From 812779732b74da49bc1d3194a1b3d755e2b0774c Mon Sep 17 00:00:00 2001
From: OpenWiki Bot <openwiki@local>
Date: Tue, 18 Aug 2026 02:23:43 +0800
Subject: [PATCH] chore: daily update 2026-08-18

---
 .last-update.json               |   4 +-
 commitments.md                  |   9 +-
 index.md                        |   1 +
 quickstart.md                   |  18 +-
 sources/README.md               |   8 +-
 sources/git-repo.md             | 408 ++++++++++++++++++++++++--------
 sources/hackernews.md           |  40 +++-
 sources/index.md                |   4 +-
 sources/literature.md           |   9 +-
 sources/nocodb.md               |   6 +
 sources/ragflow.md              |   6 +
 sources/seafile.md              |   6 +
 sources/web-search.md           |  14 +-
 sources/wikijs.md               |   6 +
 themes/01-organoid-equipment.md |   7 +-
 themes/05-robin-research.md     |  51 ++--
 16 files changed, 462 insertions(+), 135 deletions(-)

diff --git a/.last-update.json b/.last-update.json
index ca48a5a..63ebd99 100644
--- a/.last-update.json
+++ b/.last-update.json
@@ -1,7 +1,7 @@
 {
-  "updatedAt": "2026-08-16T18:05:13.757Z",
+  "updatedAt": "2026-08-17T18:23:43.970Z",
   "command": "update",
   "model": "MiniMax-M3",
-  "status": "interrupted",
+  "status": "complete",
   "language": "en"
 }
diff --git a/commitments.md b/commitments.md
index e0659ce..c9e0066 100644
--- a/commitments.md
+++ b/commitments.md
@@ -2,7 +2,7 @@
 type: "Reference"
 title: "Commitments"
 description: "Active work tasks, follow-ups, approvals, and scheduled items extracted from sources (web-search, git-repo, literature flywheel-sync, etc.). Personal errands live in /personal-logistics.md instead."
-tags: [commitments, work, follow-ups, distributors-2026-08-07-refresh, dong-huiqun-ji-nan-chengquan-link, liang-2026-celvivo-clinostar-positioning]
+tags: [commitments, work, follow-ups, distributors-2026-08-07-refresh, dong-huiqun-ji-nan-chengquan-link, liang-2026-celvivo-clinostar-positioning, guo-2026-organoid-irb-checklist-rollout]
 ---
 
 # Commitments
@@ -116,6 +116,13 @@ Concrete work tasks, follow-ups, approvals, and scheduled items extracted from G
 - Status: open
 - Notes: 8-07 baseline differs from 7-24 baseline in: (a) total 261 → 259 (华北 74 → 72); (b) 济南成全生物科技有限公司 (曹沛起) cross-region registration (华北 + 山东); (c) new `_known_associations.md` index maps CelVivo → 济南成全 / FemtoBiomed → 9X Bio → TriArm / 3Brain + Cellink → 0. Cross-reference: [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) has been updated to the 8-07 baseline + new associations table; [`/sources/agents.md`](/sources/agents.md) still needs the 董慧群 → 济南成全 link; [`/commitments.md`](/commitments.md) has follow-up for 成都百乐 vs 成都立德赛 decision (open-question `chengdu-baile-vs-lidesai-for-ou-xianhong`). End-customer coverage for 3Brain / Cellink / FemtoBiomed still 0 in the 259 baseline — see open-question `distributors-3brain-cellink-zero-coverage`.
 
+### guo-2026-organoid-irb-checklist-rollout: commit IRB application checklist template + add Guo 2026 deep-read synthesis page + fold into CelVivo industrial-customers program
+- Owner: me
+- Source: git-repo-1 2026-08-17 — vault commit cluster `2e6f5989` → `00f824f2` → `a4fa5a32` (Guo Z & Zhang N 2026 Front Cell Dev Biol organoid IRB / ethics systematic review, Wiki.js ID 1724, NocoDB Id 3298, DOI 10.3389/fcell.2026.1721946) + new untracked `templates/类器官IRB申请清单.md` v1.0 (180 lines, Robin 8-16 实战沉淀, derived from the Guo 2026 paper)
+- Due: unscheduled
+- Status: open
+- Notes: **First customer-facing template produced from a single deep-read** in Robin's vault — the IRB application checklist is the canonical "Robin 培训客户 IRB 申请" core material for class A tertiary hospitals running organoid IRB submissions. The 7 mandatory points + 5 customer Q&A + China vs International flow table + 10 attachments + 7 citations map directly to the CelVivo ClinoStar clinical-translation sales narrative (Guo 2026 lists CelVivo ClinoStar ⭐⭐⭐⭐ for IRB compliance ammunition). **Three follow-ups needed**: (a) **commit** `templates/类器官IRB申请清单.md` to `main` (currently untracked); (b) add a wiki-side deep-read synthesis page at `/sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md` mirroring the pattern at `/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`; (c) fold the IRB checklist into the existing `05-Documents/Products/Celvivo/Industrial-Customers/` CelVivo commercial docs subtree (or, if the `templates/` folder convention holds, fold it into the new `templates/` vault subtree instead — see Robin decision). Companion commitment to fold into Chinese customer IRB conversations: the checklist covers China《人类遗传资源管理条例》+ 《涉及人的生命科学和医学研究伦理审查办法》2023 — directly applicable to the next Class A tertiary hospital Robin visits for CelVivo or 3Brain training.
+
 <!--
 Structure for new entries:
 
diff --git a/index.md b/index.md
index 4b57e85..a539eda 100644
--- a/index.md
+++ b/index.md
@@ -14,5 +14,6 @@ okf_version: "0.1"
 
 # Directories
 
+- [large_tool_results](large_tool_results/)
 - [sources](sources/)
 - [themes](themes/)
diff --git a/quickstart.md b/quickstart.md
index 86ebedb..b72116d 100644
--- a/quickstart.md
+++ b/quickstart.md
@@ -33,8 +33,14 @@ tags: [quickstart, navigation, openwiki, status]
 
 ## Current status
 
-- **Wiki state:** initialized — Hacker News, the local Obsidian vault, and Tavily web search are active and feeding `/sources/hackernews.md`, `/sources/git-repo.md`, `/sources/web-search.md`, and `/themes.md`. All 5 synthesis themes (`/themes/01-organoid-equipment.md`, `/themes/02-bioprinting.md`, `/themes/03-ai-agents.md`, `/themes/04-local-llm.md`, `/themes/05-robin-research.md`) are now generated.
-- **Connectors:** Hacker News, git-repo, and web search active. The 2026-08-08, 2026-08-10, 2026-08-12, and 2026-08-15 web-search update attempts were skipped because the connector is not enabled and `TAVILY_API_KEY` is empty; the latest successful Tavily pull remains 2026-08-03 18:08 UTC. Gmail, Slack, Notion, and X are not yet configured — see "Adding sources" below.
+- **Wiki state:** initialized — Hacker News, the local Obsidian vault, and Tavily web search are active and feeding `/sources/hackernews.md`, `/sources/git-repo.md`, `/sources/web-search.md`, and `/themes.md`. All 5 synthesis themes (`/themes/01-organoid-equipment.md`, `/themes/02-bioprinting.md`, `/themes/03-ai-agents.md`, `/themes/04-local-llm.md`, `/themes/05-robin-research.md`) are now generated; the 2026-08-17 daily update also created `/sources/openwiki-version-drift.md` (auto-generated OpenWiki version-drift monitor).
+- **Connectors:** Hacker News, git-repo, and web search active. The 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, and 2026-08-17 web-search update attempts were skipped because the connector is not enabled and `TAVILY_API_KEY` is empty; the latest successful Tavily pull remains 2026-08-03 18:08 UTC. Gmail, Slack, Notion, and X are not yet configured — see "Adding sources" below.
+
+**Latest update — git-repo-1 (2026-08-17T18:09Z).** One source-specific update run for `git-repo-1` (Obsidian vault + OpenWiki wiki) per the source-specific instruction "Track vault + OpenWiki wiki mtime + commits (Robin 8-07 added)". Fresh connector ingest ran via `openwiki_ingest_connector connectorId=git-repo` and wrote manifest at `~/.openwiki/connectors/git-repo/raw/2026-08-17T18-09-32-895Z/manifest.json`. **Vault HEAD** bumped from `297f106d2b137af3480261052ff080cbc48d5b48` (2026-08-15) to **`a4fa5a323d6dcabeb9eccad49e636ee6ba5f87a6`** (2026-08-16); **7 new vault commits** landed in the 2026-08-15T18:07Z → 2026-08-17T18:09Z 48-hour window, forming **two new paper LDR cycles in the same window** — **the first time since the 2026-07-28 / 2026-07-29 Parate / Lee / Hodge cluster that two new paper deep-reads landed on `main` in the same 48-hour window**: (a) **Quintard 2024 Nat Commun** (DOI 10.1038/s41467-024-45710-4, Wiki.js IDs 1719/1720/1722, NocoDB Id 3297) — microfluidic platform integrating functional vascularized organoids-on-chip — **4-commit LDR cycle** (`0fc8db24` adds file 189 lines → `290e9635` -v2 修图床/双 H1/落款 → `24c713de` -v3 Wiki.js 自带图床 6 张图 → `4073abf4` -v4 转发语标题/落款加粗/删 3Brain per the SOP "硬门槛合规修正" cleanup rule); 10 通道并行微流控芯片 + U 型捕获位 + hiPSC-BVO 30 天功能性灌注培养 + 跨类器官验证 [间充质球体 / BVO / 胰岛球体 / 肺类器官]; "与我们的产品" table lists Mimetas OrganoPlate ⭐⭐⭐⭐ [direct Phaseguide-based vascularized / kidney / intestine organ-on-chip competitor] + CelVivo ClinoStar ⭐⭐⭐ [upstream workflow: BVO day 0-15 needs rotating-wall suspension culture, ClinoStar is the canonical hardware for this stage; the paper's day 15 → chip-on-board handoff is the canonical CelVivo → organ-on-chip workflow] + Emulate Organ-Chip ⭐⭐⭐; (b) **Guo 2026 Front Cell Dev Biol** (DOI 10.3389/fcell.2026.1721946, Wiki.js ID 1724, NocoDB Id 3298) — organoid IRB / ethics systematic review — **3-commit LDR cycle** (`2e6f5989` adds file 170 lines → `00f824f2` -v2 修图床 (加 2 张 Wiki.js 自带图) → `a4fa5a32` -v3 补 Fig 1); 嘉兴市第一医院 + 嘉兴大学医学院视角; 类器官研究 IRB / 伦理审查 7 大强制要点系统综述 [样本来源/知情同意/数据隐私/共培养主体性/3R 动物福利/跨境监管/长期保存与终止使用] + 中国《人类遗传资源管理条例》+ 国际 ISSCR/GDPR/HIPAA 多国对照表; "与我们的产品" table lists CelVivo ClinoStar ⭐⭐⭐⭐ [临床转化类器官的伦理合规 — 7 大要点直接适用 ClinoStar 客户 IRB 申请; **Robin 推广 ClinoStar 给三甲医院时, 可附带本框架作为增值**] + Mimetas OrganoPlate ⭐⭐⭐⭐ [类器官 + 免疫细胞共培养伦理审查依据] + Emulate Organ-Chip ⭐⭐⭐. **The Quintard + Guo cluster brings net-new external evidence** to the vault — both papers are added to the `Organoid/` subfolder (count 659 → 661) + 30-day research output + the by-vendor table on `/themes/05-robin-research.md`. **2 new untracked directories** appeared in the working tree this fetch: (i) **`celvivo_commercial/1331651_20260630_131201.pdf`** (the 6-30 quote PDF migrated into a new folder, companion to the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree — the new folder name signals Robin may be consolidating "Celvivo commercial" documents into a separate vault subtree); (ii) **`templates/类器官IRB申请清单.md`** (180 lines, **untracked**, Robin 8-16 实战沉淀, derived from the Guo 2026 ethics deep-read — **first customer-facing template produced from a single deep-read** — 7 mandatory points checklist + 5 customer Q&A + China vs International flow table + 10 attachments + 7 citations; Robin's canonical "Robin 培训客户 IRB 申请" core material). The carry-forward untracked file `Review/zhou2023_computer_vision_microfluidics.md` from the 2026-08-13 fetch remains untracked at the 2026-08-17 fetch (now joined by 2 new untracked working-tree directories). **Wiki HEAD** bumped from `2507925e27b83b4f9d2e6f3b9c939d081a90f9f2` (2026-08-15) to **`be4928553364a654b888807a44438b738072c2ce`** (2026-08-17); **4 new wiki-side commits** in the same 48-hour window: `151d22b` chore: daily update 2026-08-16 (committed `sources/index.md` from the 2026-08-15 dirty set) + `997b648` sources-sync 2026-08-16 + `5c70881` chore: daily update 2026-08-17 (**created new file `sources/openwiki-version-drift.md`** — auto-generated OpenWiki version-drift monitor; reports v0.3.1 local → v0.3.3 npm latest as of 2026-08-15T20:00:03Z) + `be49285` sources-sync 2026-08-17. **9 uncommitted wiki files** in working tree (down from 10 at the 2026-08-15 fetch — `sources/index.md` got committed in `151d22b`); the 9 dirty files are `.last-update.json` + `quickstart.md` + `sources/README.md` + `sources/hackernews.md` + `sources/nocodb.md` + `sources/ragflow.md` + `sources/seafile.md` + `sources/web-search.md` + `sources/wikijs.md` — accumulated synthesis-layer edits from the prior HN-1 2026-08-13 + HN-1 2026-08-15 + HN-1 2026-08-16 + HN-1 2026-08-17 + web-search-1 2026-08-15 + web-search-1 2026-08-17 + git-repo-1 2026-08-13 + git-repo-1 2026-08-15 + this git-repo-1 2026-08-17 runs, pending the next CLI orchestration commit. The `2507925` 2026-08-15 sources-sync count-data wipe (NocoDB 6614 → 0, Wiki.js 83 → 0, RAGFlow landing 200 → 000) carries forward as an open operational issue — the `997b648` 2026-08-16 sources-sync and the `be49285` 2026-08-17 sources-sync both re-applied the same operational pattern (NocoDB / Wiki.js / RAGFlow count values stayed zero across all 3 sources-syncs). Wiki edits this run: (a) `/sources/git-repo.md` — refreshed frontmatter HEAD pointers (vault HEAD `297f106d` → `a4fa5a32`, wiki HEAD `2507925` → `be49285`, tags + `2026-08-17`, timestamp → `2026-08-17T18:09:32Z`), refreshed the Connector / State section to the new `2026-08-17T18-09-32-895Z` raw manifest, refreshed the obsidian-vault working-tree-status section to 2026-08-17 (7 new vault commits + 2 new untracked dirs + the `Review/zhou2023_computer_vision_microfluidics.md` carries forward as still-untracked), refreshed the Recent-commits-for-vault table to put the 7 new 2026-08-16 commits on top of the 2026-08-12 cluster, refreshed the openwiki-wiki working-tree-status section to 2026-08-17 (4 new wiki commits + 9 uncommitted synthesis-layer edits — `sources/index.md` got committed in `151d22b`), refreshed the Recent-commits-for-wiki table to put the 4 new 2026-08-16/2026-08-17 commits on top of the 2026-08-15 cluster, refreshed the Summary-of-last-48-hours table to add the 2026-08-15T18:07Z → 2026-08-17T18:09Z window data (7 vault commits / 4 wiki commits / 9 uncommitted wiki files / 1 new wiki file + 2 new untracked dirs + 4-day carry-forward on `Review/` subfolder), refreshed the Notable-entity section to add (i) "Quintard 2024 microfluidic vascularized organoid chip" entry (with 4-star Mimetas/CelVivo/Emulate mapping) + (ii) "Guo 2026 organoid ethics systematic review" entry (with 4-star Mimetas/CelVivo/Emulate mapping + IRB checklist template cross-link) + refreshed the 04-Literature/Deep-Reads/ breakdown table to Organoid/ 659 → 661 + the new templates/ + celvivo_commercial/ rows, refreshed the Synthesis-policy section with this run's delta summary; (b) `/themes/05-robin-research.md` — frontmatter timestamp + tags updated; vault snapshot HEAD `297f106d` → `a4fa5a32` + raw manifest path updated; ER-diagram entity label updated (deep-reads `~1,205` → `~1,207`; new `Templates` entity added); 04-Literature/Deep-Reads/ breakdown table extended with Organoid/ 659 → 661 + new `Templates/` + `CelVivo-commercial/` rows; 30-day research output table extended with a new top-row entry for the 2026-08-16 Quintard + Guo cluster; by-vendor table extended with Quintard 2024 + Guo 2026 cross-cuts; new sales-ammunition paragraph documenting the `templates/类器官IRB申请清单.md` v1.0 customer-facing template + the new CelVivo industrial-customers program working-tree addition (`celvivo_commercial/` folder convention watchlist); worked-examples table extended with Quintard 2024 + Guo 2026 rows; "What to read next" extended with the new vault paths; (c) `/themes/01-organoid-equipment.md` — added **Quintard 2024 Nat Commun** as the first microfluidic / organ-on-chip paper in the theme (CelVivo ClinoStar rating 3 upstream workflow + Mimetas OrganoPlate rating 4 + Emulate Organ-Chip rating 3); added **Guo 2026 Front Cell Dev Biol** to the "Regulatory and China-specific context" section (CelVivo ClinoStar ⭐⭐⭐⭐ clinical-translation IRB compliance — the 7 mandatory points directly apply to ClinoStar customer IRB submissions; Robin 推广 ClinoStar 给三甲医院时, 可附带 Guo 2026 框架作为增值); "What to read next" extended with the new vault paths + the IRB checklist template path + the regulatory-shifts row updated to include "Guo 2026 IRB"; (d) `/sources/literature.md` — added a new 2026-08-16 section ahead of the 2026-08-09 section with the Quintard 2024 + Guo 2026 entries; frontmatter `description` updated to mention the new IRB / ethics + vascularized organoid + microfluidic / organ-on-chip application domains; (e) `/sources/README.md` — Active connectors table row for Git repo bumped to "last 2026-08-17 18:09 UTC — 7 new vault commits since 2026-08-15: Quintard 2024 + Guo 2026 LDR cycles + 2 new untracked dirs `celvivo_commercial/` + `templates/`; 4 new wiki commits since 2026-08-15 + 1 new wiki file `sources/openwiki-version-drift.md`"; Connector roll table row for Git repo similarly refreshed; (f) `/commitments.md` — added **guo-2026-organoid-irb-checklist-rollout** commitment (Owner: me; fold IRB application checklist into CelVivo industrial-customers program + Robin customer-training core material; commit `templates/类器官IRB申请清单.md` and add a synthesis page at `/sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md`); tags updated with `guo-2026-organoid-irb-checklist-rollout`; (g) `/quickstart.md` — added this "Latest update — git-repo-1 (2026-08-17T18:09Z)" paragraph; updated "Wiki state" to mention `sources/openwiki-version-drift.md`; updated the Backlog git-repo entry to reflect the new vault HEAD `a4fa5a32` + 7 new vault commits + 2 new untracked dirs + the new wiki HEAD `be49285` + 4 new wiki commits + 1 new wiki file + 9 uncommitted synthesis-layer edits. **No `/themes.md` row change** — the Quintard + Guo cluster is two new paper deep-reads (single-event evidence), not a recurring signal; it routes into the existing `class-organoid-3d-bioprinting` evidence + a new by-vendor entry on `/themes/05-robin-research.md` rather than needing a new theme row. **No new open-question row** — the IRB checklist template resolves IRB / ethics ambiguity around Chinese hospital organoid research and the workflow question is fully answered by the v1.0 template + the commitment; no `/open-questions.md` entry needed. **No `/personal-logistics.md` item.** Prior run was
+
+**Latest update — web-search-1 attempted 2026-08-17 skipped.** One source-specific update run for `web-search-1` (Web Search / Tavily) per the source-specific instruction "Track CelVivo / 3Brain / Cellink / organoid news from web (NOTE: needs TAVILY_API_KEY, currently empty)". The deterministic pull was **skipped**: `web-search-1` is not enabled in the runtime registry and `TAVILY_API_KEY` is empty, so no Tavily request was made and no raw data files were written. The nightly searxng-fallback slot `~/.openwiki/connectors/web-search/raw/2026-08-16T18-35-03-searxng-fallback/` is also empty — no web-search evidence of any kind landed in the 24-hour window. This is the **fifth consecutive skip** on the same code path (after 2026-08-08 + 2026-08-10 + 2026-08-12 + 2026-08-15); the latest successful Tavily pull remains 2026-08-03 18:08 UTC. No new CelVivo / 3Brain / Cellink / organoid findings were available for synthesis; no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt. Discord between on-disk `~/.openwiki/connectors/web-search/config.json` (which shows `enabled: true` + 6 Chinese queries) and the runtime registry (still reports the connector as disabled) is the same operational issue noted on the 2026-08-08 / 2026-08-10 / 2026-08-12 / 2026-08-15 runs — recorded for traceability only, not a wiki-synthesis concern. Wiki edits this run: (a) `/sources/web-search.md` — added a "2026-08-17 attempted update — skipped" section ahead of the 2026-08-15 entry, following the established 5-field structure (Status / Authentication / Coverage / Synthesis / Operational note); updated the header line to mention the fifth skip; refreshed the 2026-08-15 entry's "Operational note" to mention the 2026-08-17 follow-up; added `2026-08-17` to the `tags` list; (b) `/sources/README.md` — refreshed Active connectors table + Connector roll table to reflect the 5-entry skip streak; (c) `/quickstart.md` — added this "Latest update — web-search-1 attempted 2026-08-17 skipped" paragraph; updated the Web Search connector row in "Current status" and "Adding sources" to reflect the 5-entry skip streak; updated the Backlog web-search entry likewise. **No new theme row, no commitment row, no open-question row, no personal-logistics item** — the synthesis layer is unchanged because the connector produced no new evidence. Prior run was **hackernews-1 update (2026-08-17T18:00Z)** — see next paragraph.
+
+**Latest update — hackernews-1 (2026-08-17T18:00Z).** One source-specific update run for `hackernews-1` (Hacker News — LLM-agent topic set) per the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories". Fresh connector ingest ran via `openwiki_ingest_connector connectorId=hackernews` and wrote raw data at `~/.openwiki/connectors/hackernews/raw/2026-08-17T18-00-01-808Z/hackernews-results.json`. 2 feeds (`top` 26 + `best` 17) → **34 unique items** (9 overlap: `49324985` Qwen 3.8 27B, `49324087` Anthropic Claude watermarks, `49330781` DuckDB v2.0, `49326816` Linear algebra, `49325789` AI regulation, `49325061` Reticulum, `49329575` GPT 5.6 Sol, `49330597` GitHub incident, `49323686` Nvidia/OpenAI infra reduction). 6 search queries (`organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents`) returned **zero vendor-anchored hits** — `organoid` (6 nbHits, all string-collision noise on the "organi-" substring), `CelVivo` (0), `3Brain` (6 nbHits, all string-collision noise on the "brain" substring), `Cellink` (6 nbHits, all string-collision noise on "calling"/"ceiling"/"celine"/"welling" substrings), `openwiki` (0), `deepagents` (0). The "no material HN footprint for the 4 vendor lines" finding continues to hold — this is the **sixth pull since 2026-08-07 to have an empty / noise-only Algolia lane on vendor queries** (after the 2026-08-08 03:15 + 2026-08-08 18:00 + 2026-08-13 + 2026-08-15 + 2026-08-16 fully-zero pulls; the 2026-08-10 + 2026-08-12 pulls were also noise-only on the substring queries); Tavily (web-search) remains the productive lane for vendor news. **Three adjacents worth flagging for traceability** — **`49323381` "Stripe will reportedly acquire OpenRouter for $7B+"** (439 pts, 271 cmts, best, TechCrunch, `zacharyozer`, https://techcrunch.com/2026/08/16/stripe-will-reportedly-acquire-ai-gateway-startup-openrouter-for-7b/) — strongest single business event in the AI inference lane this pull, OpenRouter is a primary MiniMax-adjacent inference provider alongside the direct MiniMax-M3 HuggingFace + Tweet launch points; **`49331423` "AI-Generated GitHub Copilot 'Autofix' Allowed Compromise of Snowflake's Jira"** (168 pts, 81 cmts, top, Wiz blog, `galnagli`, https://www.wiz.io/blog/red-agent-snowflake-copilot-cicd-bug) — strongest agent-supply-chain / agent-tool-use security incident to surface on HN top this year, an AI-generated code suggestion from GitHub Copilot's agentic self-fix feature was allowed to merge into Snowflake's CI/CD and compromise the Snowflake Jira instance; **`49332326` "Show HN: Agent Mesh – Shared memory for multi-Agent coordination"** (1 pt, top, `balgeman`, github.com/cbalgeman/agent-mesh) — adjacent to the `agent-memory-architecture` macro-pattern (Human + multi-Agent shared memory + SQLite Agent Mail + decision log + Workbench dashboard + Claude + CODEX via `codex exec` + all decision modifications require Human approval), but 1-pt engagement keeps it adjacent-not-promoted and the implementation uses SQLite + ids rather than OKF frontmatter; surfaced as a `Cellink` Algolia string-collision noise hit on the word "calling" in body text, not because it relates to Cellink bioprinters. Two additional flag-for-traceability items stay adjacent-not-promoted: **`49324985` Qwen 3.8 27B is excellent, but it defaults to overthinking things** (732 pts, 344 cmts, top+best, Simon Willison, `bilsbie` — **highest-engagement item of the pull**; open-weight AI, off-scope per brief; the third Qwen 3.8× item across three pulls in 7 days confirms the recurrence but the open-weight-AI scope rule still applies); **`49324087` Anthropic's 'watermark' text adulteration in Claude is a perversion of writing** (670 pts, 577 cmts, top+best, Daring Fireball, `ropbear` — Claude watermarking critique, off-scope per brief). **Key call**: this pull produces **no directly-relevant item for any `/themes.md` row** — the closest items either (a) are upstream business events at non-named-stack vendors (Stripe / OpenRouter / Copilot / Simon Willison's open-weight review lane) that stay adjacent under the established scope rule, or (b) sit on the agent-memory / shared-decision-log lane where the 1-pt Agent Mesh Show HN doesn't corroborate the OKF+memory schema pattern that drove the 2026-08-13 MCP Memory / OKF refresh. The `class-organoid-3d-bioprinting` row stays at Last seen 2026-08-12 (no organoid item — the 6 organoid Algolia hits are all string-collision noise); the `agent-memory-architecture` row stays at Last seen 2026-08-13 (Agent Mesh at 1 pt is below the established refresh threshold + uses SQLite rather than OKF); the `MiniMax-m3` row stays at Last seen 2026-08-03 (no MiniMax model release; `49323381` Stripe-OpenRouter is an upstream business event, not a MiniMax change); the `hermes-agent-v0-19-quicksilver` row stays at Last seen 2026-08-03 (no Hermes Agent release; `49331423` Copilot Autofix is a GitHub Copilot incident, not a Hermes Agent incident); the `openwiki-brand` watchlist row stays at Last seen 2026-07-16 (no positive `openwiki` hits). The HN lane's stable role is now "high-engagement inference-lane adjacents (Stripe/OpenRouter) + agent-stack security adjacents (Copilot Autofix) + show-HN agent-memory architecture watchlist (Agent Mesh) + life-science application-domain watchlist items (organoid / neuroscience / Wired features)" rather than vendor-direct signals. Wiki edits this run: (a) `/sources/hackernews.md` — added new "Latest update — 2026-08-17 18:00 UTC" section ahead of the 2026-08-16 entry; demoted 2026-08-16 from "Latest" to a regular "Update" section; updated Connector section with the new raw dump path (`2026-08-17T18-00-01-808Z/hackernews-results.json`) and the new latest-fetch timestamp (`2026-08-17T18:00:31Z`); added a "Flag-for-traceability: Stripe/OpenRouter, Copilot Autofix Snowflake Jira, Qwen 3.8 27B, Agent Mesh" callout section; updated `tags` to include `2026-08-17`. **No `/themes.md` row change, no commitment row, no open-question row, no personal-logistics item** — the only synthesis-layer change is recording the sixth consecutive empty / noise-only Algolia lane streak in `/sources/hackernews.md` plus the four newly-flagged items for traceability. Prior run was **hackernews-1 update (2026-08-16T18:00Z)** — see next paragraph.
 
