193 KiB
193 KiB
type, title, description, resource, tags, timestamp
| type | title | description | resource | tags | timestamp | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Reference | Git repo — evidence index (Obsidian vault, Robin) | Compact manifest of Robin's Obsidian vault + the local OpenWiki wiki, ingested through the local git-repo connector. Two configured repos: obsidian-vault at /home/ldw/workspace (main branch, HEAD 9d4767c7, 2026-08-25, **5 new vault commits in the 2026-08-24T18:05Z → 2026-08-25T18:13Z 24-hour window — the SECOND consecutive single-day 5-paper LDR cluster: `089177a7` Tevonian 2026 Nat Commun vascularized liver MPS + `583859a8` Yang 2026 Stem Cell Res Ther cardiac organoid review + `9aa2af4c` Update Tevonian 2026 + Yang 2026 (CelVivo/Cellink/Mimetas/3Brain/FemtoBiomed product mapping retrofit + 净化 Robin mentions — the first post-publish vendor-mapping retrofit on the 2026-08-23/24/25 LDR cluster) + `5907cdfc` Shen 2026 Chin Med J vascularized organoids review + `9d4767c7` Zhai 2026 Sci Adv 3D skin pemphigus — combined with the 2026-08-23/24 5-paper burst, **10 papers in 48 hours = the largest sustained 2-day research output in Robin's vault activity log; the burst creates 3 new deep-read subfolders: `Vascularized-Organoids/` (Tevonian + Shen) + `Cardiac-Organoids/` (Yang) + `Skin-Organoids/` (Zhai)**) and openwiki-wiki at /home/ldw/.openwiki/wiki (main branch, HEAD 1003b92, 2026-08-25, **2 new automated wiki commits in the 2026-08-24T18:05Z → 2026-08-25T18:13Z window: `3255613` daily update 2026-08-25 + `1003b92` sources-sync 2026-08-25 — the eleventh consecutive sources-sync re-applying the 2026-08-15 count-data wipe pattern**). This page is a navigation index — content ingestion (paper deep reads, sales scripts, customer files) happens via the Hermes skill and RAGFlow, not here. |
~/.openwiki/connectors/git-repo/config.json |
|
2026-08-25T18:13:00Z |
Git repo — evidence index (Obsidian vault + OpenWiki wiki)
Compact manifest of the two local git repos configured under the
git-repo connector: Robin's Obsidian vault and the local OpenWiki
wiki. This page is a navigation index — content ingestion (paper
deep reads, sales scripts, customer files) happens via the Hermes skill
and RAGFlow, not here. Keep this page terse and structural; it should
help locate things in the vault, not summarize their content.
Connector
- Source instance:
git-repo-1(configured under~/.openwiki/connectors/git-repo/config.json) - Configured repos:
obsidian-vault→/home/ldw/workspace(Robin Obsidian vault, onmain, HEAD9d4767c7034a59d8f3206756c2dfeb3f4339c2e0as of 2026-08-25 +0800 — 5 new vault commits in the 2026-08-24T18:05Z → 2026-08-25T18:13Z 24-hour window: the 2026-08-24/25 5-paper LDR cluster (SECOND consecutive single-day 5-paper LDR burst) —089177a7Tevonian 2026 Nat Commun 血管化肝 MPS deep read (PMID 41634021) +583859a8Yang 2026 Stem Cell Res Ther cardiac organoid review (PMID 41963991) +9aa2af4cUpdate Tevonian 2026 + Yang 2026 (CelVivo/Cellink/Mimetas/3Brain/ FemtoBiomed product mapping retrofit + 净化 Robin mentions — the FIRST post-publish vendor-mapping retrofit on the 2026-08-23/24/25 LDR cluster) +5907cdfcShen 2026 Chin Med J vascularized organoids review (PMID 42268296) +9d4767c7Zhai 2026 Sci Adv 3D skin pemphigus (PMID 41512055). Combined with the 2026-08-23/24 5-paper burst, 10 papers in 48 hours = largest sustained 2-day research output in Robin's vault activity log. The cluster creates 3 new04-Literature/Deep-Reads/subfolders:Vascularized-Organoids/(Tevonian + Shen) +Cardiac-Organoids/(Yang) +Skin-Organoids/(Zhai) — Robin expands the deep-read taxonomy from ~19 to ~22 per-vendor / per-application-domain subfolders in a single day. The new9aa2af4cretrofit commit is the first synthesis-grade post-publish LDR touch on the 2026-08-23/24/25 cluster — the prior 5 papers (Ajongbolo + Kim + Tian + Aiello + CelVivo App Note) have NOT had this retrofit applied yet, only the new Tevonian + Yang pair get the retroactive 4-vendor mapping).openwiki-wiki→/home/ldw/.openwiki/wiki(the OpenWiki knowledge base itself, onmain, HEAD1003b92f3a1e43197ec8e21e7f69fd5db38316e7as of 2026-08-25T +0800 — 2 new wiki-side commits in the 2026-08-24T18:05Z → 2026-08-25T18:13Z 24-hour window:3255613chore: daily update 2026-08-25 +1003b92chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-25) — the eleventh consecutive sources-sync re-applying the 2026-08-15 count-data wipe pattern).
- Auth: local paths only — no remote, no credentials.
- Latest fetch:
2026-08-25T18:13:00Z(raw manifest~/.openwiki/connectors/git-repo/raw/2026-08-25T18-13-42-494Z/manifest.json). - Source config:
~/.openwiki/connectors/git-repo/config.json - State:
~/.openwiki/connectors/git-repo/state.jsonrecordslatestIdsper repo; the 2026-08-25T18:13Z fetch observed vault HEAD bumped fromfb017e4f(2026-08-23/24, the prior 5-paper burst landed at the 2026-08-24T18:05Z fetch) to9d4767c7(2026-08-25 — 5 new vault commits in the 24-hour window, the SECOND consecutive single-day 5-paper LDR cluster), and observedopenwiki-wikibumped from127c2dc(2026-08-24T18:05Z fetch) to1003b92(2 new automated wiki commits in the 24-hour window:3255613chore: daily update 2026-08-25 (2026-08-25T02:23 +0800; committed 17 files from the prior dirty set pergit show --stat 3255613) +1003b92chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-25, 2026-08-25T02:30 +0800 — the eleventh consecutive sources-sync re-applying the 2026-08-15 count-data wipe pattern after25079252026-08-15 +997b6482026-08-16 +be492852026-08-17 +1fc73ae2026-08-18 +dcb53a22026-08-19 +bd303392026-08-20 +f6c25762026-08-21 +43d45482026-08-22 +8f8f7672026-08-23 +127c2dc2026-08-24 + now1003b922026-08-25).
obsidian-vault — working-tree status (2026-08-25)
-
Branch:
main -
HEAD:
9d4767c7034a59d8f3206756c2dfeb3f4339c2e0(vault HEAD bumped fromfb017e4f(2026-08-23/24, the prior 5-paper burst) →9d4767c7(2026-08-25) across the 2026-08-25T18:13Z fetch — 5 new commits in the 2026-08-24T18:05Z → 2026-08-25T18:13Z 24-hour window. The 2026-08-24/25 cluster is the SECOND consecutive single-day 5-paper LDR burst — combined with the 2026-08-23/24 5-paper burst (Ajongbolo + Kim + Tian + Aiello + CelVivo App Note), Robin has produced 10 LDR papers in 48 hours, the largest sustained 2-day research output in Robin's vault activity log. The cluster creates 3 NEW04-Literature/Deep-Reads/subfolders —Vascularized-Organoids/(Tevonian + Shen) +Cardiac-Organoids/(Yang) +Skin-Organoids/(Zhai) — Robin expands the deep-read folder taxonomy from ~19 to ~22 in a single day. Crucially, the cluster includes the FIRST post-publish vendor-mapping retrofit commit (9aa2af4c) which adds CelVivo / Cellink / Mimetas / 3Brain / FemtoBiomed product mapping + 净化 Robin mentions to the Tevonian + Yang files — the prior 5 papers (Ajongbolo + Kim + Tian + Aiello + CelVivo App Note) have NOT had this retrofit applied retroactively. -
mtime activity in window: 5 new committed files in the 2026-08-24T18:05Z → 2026-08-25T18:13Z 24-hour window — all 5 land at per-vendor / per-application-domain subfolders (different pattern from the prior 5-paper cluster which all landed at the
04-Literature/Deep-Reads/root). Manifest paths confirm 3 NEW subfolders:Tevonian_2026_Nat_Commun_Vascularized_Liver_MPS.mdYang_2026_Stem_Cell_Res_Ther_Cardiac_Organoid_Review.md+Shen_2026_Chin_Med_J_Vascularized_Organoids_Review.md+Zhai_2026_Sci_Adv_3D_Skin_Pemphigus.md— plus the Tevonian + Yang in-placeMtouches from the9aa2af4cretrofit commit. Chronological commit order (mtime ascending per manifest):089177a72026-08-25 Tevonian 2026 vascularized liver MPS →583859a82026-08-25 Yang 2026 cardiac organoid review →9aa2af4c2026-08-25 Tevonian + Yang product-mapping retrofit →5907cdfc2026-08-25 Shen 2026 vascularized organoids review →9d4767c72026-08-25 Zhai 2026 3D skin pemphigus. The 2026-08-23- 2026-08-24 LDR burst files (Ajongbolo + Kim + Tian + Aiello +
CelVivo App Note +
deepread_40240593/pipeline workspace) all carry forward unchanged from the 2026-08-24T18:05Z fetch. Thecelvivo_commercial/+templates/untracked dirs continue to carry forward (now 9-day carry-forward at this fetch — was 8-day at the 2026-08-24T18:05Z fetch). TheReview/zhou2023_computer_vision_microfluidics.mdfirst-entry file is unchanged from the 2026-08-24T18:05Z fetch (mtime 2026-08-11, 14-day carry-forward in the untracked set at this fetch — was 13-day at the 2026-08-24T18:05Z fetch; the structural signal continues to weaken per the Notable-entity entry on theReview/subfolder).
-
Ahead of origin/main: 30 commits new since 2026-08-03 fetch (+5 from the prior 25-commit baseline at the 2026-08-24T18:05Z fetch — the 5 new commits land on top of the 25-commit carry-forward).
-
Dirty: yes — the untracked file set is partially changed: the 8 ×
02-Clients/Agents/区域-2026-0807.mddistributor-rebuild files + 14 working-folder files + 2 untracked dirs from the 2026-08-17T18:09Z fetch carry forward unchanged, and theReview/zhou2023_computer_vision_microfluidics.mdfirst-entry in the newReview/subfolder is still untracked (Robin has not yet committed it) — 14-day carry-forward at this fetch (was 13-day at the 2026-08-24T18:05Z fetch); the structural signal continues to weaken per the Notable-entity entry on theReview/subfolder (the subfolder has been a single-entry watchlist since 2026-08-13, now 12 fetches silent). Thecelvivo_commercial/+templates/untracked dirs continue to carry forward (now 9-day carry-forward at this fetch — was 8-day at the 2026-08-24T18:05Z fetch); thedeepread_40240593/untracked pipeline workspace also continues to carry forward (now 2-day carry-forward — was 1-day at the 2026-08-24T18:05Z fetch); no NEW untracked dirs at this fetch. -
Working-tree status (raw manifest, abbreviated):
Status Path A(committed 2026-08-12,e542c977)04-Literature/Deep-Reads/Liver/2026-08-12_Liang_2026_SciRep_liver_organoid_fibrosis_platform.md— NEW external evidence (Liang Y et al. Sci Rep 2026 DOI 10.1038/s41598-026-42990-2, PMID 41857098, 3 轨道 Hep-Orgs + Cho-Orgs + HSC, DAPT+Dex P1-P10 长程成熟, TGFβ 激活体外纤维化模型; Wiki.js Id=1716, NocoDB Id=770, SeaFile PDF + 7 真图)M(committed 2026-08-12,8699a154)same Liang 2026 file — page 946 9 项 SOP 重写版 (105+/122- lines) M(committed 2026-08-12,aacba7aa)same Liang 2026 file — frontmatter title 改中文 + 与正文 H1 一致 (1-line touch) M(committed 2026-08-12,297f106d)same Liang 2026 file — 修齐 page 934 标杆 (H1 去括号/元数据用bold/📄PDF文件名, 5+/4- lines) A(committed 2026-08-16,a4fa5a32)obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md— NEW external evidence (Guo Z, Zhang N 2026 Front Cell Dev Biol DOI 10.3389/fcell.2026.1721946 — IRB / ethics systematic review; Wiki ID 1724, NocoDB Id 3298, 170 lines + 3 张真图; "与我们的产品" table lists CelVivo ClinoStar ⭐⭐⭐⭐ [临床转化类器官的伦理合规——7 大要点直接适用 IRB 申请] + Mimetas OrganoPlate ⭐⭐⭐⭐ [类器官 + 免疫细胞共培养伦理审查依据] + Emulate Organ-Chip ⭐⭐⭐; 3 commits2e6f5989→00f824f2→a4fa5a32= adds → -v2 修图床 → -v3 补 Fig 1)A(committed 2026-08-16,0fc8db24)obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md— NEW external evidence (Quintard C et al. 2024 Nat Commun DOI 10.1038/s41467-024-45710-4 — microfluidic platform for vascularized organoid chips; Wiki IDs 1719/1720/1722, NocoDB Id 3297; 4 commits0fc8db24→290e9635→24c713de→4073abf4= adds 189 lines → -v2 修图床/双 H1/落款 → -v3 Wiki.js 自带图床 6 张图 → -v4 转发语标题/落款加粗/删 3Brain; "与我们的产品" table lists Mimetas OrganoPlate ⭐⭐⭐⭐ [直接对标: Phaseguide 微流控技术用于血管化/肾/肠 organ-on-chip] + CelVivo ClinoStar ⭐⭐⭐ [类器官前段成熟期培养: BVO 在 hiPSC 分化到 day 15 需要悬浮旋转培养, ClinoStar 是该步骤的金标准; day 15 后才转入芯片, ClinoStar 是完整工作流的前置] + Emulate Organ-Chip ⭐⭐⭐)M(committed 2026-08-10)04-Literature/Deep-Reads/Organoid/2026-07-29_Organoids_disease_modeling_treatment_2026_review.md(Phase A batch frontmatter —volume/pages/authorsarray; also touched by6b717aeffor related back-link)M(committed 2026-08-10)CelVivo_精读报告_04_bioRxiv_PAH_Metabolomics.md(Phase A batch frontmatter —volume/pages/authorsarray; also touched by6b717aef)M(committed 2026-08-10)obsidian-vault/04-Literature/Deep-Reads/3Brain/shin-2024-thalamocortical-organoids-22q11ds.md(Phase A batch frontmatter; also touched by6b717aef)M(committed 2026-08-10)obsidian-vault/04-Literature/Deep-Reads/Cells/fernandez-vallone-2026-thsdc-brain-organoids.md(Phase A batch frontmatter; also touched by6b717aef)M(committed 2026-08-10)obsidian-vault/04-Literature/Deep-Reads/NBME-ShapeConformal/literature-liu-2026-nbme-shape-conformal-organoid.md(Phase A batch frontmatter; also touched by6b717aef)M(committed 2026-08-10)类器官综述_CMOS_HD_MEA_类器官电生理_2026-06-05.md(Phase A batch frontmatter; also touched by6b717aef)M(committed 2026-08-10)04-Literature/Deep-Reads/wang2024-org-on-chip.md(方案 2 样品 — 6 frontmatter fields + 7 alt descriptions; also touched by6b717aef)A(committed 2026-08-10)04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md(方案 1 — first MOC file; 95 lines; 沙牛《AI 时代的 Obsidian 公开课》课时 1 pattern;related:already lists[[MOC-3Brain-HD-MEA]]as a forward link)??(untracked)02-Clients/Agents/全国经销商地图-2026-0807.md+ 7 区域*2026-0807.mdfiles (8-07 distributor baseline refresh — see below)??(untracked, NEW 2026-08-17)celvivo_commercial/1331651_20260630_131201.pdf— NEW untracked directory; the 6-30 quote PDF Robin migrated into a newcelvivo_commercial/folder; companion to the existing05-Documents/Products/Celvivo/Industrial-Customers/commercial-docs subtree??(untracked, NEW 2026-08-17)templates/类器官IRB申请清单.md— NEW untracked directory; the IRB application checklist derived from the Guo 2026 ethics-review deep-read (180 lines; 7 mandatory points [样本来源/知情同意/数据隐私/共培养主体性/3R 动物福利/跨境监管/长期保存与终止使用] + 5 customer Q&A + China vs International flow table + 10 attachments + 7 citations); Robin's first customer-facing template derived from a single deep-read — materializes the "Robin 业务定位: 类器官厂家给三甲医院 IRB 申请的标准模板 + Robin 客户培训材料核心" framing from the Guo 2026 deep-read??(untracked)04-Literature/Deep-Reads/Brain/2026-08-06_Parfitt_GM_et_al_NatCommun_2024_DJ1_LOF_midbrain_organoid_PD.md??(untracked)Liu2026_NBME_shape_conformal_organoid.md??(untracked)Miao2025_Cell_v2.md??(untracked)Miao2025_Cell_vascularized_organoid.md??(untracked)Microbioreactor_2026_Rosero_FrontBioeng.md??(untracked)__pycache__/literature_deepread_v6.cpython-312.pyc— NEW (2026-08-13) Python compiled cache file (build noise from runningliterature_deepread_v6.py, ignored)??(untracked)dify精读进度-20260805.md??(untracked)literature_deepread_v6.py??(untracked)obsidian-vault/04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md— NEW (2026-08-13) first entry in the newReview/subfolder (Zhou 2023 computer vision + microfluidics — Robin deep-read in progress, untracked, future-commit candidate)??(untracked)obsidian-vault/rustdesk-selfhosted-2026-08-05.md??(untracked)retinal_organoid_deep_read_2026-08-07.md??(untracked)文悦精读流水线.yml+ v2/v3/v4/v5-clean variantsThe 8 untracked
*2026-0807.mdfiles in02-Clients/Agents/are the 2026-08-07 distributor baseline refresh — see the "Distributor map refresh (2026-08-07)" section below for synthesis. The 2 NEW untracked files this fetch are: (a)Review/zhou2023_computer_vision_microfluidics.md— first entry in a new deep-read subfolder (see Notable-entity entry below); (b)__pycache__/...pyc— build noise, ignored.
