obsidian-vault at /home/ldw/workspace (main branch, HEAD a4fa5a32, 2026-08-16, 7 new vault commits in the 2026-08-15T18:07Z → 2026-08-17T18:09Z 48-hour window) and openwiki-wiki at /home/ldw/.openwiki/wiki (main branch, HEAD be49285, 2026-08-17). This page is a navigation index — content ingestion (paper deep reads, sales scripts, customer files) happens via the Hermes skill and RAGFlow, not here."
|
||||
resource: "~/.openwiki/connectors/git-repo/config.json"
|
||||
tags: [git-repo, evidence, vault, openwiki-wiki, source, 2026-08-15, 2026-08-13]
|
||||
timestamp: 2026-08-15T18:07:49Z
|
||||
tags: [git-repo, evidence, vault, openwiki-wiki, source, 2026-08-17, 2026-08-15, 2026-08-13]
|
||||
timestamp: 2026-08-17T18:09:32Z
|
||||
---
|
||||
|
||||
# Git repo — evidence index (Obsidian vault + OpenWiki wiki)
|
||||
@@ -22,53 +22,72 @@ help locate things in the vault, not summarize their content.
|
||||
`~/.openwiki/connectors/git-repo/config.json`)
|
||||
- **Configured repos:**
|
||||
- `obsidian-vault` → `/home/ldw/workspace` (Robin Obsidian vault, on
|
||||
`main`, HEAD `297f106d2b137af3480261052ff080cbc48d5b48` as of
|
||||
2026-08-12 — unchanged across the 2026-08-13 and 2026-08-15 fetches,
|
||||
0 new vault commits in either 24-hour window).
|
||||
`main`, HEAD `a4fa5a323d6dcabeb9eccad49e636ee6ba5f87a6` as of
|
||||
2026-08-16 +0800 — 7 new vault commits in the
|
||||
2026-08-15T18:07Z → 2026-08-17T18:09Z 48-hour window: the 2026-08-16
|
||||
**Quintard 2024 Nat Commun 4-commit LDR cycle** (`0fc8db24` adds
|
||||
file 189 lines → `290e9635` -v2 修图床/双 H1/落款 → `24c713de`
|
||||
-v3 Wiki.js 自带图床 6 张图 → `4073abf4` -v4 转发语标题/落款加粗/删
|
||||
3Brain) + the 2026-08-16 **Guo 2026 Front Cell Dev Biol 3-commit LDR
|
||||
cycle** (`2e6f5989` adds file 170 lines → `00f824f2` -v2 修图床 →
|
||||
`a4fa5a32` -v3 补 Fig 1) — the first time two new paper LDR cycles
|
||||
land within the same 48-hour window since the 2026-07-28 / 2026-07-29
|
||||
Parate / Lee / Hodge cluster. The 2026-08-12 Liang 2026 4-commit LDR
|
||||
cycle remains the prior baseline cluster).
|
||||
- `openwiki-wiki` → `/home/ldw/.openwiki/wiki` (the OpenWiki knowledge
|
||||
base itself, on `main`, HEAD `2507925e27b83b4f9d2e6f3b9c939d081a90f9f2`
|
||||
as of 2026-08-15T02:31 +0800 — 4 new wiki-side commits in the
|
||||
2026-08-14T18:08Z → 2026-08-15T18:07Z window: `021e929` daily
|
||||
update 2026-08-14 + `6258717` sources-sync 2026-08-14 + `173b58c`
|
||||
daily update 2026-08-15 + `2507925` sources-sync 2026-08-15).
|
||||
base itself, on `main`, HEAD `be4928553364a654b888807a44438b738072c2ce`
|
||||
as of 2026-08-17T +0800 — 4 new wiki-side commits in the
|
||||
2026-08-15T18:07Z → 2026-08-17T18:09Z window: `151d22b` daily
|
||||
update 2026-08-16 + `997b648` sources-sync 2026-08-16 + `5c70881`
|
||||
daily update 2026-08-17 + `be49285` sources-sync 2026-08-17; the
|
||||
`5c70881` daily update also created the new `sources/openwiki-version-drift.md`
|
||||
auto-generated page).
|
||||
- **Auth:** local paths only — no remote, no credentials.
|
||||
- **Latest fetch:** `2026-08-15T18:07:49Z` (raw manifest
|
||||
`~/.openwiki/connectors/git-repo/raw/2026-08-15T18-07-49-711Z/manifest.json`).
|
||||
- **Latest fetch:** `2026-08-17T18:09:32Z` (raw manifest
|
||||
`~/.openwiki/connectors/git-repo/raw/2026-08-17T18-09-32-895Z/manifest.json`).
|
||||
- **Source config:** `~/.openwiki/connectors/git-repo/config.json`
|
||||
- **State:** `~/.openwiki/connectors/git-repo/state.json` records
|
||||
`latestIds` per repo; the 2026-08-15 fetch observed vault HEAD
|
||||
unchanged at `297f106d` (no new vault commits in the 24-hour window —
|
||||
the 2026-08-12 Liang 2026 cluster of 4 commits is still the most
|
||||
recent vault activity, and the 2026-08-13 cluster of 3 frontmatter-hygiene
|
||||
+ MOC-discipline commits + the 2026-08-11 cluster of 4 PMID deep-read
|
||||
commits are all already merged into `297f106d`) and bumped
|
||||
`openwiki-wiki` from `1737454` (2026-08-13) to `2507925` (2026-08-15,
|
||||
4 new commits — `021e929` + `6258717` + `173b58c` + `2507925`).
|
||||
`latestIds` per repo; the 2026-08-17 fetch observed vault HEAD
|
||||
bumped from `297f106d` (2026-08-15 fetch) to `a4fa5a32` (7 new
|
||||
vault commits in the 48-hour window) and bumped `openwiki-wiki`
|
||||
from `2507925` (2026-08-15 fetch) to `be49285` (4 new wiki commits
|
||||
in the same 48-hour window, plus 1 new wiki-side file
|
||||
`sources/openwiki-version-drift.md`).
|
||||
|
||||
## obsidian-vault — working-tree status (2026-08-15)
|
||||
## obsidian-vault — working-tree status (2026-08-17)
|
||||
|
||||
- **Branch:** `main`
|
||||
- **HEAD:** `297f106d2b137af3480261052ff080cbc48d5b48` (vault HEAD
|
||||
**unchanged** across the 2026-08-13 and 2026-08-15 fetches — 0 new
|
||||
commits in either 24-hour window; the 2026-08-12 Liang 2026 cluster of
|
||||
4 commits remains the most recent vault activity).
|
||||
- **Ahead of origin/main:** 13 commits new since 2026-08-03 fetch (same
|
||||
count as the 2026-08-13 fetch — the 2026-08-12 Liang 2026 cluster of 4
|
||||
commits is still the most recent vault activity).
|
||||
- **Dirty:** yes — the untracked file set is **unchanged** from the
|
||||
2026-08-13 fetch (no new untracked files appeared in the 2026-08-15
|
||||
24-hour window). The set is: 8 × `02-Clients/Agents/区域-2026-0807.md`
|
||||
distributor-rebuild files (per the 2026-08-07 Hermes hook 4 sweep) +
|
||||
the existing 15 working-folder files (Parfitt 2024 DJ1 LOF midbrain +
|
||||
Liu2026 / Miao2025 v2 / Miao2025 vascularized / Microbioreactor 2026 /
|
||||
`__pycache__/literature_deepread_v6.cpython-312.pyc` / `dify精读进度-20260805.md`
|
||||
/ `literature_deepread_v6.py` / `obsidian-vault/04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md`
|
||||
- **HEAD:** `a4fa5a323d6dcabeb9eccad49e636ee6ba5f87a6` (vault HEAD
|
||||
**bumped** from `297f106d` across the 2026-08-17 fetch — **7 new
|
||||
commits** in the 2026-08-15T18:07Z → 2026-08-17T18:09Z 48-hour
|
||||
window: the 2026-08-16 **Quintard 2024 Nat Commun 4-commit LDR cycle**
|
||||
+ the 2026-08-16 **Guo 2026 Front Cell Dev Biol 3-commit LDR cycle**.
|
||||
Two new paper LDR cycles in the same 48-hour window is the first time
|
||||
this pattern has occurred since the 2026-07-28 / 2026-07-29 Parate /
|
||||
Lee / Hodge cluster).
|
||||
- **Ahead of origin/main:** 20 commits new since 2026-08-03 fetch (was
|
||||
13 at the 2026-08-15 fetch; the +7 delta is the Quintard 2024 +
|
||||
Guo 2026 clusters).
|
||||
- **Dirty:** yes — the untracked file set **+2 new entries** in the
|
||||
2026-08-17 48-hour window: `celvivo_commercial/1331651_20260630_131201.pdf`
|
||||
(the 6-30 quote PDF, moved into a new folder) + `templates/类器官IRB申请清单.md`
|
||||
(the IRB application checklist derived from Guo 2026; 180 lines; 7
|
||||
mandatory points + 5 customer Q&A + China vs International flow + 10
|
||||
attachments; Robin's first customer-facing template derived from a
|
||||
single deep-read). The carry-forward untracked set is unchanged: 8
|
||||
× `02-Clients/Agents/区域-2026-0807.md` distributor-rebuild files
|
||||
(per the 2026-08-07 Hermes hook 4 sweep) + the existing 14 working-
|
||||
folder files (Parfitt 2024 DJ1 LOF midbrain + Liu2026 / Miao2025 v2 /
|
||||
Miao2025 vascularized / Microbioreactor 2026 / `__pycache__/literature_deepread_v6.cpython-312.pyc`
|
||||
/ `dify精读进度-20260805.md` / `literature_deepread_v6.py` /
|
||||
`obsidian-vault/04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md`
|
||||
/ `obsidian-vault/rustdesk-selfhosted-2026-08-05.md` /
|
||||
`retinal_organoid_deep_read_2026-08-07.md` / `文悦精读流水线.yml` + v2/v3/v4/v5-clean
|
||||
variants). The **`Review/zhou2023_computer_vision_microfluidics.md`
|
||||
first entry in the new `Review/` subfolder** is still **untracked**
|
||||
(Robin has not yet committed it) — the structural signal carried
|
||||
forward from the 2026-08-13 fetch.
|
||||
forward from the 2026-08-13 fetch and is **now joined** by 2 new
|
||||
untracked working-tree directories (`celvivo_commercial/` + `templates/`).
|
||||
- **Working-tree status (raw manifest, abbreviated):**
|
||||
|
||||
| Status | Path |
|
||||
@@ -77,7 +96,9 @@ help locate things in the vault, not summarize their content.
|
||||
| `M` (committed 2026-08-12, `8699a154`) | same Liang 2026 file — page 946 9 项 SOP 重写版 (105+/122- lines) |
|
||||
| `M` (committed 2026-08-12, `aacba7aa`) | same Liang 2026 file — frontmatter title 改中文 + 与正文 H1 一致 (1-line touch) |
|
||||
| `M` (committed 2026-08-12, `297f106d`) | same Liang 2026 file — 修齐 page 934 标杆 (H1 去括号/元数据用bold/📄PDF文件名, 5+/4- lines) |
|
||||
| `M` (committed 2026-08-10) | `04-Literature/Deep-Reads/Organoid/2026-07-29_Organoids_disease_modeling_treatment_2026_review.md` (Phase A batch frontmatter — `volume` / `pages` / `authors` array; also touched by `6b717aef` for related back-link) |
|
||||
| `A` (committed 2026-08-16, `a4fa5a32`) | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` — **NEW external evidence** (Guo Z, Zhang N 2026 Front Cell Dev Biol DOI 10.3389/fcell.2026.1721946 — IRB / ethics systematic review; Wiki ID 1724, NocoDB Id 3298, 170 lines + 3 张真图; "与我们的产品" table lists CelVivo ClinoStar ⭐⭐⭐⭐ [临床转化类器官的伦理合规——7 大要点直接适用 IRB 申请] + Mimetas OrganoPlate ⭐⭐⭐⭐ [类器官 + 免疫细胞共培养伦理审查依据] + Emulate Organ-Chip ⭐⭐⭐; 3 commits `2e6f5989` → `00f824f2` → `a4fa5a32` = adds → -v2 修图床 → -v3 补 Fig 1) |
|
||||
| `A` (committed 2026-08-16, `0fc8db24`) | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` — **NEW external evidence** (Quintard C et al. 2024 Nat Commun DOI 10.1038/s41467-024-45710-4 — microfluidic platform for vascularized organoid chips; Wiki IDs 1719/1720/1722, NocoDB Id 3297; 4 commits `0fc8db24` → `290e9635` → `24c713de` → `4073abf4` = adds 189 lines → -v2 修图床/双 H1/落款 → -v3 Wiki.js 自带图床 6 张图 → -v4 转发语标题/落款加粗/删 3Brain; "与我们的产品" table lists Mimetas OrganoPlate ⭐⭐⭐⭐ [直接对标: Phaseguide 微流控技术用于血管化/肾/肠 organ-on-chip] + CelVivo ClinoStar ⭐⭐⭐ [类器官前段成熟期培养: BVO 在 hiPSC 分化到 day 15 需要悬浮旋转培养, ClinoStar 是该步骤的金标准; day 15 后才转入芯片, ClinoStar 是完整工作流的前置] + Emulate Organ-Chip ⭐⭐⭐) |
|
||||
| `M` (committed 2026-08-10) | `04-Literature/Deep-Reads/Organoid/2026-07-29_Organoids_disease_modeling_treatment_2026_review.md` (Phase A batch frontmatter — `volume` / `pages` / `authors` array; also touched by `6b717aef` for related back-link) |
|
||||
| `M` (committed 2026-08-10) | `CelVivo_精读报告_04_bioRxiv_PAH_Metabolomics.md` (Phase A batch frontmatter — `volume` / `pages` / `authors` array; also touched by `6b717aef`) |
|
||||
| `M` (committed 2026-08-10) | `obsidian-vault/04-Literature/Deep-Reads/3Brain/shin-2024-thalamocortical-organoids-22q11ds.md` (Phase A batch frontmatter; also touched by `6b717aef`) |
|
||||
| `M` (committed 2026-08-10) | `obsidian-vault/04-Literature/Deep-Reads/Cells/fernandez-vallone-2026-thsdc-brain-organoids.md` (Phase A batch frontmatter; also touched by `6b717aef`) |
|
||||
@@ -86,6 +107,8 @@ help locate things in the vault, not summarize their content.
|
||||
| `M` (committed 2026-08-10) | `04-Literature/Deep-Reads/wang2024-org-on-chip.md` (方案 2 样品 — 6 frontmatter fields + 7 alt descriptions; also touched by `6b717aef`) |
|
||||
| `A` (committed 2026-08-10) | `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (方案 1 — **first MOC file**; 95 lines; 沙牛《AI 时代的 Obsidian 公开课》课时 1 pattern; `related:` already lists `[[MOC-3Brain-HD-MEA]]` as a forward link) |
|
||||
| `??` (untracked) | `02-Clients/Agents/全国经销商地图-2026-0807.md` + 7 区域 `*2026-0807.md` files (8-07 distributor baseline refresh — see below) |
|
||||
| `??` (untracked, **NEW 2026-08-17**) | `celvivo_commercial/1331651_20260630_131201.pdf` — **NEW** untracked directory; the 6-30 quote PDF Robin migrated into a new `celvivo_commercial/` folder; companion to the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree |
|
||||
| `??` (untracked, **NEW 2026-08-17**) | `templates/类器官IRB申请清单.md` — **NEW** untracked directory; the IRB application checklist derived from the Guo 2026 ethics-review deep-read (180 lines; 7 mandatory points [样本来源/知情同意/数据隐私/共培养主体性/3R 动物福利/跨境监管/长期保存与终止使用] + 5 customer Q&A + China vs International flow table + 10 attachments + 7 citations); Robin's **first customer-facing template** derived from a single deep-read — materializes the "Robin 业务定位: 类器官厂家给三甲医院 IRB 申请的标准模板 + Robin 客户培训材料核心" framing from the Guo 2026 deep-read |
|
||||
| `??` (untracked) | `04-Literature/Deep-Reads/Brain/2026-08-06_Parfitt_GM_et_al_NatCommun_2024_DJ1_LOF_midbrain_organoid_PD.md` |
|
||||
| `??` (untracked) | `Liu2026_NBME_shape_conformal_organoid.md` |
|
||||
| `??` (untracked) | `Miao2025_Cell_v2.md` |
|
||||
@@ -111,6 +134,13 @@ help locate things in the vault, not summarize their content.
|
||||
|
||||
| Date | Hash | Note |
|
||||
| --- | --- | --- |
|
||||
| 2026-08-16 | `a4fa5a32` | **literature: review 类 Guo 2026 -v3 补 Fig 1** — in-place update ID 1724, 3 张图全 |
|
||||
| 2026-08-16 | `00f824f2` | **literature: review 类 Guo 2026 -v2 修图床** — in-place update ID 1724, 加 2 张 Wiki.js 自带图 |
|
||||
| 2026-08-16 | `2e6f5989` | **literature: 精读 Guo 2026 Front Cell Dev Biol - 类器官伦理审查** (review 类, Wiki ID 1724, NocoDB Id 3298) — **NEW external evidence** (类器官研究 IRB / 伦理审查 7 大强制要点系统综述, 嘉兴市第一医院 + 嘉兴大学医学院视角) |
|
||||
| 2026-08-16 | `4073abf4` | **literature: 精读 Quintard 2024 -v4** — 转发语标题/落款加粗/删3Brain |
|
||||
| 2026-08-16 | `24c713de` | **literature: 精读 Quintard 2024 -v3 Wiki.js 自带图床** (ID 1722, 6 张图永久) |
|
||||
| 2026-08-16 | `290e9635` | **literature: 精读 Quintard 2024 -v2 修图床/双 H1/落款** (Wiki ID 1720) |
|
||||
| 2026-08-16 | `0fc8db24` | **literature: 精读 Quintard 2024 Nat Commun - 微流控血管化类器官芯片** (Wiki ID 1719, NocoDB Id 3297) — **NEW external evidence** (10 通道并行微流控 + hiPSC-BVO 30 天功能性灌注培养 + 跨类器官验证) |
|
||||
| 2026-08-12 | `297f106d` | **literature: 修齐 page 934 标杆** — H1 去括号 / 元数据用 bold / 📄PDF 文件名 (Liang 2026 v3) |
|
||||
| 2026-08-12 | `aacba7aa` | **literature: frontmatter title 改中文 + 与正文 H1 一致** (Liang 2026 v2) |
|
||||
| 2026-08-12 | `8699a154` | **literature: Liang 2026 Sci Rep liver organoid fibrosis - page 946 9 项 SOP 重写版** (Liang 2026 v2; 105+/122- lines; core-question / research-model / 6-finding 3-stage tables / 6 SeaFile Fig / "与我们的产品" 4-star / 4-paper refs / 转发语 / 完整落款) |
|
||||
@@ -140,6 +170,60 @@ help locate things in the vault, not summarize their content.
|
||||
| 2026-07-28 | `2718e46d` | feat(literature): Parate 2020 SCRT — PEMF 增强 MSC 旁分泌功能促软骨再生 |
|
||||
| 2026-07-28 | `032de92f` | feat: 精读 Lee 2025 Front Vet Sci 犬脂肪源 MSC 3D 球体 |
|
||||
|
||||
The **2026-08-16 cluster** is a **two-paper LDR cycle on the same day**
|
||||
covering both an **organ-on-chip microfluidic platform paper** and an
|
||||
**organoid ethical-review systematic-review paper**:
|
||||
|
||||
- **Quintard C et al. (2024) Nat Commun DOI 10.1038/s41467-024-45710-4**
|
||||
— a microfluidic platform for vascularized organoids-on-chip. The
|
||||
paper establishes: (i) 10-channel parallel microfluidic chip (COC
|
||||
热压成型, U 型捕获位 300-800 µm 可调); (ii) fibrin + Matrigel hydrogel
|
||||
with Landau-Levich-Bretherton 效应 → 100% 捕获效率 in 10 sec per
|
||||
channel; (iii) hiPSC-derived blood vessel organoids (BVO, day 15)
|
||||
+ GFP-HUVEC + 纤维细胞共培养 → 30 天功能性灌注培养; (iv) 壁剪切速率
|
||||
27-2000 s⁻¹, mean 134-531 s⁻¹ (与人体毛细血管生理范围 50-1900 s⁻¹
|
||||
完美匹配); (v) 层级化血管: 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管.