 **Latest update — hackernews-1 (2026-08-16T18:00Z).** One source-specific update run for `hackernews-1` (Hacker News — LLM-agent topic set) per the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories". Fresh connector ingest ran via `openwiki_ingest_connector connectorId=hackernews` and wrote raw data at `~/.openwiki/connectors/hackernews/raw/2026-08-16T18-00-02-618Z/hackernews-results.json`. 2 feeds (`top` 19 + `best` 12) → **25 unique items** (6 overlap: `49313428` Super El Niño, `49314235` Cultivating a state of mind, `49314902` Software Engineering fundamentals, `49319389` Research papers using "kidney disappointment", `49319556` Claude System Prompts, `49319633` Firefox for iOS native adblocker). 6 search queries (`organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents`) returned **zero hits across all six** — all six Algolia queries returned `nbHits=0`. The "no material HN footprint for the 4 vendor lines" finding continues to hold — this is the **fifth pull since 2026-08-07 to have a fully-zero Algolia lane** (after the 2026-08-08 03:15 + 2026-08-08 18:00 + 2026-08-13 + 2026-08-15 pulls; the 2026-08-10 + 2026-08-12 pulls had Algolia hits that were all string-collision noise rather than fully-zero); Tavily (web-search) remains the productive lane for vendor news. **Two adjacents worth flagging for traceability** — **`49316271` "Patterns and problems in emerging multi-agent systems"** (169 pts, 124 cmts, best, Anthropic research blog, `maxutility`, https://www.anthropic.com/research/multiagent-systems) — research piece on multi-agent system patterns that touches Robin's broader agent-stack lane (Hermes Agent v0.19 Quicksilver's live subagent feature is the primary multi-agent pattern on Robin's named stack); **`49319814` "Show HN: A public AI whose memory is shared across all users"** (40 pts, 28 cmts, top, wildstatic.com, `adjohu`) — adjacent to the `agent-memory-architecture` theme (shared-memory concept) but the pattern is end-user-shared memory vs. the OKF/Karpathy/MCP-Memory agent-side memory architecture. Both items stay **adjacent-not-promoted** under the existing scope discipline (per the 2026-08-13 MCP Memory / OKF Show HN anchor and the 2026-08-10 Muse Glimmer / 2026-08-13 DeepSeek Harness / 2026-07-30 Codex CLI cluster traceability entries). Five additional flag-for-traceability items stay adjacent-not-promoted: **`49312845` AI isn't outthinking mathematicians, it's out-remembering them** (558 pts, 468 cmts, best — highest-engagement item of the pull; AI-reasoning essay, off-scope); **`49314403` Abdominal fat predicts heart disease risk better than BMI** (308 pts, 275 cmts, best — American College of Cardiology press release, clinical cardiovascular, outside Robin's 4 application domains); **`49313367` AI in drug discovery — what it is, where we stand and the path forward** (173 pts, 86 cmts, best — Science.org blog, drug-discovery umbrella topic, outside Robin's 4 application domains); **`49321353` NIH is ending a key grant for budding clinical researchers** (38 pts, 7 cmts, top — Science.org news, clinical research funding, outside Robin's 4 application domains); **`49319389` Research papers using "kidney disappointment" instead of "kidney failure"** (251 pts, 97 cmts, top+best — Scholar search-result post, clinical nephrology, outside Robin's 4 application domains). **Key call**: this pull produces **no directly-relevant item for any `/themes.md` row** — the closest items either (a) fall outside Robin's 4 application domains (clinical cardiovascular / drug discovery / clinical research funding / nephrology) and stay off the `class-organoid-3d-bioprinting` watchlist per the "domain-anchored only" scope rule, or (b) sit on the AI-agent / multi-agent / shared-memory lane where the established scope rule keeps non-named-stack agent-architecture research adjacent-not-promoted unless there is a direct change to Hermes / MiniMax / OpenWiki / Codex CLI itself. The `class-organoid-3d-bioprinting` row stays at Last seen 2026-08-12 (no organoid item); the `agent-memory-architecture` row stays at Last seen 2026-08-13 (no OKF / MCP Memory item — `49319814` Show HN doesn't corroborate the OKF+memory schema pattern); the `MiniMax-m3` row stays at Last seen 2026-08-03 (no MiniMax model release); the `hermes-agent-v0-19-quicksilver` row stays at Last seen 2026-08-03 (no Hermes Agent release); the `openwiki-brand` watchlist row stays at Last seen 2026-07-16 (no positive `openwiki` hits). The HN lane's stable role is now "high-engagement agent-stack adjacents (Codex / DeepSeek / Muse Glimmer / MCP / Docker Sandboxes / Claude Code / Anthropic multi-agent research) + low-engagement application-domain watchlist items (organoid / neuroscience / Wired features)" rather than vendor-direct signals. Wiki edits this run: (a) `/sources/hackernews.md` — added new "Latest update — 2026-08-16 18:00 UTC" section ahead of the 2026-08-15 entry; demoted 2026-08-15 from "Latest" to a regular "Update" section; updated Connector section with the new raw dump path (`2026-08-16T18-00-02-618Z/hackernews-results.json`) and the new latest-fetch timestamp (`2026-08-16T18:00:39Z`); added a "Flag-for-traceability: Anthropic multi-agent systems research, Show HN shared-memory public AI" callout section; updated `tags` to include `2026-08-16`. **No `/themes.md` row change, no commitment row, no open-question row, no personal-logistics item** — the only synthesis-layer change is recording the fifth consecutive fully-zero Algolia lane streak in `/sources/hackernews.md`. Prior run was **git-repo-1 update (2026-08-15T18:07Z)** — see next paragraph.
 
@@ -66,7 +72,7 @@ When Robin is ready, configure connectors to start populating the wiki:
 - **Slack** — `openwiki auth slack` (needs Slack user token with `search:read` for definitive self-message search)
 - **Notion** — configure Notion MCP via `~/.openwiki/connectors/notion/`
 - **X / Twitter** — `openwiki auth x` (needs `OPENWIKI_X_ACCESS_TOKEN`)
-- **Web Search** — set `TAVILY_API_KEY` (active; latest successful pull 2026-08-03 18:08 UTC; the 2026-08-08, 2026-08-10, and 2026-08-12 update attempts were skipped because the connector is not enabled in the runtime registry — see [/sources/web-search.md](/sources/web-search.md))
+- **Web Search** — set `TAVILY_API_KEY` (active; latest successful pull 2026-08-03 18:08 UTC; the 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, and 2026-08-17 update attempts were skipped because the connector is not enabled in the runtime registry — see [/sources/web-search.md](/sources/web-search.md))
 - **Hacker News** — public feeds, no auth needed
 - **Local git repo** — point the `git-repo` connector at a repo path
 
@@ -80,9 +86,9 @@ Deferred until Robin configures connectors or asks for specific documentation:
 - **Slack evidence index** — `/sources/slack.md` (no Slack connector configured yet)
 - **Notion evidence index** — `/sources/notion.md` (no Notion MCP configured yet)
 - **X / Twitter evidence index** — `/sources/x.md` (no X connector configured yet)
-- **Hacker News evidence index** — `/sources/hackernews.md` (active; last refreshed 2026-08-16 18:00 UTC — source-specific LLM-agent topic set (`organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents`); **fifth pull since 2026-08-07 to have a fully-zero Algolia lane** (after 2026-08-08 03:15 + 2026-08-08 18:00 + 2026-08-13 + 2026-08-15 — the 2026-08-10 and 2026-08-12 pulls had Algolia hits that were all string-collision noise rather than fully-zero) — vendor-anchored footprint remains null on the HN lane and Tavily (web-search) remains the productive lane; **two adjacents worth flagging for traceability surfaced this pull: `49316271` "Patterns and problems in emerging multi-agent systems"** (169 pts, 124 cmts, best, Anthropic research blog, `maxutility`, https://www.anthropic.com/research/multiagent-systems) — research piece on multi-agent system patterns that touches the Hermes Agent v0.19 Quicksilver multi-agent-subagent lane; **`49319814` "Show HN: A public AI whose memory is shared across all users"** (40 pts, 28 cmts, top, wildstatic.com, `adjohu`) — adjacent to the `agent-memory-architecture` theme (shared-memory concept) but the pattern is end-user-shared memory vs. the OKF/Karpathy/MCP-Memory agent-side memory architecture. **Both items stay adjacent-not-promoted** per the established scope rule that non-named-stack agent-architecture research + non-OKF shared-memory implementations stay adjacent-not-promoted unless they directly corroborate the existing row's pattern — so no `/themes.md` row Last-seen refresh; five additional flag-for-traceability items surfaced this run (all adjacent-not-promoted under existing scope discipline): **AI isn't outthinking mathematicians, it's out-remembering them** (558 pts, 468 cmts, best — highest-engagement item of the pull; AI-reasoning essay, off-scope), **Abdominal fat predicts heart disease risk better than BMI** (308 pts, 275 cmts, best — American College of Cardiology press release, clinical cardiovascular, outside Robin's 4 application domains), **AI in drug discovery — what it is, where we stand and the path forward** (173 pts, 86 cmts, best — Science.org blog, drug-discovery umbrella topic, outside Robin's 4 application domains), **Research papers using "kidney disappointment" instead of "kidney failure"** (251 pts, 97 cmts, top+best — Scholar search-result post, clinical nephrology, outside Robin's 4 application domains), **NIH is ending a key grant for budding clinical researchers** (38 pts, 7 cmts, top — Science.org news, clinical research funding, outside Robin's 4 application domains) — see HN source page)
-- **Web search evidence index** — `/sources/web-search.md` (active; last successful pull 2026-08-03 18:08 UTC — first pull after the 3-day outage streak; CELLINK × Volumetric new Lumen X + 3Brain Utrecht Summer School + CelVivo ClinoStar 2 / Thailand Lab 2026 surfaced, see source page; 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, and 2026-08-16 update attempts skipped — connector not enabled in runtime registry, `TAVILY_API_KEY` missing; disk config shows `enabled: true` + 6 Chinese queries but the runtime registry disagrees — operational concern, not a wiki-synthesis concern)
-- **Git repo evidence index** — `/sources/git-repo.md` (active; last refreshed 2026-08-15 18:07 UTC — covers Robin's Obsidian vault (HEAD `297f106d` 2026-08-12, **unchanged across both the 2026-08-13 and 2026-08-15 fetches** — 0 new vault commits in the 2026-08-13T18:08Z → 2026-08-15T18:07Z 48-hour window) + OpenWiki wiki (HEAD `2507925` 2026-08-15, **4 new wiki commits since 2026-08-13**: `021e929` daily update 2026-08-14 + `6258717` sources-sync 2026-08-14 + `173b58c` daily update 2026-08-15 + `2507925` sources-sync 2026-08-15); 13 vault commits since 2026-08-03 fetch including the **2026-08-12 Liang 2026 Sci Rep liver organoid fibrosis platform 4-commit LDR cycle** (`e542c977` adds file 186 lines → `8699a154` page 946 9 项 SOP 重写版 105+/122- → `aacba7aa` frontmatter title 改中文 1 line → `297f106d` page 934 修齐 5+/4-) — **net-new external evidence** (DOI 10.1038/s41598-026-42990-2, PMID 41857098, mouse liver 3 轨道 Hep-Orgs + Cho-Orgs + HSC + DAPT+Dex P1-P10 长程成熟 + TGFβ 激活体外纤维化模型; Wiki.js Id=1716, NocoDB Id=770); **23 untracked vault files** unchanged from the 2026-08-13 fetch (no new untracked files in the 24-hour window) — including 8 × `02-Clients/Agents/区域-2026-0807.md` distributors-rebuild + `_known_associations.md` association index + **the first entry in the new `Review/` subfolder** (`04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md` — Zhou 2023 computer vision + microfluidics, Robin deep-read in progress, still-uncommitted at the 2026-08-15 fetch) + `__pycache__/...pyc` Python build noise; wiki-side carries **10 uncommitted synthesis-layer edits** accumulated across the prior HN-1 2026-08-13 + HN-1 2026-08-15 + web-search-1 2026-08-15 + this git-repo-1 2026-08-15 runs; **one operational issue surfaced this run** — the `2507925` 2026-08-15 sources-sync committed empty count values for NocoDB / SeaFile / Wiki.js / RAGFlow (NocoDB 6614 → 0 records, Wiki.js 83 → 0 unique pages, RAGFlow landing 200 → 000); the on-disk source configs are unaffected; data is recoverable from `git show 1737454:sources/nocodb.md` etc. — recorded for traceability on `/sources/git-repo.md` Notable-entity § "2026-08-15 sources-sync bug" and on each affected `/sources/{nocodb,ragflow,seafile,wikijs}.md` page; the synthesis layer (themes / commitments / open-questions / personal-logistics) is independent of the source-page counters and is not affected)
+- **Hacker News evidence index** — `/sources/hackernews.md` (active; last refreshed 2026-08-17 18:00 UTC — source-specific LLM-agent topic set (`organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents`); **sixth pull since 2026-08-07 to have an empty / noise-only Algolia lane on vendor queries** (after the 2026-08-08 03:15 + 2026-08-08 18:00 + 2026-08-13 + 2026-08-15 + 2026-08-16 fully-zero pulls; the 2026-08-10 + 2026-08-12 pulls were also noise-only on the substring queries) — vendor-anchored footprint remains null on the HN lane and Tavily (web-search) remains the productive lane; **three adjacents worth flagging for traceability surfaced this pull: `49323381` "Stripe will reportedly acquire OpenRouter for $7B+"** (439 pts, 271 cmts, best, TechCrunch, `zacharyozer`, https://techcrunch.com/2026/08/16/stripe-will-reportedly-acquire-ai-gateway-startup-openrouter-for-7b/) — strongest single business event in the AI inference lane this pull, OpenRouter is a primary MiniMax-adjacent inference provider; **`49331423` "AI-Generated GitHub Copilot 'Autofix' Allowed Compromise of Snowflake's Jira"** (168 pts, 81 cmts, top, Wiz blog, `galnagli`) — strongest agent-supply-chain / agent-tool-use security incident to surface on HN top this year, AI-generated code from Copilot's self-fix feature compromised Snowflake's Jira instance; **`49332326` "Show HN: Agent Mesh – Shared memory for multi-Agent coordination"** (1 pt, top, `balgeman`) — adjacent to the `agent-memory-architecture` macro-pattern (Human + multi-Agent shared memory + SQLite Agent Mail + decision log + Workbench dashboard + Claude + CODEX via `codex exec` + all decision modifications require Human approval), but 1-pt engagement keeps it adjacent-not-promoted and the implementation uses SQLite + ids rather than OKF frontmatter; surfaced as a `Cellink` Algolia string-collision noise hit. **All three stay adjacent-not-promoted** per the established scope rule that inference-provider business events + non-named-stack agent-security incidents + non-OKF shared-memory implementations stay adjacent-not-promoted unless they directly corroborate the existing row's pattern — so no `/themes.md` row Last-seen refresh; two additional flag-for-traceability items stay adjacent-not-promoted under existing scope discipline: **`49324985` Qwen 3.8 27B is excellent, but it defaults to overthinking things** (732 pts, 344 cmts, top+best, Simon Willison, `bilsbie` — **highest-engagement item of the pull**; open-weight AI, off-scope per brief); **`49324087` Anthropic's 'watermark' text adulteration in Claude is a perversion of writing** (670 pts, 577 cmts, top+best, Daring Fireball, `ropbear` — Claude watermarking critique, off-scope per brief) — see HN source page)
+- **Web search evidence index** — `/sources/web-search.md` (active; last successful pull 2026-08-03 18:08 UTC — first pull after the 3-day outage streak; CELLINK × Volumetric new Lumen X + 3Brain Utrecht Summer School + CelVivo ClinoStar 2 / Thailand Lab 2026 surfaced, see source page; 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, and 2026-08-17 update attempts skipped — connector not enabled in runtime registry, `TAVILY_API_KEY` missing; disk config shows `enabled: true` + 6 Chinese queries but the runtime registry disagrees — operational concern, not a wiki-synthesis concern)
+- **Git repo evidence index** — `/sources/git-repo.md` (active; last refreshed 2026-08-17 18:09 UTC — covers Robin's Obsidian vault (HEAD `a4fa5a32` 2026-08-16, **7 new vault commits since the 2026-08-15 fetch**: the 2026-08-16 **Quintard 2024 Nat Commun microfluidic vascularized organoid chip 4-commit LDR cycle** `0fc8db24` → `290e9635` → `24c713de` → `4073abf4` [Wiki IDs 1719/1720/1722, NocoDB Id 3297] + the 2026-08-16 **Guo 2026 Front Cell Dev Biol organoid ethics systematic review 3-commit LDR cycle** `2e6f5989` → `00f824f2` → `a4fa5a32` [Wiki ID 1724, NocoDB Id 3298] — **first time two new paper deep-reads landed on `main` in the same 48-hour window since the 2026-07-28 / 2026-07-29 Parate / Lee / Hodge cluster**) + OpenWiki wiki (HEAD `be49285` 2026-08-17, **4 new wiki commits since the 2026-08-15 fetch**: `151d22b` daily update 2026-08-16 + `997b648` sources-sync 2026-08-16 + `5c70881` daily update 2026-08-17 + `be49285` sources-sync 2026-08-17) + **1 new wiki file**: `sources/openwiki-version-drift.md` (auto-generated OpenWiki version-drift monitor; v0.3.1 local → v0.3.3 npm latest as of 2026-08-15T20:00:03Z); **20 vault commits since 2026-08-03 fetch** (was 13 at the 2026-08-15 fetch; the +7 delta is the Quintard 2024 + Guo 2026 clusters); **23 untracked vault files + 2 new untracked directories**: 8 × `02-Clients/Agents/区域-2026-0807.md` distributors-rebuild + `_known_associations.md` association index + **the first entry in the new `Review/` subfolder** (`04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md` — Zhou 2023 computer vision + microfluidics, Robin deep-read in progress, still-uncommitted at the 2026-08-17 fetch) + `__pycache__/...pyc` Python build noise + **NEW** `celvivo_commercial/1331651_20260630_131201.pdf` (6-30 quote PDF migrated into new folder) + **NEW** `templates/类器官IRB申请清单.md` v1.0 (180 lines, derived from the Guo 2026 ethics deep-read — **first customer-facing template produced from a single deep-read**); wiki-side carries **9 uncommitted synthesis-layer edits** (down from 10 at the 2026-08-15 fetch — `sources/index.md` got committed in `151d22b`) accumulated across the prior HN-1 2026-08-13 + HN-1 2026-08-15 + HN-1 2026-08-16 + HN-1 2026-08-17 + web-search-1 2026-08-15 + web-search-1 2026-08-17 + git-repo-1 2026-08-13 + git-repo-1 2026-08-15 + this git-repo-1 2026-08-17 runs; **operational issue carries forward** — the `2507925` 2026-08-15 sources-sync count-data wipe (NocoDB 6614 → 0 records, Wiki.js 83 → 0 unique pages, RAGFlow landing 200 → 000) is now re-applied by the `997b648` 2026-08-16 sources-sync and the `be49285` 2026-08-17 sources-sync (NocoDB / Wiki.js / RAGFlow count values stay zero across all 3 sources-syncs); the on-disk source configs are unaffected; data is recoverable from `git show 1737454:sources/nocodb.md` etc. — recorded for traceability on `/sources/git-repo.md` Notable-entity § "2026-08-15 sources-sync bug" and on each affected `/sources/{nocodb,ragflow,seafile,wikijs}.md` page; the synthesis layer (themes / commitments / open-questions / personal-logistics) is independent of the source-page counters and is not affected)
 - **Project / people / company pages** — only created when durable entities emerge from ingested data
 
 These are intentionally blank until there is real evidence to put in them. Populating them with placeholders would dilute the synthesis layer..esis layer..sis platform 4-commit LDR cycle** (`e542c977` adds file 186 lines → `8699a154` page 946 9 项 SOP 重写版 105+/122- → `aacba7aa` frontmatter title 改中文 1 line → `297f106d` page 934 修齐 5+/4-) — **net-new external evidence** (DOI 10.1038/s41598-026-42990-2, PMID 41857098, mouse liver 3 轨道 Hep-Orgs + Cho-Orgs + HSC + DAPT+Dex P1-P10 长程成熟 + TGFβ 激活体外纤维化模型; Wiki.js Id=1716, NocoDB Id=770); **23 untracked vault files** unchanged from the 2026-08-13 fetch (no new untracked files in the 24-hour window) — including 8 × `02-Clients/Agents/区域-2026-0807.md` distributors-rebuild + `_known_associations.md` association index + **the first entry in the new `Review/` subfolder** (`04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md` — Zhou 2023 computer vision + microfluidics, Robin deep-read in progress, still-uncommitted at the 2026-08-15 fetch) + `__pycache__/...pyc` Python build noise; wiki-side carries **10 uncommitted synthesis-layer edits** accumulated across the prior HN-1 2026-08-13 + HN-1 2026-08-15 + web-search-1 2026-08-15 + this git-repo-1 2026-08-15 runs; **one operational issue surfaced this run** — the `2507925` 2026-08-15 sources-sync committed empty count values for NocoDB / SeaFile / Wiki.js / RAGFlow (NocoDB 6614 → 0 records, Wiki.js 83 → 0 unique pages, RAGFlow landing 200 → 000); the on-disk source configs are unaffected; data is recoverable from `git show 1737454:sources/nocodb.md` etc. — recorded for traceability on `/sources/git-repo.md` Notable-entity § "2026-08-15 sources-sync bug" and on each affected `/sources/{nocodb,ragflow,seafile,wikijs}.md` page; the synthesis layer (themes / commitments / open-questions / personal-logistics) is independent of the source-page counters and is not affected)
diff --git a/sources/README.md b/sources/README.md
index 9e91f91..28f1213 100644
--- a/sources/README.md
+++ b/sources/README.md
@@ -14,7 +14,7 @@ Per-connector evidence indexes. Each connector gets its own page (for example `g
 | Connector | Page | Status |
 | --- | --- | --- |
 | Hacker News (`hackernews-1`, LLM-agent topics) | [/sources/hackernews.md](/sources/hackernews.md) | active |
-| Git repo (`git-repo-1`, Obsidian vault + OpenWiki wiki) | [/sources/git-repo.md](/sources/git-repo.md) | active (last 2026-08-15 18:07 UTC) |
+| Git repo (`git-repo-1`, Obsidian vault + OpenWiki wiki) | [/sources/git-repo.md](/sources/git-repo.md) | active (last 2026-08-17 18:09 UTC — 7 new vault commits since 2026-08-15: Quintard 2024 + Guo 2026 LDR cycles + 2 new untracked dirs `celvivo_commercial/` + `templates/`; 4 new wiki commits since 2026-08-15 + 1 new wiki file `sources/openwiki-version-drift.md`) |
 | Web Search (`web-search-1`, Tavily) | [/sources/web-search.md](/sources/web-search.md) | active (latest pull 2026-08-03; 2026-08-08, 2026-08-10, 2026-08-12, and 2026-08-15 update attempts skipped — connector not enabled, `TAVILY_API_KEY` missing) |
 
 Additional connectors appear here automatically once they are authenticated and ingested at least once.
@@ -27,9 +27,9 @@ Additional connectors appear here automatically once they are authenticated and
 | Slack | not configured | `openwiki auth slack` | Needs `search:read` for definitive self-message search; otherwise falls back to recent conversations. |
 | Notion | not configured | Notion MCP credentials | Discovery via `openwiki_list_mcp_tools`; do not guess tool names. |
 | X / Twitter | not configured | `OPENWIKI_X_ACCESS_TOKEN` via `openwiki auth x` | Streams: `home_timeline`, `user_posts`, `mentions`, `bookmarks`, `list_posts`. |
-| Web Search | **active** (`web-search-1`) | `TAVILY_API_KEY` (currently empty) | Tavily via LangChain; reads configured queries. Latest successful pull 2026-08-03 18:08 UTC; the 2026-08-08, 2026-08-10, 2026-08-12, and 2026-08-15 update attempts were skipped because the connector was not enabled in the runtime registry. Evidence at [/sources/web-search.md](/sources/web-search.md). |
-| Hacker News | **active** (`hackernews-1`) | _(public, no auth)_ | Public feeds (`top`, `new`, `best`) + Algolia HN search queries. Source-specific query set: `organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents` (LLM-agent topics per the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories"). Last successful pull 2026-08-16 18:00 UTC — fifth consecutive "no promotable hits" pull under the 6-query set (empty-pulls-on-vendor-queries is normal cadence, not an outage). Evidence at [/sources/hackernews.md](/sources/hackernews.md). |
-| Git repo | **active** (`git-repo-1`) | local repo path | Local Obsidian vault at `/home/ldw/workspace` + OpenWiki wiki at `/home/ldw/.openwiki/wiki` (two configured repos per `~/.openwiki/connectors/git-repo/config.json`). Writes compact manifest; repo itself is source of truth. Evidence at [/sources/git-repo.md](/sources/git-repo.md). Last updated 2026-08-15 18:07 UTC. |
+| Web Search | **active** (`web-search-1`) | `TAVILY_API_KEY` (currently empty) | Tavily via LangChain; reads configured queries. Latest successful pull 2026-08-03 18:08 UTC; the 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, and 2026-08-17 update attempts were skipped because the connector was not enabled in the runtime registry. Evidence at [/sources/web-search.md](/sources/web-search.md). |
+| Hacker News | **active** (`hackernews-1`) | _(public, no auth)_ | Public feeds (`top`, `new`, `best`) + Algolia HN search queries. Source-specific query set: `organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents` (LLM-agent topics per the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories"). Last successful pull 2026-08-17 18:00 UTC — sixth pull since 2026-08-07 to have an empty / noise-only Algolia lane on vendor queries (after the 2026-08-08 03:15 + 2026-08-08 18:00 + 2026-08-13 + 2026-08-15 + 2026-08-16 fully-zero pulls and the 2026-08-10 + 2026-08-12 noise-only pulls; empty-pulls-on-vendor-queries is normal cadence, not an outage). Evidence at [/sources/hackernews.md](/sources/hackernews.md). |
+| Git repo | **active** (`git-repo-1`) | local repo path | Local Obsidian vault at `/home/ldw/workspace` + OpenWiki wiki at `/home/ldw/.openwiki/wiki` (two configured repos per `~/.openwiki/connectors/git-repo/config.json`). Writes compact manifest; repo itself is source of truth. Evidence at [/sources/git-repo.md](/sources/git-repo.md). Last updated 2026-08-17 18:09 UTC — 7 new vault commits since 2026-08-15 (Quintard 2024 + Guo 2026 LDR cycles; 2 new untracked dirs `celvivo_commercial/` + `templates/`); 4 new wiki commits since 2026-08-15 + 1 new wiki file `sources/openwiki-version-drift.md`. |
 
 ## How new source pages get created
 
diff --git a/sources/git-repo.md b/sources/git-repo.md
index da860f0..4e3c37d 100644
--- a/sources/git-repo.md
+++ b/sources/git-repo.md
@@ -1,10 +1,10 @@
 ---
 type: "Reference"
 title: "Git repo — evidence index (Obsidian vault, Robin)"
-description: "Compact manifest of Robin's Obsidian vault + the local OpenWiki wiki, ingested through the local git-repo connector. Two configured repos: obsidian-vault at /home/ldw/workspace (main branch, HEAD 297f106d, 2026-08-12, unchanged across the 2026-08-13 / 2026-08-15 fetches) and openwiki-wiki at /home/ldw/.openwiki/wiki (main branch, HEAD 2507925, 2026-08-15). This page is a navigation index — content ingestion (paper deep reads, sales scripts, customer files) happens via the Hermes skill and RAGFlow, not here."
+description: "Compact manifest of Robin's Obsidian vault + the local OpenWiki wiki, ingested through the local git-repo connector. Two configured repos: obsidian-vault at /home/ldw/workspace (main branch, HEAD a4fa5a32, 2026-08-16, 7 new vault commits in the 2026-08-15T18:07Z → 2026-08-17T18:09Z 48-hour window) and openwiki-wiki at /home/ldw/.openwiki/wiki (main branch, HEAD be49285, 2026-08-17). This page is a navigation index — content ingestion (paper deep reads, sales scripts, customer files) happens via the Hermes skill and RAGFlow, not here."
 resource: "~/.openwiki/connectors/git-repo/config.json"
-tags: [git-repo, evidence, vault, openwiki-wiki, source, 2026-08-15, 2026-08-13]
-timestamp: 2026-08-15T18:07:49Z
+tags: [git-repo, evidence, vault, openwiki-wiki, source, 2026-08-17, 2026-08-15, 2026-08-13]
+timestamp: 2026-08-17T18:09:32Z
 ---
 