Recent commits (latest first)
| Date | Hash | Note |
|---|---|---|
| 2026-08-25 | 9d4767c7 |
feat: Zhai 2026 Sci Adv 3D skin pemphigus (PMID 41512055) — adds obsidian-vault/04-Literature/Deep-Reads/Skin-Organoids/Zhai_2026_Sci_Adv_3D_Skin_Pemphigus.md — FIRST file in the new Skin-Organoids/ subfolder, single-shot LDR entry. Zhai T et al. Sci Adv 2026 — 3D skin organoid + pemphigus disease-modeling application domain; net-new application domain (autoimmune dermatology + 3D skin) to Robin's deep-read set, distinct from cancer organoid (cancer) / brain organoid (Raji 2026 etc.) / vascularized organoid (Tevonian + Shen in this cluster) / cardiac organoid (Yang in this cluster) / liver organoid (Liang 2026) / brain-tumor organoid buckets. Vendor anchor mapping: TBD on the wiki-side synthesis page; skin organoid is adjacent to CelVivo ClinoReactor (long-term 3D skin culture) but no vendor callouts confirmed in the manifest entry. Future implication: skin organoid is a candidate workflow for the Robin CelVivo industrial-customers program (cosmetic + dermatology pharma R&D). |
| 2026-08-25 | 5907cdfc |
feat: Shen 2026 Chin Med J vascularized organoids review (PMID 42268296) — adds obsidian-vault/04-Literature/Deep-Reads/Vascularized-Organoids/Shen_2026_Chin_Med_J_Vascularized_Organoids_Review.md — FIRST review-type file in the new Vascularized-Organoids/ subfolder, single-shot LDR entry. Shen Y et al. Chin Med J 2026 — vascularized organoid systematic review (peer-reviewed Chinese-language journal); companion to the Tevonian 2026 vascularized liver MPS deep-read in the same cluster. Vendor anchor mapping: TBD on the wiki-side synthesis page; vascularized organoid literature is CelVivo ClinoStar-adjacent (long-term stable vascular maturation) + Mimetas OrganoPlate-adjacent (organ-on-chip for vascularized microenvironment) + Cellink BIO X-adjacent (decellularized scaffold for vascularization). |
| 2026-08-25 | 9aa2af4c |
Update Tevonian 2026 + Yang 2026: add CelVivo/Cellink/Mimetas/3Brain/Femtobiomed product mapping + 净化 Robin mentions — M touches obsidian-vault/04-Literature/Deep-Reads/Cardiac-Organoids/Yang_2026_Stem_Cell_Res_Ther_Cardiac_Organoid_Review.md + M touches obsidian-vault/04-Literature/Deep-Reads/Vascularized-Organoids/Tevonian_2026_Nat_Commun_Vascularized_Liver_MPS.md — FIRST post-publish vendor-mapping retrofit commit in Robin's LDR pipeline; the prior 5-paper 2026-08-23/24 cluster (Ajongbolo + Kim + Tian + Aiello + CelVivo App Note) did NOT have this retrofit applied retroactively; only the new Tevonian + Yang pair get the retroactive 5-vendor mapping (CelVivo + Cellink + Mimetas + 3Brain + Femtobiomed) plus 净化 Robin mentions. Robin's LDR SOP iteration: the 5-vendor product-mapping table is now a standard post-publish step for new LDR commits. The 净化 Robin mentions specifically removes any direct attribution strings ("Robin"s, "Robin 8-XX 实战沉淀" patterns, etc.) that might leak into the production deep-read narrative. |
| 2026-08-25 | 583859a8 |
feat: Yang 2026 Stem Cell Res Ther cardiac organoid review (PMID 41963991) — adds obsidian-vault/04-Literature/Deep-Reads/Cardiac-Organoids/Yang_2026_Stem_Cell_Res_Ther_Cardiac_Organoid_Review.md — FIRST file in the new Cardiac-Organoids/ subfolder, single-shot LDR entry. Yang L et al. Stem Cell Res Ther 2026 — cardiac organoid review (companion to Tian 2025 Nat Commun cardiac epicardium mTOR paper from the prior 5-paper cluster). The new Cardiac-Organoids/ subfolder joins the existing Cardiac/ subfolder (2 prior papers) — Robin has expanded the cardiac application-domain treatment from a sparse 2-paper bucket to a dedicated subfolder. Vendor anchor mapping: TBD; the 9aa2af4c retrofit commit updated the file with the 5-vendor mapping (CelVivo + Cellink + Mimetas + 3Brain + Femtobiomed). |
| 2026-08-25 | 089177a7 |
feat: Tevonian 2026 Nat Commun 血管化肝 MPS deep read (PMID 41634021) — adds obsidian-vault/04-Literature/Deep-Reads/Vascularized-Organoids/Tevonian_2026_Nat_Commun_Vascularized_Liver_MPS.md — FIRST file in the new Vascularized-Organoids/ subfolder, single-shot LDR entry. Tevonian et al. (2026) Nat Commun — vascularized liver MPS (microphysiological system) deep read. Companion to the existing Liver/ subfolder entries (Liang 2026 fibrosis platform etc.) — this adds the vascularization dimension to the liver organoid application-domain bucket. Vendor anchor mapping: TBD; the 9aa2af4c retrofit commit updated the file with the 5-vendor mapping (CelVivo + Cellink + Mimetas + 3Brain + Femtobiomed). |
| 2026-08-23 | fb017e4f |
feat: CelVivo App Note 2026 shear stress ClinoStar vs orbital shaker (Wiki.js 1747) — adds obsidian-vault/04-Literature/Deep-Reads/CelVivo_Shear_Stress_AppNote_2026.md (10,145 bytes, single-shot entry) — NEW vendor-anchored CelVivo evidence: Stougaard Borgen Løschenkohl, Sedighi Frandsen (CelVivo App Note 2026) head-to-head ClinoStar® vs orbital shaker, 15-day HepG2/C3A + embedded Caco-2 + brain organoid; F-actin + DAPI staining shows ClinoStar preserves cytoskeleton integrity vs orbital shaker structural decay; ATP + BCA + 3 biological replicates per condition; SP5D 24-well ball-plate 1000 cells/aggregate pre-conditioning; ClinoReactor® vessel (CelVivo 10004-12) in ClinoStar® system (30003) vs ULA 6-well + Steinberg SBS-LVS-100 shaker; low-shear fFSS confirmation |
| 2026-08-23 | f2118a62 |
feat: Aiello & Bagni 2025 biorxiv Rotating Chamber brain organoid 精读 (Wiki.js 1746) — adds obsidian-vault/04-Literature/Deep-Reads/Aiello_Bagni_2025_biorxiv_Brain_Organoid_Fluid.md (11,731 bytes, single-shot entry) — NEW CelVivo-aligned evidence: EMBO Reports 投稿版 (Aiello_Bagni_EMBO R_050325) — COMSOL Multiphysics 6.2 CFD quantification of Rotating Chamber (RC) shear stress field; chamber geometry 78.3 mm × 24.2 mm (outer) / 37.7 mm × 8.8 mm (inner); shear stress < 20 mPa confirmed (vs qualitative "low-shear" only previously); 0-300 objects per chamber all stable low-shear across densities 1010/1020/1030; multi-batch + multi-iPSC line brain organoid morphology PCA (CV <15% vs static >30%); scRNA-seq OXPHOS profiling; SOX2/Nestin/PAX6 + DCX + TBR1/SATB2/MAP2 multi-marker IHC; first quantitative confirmation of CelVivo RC low-shear claim |
| 2026-08-23 | 40b357b8 |
feat: Tian 2025 NatCommun 心外膜 mTOR 精读 (Wiki.js 1745) — adds obsidian-vault/04-Literature/Deep-Reads/Tian_2025_NatCommun_Epicardium_mTOR.md (15,578 bytes, single-shot entry) — NEW cardiac organoid evidence: Tian Y, Lucena-Cacace A, Tani K et al. (2025) Nat Commun DOI 10.1038/s41467-025-60934-8 — Torin1 (dual mTORC1/2 inhibitor, 200 nM) drives hiPSC epicardium maturation from embryonic to adult phenotype; qHSC→aHSC EMT reactivation pathway; bulk RNA-seq 379 DEGs; PCA explains 28.53% PC1 + 36.01% PC2 variance; co-culture hiPSC epicardium + ventricular cardiomyocyte EB → TNNI3 upregulation (paracrine maturation); mTORC1/2 dual inhibition is critical (Rapamycin alone insufficient); YBX3 + MAFF TF candidates via siRNA knockdown; first cardiac epicardium paper since MOC 心肌 maturation track started |
| 2026-08-23 | 5f02489a |
feat: Kim 2025 NatCommun 液态金属 3D MEA 精读 (Wiki.js 1744) — adds obsidian-vault/04-Literature/Deep-Reads/Kim_2025_NatCommun_Liquid_Metal_3D_MEA.md (13,567 bytes, single-shot entry) — NEW 3D-MEA / electrophysiology evidence: Kim E, Jeong E, Hong YM et al. (2025) Nat Commun DOI 10.1038/s41467-024-55752-3 — magnetically reshapable EGaIn (eutectic gallium-indium) liquid-metal 3D MEA pillar array via microfluidic direct-ink-writing; pillar height 25-310 µm linearly controlled by print speed (R²>0.95, n=12, SEM<5%); pillar diameter to 14 µm (single-neuron scale); parylene-C selective sidewall encapsulation (only tip conductive); hPSC cortical organoid 120-day maturation (dual-SMAD inhibition + FGF2/EGF + BDNF/NT3); 6-marker IHC (MAP2/GFAP/VGLUT1/SATB2/CTIP2) showing 6-layer cortical-like structure; Ni magnetic layer for magnetic reshaping; 64-channel MEA + SU spike + network synchronization; third flexible-electronics / 3D-MEA paper this cycle after Liu 2026 (NBME shape-conformal porous framework) + Sharma 2026 (60-channel MCS MEA retinal organoid) — direct 3Brain HD-MEA competitive pressure signal |
| 2026-08-23 | ad4abcde |
feat: Ajongbolo 2025 Cells 脑类器官综述精读 (Wiki.js 1743) — adds obsidian-vault/04-Literature/Deep-Reads/Ajongbolo_2025_Cells_Brain_Organoids_Review.md (11,367 bytes, single-shot entry) — NEW brain-organoid review evidence: Ajongbolo AO, Langhans SA (2025) Cells DOI 10.3390/cells14110842 — comprehensive brain-organoid + assembloid review covering (i) whole-brain vs region-specific vs complex systems (assembloid + OoC + tumoroid + transplant); (ii) 4-tier characterization (morphological / biochemical / functional / omics); (iii) disease modeling across neurodevelopmental (microcephaly / macrocephaly / ASD / Rett / fragile X / Timothy syndrome) + neurodegenerative (AD / PD / HD / ALS) + brain tumor (glioblastoma / medulloblastoma / AT/RT); (iv) drug discovery + HTS pathways; first brain-organoid review since the 2026-07-29 Organoids 2026 disease-modeling review; mentions ClinoStar / orbital shaker reagent-supply chain |
| 2026-08-16 | a4fa5a32 |
literature: review 类 Guo 2026 -v3 补 Fig 1 — in-place update ID 1724, 3 张图全 |
| 2026-08-16 | 00f824f2 |
literature: review 类 Guo 2026 -v2 修图床 — in-place update ID 1724, 加 2 张 Wiki.js 自带图 |
| 2026-08-16 | 2e6f5989 |
literature: 精读 Guo 2026 Front Cell Dev Biol - 类器官伦理审查 (review 类, Wiki ID 1724, NocoDB Id 3298) — NEW external evidence (类器官研究 IRB / 伦理审查 7 大强制要点系统综述, 嘉兴市第一医院 + 嘉兴大学医学院视角) |
| 2026-08-16 | 4073abf4 |
literature: 精读 Quintard 2024 -v4 — 转发语标题/落款加粗/删3Brain |
| 2026-08-16 | 24c713de |
literature: 精读 Quintard 2024 -v3 Wiki.js 自带图床 (ID 1722, 6 张图永久) |
| 2026-08-16 | 290e9635 |
literature: 精读 Quintard 2024 -v2 修图床/双 H1/落款 (Wiki ID 1720) |
| 2026-08-16 | 0fc8db24 |
literature: 精读 Quintard 2024 Nat Commun - 微流控血管化类器官芯片 (Wiki ID 1719, NocoDB Id 3297) — NEW external evidence (10 通道并行微流控 + hiPSC-BVO 30 天功能性灌注培养 + 跨类器官验证) |
| 2026-08-12 | 297f106d |
literature: 修齐 page 934 标杆 — H1 去括号 / 元数据用 bold / 📄PDF 文件名 (Liang 2026 v3) |
| 2026-08-12 | aacba7aa |
literature: frontmatter title 改中文 + 与正文 H1 一致 (Liang 2026 v2) |
| 2026-08-12 | 8699a154 |
literature: Liang 2026 Sci Rep liver organoid fibrosis - page 946 9 项 SOP 重写版 (Liang 2026 v2; 105+/122- lines; core-question / research-model / 6-finding 3-stage tables / 6 SeaFile Fig / "与我们的产品" 4-star / 4-paper refs / 转发语 / 完整落款) |
| 2026-08-12 | e542c977 |
literature: Liang 2026 Sci Rep liver organoid + fibrosis platform (Id=770 NocoDB) — NEW external evidence (3 轨道 Hep/Cho/HSC + DAPT+Dex P1-P10 长程成熟 + TGFβ 激活 HSC 体外纤维化模型; 7/7 Ollama qwen2.5vl 视觉审核通过; SeaFile 7/7 公网 200 验真; 飞轮 PATCH comm Id=87 + product Id=10 + NocoDB PATCH 770) |
| 2026-08-10 | d97b39ed |
Phase A 批量：6 篇精读加 Front Matter 6 字段 (doi/journal/year/volume/pages/authors/pmid) — Organoids 2026 review + CelVivo PAH + Shin 2024 + Fernandez Vallone 2026 + Liu 2026 + 类器官综述_CMOS_HD_MEA |
| 2026-08-10 | 3b929c2f |
wang2024 方案 2 样品：6 个 Front Matter 字段 + 7 张图加 alt 描述 — wang2024-org-on-chip.md |
| 2026-08-10 | 6b717aef |
MOC 方案 1 样品：建 1 个 MOC + 7 篇加 Front Matter (related: 反链) — first MOC MOC-类器官与3D培养.md created; 7 papers got related: back-link frontmatter |
| 2026-08-09 | a14758b1 |
精读: Wang 2024 Theranostics 类器官-芯片综述 (7 张配图 + Wiki.js ID 1700) — first Organoid-on-Chip 综述 / 7 大主题板块 |
| 2026-08-08 | d7df3830 |
cells paper v2: 双 H1 + 5张真图 (xref) — Fernandez Vallone 2026 |
| 2026-08-08 | 6c16dc05 |
精读: Fernandez Vallone 2026 Cells hiPSC 脑类器官 THSDC |
| 2026-08-07 | 65fef021 |
fix: v2 with SeaFile links — Microbioreactor 2026 |
| 2026-08-07 | 18bee69f |
feat: Microbioreactor design 2026 Front Bioeng Biotechnol Mini Review (PMID 42516424) |
| 2026-08-08 | 1614ccf9 |
fix: v11 - forwarding per skill template (Liu 2026) |
| 2026-08-08 | a7cfb8a4 |
fix: final - per Research SOP strict + clean internal traces (Liu 2026) |
| 2026-08-08 | d1e8c6dd |
fix: v5 - per Research SOP + page 946 benchmark (Liu 2026) |
| 2026-08-08 | b7882b81 |
fix: v4 - add forward message (Liu 2026) |
| 2026-08-08 | 84e93402 |
fix: v3 - Fig 3 restored from page 6, audit table removed (Liu 2026) |
| 2026-08-08 | a69ad9c4 |
literature: liu 2026 NBME shape-conformal organoid |
| 2026-08-08 | 1c05eee7 |
literature: miao 2025 cell organoid vascularization v2 |
| 2026-08-08 | a0810433 |
精读: Sharma K 2026 Cell Stem Cell 视网膜类器官血管化RGC存活与功能成熟 |
| 2026-07-29 | 2341383e |
fix(hook4): 湖北行去掉 'Robin 8 月出差高发地' 残留 (Robin 真实出差意图) |
| 2026-07-29 | aa8fd2bc |
fix(hook4): 改标题 '下次出差' → '按 xlsx 缺口', Robin 后续自规划出差路径 |
| 2026-07-29 | 4b237a82 |
feat(hook): 4 个经销商管理 Hook 升级 |
| 2026-07-29 | b9da34dc |
fix(literature): Organoids 2026 综述 - 按 literature-deep-read-review SOP 重写 |
| 2026-07-29 | 0cd44fa0 |
feat(literature): 精读 Organoids for disease modeling and treatment 2026 综述 |
| 2026-07-28 | 642e3dc6 |
feat(agent): 新增代理商技术同事董慧群档案 (推 CelVivo 产品) |
| 2026-07-28 | 2718e46d |
feat(literature): Parate 2020 SCRT — PEMF 增强 MSC 旁分泌功能促软骨再生 |
| 2026-07-28 | 032de92f |
feat: 精读 Lee 2025 Front Vet Sci 犬脂肪源 MSC 3D 球体 |
The 2026-08-16 cluster is a two-paper LDR cycle on the same day covering both an organ-on-chip microfluidic platform paper and an organoid ethical-review systematic-review paper:
- Quintard C et al. (2024) Nat Commun DOI 10.1038/s41467-024-45710-4
— a microfluidic platform for vascularized organoids-on-chip. The
paper establishes: (i) 10-channel parallel microfluidic chip (COC
热压成型, U 型捕获位 300-800 µm 可调); (ii) fibrin + Matrigel hydrogel
with Landau-Levich-Bretherton 效应 → 100% 捕获效率 in 10 sec per
channel; (iii) hiPSC-derived blood vessel organoids (BVO, day 15)
- GFP-HUVEC + 纤维细胞共培养 → 30 天功能性灌注培养; (iv) 壁剪切速率
27-2000 s⁻¹, mean 134-531 s⁻¹ (与人体毛细血管生理范围 50-1900 s⁻¹
完美匹配); (v) 层级化血管: 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管.
The 4 commits are the same single file
obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.mdwalked through Robin's standard LDR cycle: (a)0fc8db24adds the file (189 lines, single-pass entry); (b)290e9635rewrites to -v2 修图床/双 H1/落款; (c)24c713deadds -v3 Wiki.js 自带 图床 6 张图 (永久); (d)4073abf4is the -v4 转发语标题/落款 加粗 + 删 3Brain 工具名硬门槛合规修正. The "与我们的产品" table on the paper lists Mimetas OrganoPlate ⭐⭐⭐⭐ (直接对标: Phaseguide 微流控技术) + CelVivo ClinoStar ⭐⭐⭐ (类器官前段成熟期培养: BVO 在 hiPSC 分化到 day 15 需要悬浮旋转培养, ClinoStar 是该步骤 的金标准; day 15 后才转入芯片, ClinoStar 是完整工作流的前置) + Emulate Organ-Chip ⭐⭐⭐.
- GFP-HUVEC + 纤维细胞共培养 → 30 天功能性灌注培养; (iv) 壁剪切速率
27-2000 s⁻¹, mean 134-531 s⁻¹ (与人体毛细血管生理范围 50-1900 s⁻¹
完美匹配); (v) 层级化血管: 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管.
The 4 commits are the same single file
- Guo Z, Zhang N (2026) Front Cell Dev Biol DOI 10.3389/fcell.2026.1721946
— an IRB / ethical-review systematic-review paper for organoid
biomedical research. The paper establishes: (i) 7 大强制要点
(样本来源合法性 / 捐赠者知情同意 [unlimited expansion / long-term
cryopreservation / inter-lab sharing / cross-border / future
unspecified research / commercial use / withdrawal mechanism] /
数据隐私与去标识化 / 共培养产物主体性评估 [Guo 2026 首次提出] /
动物福利 3R 原则 / 跨境监管合规 [中国 / 美国 / 欧盟 / 日本 / 韩国
对照表] / 长期保存与终止使用); (ii) 中国 IRB 实务视角 + 国际
ISSCR / GDPR / OHRP 双重参照 (作者团队 = 嘉兴市第一医院医学伦理
委员会 + 嘉兴大学医学院, 中国 IRB 实践者); (iii) 共培养产物
"新伦理实体" 框架 = 类器官 + 免疫细胞共培养 (CAR-T 培养) 不构成
"新生物体" 但构成 "新伦理实体", 需要独立审查. The 3 commits are
the same single file
obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.mdwalked through Robin's standard LDR cycle: (a)2e6f5989adds the file (170 lines, single-pass entry); (b)00f824f2-v2 修 图床 (加 2 张 Wiki.js 自带图); (c)a4fa5a32-v3 补 Fig 1 (3 张图全) — Fig 1 is the "类器官共培养模型" 概念图 (Robin 8-16 实战反思: 综述类概念图通常较小, 提取阈值要从 0KB 起步全收, 再按 caption 关联; 之前 >200KB 过滤漏了 Fig 1). The "与我们的产品" table on the paper lists CelVivo ClinoStar ⭐⭐⭐⭐ (临床转化类 器官的伦理合规——本文 7 大要点直接适用于 ClinoStar 客户 IRB 申请; Robin 推广 ClinoStar 给三甲医院时, 可附带本框架作为增值) + Mimetas OrganoPlate ⭐⭐⭐⭐ (类器官共培养芯片的伦理审查依据—— Mimetas 主打"类器官 + 免疫细胞共培养", 本文主题 B 的共培养伦理 框架直接适用) + Emulate Organ-Chip ⭐⭐⭐ (类器官 + 微流控 芯片的跨境监管参考).
The 2026-08-12 cluster is a single-paper LDR cycle on
Liang Y et al. (2026) Sci Rep DOI 10.1038/s41598-026-42990-2 — a
mouse liver organoid platform paper from 澳门科技大学 + 香港大学 that
establishes: (i) single-tissue 3-轨道 (Hep-Orgs + Cho-Orgs + HSC)
separation; (ii) DAPT (Notch 抑制) + Dexamethasone for P1-P10 长程
稳定成熟 (ALB / PAS / LDL / CYP all stable across 10 passages — single
DAPT only sustains P5); (iii) TGFβ 5-7 day activation of qHSC → aHSC
(Acta2 / Col1a1 上调); (iv) aHSC 共培养诱导 Hep-Orgs EMT
(Snail / Twist / Vimentin ↑; ALB / CK8 ↓; Lgr5 / EpCAM ↓; Ki67 ↓) =
体外肝纤维化模型. The 4 commits are the same single file
04-Literature/Deep-Reads/Liver/2026-08-12_Liang_2026_SciRep_liver_organoid_fibrosis_platform.md
walked through Robin's standard 3-stage SOP cycle: (a) e542c977
adds the file (186 lines, single-pass entry); (b) 8699a154 rewrites
the same file to the page 946 9 项 SOP 标杆 (105+/122- lines, adding
the 6 核心发现 三段式 tables + 6 SeaFile Fig + "与我们的产品" 4-star
table + 4-paper 参考文献 + 转发语 + 完整落款 + SeaFile PDF link); (c)
aacba7aa + 297f106d are the page 934 修齐 micro-revisions
(frontmatter title 改中文 / H1 去括号 / 元数据用 bold 单行 / 📄PDF
文件名 with actual filename) — the same alignment Robin applied across
the 2026-08-11 OVB-类器官 cycle. The "与我们的产品" 4-star table
on the paper lists CelVivo ClinoStar ⭐⭐⭐⭐ (P1-P10 长程扩增对应
旋转培养 30+ 天无剪切; HSC 静止态在模拟微重力下 7+ 天维持) +
CelVivo ClinoReactor ⭐⭐⭐⭐ (单组织 3 轨道分通道灌流; TGFβ 时间程序
精确切换) + CelVivo PhaseHolographic 成像 ⭐⭐⭐ + 3Brain HD-MEA ⭐⭐⭐
(肝-神经互作延伸).
No new vault commits landed in the 2026-08-12T18:08Z →
2026-08-13T18:08Z window — the vault HEAD is unchanged at
297f106d. The 2026-08-12 Liang 2026 cluster remains the most recent
committed vault activity. One new uncommitted file appeared in the
working tree this fetch:
04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md
— the first entry in a new Review/ subfolder (see the
Notable-entity section below).
7 new vault commits landed in the 2026-08-15T18:07Z →
2026-08-17T18:09Z window — the vault HEAD bumped from 297f106d
to a4fa5a32. The two 2026-08-16 LDR cycles (Quintard 2024
microfluidic organ-on-chip + Guo 2026 organoid ethics systematic
review) are the first time since the 2026-07-28 / 2026-07-29
Parate / Lee / Hodge cluster that two new paper deep-reads landed
on main in the same 48-hour window. The 2026-08-16 cluster
replaces the 2026-08-12 Liang 2026 cluster as the most recent
committed vault activity. Two new untracked directories appeared in
the working tree this fetch: celvivo_commercial/1331651_20260630_131201.pdf
(the 6-30 quote PDF migrated into a new folder) + templates/类器官IRB申请清单.md
(the IRB application checklist derived from Guo 2026 — Robin's first
customer-facing sales ammunition template produced from a single
deep-read; see the Notable-entity section below for synthesis).
The 2026-08-10 cluster is a frontmatter-hygiene + MOC-discipline
sprint rather than new external evidence: (a) Phase A batch
(d97b39ed) standardized 6 deep-read notes with the structured 6-field
frontmatter (doi / journal / year / volume / pages /
authors array / pmid) that the prior notes had been missing; (b)
方案 2 样品 (3b929c2f) added 7 image alt descriptions on top of the
6-field frontmatter for wang2024-org-on-chip.md; (c) MOC 方案 1
样品 (6b717aef) created Robin's first Map-of-Content file
(04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md, 95 lines, 沙牛《AI
时代的 Obsidian 公开课》课时 1 pattern) and added related: back-link
frontmatter to 7 papers. The MOC's own related: list already names
the next planned MOC — [[MOC-3Brain-HD-MEA]] — plus
[[02-Clients/Agents/_known_associations]] and
[[02-Active-Deals/CellShot-TriArm-Demo-计划-v2-老师版-2026-07-20]],
so the MOC pattern is expected to extend.
The 2026-08-08 cluster (prior manifest) was the literature
flywheel-sync output (Liu 2026, Miao 2025 v2, Sharma 2026) — already
indexed on /sources/literature.md. The
2026-08-07 / 2026-08-08 micro-revisions on Liu 2026 (a69ad9c4 →
1614ccf9) are the 8-step SOP rewrite cycle (v3 → v11) Robin re-ran
on the same paper.
openwiki-wiki — working-tree status (2026-08-24)
- Branch:
main - HEAD:
127c2dc(thechore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-24)commit). The 2026-08-24T18:05Z fetch observed wiki HEAD bumped froma9568d8(2026-08-23T18:11Z fetch) to127c2dc— 2 new automated wiki commits in the 2026-08-23T18:11Z → 2026-08-24T18:05Z 24-hour window: (a)9cc5e63chore: daily update 2026-08-24 (2026-08-24 02:23 +0800); (b)127c2dcchore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-24, 2026-08-24 02:30 +0800). Both commits are routine auto-orchestration — the9cc5e63daily update carried the synthesis-layer edits from the prior HN-1 2026-08-23T18:00Z + web-search-1 2026-08-23 (skipped) + git-repo-1 2026-08-23T18:11Z runs; the127c2dcsources-sync re-applied the count-data wipe pattern on NocoDB / SeaFile / Wiki.js / RAGFlow for the tenth consecutive time (after997b6482026-08-16 +be492852026-08-171fc73ae2026-08-18 +dcb53a22026-08-19 +bd303392026-08-20f6c25762026-08-21 +43d45482026-08-22 +8f8f7672026-08-23- now
127c2dc2026-08-24).
- Working-tree state: 6 modified files (uncommitted — pending
next CLI orchestration). The 2026-08-23T18:11Z fetch observed the
working tree at 6 uncommitted files (down from 9 at the
2026-08-22T18:13Z fetch because the
a9568d82026-08-23 daily update committed 6 of the prior 9 dirty files —sources/git-repo.mdsources/index.md+sources/nocodb.md+sources/ragflow.mdsources/seafile.md+sources/wikijs.md+themes/05-robin-research.mdpergit show --stat a9568d8— leaving 6 files re-modified by this git-repo-1 2026-08-23T18:11Z run). The 6 dirty files at this fetch are:
.last-update.json— CLI metadata, will be updated when this run'sstatus: completelands.quickstart.md— contains the accumulated "Latest update" paragraphs from the prior HN-1 2026-08-15 + web-search-1 2026-08-15- git-repo-1 2026-08-13 runs, plus the "Latest update —
git-repo-1 (2026-08-15T18:07Z)" + "Latest update — git-repo-1
(2026-08-17T18:09Z)" + "Latest update — git-repo-1
(2026-08-18T18:10Z)" + "Latest update — git-repo-1
(2026-08-19T18:08Z)" + "Latest update — git-repo-1
(2026-08-20T18:09Z)" + "Latest update — git-repo-1
(2026-08-21T18:09Z)" + "Latest update — git-repo-1
(2026-08-22T18:13Z)" paragraphs added by the 2026-08-15 +
2026-08-17 + 2026-08-18 + 2026-08-19 + 2026-08-20 + 2026-08-21 +
2026-08-22 git-repo runs + the "Latest update — web-search-1
attempted 2026-08-23 skipped" paragraph from the 2026-08-23
web-search-1 run; this git-repo-1 2026-08-23T18:11Z run adds the
"Latest update — git-repo-1 (2026-08-23T18:11Z)" paragraph and
updates the Backlog git-repo entry to reflect the new wiki HEAD
a9568d8.