|
||||
The 4 commits are the same single file
|
||||
`obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md`
|
||||
walked through Robin's standard LDR cycle: (a) **`0fc8db24`** adds
|
||||
the file (189 lines, single-pass entry); (b) **`290e9635`** rewrites
|
||||
to -v2 修图床/双 H1/落款; (c) **`24c713de`** adds -v3 Wiki.js 自带
|
||||
图床 6 张图 (永久); (d) **`4073abf4`** is the -v4 转发语标题/落款
|
||||
加粗 + 删 3Brain 工具名硬门槛合规修正. The "与我们的产品" table on
|
||||
the paper lists **Mimetas OrganoPlate ⭐⭐⭐⭐ (直接对标: Phaseguide
|
||||
微流控技术)** + **CelVivo ClinoStar ⭐⭐⭐ (类器官前段成熟期培养:
|
||||
BVO 在 hiPSC 分化到 day 15 需要悬浮旋转培养, ClinoStar 是该步骤
|
||||
的金标准; day 15 后才转入芯片, ClinoStar 是完整工作流的前置)** +
|
||||
**Emulate Organ-Chip ⭐⭐⭐**.
|
||||
- **Guo Z, Zhang N (2026) Front Cell Dev Biol DOI 10.3389/fcell.2026.1721946**
|
||||
— an IRB / ethical-review systematic-review paper for organoid
|
||||
biomedical research. The paper establishes: (i) **7 大强制要点**
|
||||
(样本来源合法性 / 捐赠者知情同意 [unlimited expansion / long-term
|
||||
cryopreservation / inter-lab sharing / cross-border / future
|
||||
unspecified research / commercial use / withdrawal mechanism] /
|
||||
数据隐私与去标识化 / 共培养产物主体性评估 [Guo 2026 首次提出] /
|
||||
动物福利 3R 原则 / 跨境监管合规 [中国 / 美国 / 欧盟 / 日本 / 韩国
|
||||
对照表] / 长期保存与终止使用); (ii) **中国 IRB 实务视角 + 国际
|
||||
ISSCR / GDPR / OHRP 双重参照** (作者团队 = 嘉兴市第一医院医学伦理
|
||||
委员会 + 嘉兴大学医学院, 中国 IRB 实践者); (iii) **共培养产物
|
||||
"新伦理实体" 框架** = 类器官 + 免疫细胞共培养 (CAR-T 培养) 不构成
|
||||
"新生物体" 但构成 "新伦理实体", 需要独立审查. The 3 commits are
|
||||
the same single file
|
||||
`obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md`
|
||||
walked through Robin's standard LDR cycle: (a) **`2e6f5989`** adds
|
||||
the file (170 lines, single-pass entry); (b) **`00f824f2`** -v2 修
|
||||
图床 (加 2 张 Wiki.js 自带图); (c) **`a4fa5a32`** -v3 补 Fig 1
|
||||
(3 张图全) — Fig 1 is the "类器官共培养模型" 概念图 (Robin 8-16
|
||||
实战反思: 综述类概念图通常较小, 提取阈值要从 0KB 起步全收, 再按
|
||||
caption 关联; 之前 >200KB 过滤漏了 Fig 1). The "与我们的产品"
|
||||
table on the paper lists **CelVivo ClinoStar ⭐⭐⭐⭐ (临床转化类
|
||||
器官的伦理合规——本文 7 大要点直接适用于 ClinoStar 客户 IRB 申请;
|
||||
Robin 推广 ClinoStar 给三甲医院时, 可附带本框架作为增值)** +
|
||||
**Mimetas OrganoPlate ⭐⭐⭐⭐ (类器官共培养芯片的伦理审查依据——
|
||||
Mimetas 主打"类器官 + 免疫细胞共培养", 本文主题 B 的共培养伦理
|
||||
框架直接适用)** + **Emulate Organ-Chip ⭐⭐⭐ (类器官 + 微流控
|
||||
芯片的跨境监管参考)**.
|
||||
|
||||
The **2026-08-12 cluster** is a **single-paper LDR cycle** on
|
||||
**Liang Y et al. (2026) Sci Rep DOI 10.1038/s41598-026-42990-2** — a
|
||||
mouse liver organoid platform paper from 澳门科技大学 + 香港大学 that
|
||||
@@ -175,6 +259,21 @@ working tree this fetch:
|
||||
— the **first entry in a new `Review/` subfolder** (see the
|
||||
Notable-entity section below).
|
||||
|
||||
**7 new vault commits landed in the 2026-08-15T18:07Z →
|
||||
2026-08-17T18:09Z window** — the vault HEAD bumped from `297f106d`
|
||||
to `a4fa5a32`. The two 2026-08-16 LDR cycles (Quintard 2024
|
||||
microfluidic organ-on-chip + Guo 2026 organoid ethics systematic
|
||||
review) are the **first time since the 2026-07-28 / 2026-07-29
|
||||
Parate / Lee / Hodge cluster** that two new paper deep-reads landed
|
||||
on `main` in the same 48-hour window. The 2026-08-16 cluster
|
||||
replaces the 2026-08-12 Liang 2026 cluster as the most recent
|
||||
committed vault activity. Two new untracked directories appeared in
|
||||
the working tree this fetch: `celvivo_commercial/1331651_20260630_131201.pdf`
|
||||
(the 6-30 quote PDF migrated into a new folder) + `templates/类器官IRB申请清单.md`
|
||||
(the IRB application checklist derived from Guo 2026 — Robin's first
|
||||
customer-facing sales ammunition template produced from a single
|
||||
deep-read; see the Notable-entity section below for synthesis).
|
||||
|
||||
The **2026-08-10 cluster** is a **frontmatter-hygiene + MOC-discipline
|
||||
sprint** rather than new external evidence: (a) **Phase A batch**
|
||||
(`d97b39ed`) standardized 6 deep-read notes with the structured 6-field
|
||||
@@ -198,19 +297,18 @@ indexed on [`/sources/literature.md`](/sources/literature.md). The
|
||||
`1614ccf9`) are the 8-step SOP rewrite cycle (v3 → v11) Robin re-ran
|
||||
on the same paper.
|
||||
|
||||
## openwiki-wiki — working-tree status (2026-08-15)
|
||||
## openwiki-wiki — working-tree status (2026-08-17)
|
||||
|
||||
- **Branch:** `main`
|
||||
- **HEAD:** `2507925e27b83b4f9d2e6f3b9c939d081a90f9f2` (the
|
||||
- **HEAD:** `be4928553364a654b888807a44438b738072c2ce` (the
|
||||
`chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts
|
||||
(sources-sync 2026-08-15)` commit — see Notable-entity §
|
||||
"2026-08-15 sources-sync bug" for the count-data wipe this commit
|
||||
carried into the source pages).
|
||||
- **Working-tree state:** 10 modified files (uncommitted — pending next
|
||||
CLI orchestration). The dirty file set is the **accumulated
|
||||
synthesis-layer edits from the prior 3 runs in this same 24-hour
|
||||
window** (HN-1 2026-08-13 + HN-1 2026-08-15 + web-search-1 2026-08-15
|
||||
+ this git-repo-1 2026-08-15 run). The 10 dirty files are:
|
||||
(sources-sync 2026-08-17)` commit — same auto-source-sync job that
|
||||
carried the 2026-08-15 count-data wipe; see Notable-entity §
|
||||
"2026-08-15 sources-sync bug" for the operational note).
|
||||
- **Working-tree state:** 9 modified files (uncommitted — pending next
|
||||
CLI orchestration), **down from 10 at the 2026-08-15 fetch**
|
||||
(the `sources/index.md` from the 2026-08-15 dirty set was committed
|
||||
in the 2026-08-16 daily update `151d22b`). The 9 dirty files are:
|
||||
- `.last-update.json` — CLI metadata, will be updated when this run's
|
||||
`status: complete` lands.
|
||||
- `quickstart.md` — contains the accumulated "Latest update"
|
||||
@@ -222,36 +320,53 @@ on the same paper.
|
||||
+ added frontmatter placeholders to nocodb.md / ragflow.md /
|
||||
seafile.md / wikijs.md during the 2026-08-15 daily update.
|
||||
- `sources/hackernews.md` — accumulated "Latest update —
|
||||
2026-08-15 18:00 UTC" section from the HN-1 2026-08-15 run (Auto-research
|
||||
with codex 232x Faster Kernel flag-for-traceability + Working with AI
|
||||
as Leadership + Yadda 3.0.0 BDD adjacent-off-scope callout section +
|
||||
4th consecutive fully-zero Algolia lane streak note) — landed in
|
||||
uncommitted state during the HN-1 2026-08-15 run.
|
||||
- `sources/index.md` — accumulated description-only edits for
|
||||
nocodb.md / ragflow.md / seafile.md / wikijs.md (frontmatter was
|
||||
re-applied by the 2026-08-15 daily update, description lines
|
||||
removed since they no longer match the placeholder scheme).
|
||||
- `sources/nocodb.md` — frontmatter re-added during the 2026-08-15
|
||||
daily update; **count data wiped** by `2507925` sources-sync
|
||||
(NocoDB went from 6614 → 0 records).
|
||||
- `sources/ragflow.md` — frontmatter re-added during the 2026-08-15
|
||||
daily update; **count data wiped** by `2507925` sources-sync
|
||||
(landing went from 200 → 000).
|
||||
- `sources/seafile.md` — frontmatter re-added during the 2026-08-15
|
||||
daily update; **count data wiped** by `2507925` sources-sync
|
||||
(libraries table emptied).
|
||||
2026-08-15 18:00 UTC" + "Latest update — 2026-08-16 18:00 UTC" +
|
||||
"Latest update — 2026-08-17 18:00 UTC" sections from the prior
|
||||
HN-1 2026-08-15 + HN-1 2026-08-16 + HN-1 2026-08-17 runs
|
||||
(Auto-research with codex 232x Faster Kernel + Anthropic multi-agent
|
||||
+ Stripe/OpenRouter + Copilot Autofix + Qwen 3.8 27B + Agent Mesh
|
||||
flag-for-traceability callouts + the 4th / 5th / 6th consecutive
|
||||
empty / noise-only Algolia lane streak notes) — landed in
|
||||
uncommitted state during the HN-1 runs.
|
||||
- `sources/nocodb.md` — `openwiki_generated: true` placeholder
|
||||
frontmatter auto-applied during the 2026-08-15 daily update +
|
||||
carried forward in 2026-08-16 + 2026-08-17 daily updates; **count
|
||||
data wiped** by `2507925` 2026-08-15 sources-sync (NocoDB went
|
||||
from 6614 → 0 records).
|
||||
- `sources/ragflow.md` — same `openwiki_generated: true` placeholder
|
||||
auto-applied during the 2026-08-15 daily update; **count data
|
||||
wiped** by `2507925` 2026-08-15 sources-sync (landing went from
|
||||
200 → 000).
|
||||
- `sources/seafile.md` — same `openwiki_generated: true` placeholder
|
||||
auto-applied during the 2026-08-15 daily update; **count data
|
||||
wiped** by `2507925` 2026-08-15 sources-sync (libraries table
|
||||
emptied — SeaFile was already empty in `1737454` already — a
|
||||
separate, older cron issue not introduced by `2507925`).
|
||||
- `sources/web-search.md` — accumulated "2026-08-15 attempted
|
||||
update — skipped" section from the web-search-1 2026-08-15 run
|
||||
(4th consecutive skip).
|
||||
- `sources/wikijs.md` — frontmatter re-added during the 2026-08-15
|
||||
daily update; **count data wiped** by `2507925` sources-sync
|
||||
(Wiki.js went from 83 → 0 unique pages; ID range 22..1704 → 0..0).
|
||||
update — skipped" + "2026-08-17 attempted update — skipped"
|
||||
sections from the web-search-1 2026-08-15 + 2026-08-17 runs
|
||||
(5th + 6th consecutive skips on the same code path).
|
||||
- `sources/wikijs.md` — same `openwiki_generated: true` placeholder
|
||||
auto-applied during the 2026-08-15 daily update; **count data
|
||||
wiped** by `2507925` 2026-08-15 sources-sync (Wiki.js went from
|
||||
83 → 0 unique pages; ID range 22..1704 → 0..0).
|
||||
- **Auth:** local path only — no remote, no credentials.
|
||||
- **New file in this window:** `sources/openwiki-version-drift.md`
|
||||
was created in the 2026-08-17 daily update commit `5c70881` (auto-
|
||||
generated page that tracks OpenWiki installed-vs-npm-latest version
|
||||
drift; reports v0.3.1 local → v0.3.3 npm latest as of
|
||||
2026-08-15T20:00:03Z; the page sits on the wiki to surface the
|
||||
drift without an external daemon).
|
||||
- **Auth:** local path only — no remote, no credentials.
|
||||
|
||||
### Recent commits (latest first)
|
||||
|
||||
| Date | Hash | Note |
|
||||
| --- | --- | --- |
|
||||
| 2026-08-17 | `be49285` | chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-17) |
|
||||
| 2026-08-17 | `5c70881` | chore: daily update 2026-08-17 (added `sources/openwiki-version-drift.md` auto-generated page + refreshed HN-1 / web-search-1 / git-repo-1 sections) |
|
||||
| 2026-08-16 | `997b648` | chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-16) |
|
||||
| 2026-08-16 | `151d22b` | chore: daily update 2026-08-16 (committed `sources/index.md` from the 2026-08-15 dirty set; refreshed HN-1 / web-search-1 / git-repo-1 / themes/05-robin-research sections) |
|
||||
| 2026-08-15 | `2507925` | chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-15) — **count-data wipe** (NocoDB 6614 → 0, Wiki.js 83 → 0, RAGFlow landing 200 → 000); see Notable-entity § "2026-08-15 sources-sync bug" |
|
||||
| 2026-08-15 | `173b58c` | chore: daily update 2026-08-15 (added OKF frontmatter to nocodb.md / ragflow.md / seafile.md / wikijs.md) |
|
||||
| 2026-08-14 | `6258717` | chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-14) |
|
||||
@@ -316,14 +431,14 @@ from 2026-08-11 / 2026-08-12 (`7556e31` / `431ee6a` daily +
|
||||
next wiki commit should add a fuller Liang 2026 row when the synthesis
|
||||
pipeline catches up.
|
||||
|
||||
### Summary of last 24 hours
|
||||
### Summary of last 48 hours
|
||||
|
||||
| Window (UTC) | Vault | Wiki |
|
||||
| --- | --- | --- |
|
||||
| 2026-08-13T18:08:25Z → 2026-08-15T18:07:49Z | HEAD `297f106d` → `297f106d` (**0 new commits**; the 2026-08-12 Liang 2026 4-commit LDR cycle remains the most recent vault activity across both 2026-08-13 and 2026-08-15 fetches) | HEAD `1737454` → `2507925` (**4 new commits**: `021e929` daily update 2026-08-14 + `6258717` sources-sync 2026-08-14 + `173b58c` daily update 2026-08-15 + `2507925` sources-sync 2026-08-15) |
|
||||
| **Net new external evidence** | **none** — vault HEAD unchanged, untracked file set unchanged (the `Review/zhou2023_computer_vision_microfluidics.md` first-entry-in-Review/-subfolder is still untracked, carrying forward from the 2026-08-13 fetch) | **none** — synthesis layer only (HN-1 2026-08-13 MCP Memory using OKF refresh + HN-1 2026-08-15 Auto-research with codex flag-for-traceability + web-search-1 2026-08-15 4th-skip streak note all committed earlier; this run's edits are pending the next CLI commit) |
|
||||
| Untracked → committed migrations | none | none — the 10 dirty files (`.last-update.json` + `quickstart.md` + `sources/{README,hackernews,index,nocodb,ragflow,seafile,web-search,wikijs}.md`) are uncommitted synthesis edits accumulated across the prior HN-1 2026-08-13 + HN-1 2026-08-15 + web-search-1 2026-08-15 + git-repo-1 2026-08-15 runs, awaiting the next CLI commit cycle |
|
||||
| **Operational issue surfaced this run** | n/a | **`2507925` 2026-08-15 sources-sync bug**: this sync committed empty NocoDB / SeaFile / Wiki.js / RAGFlow count values (NocoDB 6614 → 0, Wiki.js 83 → 0, RAGFlow landing 200 → 000). The on-disk `~/.openwiki/connectors/web-search/config.json` is unaffected — this is a wiki-side CRON issue with the auto-source-sync job, not a connector config issue. Recorded for traceability on `/sources/git-repo.md` Notable-entity § "2026-08-15 sources-sync bug" and on each affected `/sources/{nocodb,ragflow,seafile,wikijs}.md` page (each of those pages now shows `上次同步: 2026-08-14T18:30:42Z` — the prior successful sync — plus zero / null / 000 count values from the failed 2026-08-15 sync). The data is recoverable from `git show 8ddc6d9:sources/nocodb.md` etc. for any future recovery commit |
|
||||
| 2026-08-15T18:07:49Z → 2026-08-17T18:09:32Z | HEAD `297f106d` → `a4fa5a32` (**7 new commits**: `0fc8db24` + `290e9635` + `24c713de` + `4073abf4` Quintard 2024 Nat Commun microfluidic vascularized organoid chip 4-commit LDR cycle + `2e6f5989` + `00f824f2` + `a4fa5a32` Guo 2026 Front Cell Dev Biol organoid ethics systematic review 3-commit LDR cycle — **first time since the 2026-07-28 / 2026-07-29 Parate / Lee / Hodge cluster that two new paper deep-reads landed on `main` in the same 48-hour window**) | HEAD `2507925` → `be49285` (**4 new commits**: `151d22b` daily update 2026-08-16 + `997b648` sources-sync 2026-08-16 + `5c70881` daily update 2026-08-17 + `be49285` sources-sync 2026-08-17) |
|
||||
| **Net new external evidence** | **2 new paper deep-reads**: Quintard 2024 Nat Commun microfluidic vascularized organoid chip + Guo 2026 Front Cell Dev Biol organoid ethics systematic review. **2 new untracked directories**: `celvivo_commercial/1331651_20260630_131201.pdf` (the 6-30 quote PDF migrated into a new folder) + `templates/类器官IRB申请清单.md` (the IRB application checklist derived from Guo 2026 — Robin's first customer-facing sales ammunition template produced from a single deep-read). The `Review/zhou2023_computer_vision_microfluidics.md` first-entry-in-Review/-subfolder is still untracked, carrying forward from the 2026-08-13 fetch | **1 new wiki file**: `sources/openwiki-version-drift.md` (auto-generated OpenWiki version-drift monitor; v0.3.1 local → v0.3.3 npm latest as of 2026-08-15T20:00:03Z). Synthesis-layer edits accumulated across the prior HN-1 2026-08-13 + HN-1 2026-08-15 + HN-1 2026-08-16 + HN-1 2026-08-17 + web-search-1 2026-08-15 + web-search-1 2026-08-17 + git-repo-1 2026-08-13 + git-repo-1 2026-08-15 runs are pending the next CLI commit cycle |
|
||||
| Untracked → committed migrations | **Quintard 2024 file (4 commits)** + **Guo 2026 file (3 commits)** all moved from absent → committed on `main`; **the 2 new untracked directories** are net-new in this window | **none** of the 9 dirty files were committed in this window (the `sources/index.md` from the 2026-08-15 dirty set was committed by the 2026-08-16 daily update `151d22b`; the remaining 9 dirty files are uncommitted synthesis edits accumulated across the prior HN-1 + web-search-1 + git-repo-1 runs); the 9 dirty files (`.last-update.json` + `quickstart.md` + `sources/{README,hackernews,nocodb,ragflow,seafile,web-search,wikijs}.md`) are awaiting the next CLI commit cycle |
|
||||
| **Operational issue carried over from prior runs** | n/a | **`2507925` 2026-08-15 sources-sync bug** + the 2026-08-16 `997b648` + 2026-08-17 `be49285` sources-syncs (which re-applied the same operational pattern as `2507925` — NocoDB / Wiki.js / RAGFlow count values stayed zero across all 3 sources-syncs). The on-disk `~/.openwiki/connectors/web-search/config.json` is unaffected — this is a wiki-side CRON issue with the auto-source-sync job, not a connector config issue. Recorded for traceability on `/sources/git-repo.md` Notable-entity § "2026-08-15 sources-sync bug" and on each affected `/sources/{nocodb,ragflow,seafile,wikijs}.md` page. The data is recoverable from `git show 8ddc6d9:sources/nocodb.md` etc. for any future recovery commit |
|
||||
|
||||
## Vault navigation index
|
||||
|
||||
@@ -357,7 +472,7 @@ Markdown file counts per deep-read subfolder:
|
||||
|
||||
| Subfolder | .md count |
|
||||
| --- | --- |
|
||||
| `Organoid/` | 659 |
|
||||
| `Organoid/` | 661 (+2 from 2026-08-16 — Quintard 2024 Nat Commun microfluidic vascularized organoid chip + Guo 2026 Front Cell Dev Biol organoid ethics systematic review) |
|
||||
| `Celvivo/` | 142 |
|
||||
| `3Brain/` | 136 |
|
||||
| `Cellink/` | 129 |
|
||||
@@ -376,13 +491,13 @@ Markdown file counts per deep-read subfolder:
|
||||
| `Microbioreactor/` | 1 (new as of 2026-08-07 — Rosero 2026 Front Bioeng Biotechnol) |
|
||||
| `Cells/` | 1 (new as of 2026-08-08 — Fernandez Vallone 2026 Cells THSDC) |
|
||||
| `Review/` | 1 (new as of 2026-08-13 — Zhou 2023 computer vision + microfluidics, **untracked**) |
|
||||
| `templates/` | 1 (new as of 2026-08-17 — `类器官IRB申请清单.md`, derived from the Guo 2026 ethics deep-read; Robin's first customer-facing template produced from a single deep-read, **untracked**) |
|
||||
| `celvivo_commercial/` | 1 (new as of 2026-08-17 — `1331651_20260630_131201.pdf`, the 6-30 quote PDF migrated into a new folder, **untracked**) |
|
||||
|
||||
Total ≈ 1,205 deep-read notes (+1 from the 2026-08-13 cluster:
|
||||
Total ≈ 1,207 deep-read notes on `main` (+2 from the 2026-08-16 Quintard 2024 + Guo 2026 clusters).
|
||||
Review/ zhou2023 computer vision + microfluidics, **untracked** — only
|
||||
counts once committed). The 2026-08-07 / 2026-08-08 cluster (Microbioreactor
|
||||
+ Cells) remains the most recent committed deep-read additions. CelVivo,
|
||||
3Brain, Cellink, and the broad `Organoid/` bucket cover Robin's product
|
||||
KB per the wiki goal focus areas (类器官培养与设备, 3D 生物打印).
|
||||
counts once committed; +2 working-tree files in the new `templates/` +
|
||||
`celvivo_commercial/` directories, both untracked). The 2026-08-16 Quintard 2024 + Guo 2026 cluster is the most recent committed deep-read additions; the 2026-08-07 / 2026-08-08 cluster (Microbioreactor + Cells) remains the prior committed cluster. CelVivo, 3Brain, Cellink, and the broad `Organoid/` bucket cover Robin's product KB per the wiki goal focus areas (类器官培养与设备, 3D 生物打印). The new `templates/` folder signals Robin may be formalizing customer-facing deliverables (checklists / templates / sales scripts) as a separate vault subtree — the IRB application checklist is the first such artifact.
|
||||
|
||||
## Distributor map refresh (2026-08-07)
|
||||
|
||||
@@ -443,7 +558,11 @@ fields still 待补).
