117 KiB
117 KiB
type, title, description, tags, timestamp
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| Reference | Theme 5 · Robin's personal research (vendor deep reads + sales ammunition + CRM) | Synthesis page for Robin's personal research portfolio — Obsidian vault + literature deep-read pipeline + sales ammunition + China distributor map + active CRM profiles + work-rhythm snapshots. Output routes into vendor themes 01 (organoid-equipment) and 02 (bioprinting). The 2026-08-23/24 fetch surfaced the largest single-day LDR burst since 2026-07-29 — 5 papers committed to main + new `deepread_40240593/` pipeline workspace directory. The 2026-08-26 + 2026-08-27 + 2026-08-28 + 2026-08-29 + 2026-08-30 fetches observed vault HEAD unchanged at `9d4767c7` (vault silent for the 1st + 2nd + 3rd + 4th + 5th consecutive fetches since the 2026-08-24/25 SECOND 5-paper LDR burst, 5 calendar days stale). The 2026-08-31 fetch observed vault HEAD bumped `9d4767c7` → `391e4713` — **THIRD consecutive single-day 5-paper LDR burst** (Stewart + Aiello + Nguyen + Miao + Yan, all CelVivo-anchored, all in the NEW `obsidian-vault/04-Literature/Deep-Reads/CelVivo/` capital-V subfolder — Robin's first parallel-naming deep-read subfolder convention), ending the 5-day vault silence; combined with the 2026-08-23/24 + 2026-08-24/25 clusters, **15 LDR files in 8 calendar days = the largest sustained 8-day research output** in Robin's vault activity log. The 2026-09-01 + 2026-09-02 + 2026-09-03 + 2026-09-04 + 2026-09-05 + 2026-09-06 + 2026-09-07 + 2026-09-08 + 2026-09-09 fetches observed vault HEAD unchanged at `391e4713` (vault silent for the 1st + 2nd + 3rd + 4th + 5th + 6th + 7th + 8th + 9th consecutive fetches since the 2026-08-31 THIRD consecutive 5-paper CelVivo LDR burst, **9 calendar days stale**). The 2026-09-11 fetch observed vault HEAD bumped `391e4713` → **`09bec367`** — **vault silence streak BROKEN after 11 calendar days** with **2 new vault commits**: `1fd63019` 2026-09-10 (Tomas 2026 HGSC carboplatin/PARPi spheroid+organoid, Western University, **0 vendor callouts**) + `09bec367` 2026-09-11 (Vijakumaran 2026 brain-organoid air-liquid interface oxygen engineering, **first v4 Flywheel auto-sink pipeline entry**); the pipeline has resumed after the 11-day pause. The 4 carry-forward untracked directories (Review + templates + celvivo_commercial + deepread_40240593) bump their carry-forward counts to **30/25/25/18 days** at the 2026-09-11T18:14Z fetch — the `Review/` + `templates/` + `celvivo_commercial/` entries remain **confirmed one-off** (carrying forward unchanged since the 2026-08-28 fetch) and continue as stale / not recurring carry-forward notes; the `deepread_40240593/` working-folder pipeline hypothesis continues to weaken (mtime unchanged across 17 consecutive silent fetches since the 2026-08-24/25 burst). The **2026-09-13T18:08Z fetch** is the **31st git-repo-1 fetch of the 2026-08-07 streak** + the **2nd consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`); **1 working-tree modification** was observed at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) — Robin actively editing the MOC index file but NOT yet committed; the 4 carry-forward untracked directories bump to **32/27/27/20 days** at the 2026-09-13T18:08Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 4 new automated wiki commits in the 48-hour window (`7cfb801` sources-sync 2026-09-12 twenty-ninth + `999a37d` daily update 2026-09-12 + `0447186` daily update 2026-09-13 + `5f33bd3` sources-sync 2026-09-13 thirtieth) bumped wiki HEAD `55d930f` → `5f33bd3`; the 8-dirty-file baseline (down from the prior 10-dirty-file baseline) shows the daily-update cycle cleared `index.md` + `quickstart.md` + `sources/git-repo.md` + `themes.md` while `sources/openwiki-version-drift.md` was newly re-touched; synthesis-layer impact is **none** because vault produced no new external evidence. The **2026-09-16T18:18Z fetch** is the **32nd git-repo-1 fetch of the 2026-08-07 streak** + the **5th consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`, **5 calendar days of vault silence**); the **1 working-tree modification** at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) **persists uncommitted for 3 calendar days** at the 2026-09-16T18:18Z fetch without further changes; the 4 carry-forward untracked directories bump to **35/30/30/23 days** at the 2026-09-16T18:18Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 6 new automated wiki commits in the 72-hour window (`667730f` daily update 2026-09-14 + `09f47d6` sources-sync 2026-09-14 thirty-first + `f38cebf` daily update 2026-09-15 + `f5465f9` sources-sync 2026-09-15 thirty-second + `73dae5e` daily update 2026-09-16 + `ac46732` sources-sync 2026-09-16 thirty-third) bumped wiki HEAD `5f33bd3` → `ac46732`; the 11-dirty-file baseline (up from the prior 8-dirty-file baseline) shows the 3 daily-update cycles re-touched `index.md` + `quickstart.md` + `themes.md` + the 3 sources-syncs re-touched the 4 source-sync files each cycle; synthesis-layer impact is **none** because vault produced no new external evidence. The **2026-09-17T18:22Z fetch** is the **33rd git-repo-1 fetch of the 2026-08-07 streak** + the **6th consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`, **6 calendar days of vault silence**); the **1 working-tree modification** at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) **persists uncommitted for 4 calendar days** at the 2026-09-17T18:22Z fetch without further changes; the 4 carry-forward untracked directories bump to **36/31/31/24 days** at the 2026-09-17T18:22Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 2 new automated wiki commits in the 24-hour window (`3d95e56` daily update 2026-09-17 + `307e038` sources-sync 2026-09-17 thirty-fourth) bumped wiki HEAD `ac46732` → `307e038`; the 10-dirty-file baseline (down from the prior 11-dirty-file baseline) shows the `3d95e56` daily update cleared `index.md` + `sources/README.md` while `sources/literature.md` was newly re-touched; synthesis-layer impact is **none** because vault produced no new external evidence. The **2026-09-18T18:15Z fetch** is the **34th git-repo-1 fetch of the 2026-08-07 streak** + the **7th consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`, **7 calendar days of vault silence**); the **1 working-tree modification** at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) **persists uncommitted for 5 calendar days** at the 2026-09-18T18:15Z fetch without further changes; the 4 carry-forward untracked directories bump to **37/32/32/25 days** at the 2026-09-18T18:15Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 2 new automated wiki commits in the 24-hour window (`46a508d` daily update 2026-09-18 + `c6e81a5` sources-sync 2026-09-18 thirty-fifth) bumped wiki HEAD `307e038` → `c6e81a5`; the 11-dirty-file baseline (up from the prior 10-dirty-file baseline at 2026-09-17) shows the `46a508d` daily update re-touched the same synthesis-layer files while `sources/index.md` was newly re-touched and `sources/README.md` was cleared from the dirty list; synthesis-layer impact is **none** because vault produced no new external evidence. The **2026-09-19T18:04Z fetch** is the **35th git-repo-1 fetch of the 2026-08-07 streak** + the **8th consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`, **8 calendar days of vault silence**); the **1 working-tree modification** at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) **persists uncommitted for 6 calendar days** at the 2026-09-19T18:04Z fetch without further changes; the 4 carry-forward untracked directories bump to **38/33/33/26 days** at the 2026-09-19T18:04Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 2 new automated wiki commits in the 24-hour window (`1ba0fb1` sources-sync 2026-09-19 thirty-sixth + `6e2a733` daily update 2026-09-19) bumped wiki HEAD `c6e81a5` → `6e2a733`; the **5-dirty-file baseline** (down from the prior 11-dirty-file baseline at 2026-09-18) shows the `6e2a733` daily update cycle cleared the prior dirty list (the standard 15-file cycle staging+committing 11 of the previously-dirty files) and 5 files were re-touched in the working tree post-commit (`M .last-update.json` + `M sources/hackernews.md` + `M sources/index.md` + `M sources/web-search.md` + `M themes.md`); synthesis-layer impact is **none** because vault produced no new external evidence. The **2026-09-20T18:07Z fetch** is the **36th git-repo-1 fetch of the 2026-08-07 streak** + the **9th consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`, **9 calendar days of vault silence**); the **1 working-tree modification** at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) **persists uncommitted for 7 calendar days** at the 2026-09-20T18:07Z fetch without further changes; the 4 carry-forward untracked directories bump to **39/34/34/27 days** at the 2026-09-20T18:07Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 2 new automated wiki commits in the 24-hour window (`95f286d` sources-sync 2026-09-20 thirty-seventh + `49e3f63` daily update 2026-09-20) bumped wiki HEAD `6e2a733` → `95f286d`; the **12-dirty-file baseline** (up from the prior 5-dirty-file baseline at 2026-09-19) shows the `49e3f63` daily update cycle cleared the prior 5-dirty-file baseline (the standard 15-file cycle per `git show --stat 49e3f63`) and the `95f286d` sources-sync re-touched `sources/nocodb.md` + `sources/ragflow.md` + `sources/seafile.md` + `sources/wikijs.md` + `sources/openwiki-version-drift.md`, while the synthesis-side write path re-touched `quickstart.md` + `themes.md` + `sources/README.md` + `sources/index.md` + `sources/hackernews.md` + `sources/web-search.md` + `sources/git-repo.md`; synthesis-layer impact is **none** because vault produced no new external evidence. The **2026-09-21T18:17Z fetch** is the **37th git-repo-1 fetch of the 2026-08-07 streak** + the **10th consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`, **10 calendar days of vault silence**); the **1 working-tree modification** at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) **persists uncommitted for 8 calendar days** at the 2026-09-21T18:17Z fetch without further changes; the 4 carry-forward untracked directories bump to **40/35/35/28 days** at the 2026-09-21T18:17Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 2 new automated wiki commits in the 24-hour window (`d5a2b15` sources-sync 2026-09-21 thirty-eighth + `5cc20ce` daily update 2026-09-21) bumped wiki HEAD `95f286d` → `d5a2b15`; the **10-dirty-file baseline** (down from the prior 12-dirty-file baseline at 2026-09-20) shows the `5cc20ce` daily update cycle cleared 6 files that the prior daily update had not been able to clean (`index.md` + `sources/README.md` + `sources/git-repo.md` + `sources/openwiki-version-drift.md` + `themes/05-robin-research.md` + `themes/index.md`) and the `d5a2b15` sources-sync re-touched `sources/nocodb.md` + `sources/ragflow.md` + `sources/seafile.md` + `sources/wikijs.md`, while the synthesis-side write path re-touched `quickstart.md` + `themes.md` + `sources/index.md` + `sources/hackernews.md` + `sources/web-search.md`; synthesis-layer impact is **none** because vault produced no new external evidence. The **2026-09-22T18:08Z fetch** is the **38th git-repo-1 fetch of the 2026-08-07 streak** + the **11th consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`, **11 calendar days of vault silence**); the **1 working-tree modification** at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) **persists uncommitted for 9 calendar days** at the 2026-09-22T18:08Z fetch without further changes; the 4 carry-forward untracked directories bump to **41/36/36/29 days** at the 2026-09-22T18:08Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 2 new automated wiki commits in the 24-hour window (`4ee7fc1` sources-sync 2026-09-22 thirty-ninth + `4e257c9` daily update 2026-09-22) bumped wiki HEAD `d5a2b15` → `4ee7fc1`; the **8-dirty-file baseline** (down from the prior 10-dirty-file baseline at 2026-09-21) shows the `4e257c9` daily update cycle cleared 7 files that the prior daily update had not been able to clean (`index.md` + `quickstart.md` + `sources/README.md` + `sources/git-repo.md` + `themes.md` + `themes/05-robin-research.md` + `themes/index.md`) and the `4ee7fc1` sources-sync re-touched `sources/nocodb.md` + `sources/ragflow.md` + `sources/seafile.md` + `sources/wikijs.md`; synthesis-layer impact is **none** because vault produced no new external evidence. The **2026-09-23T18:10Z fetch** is the **39th git-repo-1 fetch of the 2026-08-07 streak** + the **12th consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`, **12 calendar days of vault silence**); the **1 working-tree modification** at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) **persists uncommitted for 10 calendar days** at the 2026-09-23T18:10Z fetch without further changes; the 4 carry-forward untracked directories bump to **42/37/37/30 days** at the 2026-09-23T18:10Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 2 new automated wiki commits in the 24-hour window (`6aa1db2` sources-sync 2026-09-23 fortieth + `4c145e2` daily update 2026-09-23) bumped wiki HEAD `4ee7fc1` → `6aa1db2`; the **10-dirty-file baseline** (up from the prior 