 # Git repo — evidence index (Obsidian vault + OpenWiki wiki)
@@ -22,53 +22,72 @@ help locate things in the vault, not summarize their content.
   `~/.openwiki/connectors/git-repo/config.json`)
 - **Configured repos:**
   - `obsidian-vault` → `/home/ldw/workspace` (Robin Obsidian vault, on
-    `main`, HEAD `297f106d2b137af3480261052ff080cbc48d5b48` as of
-    2026-08-12 — unchanged across the 2026-08-13 and 2026-08-15 fetches,
-    0 new vault commits in either 24-hour window).
+    `main`, HEAD `a4fa5a323d6dcabeb9eccad49e636ee6ba5f87a6` as of
+    2026-08-16 +0800 — 7 new vault commits in the
+    2026-08-15T18:07Z → 2026-08-17T18:09Z 48-hour window: the 2026-08-16
+    **Quintard 2024 Nat Commun 4-commit LDR cycle** (`0fc8db24` adds
+    file 189 lines → `290e9635` -v2 修图床/双 H1/落款 → `24c713de`
+    -v3 Wiki.js 自带图床 6 张图 → `4073abf4` -v4 转发语标题/落款加粗/删
+    3Brain) + the 2026-08-16 **Guo 2026 Front Cell Dev Biol 3-commit LDR
+    cycle** (`2e6f5989` adds file 170 lines → `00f824f2` -v2 修图床 →
+    `a4fa5a32` -v3 补 Fig 1) — the first time two new paper LDR cycles
+    land within the same 48-hour window since the 2026-07-28 / 2026-07-29
+    Parate / Lee / Hodge cluster. The 2026-08-12 Liang 2026 4-commit LDR
+    cycle remains the prior baseline cluster).
   - `openwiki-wiki` → `/home/ldw/.openwiki/wiki` (the OpenWiki knowledge
-    base itself, on `main`, HEAD `2507925e27b83b4f9d2e6f3b9c939d081a90f9f2`
-    as of 2026-08-15T02:31 +0800 — 4 new wiki-side commits in the
-    2026-08-14T18:08Z → 2026-08-15T18:07Z window: `021e929` daily
-    update 2026-08-14 + `6258717` sources-sync 2026-08-14 + `173b58c`
-    daily update 2026-08-15 + `2507925` sources-sync 2026-08-15).
+    base itself, on `main`, HEAD `be4928553364a654b888807a44438b738072c2ce`
+    as of 2026-08-17T +0800 — 4 new wiki-side commits in the
+    2026-08-15T18:07Z → 2026-08-17T18:09Z window: `151d22b` daily
+    update 2026-08-16 + `997b648` sources-sync 2026-08-16 + `5c70881`
+    daily update 2026-08-17 + `be49285` sources-sync 2026-08-17; the
+    `5c70881` daily update also created the new `sources/openwiki-version-drift.md`
+    auto-generated page).
 - **Auth:** local paths only — no remote, no credentials.
-- **Latest fetch:** `2026-08-15T18:07:49Z` (raw manifest
-  `~/.openwiki/connectors/git-repo/raw/2026-08-15T18-07-49-711Z/manifest.json`).
+- **Latest fetch:** `2026-08-17T18:09:32Z` (raw manifest
+  `~/.openwiki/connectors/git-repo/raw/2026-08-17T18-09-32-895Z/manifest.json`).
 - **Source config:** `~/.openwiki/connectors/git-repo/config.json`
 - **State:** `~/.openwiki/connectors/git-repo/state.json` records
-  `latestIds` per repo; the 2026-08-15 fetch observed vault HEAD
-  unchanged at `297f106d` (no new vault commits in the 24-hour window —
-  the 2026-08-12 Liang 2026 cluster of 4 commits is still the most
-  recent vault activity, and the 2026-08-13 cluster of 3 frontmatter-hygiene
-  + MOC-discipline commits + the 2026-08-11 cluster of 4 PMID deep-read
-  commits are all already merged into `297f106d`) and bumped
-  `openwiki-wiki` from `1737454` (2026-08-13) to `2507925` (2026-08-15,
-  4 new commits — `021e929` + `6258717` + `173b58c` + `2507925`).
+  `latestIds` per repo; the 2026-08-17 fetch observed vault HEAD
+  bumped from `297f106d` (2026-08-15 fetch) to `a4fa5a32` (7 new
+  vault commits in the 48-hour window) and bumped `openwiki-wiki`
+  from `2507925` (2026-08-15 fetch) to `be49285` (4 new wiki commits
+  in the same 48-hour window, plus 1 new wiki-side file
+  `sources/openwiki-version-drift.md`).
 
-## obsidian-vault — working-tree status (2026-08-15)
+## obsidian-vault — working-tree status (2026-08-17)
 
 - **Branch:** `main`
-- **HEAD:** `297f106d2b137af3480261052ff080cbc48d5b48` (vault HEAD
-  **unchanged** across the 2026-08-13 and 2026-08-15 fetches — 0 new
-  commits in either 24-hour window; the 2026-08-12 Liang 2026 cluster of
-  4 commits remains the most recent vault activity).
-- **Ahead of origin/main:** 13 commits new since 2026-08-03 fetch (same
-  count as the 2026-08-13 fetch — the 2026-08-12 Liang 2026 cluster of 4
-  commits is still the most recent vault activity).
-- **Dirty:** yes — the untracked file set is **unchanged** from the
-  2026-08-13 fetch (no new untracked files appeared in the 2026-08-15
-  24-hour window). The set is: 8 × `02-Clients/Agents/区域-2026-0807.md`
-  distributor-rebuild files (per the 2026-08-07 Hermes hook 4 sweep) +
-  the existing 15 working-folder files (Parfitt 2024 DJ1 LOF midbrain +
-  Liu2026 / Miao2025 v2 / Miao2025 vascularized / Microbioreactor 2026 /
-  `__pycache__/literature_deepread_v6.cpython-312.pyc` / `dify精读进度-20260805.md`
-  / `literature_deepread_v6.py` / `obsidian-vault/04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md`
+- **HEAD:** `a4fa5a323d6dcabeb9eccad49e636ee6ba5f87a6` (vault HEAD
+  **bumped** from `297f106d` across the 2026-08-17 fetch — **7 new
+  commits** in the 2026-08-15T18:07Z → 2026-08-17T18:09Z 48-hour
+  window: the 2026-08-16 **Quintard 2024 Nat Commun 4-commit LDR cycle**
+  + the 2026-08-16 **Guo 2026 Front Cell Dev Biol 3-commit LDR cycle**.
+  Two new paper LDR cycles in the same 48-hour window is the first time
+  this pattern has occurred since the 2026-07-28 / 2026-07-29 Parate /
+  Lee / Hodge cluster).
+- **Ahead of origin/main:** 20 commits new since 2026-08-03 fetch (was
+  13 at the 2026-08-15 fetch; the +7 delta is the Quintard 2024 +
+  Guo 2026 clusters).
+- **Dirty:** yes — the untracked file set **+2 new entries** in the
+  2026-08-17 48-hour window: `celvivo_commercial/1331651_20260630_131201.pdf`
+  (the 6-30 quote PDF, moved into a new folder) + `templates/类器官IRB申请清单.md`
+  (the IRB application checklist derived from Guo 2026; 180 lines; 7
+  mandatory points + 5 customer Q&A + China vs International flow + 10
+  attachments; Robin's first customer-facing template derived from a
+  single deep-read). The carry-forward untracked set is unchanged: 8
+  × `02-Clients/Agents/区域-2026-0807.md` distributor-rebuild files
+  (per the 2026-08-07 Hermes hook 4 sweep) + the existing 14 working-
+  folder files (Parfitt 2024 DJ1 LOF midbrain + Liu2026 / Miao2025 v2 /
+  Miao2025 vascularized / Microbioreactor 2026 / `__pycache__/literature_deepread_v6.cpython-312.pyc`
+  / `dify精读进度-20260805.md` / `literature_deepread_v6.py` /
+  `obsidian-vault/04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md`
   / `obsidian-vault/rustdesk-selfhosted-2026-08-05.md` /
   `retinal_organoid_deep_read_2026-08-07.md` / `文悦精读流水线.yml` + v2/v3/v4/v5-clean
   variants). The **`Review/zhou2023_computer_vision_microfluidics.md`
   first entry in the new `Review/` subfolder** is still **untracked**
   (Robin has not yet committed it) — the structural signal carried
-  forward from the 2026-08-13 fetch.
+  forward from the 2026-08-13 fetch and is **now joined** by 2 new
+  untracked working-tree directories (`celvivo_commercial/` + `templates/`).
 - **Working-tree status (raw manifest, abbreviated):**
 
   | Status | Path |
@@ -77,7 +96,9 @@ help locate things in the vault, not summarize their content.
   | `M` (committed 2026-08-12, `8699a154`) | same Liang 2026 file — page 946 9 项 SOP 重写版 (105+/122- lines) |
   | `M` (committed 2026-08-12, `aacba7aa`) | same Liang 2026 file — frontmatter title 改中文 + 与正文 H1 一致 (1-line touch) |
   | `M` (committed 2026-08-12, `297f106d`) | same Liang 2026 file — 修齐 page 934 标杆 (H1 去括号/元数据用bold/📄PDF文件名, 5+/4- lines) |
-  | `M` (committed 2026-08-10) | `04-Literature/Deep-Reads/Organoid/2026-07-29_Organoids_disease_modeling_treatment_2026_review.md` (Phase A batch frontmatter — `volume` / `pages` / `authors` array; also touched by `6b717aef` for related back-link) |
+  | `A` (committed 2026-08-16, `a4fa5a32`) | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` — **NEW external evidence** (Guo Z, Zhang N 2026 Front Cell Dev Biol DOI 10.3389/fcell.2026.1721946 — IRB / ethics systematic review; Wiki ID 1724, NocoDB Id 3298, 170 lines + 3 张真图; "与我们的产品" table lists CelVivo ClinoStar ⭐⭐⭐⭐ [临床转化类器官的伦理合规——7 大要点直接适用 IRB 申请] + Mimetas OrganoPlate ⭐⭐⭐⭐ [类器官 + 免疫细胞共培养伦理审查依据] + Emulate Organ-Chip ⭐⭐⭐; 3 commits `2e6f5989` → `00f824f2` → `a4fa5a32` = adds → -v2 修图床 → -v3 补 Fig 1) |
+| `A` (committed 2026-08-16, `0fc8db24`) | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` — **NEW external evidence** (Quintard C et al. 2024 Nat Commun DOI 10.1038/s41467-024-45710-4 — microfluidic platform for vascularized organoid chips; Wiki IDs 1719/1720/1722, NocoDB Id 3297; 4 commits `0fc8db24` → `290e9635` → `24c713de` → `4073abf4` = adds 189 lines → -v2 修图床/双 H1/落款 → -v3 Wiki.js 自带图床 6 张图 → -v4 转发语标题/落款加粗/删 3Brain; "与我们的产品" table lists Mimetas OrganoPlate ⭐⭐⭐⭐ [直接对标: Phaseguide 微流控技术用于血管化/肾/肠 organ-on-chip] + CelVivo ClinoStar ⭐⭐⭐ [类器官前段成熟期培养: BVO 在 hiPSC 分化到 day 15 需要悬浮旋转培养, ClinoStar 是该步骤的金标准; day 15 后才转入芯片, ClinoStar 是完整工作流的前置] + Emulate Organ-Chip ⭐⭐⭐) |
+| `M` (committed 2026-08-10) | `04-Literature/Deep-Reads/Organoid/2026-07-29_Organoids_disease_modeling_treatment_2026_review.md` (Phase A batch frontmatter — `volume` / `pages` / `authors` array; also touched by `6b717aef` for related back-link) |
   | `M` (committed 2026-08-10) | `CelVivo_精读报告_04_bioRxiv_PAH_Metabolomics.md` (Phase A batch frontmatter — `volume` / `pages` / `authors` array; also touched by `6b717aef`) |
   | `M` (committed 2026-08-10) | `obsidian-vault/04-Literature/Deep-Reads/3Brain/shin-2024-thalamocortical-organoids-22q11ds.md` (Phase A batch frontmatter; also touched by `6b717aef`) |
   | `M` (committed 2026-08-10) | `obsidian-vault/04-Literature/Deep-Reads/Cells/fernandez-vallone-2026-thsdc-brain-organoids.md` (Phase A batch frontmatter; also touched by `6b717aef`) |
@@ -86,6 +107,8 @@ help locate things in the vault, not summarize their content.
   | `M` (committed 2026-08-10) | `04-Literature/Deep-Reads/wang2024-org-on-chip.md` (方案 2 样品 — 6 frontmatter fields + 7 alt descriptions; also touched by `6b717aef`) |
   | `A` (committed 2026-08-10) | `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (方案 1 — **first MOC file**; 95 lines; 沙牛《AI 时代的 Obsidian 公开课》课时 1 pattern; `related:` already lists `[[MOC-3Brain-HD-MEA]]` as a forward link) |
   | `??` (untracked) | `02-Clients/Agents/全国经销商地图-2026-0807.md` + 7 区域 `*2026-0807.md` files (8-07 distributor baseline refresh — see below) |
+  | `??` (untracked, **NEW 2026-08-17**) | `celvivo_commercial/1331651_20260630_131201.pdf` — **NEW** untracked directory; the 6-30 quote PDF Robin migrated into a new `celvivo_commercial/` folder; companion to the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree |
+  | `??` (untracked, **NEW 2026-08-17**) | `templates/类器官IRB申请清单.md` — **NEW** untracked directory; the IRB application checklist derived from the Guo 2026 ethics-review deep-read (180 lines; 7 mandatory points [样本来源/知情同意/数据隐私/共培养主体性/3R 动物福利/跨境监管/长期保存与终止使用] + 5 customer Q&A + China vs International flow table + 10 attachments + 7 citations); Robin's **first customer-facing template** derived from a single deep-read — materializes the "Robin 业务定位: 类器官厂家给三甲医院 IRB 申请的标准模板 + Robin 客户培训材料核心" framing from the Guo 2026 deep-read |
   | `??` (untracked) | `04-Literature/Deep-Reads/Brain/2026-08-06_Parfitt_GM_et_al_NatCommun_2024_DJ1_LOF_midbrain_organoid_PD.md` |
   | `??` (untracked) | `Liu2026_NBME_shape_conformal_organoid.md` |
   | `??` (untracked) | `Miao2025_Cell_v2.md` |
@@ -111,6 +134,13 @@ help locate things in the vault, not summarize their content.
 
 | Date | Hash | Note |
 | --- | --- | --- |
+| 2026-08-16 | `a4fa5a32` | **literature: review 类 Guo 2026 -v3 补 Fig 1** — in-place update ID 1724, 3 张图全 |
+| 2026-08-16 | `00f824f2` | **literature: review 类 Guo 2026 -v2 修图床** — in-place update ID 1724, 加 2 张 Wiki.js 自带图 |
+| 2026-08-16 | `2e6f5989` | **literature: 精读 Guo 2026 Front Cell Dev Biol - 类器官伦理审查** (review 类, Wiki ID 1724, NocoDB Id 3298) — **NEW external evidence** (类器官研究 IRB / 伦理审查 7 大强制要点系统综述, 嘉兴市第一医院 + 嘉兴大学医学院视角) |
+| 2026-08-16 | `4073abf4` | **literature: 精读 Quintard 2024 -v4** — 转发语标题/落款加粗/删3Brain |
+| 2026-08-16 | `24c713de` | **literature: 精读 Quintard 2024 -v3 Wiki.js 自带图床** (ID 1722, 6 张图永久) |
+| 2026-08-16 | `290e9635` | **literature: 精读 Quintard 2024 -v2 修图床/双 H1/落款** (Wiki ID 1720) |
+| 2026-08-16 | `0fc8db24` | **literature: 精读 Quintard 2024 Nat Commun - 微流控血管化类器官芯片** (Wiki ID 1719, NocoDB Id 3297) — **NEW external evidence** (10 通道并行微流控 + hiPSC-BVO 30 天功能性灌注培养 + 跨类器官验证) |
 | 2026-08-12 | `297f106d` | **literature: 修齐 page 934 标杆** — H1 去括号 / 元数据用 bold / 📄PDF 文件名 (Liang 2026 v3) |
 | 2026-08-12 | `aacba7aa` | **literature: frontmatter title 改中文 + 与正文 H1 一致** (Liang 2026 v2) |
 | 2026-08-12 | `8699a154` | **literature: Liang 2026 Sci Rep liver organoid fibrosis - page 946 9 项 SOP 重写版** (Liang 2026 v2; 105+/122- lines; core-question / research-model / 6-finding 3-stage tables / 6 SeaFile Fig / "与我们的产品" 4-star / 4-paper refs / 转发语 / 完整落款) |
@@ -140,6 +170,60 @@ help locate things in the vault, not summarize their content.
 | 2026-07-28 | `2718e46d` | feat(literature): Parate 2020 SCRT — PEMF 增强 MSC 旁分泌功能促软骨再生 |
 | 2026-07-28 | `032de92f` | feat: 精读 Lee 2025 Front Vet Sci 犬脂肪源 MSC 3D 球体 |
 
+The **2026-08-16 cluster** is a **two-paper LDR cycle on the same day**
+covering both an **organ-on-chip microfluidic platform paper** and an
+**organoid ethical-review systematic-review paper**:
+
+- **Quintard C et al. (2024) Nat Commun DOI 10.1038/s41467-024-45710-4**
+  — a microfluidic platform for vascularized organoids-on-chip. The
+  paper establishes: (i) 10-channel parallel microfluidic chip (COC
+  热压成型, U 型捕获位 300-800 µm 可调); (ii) fibrin + Matrigel hydrogel
+  with Landau-Levich-Bretherton 效应 → 100% 捕获效率 in 10 sec per
+  channel; (iii) hiPSC-derived blood vessel organoids (BVO, day 15)
+  + GFP-HUVEC + 纤维细胞共培养 → 30 天功能性灌注培养; (iv) 壁剪切速率
+  27-2000 s⁻¹, mean 134-531 s⁻¹ (与人体毛细血管生理范围 50-1900 s⁻¹
+  完美匹配); (v) 层级化血管: 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管.
+  The 4 commits are the same single file
+  `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md`
+  walked through Robin's standard LDR cycle: (a) **`0fc8db24`** adds
+  the file (189 lines, single-pass entry); (b) **`290e9635`** rewrites
+  to -v2 修图床/双 H1/落款; (c) **`24c713de`** adds -v3 Wiki.js 自带
+  图床 6 张图 (永久); (d) **`4073abf4`** is the -v4 转发语标题/落款
+  加粗 + 删 3Brain 工具名硬门槛合规修正. The "与我们的产品" table on
+  the paper lists **Mimetas OrganoPlate ⭐⭐⭐⭐ (直接对标: Phaseguide
+  微流控技术)** + **CelVivo ClinoStar ⭐⭐⭐ (类器官前段成熟期培养:
+  BVO 在 hiPSC 分化到 day 15 需要悬浮旋转培养, ClinoStar 是该步骤
+  的金标准; day 15 后才转入芯片, ClinoStar 是完整工作流的前置)** +
+  **Emulate Organ-Chip ⭐⭐⭐**.
+- **Guo Z, Zhang N (2026) Front Cell Dev Biol DOI 10.3389/fcell.2026.1721946**
+  — an IRB / ethical-review systematic-review paper for organoid
+  biomedical research. The paper establishes: (i) **7 大强制要点**
+  (样本来源合法性 / 捐赠者知情同意 [unlimited expansion / long-term
+  cryopreservation / inter-lab sharing / cross-border / future
+  unspecified research / commercial use / withdrawal mechanism] /
+  数据隐私与去标识化 / 共培养产物主体性评估 [Guo 2026 首次提出] /
+  动物福利 3R 原则 / 跨境监管合规 [中国 / 美国 / 欧盟 / 日本 / 韩国
+  对照表] / 长期保存与终止使用); (ii) **中国 IRB 实务视角 + 国际
+  ISSCR / GDPR / OHRP 双重参照** (作者团队 = 嘉兴市第一医院医学伦理
+  委员会 + 嘉兴大学医学院, 中国 IRB 实践者); (iii) **共培养产物
+  "新伦理实体" 框架** = 类器官 + 免疫细胞共培养 (CAR-T 培养) 不构成
+  "新生物体" 但构成 "新伦理实体", 需要独立审查. The 3 commits are
+  the same single file
+  `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md`
+  walked through Robin's standard LDR cycle: (a) **`2e6f5989`** adds
+  the file (170 lines, single-pass entry); (b) **`00f824f2`** -v2 修
+  图床 (加 2 张 Wiki.js 自带图); (c) **`a4fa5a32`** -v3 补 Fig 1
+  (3 张图全) — Fig 1 is the "类器官共培养模型" 概念图 (Robin 8-16
+  实战反思: 综述类概念图通常较小, 提取阈值要从 0KB 起步全收, 再按
+  caption 关联; 之前 >200KB 过滤漏了 Fig 1). The "与我们的产品"
+  table on the paper lists **CelVivo ClinoStar ⭐⭐⭐⭐ (临床转化类
+  器官的伦理合规——本文 7 大要点直接适用于 ClinoStar 客户 IRB 申请;
+  Robin 推广 ClinoStar 给三甲医院时, 可附带本框架作为增值)** +
+  **Mimetas OrganoPlate ⭐⭐⭐⭐ (类器官共培养芯片的伦理审查依据——
+  Mimetas 主打"类器官 + 免疫细胞共培养", 本文主题 B 的共培养伦理
+  框架直接适用)** + **Emulate Organ-Chip ⭐⭐⭐ (类器官 + 微流控
+  芯片的跨境监管参考)**.
+
 The **2026-08-12 cluster** is a **single-paper LDR cycle** on
 **Liang Y et al. (2026) Sci Rep DOI 10.1038/s41598-026-42990-2** — a
 mouse liver organoid platform paper from 澳门科技大学 + 香港大学 that
@@ -175,6 +259,21 @@ working tree this fetch:
 — the **first entry in a new `Review/` subfolder** (see the
 Notable-entity section below).
 
+**7 new vault commits landed in the 2026-08-15T18:07Z →
+2026-08-17T18:09Z window** — the vault HEAD bumped from `297f106d`
+to `a4fa5a32`. The two 2026-08-16 LDR cycles (Quintard 2024
+microfluidic organ-on-chip + Guo 2026 organoid ethics systematic
+review) are the **first time since the 2026-07-28 / 2026-07-29
+Parate / Lee / Hodge cluster** that two new paper deep-reads landed
+on `main` in the same 48-hour window. The 2026-08-16 cluster
+replaces the 2026-08-12 Liang 2026 cluster as the most recent
+committed vault activity. Two new untracked directories appeared in
+the working tree this fetch: `celvivo_commercial/1331651_20260630_131201.pdf`
+(the 6-30 quote PDF migrated into a new folder) + `templates/类器官IRB申请清单.md`
+(the IRB application checklist derived from Guo 2026 — Robin's first
+customer-facing sales ammunition template produced from a single
+deep-read; see the Notable-entity section below for synthesis).
+
 The **2026-08-10 cluster** is a **frontmatter-hygiene + MOC-discipline
 sprint** rather than new external evidence: (a) **Phase A batch**
 (`d97b39ed`) standardized 6 deep-read notes with the structured 6-field
@@ -198,19 +297,18 @@ indexed on [`/sources/literature.md`](/sources/literature.md). The
 `1614ccf9`) are the 8-step SOP rewrite cycle (v3 → v11) Robin re-ran
 on the same paper.
 
-## openwiki-wiki — working-tree status (2026-08-15)
+## openwiki-wiki — working-tree status (2026-08-17)
 
 - **Branch:** `main`
-- **HEAD:** `2507925e27b83b4f9d2e6f3b9c939d081a90f9f2` (the
+- **HEAD:** `be4928553364a654b888807a44438b738072c2ce` (the
   `chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts
-  (sources-sync 2026-08-15)` commit — see Notable-entity §
-  "2026-08-15 sources-sync bug" for the count-data wipe this commit
-  carried into the source pages).
-- **Working-tree state:** 10 modified files (uncommitted — pending next
-  CLI orchestration). The dirty file set is the **accumulated
-  synthesis-layer edits from the prior 3 runs in this same 24-hour
-  window** (HN-1 2026-08-13 + HN-1 2026-08-15 + web-search-1 2026-08-15
-  + this git-repo-1 2026-08-15 run). The 10 dirty files are:
+  (sources-sync 2026-08-17)` commit — same auto-source-sync job that
+  carried the 2026-08-15 count-data wipe; see Notable-entity §
+  "2026-08-15 sources-sync bug" for the operational note).
+- **Working-tree state:** 9 modified files (uncommitted — pending next
+  CLI orchestration), **down from 10 at the 2026-08-15 fetch**
+  (the `sources/index.md` from the 2026-08-15 dirty set was committed
+  in the 2026-08-16 daily update `151d22b`). The 9 dirty files are:
   - `.last-update.json` — CLI metadata, will be updated when this run's
     `status: complete` lands.
   - `quickstart.md` — contains the accumulated "Latest update"
@@ -222,36 +320,53 @@ on the same paper.
     + added frontmatter placeholders to nocodb.md / ragflow.md /
     seafile.md / wikijs.md during the 2026-08-15 daily update.
   - `sources/hackernews.md` — accumulated "Latest update —
-    2026-08-15 18:00 UTC" section from the HN-1 2026-08-15 run (Auto-research
-    with codex 232x Faster Kernel flag-for-traceability + Working with AI
-    as Leadership + Yadda 3.0.0 BDD adjacent-off-scope callout section +
-    4th consecutive fully-zero Algolia lane streak note) — landed in
-    uncommitted state during the HN-1 2026-08-15 run.
-  - `sources/index.md` — accumulated description-only edits for
-    nocodb.md / ragflow.md / seafile.md / wikijs.md (frontmatter was
-    re-applied by the 2026-08-15 daily update, description lines
-    removed since they no longer match the placeholder scheme).
-  - `sources/nocodb.md` — frontmatter re-added during the 2026-08-15
-    daily update; **count data wiped** by `2507925` sources-sync
-    (NocoDB went from 6614 → 0 records).
-  - `sources/ragflow.md` — frontmatter re-added during the 2026-08-15
-    daily update; **count data wiped** by `2507925` sources-sync
-    (landing went from 200 → 000).
-  - `sources/seafile.md` — frontmatter re-added during the 2026-08-15
-    daily update; **count data wiped** by `2507925` sources-sync
-    (libraries table emptied).
+    2026-08-15 18:00 UTC" + "Latest update — 2026-08-16 18:00 UTC" +
+    "Latest update — 2026-08-17 18:00 UTC" sections from the prior
+    HN-1 2026-08-15 + HN-1 2026-08-16 + HN-1 2026-08-17 runs
+    (Auto-research with codex 232x Faster Kernel + Anthropic multi-agent
+    + Stripe/OpenRouter + Copilot Autofix + Qwen 3.8 27B + Agent Mesh
+    flag-for-traceability callouts + the 4th / 5th / 6th consecutive
+    empty / noise-only Algolia lane streak notes) — landed in
+    uncommitted state during the HN-1 runs.
+  - `sources/nocodb.md` — `openwiki_generated: true` placeholder
+    frontmatter auto-applied during the 2026-08-15 daily update +
+    carried forward in 2026-08-16 + 2026-08-17 daily updates; **count
+    data wiped** by `2507925` 2026-08-15 sources-sync (NocoDB went
+    from 6614 → 0 records).
+  - `sources/ragflow.md` — same `openwiki_generated: true` placeholder
+    auto-applied during the 2026-08-15 daily update; **count data
+    wiped** by `2507925` 2026-08-15 sources-sync (landing went from
+    200 → 000).
+  - `sources/seafile.md` — same `openwiki_generated: true` placeholder
+    auto-applied during the 2026-08-15 daily update; **count data
+    wiped** by `2507925` 2026-08-15 sources-sync (libraries table
+    emptied — SeaFile was already empty in `1737454` already — a
+    separate, older cron issue not introduced by `2507925`).
   - `sources/web-search.md` — accumulated "2026-08-15 attempted
-    update — skipped" section from the web-search-1 2026-08-15 run
-    (4th consecutive skip).
-  - `sources/wikijs.md` — frontmatter re-added during the 2026-08-15
-    daily update; **count data wiped** by `2507925` sources-sync
-    (Wiki.js went from 83 → 0 unique pages; ID range 22..1704 → 0..0).
+    update — skipped" + "2026-08-17 attempted update — skipped"
+    sections from the web-search-1 2026-08-15 + 2026-08-17 runs
+    (5th + 6th consecutive skips on the same code path).
+  - `sources/wikijs.md` — same `openwiki_generated: true` placeholder
+    auto-applied during the 2026-08-15 daily update; **count data
+    wiped** by `2507925` 2026-08-15 sources-sync (Wiki.js went from
+    83 → 0 unique pages; ID range 22..1704 → 0..0).
+- **Auth:** local path only — no remote, no credentials.
+- **New file in this window:** `sources/openwiki-version-drift.md`
+  was created in the 2026-08-17 daily update commit `5c70881` (auto-
+  generated page that tracks OpenWiki installed-vs-npm-latest version
+  drift; reports v0.3.1 local → v0.3.3 npm latest as of
+  2026-08-15T20:00:03Z; the page sits on the wiki to surface the
+  drift without an external daemon).
 - **Auth:** local path only — no remote, no credentials.
 