|
||||
|
||||
## Notable entities surfaced by the vault (structural hints only)
|
||||
|
||||
- **Review/ subfolder — first entry (2026-08-13, still uncommitted at 2026-08-15)** — `obsidian-vault/04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md` is the **first file in a new `Review/` subfolder** under `04-Literature/Deep-Reads/`. The file is **untracked** at the 2026-08-15 fetch (Robin has not yet committed it — same state as the 2026-08-13 fetch, 0 progress in the 2026-08-13 → 2026-08-15 24-hour window), so the synthesis is provisional, but the path naming convention (`zhou2023_computer_vision_microfluidics.md`) matches Robin's standard deep-read naming pattern (`author-year-keyword-keyword.md`). Likely content: Zhou et al. (2023) computer-vision + microfluidics cross-review paper — a **review-type** paper (rather than an original-research paper) that Robin is collecting as part of his broader organoid + microfluidic cross-anchor reading list. **Structural significance**: the `Review/` subfolder is new — none of the existing 19 subfolders (`Organoid/`, `Celvivo/`, `3Brain/`, `Cellink/`, `Organoid-List/`, `Product-Reports/`, `Brain/`, `Brain-Tumor/`, `Cancer/`, `Liver/`, `Other/`, `RegenMed/`, `3Brain MEA/`, `Cardiac/`, `Kidney/`, `Retinal/`, `Microbioreactor/`, `Cells/`) explicitly segregates review-type papers. A `Review/` subfolder signals Robin may be formalizing the review-paper stream separately from the original-research stream. **No synthesis routes** until the file is committed — the deep-read synthesis page + any vendor-mapping should land after Robin commits the file and the standard 8-step LDR pipeline publishes it to Wiki.js / NocoDB / SeaFile. Track on the next git-repo fetch whether (a) the file is committed, (b) the `Review/` subfolder accumulates additional entries, and (c) the standard page-946 9 项 SOP + page-934 修齐 alignment is applied. **Carry-forward status** (2026-08-13 → 2026-08-15): unchanged. The `Review/` subfolder is still single-entry, still untracked, no follow-up paper landed in this subfolder in the 48-hour window since the first observation. Watchlist trigger: if the file remains uncommitted at the next fetch (2026-08-17 or later), the structural signal weakens (single-entry subfolder could be a one-off rather than a recurring pattern).
|
||||
- **Quintard 2024 Nat Commun microfluidic vascularized organoid chip (2026-08-16, 7 commits in 48-hour window)** — `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` (189 lines; 4-commit LDR cycle `0fc8db24` adds → `290e9635` -v2 修图床/双 H1/落款 → `24c713de` -v3 Wiki.js 自带图床 6 张图 → `4073abf4` -v4 转发语标题/落款加粗/删 3Brain; Wiki IDs 1719/1720/1722, NocoDB Id 3297). The paper is **the first microfluidic / organ-on-chip platform paper** Robin has deep-read in the 2026-08 window; the platform combines (i) 10-channel parallel microfluidic chips with U-shaped capture sites (300-800 µm adjustable), (ii) fibrin + Matrigel hydrogel layer deposition using Landau-Levich-Bretherton effect, (iii) ~10 s capture efficiency ~100%, (iv) dynamic perfusion 7-30 days with HUVEC + fibroblast co-culture + hiPSC-derived BVO + islet spheroid + lung organoid cross-validation, (v) hierarchical vasculature (37 µm upstream artery-vein + 8 µm BVO capillaries, matching physiological ranges 50-1900 s⁻¹). **Net-new external evidence** in this run (git-repo-1 2026-08-17). The 4-star "与我们的产品" table lists **Mimetas OrganoPlate ⭐⭐⭐⭐** (direct Phaseguide-based vascularized / kidney / intestine organ-on-chip competitor) + **CelVivo ClinoStar ⭐⭐⭐** (upstream workflow step: BVO differentiation day 0-15 needs rotating-wall suspension culture; ClinoStar is the canonical hardware for this stage; the paper's day 15 → chip-on-board handoff is the canonical CelVivo → organ-on-chip workflow) + **Emulate Organ-Chip ⭐⭐⭐** (Colon-Intestine-Liver platform companion). Synthesis routes into `/themes/05-robin-research.md` (新增 by-vendor entry) and `/sources/literature.md` (last-30-days deep-read table). Vendor-anchor mapping: CelVivo-adjacent (workflow upstream) + Mimetas OrganoPlate / Emulate Organ-Chip (organ-on-chip product lane that Robin's portfolio does not currently cover but represents a potential cross-sell if Robin's customers ask "where do I run my CelVivo-matured organoids in a vascularized microenvironment?"). Customer-entry: 药企临床前 (vascularized drug screening) + 微流控 organ-on-chip 平台集成商 (Mimetas / Emulate channel partners) + academic PI (vascular development / diabetes). **Track on next fetch** whether Robin publishes a `/sources/literature-quintard-2024-nat-commun-vasorganoid-chip-deepread.md` synthesis page; the deep-read pipeline currently only carries `liang-2026-celvivo-clinostar-positioning` + `miao-2025-celvivo-clinostar-positioning` + `liu-2026-hd-mea-roadmap-implication` + `sharma-2026-retinal-organoid-mea-cross-sell` — no Quintard synthesis page yet.
|
||||
- **Guo 2026 Front Cell Dev Biol organoid ethics systematic review (2026-08-16, 7 commits in 48-hour window)** — `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` (170 lines + 3 真图; 3-commit LDR cycle `2e6f5989` adds → `00f824f2` -v2 修图床 (加 2 张 Wiki.js 自带图) → `a4fa5a32` -v3 补 Fig 1; Wiki ID 1724, NocoDB Id 3298). The paper is **the first organoid-research ethics / IRB systematic review** Robin has deep-read in any window — fills the methodological gap on the IRB-side that the prior clinical-translation evidence (CDE classification + Order No. 818) does not directly cover. The paper structures the IRB review framework as **7 mandatory points** (sample provenance + donor informed consent + data privacy & de-identification + co-culture agency + animal welfare 3R + cross-border regulation + long-term storage & termination); the cross-border table compares China (《人类遗传资源管理条例》+ 《涉及人的生命科学和医学研究伦理审查办法》2023), US (HIPAA + Common Rule + NIH GDS), EU (GDPR + Clinical Trials Regulation 536/2014), Japan, Korea. The 4-star "与我们的产品" table lists **CelVivo ClinoStar ⭐⭐⭐⭐** (clinical-translation IRB compliance — the 7 mandatory points directly apply to ClinoStar customer IRB submissions; **Robin 推广 ClinoStar 给三甲医院时, 可附带本框架作为增值**) + **Mimetas OrganoPlate ⭐⭐⭐⭐** (co-culture ethics — Mimetas 主营类器官 + 免疫细胞共培养, the co-culture agency framework from Guo 2026 point 4 directly applies) + **Emulate Organ-Chip ⭐⭐⭐** (organoid + microfluidic cross-border regulation reference). **Net-new external evidence** in this run (git-repo-1 2026-08-17). Robin translated the paper into a **customer-facing sales ammunition template** at `templates/类器官IRB申请清单.md` (180 lines; 7 mandatory points checklist + 5 customer Q&A + China vs International flow table + 10 attachments + 7 citations; v1.0 dated 2026-08-16, "Robin 8-16 实战沉淀") — see the templates/ entry in the next bullet. Customer-entry: 临床转化型医院 (class A tertiary hospitals running organoid IRB submissions) + 类器官厂家 Robin 培训客户 (the IRB checklist is the canonical "Robin 培训客户 IRB 申请" core material) + academic PI (cross-border collaboration IRB paperwork). **Track on next fetch** whether (a) the templates/ IRB checklist gets committed, (b) the Robin-author attribution in the template is recognized as a wiki-side customer-training artifact, (c) Robin produces a deep-read synthesis page at `/sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md`, and (d) the IRB checklist routes into the existing CelVivo industrial-customers program (which currently lives at `05-Documents/Products/Celvivo/Industrial-Customers/`) as a standard customer-training artifact.
|
||||
- **Review/ subfolder — first entry (2026-08-13, still uncommitted at 2026-08-17, 4-day carry-forward, watchlist signal weakening)** — `obsidian-vault/04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md` is the **first file in a new `Review/` subfolder** under `04-Literature/Deep-Reads/`. The file is **untracked** at the 2026-08-17 fetch (Robin has not yet committed it — same state as the 2026-08-13 + 2026-08-15 fetches, 0 progress in the 2026-08-13 → 2026-08-17 96-hour window). **Watchlist trigger met at this fetch**: per the 2026-08-15 watchlist-trigger rubric ("if the file remains uncommitted at the next fetch (2026-08-17 or later), the structural signal weakens"), the `Review/` subfolder at the 2026-08-17 fetch is **still single-entry, still untracked** — the structural signal **does weaken** at this fetch (4-day carry-forward with no commit, no follow-up paper landed in the subfolder). The `Review/` subfolder is more likely to be a one-off than a recurring pattern. The file should either be committed on a future fetch (which would re-strengthen the signal) or remain untracked indefinitely (which would confirm the one-off interpretation). No synthesis routes until the file is committed.
|
||||
- **`templates/` subfolder — first entry (2026-08-16, NEW this run)** — `templates/类器官IRB申请清单.md` (180 lines, mtime 2026-08-16, untracked) is the **first file in a new `templates/` directory** at the vault root. The file is Robin's **first customer-facing sales ammunition template produced from a single deep-read** (the Guo 2026 IRB ethics systematic review). Content: 7 mandatory IRB review points checklist (样本来源/知情同意/数据隐私/共培养主体性/3R 动物福利/跨境监管/长期保存与终止使用) + 5 customer Q&A ("类器官研究要不要 IRB 申请?" / "类器官共培养产品怎么申请 IRB?" / "类器官跨境研究怎么报?" / "3R 原则怎么写?" / "类器官 + 免疫细胞共培养 = CAR-T 体外培养, 算不算新生物体? 伦理上算什么?") + China vs International flow comparison table + 10-row 申请附件清单 + 7 references (Guo 2026 + ISSCR 2021 + OHRP 2016 + GDPR 2018 + China 2023 + China 2019 + Cambridge 2020). The template's `version: v1.0 (2026-08-16, Robin 8-16 实战沉淀)` and `Robin 业务定位: 类器官厂家给三甲医院 IRB 申请的标准模板 + Robin 客户培训材料核心` framing makes it explicit that this is the canonical "Robin 培训客户 IRB 申请" core material. **Structural significance**: the `templates/` directory is new — none of the existing top-level folders (`01-Active-Sales/` / `02-Clients/` / `02-Active-Deals/` / `02-Contacts/` / `03-Product/` / `03-Resources/` / `04-Literature/` / `05-Documents/` / `06-Sales/` / `99-Templates/` / `memory/`) provides a vendor-agnostic customer-training-artifact slot at the vault root. The Obsidian vault already has `99-Templates/` for reusable Obsidian templates (note templates, daily-report templates — per `99-Templates/` size hint 14 .md), but the new `templates/` directory is **for customer-facing sales ammunition**, not Obsidian note templates — a different artifact type. The naming convention overlaps with `99-Templates/` and may need disambiguation; Robin's intent (per the file header) is for this `templates/` to be the **canonical customer-training artifact directory**, distinct from `99-Templates/` Obsidian-note templates. **Customer-entry scenarios** called out in the template: (a) 类器官厂家研发负责人 = IRB 申请准备, (b) Robin 客户开发 = 培训客户 IRB 申请核心材料, (c) 医院 IRB 委员会 = 类器官研究 IRB 审查标准参考, (d) 学术合作方 = 跨境合作时多国法规差异对照. **Carry-forward status** (2026-08-17): untracked, future-commit candidate. **Track on next fetch** whether (a) Robin commits the file to `main`, (b) more templates land in the directory (extending the customer-training-artifact slot), (c) the `templates/` and `99-Templates/` naming overlap gets resolved (rename / docs / conventions). Synthesis routes into `/themes/05-robin-research.md` (sales ammunition pipeline section).
|
||||
- **`celvivo_commercial/` subfolder — first entry (2026-08-17, NEW this run)** — `celvivo_commercial/1331651_20260630_131201.pdf` (56 KB PDF, mtime 2026-08-17, untracked) is the **first file in a new `celvivo_commercial/` directory** at the vault root. The PDF is the existing 6-30 quote PDF that Robin migrated into a new folder. The file is **a quote PDF**, not a synthesis target — the on-disk evidence is the existing 6-30 quote document that already exists in `05-Documents/Products/Celvivo/Industrial-Customers/` (per the 2026-08-15 synthesis-policy section above, "commercial docs (8 files: Exhibit 1 Price Book / Exhibit 3 SuperUser certification / Huibai demo discount agreement / 惠百 PO 盖章版 / Celvivo Distribution Agreement 2026 Huibai Bio / 1331651_20260630_131201 (6-30 quote) / Packing Slip Ordre 726_1 / Packing Slip Ordre 726_2)"). **Structural significance**: the `celvivo_commercial/` directory is new — Robin has migrated the 6-30 quote out of wherever it was previously (presumably a working folder or `05-Documents/Products/Celvivo/` deep path) into a top-level dedicated directory. **The migration is unfinished** — only 1 file in the new directory; if Robin intends the directory to consolidate all 8 commercial docs from `05-Documents/Products/Celvivo/Industrial-Customers/`, the other 7 files (Exhibit 1 Price Book / Exhibit 3 SuperUser certification / Huibai demo discount agreement / 惠百 PO 盖章版 / Celvivo Distribution Agreement 2026 / Packing Slip Ordre 726_1 / Packing Slip Ordre 726_2) should eventually land here too. **No synthesis routes** until Robin commits the file or migrates more docs into the directory. Carry-forward status (2026-08-17): untracked, single-entry, future-commit candidate. Track on next fetch whether (a) the file gets committed, (b) more commercial docs migrate into the directory.
|
||||
- **2026-08-15 sources-sync bug — count-data wipe (operational)** — the `2507925e27b83b4f9d2e6f3b9c939d081a90f9f2` `chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-15)` commit at 2026-08-15 +0800 02:31 committed **empty count values** for NocoDB / Wiki.js / RAGFlow (SeaFile was already empty so the commit was a no-op there): (a) NocoDB: 6614 → **0** total records, with all 13 per-table counts (brain_organoid_literature / intestinal_organoid_literature / Celvivo_literature / cardiac_organoid_literature / cancer_organoid_literature / liver_organoid_literature / other_organoid_literature / kidney_organoid_literature / retinal_organoid_literature / Cellink_literature / organoid_literature_old / lung_organoid_literature / 3Brain_literature) cleared to empty cells; (b) SeaFile: libraries table unchanged (was empty in `1737454` already — a separate, older cron issue not introduced by `2507925`); (c) Wiki.js: 83 → **0** unique pages, ID range 22..1704 → **0..0**, Locale 分布 → empty, Top-level 路径分布 → empty; (d) RAGFlow: landing 200 → **000**, `/api/v1/health` 404 → **000**, `/api/v1/datasets` 401 → **000**. The header lines on each affected `/sources/{nocodb,ragflow,seafile,wikijs}.md` page still report `上次同步: 2026-08-14T18:30:42Z` (the prior successful sync timestamp), but the body count values are wiped. **Probable root cause**: the auto-source-sync CRON job ran but the underlying NocoDB / Wiki.js / RAGFlow API calls failed (likely the same operational issue already documented on `/sources/web-search.md` and `/sources/README.md` — runtime registry disagreement on `enabled: true` vs. disabled); the script committed the empty values instead of skipping the commit on failure. **Impact**: 3 source pages now show misleading zero/null values (NocoDB / Wiki.js / RAGFlow); Tavily / HN / git-repo synthesis is unaffected. **Recovery**: the wiped data is recoverable from the prior wiki commit (`git show 1737454:sources/nocodb.md` etc. will restore the pre-wipe state). This run restored the wiped data on all 3 affected pages (plus an operational note documenting the bug) so the wiki is internally consistent again. **Wiki-synthesis concern**: **none** — the synthesis layer (themes / commitments / open-questions / personal-logistics) is independent of the source-page counters. **Operational concern**: **yes** — the auto-source-sync job should (a) check connectivity before committing, (b) skip the commit on API failure rather than committing empty values, or (c) preserve the prior counter values when a fresh pull returns null/empty. Recorded for traceability here + on each affected `/sources/{nocodb,ragflow,seafile,wikijs}.md` page.
|
||||
- **Liang 2026 liver organoid fibrosis platform (2026-08-12)** — `04-Literature/Deep-Reads/Liver/2026-08-12_Liang_2026_SciRep_liver_organoid_fibrosis_platform.md` (170 lines; `[[MOC-类器官与3D培养]]` already names this paper via `related:` back-link). The paper is **the net-new external evidence** this run (git-repo-1 2026-08-12) brought into the vault; see synthesis at `/themes/01-organoid-equipment.md` § CelVivo evidence (added 2026-08-12) and `/commitments.md` `liang-2026-celvivo-clinostar-positioning`. Single-paper LDR cycle: 4 commits (`e542c977` → `8699a154` → `aacba7aa` → `297f106d`) walked Robin's standard 3-stage SOP on the same file (186 lines → 105+/122- page 946 rewrite → page 934 修齐 micro-revisions). The 4-star "与我们的产品" table on the paper lists **CelVivo ClinoStar ⭐⭐⭐⭐** (P1-P10 长程扩增对应旋转培养 30+ 天无剪切; HSC 静止态在模拟微重力下 7+ 天维持) + **CelVivo ClinoReactor ⭐⭐⭐⭐** (单组织 3 轨道分通道灌流; TGFβ 时间程序精确切换) — **parallel CelVivo ClinoStar rating 5 to Miao 2025 v2's ClinoStar rating 5** from the 2026-08-08 flywheel-sync, but for liver organoid (long-term maturation + fibrosis modeling) rather than lung organoid (vascularization). 7 SeaFile Fig (Fig1-7) + 4-paper 参考文献 (Huch 2013 / Huch 2015 / Clevers 2016). Customer-entry: 药企临床前 (抗纤维化药筛) + 临床肝活检中心 (1-2 mg → 3 周药敏) + 学术 PI (2D vs 3D 旋转 efficiency). **MOC linkage**: the paper's `related:` field already names `[[MOC-类器官与3D培养]]` (the first MOC, created 2026-08-10) — confirming the MOC pattern is in active use on real deep-reads.
|
||||
- **CelVivo industrial customers program** — a dedicated subfolder under
|
||||
@@ -526,15 +645,118 @@ fields still 待补).
|
||||
|
||||
## Synthesis policy for this source
|
||||
|
||||
- **This run (2026-08-15, git-repo-1 18:07Z):** **0 new vault commits**
|
||||
in the 2026-08-13T18:08Z → 2026-08-15T18:07Z window — the vault HEAD
|
||||
is unchanged at `297f106d` across **both** the 2026-08-13 and
|
||||
2026-08-15 fetches (the 2026-08-12 Liang 2026 4-commit LDR cluster
|
||||
remains the most recent vault activity). **No new untracked files**
|
||||
in the 24-hour window — the untracked file set is unchanged from
|
||||
the 2026-08-13 fetch (the `Review/zhou2023_computer_vision_microfluidics.md`
|
||||
first-entry-in-Review/-subfolder is still untracked, carrying
|
||||
forward). Wiki-side: **4 new wiki commits** landed (`021e929` daily
|
||||
- **This run (2026-08-17, git-repo-1 18:09Z):** **7 new vault commits**
|
||||
landed in the 2026-08-15T18:07Z → 2026-08-17T18:09Z window — the vault
|
||||
HEAD bumped from `297f106d` (the 2026-08-12 Liang 2026 cluster) to
|
||||
`a4fa5a32` (the 2026-08-16 Quintard 2024 + Guo 2026 cluster). The
|
||||
cluster breaks down as: (a) **Quintard 2024 Nat Commun 4-commit LDR
|
||||
cycle** (`0fc8db24` adds 189 lines → `290e9635` -v2 修图床/双 H1/落款
|
||||
→ `24c713de` -v3 Wiki.js 自带图床 6 张图 → `4073abf4` -v4 转发语标题/
|
||||
落款加粗/删 3Brain) on `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md`;
|
||||
(b) **Guo 2026 Front Cell Dev Biol 3-commit LDR cycle** (`2e6f5989`
|
||||
adds 170 lines → `00f824f2` -v2 修图床 (加 2 张 Wiki.js 自带图) →
|
||||
`a4fa5a32` -v3 补 Fig 1) on
|
||||
`obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md`.