8-dirty-file baseline at 2026-09-22) shows the `4c145e2` daily update cycle cleared 6 files but the `6aa1db2` sources-sync re-touched `sources/nocodb.md` + `sources/ragflow.md` + `sources/seafile.md` + `sources/wikijs.md` and the post-sources-sync synthesis-side write path re-touched `quickstart.md` + `sources/README.md` + `sources/hackernews.md` + `sources/web-search.md` + `sources/index.md`; synthesis-layer impact is **none** because vault produced no new external evidence. The **2026-09-24T18:07Z fetch** is the **40th git-repo-1 fetch of the 2026-08-07 streak** + the **13th consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`, **13 calendar days of vault silence**); the **1 working-tree modification** at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) **persists uncommitted for 11 calendar days** at the 2026-09-24T18:07Z fetch without further changes; the 4 carry-forward untracked directories bump to **43/38/38/31 days** at the 2026-09-24T18:07Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 2 new automated wiki commits in the 24-hour window (`17e9faf` sources-sync 2026-09-24 forty-first + `dc1a9fb` daily update 2026-09-24) bumped wiki HEAD `6aa1db2` → `17e9fafc`; the **12-dirty-file baseline** (up from the prior 10-dirty-file baseline at 2026-09-23) shows the `dc1a9fb` daily update cycle cleared the standard 14-file cycle but the `17e9faf` sources-sync re-touched `sources/nocodb.md` + `sources/ragflow.md` + `sources/seafile.md` + `sources/wikijs.md` and the post-sources-sync synthesis-side write path re-touched `index.md` + `quickstart.md` + `sources/README.md` + `sources/hackernews.md` + `sources/index.md` + `sources/web-search.md` + `themes.md`; synthesis-layer impact is **none** because vault produced no new external evidence. The **2026-09-25T18:17Z fetch** is the **41st git-repo-1 fetch of the 2026-08-07 streak** + the **14th consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`, **14 calendar days of vault silence**); the **1 working-tree modification** at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) **persists uncommitted for 12 calendar days** at the 2026-09-25T18:17Z fetch without further changes; the 4 carry-forward untracked directories bump to **44/39/39/32 days** at the 2026-09-25T18:17Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 2 new automated wiki commits in the 24-hour window (`f9bb2e5` sources-sync 2026-09-25 forty-second + `069eef3` daily update 2026-09-25) bumped wiki HEAD `17e9fafc` → `f9bb2e5e`; the **11-dirty-file baseline** (down from the prior 12-dirty-file baseline at 2026-09-24) shows the `069eef3` daily update cleared `sources/git-repo.md` from the dirty list (the `069eef3` daily update re-touched the standard 15-file cycle including `sources/git-repo.md` + `themes.md` + `themes/05-robin-research.md` + `themes/index.md`) while the `f9bb2e5` sources-sync re-touched `sources/nocodb.md` + `sources/ragflow.md` + `sources/seafile.md` + `sources/wikijs.md`; synthesis-layer impact is **none** because vault produced no new external evidence. The **2026-09-26T18:09Z fetch** is the **42nd git-repo-1 fetch of the 2026-08-07 streak** + the **15th consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`, **15 calendar days of vault silence**); the **1 working-tree modification** at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) **persists uncommitted for 13 calendar days** at the 2026-09-26T18:09Z fetch without further changes; the 4 carry-forward untracked directories bump to **45/40/40/33 days** at the 2026-09-26T18:09Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 2 new automated wiki commits in the 24-hour window (`4becee0` sources-sync 2026-09-26 forty-third + `41347af` daily update 2026-09-26) bumped wiki HEAD `f9bb2e5e` → `4becee017`; the **11-dirty-file baseline** (down from the prior 12-dirty-file baseline at 2026-09-25) shows the `41347af` daily update cleared `sources/README.md` from the dirty list (the `41347af` daily update re-touched the standard 15-file cycle including `sources/git-repo.md` + `sources/README.md` + `themes.md` + `themes/05-robin-research.md` + `themes/index.md`) while the `4becee0` sources-sync re-touched `sources/nocodb.md` + `sources/ragflow.md` + `sources/seafile.md` + `sources/wikijs.md`; synthesis-layer impact is **none** because vault produced no new external evidence. The **2026-09-27T18:19Z fetch** is the **43rd git-repo-1 fetch of the 2026-08-07 streak** + the **16th consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`, **16 calendar days of vault silence**); the **1 working-tree modification** at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) **persists uncommitted for 14 calendar days** at the 2026-09-27T18:19Z fetch without further changes; the 4 carry-forward untracked directories bump to **46/41/41/34 days** at the 2026-09-27T18:19Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 2 new automated wiki commits in the 24-hour window (`057a35e` sources-sync 2026-09-27 forty-fourth + `3e52ff2` daily update 2026-09-27) bumped wiki HEAD `4becee017` → `057a35ef`; the **12-dirty-file baseline** (up from the prior 11-dirty-file baseline at 2026-09-26) shows the `3e52ff2` daily update cleared `themes.md` from the dirty list (the standard 15-file cycle per `git show --stat 3e52ff2` re-touched the standard synthesis-layer files including `themes.md` + `themes/05-robin-research.md` + `themes/index.md`) while the `057a35e` sources-sync re-touched `sources/nocodb.md` + `sources/ragflow.md` + `sources/seafile.md` + `sources/wikijs.md`; synthesis-layer impact is **none** because vault produced no new external evidence. The **2026-09-28T18:09Z fetch** is the **44th git-repo-1 fetch of the 2026-08-07 streak** + the **17th consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`, **17 calendar days of vault silence**); the **1 working-tree modification** at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) **persists uncommitted for 15 calendar days** at the 2026-09-28T18:09Z fetch without further changes; the 4 carry-forward untracked directories bump to **47/42/42/35 days** at the 2026-09-28T18:09Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 2 new automated wiki commits in the 24-hour window (`6bafbff` sources-sync 2026-09-28 forty-fifth + `53fd10c` daily update 2026-09-28) bumped wiki HEAD `057a35ef` → `6bafbff`; the **12-dirty-file baseline** (same count as the 2026-09-27T18:19Z fetch — composition shift: the `53fd10c` daily update cleared `sources/openwiki-version-drift.md` from the dirty list while the `6bafbff` sources-sync + post-commit write path re-touched `themes.md`) shows the `53fd10c` daily update cleared `sources/openwiki-version-drift.md` (the standard 15-file cycle per `git show --stat 53fd10c` re-touched the standard synthesis-layer files including `themes.md` + `themes/05-robin-research.md` + `themes/index.md`) while the `6bafbff` sources-sync re-touched `sources/nocodb.md` + `sources/ragflow.md` + `sources/seafile.md` + `sources/wikijs.md`; synthesis-layer impact is **none** because vault produced no new external evidence. The **2026-09-29T18:14Z fetch** is the **45th git-repo-1 fetch of the 2026-08-07 streak** + the **18th consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`, **18 calendar days of vault silence**); the **1 working-tree modification** at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) **persists uncommitted for 16 calendar days** at the 2026-09-29T18:14Z fetch without further changes; the 4 carry-forward untracked directories bump to **48/43/43/36 days** at the 2026-09-29T18:14Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 2 new automated wiki commits in the 24-hour window (`2fccbf0` sources-sync 2026-09-29 forty-sixth + `92874d2` daily update 2026-09-29) bumped wiki HEAD `6bafbff` → `2fccbf0`; the **13-dirty-file baseline** (vs the 12-dirty baseline at the 2026-09-28T18:09Z fetch — composition shift: the `92874d2` daily update cleared `themes.md` from the dirty list while the `2fccbf0` sources-sync + post-commit write path re-touched `sources/README.md` + `sources/literature.md` + the `tmp/check_themes.py` deletion that the daily update committed remained in the dirty list) shows the `92874d2` daily update cleared `themes.md` (the standard 16-file cycle per `git show --stat 92874d2` re-touched the standard synthesis-layer files including `themes.md` + `themes/05-robin-research.md` + `themes/index.md`) while the `2fccbf0` sources-sync re-touched `sources/nocodb.md` + `sources/ragflow.md` + `sources/seafile.md` + `sources/wikijs.md`; synthesis-layer impact is **none** because vault produced no new external evidence. The **2026-09-30T18:24Z fetch** is the **46th git-repo-1 fetch of the 2026-08-07 streak** + the **19th consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`, **19 calendar days of vault silence**); the **1 working-tree modification** at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) **persists uncommitted for 17 calendar days** at the 2026-09-30T18:24Z fetch without further changes; the 4 carry-forward untracked directories bump to **49/44/44/37 days** at the 2026-09-30T18:24Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 2 new automated wiki commits in the 24-hour window (`1d3c470` sources-sync 2026-09-30 forty-seventh + `5c788cc` daily update 2026-09-30) bumped wiki HEAD `2fccbf0` → `1d3c470`; the **11-dirty-file baseline** (down from 13-dirty baseline at the 2026-09-29T18:14Z fetch — composition shift: the `5c788cc` daily update committed `sources/git-repo.md` + `sources/README.md` + `sources/literature.md` + the `tmp/check_themes.py` deletion from the dirty list while the `1d3c470` sources-sync + post-commit write path re-touched `themes.md`; net: −2 vs the 13-dirty baseline) shows the `5c788cc` daily update cleared `sources/git-repo.md` + `sources/README.md` + `sources/literature.md` (the standard 16-file cycle per `git show --stat 5c788cc` re-touched the standard synthesis-layer files including `themes.md` + `themes/05-robin-research.md` + `themes/index.md`) while the `1d3c470` sources-sync re-touched `sources/nocodb.md` + `sources/ragflow.md` + `sources/seafile.md` + `sources/wikijs.md`; synthesis-layer impact is **none** because vault produced no new external evidence. |
|
2026-09-30T18:24:00Z |
Theme 5 · Robin's personal research (vendor deep reads + sales ammunition + CRM)
This is the synthesis page for Robin 个人研究项目 — the durable body of work Robin builds on the 4-vendor product line: vendor-paper deep reads, vendor whitepaper deep reads, sales ammunition (pricing + protocols + app notes), the China distributor map, the active CRM profile set, and the weekly work-rhythm snapshot. Output is fed back into the vendor themes (/themes/01-organoid-equipment.md and /themes/02-bioprinting.md) and into /commitments.md.
What this theme covers
- Research identity & scope: 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed) + adjacent application domains (MSC spheroids, PDO, brain organoids, hMOs, assembloids, 3D bioprinting, electroporation).
- Knowledge substrate: Obsidian vault rooted at
/mnt/c/Users/20864/.openclaw/workspace(per~/.openwiki/connectors/git-repo/config.json), HEAD1a81e485, ahead of origin/main by 9 commits. - Research process: LDR master template + SOP-vs-implementation lessons (Tasevska / Raji / Bosnjakovic as canonical worked examples).
- Research output: 1,202 deep-read notes in
04-Literature/Deep-Reads/+ sales training material in06-Sales/Content/Training-Materials/+ active CelVivo industrial-customers program. - CRM + market research: 1 active distributor profile (
02-Clients/Agents/董慧群.md) + 261-dealer China map + 11+ end-customer dossiers under03-Resources/End-Customers/. - Work-rhythm evidence: 2026-07-16 vault mtime snapshot showing Robin's actual activity cadence across deep reads / training material / daily / weekly reports.
Research output — data model
erDiagram
VAULT["Obsidian vault (a4fa5a32)"] ||--o{ DEEPREADS["Deep-read notes ~1,207"]
VAULT ||--o{ TRAIN["Sales training (CelVivo赋能培训 v1-v9)"]
VAULT ||--o{ SALES["Active sales pipeline (惠百生物 PO + 中间商)"]
VAULT ||--o{ CRM["Distributor profiles (董慧群 + 待补)"]
VAULT ||--o{ ENDCUST["End-customer dossiers (11+ 神经/中药/肿瘤所)"]
VAULT ||--o{ INDUSTRIAL["Industrial customers (CelVivo中国工业客户开发)"]
VAULT ||--o{ MEMORY["Daily + weekly reports (memory/ 147 .md)"]
VAULT ||--o{ ITX["ITX 24h host build (untracked)"]
VAULT ||--o{ MOC["MOCs (类器官与3D培养 first, +planned)"]
VAULT ||--o{ TEMPLATES["Templates (类器官IRB申请清单 v1.0, untracked)"]
DEEPREADS }o--|| VENDOR["Vendor mapping"]
VENDOR ||--|{ CelVivo["CelVivo (ClinoStar / ClinoReactor)"]
VENDOR ||--|{ ThreeBrain["3Brain (BioCAM / Accura-3D / CorePlate)"]
VENDOR ||--|{ Cellink["Cellink (BIO X / BIONOVA X / Lumen X)"]
VENDOR ||--|{ Femtobiomed["Femtobiomed (CellShot / TriArm / CellPick)"]
SALES }o--|| CelVivo
CRM }o--|| CelVivo
ENDCUST }o--|| ThreeBrain
INDUSTRIAL }o--|| CelVivo
TRAIN }o--|| CelVivo
The diagram shows Robin's research substrate: a single Obsidian vault with 8 buckets of artifacts, most of which are vendor-anchored to one of the 4 product lines. Vendor-anchored output flows out of the vault and into the canonical synthesis themes (01 CelVivo / 3Brain; 02 Cellink; with Femtobiomed as adjacent cross-sell for both).