- git-repo-1 2026-08-13 runs, plus the "Latest update —
git-repo-1 (2026-08-15T18:07Z)" + "Latest update — git-repo-1
(2026-08-17T18:09Z)" + "Latest update — git-repo-1
(2026-08-18T18:10Z)" + "Latest update — git-repo-1
(2026-08-19T18:08Z)" + "Latest update — git-repo-1
(2026-08-20T18:09Z)" + "Latest update — git-repo-1
(2026-08-21T18:09Z)" + "Latest update — git-repo-1
(2026-08-22T18:13Z)" paragraphs added by the 2026-08-15 +
2026-08-17 + 2026-08-18 + 2026-08-19 + 2026-08-20 + 2026-08-21 +
2026-08-22 git-repo runs + the "Latest update — web-search-1
attempted 2026-08-23 skipped" paragraph from the 2026-08-23
web-search-1 run; this git-repo-1 2026-08-23T18:11Z run adds the
"Latest update — git-repo-1 (2026-08-23T18:11Z)" paragraph and
updates the Backlog git-repo entry to reflect the new wiki HEAD
sources/README.md— refreshed connector-roll table row for web-search-1 (added the 2026-08-15 + 2026-08-17 + 2026-08-18 + 2026-08-19 + 2026-08-20 + 2026-08-21 + 2026-08-22 + 2026-08-23 skips to the 12-entry skip streak) + refreshed Active connectors Git repo row in this run.sources/hackernews.md— accumulated "Latest update — 2026-08-15 18:00 UTC" + "Latest update — 2026-08-16 18:00 UTC" + "Latest update — 2026-08-17 18:00 UTC" + "Latest update — 2026-08-18 18:00 UTC" + "Latest update — 2026-08-19 18:00 UTC"- "Latest update — 2026-08-20 18:00 UTC" + "Latest update — 2026-08-21 18:00 UTC" + "Latest update — 2026-08-22 18:00 UTC" sections from the prior HN-1 runs (Auto-research with codex 232x Faster Kernel + Anthropic multi-agent + Stripe/OpenRouter + Copilot Autofix + Qwen 3.8 27B + Agent Mesh + machine0 YC S26 + Amazon order emails AI-agent data + OpenRouter-Stripe formal confirmation + OneCLI + Extensible Software + Frugal Tokens + the Nature brain organoid time-passage paper + Anthropic Claude Code AGENTS.md feature request + Unsloth Dynamic 3.0 GGUFs + DeepSeek-v4-flash-vision-exp + Show HN Proliferate + self-hosted sandboxed agentic software factory + GitHub August 17 outage post-mortem + LiteLLM hiring + Munder Difflin agent-harness + New MCP Roadmap + Anthropic Claude Code reduced-effort A/B test
- Dullien maturation essay + Embedded AI book flag-for-traceability callouts + the 4th / 5th / 6th / 7th / 8th / 9th / 10th / 11th consecutive empty / noise-only Algolia lane streak notes) — landed in uncommitted state during the HN-1 runs.
sources/openwiki-version-drift.md— auto-generated page that tracks OpenWiki installed-vs-npm-latest version drift; was created in the 2026-08-17 daily update5c70881and the body re-touch on each subsequent daily update has kept the file in the working-tree dirty set across the 2026-08-18 + 2026-08-19 + 2026-08-20 + 2026-08-21 + 2026-08-22 daily update cycles; the file is small (one inline drift-table) and the re-touch on each cycle is the auto-generated timestamp bump; re-appears as dirty after thea9568d82026-08-23 daily update because the very next synthesis edits from this git-repo-1 2026-08-23T18:11Z run re-touch the file (refresh of the timestamp).sources/web-search.md— accumulated "2026-08-15 attempted update — skipped" + "2026-08-17 attempted update — skipped" + "2026-08-18 attempted update — skipped" + "2026-08-19 attempted update — skipped" + "2026-08-20 attempted update — skipped" + "2026-08-21 attempted update — skipped" + "2026-08-22 attempted update — skipped" + "2026-08-23 attempted update — skipped" sections from the web-search-1 2026-08-15 + web-search-1 2026-08-17 + web-search-1 2026-08-18 + web-search-1 2026-08-19 + web-search-1 2026-08-20 + web-search-1 2026-08-21 + web-search-1 2026-08-22 + web-search-1 2026-08-23 runs (5th + 6th + 7th + 8th- 9th + 10th + 11th + 12th consecutive skips on the same code path).
- Auth: local path only — no remote, no credentials.
- New file in this window:
sources/openwiki-version-drift.mdwas created in the 2026-08-17 daily update commit5c70881(auto- generated page that tracks OpenWiki installed-vs-npm-latest version drift; reports v0.3.1 local → v0.3.3 npm latest as of 2026-08-15T20:00:03Z; the page sits on the wiki to surface the drift without an external daemon). - Auth: local path only — no remote, no credentials.
Recent commits (latest first)
| Date | Hash | Note |
|---|---|---|
| 2026-08-25 | 1003b92 |
chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-25) — count-data wipe re-applied for the eleventh consecutive sources-sync (after 2026-08-15 2507925 + 2026-08-16 997b648 + 2026-08-17 be49285 + 2026-08-18 1fc73ae + 2026-08-19 dcb53a2 + 2026-08-20 bd30339 + 2026-08-21 f6c2576 + 2026-08-22 43d4548 + 2026-08-23 8f8f767 + 2026-08-24 127c2dc); see Notable-entity § "2026-08-15 sources-sync bug" |
| 2026-08-25 | 3255613 |
chore: daily update 2026-08-25 (synthesis-layer edits accumulated from the prior HN-1 2026-08-25T18:00Z + web-search-1 2026-08-25 (skipped) + git-repo-1 2026-08-25T18:13Z runs; committed 17 files from the prior dirty set per git show --stat 3255613 — including commitments.md + sources/git-repo.md + sources/hackernews.md + sources/index.md + sources/literature.md + sources/nocodb.md + sources/openwiki-version-drift.md + sources/ragflow.md + sources/seafile.md + sources/web-search.md + sources/wikijs.md + index.md + quickstart.md + sources/README.md + themes.md + themes/05-robin-research.md + themes/index.md; the very next synthesis edits from the git-repo-1 2026-08-25T18:13Z run re-touch the same files + add 2 newly dirty files per the manifest changedFiles list) |
| 2026-08-24 | 127c2dc |
chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-24) — count-data wipe re-applied for the tenth consecutive sources-sync (after 2026-08-15 2507925 + 2026-08-16 997b648 + 2026-08-17 be49285 + 2026-08-18 1fc73ae + 2026-08-19 dcb53a2 + 2026-08-20 bd30339 + 2026-08-21 f6c2576 + 2026-08-22 43d4548 + 2026-08-23 8f8f767); see Notable-entity § "2026-08-15 sources-sync bug" |
| 2026-08-23 | a9568d8 |
chore: daily update 2026-08-23 (synthesis-layer edits accumulated from the prior HN-1 2026-08-22T18:00Z + web-search-1 2026-08-22 (skipped) + web-search-1 2026-08-23 (skipped) + git-repo-1 2026-08-22T18:13Z runs; committed sources/git-repo.md + sources/index.md + sources/nocodb.md + sources/ragflow.md + sources/seafile.md + sources/wikijs.md + themes/05-robin-research.md from the prior dirty set, reducing uncommitted-file count from 9 → 6) |
| 2026-08-23 | 8f8f767 |
chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-23) — count-data wipe re-applied for the ninth consecutive sources-sync (after 2026-08-15 2507925 + 2026-08-16 997b648 + 2026-08-17 be49285 + 2026-08-18 1fc73ae + 2026-08-19 dcb53a2 + 2026-08-20 bd30339 + 2026-08-21 f6c2576 + 2026-08-22 43d4548); see Notable-entity § "2026-08-15 sources-sync bug" |
| 2026-08-22 | 43d4548 |
chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-22) — count-data wipe re-applied for the eighth consecutive sources-sync (after 2026-08-15 2507925 + 2026-08-16 997b648 + 2026-08-17 be49285 + 2026-08-18 1fc73ae + 2026-08-19 dcb53a2 + 2026-08-20 bd30339 + 2026-08-21 f6c2576); see Notable-entity § "2026-08-15 sources-sync bug" |
| 2026-08-22 | d8e2277 |
chore: daily update 2026-08-22 (synthesis-layer edits accumulated from the prior HN-1 2026-08-22T18:00Z + web-search-1 2026-08-22 (skipped) + git-repo-1 2026-08-21T18:09Z runs) |
| 2026-08-21 | f6c2576 |
chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-21) — count-data wipe re-applied for the seventh consecutive sources-sync (after 2026-08-15 2507925 + 2026-08-16 997b648 + 2026-08-17 be49285 + 2026-08-18 1fc73ae + 2026-08-19 dcb53a2 + 2026-08-20 bd30339); see Notable-entity § "2026-08-15 sources-sync bug" |
| 2026-08-21 | b6dc337 |
chore: daily update 2026-08-21 (synthesis-layer edits accumulated from the prior HN-1 2026-08-21T18:00Z + web-search-1 2026-08-21 (skipped) + git-repo-1 2026-08-20T18:09Z runs; committed sources/index.md from the 2026-08-20 dirty set) |
| 2026-08-20 | bd30339 |
chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-20) — count-data wipe re-applied for the sixth consecutive sources-sync (after 2026-08-15 2507925 + 2026-08-16 997b648 + 2026-08-17 be49285 + 2026-08-18 1fc73ae + 2026-08-19 dcb53a2); see Notable-entity § "2026-08-15 sources-sync bug" |
| 2026-08-20 | a44f284 |
chore: daily update 2026-08-20 (synthesis-layer edits accumulated from the prior HN-1 2026-08-20T18:00Z + web-search-1 2026-08-20 (skipped) + git-repo-1 2026-08-19T18:08Z runs) |
| 2026-08-19 | dcb53a2 |
chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-19) — count-data wipe re-applied for the fifth consecutive sources-sync (after 2026-08-15 2507925 + 2026-08-16 997b648 + 2026-08-17 be49285 + 2026-08-18 1fc73ae); see Notable-entity § "2026-08-15 sources-sync bug" |
| 2026-08-19 | 7e904ec |
chore: daily update 2026-08-19 (synthesis-layer edits accumulated from the prior HN-1 2026-08-19T18:00Z + web-search-1 2026-08-19 + git-repo-1 2026-08-18T18:10Z runs + the prior sources/openwiki-version-drift.md carryover) |
| 2026-08-18 | 1fc73ae |
chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-18) — count-data wipe re-applied for the fourth consecutive sources-sync (after 2026-08-15 2507925 + 2026-08-16 997b648 + 2026-08-17 be49285); see Notable-entity § "2026-08-15 sources-sync bug" |
| 2026-08-18 | 8127797 |
chore: daily update 2026-08-18 (synthesis-layer edits accumulated from the prior HN-1 2026-08-18T18:00Z + git-repo-1 2026-08-17T18:09Z runs + the new sources/openwiki-version-drift.md carryover) |
| 2026-08-17 | be49285 |
chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-17) |
| 2026-08-17 | 5c70881 |
chore: daily update 2026-08-17 (added sources/openwiki-version-drift.md auto-generated page + refreshed HN-1 / web-search-1 / git-repo-1 sections) |
| 2026-08-16 | 997b648 |
chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-16) |
| 2026-08-16 | 151d22b |
chore: daily update 2026-08-16 (committed sources/index.md from the 2026-08-15 dirty set; refreshed HN-1 / web-search-1 / git-repo-1 / themes/05-robin-research sections) |
| 2026-08-15 | 2507925 |
chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-15) — count-data wipe (NocoDB 6614 → 0, Wiki.js 83 → 0, RAGFlow landing 200 → 000); see Notable-entity § "2026-08-15 sources-sync bug" |
| 2026-08-15 | 173b58c |
chore: daily update 2026-08-15 (added OKF frontmatter to nocodb.md / ragflow.md / seafile.md / wikijs.md) |
| 2026-08-14 | 6258717 |
chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-14) |
| 2026-08-14 | 021e929 |
chore: daily update 2026-08-14 |
| 2026-08-13 | 1737454 |
chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-13) |
| 2026-08-13 | 8ddc6d9 |
chore: daily update 2026-08-13 (commitment + quickstart + sources/literature + sources/web-search + themes/01-organoid-equipment + themes/05-robin-research from the HN-1 2026-08-13 synthesis pass) |
| 2026-08-12 | c57ead4 |
chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-12) |
| 2026-08-12 | 431ee6a |
chore: daily update 2026-08-12 |
| 2026-08-11 | b64ae41 |
lit: PMID 41536916 Bioactive Materials AIVOs 综述 (Wiki.js 1711) |
| 2026-08-11 | 523ee7f |
lit: PMID 41686639 Cell Reports TNBC DEO + ROCK (Wiki.js 1710) |
| 2026-08-11 | 9be4f55 |
lit: PMID 41909700 Front Immunol 2026 类器官-小胶质细胞综述 (Wiki.js 1709) |
| 2026-08-11 | cc69ece |
lit: PMID 42041571 v4 - 按 literature-deep-read-research 9 项强制格式 |
| 2026-08-11 | b4bc8d9 |
lit: PMID 42041571 修正 - 真实PDF + 10张真图链接 |
| 2026-08-11 | 12480ab |
lit: 修正 wiki_url 到真实内网地址 |
| 2026-08-11 | cdc59c5 |
lit: PMID 42041571 OVB-organoids vs cerebral organoids Cells 2026 |
| 2026-08-11 | 2bcde39 |
chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-11) |
| 2026-08-11 | 7556e31 |
chore: daily update 2026-08-11 |
| 2026-08-09 | dde053a |
auto: 2026-08-09 Wang 2024 Theranostics OrgOC 综述精读入口 |
| 2026-08-09 | 3267338 |
chore: daily update 2026-08-09 |
| 2026-08-09 | 06f60e1 |
chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-09) |
| 2026-08-08 | c94940c7 |
feat: add Microbioreactor 2026 v4 (PMID 42516424, ID 1696) |
| 2026-08-08 | 7f65024 |
feat: add Microbioreactor 2026 v3 (PMID 42516424) |
| 2026-08-08 | ea4f14a |
feat: add Microbioreactor 2026 v2 (PMID 42516424) |
| 2026-08-08 | a193e46 |
feat: add Microbioreactor 2026 (PMID 42516424) deep-read entry |
| 2026-08-08 | bf90a91 |
fix: liu 2026 wiki link to main path |
| 2026-08-08 | cf1dbe0 |
fix: liu 2026 final link |
| 2026-08-08 | 26efd2f |
fix: liu 2026 v5 link |
| 2026-08-08 | e18993a |
fix: liu 2026 v4 link |
| 2026-08-08 | b206bd9 |
fix: liu 2026 v3 link |
| 2026-08-08 | c26dbdf |
fix: liu 2026 wiki link to v2 |
| 2026-08-08 | 703c3d4 |
literature: liu 2026 NBME shape-conformal organoid |
| 2026-08-08 | 1b78735 |
literature: miao 2025 cell v2 |
| 2026-08-08 | 5adc406 |
chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-08) |
| 2026-08-08 | 037c5f3 |
lit: add Sharma K 2026 Cell Stem Cell vRO retinal organoid (PMID 41529691) |
| 2026-08-07 | 9e80977 |
feat(openwiki): complete data flywheel activation (2026-08-07) |
| 2026-08-07 | 45af5a4 |
chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-07) |
| 2026-08-07 | bcd4a4f |
chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-07) |
| 2026-08-07 | 0bbef0f |
feat(openwiki v0.3.1 --update): generate themes 4-5 + index.md + themes/ + sources/ index (2026-08-07) |
| 2026-08-07 | 285c53b |
feat(openwiki v0.3.1): add YAML frontmatter + install-id markers from initial init run (2026-08-07) |
| 2026-07-24 | 3102e96 |
feat(sources): 全国 261 家经销商地图 (2026-07-24, 不含敏感信息) |
The wiki repo is the OpenWiki output itself — it persists across
update runs. 4 new wiki-side commits landed in the
2026-08-13T18:08Z → 2026-08-15T18:07Z window: (a) 021e929
(2026-08-14 +0800 02:18, chore: daily update 2026-08-14); (b)
6258717 (2026-08-14 +0800 02:30, chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-14));
(c) 173b58c (2026-08-15 +0800 02:00, chore: daily update 2026-08-15
— added OKF frontmatter to nocodb.md / ragflow.md / seafile.md /
wikijs.md); (d) 2507925 (2026-08-15 +0800 02:31, chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-15) — count-data wipe carried into the source pages; see
Notable-entity § "2026-08-15 sources-sync bug" below). Between these 4
commits, the wiki HEAD advanced from 1737454 (2026-08-13
sources-sync) to 2507925 (2026-08-15 sources-sync). The 6 wiki commits
from 2026-08-11 / 2026-08-12 (7556e31 / 431ee6a daily +
2bcde39 / c57ead4 sources-sync + the 6 lit-PMID commits on
2026-08-11 + 2bc03f3 / 06f60e1 / 5adc406 / 3267338 /
dde053a from the 2026-08-08 / 2026-08-09 cluster) are all already in
2507925's ancestry. The Liang 2026 wiki sync has not yet landed
(the /sources/literature.md short row is in working tree only); the
next wiki commit should add a fuller Liang 2026 row when the synthesis
pipeline catches up.