|
||||
The 2026-08-16 cluster is **the first time since the 2026-07-28 /
|
||||
2026-07-29 Parate / Lee / Hodge cluster** that two new paper deep-reads
|
||||
landed on `main` in the same 48-hour window, and **the first time a
|
||||
review-type IRB / ethics systematic review (Guo 2026) was deep-read**
|
||||
in any vault window. **2 new untracked directories** appeared in
|
||||
the working tree this fetch: (a) `celvivo_commercial/1331651_20260630_131201.pdf`
|
||||
(the 6-30 quote PDF migrated into a new folder); (b) `templates/类器官IRB申请清单.md`
|
||||
(the IRB application checklist Robin produced from the Guo 2026
|
||||
review — Robin's **first customer-facing sales ammunition template**
|
||||
derived from a single deep-read). The 23 untracked working-tree
|
||||
files from the 2026-08-13 fetch are unchanged at this fetch (the
|
||||
`Review/zhou2023_computer_vision_microfluidics.md` first-entry-in-Review/-subfolder
|
||||
is still untracked, now a **4-day carry-forward** with watchlist
|
||||
signal weakening per the Notable-entity entry). Wiki-side: **4 new
|
||||
wiki commits** landed (`151d22b` daily update 2026-08-16 +
|
||||
`997b648` sources-sync 2026-08-16 + `5c70881` daily update 2026-08-17
|
||||
(created the new `sources/openwiki-version-drift.md` auto-generated
|
||||
page) + `be49285` sources-sync 2026-08-17), advancing HEAD from
|
||||
`2507925` (2026-08-15) to `be49285` (2026-08-17). 9 dirty wiki files
|
||||
in the working tree (`.last-update.json` + `quickstart.md` +
|
||||
`sources/README.md` + `sources/hackernews.md` + `sources/nocodb.md`
|
||||
+ `sources/ragflow.md` + `sources/seafile.md` + `sources/web-search.md`
|
||||
+ `sources/wikijs.md`) are **accumulated** synthesis-layer edits
|
||||
from the prior HN-1 2026-08-15 + HN-1 2026-08-16 + HN-1 2026-08-17 +
|
||||
web-search-1 2026-08-15 + web-search-1 2026-08-17 + git-repo-1
|
||||
2026-08-15 runs that are pending the next CLI orchestration commit
|
||||
(down from 10 dirty files at the 2026-08-15 fetch — `sources/index.md`
|
||||
got committed in the `151d22b` 2026-08-16 daily update). One
|
||||
**new wiki file** added in the window: `sources/openwiki-version-drift.md`
|
||||
(auto-generated OpenWiki version drift monitor; reports `v0.3.1` local
|
||||
→ `v0.3.3` npm latest as of 2026-08-15T20:00:03Z with a manual
|
||||
`npm install -g openwiki@latest` action and a WARNING that v0.3.1 →
|
||||
v0.4+ may have breaking changes; the page is informational, not a
|
||||
synthesis target). **No `/commitments.md` row, no
|
||||
`/open-questions.md` row, no `/personal-logistics.md` item**
|
||||
added this run beyond the canonical synthesis pipeline — the
|
||||
Quintard 2024 deep-read has no existing synthesis page yet (the
|
||||
deep-read pipeline currently only carries `liang-2026-celvivo-clinostar-positioning`
|
||||
+ `miao-2025-celvivo-clinostar-positioning` + `liu-2026-hd-mea-roadmap-implication`
|
||||
+ `sharma-2026-retinal-organoid-mea-cross-sell`); the Guo 2026 IRB
|
||||
review is the first ethics-side deep-read and the IRB checklist
|
||||
template is the first customer-facing sales ammunition template,
|
||||
both of which warrant a commitment + a synthesis page on a future
|
||||
fetch. Wiki edits this run: (a) `/sources/git-repo.md` (this page)
|
||||
— refreshed frontmatter HEAD pointers (vault HEAD `297f106d` →
|
||||
`a4fa5a32`, wiki HEAD `2507925` → `be49285`, tags + `2026-08-17`,
|
||||
timestamp → `2026-08-17T18:09:32Z`), refreshed the Connector / State
|
||||
section to the new `2026-08-17T18-09-32-895Z` raw manifest, refreshed
|
||||
the obsidian-vault working-tree-status section to 2026-08-17 (7 new
|
||||
vault commits, 2 new untracked dirs, the `Review/zhou2023_computer_vision_microfluidics.md`
|
||||
carries forward as still-untracked), refreshed the
|
||||
Recent-commits-for-vault table to put the 7 new 2026-08-16 commits
|
||||
on top of the 2026-08-12 cluster, refreshed the openwiki-wiki
|
||||
working-tree-status section to 2026-08-17 (4 new wiki commits + 9
|
||||
uncommitted synthesis-layer edits — `sources/index.md` got committed
|
||||
in `151d22b`), refreshed the Recent-commits-for-wiki table to put
|
||||
the 4 new 2026-08-16/2026-08-17 commits on top of the 2026-08-15
|
||||
cluster, refreshed the Summary-of-last-48-hours table to add the
|
||||
2026-08-15T18:07Z → 2026-08-17T18:09Z window data (7 vault commits /
|
||||
4 wiki commits / 9 uncommitted wiki files / 1 new wiki file +
|
||||
2 new untracked dirs + 4-day carry-forward on `Review/` subfolder),
|
||||
refreshed the Notable-entity section to add (a) "Quintard 2024
|
||||
microfluidic vascularized organoid chip" entry (with 4-star
|
||||
Mimetas/CelVivo/Emulate mapping), (b) "Guo 2026 organoid ethics
|
||||
systematic review" entry (with 4-star Mimetas/CelVivo/Emulate
|
||||
mapping + IRB checklist template cross-link), (c) refreshed
|
||||
"Review/ subfolder" entry with watchlist-trigger-met note, (d)
|
||||
new "templates/ subfolder" entry (first customer-facing sales
|
||||
ammunition template), (e) new "celvivo_commercial/ subfolder" entry
|
||||
(the 6-30 quote PDF migration), refreshed the Synthesis-policy
|
||||
section with this run's delta summary. **No `/themes.md` row change**
|
||||
— the new external evidence routes into the existing
|
||||
`class-organoid-3d-bioprinting` theme row (Quintard 2024 is
|
||||
organ-on-chip adjacent to Robin's 4 application domains; Guo 2026
|
||||
is IRB-side adjacent to the same row); the Robin-authored
|
||||
IRB checklist template routes into the existing
|
||||
`/themes/05-robin-research.md` "Sales ammunition pipeline" section
|
||||
rather than a new theme row. **No `/open-questions.md` row, no
|
||||
`/personal-logistics.md` item** — the IRB checklist is a
|
||||
vendor-anchored customer-training artifact, not a memory-graph
|
||||
uncertainty. (b) `/themes/05-robin-research.md` — vault-snapshot
|
||||
metadata refreshed (fetch timestamp → `2026-08-17T18:09:32Z`,
|
||||
raw-manifest path → the new `2026-08-17T18-09-32-895Z` manifest;
|
||||
vault HEAD `297f106d` → `a4fa5a32`; untracked-dir set refreshed
|
||||
with `celvivo_commercial/` + `templates/` entries; `04-Literature/Deep-Reads/Organoid/`
|
||||
count `659` → `661` (Quintard + Guo); 30-day research output
|
||||
table extended with the 2026-08-16 Quintard 2024 + Guo 2026 row;
|
||||
by-vendor table extended with `Microfluidic / organ-on-chip
|
||||
adjacent` and `Ethics / IRB` rows; Sales ammunition pipeline section
|
||||
extended with the `templates/类器官IRB申请清单.md` IRB checklist
|
||||
template). (c) `/themes/01-organoid-equipment.md` — Quintard 2024
|
||||
added to CelVivo evidence anchors (CelVivo ClinoStar rating 3
|
||||
upstream workflow step) and Guo 2026 added to the Regulatory /
|
||||
China-specific context section (CelVivo ClinoStar rating 4 IRB
|
||||
compliance ammunition; companion to the existing CDE classification
|
||||
+ Order No. 818 items). (d) `/sources/literature.md` — Quintard 2024
|
||||
+ Guo 2026 added to the 30-day deep-read index. (e) `/sources/README.md`
|
||||
— git-repo last-updated refreshed from `2026-08-15 18:07 UTC` to
|
||||
`2026-08-17 18:09 UTC`. (f) `/quickstart.md` — added the
|
||||
"Latest update — git-repo-1 (2026-08-17T18:09Z)" paragraph. Wiki-side: **4 new wiki commits** landed (`021e929` daily
|
||||
update 2026-08-14 + `6258717` sources-sync 2026-08-14 + `173b58c`
|
||||
daily update 2026-08-15 + `2507925` sources-sync 2026-08-15),
|
||||
advancing HEAD from `1737454` (2026-08-13) to `2507925` (2026-08-15).
|
||||
|
||||
+36
-4
@@ -2,7 +2,7 @@
|
||||
type: "Reference"
|
||||
title: "Hacker News — evidence index"
|
||||
description: "Compact evidence trail for the Hacker News connector (hackernews-1, Robin-curated life-sciences + AI workflow). Synthesis lives on /themes.md, /commitments.md, etc.; this page only records ingestion coverage and notable items."
|
||||
tags: [hackernews, evidence-index, source, 2026-08-16, 2026-08-15, 2026-08-13, 2026-08-12, 2026-08-10]
|
||||
tags: [hackernews, evidence-index, source, 2026-08-17, 2026-08-16, 2026-08-15, 2026-08-13, 2026-08-12, 2026-08-10]
|
||||
---
|
||||
|
||||
# Hacker News — evidence index
|
||||
@@ -15,10 +15,42 @@ Compact evidence trail for the Hacker News connector (`hackernews-1`, Robin-cura
|
||||
- **Backend:** public HN feeds (`top`, `new`) + Algolia HN search queries
|
||||
- **Auth:** none — public feeds
|
||||
- **Window:** last 24 hours
|
||||
- **Latest fetch:** `2026-08-16T18:00:39Z` (LLM-agent topic set: `organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents` — 6 queries; the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories" is the active query set; prior 2026-08-15 18:00, 2026-08-13 18:00, 2026-08-12 18:00, 2026-08-10 18:00, 2026-08-08 18:00, 2026-08-08 03:15, 2026-08-07 12:29, 2026-08-03 18:00, 2026-08-02 18:00, 2026-08-01 18:00, 2026-07-31 18:00, 2026-07-30 18:00, 2026-07-29 18:00, 2026-07-28 18:00, 2026-07-27 18:00, 2026-07-26 18:16 and 18:00 pulls also documented below)
|
||||
- **Raw dumps:** `~/.openwiki/connectors/hackernews/raw/2026-08-16T18-00-02-618Z/hackernews-results.json` (current — fifth consecutive fully-zero Algolia lane pull since 2026-08-07; two adjacents worth flagging for traceability: `49316271` Anthropic multi-agent systems research + `49319814` Show HN shared-memory public AI, see 2026-08-16 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-15T18-00-02-001Z/hackernews-results.json` (prior — fourth consecutive fully-zero Algolia lane pull since 2026-08-07; one high-engagement Robin-stack-adjacent: `49309549` Auto-research with codex 232x Faster Kernel, see 2026-08-15 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-13T18-00-02-662Z/hackernews-results.json` (prior — one directly-relevant `agent-memory-architecture` evidence (MCP Memory using OKF), see 2026-08-13 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-12T18-00-01-956Z/hackernews-results.json` (prior — one new low-engagement organoid signal, see 2026-08-12 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-10T18-00-02-327Z/hackernews-results.json` (prior — no promotable hits, see 2026-08-10 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-08T18-00-01-989Z/hackernews-results.json` (prior — no promotable hits, see 2026-08-08 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-08T03-14-40-856Z/hackernews-results.json` (prior — no promotable hits, see 2026-08-08 03:15 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-07T12-29-44-173Z/hackernews-results.json` (prior — no promotable hits, see 2026-08-07 entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-03T18-00-02-766Z/hackernews-results.json` (earlier — material findings, see 2026-08-03 entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-02T18-00-02-278Z/hackernews-results.json` (empty) · `~/.openwiki/connectors/hackernews/raw/2026-08-01T18-00-02-274Z/hackernews-results.json` (empty) · `~/.openwiki/connectors/hackernews/raw/2026-07-31T18-00-02-519Z/hackernews-results.json` (empty) · `~/.openwiki/connectors/hackernews/raw/2026-07-30T18-00-02-784Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-29T18-00-02-667Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-28T18-00-02-178Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-27T18-00-02-615Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-26T18-16-06-805Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-26T18-00-02-441Z/hackernews-results.json`
|
||||
- **Latest fetch:** `2026-08-17T18:00:31Z` (LLM-agent topic set: `organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents` — 6 queries; the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories" is the active query set; prior 2026-08-16 18:00, 2026-08-15 18:00, 2026-08-13 18:00, 2026-08-12 18:00, 2026-08-10 18:00, 2026-08-08 18:00, 2026-08-08 03:15, 2026-08-07 12:29, 2026-08-03 18:00, 2026-08-02 18:00, 2026-08-01 18:00, 2026-07-31 18:00, 2026-07-30 18:00, 2026-07-29 18:00, 2026-07-28 18:00, 2026-07-27 18:00, 2026-07-26 18:16 and 18:00 pulls also documented below)
|
||||
- **Raw dumps:** `~/.openwiki/connectors/hackernews/raw/2026-08-17T18-00-01-808Z/hackernews-results.json` (current — sixth pull since 2026-08-07 to have either a fully-zero or fully-noise Algolia lane (organoid/3Brain/Cellink each returned nbHits=6 string-collision noise; CelVivo/openwiki/deepagents each returned nbHits=0); two adjacents worth flagging for traceability: `49323381` Stripe acquires OpenRouter for $7B+ + `49331423` AI-Generated Copilot "Autofix" Snowflake Jira security incident, see 2026-08-17 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-16T18-00-02-618Z/hackernews-results.json` (prior — fifth consecutive fully-zero Algolia lane pull since 2026-08-07; two adjacents worth flagging for traceability: `49316271` Anthropic multi-agent systems research + `49319814` Show HN shared-memory public AI, see 2026-08-16 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-15T18-00-02-001Z/hackernews-results.json` (prior — fourth consecutive fully-zero Algolia lane pull since 2026-08-07; one high-engagement Robin-stack-adjacent: `49309549` Auto-research with codex 232x Faster Kernel, see 2026-08-15 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-13T18-00-02-662Z/hackernews-results.json` (prior — one directly-relevant `agent-memory-architecture` evidence (MCP Memory using OKF), see 2026-08-13 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-12T18-00-01-956Z/hackernews-results.json` (prior — one new low-engagement organoid signal, see 2026-08-12 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-10T18-00-02-327Z/hackernews-results.json` (prior — no promotable hits, see 2026-08-10 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-08T18-00-01-989Z/hackernews-results.json` (prior — no promotable hits, see 2026-08-08 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-08T03-14-40-856Z/hackernews-results.json` (prior — no promotable hits, see 2026-08-08 03:15 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-07T12-29-44-173Z/hackernews-results.json` (prior — no promotable hits, see 2026-08-07 entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-03T18-00-02-766Z/hackernews-results.json` (earlier — material findings, see 2026-08-03 entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-02T18-00-02-278Z/hackernews-results.json` (empty) · `~/.openwiki/connectors/hackernews/raw/2026-08-01T18-00-02-274Z/hackernews-results.json` (empty) · `~/.openwiki/connectors/hackernews/raw/2026-07-31T18-00-02-519Z/hackernews-results.json` (empty) · `~/.openwiki/connectors/hackernews/raw/2026-07-30T18-00-02-784Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-29T18-00-02-667Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-28T18-00-02-178Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-27T18-00-02-615Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-26T18-16-06-805Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-26T18-00-02-441Z/hackernews-results.json`
|
||||
|
||||
## Latest update — 2026-08-16 18:00 UTC
|
||||
## Latest update — 2026-08-17 18:00 UTC
|
||||
|
||||
- **Coverage:** 2 feeds (`top`, `best`), 6 search queries (the same simplified LLM-agent topic set from the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories": `organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents`). `top` feed returned 26 items, `best` feed returned 17; deduplication gave **34 unique items across both feeds** (9 overlap: `49324985` Qwen 3.8 27B, `49324087` Anthropic Claude watermarks, `49330781` DuckDB v2.0, `49326816` Linear algebra, `49325789` AI regulation, `49325061` Reticulum, `49329575` GPT 5.6 Sol, `49330597` GitHub incident, `49323686` Nvidia/OpenAI infra reduction). The 6-query lane produced the hit table below; the connector completed normally at `fetchedAt: 2026-08-17T18:00:31.353Z` (24-hour window).
|
||||
- **Life-science lane:** **zero vendor-anchored hits across all four named vendor queries — Algolia returned nbHits>0 only as string-collision noise.** The pattern matches the 2026-08-10 + 2026-08-12 pulls (noise-only on substring fragments) rather than the 2026-08-08 03:15 + 2026-08-08 18:00 + 2026-08-13 + 2026-08-15 + 2026-08-16 pulls (clean zero). Specifically: `organoid` returned `nbHits=6` — all string-collision noise on the "organi-" substring (`49333633` EFF organizations, `49333041` Google Maps "organic mode", `49331551` Saggar terminal "organized", `49331243` SaaS mockup "organization", `49328016` "organised" coding benchmark, `49327500` "organization" productivity essay). `CelVivo` returned `nbHits=0` (clean zero). `3Brain` returned `nbHits=6` — all string-collision noise on the "brain" / author-substring (`49331883` "Future of the Brain" 2005 video, `49331363` MIT "Flexible brain circuits can switch between different tasks" 2pts, `49329122` "brainless" author on Knowledge Graph article, `49328432` "brain protection" device article, `49327500` "brainbattler" productivity blog, `49327395` Columnary Chrome extension with "brain" in body). `Cellink` returned `nbHits=6` — all string-collision noise on substrings "calling"/"celine"/"ceiling"/"welling" (`49333633` EFF "calling", `49332326` Agent Mesh body-text "calling" — see flag-for-traceability note below, `49330671` Deepseek Harness Plugin author "celineycn", `49327308` "ceiling" in Ask HN, `49323983` "Wellington" bookstore, `49322618` tennis "calling"). `openwiki` returned `nbHits=0` (clean zero). `deepagents` returned `nbHits=0` (clean zero). A title/URL regex sweep across the 34 unique top+best items also turned up zero organoid / 3D-bioprinting / CelVivo / 3Brain / Cellink / ClinoStar / ClinoReactor / MEA / spheroid / organ-on-chip items. The "no material HN footprint for the 4 vendor lines" finding continues to hold — this is the **sixth pull since 2026-08-07 to have an empty / noise-only Algolia lane on vendor queries** (after the 2026-08-08 03:15 + 2026-08-08 18:00 + 2026-08-13 + 2026-08-15 + 2026-08-16 fully-zero pulls; the 2026-08-10 + 2026-08-12 pulls also returned noise-only on the substring queries). The Tavily web-search lane remains the better signal for vendor news.
|
||||
- **Workflow lane:** **zero positive `openwiki` brand hits; zero `deepagents` hits.** `openwiki` and `deepagents` both returned `nbHits=0` — so the `openwiki-brand` watchlist row on `/themes.md` stays at Last seen 2026-07-16 and the `agent-memory-architecture` adjacency note for "OpenWiki brand signal" stays at Last seen 2026-07-29. The 34 unique top+best items include **no directly-relevant item for any `/themes.md` row** but include **two adjacent items worth flagging for traceability** — plus several higher-engagement items that fall outside Robin's 4 application domains (3D cell culture, 3D bioprinting, neuroscience in vitro, organoid workflows) and the named-stack scope (Hermes / MiniMax / OpenWiki / RAGFlow / NocoDB / SeaFile / Codex CLI). The two adjacents stay adjacent-not-promoted under the brief's "low-engagement items are watchlist by default; promotion requires recurrence, strong engagement, or corroboration" rule **and** the `/themes.md` scope discipline:
|
||||
- **`49323381` "Stripe will reportedly acquire OpenRouter for $7B+"** (439 pts, 271 cmts, **best feed**, by `zacharyozer` 2026-08-16, https://techcrunch.com/2026/08/16/stripe-will-reportedly-acquire-ai-gateway-startup-openrouter-for-7b/). TechCrunch report on Stripe's reported $7B+ acquisition of OpenRouter, the AI model-routing gateway that aggregates DeepSeek / Qwen / Google / OpenAI / Anthropic / Mistral / Cohere / Perplexity / MiniMax-M3-adjacent models under one inference API. **Strongest single business event in the broader AI inference lane this pull** — the 439-pt + 271-cmt engagement makes it the highest-engagement business-side signal on this pull after the Qwen 3.8 27B Simon Willison blog (which is open-weight). Strong topical fit to the `MiniMax-m3` row's competitive-benchmarks lane (OpenRouter is a primary MiniMax-adjacent inference provider alongside the direct MiniMax-M3 HuggingFace + Tweet launch points), and to the AI-agent-inference supply chain that Robin's Hermes Agent stack sits in. **However** (a) Stripe acquiring OpenRouter is a **payment-processor + routing-gateway acquisition**, not a change to Hermes / MiniMax / OpenWiki / Codex CLI / RAGFlow / NocoDB / SeaFile directly; (b) the established scope rule on inference-provider business events keeps them adjacent-not-promoted unless there is a direct change to Hermes / MiniMax / OpenWiki / Codex CLI itself (per the 2026-07-30 / 2026-08-03 / 2026-08-10 / 2026-08-12 / 2026-08-13 / 2026-08-15 / 2026-08-16 traceability entries); (c) the established "open-weight AI never earns a `themes.md` row" scope rule would apply if OpenRouter were itself open-weight, but OpenRouter is a commercial gateway — the rubric remains "stay adjacent because not on Robin's named stack". **Adjacent-not-promoted** per scope. The 439-pt + 271-cmt engagement is high enough to surface in any HN digest even if the finding is not promoted. **No commitment row** — Robin does not currently use OpenRouter as a primary inference path (his Hermes Agent stack uses direct MiniMax API + unsloth/MiniMax-M3-GGUF local-LLM path documented on the `/themes.md` `MiniMax-m3` row); if a Hermes / MiniMax-side response to the Stripe-OpenRouter deal surfaces on a future pull (e.g. MiniMax changing its MiniMax-API pricing terms in response to the acquisition, or a Hermes v0.19 / v0.20 patch release noting OpenRouter as a supported inference path), this becomes the first corroborating event for an `MiniMax-m3-row-annex-inference-routing-changes` annex on the existing row.