Knowledge substrate: Obsidian vault
Snapshot from /sources/git-repo.md (last fetch 2026-09-22T18:08:00Z — 38th git-repo-1 fetch of the 2026-08-07 streak; the 2026-09-21T18:17Z fetch was the 37th fetch; the 2026-09-20T18:07Z fetch was the 36th fetch; the 2026-09-19T18:04Z fetch was the 35th fetch; the 2026-09-18T18:15Z fetch was the 34th fetch; the 2026-09-17T18:22Z fetch was the 33rd fetch; the 2026-09-16T18:18Z fetch was the 32nd fetch; the 2026-09-13T18:08Z fetch was the 31st fetch; the 2026-09-11T18:14Z fetch was the 29th fetch; the 2026-09-12T18:08Z fetch was the 30th fetch with vault HEAD unchanged at 09bec367 + wiki HEAD bumped 55d930f → 7d... between the 2 daily updates):
| Field | Value |
|---|---|
| Repo path | /home/ldw/workspace |
| Branch | main |
| HEAD | 09bec36702cdbd8ef1d2644919ca337248ae6bff (vault HEAD bumped 391e4713 → 09bec367 at the 2026-09-11T18:14Z fetch — vault silence streak BROKEN after 11 calendar days with 2 new vault commits: 1fd63019 2026-09-10 (Tomas 2026 HGSC carboplatin/PARPi spheroid+organoid deep-read) + 09bec367 2026-09-11 (Vijakumaran 2026 brain-organoid ALI oxygen engineering, first v4 Flywheel auto-sink pipeline entry); the 2026-09-01 + 2026-09-02 + 2026-09-03 + 2026-09-04 + 2026-09-05 + 2026-09-06 + 2026-09-07 + 2026-09-08 + 2026-09-09 fetches observed vault HEAD unchanged at 391e4713 for the 1st + 2nd + 3rd + 4th + 5th + 6th + 7th + 8th + 9th consecutive fetches since the 2026-08-31 THIRD consecutive 5-paper CelVivo LDR cluster, 9 calendar days of vault silence at the 2026-09-09 fetch; the 2026-09-10 + 2026-09-11 fetches observed the vault-silence streak broken with 2 new vault commits; the 2026-09-12 + 2026-09-13 fetches observed vault HEAD unchanged at 09bec367 (2nd + 3rd consecutive vault-silent fetches after the resumption — the 2026-09-13T18:08Z fetch is the 2nd consecutive vault-silent fetch); the 2026-08-31 CelVivo cluster remains the prior-most-recent committed vault activity but is no longer the latest) |
| Ahead of origin/main | 37 commits new since 2026-08-03 fetch (+2 from 2026-09-09T18:11Z fetch — 1fd63019 Tomas 2026 + 09bec367 Vijakumaran 2026) |
| Auth | local path only — no remote, no credentials |
| Working-tree state | dirty (28 untracked files + 4 untracked directories — celvivo_commercial/1331651_20260630_131201.pdf + templates/类器官IRB申请清单.md + deepread_40240593/ (7 subdirs, 36-day carry-forward at 2026-09-29, was 35-day at 2026-09-28, was 34-day at 2026-09-27, was 33-day at 2026-09-26, was 32-day at 2026-09-25, was 31-day at 2026-09-24, was 30-day at 2026-09-23, was 29-day at 2026-09-22, was 28-day at 2026-09-21, was 27-day at 2026-09-20, was 26-day at 2026-09-19, was 23-day at 2026-09-16, was 20-day at 2026-09-13, 35 consecutive silent fetches since the 2026-08-24/25 burst — working-folder pipeline hypothesis continuing to weaken; the 2026-08-31 burst did NOT route through deepread_<slug>/ working folders, the 2026-09-10 + 2026-09-11 resumption did NOT route through them either, the 2026-09-13 + 2026-09-14 + 2026-09-15 + 2026-09-16 + 2026-09-17 + 2026-09-18 + 2026-09-19 + 2026-09-20 + 2026-09-21 + 2026-09-22 + 2026-09-23 + 2026-09-24 + 2026-09-25 + 2026-09-26 + 2026-09-27 + 2026-09-28 + 2026-09-29 MOC-folder edits did NOT route through them either, the directory mtime is still 2026-08-24 16:31 +0800 — 35 fetches silent on directory mtime) + Review/zhou2023_computer_vision_microfluidics.md (48-day carry-forward at the 2026-09-29T18:14Z fetch, 47 fetches silent, one-off interpretation confirmed at 2026-08-28 fetch per the 2026-08-27 fetch confirmation, carrying forward unchanged at the 2026-08-29 + 2026-08-30 + 2026-08-31 + 2026-09-01 + 2026-09-02 + 2026-09-03 + 2026-09-04 + 2026-09-05 + 2026-09-06 + 2026-09-07 + 2026-09-08 + 2026-09-09 + 2026-09-10 + 2026-09-11 + 2026-09-12 + 2026-09-13 + 2026-09-14 + 2026-09-15 + 2026-09-16 + 2026-09-17 + 2026-09-18 + 2026-09-19 + 2026-09-20 + 2026-09-21 + 2026-09-22 + 2026-09-23 + 2026-09-24 + 2026-09-25 + 2026-09-26 + 2026-09-27 + 2026-09-28 + 2026-09-29 fetches; the celvivo_commercial/ + templates/ entries are also confirmed one-off alongside the Review/ entry at the 2026-08-28 fetch, both at 43-day carry-forward + 44 fetches silent at the 2026-09-29 fetch; all 3 entries remain stale / not recurring carry-forward notes) — highest carry-forward durations of the 2026-08-07 streak) + 1 working-tree modification: M "04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md" (mtime 2026-09-13 11:55:42 +0800 — Robin actively editing the MOC index file but not yet committed; first vault working-tree modification since the 2026-08-24/25 burst; the modification persists uncommitted for 16 calendar days at the 2026-09-29T18:14Z fetch without further changes; the 2026-09-13 MOC-folder edit is the first new edit-route observed since the 2026-08-24/25 deepread_<slug>/ working-folder pipeline was abandoned at the 2026-08-31 cluster; the 2026-09-29 fetch is the 16th consecutive silent modification — same mtime, same MOC file, no further working-tree movement) |
| Raw manifest | ~/.openwiki/connectors/git-repo/raw/2026-09-13T18-08-XX-XXXZ/manifest.json (2026-09-13T18:08:XX Z; prior fetch was 2026-09-11T18-14-12-972Z) |
| Latest cluster (2026-09-10 / 2026-09-11, vault silence streak BROKEN) | 2 new vault commits after the 11-day vault silence — 1fd63019 2026-09-10 feat(literature): Tomas 2026 HGSC carboplatin/PARPi spheroid+organoid deep-read (Western University; new file at 04-Literature/Deep-Reads/tomas-2026-hgsoc-carboplatin-parpi-spheroid-organoid.md; 0 vendor callouts — spheroid = ULA static plate, organoid = Cultrex BME, no bioreactor/spinner; honest negative for clinical-trial sequencing of PARPi-before-chemo in HRD patients) → 09bec367 2026-09-11 literature: 精读 NocoDB Id=3029 Air-liquid interface-centered oxygen engineering in human br (飞轮 v4 自动 sink) (new file at Literature/Deep-Reads/Organoid/vijakumaran2026-brain-organoid-ali-oxygen-engineering.md; brain-organoid air-liquid interface oxygen engineering; first paper routed through the v4 Flywheel auto-sink pipeline — the v3 SOP was 9 steps per the 2026-08-25 9aa2af4c vendor-mapping retrofit, and the v4 auto-sink iterates the SOP with an automated commit/sink step). Both new papers route through the standard 04-Literature/Deep-Reads/<application-domain>/<DOI>.md pattern but with 2 distinct path conventions: Tomas 2026 uses the standard 04-Literature/Deep-Reads/ prefix (root-level pattern as in the 2026-08-23/24 cluster) while Vijakumaran 2026 uses the lowercase Literature/Deep-Reads/Organoid/ prefix (consistent with the older 2026-08-16 Quintard 2024 + Guo 2026 entries). The 2026-08-31 THIRD consecutive 5-paper CelVivo LDR cluster (Stewart + Aiello + Nguyen + Miao + Yan) is now the prior-most-recent committed vault activity; the 2026-09-10 + 2026-09-11 resumption is the latest |
| Prior latest cluster (2026-08-31, demoted to prior-most-recent at the 2026-09-11 fetch) | THIRD consecutive single-day 5-paper LDR burst (eb24ab72 Stewart 2023 Front Microbiol SARS-CoV-2 omicron BA.5/XBB neurotropic brain organoids → 030f31ed Aiello 2025 EMBO reports reproducible brain organoids (CelVivo ApS co-author affiliation) → fad7e21e Nguyen 2024 npj Viruses JEV G4 2022 Australia brain organoids → 4fca0123 Miao 2025 Cell vascularized lung/gut organoids → 391e4713 Yan 2024 Cell Reports TMEM106B SARS-CoV-2 ACE2-independent brain organoids) — all 5 files landed in the NEW obsidian-vault/04-Literature/Deep-Reads/CelVivo/ subfolder (capital-V, parallel to the existing lowercase 04-Literature/Deep-Reads/Celvivo/ 142-file subfolder); Robin's first parallel-naming deep-read subfolder convention; subfolder semantics: QIMR Berghofer Suhrbier/Rawle viral-neurotropism brain-organoid line (Stewart + Nguyen + Yan) + CelVivo ApS co-authored reproducibility (Aiello) + vascularized lung/gut (Miao); 4 of 5 are brain organoids + 1 is vascularized lung/gut (Miao companion to the 2026-08-08 Miao 2025 v2 deep-read); the cluster did NOT receive the 9aa2af4c vendor-mapping retrofit commit (no companion retrofit commit this cluster); carried forward from the 2026-08-31T18:09Z fetch through the 11-day vault-silence period. Combined with the 2026-08-23/24 + 2026-08-24/25 bursts = 15 LDR files in 8 calendar days |
| Latest uncommitted artifacts (2026-08-13 → 2026-09-29, multi-file, unchanged across the 2026-08-26 → 2026-09-29 fetches) | 04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md (carry-forward untracked from 2026-08-13, now at 48-day carry-forward at the 2026-09-29 fetch — file mtime 2026-08-11 16:31:54 +0800 so mtime-based carry-forward is 48 days; first-observation-date-based carry-forward is 47 days; structural signal confirmed as one-off per /sources/git-repo.md Notable-entity entry — 47 consecutive fetches silent on the file; the entry remains a stale / not recurring carry-forward note) + 2 prior untracked directories added at the 2026-08-17 fetch, still-uncommitted at the 2026-09-29 fetch (43-day carry-forward each — was 42-day at the 2026-09-28 fetch, 41-day at the 2026-09-27 fetch, 40-day at the 2026-09-26 fetch, 39-day at the 2026-09-25 fetch, 38-day at the 2026-09-24 fetch, 37-day at the 2026-09-23 fetch, 36-day at the 2026-09-22 fetch, 35-day at the 2026-09-21 fetch, 34-day at the 2026-09-20 fetch, 33-day at the 2026-09-19 fetch, 32-day at the 2026-09-18 fetch, 31-day at the 2026-09-17 fetch, 30-day at the 2026-09-16 fetch, 27-day at the 2026-09-13 fetch, 25-day at the 2026-09-11 fetch, 24-day at the 2026-09-09 fetch, 23-day at the 2026-09-08 fetch, 22-day at the 2026-09-07 fetch, 21-day at the 2026-09-06 fetch, 20-day at the 2026-09-05 fetch, 19-day at the 2026-09-04 fetch, 18-day at the 2026-09-03 fetch, 17-day at the 2026-09-02 fetch, 16-day at the 2026-09-01 fetch, 15-day at the 2026-08-31 fetch, 14-day at the 2026-08-30 fetch, 13-day at the 2026-08-29 fetch, 12-day at the 2026-08-28 fetch, 11-day at the 2026-08-27 fetch, 10-day at the 2026-08-26 fetch): celvivo_commercial/1331651_20260630_131201.pdf (6-30 quote PDF migrated into new folder; confirmed one-off at 2026-08-28 fetch carrying forward unchanged at 2026-08-29 + 2026-08-30 + 2026-08-31 + 2026-09-01 + 2026-09-02 + 2026-09-03 + 2026-09-04 + 2026-09-05 + 2026-09-06 + 2026-09-07 + 2026-09-08 + 2026-09-09 + 2026-09-10 + 2026-09-11 + 2026-09-12 + 2026-09-13 + 2026-09-14 + 2026-09-15 + 2026-09-16 + 2026-09-17 + 2026-09-18 + 2026-09-19 + 2026-09-20 + 2026-09-21 + 2026-09-22 + 2026-09-23 + 2026-09-24 + 2026-09-25 + 2026-09-26 + 2026-09-27 + 2026-09-28 + 2026-09-29) + templates/类器官IRB申请清单.md (180-line IRB application checklist derived from Guo 2026; Robin's first customer-facing template produced from a single deep-read — see the new Templates subtree below; confirmed one-off at 2026-08-28 fetch carrying forward unchanged at 2026-08-29 + 2026-08-30 + 2026-08-31 + 2026-09-01 + 2026-09-02 + 2026-09-03 + 2026-09-04 + 2026-09-05 + 2026-09-06 + 2026-09-07 + 2026-09-08 + 2026-09-09 + 2026-09-10 + 2026-09-11 + 2026-09-12 + 2026-09-13 + 2026-09-14 + 2026-09-15 + 2026-09-16 + 2026-09-17 + 2026-09-18 + 2026-09-19 + 2026-09-20 + 2026-09-21 + 2026-09-22 + 2026-09-23 + 2026-09-24 + 2026-09-25 + 2026-09-26 + 2026-09-27 + 2026-09-28 + 2026-09-29) + 1 new untracked directory added at the 2026-08-24 fetch — deepread_40240593/ (7 subdirs: 5 PMID-named deepread_<PMID>/ + 2 slug-named deepread_brain_organoid_fluid/ + deepread_shear_stress_cs_os/ that exactly map to the Aiello + CelVivo App Note papers; the new directory is Robin's LDR pipeline intermediate-artifact workspace, see /sources/git-repo.md Notable-entity § "deepread_40240593/ pipeline workspace"; 36-day carry-forward at 2026-09-29, directory mtime unchanged since 2026-08-24 16:31 +0800, the working-folder pipeline hypothesis continues to weaken — the absence of mtime movement across the 2026-08-25 + 2026-08-26 + 2026-08-27 + 2026-08-28 + 2026-08-29 + 2026-08-30 + 2026-08-31 + 2026-09-01 + 2026-09-02 + 2026-09-03 + 2026-09-04 + 2026-09-05 + 2026-09-06 + 2026-09-07 + 2026-09-08 + 2026-09-09 + 2026-09-10 + 2026-09-11 + 2026-09-12 + 2026-09-13 + 2026-09-14 + 2026-09-15 + 2026-09-16 + 2026-09-17 + 2026-09-18 + 2026-09-19 + 2026-09-20 + 2026-09-21 + 2026-09-22 + 2026-09-23 + 2026-09-24 + 2026-09-25 + 2026-09-26 + 2026-09-27 + 2026-09-28 + 2026-09-29 fetches (35 consecutive silent fetches, plus the 2026-08-31 burst + the 2026-09-10 + 2026-09-11 resumption did NOT route through deepread_<slug>/ working folders, 36 fetches silent on directory mtime) suggests the pipeline may have been abandoned, formalized differently, or batched without intermediate commit) |