Summary of last 48 hours
| Window (UTC) | Vault | Wiki |
|---|---|---|
| 2026-08-24T18:05:00Z → 2026-08-25T18:13:00Z | HEAD fb017e4f → 9d4767c7 (5 new commits: 089177a7 Tevonian 2026 Nat Commun 血管化肝 MPS + 583859a8 Yang 2026 Stem Cell Res Ther cardiac organoid review + 9aa2af4c Tevonian + Yang product-mapping retrofit + 5907cdfc Shen 2026 Chin Med J vascularized organoids review + 9d4767c7 Zhai 2026 Sci Adv 3D skin pemphigus — SECOND consecutive single-day 5-paper LDR burst; combined with the 2026-08-23/24 5-paper burst, 10 LDR papers in 48 hours = largest sustained 2-day research output in Robin's vault activity log; the cluster creates 3 new 04-Literature/Deep-Reads/ subfolders: Vascularized-Organoids/ (Tevonian + Shen) + Cardiac-Organoids/ (Yang) + Skin-Organoids/ (Zhai), expanding Robin's per-vendor / per-application-domain subfolder taxonomy from ~19 to ~22; the cluster includes the first post-publish vendor-mapping retrofit commit (9aa2af4c) — adding CelVivo/Cellink/Mimetas/3Brain/Femtobiomed product mapping + 净化 Robin mentions to Tevonian + Yang retroactively) |
HEAD 127c2dc → 1003b92 (2 new automated commits: 3255613 chore: daily update 2026-08-25 + 1003b92 chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-25, the eleventh consecutive sources-sync re-applying the 2507925 2026-08-15 count-data wipe pattern after 997b648 2026-08-16 + be49285 2026-08-17 + 1fc73ae 2026-08-18 + dcb53a2 2026-08-19 + bd30339 2026-08-20 + f6c2576 2026-08-21 + 43d4548 2026-08-22 + 8f8f767 2026-08-23 + 127c2dc 2026-08-24 + now 1003b92 2026-08-25); the 3255613 daily update committed 17 files per git show --stat 3255613 (including commitments.md + sources/git-repo.md + sources/hackernews.md + sources/index.md + sources/literature.md + sources/nocodb.md + sources/openwiki-version-drift.md + sources/ragflow.md + sources/seafile.md + sources/web-search.md + sources/wikijs.md + index.md + quickstart.md + sources/README.md + themes.md + themes/05-robin-research.md + themes/index.md); the manifest changedFiles shows 11 dirty wiki files this fetch — M .last-update.json + M index.md + M quickstart.md + M sources/README.md + M sources/git-repo.md + M sources/hackernews.md + M sources/literature.md + M sources/nocodb.md + M sources/ragflow.md + M sources/seafile.md + M sources/web-search.md + M sources/wikijs.md) |
| 2026-08-23T18:11:00Z → 2026-08-24T18:05:00Z | HEAD a4fa5a32 → fb017e4f (5 new commits: ad4abcde Ajongbolo 2025 Cells brain organoid review + 5f02489a Kim 2025 Nat Commun EGaIn 3D MEA + 40b357b8 Tian 2025 Nat Commun hiPSC epicardium mTOR + f2118a62 Aiello & Bagni 2025 biorxiv Rotating Chamber brain organoid CFD + fb017e4f CelVivo App Note 2026 ClinoStar vs orbital shaker head-to-head — largest single-day LDR burst since the 2026-07-29 Parate / Lee / Hodge cluster, breaks the 7-fetch vault silence streak that started after the 2026-08-16 Quintard + Guo cluster; all 5 are single-shot entries at obsidian-vault/04-Literature/Deep-Reads/ root (no v2/v3 SOP rewrite cycles this cluster); commit timestamps 07:50 → 16:39 +0800 across the 2026-08-24 day) |
HEAD a9568d8 → 127c2dc (2 new automated commits: 9cc5e63 chore: daily update 2026-08-24 + 127c2dc chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-24, the tenth consecutive sources-sync re-applying the 2507925 2026-08-15 count-data wipe pattern after 997b648 2026-08-16 + be49285 2026-08-17 + 1fc73ae 2026-08-18 + dcb53a2 2026-08-19 + bd30339 2026-08-20 + f6c2576 2026-08-21 + 43d4548 2026-08-22 + 8f8f767 2026-08-23 + now 127c2dc 2026-08-24) + the prior a9568d8 2026-08-23 daily update was committed in this fetch's prior daily update cycle before the 5-paper burst landed; 9cc5e63 committed sources/git-repo.md + sources/hackernews.md + sources/index.md + sources/openwiki-version-drift.md + sources/web-search.md + themes/05-robin-research.md from the prior dirty set; the manifest changedFiles shows 8 dirty files this fetch — M .last-update.json + M sources/hackernews.md + M sources/literature.md + M sources/nocodb.md + M sources/ragflow.md + M sources/seafile.md + M sources/web-search.md + M sources/wikijs.md) |
| 2026-08-15T18:07:49Z → 2026-08-17T18:09:32Z | HEAD 297f106d → a4fa5a32 (7 new commits: 0fc8db24 + 290e9635 + 24c713de + 4073abf4 Quintard 2024 Nat Commun microfluidic vascularized organoid chip 4-commit LDR cycle + 2e6f5989 + 00f824f2 + a4fa5a32 Guo 2026 Front Cell Dev Biol organoid ethics systematic review 3-commit LDR cycle — first time since the 2026-07-28 / 2026-07-29 Parate / Lee / Hodge cluster that two new paper deep-reads landed on main in the same 48-hour window) |
HEAD 2507925 → be49285 (4 new commits: 151d22b daily update 2026-08-16 + 997b648 sources-sync 2026-08-16 + 5c70881 daily update 2026-08-17 + be49285 sources-sync 2026-08-17) |
| 2026-08-17T18:09:32Z → 2026-08-18T18:10:12Z | HEAD unchanged at a4fa5a32 (0 new commits, 0 new mtime changes — vault is silent in this 24-hour window; the 2026-08-16 Quintard 2024 + Guo 2026 cluster remains the most recent vault activity) |
HEAD be49285 → 1fc73ae (2 new automated commits: 8127797 chore: daily update 2026-08-18 + 1fc73ae chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-18, the fourth consecutive sources-sync re-applying the 2507925 2026-08-15 count-data wipe pattern)) |
| 2026-08-19T18:08:24Z → 2026-08-20T18:09:15Z | HEAD unchanged at a4fa5a32 (0 new commits, 0 new mtime changes — vault is silent in this 24-hour window for the 4th consecutive fetch; the 2026-08-16 Quintard 2024 + Guo 2026 cluster remains the most recent vault activity, 4 calendar days stale) |
HEAD dcb53a2 → bd30339 (2 new automated commits: a44f284 chore: daily update 2026-08-20 + bd30339 chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-20, the sixth consecutive sources-sync re-applying the 2507925 2026-08-15 count-data wipe pattern after 997b648 2026-08-16 + be49285 2026-08-17 + 1fc73ae 2026-08-18 + dcb53a2 2026-08-19 + now bd30339 2026-08-20)) |
| 2026-08-18T18:10:12Z → 2026-08-19T18:08:24Z | HEAD unchanged at a4fa5a32 (0 new commits, 0 new mtime changes — vault is silent in this 24-hour window for the 3rd consecutive fetch; the 2026-08-16 Quintard 2024 + Guo 2026 cluster remains the most recent vault activity, 3 calendar days stale) |
HEAD 1fc73ae → dcb53a2 (2 new automated commits: 7e904ec chore: daily update 2026-08-19 + dcb53a2 chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-19, the fifth consecutive sources-sync re-applying the 2507925 2026-08-15 count-data wipe pattern after 997b648 2026-08-16 + be49285 2026-08-17 + 1fc73ae 2026-08-18 + now dcb53a2 2026-08-19)) |
| 2026-08-20T18:09:15Z → 2026-08-21T18:09:00Z | HEAD unchanged at a4fa5a32 (0 new commits, 0 new mtime changes — vault is silent in this 24-hour window for the 5th consecutive fetch; the 2026-08-16 Quintard 2024 + Guo 2026 cluster remains the most recent vault activity, 5 calendar days stale) |
HEAD bd30339 → f6c2576 (2 new automated commits: b6dc337 chore: daily update 2026-08-21 + f6c2576 chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-21, the seventh consecutive sources-sync re-applying the 2507925 2026-08-15 count-data wipe pattern after 997b648 2026-08-16 + be49285 2026-08-17 + 1fc73ae 2026-08-18 + dcb53a2 2026-08-19 + bd30339 2026-08-20 + now f6c2576 2026-08-21)) |
| 2026-08-21T18:09:00Z → 2026-08-22T18:13:00Z | HEAD unchanged at a4fa5a32 (0 new commits, 0 new mtime changes — vault is silent in this 24-hour window for the 6th consecutive fetch; the 2026-08-16 Quintard 2024 + Guo 2026 cluster remains the most recent vault activity, 6 calendar days stale) |
HEAD f6c2576 → 43d4548 (2 new automated commits: d8e2277 chore: daily update 2026-08-22 + 43d4548 chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-22, the eighth consecutive sources-sync re-applying the 2507925 2026-08-15 count-data wipe pattern after 997b648 2026-08-16 + be49285 2026-08-17 + 1fc73ae 2026-08-18 + dcb53a2 2026-08-19 + bd30339 2026-08-20 + f6c2576 2026-08-21 + now 43d4548 2026-08-22)) |
| 2026-08-22T18:13:00Z → 2026-08-23T18:11:00Z | HEAD unchanged at a4fa5a32 (0 new commits, 0 new mtime changes — vault is silent in this 24-hour window for the 7th consecutive fetch; the 2026-08-16 Quintard 2024 + Guo 2026 cluster remains the most recent vault activity, 7 calendar days stale) |
HEAD 43d4548 → a9568d8 (2 new automated commits: 8f8f767 chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-23, the ninth consecutive sources-sync re-applying the 2507925 2026-08-15 count-data wipe pattern after 997b648 2026-08-16 + be49285 2026-08-17 + 1fc73ae 2026-08-18 + dcb53a2 2026-08-19 + bd30339 2026-08-20 + f6c2576 2026-08-21 + 43d4548 2026-08-22 + now 8f8f767 2026-08-23) + a9568d8 chore: daily update 2026-08-23 (carried the synthesis-layer edits from the prior HN-1 2026-08-22T18:00Z + web-search-1 2026-08-22 (skipped) + web-search-1 2026-08-23 (skipped) + git-repo-1 2026-08-22T18:13Z runs; committed 7 of the prior 9 dirty files — sources/git-repo.md + sources/index.md + sources/nocodb.md + sources/ragflow.md + sources/seafile.md + sources/wikijs.md + themes/05-robin-research.md — reducing uncommitted-file count from 9 → 6; the very next synthesis edits from this git-repo-1 2026-08-23T18:11Z run re-touch the remaining 6 files + 1 newly dirty sources/openwiki-version-drift.md)) |
| Net new external evidence | 2 new paper deep-reads (from the 2026-08-15T18:07Z → 2026-08-17T18:09Z window): Quintard 2024 Nat Commun microfluidic vascularized organoid chip + Guo 2026 Front Cell Dev Biol organoid ethics systematic review. 2 new untracked directories (from the same window): celvivo_commercial/1331651_20260630_131201.pdf (the 6-30 quote PDF migrated into a new folder) + templates/类器官IRB申请清单.md (the IRB application checklist derived from Guo 2026 — Robin's first customer-facing sales ammunition template produced from a single deep-read). The Review/zhou2023_computer_vision_microfluidics.md first-entry-in-Review/-subfolder is still untracked, carrying forward from the 2026-08-13 fetch (11-day carry-forward at the 2026-08-22T18:13Z fetch — was 10-day at the 2026-08-21T18:09Z fetch — was 9-day at the 2026-08-20T18:09Z fetch). No new vault evidence in the 2026-08-21T18:09Z → 2026-08-22T18:13Z 24-hour window |
1 new wiki file (from the 2026-08-17 daily update 5c70881): sources/openwiki-version-drift.md (auto-generated OpenWiki version-drift monitor; v0.3.1 local → v0.3.3 npm latest as of 2026-08-15T20:00:03Z). Wiki-side: the 2026-08-22T18:13Z fetch observed wiki HEAD bump f6c2576 → 43d4548 — 2 new automated wiki commits (d8e2277 daily update 2026-08-22 + 43d4548 sources-sync 2026-08-22 — the eighth consecutive sources-sync re-applying the 2507925 2026-08-15 count-data wipe pattern). Synthesis-layer edits accumulated across the prior HN-1 2026-08-13 + HN-1 2026-08-15 + HN-1 2026-08-16 + HN-1 2026-08-17 + HN-1 2026-08-18 + HN-1 2026-08-19 + HN-1 2026-08-20 + HN-1 2026-08-21 + HN-1 2026-08-22 + web-search-1 2026-08-15 + web-search-1 2026-08-17 + web-search-1 2026-08-18 + web-search-1 2026-08-19 + web-search-1 2026-08-20 (skipped) + web-search-1 2026-08-21 (skipped) + web-search-1 2026-08-22 (skipped) + git-repo-1 2026-08-13 + git-repo-1 2026-08-15 + git-repo-1 2026-08-17 + git-repo-1 2026-08-18 + git-repo-1 2026-08-19 + git-repo-1 2026-08-20 + git-repo-1 2026-08-21 + this git-repo-1 2026-08-22 runs are pending the next CLI commit cycle |
| Untracked → committed migrations | Quintard 2024 file (4 commits) + Guo 2026 file (3 commits) all moved from absent → committed on main (in the 2026-08-15T18:07Z → 2026-08-17T18:09Z window); the 2 new untracked directories are net-new in the same window. None in the 2026-08-17T18:09Z → 2026-08-18T18:10Z 24-hour window (vault silent) or the 2026-08-18T18:10Z → 2026-08-19T18:08Z 24-hour window (vault silent for the 3rd consecutive fetch) or the 2026-08-19T18:08Z → 2026-08-20T18:09Z 24-hour window (vault silent for the 4th consecutive fetch) or the 2026-08-20T18:09Z → 2026-08-21T18:09Z 24-hour window (vault silent for the 5th consecutive fetch) or the 2026-08-21T18:09Z → 2026-08-22T18:13Z 24-hour window (vault silent for the 6th consecutive fetch). |
2026-08-15T18:07Z → 2026-08-17T18:09Z window: the sources/index.md from the 2026-08-15 dirty set was committed by the 2026-08-16 daily update 151d22b; the remaining 9 dirty files are uncommitted synthesis edits accumulated across the prior HN-1 + web-search-1 + git-repo-1 runs. 2026-08-17T18:09Z → 2026-08-18T18:10Z window: the 8127797 2026-08-18 daily update committed a subset of the synthesis-layer edits from the prior HN-1 2026-08-18T18:00Z + git-repo-1 2026-08-17T18:09Z runs (touching commitments.md + index.md + quickstart.md + sources/{README,git-repo,hackernews,index,literature,nocodb,ragflow,seafile,web-search,wikijs}.md + themes/{01-organoid-equipment,05-robin-research}.md per git show --stat 8127797); the 9 dirty files re-appear in the working tree because the very next synthesis edits from this git-repo-1 2026-08-18T18:10Z run re-touch the same files. 2026-08-18T18:10Z → 2026-08-19T18:08Z window: the 7e904ec 2026-08-19 daily update committed a subset of the synthesis-layer edits from the prior HN-1 2026-08-19T18:00Z + web-search-1 2026-08-19 + git-repo-1 2026-08-18T18:10Z runs (touching .last-update.json + quickstart.md + sources/{README,git-repo,hackernews,index,nocodb,ragflow,seafile,web-search,wikijs}.md + themes/05-robin-research.md per git show --stat 7e904ec); the 10 dirty files (.last-update.json + quickstart.md + sources/{README,hackernews,index,nocodb,ragflow,seafile,web-search,wikijs}.md) re-appear in the working tree because the very next synthesis edits from this git-repo-1 2026-08-19T18:08Z run re-touch the same files. 2026-08-19T18:08Z → 2026-08-20T18:09Z window: the a44f284 2026-08-20 daily update committed a subset of the synthesis-layer edits from the prior HN-1 2026-08-20T18:00Z + web-search-1 2026-08-20 (skipped) + git-repo-1 2026-08-19T18:08Z runs; the 10 dirty files re-appear in the working tree because the very next synthesis edits from this git-repo-1 2026-08-20T18:09Z run re-touch the same files. 2026-08-20T18:09Z → 2026-08-21T18:09Z window: the b6dc337 2026-08-21 daily update committed a subset of the synthesis-layer edits from the prior HN-1 2026-08-21T18:00Z + web-search-1 2026-08-21 (skipped) + git-repo-1 2026-08-20T18:09Z runs; sources/index.md was committed by b6dc337 (was re-appearing as dirty since 2026-08-16 daily update). The 9 dirty files (.last-update.json + quickstart.md + sources/{README,hackernews,nocodb,ragflow,seafile,web-search,wikijs}.md) re-appear in the working tree because the very next synthesis edits from this git-repo-1 2026-08-21T18:09Z run re-touch the same files. 2026-08-21T18:09Z → 2026-08-22T18:13Z window: the d8e2277 2026-08-22 daily update committed a subset of the synthesis-layer edits from the prior HN-1 2026-08-22T18:00Z + web-search-1 2026-08-22 (skipped) + git-repo-1 2026-08-21T18:09Z runs; the 9 dirty files (.last-update.json + quickstart.md + sources/{README,hackernews,nocodb,ragflow,seafile,web-search,wikijs}.md) re-appear in the working tree because the very next synthesis edits from this git-repo-1 2026-08-22T18:13Z run re-touch the same files. The 9 dirty files are awaiting the next CLI commit cycle |
| Operational issue carried over from prior runs | n/a | 2507925 2026-08-15 sources-sync bug + the 2026-08-16 997b648 + 2026-08-17 be49285 + 2026-08-18 1fc73ae + 2026-08-19 dcb53a2 + 2026-08-20 bd30339 + 2026-08-21 f6c2576 + 2026-08-22 43d4548 sources-syncs (which re-applied the same operational pattern as 2507925 — NocoDB / Wiki.js / RAGFlow count values stayed zero across all 8 sources-syncs). The on-disk ~/.openwiki/connectors/web-search/config.json is unaffected — this is a wiki-side CRON issue with the auto-source-sync job, not a connector config issue. Recorded for traceability on /sources/git-repo.md Notable-entity § "2026-08-15 sources-sync bug" and on each affected /sources/{nocodb,ragflow,seafile,wikijs}.md page. The data is recoverable from git show 8ddc6d9:sources/nocodb.md etc. for any future recovery commit |
Vault navigation index
The vault uses a numbered top-level layout. Scripts, caches, and temp*
working folders are excluded from this index.
| Dir | Purpose | Size hint |
|---|---|---|
01-Active-Sales/ |
Active sales pipeline files (board + per-account) | 6 .md |
02-Active-Deals/ |
Deal-level active docs | 1 .md |
02-Clients/, 02-Contacts/ |
Client & contact records | sparse |
03-Product/ |
Product briefs (e.g. 3Brain-Maxwell comparison) | 1 .md |
03-Resources/Agents/ |
Distributor / agent profiles | a handful |
03-Resources/End-Customers/ |
End-customer dossiers (3Brain MEA accounts, etc.) | 11+ .md |
03-Resources/ITX-24h-Host/ |
Personal 24h Hermes-Agent / AI-workflow host build config (2026-07-31 untracked; not yet on main) |
1 .md |
04-Literature/ |
Paper deep-reads + curated vendor PDFs | see breakdown |
05-Documents/Contracts/ |
Signed/pending contracts (Celvivo subfolder) | — |
05-Documents/Products/ |
Vendor-facing product docs (Celvivo/Industrial-Customers) | — |
05-Documents/{Proposals,Quotes,Visit-Plans}/ |
Active commercial docs | — |
05-Products/ |
In-house product briefs (MappingLab family) | 2 .md |
06-Sales/Competitors/ |
Competitor tracking | — |
06-Sales/Configurations/ |
Product configurations | — |
06-Sales/Content/{FAQ,Pain-Points,PPT-Scripts,Success-Stories,Training-Materials,推文模板}/ |
Sales content library | — |
06-Sales/{Price-List,Product-Mapping,Recommendation-Engine}/ |
Sales tooling | — |
99-Templates/ |
Reusable Obsidian templates | 14 .md |
memory/ |
Daily reports, weekly digests, .dreams, archive |
147 .md |
04-Literature/Deep-Reads/ breakdown
Markdown file counts per deep-read subfolder:
| Subfolder | .md count |
|---|---|
Organoid/ |
661 (+2 from 2026-08-16 — Quintard 2024 Nat Commun microfluidic vascularized organoid chip + Guo 2026 Front Cell Dev Biol organoid ethics systematic review) |
04-Literature/Deep-Reads/ root |
+5 new files on 2026-08-23 single-shot LDR burst — CelVivo_Shear_Stress_AppNote_2026 + Aiello_Bagni_2025_biorxiv_Brain_Organoid_Fluid + Tian_2025_NatCommun_Epicardium_mTOR + Kim_2025_NatCommun_Liquid_Metal_3D_MEA + Ajongbolo_2025_Cells_Brain_Organoids_Review (all in vault root, not in a per-vendor subfolder — this is a non-standard pattern vs the prior per-vendor subfolder discipline, see Notable-entity § "2026-08-23 root-level LDR burst") |
Celvivo/ |
142 |
3Brain/ |
136 |
Cellink/ |
129 |
Organoid-List/ |
51 |
Product-Reports/ |
38 |
Brain/ |
11 |
Brain-Tumor/ |
9 |
Cancer/ |
6 |
Liver/ |
6 |
Other/ |
6 |
RegenMed/ |
1 |
3Brain MEA/ |
3 |
Cardiac/ |
2 |
Kidney/ |
2 |
Retinal/ |
1 |
Microbioreactor/ |
1 (new as of 2026-08-07 — Rosero 2026 Front Bioeng Biotechnol) |
Cells/ |
1 (new as of 2026-08-08 — Fernandez Vallone 2026 Cells THSDC) |
Review/ |
1 (new as of 2026-08-13 — Zhou 2023 computer vision + microfluidics, untracked, 10-day carry-forward at 2026-08-21 fetch, 8 fetches silent — structural signal continuing to weaken; 11-day carry-forward at 2026-08-22 fetch, 9 fetches silent; 12-day carry-forward at 2026-08-23 fetch, 10 fetches silent; 13-day carry-forward at 2026-08-24 fetch, 11 fetches silent — structural signal continues to weaken; 14-day carry-forward at 2026-08-25 fetch, 12 fetches silent — structural signal continues to weaken, subfolder is more likely one-off than recurring) |
templates/ |
1 (new as of 2026-08-17 — 类器官IRB申请清单.md, derived from the Guo 2026 ethics deep-read; Robin's first customer-facing template produced from a single deep-read, untracked, 5-day carry-forward at 2026-08-21 fetch (was 4-day at 2026-08-20); 6-day carry-forward at 2026-08-22 fetch; 7-day carry-forward at 2026-08-23 fetch; 8-day carry-forward at 2026-08-24 fetch; 9-day carry-forward at 2026-08-25 fetch) |
celvivo_commercial/ |
1 (new as of 2026-08-17 — 1331651_20260630_131201.pdf, the 6-30 quote PDF migrated into a new folder, untracked, 5-day carry-forward at 2026-08-21 fetch (was 4-day at 2026-08-20); 6-day carry-forward at 2026-08-22 fetch; 7-day carry-forward at 2026-08-23 fetch; 8-day carry-forward at 2026-08-24 fetch; 9-day carry-forward at 2026-08-25 fetch) |
Vascularized-Organoids/ |
2 (new as of 2026-08-25 — Tevonian_2026_Nat_Commun_Vascularized_Liver_MPS.md + Shen_2026_Chin_Med_J_Vascularized_Organoids_Review.md; the prior per-vendor subfolder discipline returns after the 2026-08-23/24 root-level burst; subfolder semantics: vascularized organoid application-domain cluster) |
Cardiac-Organoids/ |
1 (new as of 2026-08-25 — Yang_2026_Stem_Cell_Res_Ther_Cardiac_Organoid_Review.md; expanded from the prior 2-file Cardiac/ subfolder into a dedicated Cardiac-Organoids subfolder — companion application-domain to the existing 2-paper Cardiac bucket) |
Skin-Organoids/ |
1 (new as of 2026-08-25 — Zhai_2026_Sci_Adv_3D_Skin_Pemphigus.md; net-new application domain (autoimmune dermatology + 3D skin) to Robin's deep-read set; companion to the existing Cardiac / Brain / Liver / Vascularized-Organoids / Cancer / Kidney / Retinal application-domain subfolders) |
Total ≈ 1,217 deep-read notes on main (+4 new LDR files from the 2026-08-24/25 cluster on top of +5 from the 2026-08-23/24 single-shot LDR burst and +2 from the 2026-08-16 Quintard 2024 + Guo 2026 clusters; the 5th 2026-08-25 commit 9aa2af4c is an in-place M touch on Tevonian + Yang files, not a new file). Robin's LDR cluster pattern is now 2 consecutive 5-commit windows (2026-08-23/24 + 2026-08-24/25), totalling 11 commits / 9 new files in 48 hours.
Review/ zhou2023 computer vision + microfluidics, untracked — only
counts once committed; +2 working-tree files in the new templates/ +
celvivo_commercial/ directories, both untracked; +1 working-tree directory deepread_40240593/ (7 subdirs, 2026-08-24) carrying pipeline intermediate artifacts from the 5-paper burst). The 2026-08-23/24 single-shot LDR burst (5 papers at vault root) is the most recent committed deep-read cluster; the 2026-08-16 Quintard 2024 + Guo 2026 cluster remains the prior committed cluster; the 2026-08-07 / 2026-08-08 cluster (Microbioreactor + Cells) remains the prior-prior committed cluster. CelVivo, 3Brain, Cellink, and the broad Organoid/ bucket cover Robin's product KB per the wiki goal focus areas (类器官培养与设备, 3D 生物打印). The new templates/ folder signals Robin may be formalizing customer-facing deliverables (checklists / templates / sales scripts) as a separate vault subtree — the IRB application checklist is the first such artifact.
Distributor map refresh (2026-08-07)
Robin uploaded a refreshed b7f52af896c1e3a9.xlsx on 2026-08-07 11:11,
producing 8 new *2026-0807.md regional files + a new
全国经销商地图-2026-0807.md index + a new product-association
index (_known_associations.md) + a new _meta.json reflecting the
259-dealer tally. The 2026-07-24 baseline (*2026-0724.md × 7 + index)
remains in the repo but is now stale.
What changed in the 2026-08-07 baseline vs the 2026-07-24 baseline:
| Dimension | 2026-07-24 (_meta.json) |
2026-08-07 (全国经销商地图-2026-0807.md) |
|---|---|---|
| Total dealers | 261 (明细表口径) | 259 (公司数量汇总) |
| xlsx sha256 | 3afd448edcf3a9673848da0de2c554e6a4b22d7329b988695ca242c8bc8c10cf |
(re-uploaded with 8-04 同名 + 新增 2-3 家) |
| Region table | 华北 74 / 华东 68 / 华南 62 / 山东 25 / 湖北 19 / 西北 6 / 西南 7 | 华北 72 / 华东 68 / 华南 62 / 山东 25 / 湖北 19 / 西北 6 / 西南 7 |
| 华北 count | 74 | 72 (-2) |
| Hook 4 output | (none) | 4 dealer-management hooks + _known_associations.md |
The numeric 261 vs 259 difference is still rooted in the 华北 表 74 vs
汇总 72 discrepancy (two unnamed companies — 序号 63 / 67 — leave the
明细表 2 rows above the 汇总表); the 2026-08-07 baseline carries the
same data anomaly plus a new structural artifact: 济南成全生物科技
(曹沛起) is registered in both 华北-2026-0807.md and 山东-2026-0807.md
(legitimate cross-region duplicate) — this is the only CelVivo
ClinoStar agent in the 259-dealer list and is the thread Robin should
follow to close the agent-dong-huiqun-celvivo open question.
_known_associations.md (2026-08-07) — product → dealer mapping
The new index file 02-Clients/Agents/_known_associations.md is the
canonical hook-4 output Robin needs to evaluate before the next
Chinese-region dealer visit. Key mappings surfaced (5 direct hits):
| Product line | 261-dealer表 命中 | 关联客户 / 商机 |
|---|---|---|
| CelVivo (ClinoStar / ClinoReactor) | 济南成全生物科技有限公司 (曹沛起) — registered in both 华北 + 山东 (cross-region, 2 次) | 董慧群关联 (待 Robin 确认是否同公司) |
| FemtoBiomed (CellShot / PROLIVA) | 0 direct hits (9X Bio / 汇佰生物 is the direct intermediate, not in the 261 dealer list) | TriArm Therapeutics (翁靖傑, 上海 CGT/CAR-T) — 128 万 Phase1 / 8-10 至 8-14 现场 demo |
| 3Brain (HD-MEA) | 0 direct hits | — |
| Cellink (BIO X) | 0 direct hits | — |
| 西南医大 心研所 殴贤红 | 2 dealers: 成都百乐 (杨军, 钻石级 1亿, Bio-Rad / Sartorius / Oxford Nanopore / Cytek / Leica, 覆盖川渝黔藏) + 成都立德赛 (川渝云贵陕) | (待 Robin 决策) |
Hook-4 questions (Robin 优先补全, per _known_associations.md):
- 董慧群 is which specific technical contact at 济南成全 — or is she at a different CelVivo-代理?
- 西南医大 殴贤红 → 成都百乐 vs 成都立德赛 — which dealer first?
- 邓昊伦 (02-Contacts/) 蛇类神经方向 → 3Brain HD-MEA 拜访?
- 261 dealer 表 has 0 3Brain / Cellink 代理 — is the dealer list incomplete, or does Robin need to actively recruit those dealers?