 ### Recent commits (latest first)
 
 | Date | Hash | Note |
 | --- | --- | --- |
+| 2026-08-17 | `be49285` | chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-17) |
+| 2026-08-17 | `5c70881` | chore: daily update 2026-08-17 (added `sources/openwiki-version-drift.md` auto-generated page + refreshed HN-1 / web-search-1 / git-repo-1 sections) |
+| 2026-08-16 | `997b648` | chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-16) |
+| 2026-08-16 | `151d22b` | chore: daily update 2026-08-16 (committed `sources/index.md` from the 2026-08-15 dirty set; refreshed HN-1 / web-search-1 / git-repo-1 / themes/05-robin-research sections) |
 | 2026-08-15 | `2507925` | chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-15) — **count-data wipe** (NocoDB 6614 → 0, Wiki.js 83 → 0, RAGFlow landing 200 → 000); see Notable-entity § "2026-08-15 sources-sync bug" |
 | 2026-08-15 | `173b58c` | chore: daily update 2026-08-15 (added OKF frontmatter to nocodb.md / ragflow.md / seafile.md / wikijs.md) |
 | 2026-08-14 | `6258717` | chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-14) |
@@ -316,14 +431,14 @@ from 2026-08-11 / 2026-08-12 (`7556e31` / `431ee6a` daily +
 next wiki commit should add a fuller Liang 2026 row when the synthesis
 pipeline catches up.
 
-### Summary of last 24 hours
+### Summary of last 48 hours
 
 | Window (UTC) | Vault | Wiki |
 | --- | --- | --- |
-| 2026-08-13T18:08:25Z → 2026-08-15T18:07:49Z | HEAD `297f106d` → `297f106d` (**0 new commits**; the 2026-08-12 Liang 2026 4-commit LDR cycle remains the most recent vault activity across both 2026-08-13 and 2026-08-15 fetches) | HEAD `1737454` → `2507925` (**4 new commits**: `021e929` daily update 2026-08-14 + `6258717` sources-sync 2026-08-14 + `173b58c` daily update 2026-08-15 + `2507925` sources-sync 2026-08-15) |
-| **Net new external evidence** | **none** — vault HEAD unchanged, untracked file set unchanged (the `Review/zhou2023_computer_vision_microfluidics.md` first-entry-in-Review/-subfolder is still untracked, carrying forward from the 2026-08-13 fetch) | **none** — synthesis layer only (HN-1 2026-08-13 MCP Memory using OKF refresh + HN-1 2026-08-15 Auto-research with codex flag-for-traceability + web-search-1 2026-08-15 4th-skip streak note all committed earlier; this run's edits are pending the next CLI commit) |
-| Untracked → committed migrations | none | none — the 10 dirty files (`.last-update.json` + `quickstart.md` + `sources/{README,hackernews,index,nocodb,ragflow,seafile,web-search,wikijs}.md`) are uncommitted synthesis edits accumulated across the prior HN-1 2026-08-13 + HN-1 2026-08-15 + web-search-1 2026-08-15 + git-repo-1 2026-08-15 runs, awaiting the next CLI commit cycle |
-| **Operational issue surfaced this run** | n/a | **`2507925` 2026-08-15 sources-sync bug**: this sync committed empty NocoDB / SeaFile / Wiki.js / RAGFlow count values (NocoDB 6614 → 0, Wiki.js 83 → 0, RAGFlow landing 200 → 000). The on-disk `~/.openwiki/connectors/web-search/config.json` is unaffected — this is a wiki-side CRON issue with the auto-source-sync job, not a connector config issue. Recorded for traceability on `/sources/git-repo.md` Notable-entity § "2026-08-15 sources-sync bug" and on each affected `/sources/{nocodb,ragflow,seafile,wikijs}.md` page (each of those pages now shows `上次同步: 2026-08-14T18:30:42Z` — the prior successful sync — plus zero / null / 000 count values from the failed 2026-08-15 sync). The data is recoverable from `git show 8ddc6d9:sources/nocodb.md` etc. for any future recovery commit |
+| 2026-08-15T18:07:49Z → 2026-08-17T18:09:32Z | HEAD `297f106d` → `a4fa5a32` (**7 new commits**: `0fc8db24` + `290e9635` + `24c713de` + `4073abf4` Quintard 2024 Nat Commun microfluidic vascularized organoid chip 4-commit LDR cycle + `2e6f5989` + `00f824f2` + `a4fa5a32` Guo 2026 Front Cell Dev Biol organoid ethics systematic review 3-commit LDR cycle — **first time since the 2026-07-28 / 2026-07-29 Parate / Lee / Hodge cluster that two new paper deep-reads landed on `main` in the same 48-hour window**) | HEAD `2507925` → `be49285` (**4 new commits**: `151d22b` daily update 2026-08-16 + `997b648` sources-sync 2026-08-16 + `5c70881` daily update 2026-08-17 + `be49285` sources-sync 2026-08-17) |
+| **Net new external evidence** | **2 new paper deep-reads**: Quintard 2024 Nat Commun microfluidic vascularized organoid chip + Guo 2026 Front Cell Dev Biol organoid ethics systematic review. **2 new untracked directories**: `celvivo_commercial/1331651_20260630_131201.pdf` (the 6-30 quote PDF migrated into a new folder) + `templates/类器官IRB申请清单.md` (the IRB application checklist derived from Guo 2026 — Robin's first customer-facing sales ammunition template produced from a single deep-read). The `Review/zhou2023_computer_vision_microfluidics.md` first-entry-in-Review/-subfolder is still untracked, carrying forward from the 2026-08-13 fetch | **1 new wiki file**: `sources/openwiki-version-drift.md` (auto-generated OpenWiki version-drift monitor; v0.3.1 local → v0.3.3 npm latest as of 2026-08-15T20:00:03Z). Synthesis-layer edits accumulated across the prior HN-1 2026-08-13 + HN-1 2026-08-15 + HN-1 2026-08-16 + HN-1 2026-08-17 + web-search-1 2026-08-15 + web-search-1 2026-08-17 + git-repo-1 2026-08-13 + git-repo-1 2026-08-15 runs are pending the next CLI commit cycle |
+| Untracked → committed migrations | **Quintard 2024 file (4 commits)** + **Guo 2026 file (3 commits)** all moved from absent → committed on `main`; **the 2 new untracked directories** are net-new in this window | **none** of the 9 dirty files were committed in this window (the `sources/index.md` from the 2026-08-15 dirty set was committed by the 2026-08-16 daily update `151d22b`; the remaining 9 dirty files are uncommitted synthesis edits accumulated across the prior HN-1 + web-search-1 + git-repo-1 runs); the 9 dirty files (`.last-update.json` + `quickstart.md` + `sources/{README,hackernews,nocodb,ragflow,seafile,web-search,wikijs}.md`) are awaiting the next CLI commit cycle |
+| **Operational issue carried over from prior runs** | n/a | **`2507925` 2026-08-15 sources-sync bug** + the 2026-08-16 `997b648` + 2026-08-17 `be49285` sources-syncs (which re-applied the same operational pattern as `2507925` — NocoDB / Wiki.js / RAGFlow count values stayed zero across all 3 sources-syncs). The on-disk `~/.openwiki/connectors/web-search/config.json` is unaffected — this is a wiki-side CRON issue with the auto-source-sync job, not a connector config issue. Recorded for traceability on `/sources/git-repo.md` Notable-entity § "2026-08-15 sources-sync bug" and on each affected `/sources/{nocodb,ragflow,seafile,wikijs}.md` page. The data is recoverable from `git show 8ddc6d9:sources/nocodb.md` etc. for any future recovery commit |
 
 ## Vault navigation index
 
@@ -357,7 +472,7 @@ Markdown file counts per deep-read subfolder:
 
 | Subfolder | .md count |
 | --- | --- |
-| `Organoid/` | 659 |
+| `Organoid/` | 661 (+2 from 2026-08-16 — Quintard 2024 Nat Commun microfluidic vascularized organoid chip + Guo 2026 Front Cell Dev Biol organoid ethics systematic review) |
 | `Celvivo/` | 142 |
 | `3Brain/` | 136 |
 | `Cellink/` | 129 |
@@ -376,13 +491,13 @@ Markdown file counts per deep-read subfolder:
 | `Microbioreactor/` | 1 (new as of 2026-08-07 — Rosero 2026 Front Bioeng Biotechnol) |
 | `Cells/` | 1 (new as of 2026-08-08 — Fernandez Vallone 2026 Cells THSDC) |
 | `Review/` | 1 (new as of 2026-08-13 — Zhou 2023 computer vision + microfluidics, **untracked**) |
+| `templates/` | 1 (new as of 2026-08-17 — `类器官IRB申请清单.md`, derived from the Guo 2026 ethics deep-read; Robin's first customer-facing template produced from a single deep-read, **untracked**) |
+| `celvivo_commercial/` | 1 (new as of 2026-08-17 — `1331651_20260630_131201.pdf`, the 6-30 quote PDF migrated into a new folder, **untracked**) |
 
-Total ≈ 1,205 deep-read notes (+1 from the 2026-08-13 cluster:
+Total ≈ 1,207 deep-read notes on `main` (+2 from the 2026-08-16 Quintard 2024 + Guo 2026 clusters).
 Review/ zhou2023 computer vision + microfluidics, **untracked** — only
-counts once committed). The 2026-08-07 / 2026-08-08 cluster (Microbioreactor
-+ Cells) remains the most recent committed deep-read additions. CelVivo,
-3Brain, Cellink, and the broad `Organoid/` bucket cover Robin's product
-KB per the wiki goal focus areas (类器官培养与设备, 3D 生物打印).
+counts once committed; +2 working-tree files in the new `templates/` +
+`celvivo_commercial/` directories, both untracked). The 2026-08-16 Quintard 2024 + Guo 2026 cluster is the most recent committed deep-read additions; the 2026-08-07 / 2026-08-08 cluster (Microbioreactor + Cells) remains the prior committed cluster. CelVivo, 3Brain, Cellink, and the broad `Organoid/` bucket cover Robin's product KB per the wiki goal focus areas (类器官培养与设备, 3D 生物打印). The new `templates/` folder signals Robin may be formalizing customer-facing deliverables (checklists / templates / sales scripts) as a separate vault subtree — the IRB application checklist is the first such artifact.
 
 ## Distributor map refresh (2026-08-07)
 
@@ -443,7 +558,11 @@ fields still 待补).
 
 ## Notable entities surfaced by the vault (structural hints only)
 
-- **Review/ subfolder — first entry (2026-08-13, still uncommitted at 2026-08-15)** — `obsidian-vault/04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md` is the **first file in a new `Review/` subfolder** under `04-Literature/Deep-Reads/`. The file is **untracked** at the 2026-08-15 fetch (Robin has not yet committed it — same state as the 2026-08-13 fetch, 0 progress in the 2026-08-13 → 2026-08-15 24-hour window), so the synthesis is provisional, but the path naming convention (`zhou2023_computer_vision_microfluidics.md`) matches Robin's standard deep-read naming pattern (`author-year-keyword-keyword.md`). Likely content: Zhou et al. (2023) computer-vision + microfluidics cross-review paper — a **review-type** paper (rather than an original-research paper) that Robin is collecting as part of his broader organoid + microfluidic cross-anchor reading list. **Structural significance**: the `Review/` subfolder is new — none of the existing 19 subfolders (`Organoid/`, `Celvivo/`, `3Brain/`, `Cellink/`, `Organoid-List/`, `Product-Reports/`, `Brain/`, `Brain-Tumor/`, `Cancer/`, `Liver/`, `Other/`, `RegenMed/`, `3Brain MEA/`, `Cardiac/`, `Kidney/`, `Retinal/`, `Microbioreactor/`, `Cells/`) explicitly segregates review-type papers. A `Review/` subfolder signals Robin may be formalizing the review-paper stream separately from the original-research stream. **No synthesis routes** until the file is committed — the deep-read synthesis page + any vendor-mapping should land after Robin commits the file and the standard 8-step LDR pipeline publishes it to Wiki.js / NocoDB / SeaFile. Track on the next git-repo fetch whether (a) the file is committed, (b) the `Review/` subfolder accumulates additional entries, and (c) the standard page-946 9 项 SOP + page-934 修齐 alignment is applied. **Carry-forward status** (2026-08-13 → 2026-08-15): unchanged. The `Review/` subfolder is still single-entry, still untracked, no follow-up paper landed in this subfolder in the 48-hour window since the first observation. Watchlist trigger: if the file remains uncommitted at the next fetch (2026-08-17 or later), the structural signal weakens (single-entry subfolder could be a one-off rather than a recurring pattern).
+- **Quintard 2024 Nat Commun microfluidic vascularized organoid chip (2026-08-16, 7 commits in 48-hour window)** — `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` (189 lines; 4-commit LDR cycle `0fc8db24` adds → `290e9635` -v2 修图床/双 H1/落款 → `24c713de` -v3 Wiki.js 自带图床 6 张图 → `4073abf4` -v4 转发语标题/落款加粗/删 3Brain; Wiki IDs 1719/1720/1722, NocoDB Id 3297). The paper is **the first microfluidic / organ-on-chip platform paper** Robin has deep-read in the 2026-08 window; the platform combines (i) 10-channel parallel microfluidic chips with U-shaped capture sites (300-800 µm adjustable), (ii) fibrin + Matrigel hydrogel layer deposition using Landau-Levich-Bretherton effect, (iii) ~10 s capture efficiency ~100%, (iv) dynamic perfusion 7-30 days with HUVEC + fibroblast co-culture + hiPSC-derived BVO + islet spheroid + lung organoid cross-validation, (v) hierarchical vasculature (37 µm upstream artery-vein + 8 µm BVO capillaries, matching physiological ranges 50-1900 s⁻¹). **Net-new external evidence** in this run (git-repo-1 2026-08-17). The 4-star "与我们的产品" table lists **Mimetas OrganoPlate ⭐⭐⭐⭐** (direct Phaseguide-based vascularized / kidney / intestine organ-on-chip competitor) + **CelVivo ClinoStar ⭐⭐⭐** (upstream workflow step: BVO differentiation day 0-15 needs rotating-wall suspension culture; ClinoStar is the canonical hardware for this stage; the paper's day 15 → chip-on-board handoff is the canonical CelVivo → organ-on-chip workflow) + **Emulate Organ-Chip ⭐⭐⭐** (Colon-Intestine-Liver platform companion). Synthesis routes into `/themes/05-robin-research.md` (新增 by-vendor entry) and `/sources/literature.md` (last-30-days deep-read table). Vendor-anchor mapping: CelVivo-adjacent (workflow upstream) + Mimetas OrganoPlate / Emulate Organ-Chip (organ-on-chip product lane that Robin's portfolio does not currently cover but represents a potential cross-sell if Robin's customers ask "where do I run my CelVivo-matured organoids in a vascularized microenvironment?"). Customer-entry: 药企临床前 (vascularized drug screening) + 微流控 organ-on-chip 平台集成商 (Mimetas / Emulate channel partners) + academic PI (vascular development / diabetes). **Track on next fetch** whether Robin publishes a `/sources/literature-quintard-2024-nat-commun-vasorganoid-chip-deepread.md` synthesis page; the deep-read pipeline currently only carries `liang-2026-celvivo-clinostar-positioning` + `miao-2025-celvivo-clinostar-positioning` + `liu-2026-hd-mea-roadmap-implication` + `sharma-2026-retinal-organoid-mea-cross-sell` — no Quintard synthesis page yet.
+- **Guo 2026 Front Cell Dev Biol organoid ethics systematic review (2026-08-16, 7 commits in 48-hour window)** — `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` (170 lines + 3 真图; 3-commit LDR cycle `2e6f5989` adds → `00f824f2` -v2 修图床 (加 2 张 Wiki.js 自带图) → `a4fa5a32` -v3 补 Fig 1; Wiki ID 1724, NocoDB Id 3298). The paper is **the first organoid-research ethics / IRB systematic review** Robin has deep-read in any window — fills the methodological gap on the IRB-side that the prior clinical-translation evidence (CDE classification + Order No. 818) does not directly cover. The paper structures the IRB review framework as **7 mandatory points** (sample provenance + donor informed consent + data privacy & de-identification + co-culture agency + animal welfare 3R + cross-border regulation + long-term storage & termination); the cross-border table compares China (《人类遗传资源管理条例》+ 《涉及人的生命科学和医学研究伦理审查办法》2023), US (HIPAA + Common Rule + NIH GDS), EU (GDPR + Clinical Trials Regulation 536/2014), Japan, Korea. The 4-star "与我们的产品" table lists **CelVivo ClinoStar ⭐⭐⭐⭐** (clinical-translation IRB compliance — the 7 mandatory points directly apply to ClinoStar customer IRB submissions; **Robin 推广 ClinoStar 给三甲医院时, 可附带本框架作为增值**) + **Mimetas OrganoPlate ⭐⭐⭐⭐** (co-culture ethics — Mimetas 主营类器官 + 免疫细胞共培养, the co-culture agency framework from Guo 2026 point 4 directly applies) + **Emulate Organ-Chip ⭐⭐⭐** (organoid + microfluidic cross-border regulation reference). **Net-new external evidence** in this run (git-repo-1 2026-08-17). Robin translated the paper into a **customer-facing sales ammunition template** at `templates/类器官IRB申请清单.md` (180 lines; 7 mandatory points checklist + 5 customer Q&A + China vs International flow table + 10 attachments + 7 citations; v1.0 dated 2026-08-16, "Robin 8-16 实战沉淀") — see the templates/ entry in the next bullet. Customer-entry: 临床转化型医院 (class A tertiary hospitals running organoid IRB submissions) + 类器官厂家 Robin 培训客户 (the IRB checklist is the canonical "Robin 培训客户 IRB 申请" core material) + academic PI (cross-border collaboration IRB paperwork). **Track on next fetch** whether (a) the templates/ IRB checklist gets committed, (b) the Robin-author attribution in the template is recognized as a wiki-side customer-training artifact, (c) Robin produces a deep-read synthesis page at `/sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md`, and (d) the IRB checklist routes into the existing CelVivo industrial-customers program (which currently lives at `05-Documents/Products/Celvivo/Industrial-Customers/`) as a standard customer-training artifact.
+- **Review/ subfolder — first entry (2026-08-13, still uncommitted at 2026-08-17, 4-day carry-forward, watchlist signal weakening)** — `obsidian-vault/04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md` is the **first file in a new `Review/` subfolder** under `04-Literature/Deep-Reads/`. The file is **untracked** at the 2026-08-17 fetch (Robin has not yet committed it — same state as the 2026-08-13 + 2026-08-15 fetches, 0 progress in the 2026-08-13 → 2026-08-17 96-hour window). **Watchlist trigger met at this fetch**: per the 2026-08-15 watchlist-trigger rubric ("if the file remains uncommitted at the next fetch (2026-08-17 or later), the structural signal weakens"), the `Review/` subfolder at the 2026-08-17 fetch is **still single-entry, still untracked** — the structural signal **does weaken** at this fetch (4-day carry-forward with no commit, no follow-up paper landed in the subfolder). The `Review/` subfolder is more likely to be a one-off than a recurring pattern. The file should either be committed on a future fetch (which would re-strengthen the signal) or remain untracked indefinitely (which would confirm the one-off interpretation). No synthesis routes until the file is committed.
+- **`templates/` subfolder — first entry (2026-08-16, NEW this run)** — `templates/类器官IRB申请清单.md` (180 lines, mtime 2026-08-16, untracked) is the **first file in a new `templates/` directory** at the vault root. The file is Robin's **first customer-facing sales ammunition template produced from a single deep-read** (the Guo 2026 IRB ethics systematic review). Content: 7 mandatory IRB review points checklist (样本来源/知情同意/数据隐私/共培养主体性/3R 动物福利/跨境监管/长期保存与终止使用) + 5 customer Q&A ("类器官研究要不要 IRB 申请?" / "类器官共培养产品怎么申请 IRB?" / "类器官跨境研究怎么报?" / "3R 原则怎么写?" / "类器官 + 免疫细胞共培养 = CAR-T 体外培养, 算不算新生物体? 伦理上算什么?") + China vs International flow comparison table + 10-row 申请附件清单 + 7 references (Guo 2026 + ISSCR 2021 + OHRP 2016 + GDPR 2018 + China 2023 + China 2019 + Cambridge 2020). The template's `version: v1.0 (2026-08-16, Robin 8-16 实战沉淀)` and `Robin 业务定位: 类器官厂家给三甲医院 IRB 申请的标准模板 + Robin 客户培训材料核心` framing makes it explicit that this is the canonical "Robin 培训客户 IRB 申请" core material. **Structural significance**: the `templates/` directory is new — none of the existing top-level folders (`01-Active-Sales/` / `02-Clients/` / `02-Active-Deals/` / `02-Contacts/` / `03-Product/` / `03-Resources/` / `04-Literature/` / `05-Documents/` / `06-Sales/` / `99-Templates/` / `memory/`) provides a vendor-agnostic customer-training-artifact slot at the vault root. The Obsidian vault already has `99-Templates/` for reusable Obsidian templates (note templates, daily-report templates — per `99-Templates/` size hint 14 .md), but the new `templates/` directory is **for customer-facing sales ammunition**, not Obsidian note templates — a different artifact type. The naming convention overlaps with `99-Templates/` and may need disambiguation; Robin's intent (per the file header) is for this `templates/` to be the **canonical customer-training artifact directory**, distinct from `99-Templates/` Obsidian-note templates. **Customer-entry scenarios** called out in the template: (a) 类器官厂家研发负责人 = IRB 申请准备, (b) Robin 客户开发 = 培训客户 IRB 申请核心材料, (c) 医院 IRB 委员会 = 类器官研究 IRB 审查标准参考, (d) 学术合作方 = 跨境合作时多国法规差异对照. **Carry-forward status** (2026-08-17): untracked, future-commit candidate. **Track on next fetch** whether (a) Robin commits the file to `main`, (b) more templates land in the directory (extending the customer-training-artifact slot), (c) the `templates/` and `99-Templates/` naming overlap gets resolved (rename / docs / conventions). Synthesis routes into `/themes/05-robin-research.md` (sales ammunition pipeline section).
+- **`celvivo_commercial/` subfolder — first entry (2026-08-17, NEW this run)** — `celvivo_commercial/1331651_20260630_131201.pdf` (56 KB PDF, mtime 2026-08-17, untracked) is the **first file in a new `celvivo_commercial/` directory** at the vault root. The PDF is the existing 6-30 quote PDF that Robin migrated into a new folder. The file is **a quote PDF**, not a synthesis target — the on-disk evidence is the existing 6-30 quote document that already exists in `05-Documents/Products/Celvivo/Industrial-Customers/` (per the 2026-08-15 synthesis-policy section above, "commercial docs (8 files: Exhibit 1 Price Book / Exhibit 3 SuperUser certification / Huibai demo discount agreement / 惠百 PO 盖章版 / Celvivo Distribution Agreement 2026 Huibai Bio / 1331651_20260630_131201 (6-30 quote) / Packing Slip Ordre 726_1 / Packing Slip Ordre 726_2)"). **Structural significance**: the `celvivo_commercial/` directory is new — Robin has migrated the 6-30 quote out of wherever it was previously (presumably a working folder or `05-Documents/Products/Celvivo/` deep path) into a top-level dedicated directory. **The migration is unfinished** — only 1 file in the new directory; if Robin intends the directory to consolidate all 8 commercial docs from `05-Documents/Products/Celvivo/Industrial-Customers/`, the other 7 files (Exhibit 1 Price Book / Exhibit 3 SuperUser certification / Huibai demo discount agreement / 惠百 PO 盖章版 / Celvivo Distribution Agreement 2026 / Packing Slip Ordre 726_1 / Packing Slip Ordre 726_2) should eventually land here too. **No synthesis routes** until Robin commits the file or migrates more docs into the directory. Carry-forward status (2026-08-17): untracked, single-entry, future-commit candidate. Track on next fetch whether (a) the file gets committed, (b) more commercial docs migrate into the directory.
 - **2026-08-15 sources-sync bug — count-data wipe (operational)** — the `2507925e27b83b4f9d2e6f3b9c939d081a90f9f2` `chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-15)` commit at 2026-08-15 +0800 02:31 committed **empty count values** for NocoDB / Wiki.js / RAGFlow (SeaFile was already empty so the commit was a no-op there): (a) NocoDB: 6614 → **0** total records, with all 13 per-table counts (brain_organoid_literature / intestinal_organoid_literature / Celvivo_literature / cardiac_organoid_literature / cancer_organoid_literature / liver_organoid_literature / other_organoid_literature / kidney_organoid_literature / retinal_organoid_literature / Cellink_literature / organoid_literature_old / lung_organoid_literature / 3Brain_literature) cleared to empty cells; (b) SeaFile: libraries table unchanged (was empty in `1737454` already — a separate, older cron issue not introduced by `2507925`); (c) Wiki.js: 83 → **0** unique pages, ID range 22..1704 → **0..0**, Locale 分布 → empty, Top-level 路径分布 → empty; (d) RAGFlow: landing 200 → **000**, `/api/v1/health` 404 → **000**, `/api/v1/datasets` 401 → **000**. The header lines on each affected `/sources/{nocodb,ragflow,seafile,wikijs}.md` page still report `上次同步: 2026-08-14T18:30:42Z` (the prior successful sync timestamp), but the body count values are wiped. **Probable root cause**: the auto-source-sync CRON job ran but the underlying NocoDB / Wiki.js / RAGFlow API calls failed (likely the same operational issue already documented on `/sources/web-search.md` and `/sources/README.md` — runtime registry disagreement on `enabled: true` vs. disabled); the script committed the empty values instead of skipping the commit on failure. **Impact**: 3 source pages now show misleading zero/null values (NocoDB / Wiki.js / RAGFlow); Tavily / HN / git-repo synthesis is unaffected. **Recovery**: the wiped data is recoverable from the prior wiki commit (`git show 1737454:sources/nocodb.md` etc. will restore the pre-wipe state). This run restored the wiped data on all 3 affected pages (plus an operational note documenting the bug) so the wiki is internally consistent again. **Wiki-synthesis concern**: **none** — the synthesis layer (themes / commitments / open-questions / personal-logistics) is independent of the source-page counters. **Operational concern**: **yes** — the auto-source-sync job should (a) check connectivity before committing, (b) skip the commit on API failure rather than committing empty values, or (c) preserve the prior counter values when a fresh pull returns null/empty. Recorded for traceability here + on each affected `/sources/{nocodb,ragflow,seafile,wikijs}.md` page.
 - **Liang 2026 liver organoid fibrosis platform (2026-08-12)** — `04-Literature/Deep-Reads/Liver/2026-08-12_Liang_2026_SciRep_liver_organoid_fibrosis_platform.md` (170 lines; `[[MOC-类器官与3D培养]]` already names this paper via `related:` back-link). The paper is **the net-new external evidence** this run (git-repo-1 2026-08-12) brought into the vault; see synthesis at `/themes/01-organoid-equipment.md` § CelVivo evidence (added 2026-08-12) and `/commitments.md` `liang-2026-celvivo-clinostar-positioning`. Single-paper LDR cycle: 4 commits (`e542c977` → `8699a154` → `aacba7aa` → `297f106d`) walked Robin's standard 3-stage SOP on the same file (186 lines → 105+/122- page 946 rewrite → page 934 修齐 micro-revisions). The 4-star "与我们的产品" table on the paper lists **CelVivo ClinoStar ⭐⭐⭐⭐** (P1-P10 长程扩增对应旋转培养 30+ 天无剪切; HSC 静止态在模拟微重力下 7+ 天维持) + **CelVivo ClinoReactor ⭐⭐⭐⭐** (单组织 3 轨道分通道灌流; TGFβ 时间程序精确切换) — **parallel CelVivo ClinoStar rating 5 to Miao 2025 v2's ClinoStar rating 5** from the 2026-08-08 flywheel-sync, but for liver organoid (long-term maturation + fibrosis modeling) rather than lung organoid (vascularization). 7 SeaFile Fig (Fig1-7) + 4-paper 参考文献 (Huch 2013 / Huch 2015 / Clevers 2016). Customer-entry: 药企临床前 (抗纤维化药筛) + 临床肝活检中心 (1-2 mg → 3 周药敏) + 学术 PI (2D vs 3D 旋转 efficiency). **MOC linkage**: the paper's `related:` field already names `[[MOC-类器官与3D培养]]` (the first MOC, created 2026-08-10) — confirming the MOC pattern is in active use on real deep-reads.
 - **CelVivo industrial customers program** — a dedicated subfolder under
@@ -526,15 +645,118 @@ fields still 待补).
 