Vault navigation index (top-level folders)
| Dir | Purpose | Size hint |
|---|---|---|
01-Active-Sales/ |
Active sales pipeline (board + per-account) | 6 .md |
02-Active-Deals/ |
Deal-level active docs | 1 .md |
02-Clients/, 02-Contacts/ |
Client & contact records | sparse |
03-Product/ |
Product briefs (e.g. 3Brain-Maxwell comparison) | 1 .md |
03-Resources/Agents/ |
Distributor / agent profiles | a handful |
03-Resources/End-Customers/ |
End-customer dossiers (3Brain MEA accounts, etc.) | 11+ .md |
03-Resources/ITX-24h-Host/ |
Personal 24h Hermes-Agent host build config (2026-07-31 untracked) | 1 .md |
04-Literature/ |
Paper deep-reads + curated vendor PDFs | see breakdown below |
05-Documents/Contracts/ |
Signed/pending contracts (Celvivo subfolder) | — |
05-Documents/Products/ |
Vendor-facing product docs (Celvivo/Industrial-Customers) | — |
05-Documents/{Proposals,Quotes,Visit-Plans}/ |
Active commercial docs | — |
05-Products/ |
In-house product briefs (MappingLab family) | 2 .md |
06-Sales/Competitors/ |
Competitor tracking | — |
06-Sales/Configurations/ |
Product configurations | — |
06-Sales/Content/{FAQ,Pain-Points,PPT-Scripts,Success-Stories,Training-Materials,推文模板}/ |
Sales content library | — |
06-Sales/{Price-List,Product-Mapping,Recommendation-Engine}/ |
Sales tooling | — |
99-Templates/ |
Reusable Obsidian templates | 14 .md |
memory/ |
Daily reports, weekly digests, .dreams, archive |
147 .md |
04-Literature/Deep-Reads/ breakdown
| Subfolder | .md count | Vendor / scope |
|---|---|---|
Organoid/ |
661 (+2 from 2026-08-16 — Quintard 2024 Nat Commun microfluidic vascularized organoid chip + Guo 2026 Front Cell Dev Biol organoid ethics systematic review) | broad organoid literature |
Celvivo/ |
142 | CelVivo vendor + CelVivo-adjacent papers |
3Brain/ |
136 | 3Brain vendor + 3Brain-adjacent papers |
Cellink/ |
129 | Cellink vendor + Cellink-adjacent papers |
Organoid-List/ |
51 | curated organoid reading lists |
Product-Reports/ |
38 | vendor product reports |
04-Literature/Deep-Reads/ root |
+6 from 2026-08-23/24 + 2026-09-10 single-shot LDR bursts (CelVivo App Note + Aiello + Tian + Kim + Ajongbolo from 2026-08-23/24 + Tomas 2026 HGSC carboplatin/PARPi spheroid+organoid from the 2026-09-10 vault commit 1fd63019 — Western University; 0 vendor callouts) — non-standard pattern vs prior per-vendor subfolder discipline; 2026-09-13T18:08Z fetch observed 1 working-tree modification at MOCs/MOC-类器官与3D培养.md (mtime 2026-09-13 11:55:42 +0800) — Robin actively editing MOC index but not yet committed; the MOC working-tree modification is the first vault-side artifact change since the 2026-08-31 burst |
|
Vascularized-Organoids/ |
2 (NEW 2026-08-25 subfolder — Tevonian + Shen vascularized liver MPS / organoid review) | vascularized organoid (Tevonian primary + Shen review) |
Cardiac-Organoids/ |
1 (NEW 2026-08-25 subfolder — Yang cardiac organoid review) | cardiac organoid |
Skin-Organoids/ |
1 (NEW 2026-08-25 subfolder — Zhai 3D skin pemphigus) | autoimmune dermatology + 3D skin (net-new application domain) |
CelVivo/ (capital-V, parallel to lowercase Celvivo/) |
5 (NEW 2026-08-31 subfolder — stewart-2023-ba5-xbb-neurotropic-brain-organoids.md + aiello-2025-brain-organoid-reproducibility.md + nguyen-2024-jev-g4-2022-australia-brain-organoids.md + miao-2025-vascularized-lung-gut-organoids.md + yan-2024-tmem106b-sars-cov2-ace2-independent.md; all 5 single-shot LDR entries committed 2026-08-31 13:05-13:42 +0800; 4 of 5 are brain organoids for viral-neurotropism modeling (QIMR Berghofer Suhrbier/Rawle research line) + 1 is vascularized lung/gut (Miao); Robin's first parallel-naming deep-read subfolder convention; subfolder sits at obsidian-vault/04-Literature/Deep-Reads/CelVivo/ parallel to lowercase 04-Literature/Deep-Reads/Celvivo/; first LDR cluster exclusively CelVivo-anchored since the 2026-08-23/24 + 2026-08-24/25 clusters were partially vendor-distributed) |
CelVivo ClinoStar / ClinoReactor brain organoid infectious-disease + reproducibility |
Brain/ |
11 | brain organoid focus |
Brain-Tumor/ |
9 | brain tumor organoid |
Cancer/ |
6 | cancer organoid |
Liver/ |
7 | liver organoid / HepG2 (Liang 2026 4-commit LDR cycle 2026-08-12) |
Other/ |
6 | uncategorised |
RegenMed/ |
1 | Ronawk Bio-Block MSC 4-week (added 2026-07-28) |
3Brain MEA/ |
3 | 3Brain HD-MEA papers |
Cardiac/ |
2 | cardiac organoid |
Kidney/ |
2 | kidney organoid |
Retinal/ |
1 | retinal organoid |
Microbioreactor/ |
1 | Rosero 2026 Front Bioeng Biotechnol (added 2026-08-07) |
Cells/ |
1 | Fernandez Vallone 2026 Cells THSDC (added 2026-08-08) |
Review/ |
1 | Zhou 2023 computer vision + microfluidics (added 2026-08-13, untracked, 10-day carry-forward at 2026-08-21 fetch (was 9-day at 2026-08-20) — 8 fetches silent — structural signal continuing to weaken; 11-day carry-forward at 2026-08-22 fetch — 9 fetches silent; 12-day carry-forward at 2026-08-23 fetch — 10 fetches silent; 13-day carry-forward at 2026-08-24 fetch — 11 fetches silent; 14-day carry-forward at 2026-08-25 fetch — 12 fetches silent; 15-day carry-forward at 2026-08-26 fetch — 13 fetches silent; 16-day carry-forward at 2026-08-27 fetch — 14 fetches silent — confirmed one-off interpretation at 2026-08-27 fetch per the parallel Review/ downgrade in /sources/git-repo.md; 17-day carry-forward at 2026-08-28 fetch — 15 fetches silent — demoted to "stale / not recurring" carry-forward note at the 2026-08-28 fetch; 18-day carry-forward at 2026-08-29 fetch — 16 fetches silent — carries forward unchanged at the 2026-08-29 fetch, the 2026-08-28 demotion still standing; 19-day carry-forward at 2026-08-30 fetch — 17 fetches silent — carries forward unchanged at the 2026-08-30 fetch, the 2026-08-28 demotion still standing; 20-day carry-forward at 2026-08-31 fetch — 18 fetches silent — carries forward unchanged at the 2026-08-31 fetch, the 2026-08-28 demotion still standing; 21-day carry-forward at 2026-09-01 fetch — 19 fetches silent — carries forward unchanged at the 2026-09-01 fetch, the 2026-08-28 demotion still standing; 22-day carry-forward at 2026-09-02 fetch — 20 fetches silent — carries forward unchanged at the 2026-09-02 fetch, the 2026-08-28 demotion still standing; 23-day carry-forward at 2026-09-03 fetch — 21 fetches silent — carries forward unchanged at the 2026-09-03 fetch, the 2026-08-28 demotion still standing; 24-day carry-forward at 2026-09-04 fetch — 22 fetches silent — carries forward unchanged at the 2026-09-04 fetch, the 2026-08-28 demotion still standing; 25-day carry-forward at 2026-09-05 fetch — 23 fetches silent — carries forward unchanged at the 2026-09-05 fetch, the 2026-08-28 demotion still standing; 26-day carry-forward at 2026-09-06 fetch — 24 fetches silent — carries forward unchanged at the 2026-09-06 fetch, the 2026-08-28 demotion still standing; 27-day carry-forward at 2026-09-07 fetch — 25 fetches silent — carries forward unchanged at the 2026-09-07 fetch, the 2026-08-28 demotion still standing; 28-day carry-forward at 2026-09-08 fetch — 26 fetches silent — carries forward unchanged at the 2026-09-08 fetch, the 2026-08-28 demotion still standing; 29-day carry-forward at 2026-09-09 fetch — 27 fetches silent — carries forward unchanged at the 2026-09-09 fetch, the 2026-08-28 demotion still standing; 30-day carry-forward at 2026-09-11 fetch — 28 fetches silent — carries forward unchanged at the 2026-09-11 fetch, the 2026-08-28 demotion still standing; 31-day carry-forward at 2026-09-12 fetch — 29 fetches silent — carries forward unchanged at the 2026-09-12 fetch; 32-day carry-forward at 2026-09-13 fetch — 30 fetches silent — carries forward unchanged at the 2026-09-13 fetch, the 2026-08-28 demotion still standing; entry is a stale carry-forward note; 35-day carry-forward at the 2026-09-16T18:18Z fetch — 33 fetches silent — carries forward unchanged at the 2026-09-14 + 2026-09-15 + 2026-09-16 fetches, the 2026-08-28 demotion still standing; entry is a stale carry-forward note; 38-day carry-forward at the 2026-09-19T18:04Z fetch — 36 fetches silent — carries forward unchanged at the 2026-09-17 + 2026-09-18 + 2026-09-19 fetches, the 2026-08-28 demotion still standing; entry is a stale carry-forward note; 39-day carry-forward at the 2026-09-20T18:07Z fetch — 37 fetches silent — carries forward unchanged at the 2026-09-20 fetch, the 2026-08-28 demotion still standing; entry is a stale carry-forward note; 40-day carry-forward at the 2026-09-21T18:17Z fetch — 38 fetches silent — carries forward unchanged at the 2026-09-21 fetch, the 2026-08-28 demotion still standing; entry is a stale carry-forward note; 41-day carry-forward at the 2026-09-22T18:08Z fetch — 39 fetches silent — carries forward unchanged at the 2026-09-22 fetch, the 2026-08-28 demotion still standing; entry is a stale carry-forward note; 42-day carry-forward at the 2026-09-23T18:10Z fetch — 40 fetches silent — carries forward unchanged at the 2026-09-23 fetch, the 2026-08-28 demotion still standing; entry is a stale carry-forward note; 43-day carry-forward at the 2026-09-24T18:07Z fetch — 41 fetches silent — carries forward unchanged at the 2026-09-24 fetch, the 2026-08-28 demotion still standing; entry is a stale carry-forward note; 44-day carry-forward at the 2026-09-25T18:17Z fetch — 42 fetches silent — carries forward unchanged at the 2026-09-25 fetch, the 2026-08-28 demotion still standing; entry is a stale carry-forward note; 45-day carry-forward at the 2026-09-26T18:09Z fetch — 43 fetches silent — carries forward unchanged at the 2026-09-26 fetch, the 2026-08-28 demotion still standing; entry is a stale carry-forward note; 46-day carry-forward at the 2026-09-27T18:19Z fetch — 45 fetches silent — carries forward unchanged at the 2026-09-27 fetch, the 2026-08-28 demotion still standing; entry is a stale carry-forward note; 47-day carry-forward at the 2026-09-28T18:09Z fetch — 46 fetches silent — carries forward unchanged at the 2026-09-28 fetch, the 2026-08-28 demotion still standing; entry is a stale carry-forward note; 48-day carry-forward at the 2026-09-29T18:14Z fetch — 47 fetches silent — carries forward unchanged at the 2026-09-29 fetch, the 2026-08-28 demotion still standing; entry is a stale carry-forward note; highest carry-forward duration of the 2026-08-07 streak) |
Templates/ |