|
||||
- **`49331423` "AI-Generated GitHub Copilot 'Autofix' Allowed Compromise of Snowflake's Jira"** (168 pts, 81 cmts, **top feed**, by `galnagli` 2026-08-17, https://www.wiz.io/blog/red-agent-snowflake-copilot-cicd-bug). Wiz research write-up on a **production security incident** in which an AI-generated code suggestion from GitHub Copilot's "Autofix" feature (the agentic self-fix tool inside GitHub Copilot) was allowed to merge into Snowflake's CI/CD pipeline and **compromised Snowflake's Jira instance**. The 168-pt + 81-cmt engagement is high enough to surface in any HN digest. **This is the strongest agent-supply-chain / agent-tool-use security incident** to surface on HN top since the 2026-07-30 pull's `49214468` "Managing AI Coding Costs at Scale" Databricks blog (290 pts best — adjacent-only, off-scope). Strong topical fit to Robin's broader Hermes Agent / Codex CLI / OpenWiki agent-tool-use lane — Hermes Agent v0.19 Quicksilver's live subagent feature performs tool-use calls to filesystem / shell / API tools with user-confirmation gates (per [`/themes/03-ai-agents.md`](/themes/03-ai-agents.md)), and the Copilot Autofix → Snowflake Jira incident is the **canonical 2026-08 working example** of agent-generated code reaching production with a security-bypass. **However** (a) this is a **GitHub Copilot incident**, not a Hermes Agent / MiniMax / OpenWiki / Codex CLI incident; (b) the established scope rule on non-named-stack agent-security incidents keeps them adjacent-not-promoted unless there is a direct incident at a vendor in Robin's named stack; (c) the brief's "Workflow tooling priority LOW — surface story-worthy changes only" rule does not promote this to a `/themes.md` row by itself, though it does match the established "watchlist on agent-supply-chain security signals" pattern. **Adjacent-not-promoted** per scope. The 168-pt + 81-cmt engagement is high enough to surface in any HN digest. **No commitment row** — Robin does not use GitHub Copilot Autofix on the named stack (Hermes Agent's tool-use gates + Codex CLI's command-confirmation flow are the two agent surfaces that handle tool-use safety; if Hermes v0.21 / v0.20 patch release adds an explicit AI-coding-cost-supply-chain audit hook in response to the broader Copilot Autofix incident, that becomes a future-promotable commitment on `/commitments.md`).
|
||||
- **`49332326` "Show HN: Agent Mesh – Shared memory for multi-Agent coordination"** (1 pt, top feed, by `balgeman` 2026-08-17, https://github.com/cbalgeman/agent-mesh). Show HN surfacing for a "Human + multi-Agent shared memory system" — uses **SQLite for Agent Mail** (Agent-to-Agent message bus keyed by request/response id), a **decision log** keyed on id (mirrors the Karpathy LLM Wiki pattern of structured IDs in code comments / plan docs), a **Workbench dashboard** (web UI for tracking logs), and a **Claude app + CODEX via `codex exec` agent-mesh bridge** with **all decision modifications requiring Human approval from the Workbench**. Architectural pattern fits the broader `agent-memory-architecture` theme at the macro level (shared memory + decision log + agent-coordination + human-approval gate) — same broad lane as the OKF / MCP Memory / Karpathy LLM Wiki / MinIO AIStor Memory / Exabase BEAM cluster. **However** (a) the implementation uses SQLite + ids + workbench dashboard rather than OKF frontmatter (no `okf_version: "0.1"` reference in the README), so it doesn't corroborate the existing row's OKF+memory schema pattern (the criterion that drove the 2026-08-13 MCP Memory / Google's OKF Last-seen refresh); (b) 1-pt engagement is too low for a theme-row Last-seen refresh per the established "Watchlist promotion requires recurrence, strong engagement, or corroboration" rule (1 pt is well below the 100+ pt threshold for high-engagement vendor releases and below the 46-pt MCP Memory refresh trigger); (c) the item was surfaced by the `Cellink` Algolia query as a string-collision noise hit on the word "calling" in body text — not because it relates to Cellink bioprinters. **Adjacent-not-promoted** per scope. The 1-pt engagement is too low to refresh `agent-memory-architecture` Last seen on the existing row, but the macro-pattern is worth flagging in case a future HN item at higher engagement combines Agent Mesh + OKF frontmatter (or if Agent Mesh itself adds OKF support in a future version). **No commitment row, no open-question row, no `/themes.md` refresh.**
|
||||
- **`49324985` "Qwen 3.8 27B is excellent, but it defaults to overthinking things"** (732 pts, 344 cmts, top+best feed, by `bilsbie`, https://simonwillison.net/2026/Aug/16/qwen-38-27b/). **Highest-engagement item of the pull.** Simon Willison's blog post on Alibaba's Qwen 3.8 27B open-weight model — strong model-quality review with the headline observation that the model "defaults to overthinking" (overly verbose reasoning chains). Strong topical fit to the LLM lane + agent lane (Qwen 3.8 27B is small enough to run on commodity hardware — adjacent to Robin's local-LLM stack at `/themes/04-local-llm.md`). **However** Qwen is open-weight, and the established scope rule ("open-weight AI never earns a `themes.md` row") applies — same rubric as the prior 2026-08-12 pull's `49273478` "Qwen3.8-2.4T-A95B" (200 pts) and `49272534` "Qwen 3.8-27B goes openweight in 2 days" (15 pts), and the 2026-08-10 pull's `49274950` "Qwen3.8-2.4T" (17 pts). The recurrence is real (this is the **third Qwen 3.8× item across three pulls in 7 days**) but per scope discipline the findings stay adjacent-not-promoted. **Adjacent-not-promoted** per brief. The 732-pt engagement is the highest single-item engagement of any HN item since the 2026-08-10 pull's Muse Glimmer (759 pts) — it would qualify for a `themes.md` row if Qwen were on Robin's named stack, but Qwen is open-weight and off-scope. **No commitment row** — Robin's local-LLM stack at `/themes/04-local-llm.md` tracks Ollama / bge-reranker / RAGFlow / LM Studio, and adding Qwen 3.8 27B as a local-LLM candidate is a Robin-workflow decision not yet signaled; if Robin starts running Qwen 3.8 27B locally on a future pull, the existing `/themes/04-local-llm.md` "Backlog" candidate becomes a follow-up.
|
||||
- **`49324087` "Anthropic's 'watermark' text adulteration in Claude is a perversion of writing"** (670 pts, 577 cmts, top+best feed, by `ropbear`, https://daringfireball.net/2026/08/anthropics_watermark_text_adulteration_in_claude_is_a_perversion_of_writing). Daring Fireball essay on Anthropic's Claude text watermarking as a "perversion of writing". Strong engagement (670 pts, 577 cmts). **Adjacent to the Claude / Claude Code lane** (per the 2026-08-13 pull's `49281916` Codex in ChatGPT desktop app for Linux, the 2026-08-10 pull's `49239021` Auto mode default in Claude Code, and the 2026-08-08 18:00 pull's `49215786` Claude Bluetooth-tracking anecdote) but **not** on Robin's named daily-driver stack. Adjacent-not-promoted per scope discipline ("Claude Code wrapper / TUI / usage changes stay adjacent-not-promoted unless there is a direct change to Hermes / MiniMax / OpenWiki / Codex CLI itself" — see the traceability entries below).
|
||||
- **`49323381` Stripe acquires OpenRouter** (already covered above) plus **all other feed items not promoted** (28 items in the 25-pt+ engagement tail) are off-scope per the brief's scope filter — `49330781` "A Preview of DuckDB v2.0" (305 pts, 48 cmts, top+best, https://duckdb.org/2026/08/17/duckdb-20-highlights — DuckDB is a columnar DBMS, adjacent to Robin's SQLite-backed services but on a different DBMS; off-scope); `49330597` "Incident with Github.com" (226 pts, 708 cmts, top, by `SpyCoder77` — GitHub status incident; real-but-incidental exposure on Robin's stack but Robin's primary git is Gitea per `/themes/05-robin-research.md`; flagged for traceability because the 226-pt + 708-cmt engagement is the highest comment count of the pull but the incident is on `github.com` not `gitea`); `49330684` "Incident with Github.com" (691 pts, 2 cmts, best — same GitHub incident from the best feed); `49330632` "GitHub down again? no PR access" (288 pts, 2 cmts, best — Ask HN thread on the same GitHub incident); `49329575` "GPT 5.6 Sol is the best 'vision' model OpenAI ever released" (216 pts, 108 cmts, top+best, by `plurby`, https://blog.roboflow.com/openai-gpt-5-6/ — OpenAI GPT 5.6 Sol vision-model release; off-scope per brief); `49325789` "On AI regulation and messaging" (208 pts, 415 cmts, top+best, by `jacquesm` — Dario Amodei Twitter post on AI regulation; off-scope AI policy); `49326816` "Linear algebra done right" (208 pts, 79 cmts, top+best, https://linear.axler.net/ — math textbook page; off-scope); `49325061` "Reticulum – Decentralized Mesh Network" (205 pts, 65 cmts, top+best — mesh-network open-source project; off-scope); `49323686` "Nvidia dramatically reduces amount of OpenAI infra financing it may guarantee" (236 pts, 137 cmts, best, https://www.reuters.com/business/nvidia-scales-back-250-billion-openai-data-center-guarantee-wsj-reports-2026-08-14/ — Nvidia/OpenAI infrastructure deal reduction; off-scope infrastructure news); `49332981` "Universal Health Coverage Could Save $1T and 114k Lives a Year, Yale Study" (291 pts, 391 cmts, best, https://ysph.yale.edu/news-article/universal-health-coverage-could-save-one-trillion-dollars-and-114000-lives-every-year/ — Yale SPH study on UHC; off-scope clinical health economics); `49325159` "The federal keyword lists that canceled billions in research funding" (267 pts, 159 cmts, best, https://www.highereddive.com/news/inside-the-federal-keyword-lists-that-canceled-billions-in-research-funding/826203/ — research funding policy; off-scope); `49326156` "GIMP Development Update" (245 pts, 225 cmts, best, https://www.gimp.org/news/2026/08/16/dev-update-august-2026/ — GIMP release notes; off-scope graphics); `49322695` "Models Are Getting Dumber on Purpose" (326 pts, 181 cmts, best, https://w4g1.dev/blog/models-are-getting-dumber-on-purpose — AI alignment essay; off-scope); `49331033` "Ask HN: Alternatives to GitHub" (293 pts, 180 cmts, top+best, by `dhruv3006` — Robin's stack uses Gitea primarily per the 2026-08-12 / 2026-08-13 / 2026-08-15 traceability notes; Ask HN discussion, off-scope but adjacent to the ITX 24h host build commitment per `/commitments.md` `itx-24h-host-build-2026-q3`); `49330456` "Online clinics and influencers are promoting Cialis as a longevity drug" (79 pts, 57 cmts, top, https://www.npr.org/2026/08/17/nx-s1-5928263/cialis-viagra-tadalafil-longevity-heart-health — clinical pharmacology news; off-scope); `49332564` "Anthropic's War on open source AI" (64 pts, 21 cmts, top — Twitter thread on Anthropic's relationship to open-source AI; off-scope AI policy); `49331474` "How to put 170 atoms in an atom" (58 pts, 5 cmts, top — chemistry retro; off-scope); `49332751` "Launch HN: Speko (YC S26) – OpenRouter for Voice AI" (52 pts, 23 cmts, top — YC S26 voice-AI router launch at https://speko.ai/; adjacent to the AI-inference lane but voice-specific; off-scope); `49331551` "Show HN: Saggar, a Mac terminal that keeps sessions and your attention organized" (23 pts, 17 cmts, top, by `mcclowes`, https://saggar.marginalutility.dev/ — terminal app; off-scope); `49327643` "Show HN: Desktopcolors.com – A museum for solid background colors of classic OS" (105 pts, 42 cmts, top — design/retro essay; off-scope); `49333932` "Buy Your Friends Batteries" (60 pts, 63 cmts, top — lifestyle essay; off-scope); `49323474` "How I developed an Am29000 C compiler and web browser" (48 pts, 5 cmts, top — retro computing essay; off-scope); `49331555` "The only known trebuchet casualty in history" (49 pts, 13 cmts, top — archaeology essay; off-scope); `49330215` "Show HN: Sokoban AI Solver" (49 pts, 31 cmts, top — Show HN; off-scope); `49330978` "How to ship a database every day" (46 pts, 6 cmts, top — Turbopuffer engineering blog on control plane; off-scope); `49331220` "How to disable or avoid intrusive AI" (130 pts, 54 cmts, top — librarian.net essay; off-scope); `49331222` "Apple's App Tracking Transparency trLine truncated
|
||||
- **Synthesis result:** **no theme refresh, no commitment row, no open-question row, no personal-logistics item.** The `class-organoid-3d-bioprinting` row on `/themes.md` stays at Last seen 2026-08-12 (no organoid item — the 6 organoid Algolia hits are all string-collision noise). The `agent-memory-architecture` row stays at Last seen 2026-08-13 (the `49332326` Agent Mesh 1-pt Show HN is too low-engagement to refresh Last seen per the established "Watchlist promotion requires recurrence, strong engagement, or corroboration" rule, and the implementation uses SQLite + decision log rather than OKF frontmatter). The `MiniMax-m3` row stays at Last seen 2026-08-03 (no MiniMax model release; `49323381` Stripe-OpenRouter is an upstream business event, not a MiniMax change). The `hermes-agent-v0-19-quicksilver` row stays at Last seen 2026-08-03 (no Hermes Agent release; `49331423` Copilot Autofix is a GitHub Copilot incident, not a Hermes Agent incident). The `openwiki-brand` watchlist row stays at Last seen 2026-07-16 (no positive `openwiki` hits). All three flag-for-traceability items stay adjacent-not-promoted under the existing scope discipline. **Key calls**:
|
||||
- **`49323381` Stripe acquires OpenRouter for $7B+** (439 pts, 271 cmts) is the **strongest single business event in the AI inference lane this pull** — the $7B+ acquisition value is the largest AI-infrastructure deal on this pull and the OpenRouter-as-MiniMax-adjacent inference-provider angle is the cleanest single touchpoint to Robin's Hermes Agent / MiniMax-M3 stack since the 2026-07-30 Tavily Hermes Agent API server documentation refresh. Adjacent-not-promoted per scope (Stripe + OpenRouter are not on Robin's named stack), but flagged here because (a) the 439-pt + 271-cmt engagement is high enough to surface in any HN digest; (b) the OpenRouter-MiniMax adjacency is the most concrete inference-routing change in the public AI lane since the 2026-08-03 MiniMax-H3 launch cluster; and (c) any Hermes / MiniMax-side response on a future pull (e.g. MiniMax updating its API-pricing terms in response to the acquisition, or Hermes adding OpenRouter as a named inference provider) becomes a `MiniMax-m3` row annex candidate.
|
||||
- **`49331423` AI-Generated Copilot "Autofix" Allowed Compromise of Snowflake's Jira** (168 pts, 81 cmts) is the **strongest agent-supply-chain / agent-tool-use security incident** to surface on HN top since the 2026-07-30 Databricks "Managing AI Coding Costs at Scale" (290 pts best) adjacent-only item. Adjacent-not-promoted per scope (GitHub Copilot incident, not a Hermes / MiniMax / OpenWiki incident), but flagged here because (a) the Snowflake Jira production compromise via an AI-generated code suggestion is the canonical 2026-08 working example of agent-tool-use reaching production with a security bypass; (b) Hermes Agent v0.19 Quicksilver's live subagent feature (per [`/themes/03-ai-agents.md`](/themes/03-ai-agents.md)) and Codex CLI's `codex exec` command-confirmation flow are the two agent surfaces on Robin's named stack that handle tool-use, so any future Hermes / Codex-side response to the broader Copilot Autofix incident is a `themes.md` row annex candidate for `hermes-agent-v0-19-quicksilver`.
|
||||
- **`49332326` Agent Mesh – Shared memory for multi-Agent coordination** (1 pt, Show HN) is the **first HN item this year to surface an explicit "shared memory + decision log + human-approval gate" architecture** that mirrors the `agent-memory-architecture` theme at the macro level — adjacent-not-promoted because (a) 1-pt engagement is below the established refresh threshold; (b) the implementation uses SQLite + ids rather than OKF frontmatter (the row's anchor schema); (c) it was surfaced as a string-collision noise hit on the `Cellink` Algolia query (word "calling" in body text), not because it relates to Cellink bioprinters. Flagged for traceability because (a) the architecture pattern (Human + multi-Agent shared memory + SQLite message bus + decision log + Workbench dashboard + Claude + CODEX via `codex exec` + all decision modifications require Human approval) is a new exact match on the `agent-memory-architecture` macro-pattern; (b) if a future HN item at higher engagement combines the Agent Mesh pattern with explicit OKF frontmatter reference, both items become corroborating evidence for a `themes.md` refresh.
|
||||
- **This is the sixth pull since 2026-08-07 to have an empty / noise-only Algolia lane on vendor queries** (after 2026-08-08 03:15 fully-zero + 2026-08-08 18:00 fully-zero + 2026-08-13 fully-zero + 2026-08-15 fully-zero + 2026-08-16 fully-zero; the 2026-08-10 + 2026-08-12 pulls were also noise-only on the substring queries). The pattern confirms that the empty-pulls-on-vendor-queries cadence is normal under the 6-query LLM-agent topic set — not an outage, no config-side intervention needed. The Tavily (web-search) lane remains the productive lane for vendor news; the HN lane's stable role is now "high-engagement inference-lane adjacents (Stripe/OpenRouter) + agent-stack security adjacents (Copilot Autofix) + show-HN agent-memory architecture watchlist (Agent Mesh) + life-science application-domain watchlist items (organoid / neuroscience / Wired features)" rather than vendor-direct signals. The 9-overlap dedup count between `top` and `best` (34 unique from 26+17) is the highest overlap ratio since the 2026-08-15 pull (4 overlap → 19 unique from 19+4) — the new `best` feed is contributing more deduped items, which is consistent with the higher weekday-evening HN front-page density than the 2026-08-15 Friday-afternoon pull.
|
||||
|
||||
| Query lane | Queries run | Qualifying results |
|
||||
| --- | --- | --- |
|
||||
| Life sciences / vendors | `organoid`, `CelVivo`, `3Brain`, `Cellink` | 0 (`organoid` → 6 noise hits on "organi-" substring; `CelVivo` → 0; `3Brain` → 6 noise hits on "brain" substring; `Cellink` → 6 noise hits on "calling" / "ceiling" / "celine" / "welling" substrings) |
|
||||
| AI workflow | `openwiki`, `deepagents` | 0 (both queries returned `nbHits=0`) |
|
||||
|
||||
Raw dump: `~/.openwiki/connectors/hackernews/raw/2026-08-17T18-00-01-808Z/hackernews-results.json`.
|
||||
|
||||
### Flag-for-traceability: Stripe acquires OpenRouter, AI-generated Copilot Autofix Snowflake Jira compromise, Qwen 3.8 27B on Simon Willison, Agent Mesh shared-memory Show HN — adjacent, off-scope
|
||||
|
||||
- **49323381** (439 pts best, 271 cmts) **Stripe will reportedly acquire OpenRouter for $7B+** — TechCrunch (https://techcrunch.com/2026/08/16/stripe-will-reportedly-acquire-ai-gateway-startup-openrouter-for-7b/, by `zacharyozer`). **Strongest single business event in the broader AI inference lane this pull**, on the same 2026-08-16 weekday evening as the Qwen 3.8 27B Simon Willison blog (49324985). OpenRouter is the AI model-routing gateway that aggregates DeepSeek / Qwen / Google / OpenAI / Anthropic / Mistral / Cohere / Perplexity / other vendor models under one inference API — it is a primary MiniMax-adjacent inference provider alongside the direct MiniMax-M3 HuggingFace + Tweet launch points documented on `/themes.md` `MiniMax-m3` row. Stripe is a payment-processor acquiring an AI-infrastructure gateway. The 439-pt + 271-cmt engagement makes this the highest-engagement business-side signal on this pull after the 732-pt Qwen 3.8 27B item. **Adjacent-not-promoted** per scope because (a) Stripe + OpenRouter are not on Robin's named daily-driver stack (Hermes / MiniMax-M3+H3 / OpenWiki / RAGFlow / NocoDB / SeaFile / Codex CLI); (b) the established scope rule on inference-provider business events keeps them adjacent-not-promoted unless there is a direct change to Hermes / MiniMax / OpenWiki / Codex CLI itself (per the 2026-07-30 / 2026-08-03 / 2026-08-10 / 2026-08-12 / 2026-08-13 / 2026-08-15 / 2026-08-16 traceability entries); (c) although OpenRouter is not open-weight, the rubric "inference-provider changes only refresh `themes.md` when there is a direct change to Hermes / MiniMax / OpenWiki / Codex CLI itself" still applies — the acquisition is an upstream business event, not a vendor-stack change Robin acts on. **No commitment row** — Robin does not currently use OpenRouter as a primary inference path; if Robin adopts OpenRouter as a fallback inference provider on a future pull, or if a Hermes / MiniMax-side response to the acquisition surfaces (MiniMax changing its pricing terms in response, or Hermes adding OpenRouter as a named inference path), that becomes a `MiniMax-m3-row-annex-inference-routing-changes` candidate.
|
||||
- **49331423** (168 pts top, 81 cmts) **AI-Generated GitHub Copilot "Autofix" Allowed Compromise of Snowflake's Jira** — Wiz research blog (https://www.wiz.io/blog/red-agent-snowflake-copilot-cicd-bug, by `galnagli`). **Strongest agent-supply-chain / agent-tool-use security incident** to surface on HN top this year — a production security incident in which an AI-generated code suggestion from GitHub Copilot's "Autofix" (agentic self-fix) feature was allowed to merge into Snowflake's CI/CD pipeline and compromise the Snowflake Jira instance. The 168-pt + 81-cmt engagement is high enough to surface in any HN digest. Strong topical fit to Robin's broader Hermes Agent / Codex CLI / OpenWiki agent-tool-use lane — Hermes Agent v0.19 Quicksilver's live subagent feature performs tool-use calls to filesystem / shell / API tools with user-confirmation gates (per [`/themes/03-ai-agents.md`](/themes/03-ai-agents.md)), and Codex CLI's `codex exec` flow has its own command-confirmation gates. The Copilot Autofix → Snowflake Jira incident is the **canonical 2026-08 working example** of agent-generated code reaching production with a security-bypass in a vendor agent that did not have the right gates. **Adjacent-not-promoted** per scope because (a) the incident is at GitHub Copilot, not Hermes / MiniMax / OpenWiki / Codex CLI / RAGFlow / NocoDB / SeaFile; (b) the established scope rule on non-named-stack agent-security incidents keeps them adjacent-not-promoted unless there is a direct incident at a vendor in Robin's named stack; (c) the brief's "Workflow tooling priority LOW — surface story-worthy changes only" rule does not promote this to a `/themes.md` row by itself. **Adjacent-not-promoted** per scope. The 168-pt + 81-cmt engagement is high enough to surface in any HN digest. **No commitment row** — Robin's Hermes Agent + Codex CLI tool-use flow is already gated by the existing v0.19 Quicksilver configuration; if a future Hermes v0.20 patch / v0.21 release adds an explicit AI-coding-supply-chain audit hook in response to the Copilot Autofix incident on a future pull, that becomes a future-promotable commitment.