 ## Synthesis policy for this source
 
-- **This run (2026-08-15, git-repo-1 18:07Z):** **0 new vault commits**
-  in the 2026-08-13T18:08Z → 2026-08-15T18:07Z window — the vault HEAD
-  is unchanged at `297f106d` across **both** the 2026-08-13 and
-  2026-08-15 fetches (the 2026-08-12 Liang 2026 4-commit LDR cluster
-  remains the most recent vault activity). **No new untracked files**
-  in the 24-hour window — the untracked file set is unchanged from
-  the 2026-08-13 fetch (the `Review/zhou2023_computer_vision_microfluidics.md`
-  first-entry-in-Review/-subfolder is still untracked, carrying
-  forward). Wiki-side: **4 new wiki commits** landed (`021e929` daily
+- **This run (2026-08-17, git-repo-1 18:09Z):** **7 new vault commits**
+  landed in the 2026-08-15T18:07Z → 2026-08-17T18:09Z window — the vault
+  HEAD bumped from `297f106d` (the 2026-08-12 Liang 2026 cluster) to
+  `a4fa5a32` (the 2026-08-16 Quintard 2024 + Guo 2026 cluster). The
+  cluster breaks down as: (a) **Quintard 2024 Nat Commun 4-commit LDR
+  cycle** (`0fc8db24` adds 189 lines → `290e9635` -v2 修图床/双 H1/落款
+  → `24c713de` -v3 Wiki.js 自带图床 6 张图 → `4073abf4` -v4 转发语标题/
+  落款加粗/删 3Brain) on `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md`;
+  (b) **Guo 2026 Front Cell Dev Biol 3-commit LDR cycle** (`2e6f5989`
+  adds 170 lines → `00f824f2` -v2 修图床 (加 2 张 Wiki.js 自带图) →
+  `a4fa5a32` -v3 补 Fig 1) on
+  `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md`.
+  The 2026-08-16 cluster is **the first time since the 2026-07-28 /
+  2026-07-29 Parate / Lee / Hodge cluster** that two new paper deep-reads
+  landed on `main` in the same 48-hour window, and **the first time a
+  review-type IRB / ethics systematic review (Guo 2026) was deep-read**
+  in any vault window. **2 new untracked directories** appeared in
+  the working tree this fetch: (a) `celvivo_commercial/1331651_20260630_131201.pdf`
+  (the 6-30 quote PDF migrated into a new folder); (b) `templates/类器官IRB申请清单.md`
+  (the IRB application checklist Robin produced from the Guo 2026
+  review — Robin's **first customer-facing sales ammunition template**
+  derived from a single deep-read). The 23 untracked working-tree
+  files from the 2026-08-13 fetch are unchanged at this fetch (the
+  `Review/zhou2023_computer_vision_microfluidics.md` first-entry-in-Review/-subfolder
+  is still untracked, now a **4-day carry-forward** with watchlist
+  signal weakening per the Notable-entity entry). Wiki-side: **4 new
+  wiki commits** landed (`151d22b` daily update 2026-08-16 +
+  `997b648` sources-sync 2026-08-16 + `5c70881` daily update 2026-08-17
+  (created the new `sources/openwiki-version-drift.md` auto-generated
+  page) + `be49285` sources-sync 2026-08-17), advancing HEAD from
+  `2507925` (2026-08-15) to `be49285` (2026-08-17). 9 dirty wiki files
+  in the working tree (`.last-update.json` + `quickstart.md` +
+  `sources/README.md` + `sources/hackernews.md` + `sources/nocodb.md`
+  + `sources/ragflow.md` + `sources/seafile.md` + `sources/web-search.md`
+  + `sources/wikijs.md`) are **accumulated** synthesis-layer edits
+  from the prior HN-1 2026-08-15 + HN-1 2026-08-16 + HN-1 2026-08-17 +
+  web-search-1 2026-08-15 + web-search-1 2026-08-17 + git-repo-1
+  2026-08-15 runs that are pending the next CLI orchestration commit
+  (down from 10 dirty files at the 2026-08-15 fetch — `sources/index.md`
+  got committed in the `151d22b` 2026-08-16 daily update). One
+  **new wiki file** added in the window: `sources/openwiki-version-drift.md`
+  (auto-generated OpenWiki version drift monitor; reports `v0.3.1` local
+  → `v0.3.3` npm latest as of 2026-08-15T20:00:03Z with a manual
+  `npm install -g openwiki@latest` action and a WARNING that v0.3.1 →
+  v0.4+ may have breaking changes; the page is informational, not a
+  synthesis target). **No `/commitments.md` row, no
+  `/open-questions.md` row, no `/personal-logistics.md` item**
+  added this run beyond the canonical synthesis pipeline — the
+  Quintard 2024 deep-read has no existing synthesis page yet (the
+  deep-read pipeline currently only carries `liang-2026-celvivo-clinostar-positioning`
+  + `miao-2025-celvivo-clinostar-positioning` + `liu-2026-hd-mea-roadmap-implication`
+  + `sharma-2026-retinal-organoid-mea-cross-sell`); the Guo 2026 IRB
+  review is the first ethics-side deep-read and the IRB checklist
+  template is the first customer-facing sales ammunition template,
+  both of which warrant a commitment + a synthesis page on a future
+  fetch. Wiki edits this run: (a) `/sources/git-repo.md` (this page)
+  — refreshed frontmatter HEAD pointers (vault HEAD `297f106d` →
+  `a4fa5a32`, wiki HEAD `2507925` → `be49285`, tags + `2026-08-17`,
+  timestamp → `2026-08-17T18:09:32Z`), refreshed the Connector / State
+  section to the new `2026-08-17T18-09-32-895Z` raw manifest, refreshed
+  the obsidian-vault working-tree-status section to 2026-08-17 (7 new
+  vault commits, 2 new untracked dirs, the `Review/zhou2023_computer_vision_microfluidics.md`
+  carries forward as still-untracked), refreshed the
+  Recent-commits-for-vault table to put the 7 new 2026-08-16 commits
+  on top of the 2026-08-12 cluster, refreshed the openwiki-wiki
+  working-tree-status section to 2026-08-17 (4 new wiki commits + 9
+  uncommitted synthesis-layer edits — `sources/index.md` got committed
+  in `151d22b`), refreshed the Recent-commits-for-wiki table to put
+  the 4 new 2026-08-16/2026-08-17 commits on top of the 2026-08-15
+  cluster, refreshed the Summary-of-last-48-hours table to add the
+  2026-08-15T18:07Z → 2026-08-17T18:09Z window data (7 vault commits /
+  4 wiki commits / 9 uncommitted wiki files / 1 new wiki file +
+  2 new untracked dirs + 4-day carry-forward on `Review/` subfolder),
+  refreshed the Notable-entity section to add (a) "Quintard 2024
+  microfluidic vascularized organoid chip" entry (with 4-star
+  Mimetas/CelVivo/Emulate mapping), (b) "Guo 2026 organoid ethics
+  systematic review" entry (with 4-star Mimetas/CelVivo/Emulate
+  mapping + IRB checklist template cross-link), (c) refreshed
+  "Review/ subfolder" entry with watchlist-trigger-met note, (d)
+  new "templates/ subfolder" entry (first customer-facing sales
+  ammunition template), (e) new "celvivo_commercial/ subfolder" entry
+  (the 6-30 quote PDF migration), refreshed the Synthesis-policy
+  section with this run's delta summary. **No `/themes.md` row change**
+  — the new external evidence routes into the existing
+  `class-organoid-3d-bioprinting` theme row (Quintard 2024 is
+  organ-on-chip adjacent to Robin's 4 application domains; Guo 2026
+  is IRB-side adjacent to the same row); the Robin-authored
+  IRB checklist template routes into the existing
+  `/themes/05-robin-research.md` "Sales ammunition pipeline" section
+  rather than a new theme row. **No `/open-questions.md` row, no
+  `/personal-logistics.md` item** — the IRB checklist is a
+  vendor-anchored customer-training artifact, not a memory-graph
+  uncertainty. (b) `/themes/05-robin-research.md` — vault-snapshot
+  metadata refreshed (fetch timestamp → `2026-08-17T18:09:32Z`,
+  raw-manifest path → the new `2026-08-17T18-09-32-895Z` manifest;
+  vault HEAD `297f106d` → `a4fa5a32`; untracked-dir set refreshed
+  with `celvivo_commercial/` + `templates/` entries; `04-Literature/Deep-Reads/Organoid/`
+  count `659` → `661` (Quintard + Guo); 30-day research output
+  table extended with the 2026-08-16 Quintard 2024 + Guo 2026 row;
+  by-vendor table extended with `Microfluidic / organ-on-chip
+  adjacent` and `Ethics / IRB` rows; Sales ammunition pipeline section
+  extended with the `templates/类器官IRB申请清单.md` IRB checklist
+  template). (c) `/themes/01-organoid-equipment.md` — Quintard 2024
+  added to CelVivo evidence anchors (CelVivo ClinoStar rating 3
+  upstream workflow step) and Guo 2026 added to the Regulatory /
+  China-specific context section (CelVivo ClinoStar rating 4 IRB
+  compliance ammunition; companion to the existing CDE classification
+  + Order No. 818 items). (d) `/sources/literature.md` — Quintard 2024
+  + Guo 2026 added to the 30-day deep-read index. (e) `/sources/README.md`
+  — git-repo last-updated refreshed from `2026-08-15 18:07 UTC` to
+  `2026-08-17 18:09 UTC`. (f) `/quickstart.md` — added the
+  "Latest update — git-repo-1 (2026-08-17T18:09Z)" paragraph. Wiki-side: **4 new wiki commits** landed (`021e929` daily
   update 2026-08-14 + `6258717` sources-sync 2026-08-14 + `173b58c`
   daily update 2026-08-15 + `2507925` sources-sync 2026-08-15),
   advancing HEAD from `1737454` (2026-08-13) to `2507925` (2026-08-15).
diff --git a/sources/hackernews.md b/sources/hackernews.md
index 19ed8b5..e4727cd 100644
--- a/sources/hackernews.md
+++ b/sources/hackernews.md
@@ -2,7 +2,7 @@
 type: "Reference"
 title: "Hacker News — evidence index"
 description: "Compact evidence trail for the Hacker News connector (hackernews-1, Robin-curated life-sciences + AI workflow). Synthesis lives on /themes.md, /commitments.md, etc.; this page only records ingestion coverage and notable items."
-tags: [hackernews, evidence-index, source, 2026-08-16, 2026-08-15, 2026-08-13, 2026-08-12, 2026-08-10]
+tags: [hackernews, evidence-index, source, 2026-08-17, 2026-08-16, 2026-08-15, 2026-08-13, 2026-08-12, 2026-08-10]
 ---
 
 # Hacker News — evidence index
@@ -15,10 +15,42 @@ Compact evidence trail for the Hacker News connector (`hackernews-1`, Robin-cura
 - **Backend:** public HN feeds (`top`, `new`) + Algolia HN search queries
 - **Auth:** none — public feeds
 - **Window:** last 24 hours
-- **Latest fetch:** `2026-08-16T18:00:39Z` (LLM-agent topic set: `organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents` — 6 queries; the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories" is the active query set; prior 2026-08-15 18:00, 2026-08-13 18:00, 2026-08-12 18:00, 2026-08-10 18:00, 2026-08-08 18:00, 2026-08-08 03:15, 2026-08-07 12:29, 2026-08-03 18:00, 2026-08-02 18:00, 2026-08-01 18:00, 2026-07-31 18:00, 2026-07-30 18:00, 2026-07-29 18:00, 2026-07-28 18:00, 2026-07-27 18:00, 2026-07-26 18:16 and 18:00 pulls also documented below)
-- **Raw dumps:** `~/.openwiki/connectors/hackernews/raw/2026-08-16T18-00-02-618Z/hackernews-results.json` (current — fifth consecutive fully-zero Algolia lane pull since 2026-08-07; two adjacents worth flagging for traceability: `49316271` Anthropic multi-agent systems research + `49319814` Show HN shared-memory public AI, see 2026-08-16 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-15T18-00-02-001Z/hackernews-results.json` (prior — fourth consecutive fully-zero Algolia lane pull since 2026-08-07; one high-engagement Robin-stack-adjacent: `49309549` Auto-research with codex 232x Faster Kernel, see 2026-08-15 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-13T18-00-02-662Z/hackernews-results.json` (prior — one directly-relevant `agent-memory-architecture` evidence (MCP Memory using OKF), see 2026-08-13 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-12T18-00-01-956Z/hackernews-results.json` (prior — one new low-engagement organoid signal, see 2026-08-12 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-10T18-00-02-327Z/hackernews-results.json` (prior — no promotable hits, see 2026-08-10 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-08T18-00-01-989Z/hackernews-results.json` (prior — no promotable hits, see 2026-08-08 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-08T03-14-40-856Z/hackernews-results.json` (prior — no promotable hits, see 2026-08-08 03:15 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-07T12-29-44-173Z/hackernews-results.json` (prior — no promotable hits, see 2026-08-07 entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-03T18-00-02-766Z/hackernews-results.json` (earlier — material findings, see 2026-08-03 entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-02T18-00-02-278Z/hackernews-results.json` (empty) · `~/.openwiki/connectors/hackernews/raw/2026-08-01T18-00-02-274Z/hackernews-results.json` (empty) · `~/.openwiki/connectors/hackernews/raw/2026-07-31T18-00-02-519Z/hackernews-results.json` (empty) · `~/.openwiki/connectors/hackernews/raw/2026-07-30T18-00-02-784Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-29T18-00-02-667Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-28T18-00-02-178Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-27T18-00-02-615Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-26T18-16-06-805Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-26T18-00-02-441Z/hackernews-results.json`
+- **Latest fetch:** `2026-08-17T18:00:31Z` (LLM-agent topic set: `organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents` — 6 queries; the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories" is the active query set; prior 2026-08-16 18:00, 2026-08-15 18:00, 2026-08-13 18:00, 2026-08-12 18:00, 2026-08-10 18:00, 2026-08-08 18:00, 2026-08-08 03:15, 2026-08-07 12:29, 2026-08-03 18:00, 2026-08-02 18:00, 2026-08-01 18:00, 2026-07-31 18:00, 2026-07-30 18:00, 2026-07-29 18:00, 2026-07-28 18:00, 2026-07-27 18:00, 2026-07-26 18:16 and 18:00 pulls also documented below)
+- **Raw dumps:** `~/.openwiki/connectors/hackernews/raw/2026-08-17T18-00-01-808Z/hackernews-results.json` (current — sixth pull since 2026-08-07 to have either a fully-zero or fully-noise Algolia lane (organoid/3Brain/Cellink each returned nbHits=6 string-collision noise; CelVivo/openwiki/deepagents each returned nbHits=0); two adjacents worth flagging for traceability: `49323381` Stripe acquires OpenRouter for $7B+ + `49331423` AI-Generated Copilot "Autofix" Snowflake Jira security incident, see 2026-08-17 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-16T18-00-02-618Z/hackernews-results.json` (prior — fifth consecutive fully-zero Algolia lane pull since 2026-08-07; two adjacents worth flagging for traceability: `49316271` Anthropic multi-agent systems research + `49319814` Show HN shared-memory public AI, see 2026-08-16 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-15T18-00-02-001Z/hackernews-results.json` (prior — fourth consecutive fully-zero Algolia lane pull since 2026-08-07; one high-engagement Robin-stack-adjacent: `49309549` Auto-research with codex 232x Faster Kernel, see 2026-08-15 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-13T18-00-02-662Z/hackernews-results.json` (prior — one directly-relevant `agent-memory-architecture` evidence (MCP Memory using OKF), see 2026-08-13 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-12T18-00-01-956Z/hackernews-results.json` (prior — one new low-engagement organoid signal, see 2026-08-12 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-10T18-00-02-327Z/hackernews-results.json` (prior — no promotable hits, see 2026-08-10 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-08T18-00-01-989Z/hackernews-results.json` (prior — no promotable hits, see 2026-08-08 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-08T03-14-40-856Z/hackernews-results.json` (prior — no promotable hits, see 2026-08-08 03:15 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-07T12-29-44-173Z/hackernews-results.json` (prior — no promotable hits, see 2026-08-07 entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-03T18-00-02-766Z/hackernews-results.json` (earlier — material findings, see 2026-08-03 entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-02T18-00-02-278Z/hackernews-results.json` (empty) · `~/.openwiki/connectors/hackernews/raw/2026-08-01T18-00-02-274Z/hackernews-results.json` (empty) · `~/.openwiki/connectors/hackernews/raw/2026-07-31T18-00-02-519Z/hackernews-results.json` (empty) · `~/.openwiki/connectors/hackernews/raw/2026-07-30T18-00-02-784Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-29T18-00-02-667Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-28T18-00-02-178Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-27T18-00-02-615Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-26T18-16-06-805Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-26T18-00-02-441Z/hackernews-results.json`
 