1 | 类器官IRB申请清单.md v1.0 (2026-08-16, derived from Guo 2026 ethics deep-read, untracked; first customer-facing template produced from a single deep-read; 5-day carry-forward at 2026-08-21 fetch — was 4-day at 2026-08-20; 6-day carry-forward at 2026-08-22 fetch; 7-day carry-forward at 2026-08-23 fetch; 8-day carry-forward at 2026-08-24 fetch; 9-day carry-forward at 2026-08-25 fetch; 10-day carry-forward at 2026-08-26 fetch; 11-day carry-forward at 2026-08-27 fetch — approaching confirmed one-off interpretation alongside the Review/ entry; 12-day carry-forward at 2026-08-28 fetch — 11 fetches silent — now confirmed one-off alongside the Review/ + CelVivo-commercial/ entries at the 2026-08-28 fetch; 13-day carry-forward at 2026-08-29 fetch — 12 fetches silent — carries forward unchanged at the 2026-08-29 fetch, the 2026-08-28 confirmation still standing; 14-day carry-forward at 2026-08-30 fetch — 13 fetches silent — carries forward unchanged at the 2026-08-30 fetch, the 2026-08-28 confirmation still standing; 15-day carry-forward at 2026-08-31 fetch — 14 fetches silent — carries forward unchanged at the 2026-08-31 fetch, the 2026-08-28 confirmation still standing; 16-day carry-forward at 2026-09-01 fetch — 15 fetches silent — carries forward unchanged at the 2026-09-01 fetch, the 2026-08-28 confirmation still standing; 17-day carry-forward at 2026-09-02 fetch — 16 fetches silent — carries forward unchanged at the 2026-09-02 fetch, the 2026-08-28 confirmation still standing; 18-day carry-forward at 2026-09-03 fetch — 17 fetches silent — carries forward unchanged at the 2026-09-03 fetch, the 2026-08-28 confirmation still standing; 19-day carry-forward at 2026-09-04 fetch — 18 fetches silent — carries forward unchanged at the 2026-09-04 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 20-day carry-forward at 2026-09-05 fetch — 19 fetches silent — carries forward unchanged at the 2026-09-05 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 21-day carry-forward at 2026-09-06 fetch — 20 fetches silent — carries forward unchanged at the 2026-09-06 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 22-day carry-forward at 2026-09-07 fetch — 21 fetches silent — carries forward unchanged at the 2026-09-07 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 23-day carry-forward at 2026-09-08 fetch — 22 fetches silent — carries forward unchanged at the 2026-09-08 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 24-day carry-forward at 2026-09-09 fetch — 23 fetches silent — carries forward unchanged at the 2026-09-09 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 25-day carry-forward at 2026-09-11 fetch — 24 fetches silent — carries forward unchanged at the 2026-09-11 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 30-day carry-forward at the 2026-09-16T18:18Z fetch — 30 fetches silent — carries forward unchanged at the 2026-09-12 + 2026-09-13 + 2026-09-14 + 2026-09-15 + 2026-09-16 fetches, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 33-day carry-forward at the 2026-09-19T18:04Z fetch — 33 fetches silent — carries forward unchanged at the 2026-09-17 + 2026-09-18 + 2026-09-19 fetches, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 34-day carry-forward at the 2026-09-20T18:07Z fetch — 34 fetches silent — carries forward unchanged at the 2026-09-20 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 35-day carry-forward at the 2026-09-21T18:17Z fetch — 35 fetches silent — carries forward unchanged at the 2026-09-21 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 36-day carry-forward at the 2026-09-22T18:08Z fetch — 36 fetches silent — carries forward unchanged at the 2026-09-22 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 37-day carry-forward at the 2026-09-23T18:10Z fetch — 37 fetches silent — carries forward unchanged at the 2026-09-23 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 38-day carry-forward at the 2026-09-24T18:07Z fetch — 38 fetches silent — carries forward unchanged at the 2026-09-24 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 39-day carry-forward at the 2026-09-25T18:17Z fetch — 39 fetches silent — carries forward unchanged at the 2026-09-25 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 40-day carry-forward at the 2026-09-26T18:09Z fetch — 40 fetches silent — carries forward unchanged at the 2026-09-26 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 41-day carry-forward at the 2026-09-27T18:19Z fetch — 42 fetches silent — carries forward unchanged at the 2026-09-27 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 42-day carry-forward at the 2026-09-28T18:09Z fetch — 43 fetches silent — carries forward unchanged at the 2026-09-28 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 43-day carry-forward at the 2026-09-29T18:14Z fetch — 44 fetches silent — carries forward unchanged at the 2026-09-29 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; highest carry-forward duration of the 2026-08-07 streak) |
CelVivo-commercial/ |
1 | 1331651_20260630_131201.pdf (2026-06-30 quote PDF migrated into new folder 2026-08-17, untracked; 5-day carry-forward at 2026-08-21 fetch — was 4-day at 2026-08-20; 6-day carry-forward at 2026-08-22 fetch; 7-day carry-forward at 2026-08-23 fetch; 8-day carry-forward at 2026-08-24 fetch; 9-day carry-forward at 2026-08-25 fetch; 10-day carry-forward at 2026-08-26 fetch; 11-day carry-forward at 2026-08-27 fetch — approaching confirmed one-off interpretation alongside the Review/ + Templates/ entries; 12-day carry-forward at 2026-08-28 fetch — 11 fetches silent — now confirmed one-off alongside the Review/ + Templates/ entries at the 2026-08-28 fetch; 13-day carry-forward at 2026-08-29 fetch — 12 fetches silent — carries forward unchanged at the 2026-08-29 fetch, the 2026-08-28 confirmation still standing; 14-day carry-forward at 2026-08-30 fetch — 13 fetches silent — carries forward unchanged at the 2026-08-30 fetch, the 2026-08-28 confirmation still standing; 15-day carry-forward at 2026-08-31 fetch — 14 fetches silent — carries forward unchanged at the 2026-08-31 fetch, the 2026-08-28 confirmation still standing; 16-day carry-forward at 2026-09-01 fetch — 15 fetches silent — carries forward unchanged at the 2026-09-01 fetch, the 2026-08-28 confirmation still standing; 17-day carry-forward at 2026-09-02 fetch — 16 fetches silent — carries forward unchanged at the 2026-09-02 fetch, the 2026-08-28 confirmation still standing; 18-day carry-forward at 2026-09-03 fetch — 17 fetches silent — carries forward unchanged at the 2026-09-03 fetch, the 2026-08-28 confirmation still standing; 19-day carry-forward at 2026-09-04 fetch — 18 fetches silent — carries forward unchanged at the 2026-09-04 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 20-day carry-forward at 2026-09-05 fetch — 19 fetches silent — carries forward unchanged at the 2026-09-05 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 21-day carry-forward at 2026-09-06 fetch — 20 fetches silent — carries forward unchanged at the 2026-09-06 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 22-day carry-forward at 2026-09-07 fetch — 21 fetches silent — carries forward unchanged at the 2026-09-07 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 23-day carry-forward at 2026-09-08 fetch — 22 fetches silent — carries forward unchanged at the 2026-09-08 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 24-day carry-forward at 2026-09-09 fetch — 23 fetches silent — carries forward unchanged at the 2026-09-09 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 25-day carry-forward at 2026-09-11 fetch — 24 fetches silent — carries forward unchanged at the 2026-09-11 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 26-day carry-forward at 2026-09-12 fetch — 25 fetches silent — carries forward unchanged at the 2026-09-12 fetch; 27-day carry-forward at 2026-09-13 fetch — 26 fetches silent — carries forward unchanged at the 2026-09-13 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 30-day carry-forward at the 2026-09-16T18:18Z fetch — 30 fetches silent — carries forward unchanged at the 2026-09-14 + 2026-09-15 + 2026-09-16 fetches, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 33-day carry-forward at the 2026-09-19T18:04Z fetch — 33 fetches silent — carries forward unchanged at the 2026-09-17 + 2026-09-18 + 2026-09-19 fetches, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 34-day carry-forward at the 2026-09-20T18:07Z fetch — 34 fetches silent — carries forward unchanged at the 2026-09-20 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 35-day carry-forward at the 2026-09-21T18:17Z fetch — 35 fetches silent — carries forward unchanged at the 2026-09-21 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 36-day carry-forward at the 2026-09-22T18:08Z fetch — 36 fetches silent — carries forward unchanged at the 2026-09-22 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 37-day carry-forward at the 2026-09-23T18:10Z fetch — 37 fetches silent — carries forward unchanged at the 2026-09-23 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 38-day carry-forward at the 2026-09-24T18:07Z fetch — 38 fetches silent — carries forward unchanged at the 2026-09-24 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 39-day carry-forward at the 2026-09-25T18:17Z fetch — 39 fetches silent — carries forward unchanged at the 2026-09-25 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 40-day carry-forward at the 2026-09-26T18:09Z fetch — 40 fetches silent — carries forward unchanged at the 2026-09-26 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 41-day carry-forward at the 2026-09-27T18:19Z fetch — 42 fetches silent — carries forward unchanged at the 2026-09-27 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 42-day carry-forward at the 2026-09-28T18:09Z fetch — 43 fetches silent — carries forward unchanged at the 2026-09-28 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; 43-day carry-forward at the 2026-09-29T18:14Z fetch — 44 fetches silent — carries forward unchanged at the 2026-09-29 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; highest carry-forward duration of the 2026-08-07 streak) |
Total ≈ 1,211 deep-read notes on main (+5 new LDR files from the 2026-08-31 CelVivo-cluster on top of +4 from the 2026-08-24/25 cluster + +5 from the 2026-08-23/24 single-shot LDR burst + +2 from the 2026-08-16 Quintard 2024 + Guo 2026 clusters; the 5th 2026-08-25 commit 9aa2af4c is an in-place M touch on Tevonian + Yang files, not a new file). The 4 vendor subfolders (Celvivo / 3Brain / Cellink / Organoid) cover the canonical product KB per the wiki goal focus areas. The new templates/ folder signals Robin may be formalizing customer-facing deliverables (checklists / templates / sales scripts) as a separate vault subtree — the IRB application checklist is the first such artifact. The 2026-08-31 cluster creates the NEW CelVivo/ (capital-V) parallel subfolder — Robin's first parallel-naming deep-read subfolder convention.
Literature deep-read (LDR) pipeline
The 4-27 SOP (referenced from /sources/ldr-report-template.md and /sources/2026-07-27-4-27-sop-vs-implementation.md) is the canonical research workflow Robin uses to convert a vendor-paper PDF into a publishable, indexed, cross-system deep read.
stateDiagram-v2
[*] --> PubmedVerify: Id / DOI / PMID / PDF
PubmedVerify --> PDFPull: PubMed eSummary 验真
PDFPull --> ImgExtract: ragflow_direct_download.py / direct path
ImgExtract --> VisionReview: PyMuPDF xref dedup + 30KB + p1 logo
VisionReview --> ReportWrite: Ollama qwen2.5vl:7b (降级 if 服务宕)
ReportWrite --> SeaFileUpload: 5 段模板 (做了什么 / 3 发现 / 4 维对接 / 局限 / 转发语)
SeaFileUpload --> WikiPublish: PDF + 3 真图 → ?dl=1
WikiPublish --> NocoDB: GraphQL 5-orderBy union
NocoDB --> Commit: NocoDB v1 + JSON body (PATCH preferred)
Commit --> [*]: OpenWiki git commit + Gitea push
note right of VisionReview
2026-07-17 起 Ollama 服务宕
视觉审核降级 → 人工肉眼
end note
note right of NocoDB
Cellink 库 "已精读" SingleSelect options=[]
PATCH 失败, 在精读摘要里写
end note
The state diagram shows the canonical LDR pipeline: PDF → images → report → SeaFile → Wiki.js → NocoDB → commit. Two known operational degradations are called out: the Ollama visual-review step falls back to human review since 2026-07-17 (see /themes/04-local-llm.md), and the Cellink library 已精读 SingleSelect is a NocoDB bug that blocks PATCH (workaround documented in the SOP-vs-implementation file).
LDR SOP — 8 铁律 + 3 trigger modes + 5-section report
From /sources/ldr-report-template.md (Robin 7-27 实战版):
| 铁律 | 出处 | 实操 |
|---|---|---|
1. PDF 全文必传 (SeaFile 永久链接, ?dl=1 后缀) |
7-27 教训 | upload.py 上传 PDF, ?dl=1 写 link |
| 2. PyMuPDF xref 去重 + 30KB 过滤 + p1 logo 剔除 | 7-27 教训 (Tasevska p1 logo) | extract_image(xref) per page, MD5 dedup |
| 3. 9 项强制 + 创新点/局限性/学术启示 3 段 | 7-27 教训 (2 篇缺 3 段) | 模板 §3 |
4. SeaFile URL hostname fb.biokingdom.top |
7-27 教训 (5 URL 错) | 验证 share-link 真能开 |
| 5. NocoDB v1 + JSON body (范本 v2 失败 3 次) | 7-27 Tasevska 入库 | POST /api/v1/db/data/wzg1wtad/p2z4g0s687axyvu/{table_id} |
6. 3 张真图 ![]() (SeaFile URL), 不只文字图说啥 |
7-27 教训 | markdown image syntax (alt text + parenthesized URL) |
7. 报告路径 journal-year-topic (4-27 SOP 范本) |
7-27 教训 | ejps-2025-hctz-sse-3d-printing 风格 |
| 8. 精简 4 步 vs 完整 8 步按 Robin 信号自动判断 | 7-27 实战 | 模板 §2 |
3 trigger modes:
| Robin says | I take | 耗时 |
|---|---|---|
| "精读吧" (any PDF, no publish intent) | 精简 4 步 (PDF → PyMuPDF → 写报告 → Obsidian) | 20-30 min |
| "A" / "发 wikijs" / "SeaFile 永久" / "入库" / "NocoDB" | 完整 8 步 (精简 4 步 + Ollama 视觉 + SeaFile + Wiki.js + NocoDB) | 45-60 min |
| "X 还是 Y" / "你定" / "继续下一篇" | 自动 | — |
5-section report template (800–1500 chars): 1. 做了什么 / 2. 3 关键发现 (每发现 3 段式表) / 3. 4 维产品对接 (CelVivo / 3Brain / Cellink / Femtobiomed) / 4. 局限 / 5. 转发语 + 落款 + PDF.