|
||||
- **49324985** (732 pts top+best, 344 cmts) **Qwen 3.8 27B is excellent, but it defaults to overthinking things** — Simon Willison blog (https://simonwillison.net/2026/Aug/16/qwen-38-27b/, by `bilsbie`). **Highest-engagement item of the pull.** Strong engagement (732 pts, 344 cmts) makes this the highest single-item engagement on any HN pull since the 2026-08-10 Muse Glimmer (759 pts, off-scope open-weight AI). Strong topical fit to the LLM + agent lane (Qwen 3.8 27B is a small-enough model to run on commodity hardware — adjacent to Robin's local-LLM stack at `/themes/04-local-llm.md`). **However** Qwen 3.8× is open-weight, and the established scope rule ("open-weight AI never earns a `themes.md` row") keeps it adjacent-not-promoted. Same rubric as the prior 2026-08-12 pull's `49273478` "Qwen3.8-2.4T-A95B" (200 pts) and `49272534` "Qwen 3.8-27B goes openweight in 2 days" (15 pts), and the 2026-08-10 pull's `49274950` "Qwen3.8-2.4T FP8" (17 pts). This is the **third Qwen 3.8× item across three pulls in 7 days** — a real recurrence pattern, but per scope discipline the findings stay adjacent-not-promoted. The "overthinking" headline observation is also worth flagging because it mirrors a broader 2026-08 LLM-trend observation (per `49270194` / `49272891` / `49329863` "Models Are Getting Dumber on Purpose" earlier in this pull's `best` feed at 326 pts — same theme of "model vendor intentional behaviour change in 2026-08 surfaces"). **Adjacent-not-promoted** per scope. **No commitment row** — Robin's local-LLM stack at `/themes/04-local-llm.md` tracks Ollama / bge-reranker / RAGFlow / LM Studio, and adding Qwen 3.8 27B as a local-LLM candidate is a Robin-workflow decision not yet signaled; if Robin starts running Qwen 3.8 27B locally on a future pull, the existing `/themes/04-local-llm.md` "Backlog" candidate becomes a follow-up.
|
||||
- **49324087** (670 pts top+best, 577 cmts) **Anthropic's 'watermark' text adulteration in Claude is a perversion of writing** — Daring Fireball essay (https://daringfireball.net/2026/08/anthropics_watermark_text_adulteration_in_claude_is_a_perversion_of_writing, by `ropbear`). Highest-comment-count essay of the pull. Strong topical fit to the Claude / Claude Code / Claude watermarking lane. Adjacent to the 2026-08-13 Codex in ChatGPT Linux desktop app + 2026-08-10 Auto mode default in Claude Code + 2026-08-08 Claude Bluetooth-tracking cluster, but **not** on Robin's named daily-driver stack. **Adjacent-not-promoted** per scope discipline ("Claude Code wrapper / TUI / usage changes stay adjacent-not-promoted unless there is a direct change to Hermes / MiniMax / OpenWiki / Codex CLI itself").
|
||||
- **49332326** (1 pt top, `Cellink` Algolia noise hit) **Show HN: Agent Mesh – Shared memory for multi-Agent coordination** — Show HN (https://github.com/cbalgeman/agent-mesh, by `balgeman`). Architectural pattern: Human + multi-Agent shared memory; SQLite Agent Mail (Agent-to-Agent message bus keyed on request/response id); decision log (keyed on id, mirrors the Karpathy LLM Wiki pattern of structured IDs in code comments / plan docs); Workbench web dashboard; Claude app + CODEX via `codex exec` agent-mesh bridge; all decision modifications require Human approval from the Workbench. Strong macro-pattern fit to the `agent-memory-architecture` theme at the macro level (shared memory + decision log + agent-coordination + human-approval gate) — same broad lane as OKF / MCP Memory / Karpathy LLM Wiki / MinIO AIStor Memory / Exabase BEAM. **However** (a) implementation uses SQLite + ids + workbench dashboard rather than OKF frontmatter (no `okf_version: "0.1"` reference), so it does not corroborate the existing row's OKF+memory schema pattern (the criterion that drove the 2026-08-13 MCP Memory / Google's OKF Last-seen refresh); (b) 1-pt engagement is well below the established refresh threshold of the prior MCP Memory (46 pts) and below the 100+ pts threshold for high-engagement vendor releases; (c) surfaced as a `Cellink` Algolia query string-collision noise hit on the word "calling" in body text — not because it relates to Cellink bioprinters. **Adjacent-not-promoted** per scope. **No commitment row, no open-question row, no `/themes.md` row refresh** — but flagged for traceability because (a) the macro-pattern (Human + multi-Agent + SQLite message bus + decision log + Workbench + Claude + CODEX via `codex exec` + Human-approval gate) is an exact match on the row's macro-pattern; (b) if a future HN item at higher engagement combines the Agent Mesh pattern with explicit OKF frontmatter reference, both items become corroborating evidence for a `themes.md` refresh.
|
||||
|
||||
## Update — 2026-08-16 18:00 UTC
|
||||
|
||||
- **Coverage:** 2 feeds (`top`, `best`), 6 search queries (the same simplified LLM-agent topic set from the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories": `organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents`). `top` feed returned 19 unique resolved items, `best` feed returned 12; deduplication gave **25 unique items across both feeds** (6 overlap: `49313428` Super El Niño, `49314235` Cultivating a state of mind, `49314902` Software Engineering fundamentals, `49319389` Research papers using "kidney disappointment", `49319556` Claude System Prompts, `49319633` Firefox for iOS native adblocker). The 6-query lane produced the hit table below; the connector completed normally at `fetchedAt: 2026-08-16T18:00:39.120Z` (24-hour window).
|
||||
- **Life-science lane:** **zero vendor-anchored hits across all four named vendor queries.** All six Algolia searches (`organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents`) returned `nbHits=0` in the 24 h window. A title/URL regex sweep across the 25 unique top+best items also turned up zero organoid / 3D-bioprinting / CelVivo / 3Brain / Cellink / ClinoStar / ClinoReactor / MEA / spheroid / organ-on-chip items. The "no material HN footprint for the 4 vendor lines" finding continues to hold — this is the **fifth pull since 2026-08-07 to have a fully-zero Algolia lane** (after the 2026-08-08 03:15 + 2026-08-08 18:00 + 2026-08-13 + 2026-08-15 pulls; the 2026-08-10 + 2026-08-12 pulls had Algolia hits that were all string-collision noise rather than fully-zero). The Tavily web-search lane remains the better signal for vendor news.
|
||||
|
||||
+2
-2
@@ -4,7 +4,7 @@
|
||||
- [Agents 代理商档案索引 — 跨 agent CRM 同步](agents.md) - Cross-agent index of the Obsidian vault 02-Clients/Agents/* profiles (which agents Robin is actively working with, mapped by vendor product line). Base identity only — sensitive fields (phone / WeChat / email / end-customer list / opportunity value) live only in the private vault. Updated 2026-08-07 with _known_associations.md product-line → agent → end-customer mapping.
|
||||
- [全国经销商地图 (2026-08-07 时点)](distributors-china-2026.md) - Compact index of Robin's 2026-08-07 China distributor baseline (259 dealers across 7 regions, replacing 261 in the 2026-07-24 baseline) plus the new product-association index _known_associations.md. Surfaces CelVivo ClinoStar → 济南成全 + FemtoBiomed CellShot → 9X Bio → TriArm Therapeutics chain. Routes pricing-sensitive fields to the private Obsidian vault per /sources/agents.md privacy rule.
|
||||
- [飞书邮箱 (Robin customer mailbox)](feishu-mail.md) - Planned cross-agent mailbox sync target for Robin's Feishu (飞书) mailbox (imap.feishu.cn:993 / imap.larksuite.com:993) — would let MiniMax code / Hermes recall 'what did Robin last discuss with customer X' from email metadata + summaries. Not yet provisioned — IMAP credentials + update script + crontab still pending Robin setup; this page documents the planned configuration and the sync policy that will be applied once provisioned.
|
||||
- [Git repo — evidence index (Obsidian vault, Robin)](git-repo.md) - Compact manifest of Robin's Obsidian vault + the local OpenWiki wiki, ingested through the local git-repo connector. Two configured repos: obsidian-vault at /home/ldw/workspace (main branch, HEAD 297f106d, 2026-08-12, unchanged across the 2026-08-13 / 2026-08-15 fetches) and openwiki-wiki at /home/ldw/.openwiki/wiki (main branch, HEAD 2507925, 2026-08-15). This page is a navigation index — content ingestion (paper deep reads, sales scripts, customer files) happens via the Hermes skill and RAGFlow, not here.
|
||||
- [Git repo — evidence index (Obsidian vault, Robin)](git-repo.md) - Compact manifest of Robin's Obsidian vault + the local OpenWiki wiki, ingested through the local git-repo connector. Two configured repos: obsidian-vault at /home/ldw/workspace (main branch, HEAD a4fa5a32, 2026-08-16, 7 new vault commits in the 2026-08-15T18:07Z → 2026-08-17T18:09Z 48-hour window) and openwiki-wiki at /home/ldw/.openwiki/wiki (main branch, HEAD be49285, 2026-08-17). This page is a navigation index — content ingestion (paper deep reads, sales scripts, customer files) happens via the Hermes skill and RAGFlow, not here.
|
||||
- [Hacker News — evidence index](hackernews.md) - Compact evidence trail for the Hacker News connector (hackernews-1, Robin-curated life-sciences + AI workflow). Synthesis lives on /themes.md, /commitments.md, etc.; this page only records ingestion coverage and notable items.
|
||||
- [文献精读 Master Template (Robin 7-27 实战版, "真适合浏览" 1 文件)](ldr-report-template.md) - Master template for Robin's literature-deep-read (LDR) pipeline — consolidates 4 literature skills (`literature-deep-read` / `research` / `review` / `curation-for-sales`) into a single 8-rule + 3-trigger + 5-section "真适合浏览" report format. Synthesized from 4-27 SOP范本 + 7-27 实战 lessons (Tasevska / Raji / Bosnjakovic). Triggers "精读吧" / "发 wikijs" / "入库" / "A" / Id/DOI/PMID/PDF signals into 4-step精简 or 8-step完整 flows. PDF全文必传 + PyMuPDF xref去重 + 9项强制 + SeaFile hostname `fb.biokingdom.top` + NocoDB v1 JSON + 3张真图 + `journal-year-topic` 报告路径.
|
||||
- [Bosnjakovic 2025 PAH 3D 球体代谢组学: 跟 CelVivo ClinoStar dynamic culture 关系 (Bosnjakovic 2025 bioRxiv)](literature-cel-bosnjakovic-2025-pah-deepread.md) - Deep-read synthesis of Bosnjakovic A et al. 2025 bioRxiv preprint (DOI 10.1101/2025.07.10.663939v1, 2025-07-10) — 21-day mature HepG2 3D spheroids with graded non-cytotoxic BaP + BBF (PAH代表物) exposure for metabolomics biomarker discovery. Robin's connection: 3D spheroid protocol maps directly onto CelVivo ClinoStar dynamic culture; supports PAH exposure metabolomics positioning for hepatotoxicity / NAFLD modeling applications. 精读 2026-07-27.
|
||||
@@ -14,7 +14,7 @@
|
||||
- [Raji 2026 (hMOs + 3Brain HD-MEA) — 7-27 增补版 (跟 7-01 矩阵集成)](literature-raji-2026-deepread.md) - Deep-read synthesis of Raji H, Bertoli F, Perez MJ, Lam A, Volpicelli-Daley LA, Deleidi M. 2026 Molecular Psychiatry (Nature 子刊, s41380-026-03667-4, DOI 10.1038/s41380-026-03667-4, IF 11) — human midbrain organoids (hMOs) with WNT modulation, dopaminergic neuron differentiation, bioreactor culture, and 3Brain HD-MEA electrophysiology for Parkinson's disease modeling. 7-01 实战范本 (page 1622) + 7-27 增补版 integrated with 3-paper 3Brain MEA matrix (Raji / Pali / Wei) and 4 product-line complementarity chain (CelVivo ClinoStar + Cellink BIO X + 3Brain HD-MEA + FemtoBiomed CellShot).
|
||||
- [Sharma 2026 — vascularized retinal organoid RGC survival and maturation (Cell Stem Cell)](literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md) - Deep-read synthesis of Sharma K et al. (2026) Cell Stem Cell — transiently vascularized human retinal organoids with RGC 18.2% vs ctrl-RO 1.21% at week 18, W31 ON/OFF/ON-OFF light responses, C3 endothelial monolayer integration strategy.
|
||||
- [3D 打印缓释 HCTZ 片: 跟 Cellink BIO X 挤出打印 (Tasevska 2025 EJPS)](literature-tasevska-2025-deepread.md) - Deep-read synthesis of Tasevska T et al. 2025 European Journal of Pharmaceutical Sciences 206:106998 (DOI 10.1016/j.ejps.2024.106998, 精读 2026-07-27) — first systematic SSE semi-solid extrusion vs DLP digital-light-processing comparison for sustained-release HCTZ (hydrochlorothiazide) tablets, with focus on SSE matching Cellink BIO X extrusion principle. Supports Robin's 3D-printed personalized-dose / sustained-release positioning and SSE extruder cross-sell narrative for Cellink BIO X accounts.
|
||||
- [Literature Deep-Reads — cross-agent deep-read index](literature.md) - Cross-agent index of Robin's literature deep-reads across the 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed) and adjacent application domains. Backed by the Obsidian vault 04-Literature/Deep-Reads/ and the flywheel-sync pipeline; synthesis pages are linked per paper.
|
||||
- [Literature Deep-Reads — cross-agent deep-read index](literature.md) - Cross-agent index of Robin's literature deep-reads across the 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed) and adjacent application domains (organoid IRB / ethics, vascularized organoids, microfluidic / organ-on-chip). Backed by the Obsidian vault 04-Literature/Deep-Reads/ and the flywheel-sync pipeline; synthesis pages are linked per paper.
|
||||
- [NocoDB 文献库索引 — 跨 agent 数据层](nocodb.md)
|
||||
- [OpenWiki Upgrade Drift (auto-generated)](openwiki-version-drift.md)
|
||||
- [OpenWiki 速查手册 (Robin 一次聊清, 直接拿来用)](OpenWiki%E9%80%9F%E6%9F%A5%E6%89%8B%E5%86%8C.md) - Compact OpenWiki cheat-sheet that condenses the 2026-07-27 6-conversation walkthrough into a single ready-to-share document. Designed for one-shot delivery to any agent / colleague / customer / manager who asks 'what is OpenWiki?' — covers the core concept, structure, sync model, and 4 active connectors in one page.
|
||||
|
||||
@@ -1,7 +1,7 @@
|
||||
---
|
||||
type: "Reference"
|
||||
title: "Literature Deep-Reads — cross-agent deep-read index"
|
||||
description: "Cross-agent index of Robin's literature deep-reads across the 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed) and adjacent application domains. Backed by the Obsidian vault 04-Literature/Deep-Reads/ and the flywheel-sync pipeline; synthesis pages are linked per paper."
|
||||
description: "Cross-agent index of Robin's literature deep-reads across the 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed) and adjacent application domains (organoid IRB / ethics, vascularized organoids, microfluidic / organ-on-chip). Backed by the Obsidian vault 04-Literature/Deep-Reads/ and the flywheel-sync pipeline; synthesis pages are linked per paper."
|
||||
tags: [literature, deep-read, flywheel, celvivo, 3brain, cellink, femtobiomed]
|
||||
---
|
||||
|
||||
@@ -13,6 +13,13 @@ tags: [literature, deep-read, flywheel, celvivo, 3brain, cellink, femtobiomed]
|
||||
|
||||
## Last 30 days of deep reads (mtime descending)
|
||||
|
||||
### 2026-08-16 (Quintard 2024 + Guo 2026 — 2 papers on the same day)
|
||||
|
||||
| DOI | Vendor | Application | Title (short) | Vault path |
|
||||
| --- | --- | --- | --- | --- |
|
||||
| `10.1038/s41467-024-45710-4` | CelVivo (ClinoStar rating 3 upstream) + Mimetas OrganoPlate (rating 4 direct) + Emulate Organ-Chip (rating 3) | Microfluidic platform for vascularized organoids | Quintard C et al. (2024) A microfluidic platform integrating functional vascularized organoids-on-chip (Nat Commun; 10 通道并行微流控芯片 + U 型捕获位 + hiPSC-BVO 30 天功能性灌注培养 + 跨类器官验证 [间充质球体 / BVO / 胰岛球体 / 肺类器官]; 血管层级化 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管, 壁剪切 27-2000 s⁻¹ 完美匹配人体毛细血管生理范围 50-1900 s⁻¹) — Wiki.js IDs 1719/1720/1722, NocoDB Id 3297; 4-commit LDR cycle 2026-08-16 (`0fc8db24` → `290e9635` → `24c713de` → `4073abf4`); last commit deleted the 3Brain reference per the SOP "硬门槛合规修正" cleanup rule | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` |
|
||||
| `10.3389/fcell.2026.1721946` | CelVivo (ClinoStar rating 4 clinical-translation IRB) + Mimetas OrganoPlate (rating 4 co-culture ethics) + Emulate Organ-Chip (rating 3) | Organoid research IRB / ethics systematic review | Guo Z & Zhang N (2026) Ethical review key considerations for organoid applications in biomedical research—a systematic review (Front Cell Dev Biol; 嘉兴市第一医院 + 嘉兴大学医学院视角; 类器官研究 IRB / 伦理审查 7 大强制要点系统综述 [样本来源/知情同意/数据隐私/共培养主体性/3R 动物福利/跨境监管/长期保存与终止使用] + 5 国对照 [中国《人类遗传资源管理条例》+《涉及人的生命科学和医学研究伦理审查办法》2023 / 美国 HIPAA + Common Rule + NIH GDS / 欧盟 GDPR + Clinical Trials Regulation 536/2014 / 日本 / 韩国]) — Wiki.js ID 1724, NocoDB Id 3298; 3-commit LDR cycle 2026-08-16 (`2e6f5989` → `00f824f2` → `a4fa5a32`); Robin translated the paper into a customer-facing IRB application checklist template at `templates/类器官IRB申请清单.md` v1.0 (180 lines; 7 mandatory points + 5 customer Q&A + China vs International flow + 10 attachments + 7 citations) | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` |
|
||||
|
||||
### 2026-08-09
|
||||
|
||||
| DOI | Vendor | Application | Title (short) | Vault path |
|
||||
|
||||
@@ -1,3 +1,9 @@
|
||||
---
|
||||
type: "Reference"
|
||||
title: "NocoDB 文献库索引 — 跨 agent 数据层"
|
||||
openwiki_generated: true
|
||||
---
|
||||
|
||||
# NocoDB 文献库索引 — 跨 agent 数据层
|
||||
|
||||
> 数据源: NocoDB 13 个文献库 + 2 个公司库 (实时,每次 OpenWiki cron 跑时更新)
|
||||
|
||||
@@ -1,3 +1,9 @@
|
||||
---
|
||||
type: "Reference"
|
||||
title: "RAGFlow 全文检索索引 (Robin KB system)"
|
||||
openwiki_generated: true
|
||||
---
|
||||
|
||||
# RAGFlow 全文检索索引 (Robin KB system)
|
||||
|
||||
> 数据源: RAGFlow (http://10.10.10.254:9980/) 14 个 KB 全文检索结果
|
||||
|
||||
@@ -1,3 +1,9 @@
|
||||
---
|
||||
type: "Reference"
|
||||
title: "SeaFile 大文件存储索引"
|
||||
openwiki_generated: true
|
||||
---
|
||||
|
||||
# SeaFile 大文件存储索引
|
||||
|
||||
> 数据源: SeaFile (http://10.10.10.254:9898/) 共 N 个资料库
|
||||
|
||||
+11
-3
@@ -2,12 +2,20 @@
|
||||
type: "Reference"
|
||||
title: "Web Search Evidence"
|
||||
description: "Compact, source-backed evidence and ingestion coverage for the web-search-1 Tavily lane tracking CelVivo, 3Brain, Cellink, and related organoid news."
|
||||
tags: [source, web-search, tavily, celvivo, 3brain, cellink, organoids, 2026-08-12, 2026-08-15, 2026-08-16]
|
||||
tags: [source, web-search, tavily, celvivo, 3brain, cellink, organoids, 2026-08-12, 2026-08-15, 2026-08-16, 2026-08-17]
|
||||
---
|
||||
|
||||
# Web Search Evidence
|
||||
|
||||
> Connector: `web-search-1` (Tavily). This page records compact, relevant evidence from Tavily pulls; search results are discovery leads, not vendor-confirmed announcements. Latest successful pull: 2026-08-03 18:08 UTC. The 2026-08-08, 2026-08-10, 2026-08-12, and 2026-08-15 update attempts were skipped because the connector is disabled and `TAVILY_API_KEY` is not present; no new 24-hour evidence was available on any of these four runs.
|
||||
> Connector: `web-search-1` (Tavily). This page records compact, relevant evidence from Tavily pulls; search results are discovery leads, not vendor-confirmed announcements. Latest successful pull: 2026-08-03 18:08 UTC. The 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, and 2026-08-17 update attempts were skipped because the connector is disabled and `TAVILY_API_KEY` is not present; no new 24-hour evidence was available on any of these five runs.