Log these as a new commitment on /commitments.md
(distributor-8-07-association-followup) and as updates to
/open-questions.md (the agent-dong-huiqun-celvivo question now
partially answered — agency identified but personal contact
fields still 待补).
Notable entities surfaced by the vault (structural hints only)
- 2026-08-23 root-level LDR burst (5 papers, single-shot entries, vault HEAD bump
a4fa5a32→fb017e4f) — largest single-day LDR cluster since the 2026-07-29 Parate / Lee / Hodge cluster; breaks the 7-fetch vault-silence streak that started after the 2026-08-16 Quintard + Guo cluster; all 5 files landed atobsidian-vault/04-Literature/Deep-Reads/root (not in a per-vendor subfolder) on 2026-08-23/24 between 07:50 +0800 and 16:39 +0800; non-standard pattern vs the prior per-vendor subfolder discipline (every prior LDR cluster since 2026-07-28 has sorted intoOrganoid//Celvivo//3Brain//Cells/etc.). The 5 commits are all single-shot entries (no v2/v3 SOP rewrite cycles this cluster, unlike the 2026-08-16 Quintard 4-commit + Guo 3-commit pattern). Commit timestamps2026-08-23(Western time) +2026-08-24(UTC mtime): (a)ad4abcde2026-08-24 feat: Ajongbolo 2025 Cells 脑类器官综述精读 (Wiki.js 1743) —Ajongbolo_2025_Cells_Brain_Organoids_Review.md, the canonical review paper of the cluster, 11,367 bytes; (b)5f02489a2026-08-24 feat: Kim 2025 NatCommun 液态金属 3D MEA 精读 (Wiki.js 1744) —Kim_2025_NatCommun_Liquid_Metal_3D_MEA.md, 13,567 bytes, the 3D-MEA competitor paper of the cluster; (c)40b357b82026-08-24 feat: Tian 2025 NatCommun 心外膜 mTOR 精读 (Wiki.js 1745) —Tian_2025_NatCommun_Epicardium_mTOR.md, 15,578 bytes, the cardiac-epicardium paper of the cluster; (d)f2118a622026-08-24 feat: Aiello & Bagni 2025 biorxiv Rotating Chamber brain organoid 精读 (Wiki.js 1746) —Aiello_Bagni_2025_biorxiv_Brain_Organoid_Fluid.md, 11,731 bytes, the CelVivo-KB-derived brain-organoid CFD paper of the cluster; (e)fb017e4f2026-08-24 feat: CelVivo App Note 2026 shear stress ClinoStar vs orbital shaker (Wiki.js 1747) —CelVivo_Shear_Stress_AppNote_2026.md, 10,145 bytes, the vendor App Note of the cluster. 3 of the 5 papers are CelVivo-aligned: the App Note (direct CelVivo document) + Aiello (CelVivo KB-sourced) + Ajongbolo review (mentions ClinoStar in the synthesis). 1 is a 3D-MEA competitor: Kim EGaIn magnetic-reshapable 3D MEA. 1 is a cardiac epicardium paper: Tian mTOR. The cluster anchors 4 of 5 to Robin's 4 vendor product lines (CelVivo=3, 3Brain-adjacent=1) plus 1 cardiac expansion. Synthesis routes into/themes/01-organoid-equipment.md(CelVivo evidence) +/themes/05-robin-research.md(vault-snapshot refresh + deep-reads breakdown) +/sources/literature.md(last-30-days table). Net-new external evidence in this run. Track on next fetch whether (a) more LDR files land in vault root (extending the root-level pattern) or migrate to per-vendor subfolders on next SOP revision, (b) thedeepread_40240593/pipeline workspace gets committed (per the Notable-entity entry below), (c) the existing MOC pattern at04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.mdgets a 2026-08-23/24 LDR-cycle entry. - CelVivo App Note 2026 shear stress ClinoStar vs orbital shaker (2026-08-23, single-shot LDR entry
fb017e4f, Wiki.js 1747) —obsidian-vault/04-Literature/Deep-Reads/CelVivo_Shear_Stress_AppNote_2026.md(10,145 bytes). Stougaard Borgen Løschenkohl + Sedighi Frandsen, CelVivo Application Note 2026, sourced from RAGFlow CelVivo KB (1555e5b2..., Robin 8-24 上传). The note establishes head-to-head comparison of ClinoStar® vs orbital shaker for 3D 类器官/球体培养 (HepG2/C3A 15-day + embedded Caco-2 肠 + brain organoid). Core findings: (i) low shear stress ClinoStar preserves cytoskeletal integrity — phalloidin/DAPI 染色 shows ClinoStar F-actin 排列规则 + 形态紧凑 + 细胞间内聚性强 vs orbital shaker F-actin 散布 + 形态松散 + 内聚性下降 (4x + 20x dual magnification); (ii) 15-day standardized workflow — same source cells (HepG2/C3A) + same pre-conditioning (SP5D 24孔球形板 Kugelmeiers, 1000 cells/aggregate) + same end-point assays (image + ATP + BCA + fluorescent staining + microscopy) + 3 bio-replicates per condition; (iii) multi-model transferability — embedded Caco-2 肠 + brain organoid both show ClinoStar advantage → vendor claim "low shear stress sensitive cell class (肝/肠/脑来源)" validated across 3 model systems. Net-new external evidence in this run (git-repo-1 2026-08-24). Highest commercial-relevance paper of the cluster: this is the canonical CelVivo vs-orbital-shaker competitive-killer document and is Robin's first vendor App Note deep-read (vs. 1 primary research paper + 1 review paper from prior clusters). Track on next fetch whether (a) Robin produces a deep-read synthesis page at/sources/literature-celvivo-shear-stress-appnote-2026-deepread.mdmirroring the prior pattern, (b) the App Note is folded into06-Sales/Content/Training-Materials/(the existing CelVivo赋能培训 v1-v9 cluster could absorb the head-to-head comparison data as a new PPT module), (c) the App Note spawns a new sales commitment similar to the existingcelvivo-clinoreactor-thewell-bioscience-xeno-freeitem. - Aiello & Bagni 2025 biorxiv Rotating Chamber brain organoid CFD (2026-08-23, single-shot LDR entry
f2118a62, Wiki.js 1746) —obsidian-vault/04-Literature/Deep-Reads/Aiello_Bagni_2025_biorxiv_Brain_Organoid_Fluid.md(11,731 bytes). Aiello F, Bagni C et al., biorxiv preprint (the EMBO Reports submission versionAiello_Bagni_EMBO R_050325), 2026-08-24 Robin 从 CelVivo KB 找到的 PDF. The paper is the first CFD-quantified Rotating Chamber (RC) low-shear-stress study in Robin's deep-read set: (i) RC geometry: outer Ø 78.3 mm × H 24.2 mm, inner cavity Ø 37.7 mm × H 8.8 mm (reserved for organoid growth space); (ii) COMSOL Multiphysics 6.2 CFD simulation shows cavity shear stress < 20 mPa (extremely low vs. standard stirred/shaken systems) — first quantitative number on RC shear-stress field; (iii) multi-density organoid shear-stress validation — relative density 1010/1020/1030 vs medium 1000 confirms shear-stress uniformity across density range + 0-300 objects all experience stable low shear; (iv) morphological consistency — multi-batch + multi-cell-line brain organoid cultures show CV < 15% (vs static culture CV > 30%); (v) cortical cell type recapitulation (SOX2/Nestin/PAX6 + DCX + TBR1/SATB2/MAP2 multi-marker IHC) + scRNA-seq OXPHOS metabolic profiling. Net-new external evidence in this run. Vendor-anchor mapping: Aiello paper is CelVivo ClinoStar-adjacent (uses RC system which is the ClinoStar simplified geometry) + 3Brain HD-MEA-adjacent (cortical organoid electrophysiology read-out). The < 20 mPa quantitative claim is direct ammunition for the existing ClinoStar ⭐⭐⭐⭐ vendor-positioning pitch — no prior paper in Robin's deep-read set provides the quantitative CFD number for ClinoStar's low-shear-stress value proposition. Track on next fetch whether Robin produces a deep-read synthesis page; the deep-read pipeline currently does not carry an Aiello synthesis page. - Tian 2025 Nat Commun hiPSC epicardium mTOR maturation (2026-08-23, single-shot LDR entry
40b357b8, Wiki.js 1745) —obsidian-vault/04-Literature/Deep-Reads/Tian_2025_NatCommun_Epicardium_mTOR.md(15,578 bytes, the largest of the 5 new LDR files). Tian Y, Lucena-Cacace A, Tani K et al., Nat Commun 2025, DOI 10.1038/s41467-025-60934-8. The paper establishes: (i) mTOR inhibition drives epicardium maturation — Torin1 (dual mTORC1/2 inhibitor, 200 nM) on mouse E12 embryonic heart explants upregulates WT1 (mature epicardium marker) + downregulates EMT markers (SNAI1/2) + downregulates cell cycle (MKI67/PCNA) + downregulates mTOR pathway; bulk RNA-seq PCA shows 28.53% (PC1) + 36.01% (PC2) variance explained = significant transcriptome shift toward adult epicardium identity; (ii) mTORC1/2 dual inhibition is critical — Rapamycin (single mTORC1) alone is insufficient; mTORC2 is the key node; (iii) hiPSC-derived epicardium maturation with Torin1 — qPCR validates mature markers (TJP1/WT1/TBX18/ALDH1A2/CDH18) up + EMT markers (SNAI1/SNAI2/CDH2/CDH1) down + proliferation markers (MKI67/PCNA/MCM2) down + fatty-acid metabolism maturation (PDK4/PPARGC1A/SIRT1/FASN/SREBF1); bulk RNA-seq with 379 DEGs; Torin1 vs adult epicardium GSE84085 heatmap confirms adult-like profile; YBX3 + MAFF identified as Torin1-specific TFs via Venn diagram + siRNA knockdown; (iv) paracrine effect on cardiomyocyte maturation — mature epicardium (Torin1-treated) co-cultured with hiPSC ventricular cardiomyocyte EBs for 10 days upregulates TNNI3 (adult cardiomyocyte marker) → epicardium-to-cardiomyocyte maturation cross-talk via paracrine signaling. Net-new external evidence in this run. Application domain: cardiac organoid regeneration; not directly anchored to CelVivo/3Brain/Cellink/Femtobiomed product lines (no vendor rating callouts in the deep-read) but fits the broad cardiac application-domain bucket that Robin's wiki scope covers. Track on next fetch whether (a) Robin produces a deep-read synthesis page, (b) the Tian paper routes into any commitment — there is no cardiac-specific commitment in/commitments.mdyet. - Kim 2025 Nat Commun EGaIn liquid-metal 3D MEA (2026-08-23, single-shot LDR entry
5f02489a, Wiki.js 1744) —obsidian-vault/04-Literature/Deep-Reads/Kim_2025_NatCommun_Liquid_Metal_3D_MEA.md(13,567 bytes). Kim E, Jeong E, Hong YM et al., Nat Commun 2025, DOI 10.1038/s41467-024-55752-3. The paper establishes: (i) EGaIn (eutectic gallium-indium) 3D pillar MEA — microfluidic direct-ink-writing fabrication with pillar height 25-310 μm controllable by printing speed (R² > 0.95, n=12 datapoints), pillar diameter down to 14 μm (single-neuron scale), parylene-C selective encapsulation with only pillar tip exposed as electrode; (ii) magnetically reshapable — Ni magnetic layer on pillar exterior + external magnetic field drives pillar bending → 3D MEA shape conforms to different organoid sizes/shapes (no fabrication re-spin needed); (iii) hPSC cortical organoid maturation timeline — Dorsomorphin + SB-431542 (dual-SMAD) → FGF2/EGF expansion → BDNF/NT3 maturation at 15/30/45/60/120 days; 30d SOX2+/TUJ1+ early neuronal; 60d SOX2↓ + TUJ1↑↑; 120d 6-marker co-expression (MAP2/GFAP/VGLUT1/SATB2/CTIP2) = cortical 6-layer-like structure; (iv) biocompatible integration — 4-month organoid seeded on 3D MEA, co-cultured 14 days; live/dead + qPCR (PAX6/Nestin/TUJ1) + IHC (Nestin/TUJ1/SOX2/MAP2/GFAP) all confirm biocompatibility; (v) single-unit spike + network synchronization recording — 64-channel MEA acquisition + SU spike detection + synchronization score + network graph analysis across 1/2/4/6 month organoid maturation. Net-new external evidence in this run. Vendor-anchor mapping: 3Brain HD-MEA competitor / adjacent paper — Kim's EGaIn 3D MEA is a next-generation flexible 3D MEA approach that is adjacent to but not directly competing with 3Brain's rigid Accura-3D chip (3Brain uses 4096-electrode planar CMOS, Kim uses 3D pillar EGaIn with magnetic reshape). The Liu 2026 NBME shape-conformal framework from the 2026-08-08 cluster is a third next-gen HD-MEA approach — 3 distinct next-gen HD-MEA approaches now in Robin's deep-read set: Liu 2026 Rogers Lab flexible-electronics framework (3000-8000 ch, >90% surface coverage) + Kim 2025 EGaIn 3D pillar (25-310 μm height, magnetic reshape) + Kim's pillar biocompatibility with cortical organoid (1/2/4/6-month maturation timeline). Track on next fetch whether (a) Robin produces a deep-read synthesis page at/sources/literature-kim-2025-nat-commun-liquid-metal-3d-mea-deepread.md, (b) the Kim paper routes into the existingliu-2026-hd-mea-roadmap-implicationcommitment as a corroborating evidence point (the "next-gen HD-MEA field" consolidation narrative now has 3 distinct data points), (c) the Kim paper pairs with Liu 2026 to anchor a newliu-kim-2025-2026-next-gen-hd-mea-roadmapconsolidation synthesis page. - Ajongbolo 2025 Cells brain organoid review (2026-08-23, single-shot LDR entry
ad4abcde, Wiki.js 1743) —obsidian-vault/04-Literature/Deep-Reads/Ajongbolo_2025_Cells_Brain_Organoids_Review.md(11,367 bytes). Ajongbolo AO, Langhans SA, Cells 2025, DOI 10.3390/cells14110842. The paper is the canonical brain organoid + assembloid review for Robin's deep-read set: (i) 3-tier brain-organoid taxonomy — whole-brain organoid (Lancaster 2013 archetype, multi-brain-region identity, unguided spontaneous differentiation) → region-specific organoid (前脑/中脑/小脑/下丘脑 with patterning-factor-guided TF markers FOXG1 / OTX2 / EN1/EN2 / GBX2 / FGF8 / SHH) → complex organoid systems (assembloid multi-region fusion / OoC vascularization-perfusion / tumoroid tumor modeling / xenograft immunodeficient-mouse intracranial transplant); (ii) 4-class characterization methodology — morphological (IF + confocal) + biochemical (qPCR/Western/bulk RNA-seq) + functional (MEA / patch clamp / calcium imaging) + omics (scRNA-seq / spatial transcriptomics / mass spec) = standardized decision tree for any new brain-organoid line publication; (iii) disease-modeling real-world boundaries — neurodevelopmental (microcephaly / macrocephaly / ASD / Rett / Fragile X / Timothy syndrome) + neurodegenerative (AD / PD / HD / ALS) + brain-tumor (glioblastoma / medulloblastoma / AT/RT); (iv) drug-discovery pipeline standardization — 96-well + microfluidic chip + automated imaging + AI phenotype recognition → emerging HTS platform. Net-new external evidence in this run. Vendor-anchor mapping: CelVivo ClinoStar-adjacent (long-term stable brain organoid culture) + 3Brain HD-MEA-adjacent (functional electrophysiology read-out via MEA in the 4-class characterization). Cross-vendor: Ajongbolo review is the first comprehensive brain-organoid review in Robin's deep-read set since the 2026-07-29 Organoids 2026 review (10.1186_s40164-026-00743-x) — pairs with that review to give Robin a review-paper anchor for the brain-organoid lane. Track on next fetch whether (a) Robin produces a deep-read synthesis page at/sources/literature-ajongbolo-2025-cells-brain-organoids-review-deepread.md, (b) the review routes into/themes/05-robin-research.mdas a "review-paper cluster" entry alongside the Organoids 2026 review. deepread_40240593/pipeline workspace (2026-08-24, NEW this fetch) —deepread_40240593/is the first new untracked directory added this fetch, alongside the 5 root-level LDR files. The directory contains 7 subdirectories:deepread_40016200+deepread_40441268+deepread_40498018+deepread_40593704+deepread_41151577+deepread_brain_organoid_fluid+deepread_shear_stress_cs_os. The directory is at the vault root (not in04-Literature/); the numeric-name pattern (deepread_<PMID>) suggests Robin's LDR pipeline is using these directories as per-paper working folders — the names include both PMIDs (40016200, 40441268, 40498018, 40593704, 41151577) and human-readable slugs (brain_organoid_fluid → maps to Aiello paper; shear_stress_cs_os → maps to CelVivo App Note). The directory mtime is 2026-08-24 16:31 +0800 (1-day-old at this fetch). Structural significance: (a) thedeepread_<PMID>naming convention is not the prior04-Literature/Deep-Reads/<vendor>/convention — the new pattern is a per-paper working-folder pattern that holds pipeline intermediate artifacts (PDFs, image-extracts, qa-pass outputs, Ollama vision-audit intermediates, etc.) before final commit to04-Literature/Deep-Reads/. (b) The presence of 5 already-committed root-level LDR files (in04-Literature/Deep-Reads/) plus the 2 nameddeepread_<slug>folders (brain_organoid_fluid + shear_stress_cs_os) — which exactly map to 2 of the 5 committed papers — suggests Robin's pipeline writes the committed LDR note to04-Literature/Deep-Reads/and the intermediate artifacts todeepread_40240593/deepread_<slug>/; the other 5 PMID-named subdirs are pipeline intermediates for 5 other in-progress papers not yet onmain. (c) The vault-rootdeepread_40240593/is not yet committed (carry-forward untracked); the 2026-08-23 7-paper burst means Robin is producing pipeline output faster than the manual commit cycle. Carry-forward status (2026-08-24): untracked, 1-day-old at this fetch, future-commit candidate. Track on next fetch whether (a) the directory is committed, (b) more papers move through the pipeline, (c) thedeepread_<PMID>vs04-Literature/Deep-Reads/<slug>separation is formalized in vault conventions. No synthesis routes until the directory is committed.- 2026-08-24/25 cluster — SECOND consecutive single-day 5-paper LDR burst (vault HEAD
fb017e4f→9d4767c7, 5 new vault commits) — the 2026-08-25T18:13Z fetch observed a SECOND consecutive single-day 5-paper LDR burst at vault HEAD. Combined with the 2026-08-23/24 5-paper burst, 10 LDR files in 48 hours, the largest sustained 2-day research output in Robin's vault activity log; the cluster creates 3 NEW04-Literature/Deep-Reads/subfolders:Vascularized-Organoids/(Tevonian + Shen) +Cardiac-Organoids/(Yang) +Skin-Organoids/(Zhai) — Robin expands the deep-read folder taxonomy from ~19 to ~22 in a single day, returning to the per-vendor / per-application-domain subfolder discipline after the 2026-08-23/24 5-paper vault-root burst (the only LDR cluster that landed at the root of04-Literature/Deep-Reads/rather than in a subfolder). The 5-commit cluster is (chronological):089177a7Tevonian 2026 Nat Commun 血管化肝 MPS deep read (PMID 41634021) →583859a8Yang 2026 Stem Cell Res Ther cardiac organoid review (PMID 41963991) →9aa2af4cUpdate Tevonian 2026 + Yang 2026 (CelVivo/Cellink/Mimetas/3Brain/Femtobiomed product mapping retrofit + 净化 Robin mentions — FIRST post-publish vendor-mapping retrofit commit in Robin's LDR pipeline) →5907cdfcShen 2026 Chin Med J vascularized organoids review (PMID 42268296) →9d4767c7Zhai 2026 Sci Adv 3D skin pemphigus (PMID 41512055). Vendor anchor mapping (via9aa2af4cretrofit): 4-vendor (CelVivo / Cellink / Mimetas / 3Brain / Femtobiomed) product mapping applied retroactively to Tevonian + Yang files. Net-new external evidence in this run. Synthesis routes into/themes/01-organoid-equipment.md(vascularized liver MPS + cardiac organoid review + autoimmune dermatology adjacency — likely the first significant expansion of Robin's coverage outside the canonical 4 application domains),/themes/05-robin-research.md(vault-snapshot refresh + the 2.5x expansion of subfolder taxonomy),/sources/literature.md(last-30-days table),/commitments.md(4 new commitment rows),/themes.md(potentialclass-organoid-3d-bioprintingevidence footprint strengthening — 4 of 5 papers are tissue-organoid deep-reads; if the 2026-08-25 burst recurs, the theme row may need a deeper evidence-footprint refresh). Track on next fetch whether (a) more per-vendor / per-application-domain subfolders land (extending the post-root-burst return to subfolder discipline), (b) the9aa2af4cretrofit pattern is applied to the prior 5 papers from the 2026-08-23/24 cluster (currently only Tevonian + Yang got the retrofit), (c) theVascularized-Organoids/+Cardiac-Organoids/+Skin-Organoids/subfolders accumulate additional entries (≥3 total entries per subfolder is the threshold for "subfolder is in active use"), (d) thedeepread_40240593/pipeline workspace directory finally gets committed. - Tevonian 2026 Nat Commun 血管化肝 MPS (2026-08-25, single-shot LDR entry
089177a7, PMID 41634021) —obsidian-vault/04-Literature/Deep-Reads/Vascularized-Organoids/Tevonian_2026_Nat_Commun_Vascularized_Liver_MPS.md. Tevonian et al. (2026) Nat Commun — first vascularized liver MPS (microphysiological system) paper in Robin's deep-read set. Vendor anchor mapping (via9aa2af4cretrofit): the retrofit commit added the 5-vendor product mapping table (CelVivo + Cellink + Mimetas + 3Brain + Femtobiomed) to the file; the deep-read likely ranks Mimetas OrganoPlate for the multi-channel vascularized MPS architecture (OrganoPlate is the canonical microphysiological system for vascularized liver tissue) + CelVivo ClinoReactor for upstream hepatocyte maturation (Hep-Orgs source) + Cellink BIO X for the decellularized liver scaffold matrix. Companion to the existing Liang 2026 liver organoid entry (ClinoStar ⭐⭐⭐⭐ for P1-P10 long-term maturation + ClinoReactor ⭐⭐⭐⭐ for 3-track HEP/CHO/HSC perfusion). Application domain: vascularized liver — extends the existingLiver/subfolder's (6 papers) fibrotic disease modeling story with a vascularization dimension. Net-new external evidence in this run (git-repo-1 2026-08-25). Synthesis routes into/themes/01-organoid-equipment.md(vascularized liver vendor mapping) +/commitments.md(new commitment entry once Robin produces a synthesis page). Track on next fetch whether (a) Robin produces a deep-read synthesis page at/sources/literature-tevonian-2026-nat-commun-vascularized-liver-mps-deepread.md, (b) the retrofitted 5-vendor mapping tables yield specific ROI for the active CelVivo / Cellink / Mimetas / 3Brain / Femtobiomed Chinese pharma R&D / CDMO account targeting, (c) the Tevonian paper pairs with Shen 2026 to anchor avascularized-organoidreview-paper cluster that the existing Subfolder lacks. - Yang 2026 Stem Cell Res Ther cardiac organoid review (2026-08-25, single-shot LDR entry
583859a8, PMID 41963991) —obsidian-vault/04-Literature/Deep-Reads/Cardiac-Organoids/Yang_2026_Stem_Cell_Res_Ther_Cardiac_Organoid_Review.md. Yang L et al. (2026) Stem Cell Res Ther — first comprehensive cardiac organoid review in Robin's deep-read set. Vendor anchor mapping (via9aa2af4cretrofit): the retrofit commit added the 5-vendor product mapping table to the file. Companion to Tian 2025 Nat Commun (the cardiac epicardium mTOR paper from the 2026-08-23 burst) which established the actual mechanistic depth; Yang 2026 is the canonical review that contextualizes Tian alongside the prior cardiac organoid literature (hPSC cardiac organoid generation methods, maturation protocols, disease modeling applications, regenerative medicine routes). Application domain: cardiac organoid — Robin expands from the prior 2-paperCardiac/subfolder to a dedicatedCardiac-Organoids/subfolder; this is the first time Robin has opened a new subfolder explicitly for an application-domain cluster (prior new subfolders have been for review types or vendor types). Net-new external evidence in this run (git-repo-1 2026-08-25). Synthesis routes into/themes/01-organoid-equipment.md(cardiac organoid vendor mapping) +/commitments.md(new commitment entry) +/sources/literature.md(last-30-days table). Track on next fetch whether (a) Robin produces a synthesis page at/sources/literature-yang-2026-stem-cell-res-ther-cardiac-organoid-review-deepread.md, (b) the cardiac-organoid commitment folds Tian + Yang as a paired mechanistic + review cluster, (c) the Cardiac-Organoids subfolder accumulates ≥3 entries. - Shen 2026 Chin Med J vascularized organoids review (2026-08-25, single-shot LDR entry
5907cdfc, PMID 42268296) —obsidian-vault/04-Literature/Deep-Reads/Vascularized-Organoids/Shen_2026_Chin_Med_J_Vascularized_Organoids_Review.md. Shen Y et al. Chin Med J 2026 — Chinese-language peer-reviewed vascularized organoid systematic review; companion to Tevonian 2026 in the same cluster. Vendor anchor mapping: TBD; the deep-read is in the Chinese-language journal 中华医学杂志 (English edition) which makes it a credential Chinese-hospital-academic source for Robin's active Chinese pharma R&D / CDMO customer base. Application domain: vascularized organoid — adds a 2-paper cluster to the newVascularized-Organoids/subfolder. The Shen 2026 review is the review-paper anchor for the new subfolder (review-type) and the Tevonian 2026 primary research paper is the research-paper anchor (primary-type). Net-new external evidence in this run. Track on next fetch whether Robin produces a deep-read synthesis page and whether the Chinese-language source yields any CelVivo-specific IRB or vascularization positioning material. - Zhai 2026 Sci Adv 3D skin pemphigus (2026-08-25, single-shot LDR entry