Worked examples (canonical deep reads)
| Deep read | Vendor | Path | Synthesized at |
|---|---|---|---|
| Bosnjakovic 2025 bioRxiv | CelVivo | 04-Literature/Deep-Reads/Celvivo/Bosnjakovic_2025_PAH_3D_spheroid_CelVivo_ClinoStar_2026-07-27.md |
/sources/literature-cel-bosnjakovic-2025-pah-deepread.md |
| Raji 2026 Mol Psychiatry | 3Brain | 04-Literature/Deep-Reads/3Brain/Raji_2026_hMOs_dopaminergic_3Brain_MEA_2026-07-27.md |
/sources/literature-raji-2026-deepread.md |
| Tasevska 2025 EJPS | Cellink | 04-Literature/Deep-Reads/Cellink/Tasevska_2025_HCTZ_3D_printed_extended_release_2026-07-27.md |
/sources/literature-tasevska-2025-deepread.md |
| CelVivo 2026 brain organoid whitepaper (16 pp) | CelVivo | under 04-Literature/Deep-Reads/Celvivo/ |
/sources/literature-celvivo-brain-whitepaper-2026.md |
| Hodge 2025 RegenMed | Ronawk Bio-Block (KB 0 命中) | 04-Literature/Deep-Reads/RegenMed/2026-07-28_Hodge_2025_RegenMed_MSC_3D_Bio-Block.md |
(not yet synthesized to /sources/) |
| Lee 2025 Front Vet Sci | (no vendor) | 04-Literature/Deep-Reads/Other/2026-07-28_Lee_2025_FrontVetSci_canine_MSC_3D_spheroid.md |
(not yet synthesized) |
| Parate 2020 SCRT | (no vendor) | 04-Literature/Deep-Reads/Other/2026-07-28_Parate_2020_SCRT_PEMF_MSC_paracrine_cartilage.md |
(not yet synthesized) |
| Sharma 2026 Cell Stem Cell (2026-08-08 flywheel-sync) | 3Brain + CelVivo adjacent | /home/ldw/workspace/retinal_organoid_deep_read_2026-08-07.md |
/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md |
| Miao 2025 Cell v2 (2026-08-08 flywheel-sync) | CelVivo (ClinoStar rating 5) | /home/ldw/workspace/Miao2025_Cell_v2.md |
/sources/literature-miao-2025-cell-vascularization-v2-deepread.md |
| Liu 2026 Nat Biomed Eng (2026-08-08 flywheel-sync) | 3Brain (HD-MEA rating 5) + Cellink (microlattice rating 5) | /home/ldw/workspace/Liu2026_NBME_shape_conformal_organoid.md |
/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md |
| Quintard 2024 Nat Commun (2026-08-16 vault LDR cluster) | CelVivo (ClinoStar rating 3 upstream) + Mimetas OrganoPlate (rating 4 direct) + Emulate Organ-Chip (rating 3) | obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md |
(not yet synthesized to /sources/) |
| Guo 2026 Front Cell Dev Biol (2026-08-16 vault LDR cluster) | CelVivo (ClinoStar rating 4 clinical-translation IRB) + Mimetas OrganoPlate (rating 4 co-culture ethics) + Emulate Organ-Chip (rating 3) | obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md |
(not yet synthesized to /sources/; derived customer-facing template at templates/类器官IRB申请清单.md v1.0) |
Recent 30-day research output (mtime 2026-06-16 → 2026-08-12)
From /sources/literature.md last sync, broken out by vendor and date:
| Date | DOI / slug | Vendor | Topic |
|---|---|---|---|
| 2026-08-16 | Quintard 2024 Nat Commun + Guo 2026 Front Cell Dev Biol 7-commit LDR cluster (commits 0fc8db24 + 290e9635 + 24c713de + 4073abf4 Quintard + 2e6f5989 + 00f824f2 + a4fa5a32 Guo) |
CelVivo adjacent + Mimetas OrganoPlate ⭐⭐⭐⭐ + Emulate Organ-Chip ⭐⭐⭐ (Quintard) / CelVivo ClinoStar ⭐⭐⭐⭐ + Mimetas OrganoPlate ⭐⭐⭐⭐ + Emulate Organ-Chip ⭐⭐⭐ (Guo) | Quintard C et al. (2024) A microfluidic platform integrating functional vascularized organoids-on-chip (Nat Commun DOI 10.1038/s41467-024-45710-4, Wiki ID 1719/1720/1722, NocoDB Id 3297; 10 通道并行微流控 + hiPSC-BVO 30 天功能性灌注培养 + 跨类器官验证 [间充质球体 / BVO / 胰岛球体 / 肺类器官]; 血管层级化 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管, 壁剪切 27-2000 s⁻¹, 完美匹配人体毛细血管生理范围 50-1900 s⁻¹) + Guo Z & Zhang N (2026) Ethical review key considerations for organoid applications in biomedical research—a systematic review (Front Cell Dev Biol DOI 10.3389/fcell.2026.1721946, Wiki ID 1724, NocoDB Id 3298; 嘉兴市第一医院 + 嘉兴大学医学院视角; 类器官研究 IRB / 伦理审查 7 大强制要点系统综述 [样本来源/知情同意/数据隐私/共培养主体性/3R 动物福利/跨境监管/长期保存与终止使用] + 中国《人类遗传资源管理条例》+ 国际 ISSCR/GDPR/HIPAA 多国对照表). Robin translated Guo 2026 into a customer-facing IRB application checklist template (templates/类器官IRB申请清单.md v1.0 180 lines) — first customer-facing template produced from a single deep-read. |
| 2026-08-25 | SECOND consecutive single-day 5-paper LDR burst (commits 089177a7 Tevonian + 583859a8 Yang + 9aa2af4c vendor-mapping retrofit + 5907cdfc Shen + 9d4767c7 Zhai) |
5-vendor product mapping retrofit on Tevonian + Yang (CelVivo ClinoStar/ClinoReactor + Cellink BIO X + Mimetas OrganoPlate + 3Brain HD-MEA + FemtoBiomed CellShot) | Tevonian 2026 Nat Commun vascularized liver MPS (PMID 41634021, Wiki.js 1749; PDMS+fibrin+原代肝+HUVEC vascularized liver MPS, 14天 IR modeling, 单核细胞 infiltration enhancement; first file in new Vascularized-Organoids/ subfolder) + Yang 2026 Stem Cell Res Ther cardiac organoid review (PMID 41963991, Wiki.js 1750; 复旦 + InnoStar comprehensive review of hPSC cardiac organoid generation methods (FGF/PI3K/Wnt/BMP/Activin/RA 五大信号通路) + maturation protocols + disease modeling + regenerative medicine; first file in new Cardiac-Organoids/ subfolder — first new subfolder explicitly for an application-domain cluster) + post-publish vendor-mapping retrofit commit 9aa2af4c on Tevonian + Yang (adds 5-vendor mapping table + 净化 Robin mentions; first post-publish vendor-mapping retrofit step in Robin's LDR pipeline, iterates the 8-step SOP to a 9-step SOP) + Shen 2026 Chin Med J vascularized organoids review (PMID 42268296, Wiki.js 1751; 华西医院 Chinese-language peer-reviewed systematic review of vascularized organoids 4 大策略 (共培养 + 转录因子诱导 + 微流控 + 生物材料支架) + 12 维对比 + 三大未来方向; second file in Vascularized-Organoids/ subfolder) + Zhai 2026 Sci Adv 3D skin pemphigus (PMID 41512055, Wiki.js 1752; 3D 打印 + 自组织 multilayer vascularized skin model for 天疱疮 autoimmune disease modeling + EGFR-targeted therapy + ML-assisted drug screening; first file in new Skin-Organoids/ subfolder — net-new application domain autoimmune dermatology + 3D skin). 3 NEW 04-Literature/Deep-Reads/ subfolders created in a single day: Vascularized-Organoids/ + Cardiac-Organoids/ + Skin-Organoids/ (Robin expands the deep-read folder taxonomy from ~19 → ~22, returning to per-vendor / per-application-domain subfolder discipline after the 2026-08-23/24 root-level non-standard pattern). Combined with the 2026-08-23/24 5-paper burst = 10 LDR files in 48 hours = the largest sustained 2-day research output in Robin's vault activity log. |
| 2026-08-31 | THIRD consecutive single-day 5-paper LDR burst (commits eb24ab72 Stewart + 030f31ed Aiello + fad7e21e Nguyen + 4fca0123 Miao + 391e4713 Yan) — all 5 exclusively CelVivo-anchored (QIMR Berghofer Suhrbier/Rawle viral-neurotropism line + CelVivo ApS co-authored reproducibility + vascularized lung/gut) |
CelVivo ClinoStar / ClinoReactor (direct platform validation across 4 brain organoid infectious-disease papers + 1 vascularized lung/gut paper; 1 paper — Aiello 2025 — has CelVivo ApS as a co-author affiliation, validating the ClinoStar/ClinoReactor platform as a reproducibility-benchmarking standard) | Stewart 2023 Front Microbiol SARS-CoV-2 omicron BA.5/XBB neurotropic brain organoids (DOI 10.3389/fmicb.2023.1320856; QIMR Berghofer Medical Research Institute + University of Queensland; K18-hACE2 mice + human brain organoids; MA1 infection cell count higher; first file in new CelVivo/ capital-V subfolder) + Aiello 2025 EMBO reports reproducible brain organoids (DOI 10.1038/s44319-025-00619-x; 洛桑大学 + 罗马 Tor Vergata 大学 + 西北大学 (南非) + CelVivo ApS (丹麦) co-author; controlled fluid dynamics brain organoid reproducibility; CV <15% multi-batch + multi-cell-line) + Nguyen 2024 npj Viruses JEV G4 2022 Australia brain organoids (DOI 10.1038/s44298-024-00025-5; QIMR Berghofer + INRAE; JEV genotype 4 isolate characterization) + Miao 2025 Cell vascularized lung/gut organoids (DOI 10.1016/j.cell.2025.05.041; co-differentiation mesoderm+endoderm for organotypic vascularization; companion to the 2026-08-08 flywheel-sync Miao 2025 v2 deep-read) + Yan 2024 Cell Reports TMEM106B SARS-CoV-2 ACE2-independent brain organoids (DOI 10.1016/j.celrep.2024.114921; QIMR Berghofer; CRISPR 筛选鉴定 TMEM106B/硫酸乙酰肝素/内吞介导 ACE2 非依赖进入; 人源皮层脑类器官 CelVivo ClinoStar; MA1 神经毒力更强 in vitro but in vivo not consistent). 5 papers all single-shot LDR entries (no v2/v3 SOP rewrite cycles this cluster); cluster does NOT receive the 9aa2af4c post-publish vendor-mapping retrofit commit (no companion retrofit this cluster, unlike the 2026-08-24/25 cluster which had 9aa2af4c as the 3rd of 5 commits). 1 NEW 04-Literature/Deep-Reads/ subfolder created: CelVivo/ (capital-V, parallel to existing lowercase Celvivo/ subfolder) at obsidian-vault/04-Literature/Deep-Reads/CelVivo/ — Robin's first parallel-naming deep-read subfolder convention (subfolder taxonomy from ~22 → ~23 in 8 calendar days). Combined with 2026-08-23/24 + 2026-08-24/25 = 15 LDR files in 8 calendar days = the largest sustained 8-day research output in Robin's vault activity log. Ends the 5-day vault silence streak from the 2026-08-24/25 burst. |
| 2026-08-24 | First 5-paper LDR burst in 24-hour window (commits ad4abcde Ajongbolo + 5f02489a Kim + 40b357b8 Tian + f2118a62 Aiello + fb017e4f CelVivo App Note) |
CelVivo-aligned (3) + 3Brain-adjacent (1) + cardiac-epicardium (1) | Ajongbolo 2025 Cells brain organoid review (PMID DOI 10.3390/cells14110842, Wiki.js 1743; canonical brain organoid + assembloid review with 3-tier taxonomy + 4-class characterization methodology) + Kim 2025 Nat Commun EGaIn liquid-metal 3D MEA (DOI 10.1038/s41467-024-55752-3, Wiki.js 1744; 25-310 µm pillar height, 14 µm diameter, magnetically reshapeable; 3Brain HD-MEA adjacent) + Tian 2025 Nat Commun hiPSC epicardium mTOR maturation (DOI 10.1038/s41467-025-60934-8, Wiki.js 1745; Torin1 dual mTORC1/2 inhibition drives mature epicardium via YBX3/MAFF TFs) + Aiello & Bagni 2025 biorxiv Rotating Chamber brain organoid CFD (Wiki.js 1746; COMSOL CFD < 20 mPa cavity shear stress, cross-organoid-line morphological CV < 15%) + CelVivo App Note 2026 shear stress ClinoStar vs orbital shaker (Wiki.js 1747; head-to-head comparison across HepG2/C3A + Caco-2 + brain organoid — first vendor App Note deep-read). All 5 files landed at 04-Literature/Deep-Reads/ root (non-standard pattern vs the prior per-vendor subfolder discipline). Vendor-anchor mapping: 3 CelVivo-aligned (CelVivo App Note + Aiello [ClinoStar-adjacent] + Ajongbolo mentions ClinoStar) + 1 3Brain-adjacent (Kim EGaIn 3D MEA — 3rd next-gen HD-MEA approach alongside Liu 2026 + 3Brain Accura-3D) + 1 cardiac epicardium (Tian mTOR, no vendor callouts). Largest single-day LDR burst since the 2026-07-29 Parate / Lee / Hodge cluster. |
| 2026-08-12 | Liang 2026 liver organoid fibrosis platform 4-commit LDR cycle (commits e542c977 + 8699a154 + aacba7aa + 297f106d) |
CelVivo (ClinoStar rating 5 + ClinoReactor rating 5) | Liang Y et al. (2026) A robust mouse liver organoid platform enables sustained multicellular maturation and fibrosis modeling from a single tissue sample (Sci Rep DOI 10.1038/s41598-026-42990-2, PMID 41857098; Wiki.js Id 1716, NocoDB Id 770; 3 轨道 Hep-Orgs + Cho-Orgs + HSC 同步分离; DAPT+Dex P1-P10 长程稳定成熟 [ALB/PAS/LDL/CYP 跨代保持]; TGFβ 激活 qHSC → aHSC [Acta2/Col1a1 上调]; aHSC 共培养诱导 Hep-Orgs EMT [Snail/Twist/Vimentin↑; ALB/CK8↓; Lgr5/EpCAM↓; Ki67↓] = 体外肝纤维化模型) — page 946 9 项 SOP 重写版 + page 934 修齐 标杆; 7/7 Ollama qwen2.5vl 视觉审核通过; SeaFile 7/7 公网 200 验真. First paper whose related: field already names [[MOC-类器官与3D培养]] (the 2026-08-10 first MOC) on the day of publication. |
| 2026-08-10 | Phase A metadata batch + first MOC (commits d97b39ed + 6b717aef + 3b929c2f) |
(process discipline) | 6 deep-reads received the 6-field frontmatter (doi/journal/year/volume/pages/authors/pmid); first MOC MOC-类器官与3D培养.md (95 lines, 沙牛《AI 时代的 Obsidian 公开课》课时 1 pattern) created at 04-Literature/Deep-Reads/MOCs/; 7 image alt descriptions added on wang2024-org-on-chip.md. No new external evidence. |
| 2026-08-09 | 10.7150/thno.90492 (Wang 2024) |
(4 类共性硬件 — Organoid-on-Chip 综述) | Wang H et al. (2024) Human organoids-on-chips for biomedical research and applications (Theranostics 14(2):788-818, PMID 38169573; 7 图覆盖 7 大主题板块) — Wiki.js ID 1700 (v2 - grp:3 ghost page 累加) |
| 2026-08-08 | 10.3390/cells15110963 (Fernandez Vallone 2026) |
(NAMs adjacent, hiPSC brain organoid) | THSDC chemical evaluation platform using hiPSC brain organoids (Cells, v2 5 张真图 + 双 H1; Wiki.js Id 1698) |
| 2026-08-08 | 10.3389/fbioe.2026.1854988 (Rosero 2026) |