|
||||
|
||||
## 2026-08-17 attempted update — skipped
|
||||
|
||||
- **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
|
||||
- **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
|
||||
- **Coverage:** no raw data files were written for this attempted 24-hour window. The nightly searxng-fallback slot (`~/.openwiki/connectors/web-search/raw/2026-08-16T18-35-03-searxng-fallback/`) is also empty — no web-search evidence of any kind landed in the 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
|
||||
- **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
|
||||
- **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, 2026-08-12, and 2026-08-15 runs hit the same blocker; this is the **fifth consecutive skip on the same code path**.
|
||||
|
||||
## 2026-08-15 attempted update — skipped
|
||||
|
||||
@@ -15,7 +23,7 @@ tags: [source, web-search, tavily, celvivo, 3brain, cellink, organoids, 2026-08-
|
||||
- **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
|
||||
- **Coverage:** no raw data files were written for this attempted 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
|
||||
- **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
|
||||
- **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, and 2026-08-12 runs hit the same blocker; this is the fourth consecutive skip on the same code path.
|
||||
- **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, and 2026-08-12 runs hit the same blocker; the 2026-08-17 run hit the same blocker too. This was the fourth consecutive skip on the same code path at the time of the 2026-08-15 attempt (and the fifth skip including the 2026-08-17 follow-up).
|
||||
|
||||
## 2026-08-12 attempted update — skipped
|
||||
|
||||
|
||||
@@ -1,3 +1,9 @@
|
||||
---
|
||||
type: "Reference"
|
||||
title: "Wiki.js 索引 — 跨 agent 文档发布层"
|
||||
openwiki_generated: true
|
||||
---
|
||||
|
||||
# Wiki.js 索引 — 跨 agent 文档发布层
|
||||
|
||||
> 数据源: Wiki.js (http://10.10.10.254:3000/graphql) Biokingdom 实例
|
||||
|
||||
@@ -61,6 +61,7 @@ The state diagram shows the canonical CelVivo → 3Brain workflow: 3D suspension
|
||||
- **Bosnjakovic 2025 bioRxiv (PAH HepG2 3D spheroid, ClinoStar dynamic culture)** — 21-day maturation + 24h/96h BaP/BBF exposure; **4 metabolic markers (phenylalanine, TCA intermediates, GSH depletion, sphingolipid dysregulation) only appear in 3D, completely invisible in 2D**. Sales ammunition: "your 2D model is missing 100% of environmental toxicology early signals". Synthesis at [`/sources/literature-cel-bosnjakovic-2025-pah-deepread.md`](/sources/literature-cel-bosnjakovic-2025-pah-deepread.md).
|
||||
- **Miao 2025 Cell v2 (co-differentiation mesoderm + endoderm, vascularized lung/gut organoids, ClinoStar rotating culture)** — single 3D EB co-induction strategy yields **vHLPO with 7% ECs vs traditional HLPO 0%**, organ-specific endothelium + mesenchyme scRNA-seq validation, in-vivo functional integration with host circulation, FOXF1 mutation ACDMPV dual-pathology disease modeling. Product relevance: CelVivo ClinoStar rating 5 (co-differentiation depends on 3D EB self-organization in low-shear rotating culture — ClinoStar is the canonical hardware), HD-MEA rating 4, 3D bioprinting rating 3, patient-derived organoid drug screening rating 5. Synthesis at [`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`](/sources/literature-miao-2025-cell-vascularization-v2-deepread.md).
|
||||
- **Liu 2026 Nat Biomed Eng (shape-conformal porous framework for neural organoid e-phys, Rogers Lab)** — CelVivo ClinoStar rating 4 (organoid culture downstream of the shape-conformal framework; long-term maturation + functional readout is the canonical ClinoStar → HD-MEA workflow). Synthesis at [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md). See 3Brain evidence for the HD-MEA read side.
|
||||
- **Quintard 2024 Nat Commun (microfluidic platform integrating functional vascularized organoids-on-chip, 2026-08-16)** — CelVivo ClinoStar rating 3 (upstream workflow: BVO differentiation day 0-15 needs rotating-wall suspension culture; ClinoStar is the canonical hardware for this stage; the paper's day 15 → chip-on-board handoff is the canonical CelVivo → organ-on-chip workflow). Mimetas OrganoPlate rating 4 (direct Phaseguide-based vascularized / kidney / intestine organ-on-chip competitor — Robin's portfolio does not currently cover Mimetas but the platform represents a candidate cross-sell if Robin's customers ask "where do I run my CelVivo-matured organoids in a vascularized microenvironment?"). Emulate Organ-Chip rating 3 (Colon-Intestine-Liver platform companion). 10 通道并行微流控芯片 + hiPSC-BVO + 间充质球体 + 胰岛球体 + 肺类器官 跨类器官验证; 血管层级化 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管; 壁剪切 27-2000 s⁻¹ 完美匹配人体毛细血管生理范围 50-1900 s⁻¹. 4-commit LDR cycle 2026-08-16 (commits `0fc8db24` → `290e9635` → `24c713de` → `4073abf4` — last commit deleted the 3Brain reference per the SOP "硬门槛合规修正" cleanup rule because Quintard is organ-on-chip territory rather than 3Brain territory). Wiki IDs 1719/1720/1722, NocoDB Id 3297, DOI 10.1038/s41467-024-45710-4. Sales ammunition: "你的类器官前段培养到 day 15, 后段血管化怎么接? 我们的 CelVivo ClinoStar 提供 day 0-15 金标准旋转培养, 后接 Quintard 2024 微流控芯片做 30 天功能性血管化灌注". Customer entry: 药企临床前 (vascularized drug screening) + 微流控 organ-on-chip 平台集成商 (Mimetas / Emulate channel partners) + academic PI (vascular development / diabetes). Vault path: `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` (189 lines + 6 真图).
|
||||
- **Liang 2026 Sci Rep (mouse liver organoid 3-轨道 + fibrosis modeling, 2026-08-12)** — CelVivo ClinoStar rating 4 (P1-P10 长程扩增对应旋转培养 30+ 天无剪切; single DAPT only sustains P5, DAPT+Dex 协同才实现 P10 稳定成熟), CelVivo ClinoReactor rating 4 (单组织 3 轨道 [Hep/Cho/HSC] 分通道灌流; TGFβ 时间程序精确切换实现纤维化激活模型), CelVivo PhaseHolographic 成像 rating 3 (3D 球体直径/CV 实时 QC), 3Brain HD-MEA rating 3 (肝-神经互作延伸场景). 3 轨道 from 单份小鼠肝组织 (密度梯度离心 + 差速贴壁) → DAPT+Dex P1-P10 长程稳定成熟 (ALB / PAS / LDL / CYP 跨代保持) → TGFβ 5-7 天激活 qHSC → aHSC (Acta2/Col1a1 上调) → aHSC 共培养诱导 Hep-Orgs EMT (Snail/Twist/Vimentin ↑; ALB/CK8 ↓; Lgr5/EpCAM ↓; Ki67 ↓) = 体外肝纤维化模型. Wiki.js Id=1716, NocoDB Id=770, PMID 41857098. Page 946 9 项 SOP 重写版 + page 934 修齐 标杆 (4-commit LDR cycle 2026-08-12). **First deep-read whose `related:` field already names `[[MOC-类器官与3D培养]]`** on the day of publication — confirms MOC pattern in active use on real deep-reads. Vault path: `04-Literature/Deep-Reads/Liver/2026-08-12_Liang_2026_SciRep_liver_organoid_fibrosis_platform.md` (170 lines). Sales ammunition: "你的肝类器官只能短期培养? DAPT+Dex P1-P10 稳定成熟 + 单组织 3 轨道 + 14 天纤维化模型 — ClinoStar + ClinoReactor 一站搞定". Customer entry: 药企临床前 (抗纤维化药筛 14+ 天 3D 多细胞模型) + 临床肝活检中心 (1-2 mg 组织 → 3 周药敏 → ClinoReactor 6 通道一次测 6 药). Tracks in `/commitments.md` as `liang-2026-celvivo-clinostar-positioning`.
|
||||
- **Sales ammunition kit (CelVivo pricing + 8 Protocols + 5 app notes + 5 brand/whitepapers)** — Demo kit `10005-6` lists at €300 (Global Distributor Price, with special discount). 8 ClinoReactor Protocols cover prepare / media change / gardening / plate config / rotation-speed / alginate embed / VitroGel embed. 5 application notes cover HepG2/C3A liver, FTC-133 thyroid, NCI-H69V SCLC, TNBC, ClinoStar vs Orbital Shaker. Synthesis at [`/sources/sales-ammunition.md`](/sources/sales-ammunition.md).
|
||||
- **260528_CS vs OS app note (2026-07-17 deep read)** — ClinoStar vs Orbital Shaker shear-stress comparison for long-term 3D construct performance; ClinoStar has lower shear + long-term growth + better consistency. This is the **vs-competitor killer document** for "why not use an orbital shaker" customer questions.
|
||||
@@ -93,6 +94,7 @@ The state diagram shows the canonical CelVivo → 3Brain workflow: 3D suspension
|
||||
|
||||
- **China CDE cell & gene therapy classification rules (2026-07-24)** — affects CelVivo-class deals in the Chinese pharma R&D / CDMO customer base. Tracks in [`/commitments.md`](/commitments.md) `china-cde-cell-gene-therapy-rules-2026`.
|
||||
- **China Order No. 818 (effective 2026-05-01)** — accelerated clinical-translation pathway for cell therapy and 3D bioprinting at qualified hospitals. Tracks as `china-order-no-818-clinical-translation`.
|
||||
- **Guo 2026 Front Cell Dev Biol organoid IRB / ethics systematic review (2026-08-16)** — CelVivo ClinoStar ⭐⭐⭐⭐ clinical-translation IRB compliance; **Robin 推广 ClinoStar 给三甲医院时, 可附带 Guo 2026 框架作为增值**. The paper structures the IRB review framework as 7 mandatory points (sample provenance + donor informed consent + data privacy & de-identification + co-culture agency + animal welfare 3R + cross-border regulation + long-term storage & termination) + a 5-jurisdiction cross-border table (China《人类遗传资源管理条例》+《涉及人的生命科学和医学研究伦理审查办法》2023 vs US HIPAA + Common Rule + NIH GDS vs EU GDPR + Clinical Trials Regulation 536/2014 vs Japan / Korea). 3-commit LDR cycle 2026-08-16 (`2e6f5989` → `00f824f2` → `a4fa5a32`). Wiki.js ID 1724, NocoDB Id 3298, DOI 10.3389/fcell.2026.1721946. **Robin translated the paper into a customer-facing IRB application checklist template** at `templates/类器官IRB申请清单.md` v1.0 (180 lines; 7 mandatory points checklist + 5 customer Q&A + China vs International flow table + 10 attachments + 7 citations). Tracks in `/commitments.md` as `guo-2026-organoid-irb-checklist-rollout` (Owner: me; fold IRB application checklist into CelVivo industrial-customers program + Robin customer-training core material; commit the template and add a synthesis page at `/sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md`). Vault path: `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` (170 lines + 3 真图).
|
||||
- **China CGT 2026-07 developments** — Merck–Bio-Techne $11.3B acquisition, CARsgen satri-cel solid-tumor CAR-T approval (positive); gene-editing trial death + regulatory backlash (negative). Tracks as `china-cgt-2026-july-developments`.
|
||||
|
||||
## Cross-cutting relationship
|
||||
@@ -112,8 +114,11 @@ The state diagram shows the canonical CelVivo → 3Brain workflow: 3D suspension
|
||||
| What is Liu 2026's shape-conformal neural organoid e-phys story? | [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md) |
|
||||
| What is Sharma 2026's vascularized retinal organoid RGC story? | [`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`](/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md) |
|
||||
| What is Liang 2026's liver organoid fibrosis platform story? | `04-Literature/Deep-Reads/Liver/2026-08-12_Liang_2026_SciRep_liver_organoid_fibrosis_platform.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
|
||||
| What is Quintard 2024's vascularized organoid chip story? | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
|
||||
| What is Guo 2026's organoid IRB / ethics story? | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
|
||||
| What is the IRB application checklist for organoid research? | `templates/类器官IRB申请清单.md` v1.0 (vault path; untracked) |
|
||||
| What distributors am I actually working with? | [`/sources/agents.md`](/sources/agents.md) |
|
||||
| Which Chinese dealers carry our brand? | [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) |
|
||||
| What regulatory shifts affect our Chinese pharma deals? | [`/commitments.md`](/commitments.md) China CDE / Order No. 818 / China CGT items |
|
||||
| What regulatory shifts affect our Chinese pharma deals? | [`/commitments.md`](/commitments.md) China CDE / Order No. 818 / Guo 2026 IRB / China CGT items |
|
||||
| What conferences is 3Brain at this season? | [`/commitments.md`](/commitments.md) `3brain-coreplate-2026-conference-positioning` |
|
||||
| What's the CelVivo → 3Brain joint workflow? | [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) (this page) Workflow chain section |
|
||||
+33
-18
@@ -2,8 +2,8 @@
|
||||
type: "Reference"
|
||||
title: "Theme 5 · Robin's personal research (vendor deep reads + sales ammunition + CRM)"
|
||||
description: "Synthesis page for Robin's personal research portfolio — Obsidian vault + literature deep-read pipeline + sales ammunition + China distributor map + active CRM profiles + work-rhythm snapshots. Output routes into vendor themes 01 (organoid-equipment) and 02 (bioprinting)."
|
||||
tags: [theme, research, vault, deep-read, sales, crm, life-sciences, 2026-08-15, 2026-08-13]
|
||||
timestamp: 2026-08-15T18:07:49Z
|
||||
tags: [theme, research, vault, deep-read, sales, crm, life-sciences, 2026-08-17, 2026-08-15, 2026-08-13]
|
||||
timestamp: 2026-08-17T18:09:32Z
|
||||
---
|
||||
|
||||
# Theme 5 · Robin's personal research (vendor deep reads + sales ammunition + CRM)
|
||||
@@ -23,7 +23,7 @@ This is the synthesis page for **Robin 个人研究项目** — the durable body
|
||||
|
||||
```mermaid
|
||||
erDiagram
|
||||
VAULT["Obsidian vault (297f106d)"] ||--o{ DEEPREADS["Deep-read notes ~1,205"]
|
||||
VAULT["Obsidian vault (a4fa5a32)"] ||--o{ DEEPREADS["Deep-read notes ~1,207"]
|
||||
VAULT ||--o{ TRAIN["Sales training (CelVivo赋能培训 v1-v9)"]
|
||||
VAULT ||--o{ SALES["Active sales pipeline (惠百生物 PO + 中间商)"]
|
||||
VAULT ||--o{ CRM["Distributor profiles (董慧群 + 待补)"]
|
||||
@@ -32,6 +32,7 @@ erDiagram
|
||||
VAULT ||--o{ MEMORY["Daily + weekly reports (memory/ 147 .md)"]
|
||||
VAULT ||--o{ ITX["ITX 24h host build (untracked)"]
|
||||
VAULT ||--o{ MOC["MOCs (类器官与3D培养 first, +planned)"]
|
||||
VAULT ||--o{ TEMPLATES["Templates (类器官IRB申请清单 v1.0, untracked)"]
|
||||
|
||||
DEEPREADS }o--|| VENDOR["Vendor mapping"]
|
||||
VENDOR ||--|{ CelVivo["CelVivo (ClinoStar / ClinoReactor)"]
|
||||
@@ -50,19 +51,19 @@ The diagram shows Robin's research substrate: a single Obsidian vault with 8 buc
|
||||
|
||||
## Knowledge substrate: Obsidian vault
|
||||
|
||||
Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08-15T18:07:49Z):
|
||||
Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08-17T18:09:32Z):
|
||||
|
||||
| Field | Value |
|
||||
| --- | --- |
|
||||
| Repo path | `/home/ldw/workspace` |
|
||||
| Branch | `main` |
|
||||
| HEAD | `297f106d2b137af3480261052ff080cbc48d5b48` (**unchanged** across both 2026-08-13 and 2026-08-15 fetches — 0 new vault commits in the 2026-08-13T18:08Z → 2026-08-15T18:07Z 48-hour window; the 2026-08-12 Liang 2026 4-commit LDR cycle remains the most recent vault activity) |
|
||||
| Ahead of origin/main | 13 commits new since 2026-08-03 fetch (Fernandez Vallone 2026 + Microbioreactor 2026 + Liu 2026 v2-v11 + 4 经销商 hook 升级 + Wang 2024 Theranostics + **Phase A metadata batch + 2 sample runs** + **Liang 2026 liver organoid fibrosis platform 4-commit LDR cycle**); plus **23 untracked files** in working tree (unchanged from the 2026-08-13 fetch — 0 new untracked files appeared in the 2026-08-13T18:08Z → 2026-08-15T18:07Z 24-hour window) |
|
||||
| HEAD | `a4fa5a323d6dcabeb9eccad49e636ee6ba5f87a6` (**bumped** from `297f106d` at the 2026-08-17 fetch — **7 new vault commits** in the 2026-08-15T18:07Z → 2026-08-17T18:09Z 48-hour window: the 2026-08-16 Quintard 2024 Nat Commun microfluidic vascularized organoid chip 4-commit LDR cycle + the 2026-08-16 Guo 2026 Front Cell Dev Biol organoid ethics systematic review 3-commit LDR cycle — first time two new paper deep-reads landed on `main` in the same 48-hour window since the 2026-07-28 / 2026-07-29 Parate / Lee / Hodge cluster) |
|
||||
| Ahead of origin/main | 20 commits new since 2026-08-03 fetch (was 13 at the 2026-08-15 fetch; the +7 delta is the Quintard 2024 + Guo 2026 clusters) |
|
||||
| Auth | local path only — no remote, no credentials |
|
||||
| Working-tree state | dirty (1 nested-submodule + 1 untracked dir + 23 untracked files including 8 new `02-Clients/Agents/区域-2026-0807.md` + the still-untracked `Review/zhou2023_computer_vision_microfluidics.md` first-entry-in-Review/-subfolder file) |
|
||||
| Raw manifest | `~/.openwiki/connectors/git-repo/raw/2026-08-15T18-07-49-711Z/manifest.json` |
|
||||
| **Latest cluster (2026-08-12, unchanged across both 2026-08-13 + 2026-08-15 fetches)** | **Liang 2026 Sci Rep liver organoid fibrosis platform 4-commit LDR cycle** (`e542c977` adds file 186 lines → `8699a154` page 946 9 项 SOP 重写版 105+/122- → `aacba7aa` frontmatter title 改中文 1 line → `297f106d` page 934 修齐 5+/4-) — **net-new external evidence** (DOI 10.1038/s41598-026-42990-2, PMID 41857098, mouse liver 3-轨道 Hep-Orgs + Cho-Orgs + HSC + DAPT+Dex P1-P10 长程成熟 + TGFβ 激活体外纤维化模型) |
|
||||
| **Latest uncommitted file (2026-08-13, still-uncommitted at 2026-08-15)** | `04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md` — **first entry in the new `Review/` subfolder**; review-type papers stream separately from original-research stream; carry-forward status unchanged across the 2026-08-13 + 2026-08-15 fetches |
|
||||
| Working-tree state | dirty (23 untracked files + 2 new untracked directories — `celvivo_commercial/1331651_20260630_131201.pdf` + `templates/类器官IRB申请清单.md` — both untracked; the `Review/zhou2023_computer_vision_microfluidics.md` first-entry-in-Review/-subfolder is still-uncommitted, carrying forward from the 2026-08-13 fetch) |
|
||||
| Raw manifest | `~/.openwiki/connectors/git-repo/raw/2026-08-17T18-09-32-895Z/manifest.json` |
|
||||
| **Latest cluster (2026-08-16, replacing the 2026-08-12 Liang 2026 cluster)** | **Quintard 2024 Nat Commun + Guo 2026 Front Cell Dev Biol 7-commit LDR cluster** (`0fc8db24` Quintard adds file 189 lines → `290e9635` -v2 → `24c713de` -v3 → `4073abf4` -v4 → `2e6f5989` Guo adds file 170 lines → `00f824f2` -v2 → `a4fa5a32` -v3) — **net-new external evidence** (DOI 10.1038/s41598-026-42990-2, PMID 41857098, mouse liver 3-轨道 Hep-Orgs + Cho-Orgs + HSC + DAPT+Dex P1-P10 长程成熟 + TGFβ 激活体外纤维化模型) |
|
||||
| **Latest uncommitted artifact (2026-08-13 → 2026-08-17, multi-file)** | `04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md` (carry-forward untracked from 2026-08-13) + **2 new untracked directories added at the 2026-08-17 fetch**: `celvivo_commercial/1331651_20260630_131201.pdf` (6-30 quote PDF migrated into new folder) + `templates/类器官IRB申请清单.md` (180-line IRB application checklist derived from Guo 2026; Robin's first customer-facing template produced from a single deep-read — see the new Templates subtree below) |
|
||||
|
||||
### Vault navigation index (top-level folders)
|
||||
|
||||
@@ -91,7 +92,7 @@ Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08
|
||||
|
||||
| Subfolder | .md count | Vendor / scope |
|
||||
| --- | ---: | --- |
|
||||
| `Organoid/` | 659 | broad organoid literature |
|
||||
| `Organoid/` | 661 (+2 from 2026-08-16 — Quintard 2024 Nat Commun microfluidic vascularized organoid chip + Guo 2026 Front Cell Dev Biol organoid ethics systematic review) | broad organoid literature |
|
||||
| `Celvivo/` | 142 | CelVivo vendor + CelVivo-adjacent papers |
|
||||
| `3Brain/` | 136 | 3Brain vendor + 3Brain-adjacent papers |
|
||||
| `Cellink/` | 129 | Cellink vendor + Cellink-adjacent papers |
|
||||
@@ -110,8 +111,10 @@ Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08
|
||||
| `Microbioreactor/` | 1 | Rosero 2026 Front Bioeng Biotechnol (added 2026-08-07) |
|
||||
| `Cells/` | 1 | Fernandez Vallone 2026 Cells THSDC (added 2026-08-08) |
|
||||
| `Review/` | 1 | Zhou 2023 computer vision + microfluidics (added 2026-08-13, **untracked**) |
|
||||
| `Templates/` | 1 | `类器官IRB申请清单.md` v1.0 (2026-08-16, derived from Guo 2026 ethics deep-read, **untracked**; first customer-facing template produced from a single deep-read) |
|
||||
| `CelVivo-commercial/` | 1 | `1331651_20260630_131201.pdf` (2026-06-30 quote PDF migrated into new folder 2026-08-17, **untracked**) |
|
||||
|
||||
Total ≈ 1,204 deep-read notes on `main` + **1 untracked entry in the new `Review/` subfolder** (`zhou2023_computer_vision_microfluidics.md`, 2026-08-13 — first review-type subfolder; future-commit candidate). The 4 vendor subfolders (Celvivo / 3Brain / Cellink / Organoid) cover the canonical product KB per the wiki goal focus areas.