9d4767c7, PMID 41512055) —obsidian-vault/04-Literature/Deep-Reads/Skin-Organoids/Zhai_2026_Sci_Adv_3D_Skin_Pemphigus.md. Zhai T et al. Sci Adv 2026 — first 3D-skin organoid disease-modeling paper in Robin's deep-read set; net-new application domain (autoimmune dermatology + 3D skin) that Robin's existing ~22 deep-read subfolders do not cover. Vendor anchor mapping: TBD; the deep-read does not have the9aa2af4cretrofit 5-vendor mapping (the retrofit was applied only to Tevonian + Yang); skin organoid is a candidate workflow for CelVivo ClinoReactor (long-term 3D skin culture — similar to the existing liver, brain, lung, retinal organoid applications) but the Sci Adv paper's specific ClinoReactor / ClinoStar callouts are not in the manifest entry. Application domain: 3D skin organoid + autoimmune dermatology (pemphigus) — distinct from the existing Cancer / Brain / Liver / Vascularized-Organoids / Cardiac-Organoids / Kidney / Retinal / Brain-Tumor application-domain subfolders. Net-new external evidence in this run. Synthesis routes into/themes/01-organoid-equipment.md(autoimmune dermatology adjacency to the vascularized-organoid cluster) +/commitments.md(new commitment entry). Track on next fetch whether (a) Robin produces a deep-read synthesis page, (b) the Skin-Organoids subfolder accumulates ≥3 entries to confirm a recurring application-domain pattern, (c) the Zhai paper yields Chinese cosmetic / dermatology pharma R&D positioning material that the active CRM portfolio could absorb. 9aa2af4cpost-publish vendor-mapping retrofit commit (2026-08-25, NEW SOP step in Robin's LDR pipeline) —9aa2af4cis a non-paper-content commit that touches the Tevonian 2026 + Yang 2026 files in-place to add the 5-vendor product mapping table (CelVivo / Cellink / Mimetas / 3Brain / Femtobiomed) plus 净化 Robin mentions (sanitization of any "Robin" / "Robin 8-XX 实战沉淀" attribution strings that might leak into the production deep-read narrative). The commit is the first post-publish vendor-mapping retrofit in Robin's LDR pipeline; the prior 5-paper 2026-08-23/24 cluster (Ajongbolo + Kim + Tian + Aiello + CelVivo App Note) did NOT receive the retrofit — only the new Tevonian + Yang pair got the retroactive 5-vendor mapping. The retrofit is methodologically significant: it indicates Robin's LDR workflow is now adding a post-publish vendor-mapping step to the standard 8-step SOP (the 8 铁律 + 3 trigger modes + 5-section report pattern at/sources/ldr-report-template.md). The prior 8-step SOP does not include a vendor-mapping retrofit step — Robin has effectively iterated to a 9-step SOP for the new Tevonian + Yang pair. The retrofit's 净化 Robin mentions specifically addresses the "客户-facing deep-read 净化" concern flagged in the prior synthesis policy — Robin's deep-reads are increasingly being routed into customer conversations (the Guo 2026 IRB checklist template is the canonical example) and any Robin attribution in the body could break the "vendor-anchored customer-facing artifact" framing. Track on next fetch whether (a) the9aa2af4cretrofit pattern is applied retroactively to the prior 5 papers (Ajongbolo + Kim + Tian + Aiello + CelVivo App Note) — if Robin retro-fits the vendor mapping, the existingclass-organoid-3d-bioprintingtheme evidence footprint strengthens materially; if not, the retrofit might be an LDR-pipeline ad-hoc patch rather than a recurring pattern; (b) the9aa2af4cretrofit becomes a standard LDR step (replacing the existing 8-step SOP iteration pattern); (c) the LDR SOP iteration is documented at/sources/ldr-report-template.mdand/sources/2026-07-27-4-27-sop-vs-implementation.md.- Quintard 2024 Nat Commun microfluidic vascularized organoid chip (2026-08-16, 7 commits in 48-hour window) —
obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md(189 lines; 4-commit LDR cycle0fc8db24adds →290e9635-v2 修图床/双 H1/落款 →24c713de-v3 Wiki.js 自带图床 6 张图 →4073abf4-v4 转发语标题/落款加粗/删 3Brain; Wiki IDs 1719/1720/1722, NocoDB Id 3297). The paper is the first microfluidic / organ-on-chip platform paper Robin has deep-read in the 2026-08 window; the platform combines (i) 10-channel parallel microfluidic chips with U-shaped capture sites (300-800 µm adjustable), (ii) fibrin + Matrigel hydrogel layer deposition using Landau-Levich-Bretherton effect, (iii) ~10 s capture efficiency ~100%, (iv) dynamic perfusion 7-30 days with HUVEC + fibroblast co-culture + hiPSC-derived BVO + islet spheroid + lung organoid cross-validation, (v) hierarchical vasculature (37 µm upstream artery-vein + 8 µm BVO capillaries, matching physiological ranges 50-1900 s⁻¹). Net-new external evidence in this run (git-repo-1 2026-08-17). The 4-star "与我们的产品" table lists Mimetas OrganoPlate ⭐⭐⭐⭐ (direct Phaseguide-based vascularized / kidney / intestine organ-on-chip competitor) + CelVivo ClinoStar ⭐⭐⭐ (upstream workflow step: BVO differentiation day 0-15 needs rotating-wall suspension culture; ClinoStar is the canonical hardware for this stage; the paper's day 15 → chip-on-board handoff is the canonical CelVivo → organ-on-chip workflow) + Emulate Organ-Chip ⭐⭐⭐ (Colon-Intestine-Liver platform companion). Synthesis routes into/themes/05-robin-research.md(新增 by-vendor entry) and/sources/literature.md(last-30-days deep-read table). Vendor-anchor mapping: CelVivo-adjacent (workflow upstream) + Mimetas OrganoPlate / Emulate Organ-Chip (organ-on-chip product lane that Robin's portfolio does not currently cover but represents a potential cross-sell if Robin's customers ask "where do I run my CelVivo-matured organoids in a vascularized microenvironment?"). Customer-entry: 药企临床前 (vascularized drug screening) + 微流控 organ-on-chip 平台集成商 (Mimetas / Emulate channel partners) + academic PI (vascular development / diabetes). Track on next fetch whether Robin publishes a/sources/literature-quintard-2024-nat-commun-vasorganoid-chip-deepread.mdsynthesis page; the deep-read pipeline currently only carriesliang-2026-celvivo-clinostar-positioning+miao-2025-celvivo-clinostar-positioning+liu-2026-hd-mea-roadmap-implication+sharma-2026-retinal-organoid-mea-cross-sell— no Quintard synthesis page yet. - Guo 2026 Front Cell Dev Biol organoid ethics systematic review (2026-08-16, 7 commits in 48-hour window) —
obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md(170 lines + 3 真图; 3-commit LDR cycle2e6f5989adds →00f824f2-v2 修图床 (加 2 张 Wiki.js 自带图) →a4fa5a32-v3 补 Fig 1; Wiki ID 1724, NocoDB Id 3298). The paper is the first organoid-research ethics / IRB systematic review Robin has deep-read in any window — fills the methodological gap on the IRB-side that the prior clinical-translation evidence (CDE classification + Order No. 818) does not directly cover. The paper structures the IRB review framework as 7 mandatory points (sample provenance + donor informed consent + data privacy & de-identification + co-culture agency + animal welfare 3R + cross-border regulation + long-term storage & termination); the cross-border table compares China (《人类遗传资源管理条例》+ 《涉及人的生命科学和医学研究伦理审查办法》2023), US (HIPAA + Common Rule + NIH GDS), EU (GDPR + Clinical Trials Regulation 536/2014), Japan, Korea. The 4-star "与我们的产品" table lists CelVivo ClinoStar ⭐⭐⭐⭐ (clinical-translation IRB compliance — the 7 mandatory points directly apply to ClinoStar customer IRB submissions; Robin 推广 ClinoStar 给三甲医院时, 可附带本框架作为增值) + Mimetas OrganoPlate ⭐⭐⭐⭐ (co-culture ethics — Mimetas 主营类器官 + 免疫细胞共培养, the co-culture agency framework from Guo 2026 point 4 directly applies) + Emulate Organ-Chip ⭐⭐⭐ (organoid + microfluidic cross-border regulation reference). Net-new external evidence in this run (git-repo-1 2026-08-17). Robin translated the paper into a customer-facing sales ammunition template attemplates/类器官IRB申请清单.md(180 lines; 7 mandatory points checklist + 5 customer Q&A + China vs International flow table + 10 attachments + 7 citations; v1.0 dated 2026-08-16, "Robin 8-16 实战沉淀") — see the templates/ entry in the next bullet. Customer-entry: 临床转化型医院 (class A tertiary hospitals running organoid IRB submissions) + 类器官厂家 Robin 培训客户 (the IRB checklist is the canonical "Robin 培训客户 IRB 申请" core material) + academic PI (cross-border collaboration IRB paperwork). Track on next fetch whether (a) the templates/ IRB checklist gets committed, (b) the Robin-author attribution in the template is recognized as a wiki-side customer-training artifact, (c) Robin produces a deep-read synthesis page at/sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md, and (d) the IRB checklist routes into the existing CelVivo industrial-customers program (which currently lives at05-Documents/Products/Celvivo/Industrial-Customers/) as a standard customer-training artifact. - Review/ subfolder — first entry (2026-08-13, still uncommitted at 2026-08-23, 12-day carry-forward, watchlist signal continuing to weaken) —
obsidian-vault/04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.mdis the first file in a newReview/subfolder under04-Literature/Deep-Reads/. The file is untracked at the 2026-08-23 fetch (Robin has not yet committed it — same state as the 2026-08-13 + 2026-08-15 + 2026-08-17 + 2026-08-18 + 2026-08-19 + 2026-08-20 + 2026-08-21 + 2026-08-22 fetches, 0 progress in the 2026-08-13 → 2026-08-23 240-hour window, 10 consecutive fetches silent on the file). Watchlist signal continuing to weaken at this fetch: per the 2026-08-15 watchlist-trigger rubric ("if the file remains uncommitted at the next fetch (2026-08-17 or later), the structural signal weakens"), theReview/subfolder at the 2026-08-23 fetch is still single-entry, still untracked — the structural signal continues to weaken at this fetch (12-day carry-forward with no commit, no follow-up paper landed in the subfolder across 10 consecutive fetches). TheReview/subfolder is more likely to be a one-off than a recurring pattern. The file should either be committed on a future fetch (which would re-strengthen the signal) or remain untracked indefinitely (which would confirm the one-off interpretation). No synthesis routes until the file is committed. templates/subfolder — first entry (2026-08-16, NEW this run) —templates/类器官IRB申请清单.md(180 lines, mtime 2026-08-16, untracked) is the first file in a newtemplates/directory at the vault root. The file is Robin's first customer-facing sales ammunition template produced from a single deep-read (the Guo 2026 IRB ethics systematic review). Content: 7 mandatory IRB review points checklist (样本来源/知情同意/数据隐私/共培养主体性/3R 动物福利/跨境监管/长期保存与终止使用) + 5 customer Q&A ("类器官研究要不要 IRB 申请?" / "类器官共培养产品怎么申请 IRB?" / "类器官跨境研究怎么报?" / "3R 原则怎么写?" / "类器官 + 免疫细胞共培养 = CAR-T 体外培养, 算不算新生物体? 伦理上算什么?") + China vs International flow comparison table + 10-row 申请附件清单 + 7 references (Guo 2026 + ISSCR 2021 + OHRP 2016 + GDPR 2018 + China 2023 + China 2019 + Cambridge 2020). The template'sversion: v1.0 (2026-08-16, Robin 8-16 实战沉淀)andRobin 业务定位: 类器官厂家给三甲医院 IRB 申请的标准模板 + Robin 客户培训材料核心framing makes it explicit that this is the canonical "Robin 培训客户 IRB 申请" core material. Structural significance: thetemplates/directory is new — none of the existing top-level folders (01-Active-Sales//02-Clients//02-Active-Deals//02-Contacts//03-Product//03-Resources//04-Literature//05-Documents//06-Sales//99-Templates//memory/) provides a vendor-agnostic customer-training-artifact slot at the vault root. The Obsidian vault already has99-Templates/for reusable Obsidian templates (note templates, daily-report templates — per99-Templates/size hint 14 .md), but the newtemplates/directory is for customer-facing sales ammunition, not Obsidian note templates — a different artifact type. The naming convention overlaps with99-Templates/and may need disambiguation; Robin's intent (per the file header) is for thistemplates/to be the canonical customer-training artifact directory, distinct from99-Templates/Obsidian-note templates. Customer-entry scenarios called out in the template: (a) 类器官厂家研发负责人 = IRB 申请准备, (b) Robin 客户开发 = 培训客户 IRB 申请核心材料, (c) 医院 IRB 委员会 = 类器官研究 IRB 审查标准参考, (d) 学术合作方 = 跨境合作时多国法规差异对照. Carry-forward status (2026-08-23): untracked, 7-day carry-forward since first observation (2026-08-17 fetch — was 6-day at the 2026-08-22 fetch, 5-day at the 2026-08-21 fetch), future-commit candidate. Track on next fetch whether (a) Robin commits the file tomain, (b) more templates land in the directory (extending the customer-training-artifact slot), (c) thetemplates/and99-Templates/naming overlap gets resolved (rename / docs / conventions). Synthesis routes into/themes/05-robin-research.md(sales ammunition pipeline section).celvivo_commercial/subfolder — first entry (2026-08-17, NEW this run) —celvivo_commercial/1331651_20260630_131201.pdf(56 KB PDF, mtime 2026-08-17, untracked) is the first file in a newcelvivo_commercial/directory at the vault root. The PDF is the existing 6-30 quote PDF that Robin migrated into a new folder. The file is a quote PDF, not a synthesis target — the on-disk evidence is the existing 6-30 quote document that already exists in05-Documents/Products/Celvivo/Industrial-Customers/(per the 2026-08-15 synthesis-policy section above, "commercial docs (8 files: Exhibit 1 Price Book / Exhibit 3 SuperUser certification / Huibai demo discount agreement / 惠百 PO 盖章版 / Celvivo Distribution Agreement 2026 Huibai Bio / 1331651_20260630_131201 (6-30 quote) / Packing Slip Ordre 726_1 / Packing Slip Ordre 726_2)"). Structural significance: thecelvivo_commercial/directory is new — Robin has migrated the 6-30 quote out of wherever it was previously (presumably a working folder or05-Documents/Products/Celvivo/deep path) into a top-level dedicated directory. The migration is unfinished — only 1 file in the new directory; if Robin intends the directory to consolidate all 8 commercial docs from05-Documents/Products/Celvivo/Industrial-Customers/, the other 7 files (Exhibit 1 Price Book / Exhibit 3 SuperUser certification / Huibai demo discount agreement / 惠百 PO 盖章版 / Celvivo Distribution Agreement 2026 / Packing Slip Ordre 726_1 / Packing Slip Ordre 726_2) should eventually land here too. No synthesis routes until Robin commits the file or migrates more docs into the directory. Carry-forward status (2026-08-23): untracked, single-entry, 7-day carry-forward since first observation (2026-08-17 fetch — was 6-day at the 2026-08-22 fetch, 5-day at the 2026-08-21 fetch), future-commit candidate. Track on next fetch whether (a) the file gets committed, (b) more commercial docs migrate into the directory.- 2026-08-15 sources-sync bug — count-data wipe (operational) — the
2507925e27b83b4f9d2e6f3b9c939d081a90f9f2chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-15)commit at 2026-08-15 +0800 02:31 committed empty count values for NocoDB / Wiki.js / RAGFlow (SeaFile was already empty so the commit was a no-op there): (a) NocoDB: 6614 → 0 total records, with all 13 per-table counts (brain_organoid_literature / intestinal_organoid_literature / Celvivo_literature / cardiac_organoid_literature / cancer_organoid_literature / liver_organoid_literature / other_organoid_literature / kidney_organoid_literature / retinal_organoid_literature / Cellink_literature / organoid_literature_old / lung_organoid_literature / 3Brain_literature) cleared to empty cells; (b) SeaFile: libraries table unchanged (was empty in1737454already — a separate, older cron issue not introduced by2507925); (c) Wiki.js: 83 → 0 unique pages, ID range 22..1704 → 0..0, Locale 分布 → empty, Top-level 路径分布 → empty; (d) RAGFlow: landing 200 → 000,/api/v1/health404 → 000,/api/v1/datasets401 → 000. The header lines on each affected/sources/{nocodb,ragflow,seafile,wikijs}.mdpage still report上次同步: 2026-08-14T18:30:42Z(the prior successful sync timestamp), but the body count values are wiped. Probable root cause: the auto-source-sync CRON job ran but the underlying NocoDB / Wiki.js / RAGFlow API calls failed (likely the same operational issue already documented on/sources/web-search.mdand/sources/README.md— runtime registry disagreement onenabled: truevs. disabled); the script committed the empty values instead of skipping the commit on failure. Impact: 3 source pages now show misleading zero/null values (NocoDB / Wiki.js / RAGFlow); Tavily / HN / git-repo synthesis is unaffected. Recovery: the wiped data is recoverable from the prior wiki commit (git show 1737454:sources/nocodb.mdetc. will restore the pre-wipe state). This run restored the wiped data on all 3 affected pages (plus an operational note documenting the bug) so the wiki is internally consistent again. Wiki-synthesis concern: none — the synthesis layer (themes / commitments / open-questions / personal-logistics) is independent of the source-page counters. Operational concern: yes — the auto-source-sync job should (a) check connectivity before committing, (b) skip the commit on API failure rather than committing empty values, or (c) preserve the prior counter values when a fresh pull returns null/empty. Recorded for traceability here + on each affected/sources/{nocodb,ragflow,seafile,wikijs}.mdpage. - Liang 2026 liver organoid fibrosis platform (2026-08-12) —
04-Literature/Deep-Reads/Liver/2026-08-12_Liang_2026_SciRep_liver_organoid_fibrosis_platform.md(170 lines;[[MOC-类器官与3D培养]]already names this paper viarelated:back-link). The paper is the net-new external evidence this run (git-repo-1 2026-08-12) brought into the vault; see synthesis at/themes/01-organoid-equipment.md§ CelVivo evidence (added 2026-08-12) and/commitments.mdliang-2026-celvivo-clinostar-positioning. Single-paper LDR cycle: 4 commits (e542c977→8699a154→aacba7aa→297f106d) walked Robin's standard 3-stage SOP on the same file (186 lines → 105+/122- page 946 rewrite → page 934 修齐 micro-revisions). The 4-star "与我们的产品" table on the paper lists CelVivo ClinoStar ⭐⭐⭐⭐ (P1-P10 长程扩增对应旋转培养 30+ 天无剪切; HSC 静止态在模拟微重力下 7+ 天维持) + CelVivo ClinoReactor ⭐⭐⭐⭐ (单组织 3 轨道分通道灌流; TGFβ 时间程序精确切换) — parallel CelVivo ClinoStar rating 5 to Miao 2025 v2's ClinoStar rating 5 from the 2026-08-08 flywheel-sync, but for liver organoid (long-term maturation + fibrosis modeling) rather than lung organoid (vascularization). 7 SeaFile Fig (Fig1-7) + 4-paper 参考文献 (Huch 2013 / Huch 2015 / Clevers 2016). Customer-entry: 药企临床前 (抗纤维化药筛) + 临床肝活检中心 (1-2 mg → 3 周药敏) + 学术 PI (2D vs 3D 旋转 efficiency). MOC linkage: the paper'srelated:field already names[[MOC-类器官与3D培养]](the first MOC, created 2026-08-10) — confirming the MOC pattern is in active use on real deep-reads. - CelVivo industrial customers program — a dedicated subfolder under
05-Documents/Products/Celvivo/Industrial-Customers/holdsCelVivo_中国工业 客户开发研究报告(v1 + v2),客户管线定位_1页图, and工业客户开发手册-v3. This is a self-contained CelVivo China commercial effort. - CelVivo sales training cluster —
06-Sales/Content/Training-Materials/contains aRobin稿生成通字稿family (v3–v6), aCelVivo赋能培训PowerPoint family (v1–v9, depth-flavored edits), and a销售基础话术包pair. Versions progress from 基础 → 5大管线 → 深度版 → 终稿修正 → 销量仅看. - 3Brain end-customer dossier set — 11+ dossiers under
03-Resources/End-Customers/covering 神经所 (上海), 北京大学, 北京天坛医院, 浙大一附院, 中科院昆明动物所, 西南医科大学, 贵州医科大学, plus TCM accounts at 云南中医药大学 and 天津创新中药. - CelVivo distributor technical contact (2026-07-28, partially resolved
2026-08-07) —
02-Clients/Agents/董慧群.mdis the first profile under the02-Clients/Agents/bucket (frontmattertype: agent, role: 代理商技术同事, products: CelVivo ClinoStar / ClinoReactor). The 2026-08-07_known_associations.mdindex now identifies the CelVivo dealer as 济南成全生物科技 (曹沛起) — the only ClinoStar agent in the 259-dealer list, registered in both 华北 + 山东. Robin still needs to confirm: (a) is 董慧群 the same agency? (b) phone / WeChat / served end-customers / opportunities. The agency-side gap is now closed. - ITX 24h host build (first observed 2026-07-31; still untracked) —
03-Resources/ITX-24h-Host/ITX_24h_Host_v18_Config_2026-07-31.mdis a top-level bucket first observed between the 2026-07-30T18:13 fetch and the 2026-07-31T18:08 fetch; it remains untracked. Single file: Robin's personal 24h server build plan for hosting Hermes Agent + AI workflow stack — mATX + i5-12400 + DDR4-2666 32G + 板载 Realtek 1Gb + Intel PRO/1000 GT 双网卡 NAS 隔离, ¥2,985.82, 10/11 parts arrived, planned hostnames/roles: 192.168.31.100 (主力机 SSH) vs 10.10.10.254 (RAGFlow / NAS RAGFlow API). Workflow-tooling priority LOW (not vendor-anchored), so it does not earn a/themes.mdrow, but the build remains a source-anchored personal-infra work item and was promoted to/commitments.mdasitx-24h-host-build-2026-q3(Owner: me) for the post-assembly steps (Ubuntu Server 22.04 install + 双网卡静态 IP + Hermes Agent install + 24h soak test). - Cells + 2026-08-08 cluster — Fernandez Vallone 2026 Cells (hiPSC
brain organoids for THSDC chemical screening, NAMs platform) is the
first
04-Literature/Deep-Reads/Cells/entry. New application domain (toxicology + NAMs) compared to the prior Brain / Cancer / Liver buckets. CelVivo + 3Brain application scenarios called out in tags. - Microbioreactor + 2026-08-07 cluster — Rosero 2026 Front Bioeng
Biotechnol Microbioreactor design Mini Review is the first
04-Literature/Deep-Reads/Microbioreactor/entry. Cross-vendor adjacent (CelVivo ClinoStar / Cellink BIO X / FemtoBiomed CellShot). Landed in NocoDBRobin_Picked_Papers(PMID 42516424, Wiki.js ID 1696). - Parfitt 2024 Nat Commun (DJ1 LOF midbrain organoid + PD) —
untracked file
04-Literature/Deep-Reads/Brain/2026-08-06_Parfitt_GM_et_al_NatCommun_2024_DJ1_LOF_midbrain_organoid_PD.md(15,972 bytes, mtime 2026-08-06). DJ1 LOF through astrocyte lysosomal dysfunction → AGE → α-syn → DA neuron death; CelVivo + 3Brain application scenarios in tags. Not yet onmain; pending Robin commit. - CellSweep — referenced in the wiki goal focus areas; not surfaced as a
top-level vault folder in this run, so it likely lives under
Work/orscripts/(outside the navigation index). - Phase A metadata batch + first MOC (2026-08-10) — Robin ran a
frontmatter-hygiene + MOC-discipline sprint on 2026-08-10:
(a)
d97b39edPhase A 批量 standardized 6 deep-read notes with the 6-field frontmatter (doi / journal / year / volume / pages / authors array / pmid) —Organoids 2026 review+CelVivo PAH Metabolomics+Shin 2024 thalamocortical organoids 22q11ds+Fernandez Vallone 2026 Cells THSDC+Liu 2026 NBME shape-conformal organoid+类器官综述_CMOS_HD_MEA_类器官电生理_2026-06-05; (b)6b717aefMOC 方案 1 样品 created the first MOC at04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md(95 lines, 沙牛《AI 时代的 Obsidian 公开课》课时 1 pattern,type: moc) and addedrelated:back-link frontmatter to 7 papers; (c)3b929c2fwang2024 方案 2 样品 added 7 image alt descriptions on top of the 6-field frontmatter forwang2024-org-on-chip.md. The MOC's ownrelated:list already names[[MOC-3Brain-HD-MEA]]as the next planned MOC, plus[[02-Clients/Agents/_known_associations]]and[[02-Active-Deals/CellShot-TriArm-Demo-计划-v2-老师版-2026-07-20]], so the pattern is expected to extend. None of the changes add new external evidence — the 6 papers already existed onmain; this commit set only normalizes their metadata and cross-references. The MOC creation is the first durable structural artifact on the knowledge-graph side and is worth tracking on the next git-repo fetch.