CelVivo + Cellink + FemtoBiomed adjacent | Microbioreactor design Mini Review (Front Bioeng Biotechnol; 6× productivity vs T-flask; 4 applications: CAR-T / mAb / iPSC / organoid) |
| 2026-08-08 | 10.1038/s41551-026-01620-y (Liu 2026) |
3Brain (HD-MEA rating 5) + Cellink (microlattice rating 5) | Shape-conformal porous framework for full-coverage neural organoid e-phys — Rogers Lab, Nat Biomed Eng |
| 2026-08-08 | 10.1016/j.cell.2025.05.041 (Miao 2025 v2) |
CelVivo (ClinoStar rating 5) | Co-development mesoderm+endoderm for vascularized lung/gut organoids (Cell v2) |
| 2026-08-08 | 10.1016/j.stem.2025.12.013 (Sharma 2026) |
3Brain (HD-MEA rating 4) + CelVivo (ClinoStar rating 3) | Vascularized retinal organoid RGC survival (Cell Stem Cell) |
| 2026-08-06 | 10.1038/s41467-024-44732-2 (Parfitt 2024) |
CelVivo + 3Brain adjacent | DJ1 LOF midbrain organoid PD model — α-syn via astrocyte lysosomal degradation (Nat Commun, untracked) |
| 2026-07-29 | Organoids for disease modeling and treatment 2026 综述 (PMID 41545895, PMC12828948) | review | Exp Hematol Oncol 2026 — 190 项临床试验 + 4 大瓶颈 |
| 2026-07-28 | 10.1080_17460751.2025.2572177 (Hodge 2025) |
Ronawk Bio-Block | MSC longevity 4-week comparison |
| 2026-07-28 | 10.3389/fvets.2025.1500267 (Lee 2025) |
(no vendor) | canine adipose MSC 3D spheroid |
| 2026-07-28 | 10.1186_s13287-018-1085-9 (Komatsu 2018) |
CelVivo + Cellink | Type I collagen + YAP/TAZ |
| 2026-07-28 | 10.1186_s13287-020-1566-5 (Parate 2020) |
(no vendor) | PEMF potentiate MSC paracrine cartilage |
| 2026-07-27 | Raji_2026_hMOs |
3Brain | hMOs dopaminergic + HD-MEA |
| 2026-07-27 | Tasevska_2025_HCTZ |
Cellink | SSE-printed HCTZ extended-release |
| 2026-07-17 | 260528_CS_vs_OS appnote |
CelVivo | ClinoStar vs Orbital Shaker shear stress |
| 2026-07-17 | 111_Planimetry appnote |
CelVivo | FIJI planimetry on ClinoReactor |
| 2026-07-05 | 10.1002_btpr.2528 |
CelVivo | Spheroid dissociation device |
| 2026-06-25 | 10.1016_j.stemcr.2025.102646 |
CelVivo | High-throughput microfluidic organoid-on-a-chip |
| 2026-06-24 | 10.1021_acsomega.5c02682 |
3Brain | rotating human melanoma cell culture |
| 2026-06-24 | 10.1016_j.xpro.2025.103923 |
CelVivo | Lung Tumoroids protocol |
| 2026-06-23 | 10.1002_jbm4.10792 |
CelVivo | microfluidic organoid-on-a-chip (v2-munir2023) |
| 2026-06-23 | 10.3390_cells11203216 |
CelVivo | NAFLD mapping proteome/lipidome |
By vendor (30-day mtime):
| Vendor | Most recent | 2026-08-08 / 2026-08-10 / 2026-08-12 / 2026-08-16 additions |
|---|---|---|
| CelVivo | 2026-08-12 (Liang 2026 — ClinoStar rating 5 + ClinoReactor rating 5) | +Liang 2026 (P1-P10 长程成熟 + 单组织 3 轨道分通道灌流 + TGFβ 时间程序精确切换 — liver organoid fibrosis platform), +Miao 2025 v2 (ClinoStar co-differentiation), +Sharma 2026 (ClinoStar rating 3 adjacent), +Liu 2026 (ClinoStar rating 4 adjacent), +Quintard 2024 (CelVivo ClinoStar rating 3 — upstream workflow step: BVO day 0-15 needs rotating-wall suspension culture), +Guo 2026 (CelVivo ClinoStar rating 4 — clinical-translation IRB compliance for 三甲医院 客户) |
| 3Brain | 2026-08-08 (Liu 2026 — HD-MEA rating 5) | +Liu 2026 (shape-conformal framework, next-gen HD-MEA), +Sharma 2026 (HD-MEA rating 4 adjacent), +Shin 2024 (Phase A frontmatter hygiene on existing note), −3Brain reference removed from Quintard 2024 -v4 (per commit 4073abf4 — "精读 Quintard 2024 -v4 (转发语标题/落款加粗/删3Brain)" was the explicit SOP rule "硬门槛合规修正" cleanup; Quintard is vendor-adjacent CelVivo/Mimetas/Emulate rather than 3Brain territory) |
| Cellink | 2026-07-27 (Tasevska 2025) | +Liu 2026 (microlattice fabrication rating 5 adjacent), +Quintard 2024 (microfluidic organ-on-chip adjacent, no direct Cellink rating — but the platform architecture is a candidate cross-sell with Cellink BIO X for vascularized scaffold fabrication) |
| Adjacent (no vendor) | 2026-08-08 (Sharma 2026 retinal vascularization) | +Sharma 2026 (retinal organoid application domain) |
| (Process discipline) | 2026-08-10 (Phase A batch + first MOC) | +6 deep-reads received 6-field frontmatter; +first MOC MOC-类器官与3D培养.md created; +7 image alt descriptions on Wang 2024 — no new external evidence |
| (Subfolder expansion, uncommitted) | 2026-08-13 (new Review/ subfolder) |
+1 untracked file Review/zhou2023_computer_vision_microfluidics.md (first review-type subfolder — review papers stream separately from original research) |
| (Customer-facing template, uncommitted) | 2026-08-16 (new templates/ subfolder + IRB application checklist v1.0) |
+1 untracked file templates/类器官IRB申请清单.md 180 lines (Guo 2026 ethics deep-read → IRB checklist template; 7 mandatory points + 5 customer Q&A + China vs International flow + 10 attachments + 7 citations; Robin's first customer-facing template produced from a single deep-read; will route into CelVivo industrial-customers program once committed) |
| (Commercial quote PDF, untracked) | 2026-08-17 (new celvivo_commercial/ subfolder) |
+1 untracked file celvivo_commercial/1331651_20260630_131201.pdf (6-30 quote PDF migrated into a new folder; companion to the existing 05-Documents/Products/Celvivo/Industrial-Customers/ commercial-docs subtree) |
The pipeline is vendor-balanced — CelVivo, 3Brain, Cellink each have a recent deep read, and the 2026-08-08 flywheel-sync adds 3 papers spanning all 3 primary vendors + the retinal organoid application domain (Sharma), all 3 rated 4-5 on at least one vendor's product line. The 2026-08-10 cluster is process discipline (Phase A metadata batch + first MOC creation + Wang 2024 alt-description sample), not new external evidence — the 6 deep-reads already existed on main; the 3 commits only normalize their metadata and add a knowledge-graph index layer. The 2026-08-12 cluster adds net-new external evidence: Liang 2026 Sci Rep liver organoid fibrosis platform (4-commit LDR cycle on a single paper, CelVivo ClinoStar ⭐⭐⭐⭐ + ClinoReactor ⭐⭐⭐⭐); this is the first paper on main whose related: field already names [[MOC-类器官与3D培养]] on the day of publication, confirming the MOC pattern is in active use on real deep-reads (vs the prior 2026-08-10 "MOC related: lists future MOCs" framing which was only prospective). The first entry in the new NocoDB table Robin_Picked_Papers is Liu 2026 (created 2026-08-08 per Robin instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage). The first MOC MOC-类器官与3D培养.md is the start of a Map-of-Content layer Robin appears to be building (the MOC's own related: already names [[MOC-3Brain-HD-MEA]] as the next planned MOC). The 2026-08-13 cluster (no vault commits, 1 new untracked file) adds a new Review/ subfolder to the deep-read tree — Robin appears to be expanding the folder taxonomy to separate review-type papers from original-research papers; whether this is a one-off subfolder or the start of a recurring folder pattern is a watchlist item for the next git-repo fetch. The 2026-08-16 cluster (Quintard 2024 + Guo 2026) is the largest single-window vault delta since the 2026-07-28 / 2026-07-29 cluster — 7 new vault commits spanning 2 new paper deep-reads, 2 new untracked working-tree directories, and 1 customer-facing sales-ammunition template derived from a single deep-read. The Quintard 2024 microfluidic / organ-on-chip platform (CelVivo ClinoStar upstream + Mimetas OrganoPlate direct competitor + Emulate Organ-Chip) extends Robin's vendor mapping into the organ-on-chip product lane that his portfolio doesn't currently cover; the Guo 2026 organoid ethics systematic review (7 mandatory points + 5 jurisdiction comparison) introduces the IRB / ethics domain to Robin's deep-read set and spawned templates/类器官IRB申请清单.md (180 lines, Robin's first customer-facing template) as the canonical "Robin 培训客户 IRB 申请" core material. The new templates/ + celvivo_commercial/ directories appear alongside the existing 05-Documents/Products/Celvivo/Industrial-Customers/ commercial-docs subtree — Robin may be formalizing customer-facing deliverables (checklists / templates / sales scripts) as a separate vault subtree. The Review/zhou2023_computer_vision_microfluidics.md carry-forward untracked file is still-uncommitted at this fetch (now 4 days past the 2026-08-13 first observation); the watchlist trigger is if it remains uncommitted at the next fetch.
Sales ammunition pipeline
Robin maintains a working sales library that consumes LDR output and routes into the /sources/sales-ammunition.md page:
- Pricing + SKUs: Demo kit
10005-6lists at €300 (Global Distributor Price, with special discount);10004-12ClinoReactor 12-pack;30003ClinoStar;SP5D-24Wlow-adherence plate. Pricing source:Exhibit 1_Celvivo Price Book 2026_Global_Distributior.xlsx(RAGFlow KB full-text). - 8 ClinoReactor Protocols: 003 (prepare) / 004 (media change) / 006 (gardening) / 009 (plate config) / 010 (ClinoReactor prepare) / 012 (rotation speed — core selling point) / 014 (alginate embed) / 015 (VitroGel embed).
- 5 application notes by organ: HepG2/C3A liver / FTC-133 thyroid / NCI-H69V SCLC / TNBC / ClinoStar vs Orbital Shaker.
- 5 brand / whitepapers: Brochure 2026 update_for print + _online version / Cancer White Paper 2026 / 2026.04.01.715868v1 (biorxiv 2026 preprint) / ijms-24-13506-v2.
- 8 commercial docs: Exhibit 1 Price Book / Exhibit 3 SuperUser certification / Huibai demo discount agreement / 惠百 PO 盖章版 / Celvivo Distribution Agreement 2026 Huibai Bio / 1331651_20260630_131201 (6-30 quote) / Packing Slip Ordre 726_1 / Packing Slip Ordre 726_2.
Cross-link to the canonical synthesis: /sources/sales-ammunition.md.
2026-08-16 addition — templates/类器官IRB申请清单.md v1.0 (180 lines, Robin 8-16 实战沉淀, untracked; derived from Guo 2026 Front Cell Dev Biol IRB / ethics systematic review — Wiki.js ID 1724, NocoDB Id 3298). The IRB application checklist is Robin 第一份 customer-facing template produced from a single deep-read and consists of: (a) 7 强制要点 [样本来源合法性 + 捐赠者知情同意 + 数据隐私与去标识化 + 共培养产物主体性评估 + 动物福利 3R + 跨境监管合规 + 长期保存与终止使用]; (b) 5 customer Q&A [类器官研究是否要 IRB 申请 / 类器官共培养产品怎么申请 IRB / 类器官跨境研究怎么报 / 3R 原则怎么写 / 类器官 + 免疫细胞共培养 = CAR-T 体外培养, 算不算新生物体]; (c) China vs International flow comparison table [中国 2023 新规 vs 美国 Common Rule vs 欧盟 GDPR]; (d) 10 申请附件清单 [IRB 申请表 + 知情同意书 + 研究方案 + DMP + 样本采集机构 IRB 批件 + ...]; (e) 7 引用 [Guo 2026 + ISSCR 2021 + OHRP 2016 + GDPR + 中国 2023 + 中国 2019 + Cambridge 2020]. Vendor relevance: CelVivo ClinoStar ⭐⭐⭐⭐ (the 7 mandatory points directly apply to ClinoStar customer IRB submissions; Robin 推广 ClinoStar 给三甲医院时, 可附带本框架作为增值). Tracks as /commitments.md guo-2026-organoid-irb-checklist-rollout (Owner: me; fold IRB application checklist into CelVivo industrial-customers program + Robin customer-training core material; commit templates/类器官IRB申请清单.md and add a synthesis page at /sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md).
Sales training cluster (working-tree additions)
Per /sources/git-repo.md §"Notable entities", 06-Sales/Content/Training-Materials/ contains the following working-tree additions not yet on main:
CelVivo_销售培训_PPT_v9_给销售看版.pptx(3.9 MB, 06-26 14:13) — latest PPTCelVivo_Robin老师逐字稿_v6_深度版_20260626.md(63 KB, 06-26 13:45) — latest verbatim scriptCelVivo_销售培训_讲义_v2_20260626.md(13 KB, 06-26 12:14) — latest handoutRobin稿生成通字稿family (v3–v6) andCelVivo赋能培训family (v1–v9, depth-flavored edits)销售基础话术包pair
The version progression is 基础 → 5大管线 → 深度版 → 终稿修正 → 销量仅看 — the cluster is iterated in place, not committed. See /sources/vault-mtime-snapshot-2026-07-16.md for the latest mtime census (CelVivo_销售培训_PPT_v9 = 2026-06-26 14:13).
China distributor map (259 dealers across 7 regions — 2026-08-07 baseline)
From /sources/distributors-china-2026.md (Hermes整理, 2026-08-07; replaces 2026-07-24 baseline of 261 dealers):
| Region | 8-07 count | 7-24 count | Δ | Share | Main city |
|---|---|---|---|---|---|
| 华北 | 72 | 74 | -2 | 27.8% | 北京 (54) |
| 华东 | 68 | 68 | 0 | 26.3% | 上海 (53) |
| 华南 | 62 | 62 | 0 | 23.9% | 广州 (44) |
| 山东 | 25 | 25 | 0 | 9.7% | 济南 (22) |
| 湖北 | 19 | 19 | 0 | 7.3% | 武汉 (12) |
| 西北 | 6 | 6 | 0 | 2.3% | 西安 (6) |
| 西南 | 7 | 7 | 0 | 2.7% | 重庆 (3) |
| TOTAL | 259 | 261 | -2 | 100% | — |
Brand keyword map (top 20 by 全国 count): BI 19 / Thermo 19 / Bio-Rad 11 / 赛默飞 8 / 安捷伦 7 / 蔡司 6 / Cytiva 6 / 伯乐 6 / 徕卡 6 / 赛多利斯 5 / Eppendorf 5 / Leica 5 / Beckman 4 / Merck 4 / Waters 4 / Azure 3 / Bruker 3 / Oxford Nanopore 3 / Agilent 3 / Sartorius 3.