-## Latest update — 2026-08-16 18:00 UTC
+## Latest update — 2026-08-17 18:00 UTC
+
+- **Coverage:** 2 feeds (`top`, `best`), 6 search queries (the same simplified LLM-agent topic set from the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories": `organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents`). `top` feed returned 26 items, `best` feed returned 17; deduplication gave **34 unique items across both feeds** (9 overlap: `49324985` Qwen 3.8 27B, `49324087` Anthropic Claude watermarks, `49330781` DuckDB v2.0, `49326816` Linear algebra, `49325789` AI regulation, `49325061` Reticulum, `49329575` GPT 5.6 Sol, `49330597` GitHub incident, `49323686` Nvidia/OpenAI infra reduction). The 6-query lane produced the hit table below; the connector completed normally at `fetchedAt: 2026-08-17T18:00:31.353Z` (24-hour window).
+- **Life-science lane:** **zero vendor-anchored hits across all four named vendor queries — Algolia returned nbHits>0 only as string-collision noise.** The pattern matches the 2026-08-10 + 2026-08-12 pulls (noise-only on substring fragments) rather than the 2026-08-08 03:15 + 2026-08-08 18:00 + 2026-08-13 + 2026-08-15 + 2026-08-16 pulls (clean zero). Specifically: `organoid` returned `nbHits=6` — all string-collision noise on the "organi-" substring (`49333633` EFF organizations, `49333041` Google Maps "organic mode", `49331551` Saggar terminal "organized", `49331243` SaaS mockup "organization", `49328016` "organised" coding benchmark, `49327500` "organization" productivity essay). `CelVivo` returned `nbHits=0` (clean zero). `3Brain` returned `nbHits=6` — all string-collision noise on the "brain" / author-substring (`49331883` "Future of the Brain" 2005 video, `49331363` MIT "Flexible brain circuits can switch between different tasks" 2pts, `49329122` "brainless" author on Knowledge Graph article, `49328432` "brain protection" device article, `49327500` "brainbattler" productivity blog, `49327395` Columnary Chrome extension with "brain" in body). `Cellink` returned `nbHits=6` — all string-collision noise on substrings "calling"/"celine"/"ceiling"/"welling" (`49333633` EFF "calling", `49332326` Agent Mesh body-text "calling" — see flag-for-traceability note below, `49330671` Deepseek Harness Plugin author "celineycn", `49327308` "ceiling" in Ask HN, `49323983` "Wellington" bookstore, `49322618` tennis "calling"). `openwiki` returned `nbHits=0` (clean zero). `deepagents` returned `nbHits=0` (clean zero). A title/URL regex sweep across the 34 unique top+best items also turned up zero organoid / 3D-bioprinting / CelVivo / 3Brain / Cellink / ClinoStar / ClinoReactor / MEA / spheroid / organ-on-chip items. The "no material HN footprint for the 4 vendor lines" finding continues to hold — this is the **sixth pull since 2026-08-07 to have an empty / noise-only Algolia lane on vendor queries** (after the 2026-08-08 03:15 + 2026-08-08 18:00 + 2026-08-13 + 2026-08-15 + 2026-08-16 fully-zero pulls; the 2026-08-10 + 2026-08-12 pulls also returned noise-only on the substring queries). The Tavily web-search lane remains the better signal for vendor news.
+- **Workflow lane:** **zero positive `openwiki` brand hits; zero `deepagents` hits.** `openwiki` and `deepagents` both returned `nbHits=0` — so the `openwiki-brand` watchlist row on `/themes.md` stays at Last seen 2026-07-16 and the `agent-memory-architecture` adjacency note for "OpenWiki brand signal" stays at Last seen 2026-07-29. The 34 unique top+best items include **no directly-relevant item for any `/themes.md` row** but include **two adjacent items worth flagging for traceability** — plus several higher-engagement items that fall outside Robin's 4 application domains (3D cell culture, 3D bioprinting, neuroscience in vitro, organoid workflows) and the named-stack scope (Hermes / MiniMax / OpenWiki / RAGFlow / NocoDB / SeaFile / Codex CLI). The two adjacents stay adjacent-not-promoted under the brief's "low-engagement items are watchlist by default; promotion requires recurrence, strong engagement, or corroboration" rule **and** the `/themes.md` scope discipline:
+  - **`49323381` "Stripe will reportedly acquire OpenRouter for $7B+"** (439 pts, 271 cmts, **best feed**, by `zacharyozer` 2026-08-16, https://techcrunch.com/2026/08/16/stripe-will-reportedly-acquire-ai-gateway-startup-openrouter-for-7b/). TechCrunch report on Stripe's reported $7B+ acquisition of OpenRouter, the AI model-routing gateway that aggregates DeepSeek / Qwen / Google / OpenAI / Anthropic / Mistral / Cohere / Perplexity / MiniMax-M3-adjacent models under one inference API. **Strongest single business event in the broader AI inference lane this pull** — the 439-pt + 271-cmt engagement makes it the highest-engagement business-side signal on this pull after the Qwen 3.8 27B Simon Willison blog (which is open-weight). Strong topical fit to the `MiniMax-m3` row's competitive-benchmarks lane (OpenRouter is a primary MiniMax-adjacent inference provider alongside the direct MiniMax-M3 HuggingFace + Tweet launch points), and to the AI-agent-inference supply chain that Robin's Hermes Agent stack sits in. **However** (a) Stripe acquiring OpenRouter is a **payment-processor + routing-gateway acquisition**, not a change to Hermes / MiniMax / OpenWiki / Codex CLI / RAGFlow / NocoDB / SeaFile directly; (b) the established scope rule on inference-provider business events keeps them adjacent-not-promoted unless there is a direct change to Hermes / MiniMax / OpenWiki / Codex CLI itself (per the 2026-07-30 / 2026-08-03 / 2026-08-10 / 2026-08-12 / 2026-08-13 / 2026-08-15 / 2026-08-16 traceability entries); (c) the established "open-weight AI never earns a `themes.md` row" scope rule would apply if OpenRouter were itself open-weight, but OpenRouter is a commercial gateway — the rubric remains "stay adjacent because not on Robin's named stack". **Adjacent-not-promoted** per scope. The 439-pt + 271-cmt engagement is high enough to surface in any HN digest even if the finding is not promoted. **No commitment row** — Robin does not currently use OpenRouter as a primary inference path (his Hermes Agent stack uses direct MiniMax API + unsloth/MiniMax-M3-GGUF local-LLM path documented on the `/themes.md` `MiniMax-m3` row); if a Hermes / MiniMax-side response to the Stripe-OpenRouter deal surfaces on a future pull (e.g. MiniMax changing its MiniMax-API pricing terms in response to the acquisition, or a Hermes v0.19 / v0.20 patch release noting OpenRouter as a supported inference path), this becomes the first corroborating event for an `MiniMax-m3-row-annex-inference-routing-changes` annex on the existing row.
+  - **`49331423` "AI-Generated GitHub Copilot 'Autofix' Allowed Compromise of Snowflake's Jira"** (168 pts, 81 cmts, **top feed**, by `galnagli` 2026-08-17, https://www.wiz.io/blog/red-agent-snowflake-copilot-cicd-bug). Wiz research write-up on a **production security incident** in which an AI-generated code suggestion from GitHub Copilot's "Autofix" feature (the agentic self-fix tool inside GitHub Copilot) was allowed to merge into Snowflake's CI/CD pipeline and **compromised Snowflake's Jira instance**. The 168-pt + 81-cmt engagement is high enough to surface in any HN digest. **This is the strongest agent-supply-chain / agent-tool-use security incident** to surface on HN top since the 2026-07-30 pull's `49214468` "Managing AI Coding Costs at Scale" Databricks blog (290 pts best — adjacent-only, off-scope). Strong topical fit to Robin's broader Hermes Agent / Codex CLI / OpenWiki agent-tool-use lane — Hermes Agent v0.19 Quicksilver's live subagent feature performs tool-use calls to filesystem / shell / API tools with user-confirmation gates (per [`/themes/03-ai-agents.md`](/themes/03-ai-agents.md)), and the Copilot Autofix → Snowflake Jira incident is the **canonical 2026-08 working example** of agent-generated code reaching production with a security-bypass. **However** (a) this is a **GitHub Copilot incident**, not a Hermes Agent / MiniMax / OpenWiki / Codex CLI incident; (b) the established scope rule on non-named-stack agent-security incidents keeps them adjacent-not-promoted unless there is a direct incident at a vendor in Robin's named stack; (c) the brief's "Workflow tooling priority LOW — surface story-worthy changes only" rule does not promote this to a `/themes.md` row by itself, though it does match the established "watchlist on agent-supply-chain security signals" pattern. **Adjacent-not-promoted** per scope. The 168-pt + 81-cmt engagement is high enough to surface in any HN digest. **No commitment row** — Robin does not use GitHub Copilot Autofix on the named stack (Hermes Agent's tool-use gates + Codex CLI's command-confirmation flow are the two agent surfaces that handle tool-use safety; if Hermes v0.21 / v0.20 patch release adds an explicit AI-coding-cost-supply-chain audit hook in response to the broader Copilot Autofix incident, that becomes a future-promotable commitment on `/commitments.md`).
+  - **`49332326` "Show HN: Agent Mesh – Shared memory for multi-Agent coordination"** (1 pt, top feed, by `balgeman` 2026-08-17, https://github.com/cbalgeman/agent-mesh). Show HN surfacing for a "Human + multi-Agent shared memory system" — uses **SQLite for Agent Mail** (Agent-to-Agent message bus keyed by request/response id), a **decision log** keyed on id (mirrors the Karpathy LLM Wiki pattern of structured IDs in code comments / plan docs), a **Workbench dashboard** (web UI for tracking logs), and a **Claude app + CODEX via `codex exec` agent-mesh bridge** with **all decision modifications requiring Human approval from the Workbench**. Architectural pattern fits the broader `agent-memory-architecture` theme at the macro level (shared memory + decision log + agent-coordination + human-approval gate) — same broad lane as the OKF / MCP Memory / Karpathy LLM Wiki / MinIO AIStor Memory / Exabase BEAM cluster. **However** (a) the implementation uses SQLite + ids + workbench dashboard rather than OKF frontmatter (no `okf_version: "0.1"` reference in the README), so it doesn't corroborate the existing row's OKF+memory schema pattern (the criterion that drove the 2026-08-13 MCP Memory / Google's OKF Last-seen refresh); (b) 1-pt engagement is too low for a theme-row Last-seen refresh per the established "Watchlist promotion requires recurrence, strong engagement, or corroboration" rule (1 pt is well below the 100+ pt threshold for high-engagement vendor releases and below the 46-pt MCP Memory refresh trigger); (c) the item was surfaced by the `Cellink` Algolia query as a string-collision noise hit on the word "calling" in body text — not because it relates to Cellink bioprinters. **Adjacent-not-promoted** per scope. The 1-pt engagement is too low to refresh `agent-memory-architecture` Last seen on the existing row, but the macro-pattern is worth flagging in case a future HN item at higher engagement combines Agent Mesh + OKF frontmatter (or if Agent Mesh itself adds OKF support in a future version). **No commitment row, no open-question row, no `/themes.md` refresh.**
+  - **`49324985` "Qwen 3.8 27B is excellent, but it defaults to overthinking things"** (732 pts, 344 cmts, top+best feed, by `bilsbie`, https://simonwillison.net/2026/Aug/16/qwen-38-27b/). **Highest-engagement item of the pull.** Simon Willison's blog post on Alibaba's Qwen 3.8 27B open-weight model — strong model-quality review with the headline observation that the model "defaults to overthinking" (overly verbose reasoning chains). Strong topical fit to the LLM lane + agent lane (Qwen 3.8 27B is small enough to run on commodity hardware — adjacent to Robin's local-LLM stack at `/themes/04-local-llm.md`). **However** Qwen is open-weight, and the established scope rule ("open-weight AI never earns a `themes.md` row") applies — same rubric as the prior 2026-08-12 pull's `49273478` "Qwen3.8-2.4T-A95B" (200 pts) and `49272534` "Qwen 3.8-27B goes openweight in 2 days" (15 pts), and the 2026-08-10 pull's `49274950` "Qwen3.8-2.4T" (17 pts). The recurrence is real (this is the **third Qwen 3.8× item across three pulls in 7 days**) but per scope discipline the findings stay adjacent-not-promoted. **Adjacent-not-promoted** per brief. The 732-pt engagement is the highest single-item engagement of any HN item since the 2026-08-10 pull's Muse Glimmer (759 pts) — it would qualify for a `themes.md` row if Qwen were on Robin's named stack, but Qwen is open-weight and off-scope. **No commitment row** — Robin's local-LLM stack at `/themes/04-local-llm.md` tracks Ollama / bge-reranker / RAGFlow / LM Studio, and adding Qwen 3.8 27B as a local-LLM candidate is a Robin-workflow decision not yet signaled; if Robin starts running Qwen 3.8 27B locally on a future pull, the existing `/themes/04-local-llm.md` "Backlog" candidate becomes a follow-up.
+  - **`49324087` "Anthropic's 'watermark' text adulteration in Claude is a perversion of writing"** (670 pts, 577 cmts, top+best feed, by `ropbear`, https://daringfireball.net/2026/08/anthropics_watermark_text_adulteration_in_claude_is_a_perversion_of_writing). Daring Fireball essay on Anthropic's Claude text watermarking as a "perversion of writing". Strong engagement (670 pts, 577 cmts). **Adjacent to the Claude / Claude Code lane** (per the 2026-08-13 pull's `49281916` Codex in ChatGPT desktop app for Linux, the 2026-08-10 pull's `49239021` Auto mode default in Claude Code, and the 2026-08-08 18:00 pull's `49215786` Claude Bluetooth-tracking anecdote) but **not** on Robin's named daily-driver stack. Adjacent-not-promoted per scope discipline ("Claude Code wrapper / TUI / usage changes stay adjacent-not-promoted unless there is a direct change to Hermes / MiniMax / OpenWiki / Codex CLI itself" — see the traceability entries below).
+  - **`49323381` Stripe acquires OpenRouter** (already covered above) plus **all other feed items not promoted** (28 items in the 25-pt+ engagement tail) are off-scope per the brief's scope filter — `49330781` "A Preview of DuckDB v2.0" (305 pts, 48 cmts, top+best, https://duckdb.org/2026/08/17/duckdb-20-highlights — DuckDB is a columnar DBMS, adjacent to Robin's SQLite-backed services but on a different DBMS; off-scope); `49330597` "Incident with Github.com" (226 pts, 708 cmts, top, by `SpyCoder77` — GitHub status incident; real-but-incidental exposure on Robin's stack but Robin's primary git is Gitea per `/themes/05-robin-research.md`; flagged for traceability because the 226-pt + 708-cmt engagement is the highest comment count of the pull but the incident is on `github.com` not `gitea`); `49330684` "Incident with Github.com" (691 pts, 2 cmts, best — same GitHub incident from the best feed); `49330632` "GitHub down again? no PR access" (288 pts, 2 cmts, best — Ask HN thread on the same GitHub incident); `49329575` "GPT 5.6 Sol is the best 'vision' model OpenAI ever released" (216 pts, 108 cmts, top+best, by `plurby`, https://blog.roboflow.com/openai-gpt-5-6/ — OpenAI GPT 5.6 Sol vision-model release; off-scope per brief); `49325789` "On AI regulation and messaging" (208 pts, 415 cmts, top+best, by `jacquesm` — Dario Amodei Twitter post on AI regulation; off-scope AI policy); `49326816` "Linear algebra done right" (208 pts, 79 cmts, top+best, https://linear.axler.net/ — math textbook page; off-scope); `49325061` "Reticulum – Decentralized Mesh Network" (205 pts, 65 cmts, top+best — mesh-network open-source project; off-scope); `49323686` "Nvidia dramatically reduces amount of OpenAI infra financing it may guarantee" (236 pts, 137 cmts, best, https://www.reuters.com/business/nvidia-scales-back-250-billion-openai-data-center-guarantee-wsj-reports-2026-08-14/ — Nvidia/OpenAI infrastructure deal reduction; off-scope infrastructure news); `49332981` "Universal Health Coverage Could Save $1T and 114k Lives a Year, Yale Study" (291 pts, 391 cmts, best, https://ysph.yale.edu/news-article/universal-health-coverage-could-save-one-trillion-dollars-and-114000-lives-every-year/ — Yale SPH study on UHC; off-scope clinical health economics); `49325159` "The federal keyword lists that canceled billions in research funding" (267 pts, 159 cmts, best, https://www.highereddive.com/news/inside-the-federal-keyword-lists-that-canceled-billions-in-research-funding/826203/ — research funding policy; off-scope); `49326156` "GIMP Development Update" (245 pts, 225 cmts, best, https://www.gimp.org/news/2026/08/16/dev-update-august-2026/ — GIMP release notes; off-scope graphics); `49322695` "Models Are Getting Dumber on Purpose" (326 pts, 181 cmts, best, https://w4g1.dev/blog/models-are-getting-dumber-on-purpose — AI alignment essay; off-scope); `49331033` "Ask HN: Alternatives to GitHub" (293 pts, 180 cmts, top+best, by `dhruv3006` — Robin's stack uses Gitea primarily per the 2026-08-12 / 2026-08-13 / 2026-08-15 traceability notes; Ask HN discussion, off-scope but adjacent to the ITX 24h host build commitment per `/commitments.md` `itx-24h-host-build-2026-q3`); `49330456` "Online clinics and influencers are promoting Cialis as a longevity drug" (79 pts, 57 cmts, top, https://www.npr.org/2026/08/17/nx-s1-5928263/cialis-viagra-tadalafil-longevity-heart-health — clinical pharmacology news; off-scope); `49332564` "Anthropic's War on open source AI" (64 pts, 21 cmts, top — Twitter thread on Anthropic's relationship to open-source AI; off-scope AI policy); `49331474` "How to put 170 atoms in an atom" (58 pts, 5 cmts, top — chemistry retro; off-scope); `49332751` "Launch HN: Speko (YC S26) – OpenRouter for Voice AI" (52 pts, 23 cmts, top — YC S26 voice-AI router launch at https://speko.ai/; adjacent to the AI-inference lane but voice-specific; off-scope); `49331551` "Show HN: Saggar, a Mac terminal that keeps sessions and your attention organized" (23 pts, 17 cmts, top, by `mcclowes`, https://saggar.marginalutility.dev/ — terminal app; off-scope); `49327643` "Show HN: Desktopcolors.com – A museum for solid background colors of classic OS" (105 pts, 42 cmts, top — design/retro essay; off-scope); `49333932` "Buy Your Friends Batteries" (60 pts, 63 cmts, top — lifestyle essay; off-scope); `49323474` "How I developed an Am29000 C compiler and web browser" (48 pts, 5 cmts, top — retro computing essay; off-scope); `49331555` "The only known trebuchet casualty in history" (49 pts, 13 cmts, top — archaeology essay; off-scope); `49330215` "Show HN: Sokoban AI Solver" (49 pts, 31 cmts, top — Show HN; off-scope); `49330978` "How to ship a database every day" (46 pts, 6 cmts, top — Turbopuffer engineering blog on control plane; off-scope); `49331220` "How to disable or avoid intrusive AI" (130 pts, 54 cmts, top — librarian.net essay; off-scope); `49331222` "Apple's App Tracking Transparency treated its own apps better than rivals" (195 pts, 70 cmts, top — Bundeskartellamt news on Apple ATT; off-scope); `49331288` "Show HN: Learn Flags Quiz" (27 pts, 13 cmts, top — Show HN; off-scope); `49330671` "Show HN: Deepseek Harness Plugin - Turn DS into Trading Analyst" (2 pts, 0 cmts, top — Show HN trading plugin; off-scope); `49333824` "Sun Clock" (12 pts, 5 cmts, top — Show HN; off-scope). Engagement range 1–732 pts across the 34 unique items; **3 items match a Robin in-scope keyword** (organoid / 3Brain / Cellink in the Algolia query lane — all string-collision noise), **2 items match Robin's broader agent-stack lane** (Stripe/OpenRouter + Copilot Autofix), and **1 item matches the broader AI-agent-memory architecture lane** (Agent Mesh at 1 pt). Per the brief: low-engagement items stay watchlist by default; only high-engagement + directly-relevant items earn promotion. None of the 34 unique items crosses the promotion threshold.
+- **Synthesis result:** **no theme refresh, no commitment row, no open-question row, no personal-logistics item.** The `class-organoid-3d-bioprinting` row on `/themes.md` stays at Last seen 2026-08-12 (no organoid item — the 6 organoid Algolia hits are all string-collision noise). The `agent-memory-architecture` row stays at Last seen 2026-08-13 (the `49332326` Agent Mesh 1-pt Show HN is too low-engagement to refresh Last seen per the established "Watchlist promotion requires recurrence, strong engagement, or corroboration" rule, and the implementation uses SQLite + decision log rather than OKF frontmatter). The `MiniMax-m3` row stays at Last seen 2026-08-03 (no MiniMax model release; `49323381` Stripe-OpenRouter is an upstream business event, not a MiniMax change). The `hermes-agent-v0-19-quicksilver` row stays at Last seen 2026-08-03 (no Hermes Agent release; `49331423` Copilot Autofix is a GitHub Copilot incident, not a Hermes Agent incident). The `openwiki-brand` watchlist row stays at Last seen 2026-07-16 (no positive `openwiki` hits). All three flag-for-traceability items stay adjacent-not-promoted under the existing scope discipline. **Key calls**: 
+  - **`49323381` Stripe acquires OpenRouter for $7B+** (439 pts, 271 cmts) is the **strongest single business event in the AI inference lane this pull** — the $7B+ acquisition value is the largest AI-infrastructure deal on this pull and the OpenRouter-as-MiniMax-adjacent inference-provider angle is the cleanest single touchpoint to Robin's Hermes Agent / MiniMax-M3 stack since the 2026-07-30 Tavily Hermes Agent API server documentation refresh. Adjacent-not-promoted per scope (Stripe + OpenRouter are not on Robin's named stack), but flagged here because (a) the 439-pt + 271-cmt engagement is high enough to surface in any HN digest; (b) the OpenRouter-MiniMax adjacency is the most concrete inference-routing change in the public AI lane since the 2026-08-03 MiniMax-H3 launch cluster; and (c) any Hermes / MiniMax-side response on a future pull (e.g. MiniMax updating its API-pricing terms in response to the acquisition, or Hermes adding OpenRouter as a named inference provider) becomes a `MiniMax-m3` row annex candidate.
+  - **`49331423` AI-Generated Copilot "Autofix" Allowed Compromise of Snowflake's Jira** (168 pts, 81 cmts) is the **strongest agent-supply-chain / agent-tool-use security incident** to surface on HN top since the 2026-07-30 Databricks "Managing AI Coding Costs at Scale" (290 pts best) adjacent-only item. Adjacent-not-promoted per scope (GitHub Copilot incident, not a Hermes / MiniMax / OpenWiki incident), but flagged here because (a) the Snowflake Jira production compromise via an AI-generated code suggestion is the canonical 2026-08 working example of agent-tool-use reaching production with a security bypass; (b) Hermes Agent v0.19 Quicksilver's live subagent feature (per [`/themes/03-ai-agents.md`](/themes/03-ai-agents.md)) and Codex CLI's `codex exec` command-confirmation flow are the two agent surfaces on Robin's named stack that handle tool-use, so any future Hermes / Codex-side response to the broader Copilot Autofix incident is a `themes.md` row annex candidate for `hermes-agent-v0-19-quicksilver`.
+  - **`49332326` Agent Mesh – Shared memory for multi-Agent coordination** (1 pt, Show HN) is the **first HN item this year to surface an explicit "shared memory + decision log + human-approval gate" architecture** that mirrors the `agent-memory-architecture` theme at the macro level — adjacent-not-promoted because (a) 1-pt engagement is below the established refresh threshold; (b) the implementation uses SQLite + ids rather than OKF frontmatter (the row's anchor schema); (c) it was surfaced as a string-collision noise hit on the `Cellink` Algolia query (word "calling" in body text), not because it relates to Cellink bioprinters. Flagged for traceability because (a) the architecture pattern (Human + multi-Agent shared memory + SQLite message bus + decision log + Workbench dashboard + Claude + CODEX via `codex exec` + all decision modifications require Human approval) is a new exact match on the `agent-memory-architecture` macro-pattern; (b) if a future HN item at higher engagement combines the Agent Mesh pattern with explicit OKF frontmatter reference, both items become corroborating evidence for a `themes.md` refresh.
+  - **This is the sixth pull since 2026-08-07 to have an empty / noise-only Algolia lane on vendor queries** (after 2026-08-08 03:15 fully-zero + 2026-08-08 18:00 fully-zero + 2026-08-13 fully-zero + 2026-08-15 fully-zero + 2026-08-16 fully-zero; the 2026-08-10 + 2026-08-12 pulls were also noise-only on the substring queries). The pattern confirms that the empty-pulls-on-vendor-queries cadence is normal under the 6-query LLM-agent topic set — not an outage, no config-side intervention needed. The Tavily (web-search) lane remains the productive lane for vendor news; the HN lane's stable role is now "high-engagement inference-lane adjacents (Stripe/OpenRouter) + agent-stack security adjacents (Copilot Autofix) + show-HN agent-memory architecture watchlist (Agent Mesh) + life-science application-domain watchlist items (organoid / neuroscience / Wired features)" rather than vendor-direct signals. The 9-overlap dedup count between `top` and `best` (34 unique from 26+17) is the highest overlap ratio since the 2026-08-15 pull (4 overlap → 19 unique from 19+4) — the new `best` feed is contributing more deduped items, which is consistent with the higher weekday-evening HN front-page density than the 2026-08-15 Friday-afternoon pull.
+
+| Query lane | Queries run | Qualifying results |
+| --- | --- | --- |
+| Life sciences / vendors | `organoid`, `CelVivo`, `3Brain`, `Cellink` | 0 (`organoid` → 6 noise hits on "organi-" substring; `CelVivo` → 0; `3Brain` → 6 noise hits on "brain" substring; `Cellink` → 6 noise hits on "calling" / "ceiling" / "celine" / "welling" substrings) |
+| AI workflow | `openwiki`, `deepagents` | 0 (both queries returned `nbHits=0`) |
+
+Raw dump: `~/.openwiki/connectors/hackernews/raw/2026-08-17T18-00-01-808Z/hackernews-results.json`.
+
+### Flag-for-traceability: Stripe acquires OpenRouter, AI-generated Copilot Autofix Snowflake Jira compromise, Qwen 3.8 27B on Simon Willison, Agent Mesh shared-memory Show HN — adjacent, off-scope
+
+- **49323381** (439 pts best, 271 cmts) **Stripe will reportedly acquire OpenRouter for $7B+** — TechCrunch (https://techcrunch.com/2026/08/16/stripe-will-reportedly-acquire-ai-gateway-startup-openrouter-for-7b/, by `zacharyozer`). **Strongest single business event in the broader AI inference lane this pull**, on the same 2026-08-16 weekday evening as the Qwen 3.8 27B Simon Willison blog (49324985). OpenRouter is the AI model-routing gateway that aggregates DeepSeek / Qwen / Google / OpenAI / Anthropic / Mistral / Cohere / Perplexity / other vendor models under one inference API — it is a primary MiniMax-adjacent inference provider alongside the direct MiniMax-M3 HuggingFace + Tweet launch points documented on `/themes.md` `MiniMax-m3` row. Stripe is a payment-processor acquiring an AI-infrastructure gateway. The 439-pt + 271-cmt engagement makes this the highest-engagement business-side signal on this pull after the 732-pt Qwen 3.8 27B item. **Adjacent-not-promoted** per scope because (a) Stripe + OpenRouter are not on Robin's named daily-driver stack (Hermes / MiniMax-M3+H3 / OpenWiki / RAGFlow / NocoDB / SeaFile / Codex CLI); (b) the established scope rule on inference-provider business events keeps them adjacent-not-promoted unless there is a direct change to Hermes / MiniMax / OpenWiki / Codex CLI itself (per the 2026-07-30 / 2026-08-03 / 2026-08-10 / 2026-08-12 / 2026-08-13 / 2026-08-15 / 2026-08-16 traceability entries); (c) although OpenRouter is not open-weight, the rubric "inference-provider changes only refresh `themes.md` when there is a direct change to Hermes / MiniMax / OpenWiki / Codex CLI itself" still applies — the acquisition is an upstream business event, not a vendor-stack change Robin acts on. **No commitment row** — Robin does not currently use OpenRouter as a primary inference path; if Robin adopts OpenRouter as a fallback inference provider on a future pull, or if a Hermes / MiniMax-side response to the acquisition surfaces (MiniMax changing its pricing terms in response, or Hermes adding OpenRouter as a named inference path), that becomes a `MiniMax-m3-row-annex-inference-routing-changes` candidate.
+- **49331423** (168 pts top, 81 cmts) **AI-Generated GitHub Copilot "Autofix" Allowed Compromise of Snowflake's Jira** — Wiz research blog (https://www.wiz.io/blog/red-agent-snowflake-copilot-cicd-bug, by `galnagli`). **Strongest agent-supply-chain / agent-tool-use security incident** to surface on HN top this year — a production security incident in which an AI-generated code suggestion from GitHub Copilot's "Autofix" (agentic self-fix) feature was allowed to merge into Snowflake's CI/CD pipeline and compromise the Snowflake Jira instance. The 168-pt + 81-cmt engagement is high enough to surface in any HN digest. Strong topical fit to Robin's broader Hermes Agent / Codex CLI / OpenWiki agent-tool-use lane — Hermes Agent v0.19 Quicksilver's live subagent feature performs tool-use calls to filesystem / shell / API tools with user-confirmation gates (per [`/themes/03-ai-agents.md`](/themes/03-ai-agents.md)), and Codex CLI's `codex exec` flow has its own command-confirmation gates. The Copilot Autofix → Snowflake Jira incident is the **canonical 2026-08 working example** of agent-generated code reaching production with a security-bypass in a vendor agent that did not have the right gates. **Adjacent-not-promoted** per scope because (a) the incident is at GitHub Copilot, not Hermes / MiniMax / OpenWiki / Codex CLI / RAGFlow / NocoDB / SeaFile; (b) the established scope rule on non-named-stack agent-security incidents keeps them adjacent-not-promoted unless there is a direct incident at a vendor in Robin's named stack; (c) the brief's "Workflow tooling priority LOW — surface story-worthy changes only" rule does not promote this to a `/themes.md` row by itself. **Adjacent-not-promoted** per scope. The 168-pt + 81-cmt engagement is high enough to surface in any HN digest. **No commitment row** — Robin's Hermes Agent + Codex CLI tool-use flow is already gated by the existing v0.19 Quicksilver configuration; if a future Hermes v0.20 patch / v0.21 release adds an explicit AI-coding-supply-chain audit hook in response to the Copilot Autofix incident on a future pull, that becomes a future-promotable commitment.
+- **49324985** (732 pts top+best, 344 cmts) **Qwen 3.8 27B is excellent, but it defaults to overthinking things** — Simon Willison blog (https://simonwillison.net/2026/Aug/16/qwen-38-27b/, by `bilsbie`). **Highest-engagement item of the pull.** Strong engagement (732 pts, 344 cmts) makes this the highest single-item engagement on any HN pull since the 2026-08-10 Muse Glimmer (759 pts, off-scope open-weight AI). Strong topical fit to the LLM + agent lane (Qwen 3.8 27B is a small-enough model to run on commodity hardware — adjacent to Robin's local-LLM stack at `/themes/04-local-llm.md`). **However** Qwen 3.8× is open-weight, and the established scope rule ("open-weight AI never earns a `themes.md` row") keeps it adjacent-not-promoted. Same rubric as the prior 2026-08-12 pull's `49273478` "Qwen3.8-2.4T-A95B" (200 pts) and `49272534` "Qwen 3.8-27B goes openweight in 2 days" (15 pts), and the 2026-08-10 pull's `49274950` "Qwen3.8-2.4T FP8" (17 pts). This is the **third Qwen 3.8× item across three pulls in 7 days** — a real recurrence pattern, but per scope discipline the findings stay adjacent-not-promoted. The "overthinking" headline observation is also worth flagging because it mirrors a broader 2026-08 LLM-trend observation (per `49270194` / `49272891` / `49329863` "Models Are Getting Dumber on Purpose" earlier in this pull's `best` feed at 326 pts — same theme of "model vendor intentional behaviour change in 2026-08 surfaces"). **Adjacent-not-promoted** per scope. **No commitment row** — Robin's local-LLM stack at `/themes/04-local-llm.md` tracks Ollama / bge-reranker / RAGFlow / LM Studio, and adding Qwen 3.8 27B as a local-LLM candidate is a Robin-workflow decision not yet signaled; if Robin starts running Qwen 3.8 27B locally on a future pull, the existing `/themes/04-local-llm.md` "Backlog" candidate becomes a follow-up.
+- **49324087** (670 pts top+best, 577 cmts) **Anthropic's 'watermark' text adulteration in Claude is a perversion of writing** — Daring Fireball essay (https://daringfireball.net/2026/08/anthropics_watermark_text_adulteration_in_claude_is_a_perversion_of_writing, by `ropbear`). Highest-comment-count essay of the pull. Strong topical fit to the Claude / Claude Code / Claude watermarking lane. Adjacent to the 2026-08-13 Codex in ChatGPT Linux desktop app + 2026-08-10 Auto mode default in Claude Code + 2026-08-08 Claude Bluetooth-tracking cluster, but **not** on Robin's named daily-driver stack. **Adjacent-not-promoted** per scope discipline ("Claude Code wrapper / TUI / usage changes stay adjacent-not-promoted unless there is a direct change to Hermes / MiniMax / OpenWiki / Codex CLI itself").
+- **49332326** (1 pt top, `Cellink` Algolia noise hit) **Show HN: Agent Mesh – Shared memory for multi-Agent coordination** — Show HN (https://github.com/cbalgeman/agent-mesh, by `balgeman`). Architectural pattern: Human + multi-Agent shared memory; SQLite Agent Mail (Agent-to-Agent message bus keyed on request/response id); decision log (keyed on id, mirrors the Karpathy LLM Wiki pattern of structured IDs in code comments / plan docs); Workbench web dashboard; Claude app + CODEX via `codex exec` agent-mesh bridge; all decision modifications require Human approval from the Workbench. Strong macro-pattern fit to the `agent-memory-architecture` theme at the macro level (shared memory + decision log + agent-coordination + human-approval gate) — same broad lane as OKF / MCP Memory / Karpathy LLM Wiki / MinIO AIStor Memory / Exabase BEAM. **However** (a) implementation uses SQLite + ids + workbench dashboard rather than OKF frontmatter (no `okf_version: "0.1"` reference), so it does not corroborate the existing row's OKF+memory schema pattern (the criterion that drove the 2026-08-13 MCP Memory / Google's OKF Last-seen refresh); (b) 1-pt engagement is well below the established refresh threshold of the prior MCP Memory (46 pts) and below the 100+ pts threshold for high-engagement vendor releases; (c) surfaced as a `Cellink` Algolia query string-collision noise hit on the word "calling" in body text — not because it relates to Cellink bioprinters. **Adjacent-not-promoted** per scope. **No commitment row, no open-question row, no `/themes.md` row refresh** — but flagged for traceability because (a) the macro-pattern (Human + multi-Agent + SQLite message bus + decision log + Workbench + Claude + CODEX via `codex exec` + Human-approval gate) is an exact match on the row's macro-pattern; (b) if a future HN item at higher engagement combines the Agent Mesh pattern with explicit OKF frontmatter reference, both items become corroborating evidence for a `themes.md` refresh.
+
+## Update — 2026-08-16 18:00 UTC
 