Synthesis policy for this source
-
This run (2026-08-25, git-repo-1 18:13Z): 5 new vault commits in the 2026-08-24T18:05Z → 2026-08-25T18:13Z 24-hour window — the vault HEAD bumped from
fb017e4f(2026-08-24T18:05Z fetch) to9d4767c7(2026-08-25T18:13Z fetch) — SECOND consecutive single-day 5-paper LDR burst at vault HEAD. Combined with the 2026-08-23/24 5-paper burst, 10 LDR files in 48 hours, the largest sustained 2-day research output in Robin's vault activity log. The 2026-08-25 cluster returns to the per-vendor / per-application-domain subfolder discipline (Tevonian →Vascularized-Organoids/+ Shen →Vascularized-Organoids/+ Yang →Cardiac-Organoids/+ Zhai →Skin-Organoids/), creating 3 NEW subfolders in04-Literature/Deep-Reads/(one less than the 5 papers, because Tevonian + Shen share theVascularized-Organoids/subfolder). The 5 commits are (a)089177a7Tevonian 2026 Nat Commun 血管化肝 MPS deep read (PMID 41634021) — first vascularized liver MPS paper + first file in the newVascularized-Organoids/subfolder; (b)583859a8Yang 2026 Stem Cell Res Ther cardiac organoid review (PMID 41963991) — first comprehensive cardiac organoid review + first file in the newCardiac-Organoids/subfolder; (c)9aa2af4cpost-publish vendor-mapping retrofit commit on Tevonian + Yang files — FIRST post-publish vendor-mapping retrofit in Robin's LDR pipeline (adds CelVivo / Cellink / Mimetas / 3Brain / Femtobiomed 5-vendor mapping + 净化 Robin mentions); (d)5907cdfcShen 2026 Chin Med J vascularized organoids review (PMID 42268296) — Chinese-language peer-reviewed vascularized organoid systematic review + second file in the newVascularized-Organoids/subfolder; (e)9d4767c7Zhai 2026 Sci Adv 3D skin pemphigus (PMID 41512055) — first 3D skin organoid disease-modeling paper + first file in the newSkin-Organoids/subfolder (NEW application domain — autoimmune dermatology + 3D skin). The 2026-08-24/25 cluster differs from the prior 2026-08-23/24 cluster in three ways: (i) all 5 files landed in per-application-domain subfolders rather than at the04-Literature/Deep-Reads/root (return to standard subfolder discipline after the 2026-08-23/24 root-level non-standard pattern); (ii) the cluster includes a non-paper-content retrofit commit (9aa2af4c) which reflects a new SOP step not present in the prior 8 铁律 + 3 trigger modes pattern; (iii) the cluster's application-domain coverage expands into autoimmune dermatology (Zhai skin) which is the first new application-domain subfolder Robin has opened since the 2026-08-13 Review subfolder was added (and even then, Review is type-based, not application-domain-based). Vendor anchor mapping via the9aa2af4cretrofit: 5-vendor product mapping applied retroactively to Tevonian + Yang; the prior 5-paper 2026-08-23/24 cluster (Ajongbolo + Kim + Tian + Aiello + CelVivo App Note) did NOT receive retroactive retrofit — Tevonian- Yang are the first LDR files to use the new post-publish vendor-mapping
step. Net-new external evidence in this run (4 paper deep-reads + 1
retrofit commit) — CelVivo/Cellink/Mimetas/3Brain/Femtobiomed product
mapping table is the net-new contribution. Wiki-side: 2 new
automated wiki commits landed in the 2026-08-24T18:05Z →
2026-08-25T18:13Z 24-hour window —
3255613chore: daily update 2026-08-25 (2026-08-25 02:23 +0800; pergit show --stat 3255613the commit touched 17 files includingcommitments.md+sources/git-repo.md+sources/hackernews.md+sources/index.md+sources/literature.md+sources/nocodb.md+sources/openwiki-version-drift.md+sources/ragflow.md+sources/seafile.md+sources/web-search.md+sources/wikijs.md+index.md+quickstart.md+sources/README.md themes.md+themes/05-robin-research.md+themes/index.md) +1003b92chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-25, 2026-08-25 02:30 +0800 — the eleventh consecutive sources-sync re-applying the25079252026-08-15 count-data wipe pattern after997b6482026-08-16 +be492852026-08-17 +1fc73ae2026-08-18 +dcb53a22026-08-19 +bd303392026-08-20 +f6c25762026-08-21 +43d45482026-08-22 +8f8f7672026-08-23 +127c2dc2026-08-24 + now1003b922026-08-25). Both commits are routine auto-orchestration: (a) the3255613daily update carried the synthesis-layer edits from the prior HN-1 2026-08-25T18:00Z + web-search-1 2026-08-25 (skipped) + git-repo-1 2026-08-24T18:05Z runs; the3255613daily update committed 17 of the prior dirty files; (b) the1003b92sources-sync re-applied the count-data wipe pattern on NocoDB / SeaFile / Wiki.js / RAGFlow for the eleventh consecutive sources-sync. The manifestchangedFilesshows 11 dirty wiki files this fetch —M .last-update.json+M index.md+M quickstart.md+M sources/README.md+M sources/git-repo.md+M sources/hackernews.mdM sources/literature.md+M sources/nocodb.md+M sources/ragflow.mdM sources/seafile.md+M sources/web-search.md+M sources/wikijs.md. Net-new external evidence in this run: 4 new paper deep-reads (1 vascularized liver MPS primary research + 1 cardiac organoid review + 1 vascularized organoid Chinese-language review + 1 3D skin pemphigus primary research) + 1 vendor-mapping retrofit commit. New commitments added on/commitments.md: (a)tevonian-2026-vascularized-liver-mps-positioning(Mimetas OrganoPlate + CelVivo ClinoReactor + Cellink BIO X vendor mapping for vascularized liver MPS); (b)yang-2026-cardiac-organoid-review-positioning(canonical cardiac organoid review that contextualizes the Tian 2025 epicardium mTOR deep-read); (c)shen-2026-vascularized-organoid-chinese-review(Chinese-language peer-reviewed systematic review for Chinese-hospital IRB positioning); (d)zhai-2026-skin-organoid-pemphigus-positioning(first autoimmune dermatology + 3D skin entry, candidate workflow for CelVivo ClinoReactor long-term 3D skin culture). New themes-row refresh candidate for/themes.mdclass-organoid-3d-bioprinting: the 2026-08-24/25 5-paper cluster is the SECOND consecutive single-day 5-paper burst in 48 hours, the 2-day burst is the largest sustained 2-day research output in Robin's vault activity log, and the new application-domain subfolders (Vascularized-Organoids + Cardiac-Organoids + Skin-Organoids) materially expand the per-application-domain subfolder taxonomy. Theclass-organoid-3d-bioprintingrow's evidence footprint is materially strengthened even with no formal row-level Last-seen refresh. Wiki edits this run: (a)/sources/git-repo.md(this page) — refreshed frontmatter HEAD pointers (vault HEADfb017e4f→9d4767c7, wiki HEAD127c2dc→1003b92, tags +2026-08-25, timestamp →2026-08-25T18:13:00Z), refreshed the Connector / State section to the new2026-08-25T18-13-42-494Zraw manifest, refreshed the obsidian-vault working-tree-status section to 2026-08-25 (5 new vault commits,Review/13-day → 14-day carry-forward +templates/+celvivo_commercial/8-day → 9-day carry-forward +deepread_40240593/1-day → 2-day carry-forward), refreshed the openwiki-wiki working-tree-status section to 2026-08-25 (2 new automated wiki commits + 11 uncommitted synthesis- layer edits per the manifestchangedFileslist — +3 vs the 8-dirty-file baseline at the 2026-08-24 fetch because the3255613daily update added 3 newly dirty files:index.md+quickstart.md+sources/git-repo.mdvs the 2026-08-24 prior baseline), added 5 new entries at the top of the Recent-commits-for-vault table (9d4767c7Zhai +5907cdfcShen +9aa2af4cvendor-mapping retrofit +583859a8Yang +089177a7Tevonian), added 2 new entries at the top of the Recent-commits-for-wiki table (1003b92sources-sync 2026-08-25 +3255613daily update 2026-08-25), refreshed the Summary-of-last-48-hours table to add the 2026-08-24T18:05Z → 2026-08-25T18:13Z window data (5 vault commits / 2 wiki commits / operational row noting the eleventh consecutive sources-sync re-applying the count-data wipe pattern + the SECOND 5-paper LDR burst detail), refreshed the04-Literature/Deep-Reads/breakdown table (added 3 new subfoldersVascularized-Organoids/+Cardiac-Organoids/Skin-Organoids/+ bumped total 1,212 → 1,217 +Review/13-day → 14-day +celvivo_commercial/+templates/8-day → 9-day carry-forward), added 7 new entries to the Notable-entity section (the 2026-08-24/25 cluster overview + 4 individual paper entries +9aa2af4cretrofit pattern entry +Review/13 → 14-day carry-forward bump); refreshed the Synthesis-policy section with this run's delta summary (the old 2026-08-24 "This run" was demoted to "Previous run" and the new "This run" reflects the 2026-08-24/25 SECOND consecutive 5-paper LDR burst); (b)/themes/05-robin-research.md— vault-snapshot metadata refreshed (fetch timestamp →2026-08-25T18:13:00Z, raw-manifest path → the new2026-08-25T18-13-42-494Zmanifest, HEAD bumpedfb017e4f→9d4767c7, the SECOND 5-paper LDR burst noted in the cluster section + 3 new subfolders + the9aa2af4cretrofit pattern); (c)/commitments.md— added 4 new commitment entries corresponding to the 4 new LDR papers (each with Owner: me + Source: git-repo-1 2026-08-25 + Status: open); (d)/sources/literature.md— added 4 new rows to the "Last 30 days of deep reads" table under a new2026-08-25subsection; (e)/quickstart.md— added this "Latest update — git-repo-1 (2026-08-25T18:13Z)" paragraph; updated the Backlog git-repo entry to reflect the new wiki HEAD1003b92+ 2 new automated wiki commits + the carry-forward 11 uncommitted synthesis-layer edits + the eleventh consecutive sources-sync note + the SECOND 5-paper LDR burst detail; (f)/sources/README.md— refreshed Active connectors Git repo row + Connector roll Git repo row to mention the 2026-08-25 18:13 UTC fetch + the eleventh consecutive sources-sync + the 5 new vault commits + the 3 new subfolders. No new/themes.mdrow added — the existingclass-organoid-3d-bioprintingrow's evidence footprint is materially strengthened (10 papers in 48 hours, 3 new application-domain subfolders) but the theme row already covers the same general topic; per scope discipline, theme-row additions require a topic-key that doesn't already exist; (the recurrent nature of the LDR burst — 2 consecutive 5-paper clusters in 48 hours — is the strongest evidence to date that Robin has entered a "research-sprint mode" that might justify a futurerobin-research-sprint-2026-08-23-25watchlist row, but such a row would be too transient for the durable/themes.mdindex). No/open-questions.mdrow added — none of the 4 new LDR papers surfaces a new memory/wiki gap; the existing 5 active open questions (agent-dong-huiqun-celvivo / liu-2026-rogers-lab-vs-3brain-relationship / chengdu-baile-vs-lidesai-for-ou-xianhong / distributors-3brain-cellink- zero-coverage / sharma-2026-retinal-organoid-mea-cross-sell) carry forward unchanged. No/personal-logistics.mditem — the vault delta is work-side only.
- Yang are the first LDR files to use the new post-publish vendor-mapping
step. Net-new external evidence in this run (4 paper deep-reads + 1
retrofit commit) — CelVivo/Cellink/Mimetas/3Brain/Femtobiomed product
mapping table is the net-new contribution. Wiki-side: 2 new
automated wiki commits landed in the 2026-08-24T18:05Z →
2026-08-25T18:13Z 24-hour window —
-
This run (2026-08-24, git-repo-1 18:05Z): 5 new vault commits Cells brain organoid review (Wiki.js 1743); (b)
5f02489aKim 2025 Nat Commun EGaIn liquid-metal 3D MEA (Wiki.js 1744); (c)40b357b8Tian 2025 Nat Commun hiPSC epicardium mTOR maturation (Wiki.js 1745); (d)f2118a62Aiello & Bagni 2025 biorxiv Rotating Chamber brain organoid CFD (Wiki.js 1746, CelVivo KB-derived); (e)fb017e4fCelVivo App Note 2026 shear stress ClinoStar vs orbital shaker (Wiki.js 1747). All 5 files landed atobsidian-vault/04-Literature/Deep-Reads/root (not in a per-vendor subfolder — non-standard pattern, see Notable-entity § "2026-08-23 root-level LDR burst"). Vendor-anchor mapping: 3 CelVivo-aligned (App Note + Aiello + Ajongbolo review) + 1 3Brain-adjacent (Kim EGaIn 3D MEA) + 1 cardiac epicardium (Tian mTOR, no vendor callouts). 1 new untracked directory appeared in the working tree this fetch —deepread_40240593/(7 subdirs: 5 PMID-named + 2 slug-named that exactly map to the Aiello + CelVivo App Note papers; the new directory is Robin's LDR pipeline intermediate-artifact workspace, see Notable-entity). The 2 prior untracked directories (celvivo_commercial/+templates/) and theReview/zhou2023_computer_vision_microfluidics.mdfirst-entry-in-Review/-subfolder carry forward unchanged from the prior fetch (now 8-day carry-forward forcelvivo_commercial/+templates/; 13-day carry-forward + 11 fetches silent for theReview/file). Wiki-side: 2 new automated wiki commits landed in the 24-hour window —9cc5e63chore: daily update 2026-08-24 (2026-08-24 02:23 +0800) +127c2dcchore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-24, 2026-08-24 02:30 +0800) — advancing wiki HEAD froma9568d8(2026-08-23T18:11Z fetch) to127c2dc. Both commits are routine auto-orchestration: (a) the9cc5e63daily update carried the synthesis-layer edits from the prior HN-1 2026-08-23T18:00Z + web-search-1 2026-08-23 (skipped) + git-repo-1 2026-08-23T18:11Z runs; the9cc5e63daily update committedsources/git-repo.md+sources/hackernews.md+sources/index.md+sources/openwiki-version-drift.md+sources/web-search.md+themes/05-robin-research.mdfrom the 2026-08-23 dirty set; (b) the127c2dcsources-sync re-applied the count-data wipe pattern on NocoDB / SeaFile / Wiki.js / RAGFlow for the tenth consecutive sources-sync (after 2026-08-152507925+ 2026-08-16997b648+ 2026-08-17be49285+ 2026-08-181fc73ae+ 2026-08-19dcb53a2+ 2026-08-20bd30339+ 2026-08-21f6c2576+ 2026-08-2243d4548+ 2026-08-238f8f767). Net-new external evidence in this run: 5 new paper deep-reads (1 vendor App Note + 4 primary research papers / 1 review / 1 preprint) — all committed tomain. Net-new working-tree artifact:deepread_40240593/pipeline-workspace directory (1 new untracked dir). New commitments added on/commitments.md: (a)celvivo-app-note-2026-clinostar-vs-orbital-shaker-positioning(fold the head-to-head shear-stress comparison into the ClinoStar sales narrative + into the existing CelVivo赋能培训 cluster); (b)aiello-2025-rc-cfd-clinostar-positioning(the < 20 mPa quantitative number is direct ClinoStar value-prop ammunition); (c)kim-2025-egain-3d-mea-vs-3brain-positioning(next-gen HD-MEA field consolidation: Liu 2026 Rogers Lab + Kim 2025 EGaIn + 3Brain Accura-3D); (d)ajongbolo-2025-brain-organoid-review-cluster(pair with the existing Organoids 2026 review to anchor brain-organoid review lane); (e)tian-2025-epicardium-mtor-cardiac-expansion(first cardiac-epicardium paper in deep-read set; no vendor callouts). New themes-row refresh candidate for/themes.mdclass-organoid-3d-bioprintingrow: the 5-paper burst is the largest single-day cluster since 2026-07-29 + breaks the 7-fetch silence; 3 of the 5 papers directly reference CelVivo ClinoStar or 3Brain, validating the recurring-signal evidence footprint. Track on next fetch whether (a) thedeepread_40240593/directory gets committed (currently untracked, 1-day-old); (b) any of the 5 new LDR files get a wiki-side synthesis page (none currently in/sources/literature-*naming pattern). Wiki edits this run: (a)/sources/git-repo.md(this page) — refreshed frontmatter HEAD pointers (vault HEADa4fa5a32→fb017e4f, wiki HEADa9568d8→127c2dc, tags +2026-08-24, timestamp →2026-08-24T18:05:00Z), refreshed the Connector / State section to the new2026-08-24T18-05-31-919Zraw manifest, refreshed the obsidian-vault working-tree-status section to 2026-08-24 (5 new vault commits, 1 new untracked dirdeepread_40240593/,celvivo_commercial/+templates/7-day → 8-day carry-forward,Review/12-day → 13-day + 10 fetches silent → 11 fetches silent), refreshed the openwiki-wiki working-tree-status section to 2026-08-24 (2 new automated wiki commits + 8 uncommitted synthesis-layer edits per the manifestchangedFileslist), added 2 new entries at the top of the Recent-commits-for-vault table (5 new vault commits) + 2 new entries at the top of the Recent-commits-for-wiki table (127c2dcsources-sync 2026-08-249cc5e63daily update 2026-08-24), refreshed the Summary-of-last-48-hours table to add the 2026-08-23T18:11Z → 2026-08-24T18:05Z window data (5 vault commits / 2 wiki commits / operational row noting the tenth consecutive sources-sync re-applying the count-data wipe pattern- the 5-paper LDR burst detail), refreshed the
04-Literature/Deep-Reads/breakdown table (added the root-level 5-file entry + bumpedReview/12 → 13-day +celvivo_commercial/+templates/7 → 8-day carry-forward + total 1,207 → 1,212), added 7 new entries to the Notable-entity section (the 2026-08-23 root-level LDR burst overview + 5 individual paper entries + thedeepread_40240593/pipeline workspace entry), refreshed the Synthesis-policy section with this run's delta summary (the old 2026-08-23 "This run" was demoted to "Previous run (2026-08-23, git-repo-1 18:11Z)" and the new "This run" reflects the 5-paper LDR burst); (b)/themes/05-robin-research.md— vault-snapshot metadata refreshed (fetch timestamp →2026-08-24T18:05:00Z, raw-manifest path → the new2026-08-24T18-05-31-919Zmanifest, HEAD bumpeda4fa5a32→fb017e4f, the 5-paper LDR burst noted in the cluster section, the04-Literature/Deep-Reads/breakdown table updated with the root-level 5-file entry + total 1,207 → 1,212,celvivo_commercial/+templates/7-day → 8-day carry-forward +Review/12-day → 13-day + 10 fetches silent → 11 fetches silent); (c)/commitments.md— added 5 new commitment entries corresponding to the 5 new LDR papers (each with Owner: me + Source: git-repo-1 2026-08-24 + Status: open); (d)/sources/literature.md— added 5 new rows to the "Last 30 days of deep reads" table under a new2026-08-23subsection; (e)/quickstart.md— added this "Latest update — git-repo-1 (2026-08-24T18:05Z)" paragraph; updated the Backlog git-repo entry to reflect the new wiki HEAD127c2dc+ 2 new automated wiki commits + the carry-forward 8 uncommitted synthesis-layer edits - the tenth consecutive sources-sync note + the 5-paper LDR
burst detail; (f)
/sources/README.md— refreshed Active connectors Git repo row + Connector roll Git repo row to mention the 2026-08-24 18:05 UTC fetch + the tenth consecutive sources-sync. No/themes.mdrow change — the 5-paper LDR burst strengthens the existingclass-organoid-3d-bioprintingevidence footprint (3 of 5 papers vendor-aligned to CelVivo + 3Brain) but does not warrant a new theme row at this fetch (single-day burst, no recurrence yet); if a 2026-08-25 fetch surfaces another deep-read cluster, that becomes the recurrence trigger for a theme-row promotion.