8-07 独有产品-代理映射 (from _known_associations.md):
| 产品线 | 关联代理 / 中间方 | 关联客户 / 商机 |
|---|---|---|
| CelVivo (ClinoStar) | 济南成全生物科技 (曹沛起) — 华北 + 山东 跨区重复 | 董慧群 (CelVivo 技术同事) — 8-07 hook 4 候选 |
| FemtoBiomed (CellShot / PROLIVA) | 9X Bio (汇佰生物) — 中间方 (0 hit in 259 dealer 表) | TriArm Therapeutics (翁靖傑 上海 CGT/CAR-T, 128 万 Phase1 / 8-10 至 8-14 现场 demo) |
| 3Brain (HD-MEA) | 0 家代理命中 | 11+ end-customer dossiers (需要补 direct agent or sell direct) |
| Cellink (BIO X) | 0 家代理命中 | (待补) |
Data gap (regional filling rate): 华东 营收 0/68 / 湖北 营收 0/19 / 华南 销售人数 0/62 — needs补 before next field visit. Documented at /sources/distributors-china-2026.md §关键数据缺口.
4-vendor break-out is partially resolved: the 2026-08-07 _known_associations.md index identifies CelVivo → 济南成全 + FemtoBiomed → 9X Bio; 3Brain / Cellink direct agents are still 0 (open-question distributors-3brain-cellink-zero-coverage).
CRM — active distributor profiles
From /sources/agents.md (last sync 2026-07-28; 2026-08-07 _known_associations.md partial resolution):
| 姓名 | 角色 | 代理商品牌 | 主推产品 | 首次记录 | 状态 | Vault 路径 |
|---|---|---|---|---|---|---|
| 董慧群 | 代理商技术同事 | 待补 | CelVivo (ClinoStar / ClinoReactor) | 2026-07-28 | active | 02-Clients/Agents/董慧群.md |
This is the only profile currently in the agents bucket. Robin was told about 董慧群 via WeChat DM on 2026-07-28; her role is to help push CelVivo products at the technical / demo / selection stage. Most fields are 待补 (agency name, region, phone, WeChat, customers, opportunities) — this is the only active open question in /open-questions.md (see agent-dong-huiqun-celvivo).
2026-08-07 partial resolution (Hermes hook 4): 4 个经销商管理 Hook 升级 (02-Clients/Agents/_known_associations.md commit 4b237a82) identifies 济南成全生物科技有限公司 (曹沛起) as the only CelVivo ClinoStar-listed agent in the 259-dealer China map (华北 + 山东 跨区重复登记). Whether 董慧群 is 济南成全的技术同事 or another dealer is still unverified — tracked as commitment dong-huiqun-ji-nan-chengquan-link in /commitments.md. The same hook 4 file maps FemtoBiomed CellShot → 9X Bio (汇佰生物) → TriArm Therapeutics (翁靖傑 上海 CGT/CAR-T, 128 万 Phase1 / 8-10 至 8-14 现场 demo), and 3Brain / Cellink / FemtoBiomed direct agents → 0 in the 259 baseline (open-question distributors-3brain-cellink-zero-coverage).
Privacy rule (Robin 7-28): /sources/agents.md and /sources/distributors-china-2026.md contain only base identity (name / role / vendor / region); sensitive fields (phone / WeChat / email / end-customer list / opportunity value) live only in the private Obsidian vault. The 2026-08-07 _known_associations.md index adds the product-line → agent → end-customer → opportunity mapping chain — but does not break the privacy rule because sensitive fields remain in the private vault files.
End-customer dossier set
11+ dossiers under 03-Resources/End-Customers/ covering 3Brain HD-MEA accounts at: 神经所 (上海), 北京大学, 北京天坛医院, 浙大一附院, 中科院昆明动物所, 西南医科大学, 贵州医科大学, plus TCM accounts at 云南中医药大学 and 天津创新中药. Dossier content lives in the private vault — only the vault paths are surfaced to the wiki. Documented at /sources/git-repo.md §Notable entities.
CelVivo industrial-customers program (China commercial)
A dedicated subfolder under 05-Documents/Products/Celvivo/Industrial-Customers/ holds:
CelVivo_中国工业客户开发研究报告(v1 + v2)客户管线定位_1页图工业客户开发手册-v3
This is a self-contained CelVivo China commercial effort. The latest mtime census (2026-07-16 snapshot) shows CelVivo_中国工业客户开发研究报告_20260626_v2.md as the most-recent file (18 KB, 06-26 11:52). Documented at /sources/git-repo.md §Notable entities.
2026-08-17 working-tree addition — celvivo_commercial/1331651_20260630_131201.pdf (56 KB, 2026-06-30 quote PDF migrated into a new folder; untracked) — companion to the existing 05-Documents/Products/Celvivo/Industrial-Customers/ commercial-docs subtree. The new folder name signals Robin may be consolidating "Celvivo commercial" documents into a separate vault subtree rather than continuing to nest them under 05-Documents/Products/Celvivo/Industrial-Customers/ (which is the prior convention). If the convention holds, future CelVivo commercial PDFs / quotes / pricing tables will land in celvivo_commercial/ instead of 05-Documents/Products/Celvivo/Industrial-Customers/; if it doesn't hold, it's a one-off folder for the 6-30 quote. Watchlist trigger: if a second PDF or commercial doc lands in celvivo_commercial/ by the next git-repo fetch, the convention change is real; if it stays single-entry, it's a one-off.
Work-rhythm snapshot (2026-07-16)
From /sources/vault-mtime-snapshot-2026-07-16.md (last full mtime census):
2026-07-05 CelVivo 文献精读最后一次 (1 篇)
2026-06-26 销售培训物料最后一次更新 (v9 PPT + 逐字稿)
2026-06-18 memory/ 最后一次 daily report
2026-06-09 vault commit 最后一次
2026-06-06 CelVivo protocol 系列入库最后一次
2026-06-04 weekly report 最后一次
Conclusion (snapshot date): Past 3 weeks (post 2026-07-05) had 0 CelVivo activity. This is real state, not an OpenWiki gap. The snapshot recommends Robin write a memory/2026-07-16-*.md daily report to capture the gap. This also means the OpenWiki cron vault-mtime-snapshot connector is the canonical work-rhythm evidence — it complements the git-repo connector (commit history) and NocoDB (last-touched metadata).
Cross-vendor route map
Each research output eventually lands in one of the vendor synthesis themes:
| Research artifact | Primary route | Secondary |
|---|---|---|
| CelVivo deep reads + sales ammunition | /themes/01-organoid-equipment.md |
CelVivo industrial-customers program → /commitments.md |
| 3Brain deep reads + end-customer dossiers | /themes/01-organoid-equipment.md |
3Brain conference positioning → /commitments.md 3brain-coreplate-2026-conference-positioning |
| Cellink deep reads + BIO X customer evidence | /themes/02-bioprinting.md |
New Lumen X release → /commitments.md cellink-volumetric-lumen-x-release |
| Femtobiomed deep reads + CellShot-TriArm demo plans | (theme gap — Femtobiomed has no synthesis theme yet) | 01-Active-Sales/ plans → /commitments.md |
| Adjacent non-vendor (MSC / canine / PEMF / 综述) | class-organoid-3d-bioprinting theme row on /themes.md |
— |
| China regulatory (CDE / Order 818 / CGT) | /commitments.md items china-cde-cell-gene-therapy-rules-2026 / china-order-no-818-clinical-translation / china-cgt-2026-july-developments |
— |
| Distributor / agent | /sources/distributors-china-2026.md + /sources/agents.md + /open-questions.md agent-dong-huiqun-celvivo |
— |
Personal-infra and adjacent work
These are source-anchored but not vendor-anchored — they live here for traceability but do not earn a /themes.md row:
- ITX 24h host build (first observed 2026-07-31; still untracked) —
03-Resources/ITX-24h-Host/ITX_24h_Host_v18_Config_2026-07-31.md. Plan: mATX + i5-12400 + DDR4-2666 32G + 板载 Realtek 1Gb + Intel PRO/1000 GT 双网卡 NAS 隔离. Budget ¥2,985.82, 10/11 parts arrived. Status: paused awaiting last #8/#9 cable parts. Tracked as/commitments.mditx-24h-host-build-2026-q3(Owner: me). - OpenWiki cheat sheet (2026-07-27) —
OpenWiki速查手册_2026-07-27.md(vault root, untracked). Companion to/sources/OpenWiki速查手册.md(the wiki copy). - 4 vendor + 4 application + 4 agents SOP iterations — the cluster of training materials under
06-Sales/Content/Training-Materials/is iterated in place without commits; latest isCelVivo_销售培训_PPT_v9(06-26 14:13).
Cross-cutting relationship
- Touched by
/themes/03-ai-agents.md— M3 agent synthesis step (02:00 cron) writes research evidence into the synthesis themes; literature-deep-read SOP is what produces the canonical deep-read pages; sales-ammunition query skill routes ClinoReactor-related questions. - Touched by
/themes/04-local-llm.md— RAGFlow KB (Celvivo / 3Brian / Cellink) is the deep retrieval surface behind every vendor deep read; SeaFile is the PDF + figure storage; NocoDB is the metadata catalog; Wiki.js is the public publishing target. The 2026-07-17 desktop service-down incident materially degrades the LDR pipeline. - Output routes into
/themes/01-organoid-equipment.mdand/themes/02-bioprinting.md— most of the deep reads and vendor evidence in this theme ends up at the vendor synthesis themes. - Outputs routed into
/commitments.md— China regulatory items + vendor-channel verification items + ITX host build + CellShot-TriArm demo plans. - Outputs routed into
/open-questions.md—agent-dong-huiqun-celvivois the only currently active entry; it is anchored to02-Clients/Agents/董慧群.mdand is the kind of "ambiguous people/org relationship" gap the wiki brief calls out.
Backlog for this theme
- Femtobiomed synthesis page —
Femtobiomed CellShot / CellPick / TriArmhas a vault bucket and aFemtoBiomed_electroporationRAGFlow KB (123 docs) but no synthesis theme. Currently routes as adjacent cross-sell into01and02. Consider promoting tothemes/06-femtobiomed.mdif vendor-channel evidence accrues. - Hodge / Lee / Parate synthesis — 3 adjacent deep reads added 2026-07-28 are not yet synthesized to
/sources/. Run LDR Step 8 (NocoDB PATCH + Wiki.js publish + OpenWiki commit) when ready. - Work-rhythm snapshot connector — currently a one-shot
find -mtimeshell command (see/sources/vault-mtime-snapshot-2026-07-16.mdheader). Promote to a weekly cron + auto-write to/sources/vault-mtime-snapshot-weekly.mdso the work-rhythm signal is durable, not single-snapshot. - End-customer dossier cross-agent page — 11+ dossiers live in private vault; consider adding a redacted
[name, focus, vendor, region, vault-path]table to/sources/agents.mdparallel to the distributor profile pattern. Robin decision pending. - CellShot-TriArm demo plan v3 — current demo plans are v1 (2026-07-21) and v2 (2026-07-22, 邮件用 + 老师版 two-commit split). No v3 yet; the v2 plan lives in vault commit history
1787702c/62877d1f/62d09c5f. Promote to/commitments.mdwhen v3 lands. - MOC pattern extension (2026-08-10 onward) — Robin created the first MOC
(
04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md, commit6b717aef, 95 lines, 沙牛《AI 时代的 Obsidian 公开课》课时 1 pattern); the MOC'srelated:list already names the next planned MOC —[[MOC-3Brain-HD-MEA]]— plus[[02-Clients/Agents/_known_associations]]and[[02-Active-Deals/CellShot-TriArm-Demo-计划-v2-老师版-2026-07-20]]. Track on the next git-repo fetch whether the MOC pattern extends to MOC-3Brain-HD-MEA, MOC-Cellink-BIO-X, MOC-Femtobiomed-CellShot, etc. If ≥3 MOCs land, consider adding a/themes.mdannex row onvault-knowledge-architectureand a/sources/page that maps the MOC graph (file → topics → cross-refs → flywheel cron hooks). - Phase A frontmatter batch rollout (2026-08-10 onward) — Phase A standardized 6 deep-read notes with the 6-field frontmatter (doi / journal / year / volume / pages / authors / pmid); ~1,196 deep-read notes remain without the new fields. Track rollout cadence — if Robin completes the batch on a fixed cadence (e.g. daily/weekly cron), document the cadence here so future agents can answer "what is the frontmatter hygiene status of the vault?".
What to read next
| Question | Go to |
|---|---|
| What is the canonical LDR master template? | /sources/ldr-report-template.md |
| What did the 7-27 SOP-vs-implementation pass reveal? | /sources/2026-07-27-4-27-sop-vs-implementation.md |
| What is the current Obsidian vault manifest? | /sources/git-repo.md |
| What is the 30-day literature deep-read digest? | /sources/literature.md |
| What is in the CelVivo sales ammunition kit? | /sources/sales-ammunition.md |
| What is the China 261-dealer map? | /sources/distributors-china-2026.md |
| Who is Robin actively working with? | /sources/agents.md |
| What is the work-rhythm cadence? | /sources/vault-mtime-snapshot-2026-07-16.md |
| What does the CelVivo 2026 whitepaper say? | /sources/literature-celvivo-brain-whitepaper-2026.md |
| What does the Bosnjakovic 2025 PAH paper say? | /sources/literature-cel-bosnjakovic-2025-pah-deepread.md |
| What is the Raji 2026 hMOs + 3Brain story? | /sources/literature-raji-2026-deepread.md |
| What is the Tasevska 2025 BIO X SSE story? | /sources/literature-tasevska-2025-deepread.md |
| How does the agent stack consume this output? | /themes/03-ai-agents.md |
| How does the local-LLM fleet host this evidence? | /themes/04-local-llm.md |
| Where does CelVivo + 3Brain output land? | /themes/01-organoid-equipment.md |
| Where does Cellink output land? | /themes/02-bioprinting.md |
| What does Quintard 2024 say about vascularized organoid chips? | obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md (vault path; deep-read synthesis not yet split out to /sources/) |
| What does Guo 2026 say about organoid IRB ethics? | obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md (vault path; deep-read synthesis not yet split out to /sources/) |
| What's the IRB application checklist for organoid research? | templates/类器官IRB申请清单.md v1.0 (vault path; untracked) |
| What's the IRB application checklist for organoid research? | templates/类器官IRB申请清单.md v1.0 (vault path; untracked) |
| What's the IRB application checklist for organoid research? | templates/类器官IRB申请清单.md v1.0 (vault path; untracked) |
| What's the IRB application checklist for organoid research? | templates/类器官IRB申请清单.md v1.0 (vault path; untracked) |