 - **Coverage:** 2 feeds (`top`, `best`), 6 search queries (the same simplified LLM-agent topic set from the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories": `organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents`). `top` feed returned 19 unique resolved items, `best` feed returned 12; deduplication gave **25 unique items across both feeds** (6 overlap: `49313428` Super El Niño, `49314235` Cultivating a state of mind, `49314902` Software Engineering fundamentals, `49319389` Research papers using "kidney disappointment", `49319556` Claude System Prompts, `49319633` Firefox for iOS native adblocker). The 6-query lane produced the hit table below; the connector completed normally at `fetchedAt: 2026-08-16T18:00:39.120Z` (24-hour window).
 - **Life-science lane:** **zero vendor-anchored hits across all four named vendor queries.** All six Algolia searches (`organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents`) returned `nbHits=0` in the 24 h window. A title/URL regex sweep across the 25 unique top+best items also turned up zero organoid / 3D-bioprinting / CelVivo / 3Brain / Cellink / ClinoStar / ClinoReactor / MEA / spheroid / organ-on-chip items. The "no material HN footprint for the 4 vendor lines" finding continues to hold — this is the **fifth pull since 2026-08-07 to have a fully-zero Algolia lane** (after the 2026-08-08 03:15 + 2026-08-08 18:00 + 2026-08-13 + 2026-08-15 pulls; the 2026-08-10 + 2026-08-12 pulls had Algolia hits that were all string-collision noise rather than fully-zero). The Tavily web-search lane remains the better signal for vendor news.
diff --git a/sources/index.md b/sources/index.md
index ff0c198..cb03adf 100644
--- a/sources/index.md
+++ b/sources/index.md
@@ -4,7 +4,7 @@
 - [Agents 代理商档案索引 — 跨 agent CRM 同步](agents.md) - Cross-agent index of the Obsidian vault 02-Clients/Agents/* profiles (which agents Robin is actively working with, mapped by vendor product line). Base identity only — sensitive fields (phone / WeChat / email / end-customer list / opportunity value) live only in the private vault. Updated 2026-08-07 with _known_associations.md product-line → agent → end-customer mapping.
 - [全国经销商地图 (2026-08-07 时点)](distributors-china-2026.md) - Compact index of Robin's 2026-08-07 China distributor baseline (259 dealers across 7 regions, replacing 261 in the 2026-07-24 baseline) plus the new product-association index _known_associations.md. Surfaces CelVivo ClinoStar → 济南成全 + FemtoBiomed CellShot → 9X Bio → TriArm Therapeutics chain. Routes pricing-sensitive fields to the private Obsidian vault per /sources/agents.md privacy rule.
 - [飞书邮箱 (Robin customer mailbox)](feishu-mail.md) - Planned cross-agent mailbox sync target for Robin's Feishu (飞书) mailbox (imap.feishu.cn:993 / imap.larksuite.com:993) — would let MiniMax code / Hermes recall 'what did Robin last discuss with customer X' from email metadata + summaries. Not yet provisioned — IMAP credentials + update script + crontab still pending Robin setup; this page documents the planned configuration and the sync policy that will be applied once provisioned.
-- [Git repo — evidence index (Obsidian vault, Robin)](git-repo.md) - Compact manifest of Robin's Obsidian vault + the local OpenWiki wiki, ingested through the local git-repo connector. Two configured repos: obsidian-vault at /home/ldw/workspace (main branch, HEAD 297f106d, 2026-08-12, unchanged across the 2026-08-13 / 2026-08-15 fetches) and openwiki-wiki at /home/ldw/.openwiki/wiki (main branch, HEAD 2507925, 2026-08-15). This page is a navigation index — content ingestion (paper deep reads, sales scripts, customer files) happens via the Hermes skill and RAGFlow, not here.
+- [Git repo — evidence index (Obsidian vault, Robin)](git-repo.md) - Compact manifest of Robin's Obsidian vault + the local OpenWiki wiki, ingested through the local git-repo connector. Two configured repos: obsidian-vault at /home/ldw/workspace (main branch, HEAD a4fa5a32, 2026-08-16, 7 new vault commits in the 2026-08-15T18:07Z → 2026-08-17T18:09Z 48-hour window) and openwiki-wiki at /home/ldw/.openwiki/wiki (main branch, HEAD be49285, 2026-08-17). This page is a navigation index — content ingestion (paper deep reads, sales scripts, customer files) happens via the Hermes skill and RAGFlow, not here.
 - [Hacker News — evidence index](hackernews.md) - Compact evidence trail for the Hacker News connector (hackernews-1, Robin-curated life-sciences + AI workflow). Synthesis lives on /themes.md, /commitments.md, etc.; this page only records ingestion coverage and notable items.
 - [文献精读 Master Template (Robin 7-27 实战版, "真适合浏览" 1 文件)](ldr-report-template.md) - Master template for Robin's literature-deep-read (LDR) pipeline — consolidates 4 literature skills (`literature-deep-read` / `research` / `review` / `curation-for-sales`) into a single 8-rule + 3-trigger + 5-section "真适合浏览" report format. Synthesized from 4-27 SOP范本 + 7-27 实战 lessons (Tasevska / Raji / Bosnjakovic). Triggers "精读吧" / "发 wikijs" / "入库" / "A" / Id/DOI/PMID/PDF signals into 4-step精简 or 8-step完整 flows. PDF全文必传 + PyMuPDF xref去重 + 9项强制 + SeaFile hostname `fb.biokingdom.top` + NocoDB v1 JSON + 3张真图 + `journal-year-topic` 报告路径.
 - [Bosnjakovic 2025 PAH 3D 球体代谢组学: 跟 CelVivo ClinoStar dynamic culture 关系 (Bosnjakovic 2025 bioRxiv)](literature-cel-bosnjakovic-2025-pah-deepread.md) - Deep-read synthesis of Bosnjakovic A et al. 2025 bioRxiv preprint (DOI 10.1101/2025.07.10.663939v1, 2025-07-10) — 21-day mature HepG2 3D spheroids with graded non-cytotoxic BaP + BBF (PAH代表物) exposure for metabolomics biomarker discovery. Robin's connection: 3D spheroid protocol maps directly onto CelVivo ClinoStar dynamic culture; supports PAH exposure metabolomics positioning for hepatotoxicity / NAFLD modeling applications. 精读 2026-07-27.
@@ -14,7 +14,7 @@
 - [Raji 2026 (hMOs + 3Brain HD-MEA) — 7-27 增补版 (跟 7-01 矩阵集成)](literature-raji-2026-deepread.md) - Deep-read synthesis of Raji H, Bertoli F, Perez MJ, Lam A, Volpicelli-Daley LA, Deleidi M. 2026 Molecular Psychiatry (Nature 子刊, s41380-026-03667-4, DOI 10.1038/s41380-026-03667-4, IF 11) — human midbrain organoids (hMOs) with WNT modulation, dopaminergic neuron differentiation, bioreactor culture, and 3Brain HD-MEA electrophysiology for Parkinson's disease modeling. 7-01 实战范本 (page 1622) + 7-27 增补版 integrated with 3-paper 3Brain MEA matrix (Raji / Pali / Wei) and 4 product-line complementarity chain (CelVivo ClinoStar + Cellink BIO X + 3Brain HD-MEA + FemtoBiomed CellShot).
 - [Sharma 2026 — vascularized retinal organoid RGC survival and maturation (Cell Stem Cell)](literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md) - Deep-read synthesis of Sharma K et al. (2026) Cell Stem Cell — transiently vascularized human retinal organoids with RGC 18.2% vs ctrl-RO 1.21% at week 18, W31 ON/OFF/ON-OFF light responses, C3 endothelial monolayer integration strategy.
 - [3D 打印缓释 HCTZ 片: 跟 Cellink BIO X 挤出打印 (Tasevska 2025 EJPS)](literature-tasevska-2025-deepread.md) - Deep-read synthesis of Tasevska T et al. 2025 European Journal of Pharmaceutical Sciences 206:106998 (DOI 10.1016/j.ejps.2024.106998, 精读 2026-07-27) — first systematic SSE semi-solid extrusion vs DLP digital-light-processing comparison for sustained-release HCTZ (hydrochlorothiazide) tablets, with focus on SSE matching Cellink BIO X extrusion principle. Supports Robin's 3D-printed personalized-dose / sustained-release positioning and SSE extruder cross-sell narrative for Cellink BIO X accounts.
-- [Literature Deep-Reads — cross-agent deep-read index](literature.md) - Cross-agent index of Robin's literature deep-reads across the 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed) and adjacent application domains. Backed by the Obsidian vault 04-Literature/Deep-Reads/ and the flywheel-sync pipeline; synthesis pages are linked per paper.
+- [Literature Deep-Reads — cross-agent deep-read index](literature.md) - Cross-agent index of Robin's literature deep-reads across the 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed) and adjacent application domains (organoid IRB / ethics, vascularized organoids, microfluidic / organ-on-chip). Backed by the Obsidian vault 04-Literature/Deep-Reads/ and the flywheel-sync pipeline; synthesis pages are linked per paper.
 - [NocoDB 文献库索引 — 跨 agent 数据层](nocodb.md)
 - [OpenWiki Upgrade Drift (auto-generated)](openwiki-version-drift.md)
 - [OpenWiki 速查手册 (Robin 一次聊清, 直接拿来用)](OpenWiki%E9%80%9F%E6%9F%A5%E6%89%8B%E5%86%8C.md) - Compact OpenWiki cheat-sheet that condenses the 2026-07-27 6-conversation walkthrough into a single ready-to-share document. Designed for one-shot delivery to any agent / colleague / customer / manager who asks 'what is OpenWiki?' — covers the core concept, structure, sync model, and 4 active connectors in one page.
diff --git a/sources/literature.md b/sources/literature.md
index b6850f8..33d53a5 100644
--- a/sources/literature.md
+++ b/sources/literature.md
@@ -1,7 +1,7 @@
 ---
 type: "Reference"
 title: "Literature Deep-Reads — cross-agent deep-read index"
-description: "Cross-agent index of Robin's literature deep-reads across the 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed) and adjacent application domains. Backed by the Obsidian vault 04-Literature/Deep-Reads/ and the flywheel-sync pipeline; synthesis pages are linked per paper."
+description: "Cross-agent index of Robin's literature deep-reads across the 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed) and adjacent application domains (organoid IRB / ethics, vascularized organoids, microfluidic / organ-on-chip). Backed by the Obsidian vault 04-Literature/Deep-Reads/ and the flywheel-sync pipeline; synthesis pages are linked per paper."
 tags: [literature, deep-read, flywheel, celvivo, 3brain, cellink, femtobiomed]
 ---
 
@@ -13,6 +13,13 @@ tags: [literature, deep-read, flywheel, celvivo, 3brain, cellink, femtobiomed]
 
 ## Last 30 days of deep reads (mtime descending)
 
+### 2026-08-16 (Quintard 2024 + Guo 2026 — 2 papers on the same day)
+
+| DOI | Vendor | Application | Title (short) | Vault path |
+| --- | --- | --- | --- | --- |
+| `10.1038/s41467-024-45710-4` | CelVivo (ClinoStar rating 3 upstream) + Mimetas OrganoPlate (rating 4 direct) + Emulate Organ-Chip (rating 3) | Microfluidic platform for vascularized organoids | Quintard C et al. (2024) A microfluidic platform integrating functional vascularized organoids-on-chip (Nat Commun; 10 通道并行微流控芯片 + U 型捕获位 + hiPSC-BVO 30 天功能性灌注培养 + 跨类器官验证 [间充质球体 / BVO / 胰岛球体 / 肺类器官]; 血管层级化 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管, 壁剪切 27-2000 s⁻¹ 完美匹配人体毛细血管生理范围 50-1900 s⁻¹) — Wiki.js IDs 1719/1720/1722, NocoDB Id 3297; 4-commit LDR cycle 2026-08-16 (`0fc8db24` → `290e9635` → `24c713de` → `4073abf4`); last commit deleted the 3Brain reference per the SOP "硬门槛合规修正" cleanup rule | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` |
+| `10.3389/fcell.2026.1721946` | CelVivo (ClinoStar rating 4 clinical-translation IRB) + Mimetas OrganoPlate (rating 4 co-culture ethics) + Emulate Organ-Chip (rating 3) | Organoid research IRB / ethics systematic review | Guo Z & Zhang N (2026) Ethical review key considerations for organoid applications in biomedical research—a systematic review (Front Cell Dev Biol; 嘉兴市第一医院 + 嘉兴大学医学院视角; 类器官研究 IRB / 伦理审查 7 大强制要点系统综述 [样本来源/知情同意/数据隐私/共培养主体性/3R 动物福利/跨境监管/长期保存与终止使用] + 5 国对照 [中国《人类遗传资源管理条例》+《涉及人的生命科学和医学研究伦理审查办法》2023 / 美国 HIPAA + Common Rule + NIH GDS / 欧盟 GDPR + Clinical Trials Regulation 536/2014 / 日本 / 韩国]) — Wiki.js ID 1724, NocoDB Id 3298; 3-commit LDR cycle 2026-08-16 (`2e6f5989` → `00f824f2` → `a4fa5a32`); Robin translated the paper into a customer-facing IRB application checklist template at `templates/类器官IRB申请清单.md` v1.0 (180 lines; 7 mandatory points + 5 customer Q&A + China vs International flow + 10 attachments + 7 citations) | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` |
+
 ### 2026-08-09
 
 | DOI | Vendor | Application | Title (short) | Vault path |
diff --git a/sources/nocodb.md b/sources/nocodb.md
index 0bbb119..16559bb 100644
--- a/sources/nocodb.md
+++ b/sources/nocodb.md
@@ -1,3 +1,9 @@
+---
+type: "Reference"
+title: "NocoDB 文献库索引 — 跨 agent 数据层"
+openwiki_generated: true
+---
+
 # NocoDB 文献库索引 — 跨 agent 数据层
 
 > 数据源: NocoDB 13 个文献库 + 2 个公司库 (实时,每次 OpenWiki cron 跑时更新)
diff --git a/sources/ragflow.md b/sources/ragflow.md
index f37a815..aa5d655 100644
--- a/sources/ragflow.md
+++ b/sources/ragflow.md
@@ -1,3 +1,9 @@
+---
+type: "Reference"
+title: "RAGFlow 全文检索索引 (Robin KB system)"
+openwiki_generated: true
+---
+
 # RAGFlow 全文检索索引 (Robin KB system)
 
 > 数据源: RAGFlow (http://10.10.10.254:9980/) 14 个 KB 全文检索结果
diff --git a/sources/seafile.md b/sources/seafile.md
index 1d3e1c4..fce067b 100644
--- a/sources/seafile.md
+++ b/sources/seafile.md
@@ -1,3 +1,9 @@
+---
+type: "Reference"
+title: "SeaFile 大文件存储索引"
+openwiki_generated: true
+---
+
 # SeaFile 大文件存储索引
 
 > 数据源: SeaFile (http://10.10.10.254:9898/) 共 N 个资料库
diff --git a/sources/web-search.md b/sources/web-search.md
index feab622..e7e5098 100644
--- a/sources/web-search.md
+++ b/sources/web-search.md
@@ -2,12 +2,20 @@
 type: "Reference"
 title: "Web Search Evidence"
 description: "Compact, source-backed evidence and ingestion coverage for the web-search-1 Tavily lane tracking CelVivo, 3Brain, Cellink, and related organoid news."
-tags: [source, web-search, tavily, celvivo, 3brain, cellink, organoids, 2026-08-12, 2026-08-15, 2026-08-16]
+tags: [source, web-search, tavily, celvivo, 3brain, cellink, organoids, 2026-08-12, 2026-08-15, 2026-08-16, 2026-08-17]
 ---
 
 # Web Search Evidence
 
-> Connector: `web-search-1` (Tavily). This page records compact, relevant evidence from Tavily pulls; search results are discovery leads, not vendor-confirmed announcements. Latest successful pull: 2026-08-03 18:08 UTC. The 2026-08-08, 2026-08-10, 2026-08-12, and 2026-08-15 update attempts were skipped because the connector is disabled and `TAVILY_API_KEY` is not present; no new 24-hour evidence was available on any of these four runs.
+> Connector: `web-search-1` (Tavily). This page records compact, relevant evidence from Tavily pulls; search results are discovery leads, not vendor-confirmed announcements. Latest successful pull: 2026-08-03 18:08 UTC. The 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, and 2026-08-17 update attempts were skipped because the connector is disabled and `TAVILY_API_KEY` is not present; no new 24-hour evidence was available on any of these five runs.
+
+## 2026-08-17 attempted update — skipped
+
+- **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
+- **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
+- **Coverage:** no raw data files were written for this attempted 24-hour window. The nightly searxng-fallback slot (`~/.openwiki/connectors/web-search/raw/2026-08-16T18-35-03-searxng-fallback/`) is also empty — no web-search evidence of any kind landed in the 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
+- **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
+- **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, 2026-08-12, and 2026-08-15 runs hit the same blocker; this is the **fifth consecutive skip on the same code path**.
 
 ## 2026-08-15 attempted update — skipped
 
@@ -15,7 +23,7 @@ tags: [source, web-search, tavily, celvivo, 3brain, cellink, organoids, 2026-08-
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
-- **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, and 2026-08-12 runs hit the same blocker; this is the fourth consecutive skip on the same code path.
+- **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, and 2026-08-12 runs hit the same blocker; the 2026-08-17 run hit the same blocker too. This was the fourth consecutive skip on the same code path at the time of the 2026-08-15 attempt (and the fifth skip including the 2026-08-17 follow-up).
 
 ## 2026-08-12 attempted update — skipped
 
diff --git a/sources/wikijs.md b/sources/wikijs.md
index 2e2f31f..813538c 100644
--- a/sources/wikijs.md
+++ b/sources/wikijs.md
@@ -1,3 +1,9 @@
+---
+type: "Reference"
+title: "Wiki.js 索引 — 跨 agent 文档发布层"
+openwiki_generated: true
+---
+
 # Wiki.js 索引 — 跨 agent 文档发布层
 
 > 数据源: Wiki.js (http://10.10.10.254:3000/graphql) Biokingdom 实例
diff --git a/themes/01-organoid-equipment.md b/themes/01-organoid-equipment.md
index 1ebab5a..6ce2e53 100644
--- a/themes/01-organoid-equipment.md
+++ b/themes/01-organoid-equipment.md
@@ -61,6 +61,7 @@ The state diagram shows the canonical CelVivo → 3Brain workflow: 3D suspension
 - **Bosnjakovic 2025 bioRxiv (PAH HepG2 3D spheroid, ClinoStar dynamic culture)** — 21-day maturation + 24h/96h BaP/BBF exposure; **4 metabolic markers (phenylalanine, TCA intermediates, GSH depletion, sphingolipid dysregulation) only appear in 3D, completely invisible in 2D**. Sales ammunition: "your 2D model is missing 100% of environmental toxicology early signals". Synthesis at [`/sources/literature-cel-bosnjakovic-2025-pah-deepread.md`](/sources/literature-cel-bosnjakovic-2025-pah-deepread.md).
 - **Miao 2025 Cell v2 (co-differentiation mesoderm + endoderm, vascularized lung/gut organoids, ClinoStar rotating culture)** — single 3D EB co-induction strategy yields **vHLPO with 7% ECs vs traditional HLPO 0%**, organ-specific endothelium + mesenchyme scRNA-seq validation, in-vivo functional integration with host circulation, FOXF1 mutation ACDMPV dual-pathology disease modeling. Product relevance: CelVivo ClinoStar rating 5 (co-differentiation depends on 3D EB self-organization in low-shear rotating culture — ClinoStar is the canonical hardware), HD-MEA rating 4, 3D bioprinting rating 3, patient-derived organoid drug screening rating 5. Synthesis at [`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`](/sources/literature-miao-2025-cell-vascularization-v2-deepread.md).
 - **Liu 2026 Nat Biomed Eng (shape-conformal porous framework for neural organoid e-phys, Rogers Lab)** — CelVivo ClinoStar rating 4 (organoid culture downstream of the shape-conformal framework; long-term maturation + functional readout is the canonical ClinoStar → HD-MEA workflow). Synthesis at [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md). See 3Brain evidence for the HD-MEA read side.
+- **Quintard 2024 Nat Commun (microfluidic platform integrating functional vascularized organoids-on-chip, 2026-08-16)** — CelVivo ClinoStar rating 3 (upstream workflow: BVO differentiation day 0-15 needs rotating-wall suspension culture; ClinoStar is the canonical hardware for this stage; the paper's day 15 → chip-on-board handoff is the canonical CelVivo → organ-on-chip workflow). Mimetas OrganoPlate rating 4 (direct Phaseguide-based vascularized / kidney / intestine organ-on-chip competitor — Robin's portfolio does not currently cover Mimetas but the platform represents a candidate cross-sell if Robin's customers ask "where do I run my CelVivo-matured organoids in a vascularized microenvironment?"). Emulate Organ-Chip rating 3 (Colon-Intestine-Liver platform companion). 10 通道并行微流控芯片 + hiPSC-BVO + 间充质球体 + 胰岛球体 + 肺类器官 跨类器官验证; 血管层级化 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管; 壁剪切 27-2000 s⁻¹ 完美匹配人体毛细血管生理范围 50-1900 s⁻¹. 4-commit LDR cycle 2026-08-16 (commits `0fc8db24` → `290e9635` → `24c713de` → `4073abf4` — last commit deleted the 3Brain reference per the SOP "硬门槛合规修正" cleanup rule because Quintard is organ-on-chip territory rather than 3Brain territory). Wiki IDs 1719/1720/1722, NocoDB Id 3297, DOI 10.1038/s41467-024-45710-4. Sales ammunition: "你的类器官前段培养到 day 15, 后段血管化怎么接? 我们的 CelVivo ClinoStar 提供 day 0-15 金标准旋转培养, 后接 Quintard 2024 微流控芯片做 30 天功能性血管化灌注". Customer entry: 药企临床前 (vascularized drug screening) + 微流控 organ-on-chip 平台集成商 (Mimetas / Emulate channel partners) + academic PI (vascular development / diabetes). Vault path: `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` (189 lines + 6 真图).
 - **Liang 2026 Sci Rep (mouse liver organoid 3-轨道 + fibrosis modeling, 2026-08-12)** — CelVivo ClinoStar rating 4 (P1-P10 长程扩增对应旋转培养 30+ 天无剪切; single DAPT only sustains P5, DAPT+Dex 协同才实现 P10 稳定成熟), CelVivo ClinoReactor rating 4 (单组织 3 轨道 [Hep/Cho/HSC] 分通道灌流; TGFβ 时间程序精确切换实现纤维化激活模型), CelVivo PhaseHolographic 成像 rating 3 (3D 球体直径/CV 实时 QC), 3Brain HD-MEA rating 3 (肝-神经互作延伸场景). 3 轨道 from 单份小鼠肝组织 (密度梯度离心 + 差速贴壁) → DAPT+Dex P1-P10 长程稳定成熟 (ALB / PAS / LDL / CYP 跨代保持) → TGFβ 5-7 天激活 qHSC → aHSC (Acta2/Col1a1 上调) → aHSC 共培养诱导 Hep-Orgs EMT (Snail/Twist/Vimentin ↑; ALB/CK8 ↓; Lgr5/EpCAM ↓; Ki67 ↓) = 体外肝纤维化模型. Wiki.js Id=1716, NocoDB Id=770, PMID 41857098. Page 946 9 项 SOP 重写版 + page 934 修齐 标杆 (4-commit LDR cycle 2026-08-12). **First deep-read whose `related:` field already names `[[MOC-类器官与3D培养]]`** on the day of publication — confirms MOC pattern in active use on real deep-reads. Vault path: `04-Literature/Deep-Reads/Liver/2026-08-12_Liang_2026_SciRep_liver_organoid_fibrosis_platform.md` (170 lines). Sales ammunition: "你的肝类器官只能短期培养? DAPT+Dex P1-P10 稳定成熟 + 单组织 3 轨道 + 14 天纤维化模型 — ClinoStar + ClinoReactor 一站搞定". Customer entry: 药企临床前 (抗纤维化药筛 14+ 天 3D 多细胞模型) + 临床肝活检中心 (1-2 mg 组织 → 3 周药敏 → ClinoReactor 6 通道一次测 6 药). Tracks in `/commitments.md` as `liang-2026-celvivo-clinostar-positioning`.
 - **Sales ammunition kit (CelVivo pricing + 8 Protocols + 5 app notes + 5 brand/whitepapers)** — Demo kit `10005-6` lists at €300 (Global Distributor Price, with special discount). 8 ClinoReactor Protocols cover prepare / media change / gardening / plate config / rotation-speed / alginate embed / VitroGel embed. 5 application notes cover HepG2/C3A liver, FTC-133 thyroid, NCI-H69V SCLC, TNBC, ClinoStar vs Orbital Shaker. Synthesis at [`/sources/sales-ammunition.md`](/sources/sales-ammunition.md).
 - **260528_CS vs OS app note (2026-07-17 deep read)** — ClinoStar vs Orbital Shaker shear-stress comparison for long-term 3D construct performance; ClinoStar has lower shear + long-term growth + better consistency. This is the **vs-competitor killer document** for "why not use an orbital shaker" customer questions.
@@ -93,6 +94,7 @@ The state diagram shows the canonical CelVivo → 3Brain workflow: 3D suspension
 
 - **China CDE cell & gene therapy classification rules (2026-07-24)** — affects CelVivo-class deals in the Chinese pharma R&D / CDMO customer base. Tracks in [`/commitments.md`](/commitments.md) `china-cde-cell-gene-therapy-rules-2026`.
 - **China Order No. 818 (effective 2026-05-01)** — accelerated clinical-translation pathway for cell therapy and 3D bioprinting at qualified hospitals. Tracks as `china-order-no-818-clinical-translation`.
+- **Guo 2026 Front Cell Dev Biol organoid IRB / ethics systematic review (2026-08-16)** — CelVivo ClinoStar ⭐⭐⭐⭐ clinical-translation IRB compliance; **Robin 推广 ClinoStar 给三甲医院时, 可附带 Guo 2026 框架作为增值**. The paper structures the IRB review framework as 7 mandatory points (sample provenance + donor informed consent + data privacy & de-identification + co-culture agency + animal welfare 3R + cross-border regulation + long-term storage & termination) + a 5-jurisdiction cross-border table (China《人类遗传资源管理条例》+《涉及人的生命科学和医学研究伦理审查办法》2023 vs US HIPAA + Common Rule + NIH GDS vs EU GDPR + Clinical Trials Regulation 536/2014 vs Japan / Korea). 3-commit LDR cycle 2026-08-16 (`2e6f5989` → `00f824f2` → `a4fa5a32`). Wiki.js ID 1724, NocoDB Id 3298, DOI 10.3389/fcell.2026.1721946. **Robin translated the paper into a customer-facing IRB application checklist template** at `templates/类器官IRB申请清单.md` v1.0 (180 lines; 7 mandatory points checklist + 5 customer Q&A + China vs International flow table + 10 attachments + 7 citations). Tracks in `/commitments.md` as `guo-2026-organoid-irb-checklist-rollout` (Owner: me; fold IRB application checklist into CelVivo industrial-customers program + Robin customer-training core material; commit the template and add a synthesis page at `/sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md`). Vault path: `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` (170 lines + 3 真图).
 - **China CGT 2026-07 developments** — Merck–Bio-Techne $11.3B acquisition, CARsgen satri-cel solid-tumor CAR-T approval (positive); gene-editing trial death + regulatory backlash (negative). Tracks as `china-cgt-2026-july-developments`.
 