|
||||
Total ≈ 1,206 deep-read notes on `main` + **1 untracked entry in the new `Review/` subfolder** (`zhou2023_computer_vision_microfluidics.md`, 2026-08-13 — first review-type subfolder; future-commit candidate) + **2 new untracked directories** (`templates/类器官IRB申请清单.md` + `celvivo_commercial/1331651_20260630_131201.pdf`, 2026-08-17). The 4 vendor subfolders (Celvivo / 3Brain / Cellink / Organoid) cover the canonical product KB per the wiki goal focus areas. The new `templates/` folder signals Robin may be formalizing customer-facing deliverables (checklists / templates / sales scripts) as a separate vault subtree — the IRB application checklist is the first such artifact.
|
||||
|
||||
## Literature deep-read (LDR) pipeline
|
||||
|
||||
@@ -180,6 +183,8 @@ From [`/sources/ldr-report-template.md`](/sources/ldr-report-template.md) (Robin
|
||||
| Sharma 2026 Cell Stem Cell (2026-08-08 flywheel-sync) | 3Brain + CelVivo adjacent | `/home/ldw/workspace/retinal_organoid_deep_read_2026-08-07.md` | [`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`](/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md) |
|
||||
| Miao 2025 Cell v2 (2026-08-08 flywheel-sync) | CelVivo (ClinoStar rating 5) | `/home/ldw/workspace/Miao2025_Cell_v2.md` | [`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`](/sources/literature-miao-2025-cell-vascularization-v2-deepread.md) |
|
||||
| Liu 2026 Nat Biomed Eng (2026-08-08 flywheel-sync) | 3Brain (HD-MEA rating 5) + Cellink (microlattice rating 5) | `/home/ldw/workspace/Liu2026_NBME_shape_conformal_organoid.md` | [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md) |
|
||||
| Quintard 2024 Nat Commun (2026-08-16 vault LDR cluster) | CelVivo (ClinoStar rating 3 upstream) + Mimetas OrganoPlate (rating 4 direct) + Emulate Organ-Chip (rating 3) | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` | (not yet synthesized to `/sources/`) |
|
||||
| Guo 2026 Front Cell Dev Biol (2026-08-16 vault LDR cluster) | CelVivo (ClinoStar rating 4 clinical-translation IRB) + Mimetas OrganoPlate (rating 4 co-culture ethics) + Emulate Organ-Chip (rating 3) | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` | (not yet synthesized to `/sources/`; derived customer-facing template at `templates/类器官IRB申请清单.md` v1.0) |
|
||||
|
||||
## Recent 30-day research output (mtime 2026-06-16 → 2026-08-12)
|
||||
|
||||
@@ -187,6 +192,7 @@ From [`/sources/literature.md`](/sources/literature.md) last sync, broken out by
|
||||
|
||||
| Date | DOI / slug | Vendor | Topic |
|
||||
| --- | --- | --- | --- |
|
||||
| 2026-08-16 | **Quintard 2024 Nat Commun + Guo 2026 Front Cell Dev Biol 7-commit LDR cluster** (commits `0fc8db24` + `290e9635` + `24c713de` + `4073abf4` Quintard + `2e6f5989` + `00f824f2` + `a4fa5a32` Guo) | **CelVivo adjacent + Mimetas OrganoPlate ⭐⭐⭐⭐ + Emulate Organ-Chip ⭐⭐⭐** (Quintard) / **CelVivo ClinoStar ⭐⭐⭐⭐ + Mimetas OrganoPlate ⭐⭐⭐⭐ + Emulate Organ-Chip ⭐⭐⭐** (Guo) | Quintard C et al. (2024) A microfluidic platform integrating functional vascularized organoids-on-chip (Nat Commun DOI 10.1038/s41467-024-45710-4, Wiki ID 1719/1720/1722, NocoDB Id 3297; 10 通道并行微流控 + hiPSC-BVO 30 天功能性灌注培养 + 跨类器官验证 [间充质球体 / BVO / 胰岛球体 / 肺类器官]; 血管层级化 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管, 壁剪切 27-2000 s⁻¹, 完美匹配人体毛细血管生理范围 50-1900 s⁻¹) + Guo Z & Zhang N (2026) Ethical review key considerations for organoid applications in biomedical research—a systematic review (Front Cell Dev Biol DOI 10.3389/fcell.2026.1721946, Wiki ID 1724, NocoDB Id 3298; 嘉兴市第一医院 + 嘉兴大学医学院视角; 类器官研究 IRB / 伦理审查 7 大强制要点系统综述 [样本来源/知情同意/数据隐私/共培养主体性/3R 动物福利/跨境监管/长期保存与终止使用] + 中国《人类遗传资源管理条例》+ 国际 ISSCR/GDPR/HIPAA 多国对照表). **Robin translated Guo 2026 into a customer-facing IRB application checklist template** (`templates/类器官IRB申请清单.md` v1.0 180 lines) — first customer-facing template produced from a single deep-read. |
|
||||
| 2026-08-12 | **Liang 2026 liver organoid fibrosis platform 4-commit LDR cycle** (commits `e542c977` + `8699a154` + `aacba7aa` + `297f106d`) | **CelVivo (ClinoStar rating 5 + ClinoReactor rating 5)** | Liang Y et al. (2026) A robust mouse liver organoid platform enables sustained multicellular maturation and fibrosis modeling from a single tissue sample (Sci Rep DOI 10.1038/s41598-026-42990-2, PMID 41857098; Wiki.js Id 1716, NocoDB Id 770; 3 轨道 Hep-Orgs + Cho-Orgs + HSC 同步分离; DAPT+Dex P1-P10 长程稳定成熟 [ALB/PAS/LDL/CYP 跨代保持]; TGFβ 激活 qHSC → aHSC [Acta2/Col1a1 上调]; aHSC 共培养诱导 Hep-Orgs EMT [Snail/Twist/Vimentin↑; ALB/CK8↓; Lgr5/EpCAM↓; Ki67↓] = 体外肝纤维化模型) — page 946 9 项 SOP 重写版 + page 934 修齐 标杆; 7/7 Ollama qwen2.5vl 视觉审核通过; SeaFile 7/7 公网 200 验真. First paper whose `related:` field already names `[[MOC-类器官与3D培养]]` (the 2026-08-10 first MOC) on the day of publication. |
|
||||
| 2026-08-10 | **Phase A metadata batch + first MOC** (commits `d97b39ed` + `6b717aef` + `3b929c2f`) | (process discipline) | 6 deep-reads received the 6-field frontmatter (doi/journal/year/volume/pages/authors/pmid); first MOC `MOC-类器官与3D培养.md` (95 lines, 沙牛《AI 时代的 Obsidian 公开课》课时 1 pattern) created at `04-Literature/Deep-Reads/MOCs/`; 7 image alt descriptions added on `wang2024-org-on-chip.md`. No new external evidence. |
|
||||
| 2026-08-09 | `10.7150/thno.90492` (Wang 2024) | (4 类共性硬件 — Organoid-on-Chip 综述) | Wang H et al. (2024) Human organoids-on-chips for biomedical research and applications (Theranostics 14(2):788-818, PMID 38169573; 7 图覆盖 7 大主题板块) — Wiki.js ID 1700 (v2 - grp:3 ghost page 累加) |
|
||||
@@ -214,16 +220,18 @@ From [`/sources/literature.md`](/sources/literature.md) last sync, broken out by
|
||||
|
||||
By vendor (30-day mtime):
|
||||
|
||||
| Vendor | Most recent | 2026-08-08 / 2026-08-10 / 2026-08-12 additions |
|
||||
| Vendor | Most recent | 2026-08-08 / 2026-08-10 / 2026-08-12 / 2026-08-16 additions |
|
||||
| --- | --- | --- |
|
||||
| CelVivo | 2026-08-12 (Liang 2026 — ClinoStar rating 5 + ClinoReactor rating 5) | +Liang 2026 (P1-P10 长程成熟 + 单组织 3 轨道分通道灌流 + TGFβ 时间程序精确切换 — liver organoid fibrosis platform), +Miao 2025 v2 (ClinoStar co-differentiation), +Sharma 2026 (ClinoStar rating 3 adjacent), +Liu 2026 (ClinoStar rating 4 adjacent) |
|
||||
| 3Brain | 2026-08-08 (Liu 2026 — HD-MEA rating 5) | +Liu 2026 (shape-conformal framework, next-gen HD-MEA), +Sharma 2026 (HD-MEA rating 4 adjacent), +Shin 2024 (Phase A frontmatter hygiene on existing note) |
|
||||
| Cellink | 2026-07-27 (Tasevska 2025) | +Liu 2026 (microlattice fabrication rating 5 adjacent) |
|
||||
| CelVivo | 2026-08-12 (Liang 2026 — ClinoStar rating 5 + ClinoReactor rating 5) | +Liang 2026 (P1-P10 长程成熟 + 单组织 3 轨道分通道灌流 + TGFβ 时间程序精确切换 — liver organoid fibrosis platform), +Miao 2025 v2 (ClinoStar co-differentiation), +Sharma 2026 (ClinoStar rating 3 adjacent), +Liu 2026 (ClinoStar rating 4 adjacent), +Quintard 2024 (CelVivo ClinoStar rating 3 — upstream workflow step: BVO day 0-15 needs rotating-wall suspension culture), +Guo 2026 (CelVivo ClinoStar rating 4 — clinical-translation IRB compliance for 三甲医院 客户) |
|
||||
| 3Brain | 2026-08-08 (Liu 2026 — HD-MEA rating 5) | +Liu 2026 (shape-conformal framework, next-gen HD-MEA), +Sharma 2026 (HD-MEA rating 4 adjacent), +Shin 2024 (Phase A frontmatter hygiene on existing note), **−3Brain reference removed from Quintard 2024 -v4 (per commit `4073abf4` — "精读 Quintard 2024 -v4 (转发语标题/落款加粗/删3Brain)" was the explicit SOP rule "硬门槛合规修正" cleanup; Quintard is vendor-adjacent CelVivo/Mimetas/Emulate rather than 3Brain territory)** |
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| Cellink | 2026-07-27 (Tasevska 2025) | +Liu 2026 (microlattice fabrication rating 5 adjacent), **+Quintard 2024 (microfluidic organ-on-chip adjacent, no direct Cellink rating — but the platform architecture is a candidate cross-sell with Cellink BIO X for vascularized scaffold fabrication)** |
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| Adjacent (no vendor) | 2026-08-08 (Sharma 2026 retinal vascularization) | +Sharma 2026 (retinal organoid application domain) |
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| (Process discipline) | 2026-08-10 (Phase A batch + first MOC) | +6 deep-reads received 6-field frontmatter; +first MOC `MOC-类器官与3D培养.md` created; +7 image alt descriptions on Wang 2024 — no new external evidence |
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| (Subfolder expansion, uncommitted) | 2026-08-13 (new `Review/` subfolder) | +1 untracked file `Review/zhou2023_computer_vision_microfluidics.md` (first review-type subfolder — review papers stream separately from original research) |
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| (Customer-facing template, uncommitted) | 2026-08-16 (new `templates/` subfolder + IRB application checklist v1.0) | +1 untracked file `templates/类器官IRB申请清单.md` 180 lines (Guo 2026 ethics deep-read → IRB checklist template; 7 mandatory points + 5 customer Q&A + China vs International flow + 10 attachments + 7 citations; Robin's first customer-facing template produced from a single deep-read; will route into CelVivo industrial-customers program once committed) |
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| (Commercial quote PDF, untracked) | 2026-08-17 (new `celvivo_commercial/` subfolder) | +1 untracked file `celvivo_commercial/1331651_20260630_131201.pdf` (6-30 quote PDF migrated into a new folder; companion to the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree) |
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The pipeline is **vendor-balanced** — CelVivo, 3Brain, Cellink each have a recent deep read, and the 2026-08-08 flywheel-sync adds **3 papers spanning all 3 primary vendors + the retinal organoid application domain** (Sharma), all 3 rated 4-5 on at least one vendor's product line. The 2026-08-10 cluster is **process discipline** (Phase A metadata batch + first MOC creation + Wang 2024 alt-description sample), not new external evidence — the 6 deep-reads already existed on `main`; the 3 commits only normalize their metadata and add a knowledge-graph index layer. The 2026-08-12 cluster adds **net-new external evidence**: Liang 2026 Sci Rep liver organoid fibrosis platform (4-commit LDR cycle on a single paper, CelVivo ClinoStar ⭐⭐⭐⭐ + ClinoReactor ⭐⭐⭐⭐); this is the **first paper on `main` whose `related:` field already names `[[MOC-类器官与3D培养]]` on the day of publication**, confirming the MOC pattern is in active use on real deep-reads (vs the prior 2026-08-10 "MOC `related:` lists future MOCs" framing which was only prospective). The **first entry in the new NocoDB table `Robin_Picked_Papers`** is Liu 2026 (created 2026-08-08 per Robin instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage). The **first MOC** `MOC-类器官与3D培养.md` is the start of a Map-of-Content layer Robin appears to be building (the MOC's own `related:` already names `[[MOC-3Brain-HD-MEA]]` as the next planned MOC). The 2026-08-13 cluster (no vault commits, 1 new untracked file) **adds a new `Review/` subfolder to the deep-read tree** — Robin appears to be expanding the folder taxonomy to separate review-type papers from original-research papers; whether this is a one-off subfolder or the start of a recurring folder pattern is a watchlist item for the next git-repo fetch.
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The pipeline is **vendor-balanced** — CelVivo, 3Brain, Cellink each have a recent deep read, and the 2026-08-08 flywheel-sync adds **3 papers spanning all 3 primary vendors + the retinal organoid application domain** (Sharma), all 3 rated 4-5 on at least one vendor's product line. The 2026-08-10 cluster is **process discipline** (Phase A metadata batch + first MOC creation + Wang 2024 alt-description sample), not new external evidence — the 6 deep-reads already existed on `main`; the 3 commits only normalize their metadata and add a knowledge-graph index layer. The 2026-08-12 cluster adds **net-new external evidence**: Liang 2026 Sci Rep liver organoid fibrosis platform (4-commit LDR cycle on a single paper, CelVivo ClinoStar ⭐⭐⭐⭐ + ClinoReactor ⭐⭐⭐⭐); this is the **first paper on `main` whose `related:` field already names `[[MOC-类器官与3D培养]]` on the day of publication**, confirming the MOC pattern is in active use on real deep-reads (vs the prior 2026-08-10 "MOC `related:` lists future MOCs" framing which was only prospective). The **first entry in the new NocoDB table `Robin_Picked_Papers`** is Liu 2026 (created 2026-08-08 per Robin instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage). The **first MOC** `MOC-类器官与3D培养.md` is the start of a Map-of-Content layer Robin appears to be building (the MOC's own `related:` already names `[[MOC-3Brain-HD-MEA]]` as the next planned MOC). The 2026-08-13 cluster (no vault commits, 1 new untracked file) **adds a new `Review/` subfolder to the deep-read tree** — Robin appears to be expanding the folder taxonomy to separate review-type papers from original-research papers; whether this is a one-off subfolder or the start of a recurring folder pattern is a watchlist item for the next git-repo fetch. **The 2026-08-16 cluster (Quintard 2024 + Guo 2026) is the largest single-window vault delta since the 2026-07-28 / 2026-07-29 cluster** — 7 new vault commits spanning 2 new paper deep-reads, 2 new untracked working-tree directories, and 1 customer-facing sales-ammunition template derived from a single deep-read. The Quintard 2024 microfluidic / organ-on-chip platform (CelVivo ClinoStar upstream + Mimetas OrganoPlate direct competitor + Emulate Organ-Chip) extends Robin's vendor mapping into the organ-on-chip product lane that his portfolio doesn't currently cover; the Guo 2026 organoid ethics systematic review (7 mandatory points + 5 jurisdiction comparison) introduces the IRB / ethics domain to Robin's deep-read set and spawned `templates/类器官IRB申请清单.md` (180 lines, Robin's first customer-facing template) as the canonical "Robin 培训客户 IRB 申请" core material. The new `templates/` + `celvivo_commercial/` directories appear alongside the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree — Robin may be formalizing customer-facing deliverables (checklists / templates / sales scripts) as a separate vault subtree. The `Review/zhou2023_computer_vision_microfluidics.md` carry-forward untracked file is still-uncommitted at this fetch (now 4 days past the 2026-08-13 first observation); the watchlist trigger is if it remains uncommitted at the next fetch.
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## Sales ammunition pipeline
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@@ -237,6 +245,8 @@ Robin maintains a working sales library that consumes LDR output and routes into
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||||
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Cross-link to the canonical synthesis: [`/sources/sales-ammunition.md`](/sources/sales-ammunition.md).
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||||
**2026-08-16 addition — `templates/类器官IRB申请清单.md` v1.0** (180 lines, Robin 8-16 实战沉淀, **untracked**; derived from Guo 2026 Front Cell Dev Biol IRB / ethics systematic review — Wiki.js ID 1724, NocoDB Id 3298). The IRB application checklist is **Robin 第一份 customer-facing template produced from a single deep-read** and consists of: (a) **7 强制要点** [样本来源合法性 + 捐赠者知情同意 + 数据隐私与去标识化 + 共培养产物主体性评估 + 动物福利 3R + 跨境监管合规 + 长期保存与终止使用]; (b) **5 customer Q&A** [类器官研究是否要 IRB 申请 / 类器官共培养产品怎么申请 IRB / 类器官跨境研究怎么报 / 3R 原则怎么写 / 类器官 + 免疫细胞共培养 = CAR-T 体外培养, 算不算新生物体]; (c) **China vs International flow comparison table** [中国 2023 新规 vs 美国 Common Rule vs 欧盟 GDPR]; (d) **10 申请附件清单** [IRB 申请表 + 知情同意书 + 研究方案 + DMP + 样本采集机构 IRB 批件 + ...]; (e) **7 引用** [Guo 2026 + ISSCR 2021 + OHRP 2016 + GDPR + 中国 2023 + 中国 2019 + Cambridge 2020]. **Vendor relevance**: CelVivo ClinoStar ⭐⭐⭐⭐ (the 7 mandatory points directly apply to ClinoStar customer IRB submissions; **Robin 推广 ClinoStar 给三甲医院时, 可附带本框架作为增值**). Tracks as `/commitments.md` `guo-2026-organoid-irb-checklist-rollout` (Owner: me; fold IRB application checklist into CelVivo industrial-customers program + Robin customer-training core material; commit `templates/类器官IRB申请清单.md` and add a synthesis page at `/sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md`).
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||||
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||||
## Sales training cluster (working-tree additions)
|
||||
|
||||
Per `/sources/git-repo.md` §"Notable entities", `06-Sales/Content/Training-Materials/` contains the following working-tree additions not yet on `main`:
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||||
@@ -307,6 +317,8 @@ A dedicated subfolder under `05-Documents/Products/Celvivo/Industrial-Customers/
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||||
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||||
This is a self-contained CelVivo China commercial effort. The latest mtime census (2026-07-16 snapshot) shows `CelVivo_中国工业客户开发研究报告_20260626_v2.md` as the most-recent file (18 KB, 06-26 11:52). Documented at [`/sources/git-repo.md`](/sources/git-repo.md) §Notable entities.
|
||||
|
||||
**2026-08-17 working-tree addition — `celvivo_commercial/1331651_20260630_131201.pdf`** (56 KB, 2026-06-30 quote PDF migrated into a new folder; **untracked**) — companion to the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree. The new folder name signals Robin may be consolidating "Celvivo commercial" documents into a separate vault subtree rather than continuing to nest them under `05-Documents/Products/Celvivo/Industrial-Customers/` (which is the prior convention). If the convention holds, future CelVivo commercial PDFs / quotes / pricing tables will land in `celvivo_commercial/` instead of `05-Documents/Products/Celvivo/Industrial-Customers/`; if it doesn't hold, it's a one-off folder for the 6-30 quote. Watchlist trigger: if a second PDF or commercial doc lands in `celvivo_commercial/` by the next git-repo fetch, the convention change is real; if it stays single-entry, it's a one-off.
|
||||
|
||||
## Work-rhythm snapshot (2026-07-16)
|
||||
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||||
From [`/sources/vault-mtime-snapshot-2026-07-16.md`](/sources/vault-mtime-snapshot-2026-07-16.md) (last full mtime census):
|
||||
@@ -398,4 +410,7 @@ These are source-anchored but not vendor-anchored — they live here for traceab
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||||
| How does the agent stack consume this output? | [`/themes/03-ai-agents.md`](/themes/03-ai-agents.md) |
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||||
| How does the local-LLM fleet host this evidence? | [`/themes/04-local-llm.md`](/themes/04-local-llm.md) |
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||||
| Where does CelVivo + 3Brain output land? | [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) |
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||||
| Where does Cellink output land? | [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md) ||
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||||
| Where does Cellink output land? | [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md) |
|
||||
| What does Quintard 2024 say about vascularized organoid chips? | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
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||||
| What does Guo 2026 say about organoid IRB ethics? | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
|
||||
| What's the IRB application checklist for organoid research? | `templates/类器官IRB申请清单.md` v1.0 (vault path; untracked) ||
|
||||
Reference in new issue
Block a user