 ## Cross-cutting relationship
@@ -112,8 +114,11 @@ The state diagram shows the canonical CelVivo → 3Brain workflow: 3D suspension
 | What is Liu 2026's shape-conformal neural organoid e-phys story? | [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md) |
 | What is Sharma 2026's vascularized retinal organoid RGC story? | [`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`](/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md) |
 | What is Liang 2026's liver organoid fibrosis platform story? | `04-Literature/Deep-Reads/Liver/2026-08-12_Liang_2026_SciRep_liver_organoid_fibrosis_platform.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
+| What is Quintard 2024's vascularized organoid chip story? | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
+| What is Guo 2026's organoid IRB / ethics story? | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
+| What is the IRB application checklist for organoid research? | `templates/类器官IRB申请清单.md` v1.0 (vault path; untracked) |
 | What distributors am I actually working with? | [`/sources/agents.md`](/sources/agents.md) |
 | Which Chinese dealers carry our brand? | [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) |
-| What regulatory shifts affect our Chinese pharma deals? | [`/commitments.md`](/commitments.md) China CDE / Order No. 818 / China CGT items |
+| What regulatory shifts affect our Chinese pharma deals? | [`/commitments.md`](/commitments.md) China CDE / Order No. 818 / Guo 2026 IRB / China CGT items |
 | What conferences is 3Brain at this season? | [`/commitments.md`](/commitments.md) `3brain-coreplate-2026-conference-positioning` |
 | What's the CelVivo → 3Brain joint workflow? | [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) (this page) Workflow chain section |
\ No newline at end of file
diff --git a/themes/05-robin-research.md b/themes/05-robin-research.md
index 86785ec..b77ac02 100644
--- a/themes/05-robin-research.md
+++ b/themes/05-robin-research.md
@@ -2,8 +2,8 @@
 type: "Reference"
 title: "Theme 5 · Robin's personal research (vendor deep reads + sales ammunition + CRM)"
 description: "Synthesis page for Robin's personal research portfolio — Obsidian vault + literature deep-read pipeline + sales ammunition + China distributor map + active CRM profiles + work-rhythm snapshots. Output routes into vendor themes 01 (organoid-equipment) and 02 (bioprinting)."
-tags: [theme, research, vault, deep-read, sales, crm, life-sciences, 2026-08-15, 2026-08-13]
-timestamp: 2026-08-15T18:07:49Z
+tags: [theme, research, vault, deep-read, sales, crm, life-sciences, 2026-08-17, 2026-08-15, 2026-08-13]
+timestamp: 2026-08-17T18:09:32Z
 ---
 
 # Theme 5 · Robin's personal research (vendor deep reads + sales ammunition + CRM)
@@ -23,7 +23,7 @@ This is the synthesis page for **Robin 个人研究项目** — the durable body
 
 ```mermaid
 erDiagram
-    VAULT["Obsidian vault (297f106d)"] ||--o{ DEEPREADS["Deep-read notes ~1,205"]
+    VAULT["Obsidian vault (a4fa5a32)"] ||--o{ DEEPREADS["Deep-read notes ~1,207"]
     VAULT ||--o{ TRAIN["Sales training (CelVivo赋能培训 v1-v9)"]
     VAULT ||--o{ SALES["Active sales pipeline (惠百生物 PO + 中间商)"]
     VAULT ||--o{ CRM["Distributor profiles (董慧群 + 待补)"]
@@ -32,6 +32,7 @@ erDiagram
     VAULT ||--o{ MEMORY["Daily + weekly reports (memory/ 147 .md)"]
     VAULT ||--o{ ITX["ITX 24h host build (untracked)"]
     VAULT ||--o{ MOC["MOCs (类器官与3D培养 first, +planned)"]
+    VAULT ||--o{ TEMPLATES["Templates (类器官IRB申请清单 v1.0, untracked)"]
 
     DEEPREADS }o--|| VENDOR["Vendor mapping"]
     VENDOR ||--|{ CelVivo["CelVivo (ClinoStar / ClinoReactor)"]
@@ -50,19 +51,19 @@ The diagram shows Robin's research substrate: a single Obsidian vault with 8 buc
 
 ## Knowledge substrate: Obsidian vault
 
-Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08-15T18:07:49Z):
+Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08-17T18:09:32Z):
 
 | Field | Value |
 | --- | --- |
 | Repo path | `/home/ldw/workspace` |
 | Branch | `main` |
-| HEAD | `297f106d2b137af3480261052ff080cbc48d5b48` (**unchanged** across both 2026-08-13 and 2026-08-15 fetches — 0 new vault commits in the 2026-08-13T18:08Z → 2026-08-15T18:07Z 48-hour window; the 2026-08-12 Liang 2026 4-commit LDR cycle remains the most recent vault activity) |
-| Ahead of origin/main | 13 commits new since 2026-08-03 fetch (Fernandez Vallone 2026 + Microbioreactor 2026 + Liu 2026 v2-v11 + 4 经销商 hook 升级 + Wang 2024 Theranostics + **Phase A metadata batch + 2 sample runs** + **Liang 2026 liver organoid fibrosis platform 4-commit LDR cycle**); plus **23 untracked files** in working tree (unchanged from the 2026-08-13 fetch — 0 new untracked files appeared in the 2026-08-13T18:08Z → 2026-08-15T18:07Z 24-hour window) |
+| HEAD | `a4fa5a323d6dcabeb9eccad49e636ee6ba5f87a6` (**bumped** from `297f106d` at the 2026-08-17 fetch — **7 new vault commits** in the 2026-08-15T18:07Z → 2026-08-17T18:09Z 48-hour window: the 2026-08-16 Quintard 2024 Nat Commun microfluidic vascularized organoid chip 4-commit LDR cycle + the 2026-08-16 Guo 2026 Front Cell Dev Biol organoid ethics systematic review 3-commit LDR cycle — first time two new paper deep-reads landed on `main` in the same 48-hour window since the 2026-07-28 / 2026-07-29 Parate / Lee / Hodge cluster) |
+| Ahead of origin/main | 20 commits new since 2026-08-03 fetch (was 13 at the 2026-08-15 fetch; the +7 delta is the Quintard 2024 + Guo 2026 clusters) |
 | Auth | local path only — no remote, no credentials |
-| Working-tree state | dirty (1 nested-submodule + 1 untracked dir + 23 untracked files including 8 new `02-Clients/Agents/区域-2026-0807.md` + the still-untracked `Review/zhou2023_computer_vision_microfluidics.md` first-entry-in-Review/-subfolder file) |
-| Raw manifest | `~/.openwiki/connectors/git-repo/raw/2026-08-15T18-07-49-711Z/manifest.json` |
-| **Latest cluster (2026-08-12, unchanged across both 2026-08-13 + 2026-08-15 fetches)** | **Liang 2026 Sci Rep liver organoid fibrosis platform 4-commit LDR cycle** (`e542c977` adds file 186 lines → `8699a154` page 946 9 项 SOP 重写版 105+/122- → `aacba7aa` frontmatter title 改中文 1 line → `297f106d` page 934 修齐 5+/4-) — **net-new external evidence** (DOI 10.1038/s41598-026-42990-2, PMID 41857098, mouse liver 3-轨道 Hep-Orgs + Cho-Orgs + HSC + DAPT+Dex P1-P10 长程成熟 + TGFβ 激活体外纤维化模型) |
-| **Latest uncommitted file (2026-08-13, still-uncommitted at 2026-08-15)** | `04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md` — **first entry in the new `Review/` subfolder**; review-type papers stream separately from original-research stream; carry-forward status unchanged across the 2026-08-13 + 2026-08-15 fetches |
+| Working-tree state | dirty (23 untracked files + 2 new untracked directories — `celvivo_commercial/1331651_20260630_131201.pdf` + `templates/类器官IRB申请清单.md` — both untracked; the `Review/zhou2023_computer_vision_microfluidics.md` first-entry-in-Review/-subfolder is still-uncommitted, carrying forward from the 2026-08-13 fetch) |
+| Raw manifest | `~/.openwiki/connectors/git-repo/raw/2026-08-17T18-09-32-895Z/manifest.json` |
+| **Latest cluster (2026-08-16, replacing the 2026-08-12 Liang 2026 cluster)** | **Quintard 2024 Nat Commun + Guo 2026 Front Cell Dev Biol 7-commit LDR cluster** (`0fc8db24` Quintard adds file 189 lines → `290e9635` -v2 → `24c713de` -v3 → `4073abf4` -v4 → `2e6f5989` Guo adds file 170 lines → `00f824f2` -v2 → `a4fa5a32` -v3) — **net-new external evidence** (DOI 10.1038/s41598-026-42990-2, PMID 41857098, mouse liver 3-轨道 Hep-Orgs + Cho-Orgs + HSC + DAPT+Dex P1-P10 长程成熟 + TGFβ 激活体外纤维化模型) |
+| **Latest uncommitted artifact (2026-08-13 → 2026-08-17, multi-file)** | `04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md` (carry-forward untracked from 2026-08-13) + **2 new untracked directories added at the 2026-08-17 fetch**: `celvivo_commercial/1331651_20260630_131201.pdf` (6-30 quote PDF migrated into new folder) + `templates/类器官IRB申请清单.md` (180-line IRB application checklist derived from Guo 2026; Robin's first customer-facing template produced from a single deep-read — see the new Templates subtree below) |
 
 ### Vault navigation index (top-level folders)
 
@@ -91,7 +92,7 @@ Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08
 
 | Subfolder | .md count | Vendor / scope |
 | --- | ---: | --- |
-| `Organoid/` | 659 | broad organoid literature |
+| `Organoid/` | 661 (+2 from 2026-08-16 — Quintard 2024 Nat Commun microfluidic vascularized organoid chip + Guo 2026 Front Cell Dev Biol organoid ethics systematic review) | broad organoid literature |
 | `Celvivo/` | 142 | CelVivo vendor + CelVivo-adjacent papers |
 | `3Brain/` | 136 | 3Brain vendor + 3Brain-adjacent papers |
 | `Cellink/` | 129 | Cellink vendor + Cellink-adjacent papers |
@@ -110,8 +111,10 @@ Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08
 | `Microbioreactor/` | 1 | Rosero 2026 Front Bioeng Biotechnol (added 2026-08-07) |
 | `Cells/` | 1 | Fernandez Vallone 2026 Cells THSDC (added 2026-08-08) |
 | `Review/` | 1 | Zhou 2023 computer vision + microfluidics (added 2026-08-13, **untracked**) |
+| `Templates/` | 1 | `类器官IRB申请清单.md` v1.0 (2026-08-16, derived from Guo 2026 ethics deep-read, **untracked**; first customer-facing template produced from a single deep-read) |
+| `CelVivo-commercial/` | 1 | `1331651_20260630_131201.pdf` (2026-06-30 quote PDF migrated into new folder 2026-08-17, **untracked**) |
 
-Total ≈ 1,204 deep-read notes on `main` + **1 untracked entry in the new `Review/` subfolder** (`zhou2023_computer_vision_microfluidics.md`, 2026-08-13 — first review-type subfolder; future-commit candidate). The 4 vendor subfolders (Celvivo / 3Brain / Cellink / Organoid) cover the canonical product KB per the wiki goal focus areas.
+Total ≈ 1,206 deep-read notes on `main` + **1 untracked entry in the new `Review/` subfolder** (`zhou2023_computer_vision_microfluidics.md`, 2026-08-13 — first review-type subfolder; future-commit candidate) + **2 new untracked directories** (`templates/类器官IRB申请清单.md` + `celvivo_commercial/1331651_20260630_131201.pdf`, 2026-08-17). The 4 vendor subfolders (Celvivo / 3Brain / Cellink / Organoid) cover the canonical product KB per the wiki goal focus areas. The new `templates/` folder signals Robin may be formalizing customer-facing deliverables (checklists / templates / sales scripts) as a separate vault subtree — the IRB application checklist is the first such artifact.
 
 ## Literature deep-read (LDR) pipeline
 
@@ -180,6 +183,8 @@ From [`/sources/ldr-report-template.md`](/sources/ldr-report-template.md) (Robin
 | Sharma 2026 Cell Stem Cell (2026-08-08 flywheel-sync) | 3Brain + CelVivo adjacent | `/home/ldw/workspace/retinal_organoid_deep_read_2026-08-07.md` | [`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`](/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md) |
 | Miao 2025 Cell v2 (2026-08-08 flywheel-sync) | CelVivo (ClinoStar rating 5) | `/home/ldw/workspace/Miao2025_Cell_v2.md` | [`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`](/sources/literature-miao-2025-cell-vascularization-v2-deepread.md) |
 | Liu 2026 Nat Biomed Eng (2026-08-08 flywheel-sync) | 3Brain (HD-MEA rating 5) + Cellink (microlattice rating 5) | `/home/ldw/workspace/Liu2026_NBME_shape_conformal_organoid.md` | [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md) |
+| Quintard 2024 Nat Commun (2026-08-16 vault LDR cluster) | CelVivo (ClinoStar rating 3 upstream) + Mimetas OrganoPlate (rating 4 direct) + Emulate Organ-Chip (rating 3) | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` | (not yet synthesized to `/sources/`) |
+| Guo 2026 Front Cell Dev Biol (2026-08-16 vault LDR cluster) | CelVivo (ClinoStar rating 4 clinical-translation IRB) + Mimetas OrganoPlate (rating 4 co-culture ethics) + Emulate Organ-Chip (rating 3) | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` | (not yet synthesized to `/sources/`; derived customer-facing template at `templates/类器官IRB申请清单.md` v1.0) |
 
 ## Recent 30-day research output (mtime 2026-06-16 → 2026-08-12)
 
@@ -187,6 +192,7 @@ From [`/sources/literature.md`](/sources/literature.md) last sync, broken out by
 
 | Date | DOI / slug | Vendor | Topic |
 | --- | --- | --- | --- |
+| 2026-08-16 | **Quintard 2024 Nat Commun + Guo 2026 Front Cell Dev Biol 7-commit LDR cluster** (commits `0fc8db24` + `290e9635` + `24c713de` + `4073abf4` Quintard + `2e6f5989` + `00f824f2` + `a4fa5a32` Guo) | **CelVivo adjacent + Mimetas OrganoPlate ⭐⭐⭐⭐ + Emulate Organ-Chip ⭐⭐⭐** (Quintard) / **CelVivo ClinoStar ⭐⭐⭐⭐ + Mimetas OrganoPlate ⭐⭐⭐⭐ + Emulate Organ-Chip ⭐⭐⭐** (Guo) | Quintard C et al. (2024) A microfluidic platform integrating functional vascularized organoids-on-chip (Nat Commun DOI 10.1038/s41467-024-45710-4, Wiki ID 1719/1720/1722, NocoDB Id 3297; 10 通道并行微流控 + hiPSC-BVO 30 天功能性灌注培养 + 跨类器官验证 [间充质球体 / BVO / 胰岛球体 / 肺类器官]; 血管层级化 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管, 壁剪切 27-2000 s⁻¹, 完美匹配人体毛细血管生理范围 50-1900 s⁻¹) + Guo Z & Zhang N (2026) Ethical review key considerations for organoid applications in biomedical research—a systematic review (Front Cell Dev Biol DOI 10.3389/fcell.2026.1721946, Wiki ID 1724, NocoDB Id 3298; 嘉兴市第一医院 + 嘉兴大学医学院视角; 类器官研究 IRB / 伦理审查 7 大强制要点系统综述 [样本来源/知情同意/数据隐私/共培养主体性/3R 动物福利/跨境监管/长期保存与终止使用] + 中国《人类遗传资源管理条例》+ 国际 ISSCR/GDPR/HIPAA 多国对照表). **Robin translated Guo 2026 into a customer-facing IRB application checklist template** (`templates/类器官IRB申请清单.md` v1.0 180 lines) — first customer-facing template produced from a single deep-read. |
 | 2026-08-12 | **Liang 2026 liver organoid fibrosis platform 4-commit LDR cycle** (commits `e542c977` + `8699a154` + `aacba7aa` + `297f106d`) | **CelVivo (ClinoStar rating 5 + ClinoReactor rating 5)** | Liang Y et al. (2026) A robust mouse liver organoid platform enables sustained multicellular maturation and fibrosis modeling from a single tissue sample (Sci Rep DOI 10.1038/s41598-026-42990-2, PMID 41857098; Wiki.js Id 1716, NocoDB Id 770; 3 轨道 Hep-Orgs + Cho-Orgs + HSC 同步分离; DAPT+Dex P1-P10 长程稳定成熟 [ALB/PAS/LDL/CYP 跨代保持]; TGFβ 激活 qHSC → aHSC [Acta2/Col1a1 上调]; aHSC 共培养诱导 Hep-Orgs EMT [Snail/Twist/Vimentin↑; ALB/CK8↓; Lgr5/EpCAM↓; Ki67↓] = 体外肝纤维化模型) — page 946 9 项 SOP 重写版 + page 934 修齐 标杆; 7/7 Ollama qwen2.5vl 视觉审核通过; SeaFile 7/7 公网 200 验真. First paper whose `related:` field already names `[[MOC-类器官与3D培养]]` (the 2026-08-10 first MOC) on the day of publication. |
 | 2026-08-10 | **Phase A metadata batch + first MOC** (commits `d97b39ed` + `6b717aef` + `3b929c2f`) | (process discipline) | 6 deep-reads received the 6-field frontmatter (doi/journal/year/volume/pages/authors/pmid); first MOC `MOC-类器官与3D培养.md` (95 lines, 沙牛《AI 时代的 Obsidian 公开课》课时 1 pattern) created at `04-Literature/Deep-Reads/MOCs/`; 7 image alt descriptions added on `wang2024-org-on-chip.md`. No new external evidence. |
 | 2026-08-09 | `10.7150/thno.90492` (Wang 2024) | (4 类共性硬件 — Organoid-on-Chip 综述) | Wang H et al. (2024) Human organoids-on-chips for biomedical research and applications (Theranostics 14(2):788-818, PMID 38169573; 7 图覆盖 7 大主题板块) — Wiki.js ID 1700 (v2 - grp:3 ghost page 累加) |
@@ -214,16 +220,18 @@ From [`/sources/literature.md`](/sources/literature.md) last sync, broken out by
 
 By vendor (30-day mtime):
 
-| Vendor | Most recent | 2026-08-08 / 2026-08-10 / 2026-08-12 additions |
+| Vendor | Most recent | 2026-08-08 / 2026-08-10 / 2026-08-12 / 2026-08-16 additions |
 | --- | --- | --- |
-| CelVivo | 2026-08-12 (Liang 2026 — ClinoStar rating 5 + ClinoReactor rating 5) | +Liang 2026 (P1-P10 长程成熟 + 单组织 3 轨道分通道灌流 + TGFβ 时间程序精确切换 — liver organoid fibrosis platform), +Miao 2025 v2 (ClinoStar co-differentiation), +Sharma 2026 (ClinoStar rating 3 adjacent), +Liu 2026 (ClinoStar rating 4 adjacent) |
-| 3Brain | 2026-08-08 (Liu 2026 — HD-MEA rating 5) | +Liu 2026 (shape-conformal framework, next-gen HD-MEA), +Sharma 2026 (HD-MEA rating 4 adjacent), +Shin 2024 (Phase A frontmatter hygiene on existing note) |
-| Cellink | 2026-07-27 (Tasevska 2025) | +Liu 2026 (microlattice fabrication rating 5 adjacent) |
+| CelVivo | 2026-08-12 (Liang 2026 — ClinoStar rating 5 + ClinoReactor rating 5) | +Liang 2026 (P1-P10 长程成熟 + 单组织 3 轨道分通道灌流 + TGFβ 时间程序精确切换 — liver organoid fibrosis platform), +Miao 2025 v2 (ClinoStar co-differentiation), +Sharma 2026 (ClinoStar rating 3 adjacent), +Liu 2026 (ClinoStar rating 4 adjacent), +Quintard 2024 (CelVivo ClinoStar rating 3 — upstream workflow step: BVO day 0-15 needs rotating-wall suspension culture), +Guo 2026 (CelVivo ClinoStar rating 4 — clinical-translation IRB compliance for 三甲医院 客户) |
+| 3Brain | 2026-08-08 (Liu 2026 — HD-MEA rating 5) | +Liu 2026 (shape-conformal framework, next-gen HD-MEA), +Sharma 2026 (HD-MEA rating 4 adjacent), +Shin 2024 (Phase A frontmatter hygiene on existing note), **−3Brain reference removed from Quintard 2024 -v4 (per commit `4073abf4` — "精读 Quintard 2024 -v4 (转发语标题/落款加粗/删3Brain)" was the explicit SOP rule "硬门槛合规修正" cleanup; Quintard is vendor-adjacent CelVivo/Mimetas/Emulate rather than 3Brain territory)** |
+| Cellink | 2026-07-27 (Tasevska 2025) | +Liu 2026 (microlattice fabrication rating 5 adjacent), **+Quintard 2024 (microfluidic organ-on-chip adjacent, no direct Cellink rating — but the platform architecture is a candidate cross-sell with Cellink BIO X for vascularized scaffold fabrication)** |
 | Adjacent (no vendor) | 2026-08-08 (Sharma 2026 retinal vascularization) | +Sharma 2026 (retinal organoid application domain) |
 | (Process discipline) | 2026-08-10 (Phase A batch + first MOC) | +6 deep-reads received 6-field frontmatter; +first MOC `MOC-类器官与3D培养.md` created; +7 image alt descriptions on Wang 2024 — no new external evidence |
 | (Subfolder expansion, uncommitted) | 2026-08-13 (new `Review/` subfolder) | +1 untracked file `Review/zhou2023_computer_vision_microfluidics.md` (first review-type subfolder — review papers stream separately from original research) |
+| (Customer-facing template, uncommitted) | 2026-08-16 (new `templates/` subfolder + IRB application checklist v1.0) | +1 untracked file `templates/类器官IRB申请清单.md` 180 lines (Guo 2026 ethics deep-read → IRB checklist template; 7 mandatory points + 5 customer Q&A + China vs International flow + 10 attachments + 7 citations; Robin's first customer-facing template produced from a single deep-read; will route into CelVivo industrial-customers program once committed) |
+| (Commercial quote PDF, untracked) | 2026-08-17 (new `celvivo_commercial/` subfolder) | +1 untracked file `celvivo_commercial/1331651_20260630_131201.pdf` (6-30 quote PDF migrated into a new folder; companion to the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree) |
 
-The pipeline is **vendor-balanced** — CelVivo, 3Brain, Cellink each have a recent deep read, and the 2026-08-08 flywheel-sync adds **3 papers spanning all 3 primary vendors + the retinal organoid application domain** (Sharma), all 3 rated 4-5 on at least one vendor's product line. The 2026-08-10 cluster is **process discipline** (Phase A metadata batch + first MOC creation + Wang 2024 alt-description sample), not new external evidence — the 6 deep-reads already existed on `main`; the 3 commits only normalize their metadata and add a knowledge-graph index layer. The 2026-08-12 cluster adds **net-new external evidence**: Liang 2026 Sci Rep liver organoid fibrosis platform (4-commit LDR cycle on a single paper, CelVivo ClinoStar ⭐⭐⭐⭐ + ClinoReactor ⭐⭐⭐⭐); this is the **first paper on `main` whose `related:` field already names `[[MOC-类器官与3D培养]]` on the day of publication**, confirming the MOC pattern is in active use on real deep-reads (vs the prior 2026-08-10 "MOC `related:` lists future MOCs" framing which was only prospective). The **first entry in the new NocoDB table `Robin_Picked_Papers`** is Liu 2026 (created 2026-08-08 per Robin instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage). The **first MOC** `MOC-类器官与3D培养.md` is the start of a Map-of-Content layer Robin appears to be building (the MOC's own `related:` already names `[[MOC-3Brain-HD-MEA]]` as the next planned MOC). The 2026-08-13 cluster (no vault commits, 1 new untracked file) **adds a new `Review/` subfolder to the deep-read tree** — Robin appears to be expanding the folder taxonomy to separate review-type papers from original-research papers; whether this is a one-off subfolder or the start of a recurring folder pattern is a watchlist item for the next git-repo fetch.
+The pipeline is **vendor-balanced** — CelVivo, 3Brain, Cellink each have a recent deep read, and the 2026-08-08 flywheel-sync adds **3 papers spanning all 3 primary vendors + the retinal organoid application domain** (Sharma), all 3 rated 4-5 on at least one vendor's product line. The 2026-08-10 cluster is **process discipline** (Phase A metadata batch + first MOC creation + Wang 2024 alt-description sample), not new external evidence — the 6 deep-reads already existed on `main`; the 3 commits only normalize their metadata and add a knowledge-graph index layer. The 2026-08-12 cluster adds **net-new external evidence**: Liang 2026 Sci Rep liver organoid fibrosis platform (4-commit LDR cycle on a single paper, CelVivo ClinoStar ⭐⭐⭐⭐ + ClinoReactor ⭐⭐⭐⭐); this is the **first paper on `main` whose `related:` field already names `[[MOC-类器官与3D培养]]` on the day of publication**, confirming the MOC pattern is in active use on real deep-reads (vs the prior 2026-08-10 "MOC `related:` lists future MOCs" framing which was only prospective). The **first entry in the new NocoDB table `Robin_Picked_Papers`** is Liu 2026 (created 2026-08-08 per Robin instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage). The **first MOC** `MOC-类器官与3D培养.md` is the start of a Map-of-Content layer Robin appears to be building (the MOC's own `related:` already names `[[MOC-3Brain-HD-MEA]]` as the next planned MOC). The 2026-08-13 cluster (no vault commits, 1 new untracked file) **adds a new `Review/` subfolder to the deep-read tree** — Robin appears to be expanding the folder taxonomy to separate review-type papers from original-research papers; whether this is a one-off subfolder or the start of a recurring folder pattern is a watchlist item for the next git-repo fetch. **The 2026-08-16 cluster (Quintard 2024 + Guo 2026) is the largest single-window vault delta since the 2026-07-28 / 2026-07-29 cluster** — 7 new vault commits spanning 2 new paper deep-reads, 2 new untracked working-tree directories, and 1 customer-facing sales-ammunition template derived from a single deep-read. The Quintard 2024 microfluidic / organ-on-chip platform (CelVivo ClinoStar upstream + Mimetas OrganoPlate direct competitor + Emulate Organ-Chip) extends Robin's vendor mapping into the organ-on-chip product lane that his portfolio doesn't currently cover; the Guo 2026 organoid ethics systematic review (7 mandatory points + 5 jurisdiction comparison) introduces the IRB / ethics domain to Robin's deep-read set and spawned `templates/类器官IRB申请清单.md` (180 lines, Robin's first customer-facing template) as the canonical "Robin 培训客户 IRB 申请" core material. The new `templates/` + `celvivo_commercial/` directories appear alongside the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree — Robin may be formalizing customer-facing deliverables (checklists / templates / sales scripts) as a separate vault subtree. The `Review/zhou2023_computer_vision_microfluidics.md` carry-forward untracked file is still-uncommitted at this fetch (now 4 days past the 2026-08-13 first observation); the watchlist trigger is if it remains uncommitted at the next fetch.
 
 ## Sales ammunition pipeline
 
@@ -237,6 +245,8 @@ Robin maintains a working sales library that consumes LDR output and routes into
 
 Cross-link to the canonical synthesis: [`/sources/sales-ammunition.md`](/sources/sales-ammunition.md).
 
+**2026-08-16 addition — `templates/类器官IRB申请清单.md` v1.0** (180 lines, Robin 8-16 实战沉淀, **untracked**; derived from Guo 2026 Front Cell Dev Biol IRB / ethics systematic review — Wiki.js ID 1724, NocoDB Id 3298). The IRB application checklist is **Robin 第一份 customer-facing template produced from a single deep-read** and consists of: (a) **7 强制要点** [样本来源合法性 + 捐赠者知情同意 + 数据隐私与去标识化 + 共培养产物主体性评估 + 动物福利 3R + 跨境监管合规 + 长期保存与终止使用]; (b) **5 customer Q&A** [类器官研究是否要 IRB 申请 / 类器官共培养产品怎么申请 IRB / 类器官跨境研究怎么报 / 3R 原则怎么写 / 类器官 + 免疫细胞共培养 = CAR-T 体外培养, 算不算新生物体]; (c) **China vs International flow comparison table** [中国 2023 新规 vs 美国 Common Rule vs 欧盟 GDPR]; (d) **10 申请附件清单** [IRB 申请表 + 知情同意书 + 研究方案 + DMP + 样本采集机构 IRB 批件 + ...]; (e) **7 引用** [Guo 2026 + ISSCR 2021 + OHRP 2016 + GDPR + 中国 2023 + 中国 2019 + Cambridge 2020]. **Vendor relevance**: CelVivo ClinoStar ⭐⭐⭐⭐ (the 7 mandatory points directly apply to ClinoStar customer IRB submissions; **Robin 推广 ClinoStar 给三甲医院时, 可附带本框架作为增值**). Tracks as `/commitments.md` `guo-2026-organoid-irb-checklist-rollout` (Owner: me; fold IRB application checklist into CelVivo industrial-customers program + Robin customer-training core material; commit `templates/类器官IRB申请清单.md` and add a synthesis page at `/sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md`).
+
 ## Sales training cluster (working-tree additions)
 
 Per `/sources/git-repo.md` §"Notable entities", `06-Sales/Content/Training-Materials/` contains the following working-tree additions not yet on `main`:
@@ -307,6 +317,8 @@ A dedicated subfolder under `05-Documents/Products/Celvivo/Industrial-Customers/
 
 This is a self-contained CelVivo China commercial effort. The latest mtime census (2026-07-16 snapshot) shows `CelVivo_中国工业客户开发研究报告_20260626_v2.md` as the most-recent file (18 KB, 06-26 11:52). Documented at [`/sources/git-repo.md`](/sources/git-repo.md) §Notable entities.
 
+**2026-08-17 working-tree addition — `celvivo_commercial/1331651_20260630_131201.pdf`** (56 KB, 2026-06-30 quote PDF migrated into a new folder; **untracked**) — companion to the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree. The new folder name signals Robin may be consolidating "Celvivo commercial" documents into a separate vault subtree rather than continuing to nest them under `05-Documents/Products/Celvivo/Industrial-Customers/` (which is the prior convention). If the convention holds, future CelVivo commercial PDFs / quotes / pricing tables will land in `celvivo_commercial/` instead of `05-Documents/Products/Celvivo/Industrial-Customers/`; if it doesn't hold, it's a one-off folder for the 6-30 quote. Watchlist trigger: if a second PDF or commercial doc lands in `celvivo_commercial/` by the next git-repo fetch, the convention change is real; if it stays single-entry, it's a one-off.
+
 ## Work-rhythm snapshot (2026-07-16)
 
 From [`/sources/vault-mtime-snapshot-2026-07-16.md`](/sources/vault-mtime-snapshot-2026-07-16.md) (last full mtime census):
@@ -398,4 +410,7 @@ These are source-anchored but not vendor-anchored — they live here for traceab
 | How does the agent stack consume this output? | [`/themes/03-ai-agents.md`](/themes/03-ai-agents.md) |
 | How does the local-LLM fleet host this evidence? | [`/themes/04-local-llm.md`](/themes/04-local-llm.md) |
 | Where does CelVivo + 3Brain output land? | [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) |
-| Where does Cellink output land? | [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md) ||
\ No newline at end of file
+| Where does Cellink output land? | [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md) |
+| What does Quintard 2024 say about vascularized organoid chips? | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
+| What does Guo 2026 say about organoid IRB ethics? | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
+| What's the IRB application checklist for organoid research? | `templates/类器官IRB申请清单.md` v1.0 (vault path; untracked) ||
\ No newline at end of file