-
Previous run (2026-08-23, git-repo-1 18:11Z): 0 new vault commits in the 2026-08-22T18:13Z → 2026-08-23T18:11Z 24-hour window — the vault HEAD is unchanged at
a4fa5a32for the 7th consecutive fetch (the 2026-08-16 Quintard 2024 Nat Commun 4-commit LDR cycle- Guo 2026 Front Cell Dev Biol 3-commit LDR cycle remain the most
recent vault activity, 7 calendar days stale at this fetch).
0 new vault mtime changes — the 2 untracked directories
(
celvivo_commercial/+templates/) and the 23+ untracked files from the 2026-08-17T18:09Z fetch carry forward unchanged. TheReview/zhou2023_computer_vision_microfluidics.mdfirst-entry in the newReview/subfolder is 12-day carry-forward at this fetch (uncommitted since 2026-08-11); the structural signal forReview/continues to weaken per the Notable-entity entry (the subfolder has been a single-entry watchlist since 2026-08-13, now 10 fetches silent). Wiki-side: 2 new automated wiki commits landed in the 24-hour window —8f8f767chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-23, 2026-08-23 02:30 +0800) +a9568d8chore: daily update 2026-08-23 (2026-08-23 02:29 +0800) — advancing wiki HEAD from43d4548(2026-08-22T18:13Z fetch) toa9568d8. Both commits are routine auto-orchestration: (a) thea9568d8daily update carried the synthesis-layer edits from the prior HN-1 2026-08-22T18:00Z + web-search-1 2026-08-22 (skipped) + web-search-1 2026-08-23 (skipped) + git-repo-1 2026-08-22T18:13Z runs; thea9568d8daily update committedsources/git-repo.md+sources/index.md+sources/nocodb.md+sources/ragflow.md+sources/seafile.md sources/wikijs.md+themes/05-robin-research.mdfrom the 2026-08-22 dirty set, reducing the uncommitted-file count from 9 → 6; (b) the8f8f767sources-sync re-applied the count-data wipe pattern on NocoDB / SeaFile / Wiki.js / RAGFlow for the ninth consecutive sources-sync (after 2026-08-152507925+ 2026-08-16997b648+ 2026-08-17be49285+ 2026-08-181fc73ae+ 2026-08-19dcb53a2+ 2026-08-20bd30339+ 2026-08-21f6c2576+ 2026-08-2243d4548). No new external evidence in this run (vault silent), no new theme row, no new commitment row, no new open-question row, no new personal-logistics item — the synthesis layer is unchanged. Wiki edits this run: (a)/sources/git-repo.md(this page) — refreshed frontmatter HEAD pointers (vault HEAD unchanged ata4fa5a32, wiki HEAD43d4548→a9568d8, tags +2026-08-23, timestamp →2026-08-23T18:11:00Z), refreshed the Connector / State section to the new2026-08-23T18-11-34-883Zraw manifest, refreshed the obsidian-vault working-tree-status section to 2026-08-23 (0 new commits, 0 new mtime changes, untracked set unchanged;Review/11-day → 12-day +templates/+celvivo_commercial/6-day → 7-day carry-forward), refreshed the openwiki-wiki working-tree-status section to 2026-08-23 (2 new automated wiki commits + 6 uncommitted synthesis-layer edits, down from 9 at the 2026-08-22T18:13Z fetch becausea9568d8committed 7 of the prior 9 dirty files), added 2 new entries at the top of the Recent-commits-for-wiki table (a9568d8daily update 2026-08-23 +8f8f767sources-sync 2026-08-23), refreshed the Summary-of-last-48-hours table to add the 2026-08-22T18:13Z → 2026-08-23T18:11Z window data (0 vault commits / 2 wiki commits / operational row noting the ninth consecutive sources-sync re-applying the count-data wipe pattern), refreshed the Notable-entityReview/entry (11-day → 12-day carry- forward, 9 fetches silent → 10 fetches silent) + bumpedtemplates/+celvivo_commercial/6-day → 7-day + refreshed the04-Literature/Deep-Reads/breakdown table, refreshed the Synthesis-policy section with this run's delta summary; (b)/themes/05-robin-research.md— vault-snapshot metadata refreshed (fetch timestamp →2026-08-23T18:11:00Z, raw-manifest path → the new2026-08-23T18-11-34-883Zmanifest); the vault HEAD pointer staysa4fa5a32(unchanged across the 2026-08-17 + 2026-08-18 + 2026-08-19 + 2026-08-20 + 2026-08-21 + 2026-08-22 + 2026-08-23 fetches);Review/11-day → 12-day carry-forward;Templates/+CelVivo-commercial/6-day → 7-day; (c)/quickstart.md— added the "Latest update — git-repo-1 (2026-08-23T18:11Z)" paragraph; updated the Backlog git-repo entry to reflect the new wiki HEADa9568d8+ 2 new automated wiki commits + 6 uncommitted synthesis-layer edits (down from 9 at the prior fetch becausea9568d8committed 7 of the prior 9 dirty files) + the ninth consecutive sources-sync note; (d)/sources/README.md— refreshed Active connectors Git repo row + Connector roll Git repo row to mention the 2026-08-23 18:11 UTC fetch + the ninth consecutive sources-sync. No/themes.mdrow change, no/commitments.mdrow, no/open-questions.mdrow, no/personal-logistics.mditem — the vault delta is empty and the wiki delta is automated maintenance only. The "vault is silent on a 24-hour window" pattern continues to be normal cadence for Robin's workflow (the 2026-08-13 + 2026-08-15 + 2026-08-18 + 2026-08-19 + 2026-08-20 + 2026-08-21 + 2026-08-22 fetches were also 0-new-vault-commits daily-cycle follow-ups; the 2026-08-23 fetch makes it 8 consecutive 0-new-vault-commit fetches). The synthesis layer (themes / commitments / open-questions / personal-logistics) is independent of the wiki-side automated maintenance commits.
- Guo 2026 Front Cell Dev Biol 3-commit LDR cycle remain the most
recent vault activity, 7 calendar days stale at this fetch).
0 new vault mtime changes — the 2 untracked directories
(
-
Previous run (2026-08-22, git-repo-1 18:13Z): 0 new vault commits in the 2026-08-21T18:09Z → 2026-08-22T18:13Z 24-hour window — the vault HEAD is unchanged at
a4fa5a32for the 6th consecutive fetch (the 2026-08-16 Quintard 2024 Nat Commun 4-commit LDR cycle- Guo 2026 Front Cell Dev Biol 3-commit LDR cycle remain the most
recent vault activity, 6 calendar days stale at this fetch).
0 new vault mtime changes — the 2 untracked directories
(
celvivo_commercial/+templates/) and the 23+ untracked files from the 2026-08-17T18:09Z fetch carry forward unchanged. TheReview/zhou2023_computer_vision_microfluidics.mdfirst-entry in the newReview/subfolder is 11-day carry-forward at this fetch (uncommitted since 2026-08-11); the structural signal forReview/continues to weaken per the Notable-entity entry (the subfolder has been a single-entry watchlist since 2026-08-13, now 9 fetches silent). Wiki-side: 2 new automated wiki commits landed in the 24-hour window —d8e2277chore: daily update 2026-08-22 (2026-08-22 02:23 +0800) +43d4548chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-22, 2026-08-22 02:30 +0800) — advancing wiki HEAD fromf6c2576(2026-08-21T18:09Z fetch) to43d4548. Both commits are routine auto-orchestration: (a) thed8e2277daily update carried the synthesis-layer edits from the prior HN-1 2026-08-22T18:00Z + web-search-1 2026-08-22 (skipped) + git-repo-1 2026-08-21T18:09Z runs; (b) the43d4548sources-sync re-applied the count-data wipe pattern on NocoDB / SeaFile / Wiki.js / RAGFlow for the eighth consecutive sources-sync (after 2026-08-152507925+ 2026-08-16997b648+ 2026-08-17be49285+ 2026-08-181fc73ae+ 2026-08-19dcb53a2+ 2026-08-20bd30339+ 2026-08-21f6c2576). No new external evidence in this run (vault silent), no new theme row, no new commitment row, no new open-question row, no new personal-logistics item — the synthesis layer is unchanged. Wiki edits this run: (a)/sources/git-repo.md(this page) — refreshed frontmatter HEAD pointers (vault HEAD unchanged ata4fa5a32, wiki HEADf6c2576→43d4548, tags +2026-08-22, timestamp →2026-08-22T18:13:00Z), refreshed the Connector / State section to the new2026-08-22T18-13-00-193Zraw manifest, refreshed the obsidian-vault working-tree-status section to 2026-08-22 (0 new commits, 0 new mtime changes, untracked set unchanged;Review/10-day → 11-day +templates/+celvivo_commercial/5-day → 6-day carry-forward), refreshed the openwiki-wiki working-tree-status section to 2026-08-22 (2 new automated wiki commits + 9 uncommitted synthesis-layer edits, the same dirty count as the 2026-08-21T18:09Z fetch), added 2 new entries at the top of the Recent-commits-for-wiki table (43d4548sources-sync 2026-08-22 +d8e2277daily update 2026-08-22), refreshed the Summary-of-last-48-hours table to add the 2026-08-21T18:09Z → 2026-08-22T18:13Z window data (0 vault commits / 2 wiki commits / operational row noting the eighth consecutive sources-sync re-applying the count-data wipe pattern), refreshed the Notable-entityReview/entry (10-day → 11-day carry- forward, 8 fetches silent → 9 fetches silent) + bumpedtemplates/+celvivo_commercial/5-day → 6-day, refreshed the Synthesis-policy section with this run's delta summary; (b)/themes/05-robin-research.md— vault-snapshot metadata refreshed (fetch timestamp →2026-08-22T18:13:00Z, raw-manifest path → the new2026-08-22T18-13-00-193Zmanifest); the vault HEAD pointer staysa4fa5a32(unchanged across the 2026-08-17 + 2026-08-18 + 2026-08-19 + 2026-08-20 + 2026-08-21 + 2026-08-22 fetches);Review/10-day → 11-day carry-forward;Templates/+CelVivo-commercial/5-day → 6-day; (c)/quickstart.md— added the "Latest update — git-repo-1 (2026-08-22T18:13Z)" paragraph; updated the Backlog git-repo entry to reflect the new wiki HEAD43d4548+ 2 new automated wiki commits + 9 uncommitted synthesis-layer edits (same count as prior fetch) + the eighth consecutive sources-sync note; (d)/sources/README.md— refreshed Active connectors Git repo row + Connector roll Git repo row to mention the 2026-08-22 18:13 UTC fetch + the eighth consecutive sources-sync. No/themes.mdrow change, no/commitments.mdrow, no/open-questions.mdrow, no/personal-logistics.mditem — the vault delta is empty and the wiki delta is automated maintenance only. The "vault is silent on a 24-hour window" pattern continues to be normal cadence for Robin's workflow (the 2026-08-13 + 2026-08-15 + 2026-08-18 + 2026-08-19 + 2026-08-20 + 2026-08-21 fetches were also 0-new-vault-commits daily-cycle follow-ups; the 2026-08-22 fetch makes it 7 consecutive 0-new-vault-commit fetches). The synthesis layer (themes / commitments / open-questions / personal-logistics) is independent of the wiki-side automated maintenance commits.
- Guo 2026 Front Cell Dev Biol 3-commit LDR cycle remain the most
recent vault activity, 6 calendar days stale at this fetch).
0 new vault mtime changes — the 2 untracked directories
(
-
Previous run (2026-08-21, git-repo-1 18:09Z): 0 new vault commits in the 2026-08-20T18:09Z → 2026-08-21T18:09Z 24-hour window — the vault HEAD is unchanged at
a4fa5a32for the 5th consecutive fetch (the 2026-08-16 Quintard 2024 Nat Commun 4-commit LDR cycle- Guo 2026 Front Cell Dev Biol 3-commit LDR cycle remain the most
recent vault activity, 5 calendar days stale at this fetch).
0 new vault mtime changes — the 2 untracked directories
(
celvivo_commercial/+templates/) and the 23+ untracked files from the 2026-08-17T18:09Z fetch carry forward unchanged. TheReview/zhou2023_computer_vision_microfluidics.mdfirst-entry in the newReview/subfolder is 10-day carry-forward at this fetch (uncommitted since 2026-08-11); the structural signal forReview/continues to weaken per the Notable-entity entry (the subfolder has been a single-entry watchlist since 2026-08-13, now 8 fetches silent). Wiki-side: 2 new automated wiki commits landed in the 24-hour window —b6dc337chore: daily update 2026-08-21 (2026-08-21 02:27 +0800) +f6c2576chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-21, 2026-08-21 02:30 +0800) — advancing wiki HEAD frombd30339(2026-08-20T18:09Z fetch) tof6c2576. Both commits are routine auto-orchestration: (a) theb6dc337daily update carried the synthesis-layer edits from the prior HN-1 2026-08-21T18:00Z + web-search-1 2026-08-21 (skipped) + git-repo-1 2026-08-20T18:09Z runs; theb6dc337daily update committedsources/index.mdfrom the 2026-08-20 dirty set (reducing uncommitted-file count from 10 → 9 at this fetch); (b) thef6c2576sources-sync re-applied the count-data wipe pattern on NocoDB / SeaFile / Wiki.js / RAGFlow for the seventh consecutive sources-sync (after 2026-08-152507925+ 2026-08-16997b648+ 2026-08-17be49285+ 2026-08-181fc73ae+ 2026-08-19dcb53a2+ 2026-08-20bd30339). No new external evidence in this run (vault silent), no new theme row, no new commitment row, no new open-question row, no new personal-logistics item — the synthesis layer is unchanged. Wiki edits this run: (a)/sources/git-repo.md(this page) — refreshed frontmatter HEAD pointers (vault HEAD unchanged ata4fa5a32, wiki HEADdcb53a2→bd30339, tags +2026-08-20, timestamp →2026-08-20T18:09:15Z), refreshed the Connector / State section to the new2026-08-20T18-09-15-122Zraw manifest, refreshed the obsidian-vault working-tree-status section to 2026-08-20 (0 new commits, 0 new mtime changes, untracked set unchanged;Review/8-day → 9-day +templates/+celvivo_commercial/3-day → 4-day carry-forward), refreshed the openwiki-wiki working-tree-status section to 2026-08-20 (2 new automated wiki commits + the carry-forward 10 uncommitted synthesis-layer edits), added 2 new entries at the top of the Recent-commits-for-wiki table (bd30339sources-sync 2026-08-20 +a44f284daily update 2026-08-20), refreshed the Summary-of-last-48-hours table to add the 2026-08-19T18:08Z → 2026-08-20T18:09Z window data (0 vault commits / 2 wiki commits / operational row noting the sixth consecutive sources-sync re-applying the count-data wipe pattern), refreshed the Notable-entityReview/entry (8-day → 9-day carry- forward, 6 fetches silent → 7 fetches silent) + bumpedtemplates/+celvivo_commercial/3-day → 4-day, refreshed the Synthesis-policy section with this run's delta summary; (b)/themes/05-robin-research.md— vault-snapshot metadata refreshed (fetch timestamp →2026-08-20T18:09:15Z, raw-manifest path → the new2026-08-20T18-09-15-122Zmanifest); the vault HEAD pointer staysa4fa5a32(unchanged across the 2026-08-17 + 2026-08-18 + 2026-08-19 + 2026-08-20 fetches);Review/8-day → 9-day carry-forward;Templates/+CelVivo-commercial/3-day → 4-day; (c)/quickstart.md— added the "Latest update — git-repo-1 (2026-08-20T18:09Z)" paragraph; updated the Backlog git-repo entry to reflect the new wiki HEADbd30339+ 2 new automated wiki commits + the carry-forward 10 uncommitted files + the sixth consecutive sources-sync note; (d)/sources/README.md— refreshed Active connectors Git repo row + Connector roll Git repo row to mention the 2026-08-20 18:09 UTC fetch + the sixth consecutive sources-sync. No/themes.mdrow change, no/commitments.mdrow, no/open-questions.mdrow, no/personal-logistics.mditem — the vault delta is empty and the wiki delta is automated maintenance only. The "vault is silent on a 24-hour window" pattern continues to be normal cadence for Robin's workflow (the 2026-08-13 + 2026-08-15 + 2026-08-18 + 2026-08-19 fetches were also 0-new-vault-commits daily-cycle follow-ups; the 2026-08-20 fetch makes it 5 consecutive 0-new-vault-commit fetches). The synthesis layer (themes / commitments / open-questions / personal-logistics) is independent of the wiki-side automated maintenance commits.
- Guo 2026 Front Cell Dev Biol 3-commit LDR cycle remain the most
recent vault activity, 5 calendar days stale at this fetch).
0 new vault mtime changes — the 2 untracked directories
(
-
Previous run (2026-08-19, git-repo-1 18:08Z): 0 new vault commits in the 2026-08-18T18:10Z → 2026-08-19T18:08Z 24-hour window — the vault HEAD is unchanged at
a4fa5a32for the 3rd consecutive fetch (the 2026-08-16 Quintard 2024 Nat Commun 4-commit LDR cycle- Guo 2026 Front Cell Dev Biol 3-commit LDR cycle remain the most
recent vault activity, 3 calendar days stale at this fetch).
0 new vault mtime changes — the 2 untracked directories
(
celvivo_commercial/+templates/) and the 23+ untracked files from the 2026-08-17T18:09Z fetch carry forward unchanged. TheReview/zhou2023_computer_vision_microfluidics.mdfirst-entry in the newReview/subfolder is 8-day carry-forward at this fetch (uncommitted since 2026-08-11); the structural signal forReview/continues to weaken per the Notable-entity entry (the subfolder has been a single-entry watchlist since 2026-08-13, now 6 fetches silent). Wiki-side: 2 new automated wiki commits landed in the 24-hour window —7e904ecchore: daily update 2026-08-19 (2026-08-19 02:23 +0800) +dcb53a2chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-19, 2026-08-19 02:30 +0800) — advancing wiki HEAD from1fc73ae(2026-08-18T18:10Z fetch) todcb53a2. Both commits are routine auto-orchestration: (a) the7e904ecdaily update carried the synthesis-layer edits from the prior HN-1 2026-08-19T18:00Z + web-search-1 2026-08-19 + git-repo-1 2026-08-18T18:10Z runs (touching.last-update.json+quickstart.md+sources/{README,git-repo,hackernews,index,nocodb,ragflow,seafile,web-search,wikijs}.md themes/05-robin-research.mdpergit show --stat 7e904ec); (b) thedcb53a2sources-sync re-applied the count-data wipe pattern on NocoDB / SeaFile / Wiki.js / RAGFlow for the fifth consecutive sources-sync (after 2026-08-152507925+ 2026-08-16997b648+ 2026-08-17be49285+ 2026-08-181fc73ae). No new external evidence in this run (vault silent), no new theme row, no new commitment row, no new open-question row, no new personal-logistics item — the synthesis layer is unchanged. Wiki edits this run: (a)/sources/git-repo.md(this page) — refreshed frontmatter HEAD pointers (vault HEAD unchanged ata4fa5a32, wiki HEAD1fc73ae→dcb53a2, tags +2026-08-19, timestamp →2026-08-19T18:08:24Z), refreshed the Connector / State section to the new2026-08-19T18-08-24-164Zraw manifest, refreshed the obsidian-vault working-tree-status section to 2026-08-19 (0 new commits, 0 new mtime changes, untracked set unchanged), refreshed the openwiki-wiki working-tree-status section to 2026-08-19 (2 new automated wiki commits + the carry-forward 10 uncommitted synthesis-layer edits —sources/index.mdre-appears as dirty in the working tree at this fetch), added 2 new entries at the top of the Recent-commits-for-wiki table (dcb53a2+7e904ec), refreshed the Summary-of-last-48-hours table to add the 2026-08-18T18:10Z → 2026-08-19T18:08Z window data (0 vault commits / 2 wiki commits / operational row noting the fifth consecutive sources-sync re-applying the count-data wipe pattern), refreshed the Synthesis-policy section with this run's delta summary; (b)/themes/05-robin-research.md— vault-snapshot metadata refreshed (fetch timestamp →2026-08-19T18:08:24Z, raw-manifest path → the new2026-08-19T18-08-24-164Zmanifest); the vault HEAD pointer staysa4fa5a32(unchanged across the 2026-08-17 + 2026-08-18 + 2026-08-19 fetches); (c)/quickstart.md— added the "Latest update — git-repo-1 (2026-08-19T18:08Z)" paragraph; updated the Backlog git-repo entry to reflect the new wiki HEADdcb53a2+ 2 new automated wiki commits + the carry-forward 10 uncommitted files + the fifth consecutive sources-sync note. No/themes.mdrow change, no/commitments.mdrow, no/open-questions.mdrow, no/personal-logistics.mditem — the vault delta is empty and the wiki delta is automated maintenance only. The "vault is silent on a 24-hour window" pattern continues to be normal cadence for Robin's workflow (the 2026-08-13 + 2026-08-15 + 2026-08-18 fetches were also 0-new-vault-commits daily-cycle follow-ups; the 2026-08-19 fetch made it 4 consecutive 0-new-vault-commit fetches). The synthesis layer (themes / commitments / open-questions / personal-logistics) is independent of the wiki-side automated maintenance commits.
- Guo 2026 Front Cell Dev Biol 3-commit LDR cycle remain the most
recent vault activity, 3 calendar days stale at this fetch).
0 new vault mtime changes — the 2 untracked directories
(
-
Previous run (2026-08-18, git-repo-1 18:10Z): 0 new vault commits in the 2026-08-17T18:09Z → 2026-08-18T18:10Z 24-hour window — the vault HEAD is unchanged at
a4fa5a32(the 2026-08-16 Quintard 2024 Nat Commun 4-commit LDR cycle + Guo 2026 Front Cell Dev Biol 3-commit LDR cycle remain the most recent vault activity, 2 calendar days stale at this fetch). 0 new vault mtime changes — the 2 untracked directories (celvivo_commercial/+templates/) and the 23+ untracked files from the 2026-08-17T18:09Z fetch carry forward unchanged. TheReview/zhou2023_computer_vision_microfluidics.mdfirst-entry in the newReview/subfolder is 7-day carry-forward at this fetch (uncommitted since 2026-08-11); the structural signal forReview/continues to weaken per the Notable-entity entry (the subfolder has been a single-entry watchlist since 2026-08-13). Wiki-side: 2 new automated wiki commits landed in the 24-hour window —8127797chore: daily update 2026-08-18 (2026-08-18 02:23 +0800) +1fc73aechore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-18, 2026-08-18 02:30 +0800) — advancing wiki HEAD frombe49285(2026-08-17T18:09Z fetch) to1fc73ae. Both commits are routine auto-orchestration: (a) the8127797daily update carried the synthesis-layer edits from the prior HN-1 2026-08-18T18:00Z run + this git-repo-1 2026-08-17T18:09Z run (touchingcommitments.md+index.md+quickstart.md+sources/{README,git-repo,hackernews,index,literature,nocodb,ragflow,seafile,web-search,wikijs}.mdthemes/{01-organoid-equipment,05-robin-research}.mdpergit show --stat 8127797); (b) the1fc73aesources-sync re-applied the count-data wipe pattern on NocoDB / SeaFile / Wiki.js / RAGFlow for the fourth consecutive sources-sync (after 2026-08-152507925+ 2026-08-16997b648+ 2026-08-17be49285). No new external evidence in this run (vault silent), no new theme row, no new commitment row, no new open-question row, no new personal-logistics item — the synthesis layer is unchanged. Wiki edits this run: (a)/sources/git-repo.md(this page) — refreshed frontmatter HEAD pointers (vault HEAD unchanged ata4fa5a32, wiki HEADbe49285→1fc73ae, tags +2026-08-18, timestamp →2026-08-18T18:10:12Z), refreshed the Connector / State section to the new2026-08-18T18-10-12-916Zraw manifest, refreshed the obsidian-vault working-tree-status section to 2026-08-18 (0 new commits, 0 new mtime changes, untracked set unchanged), refreshed the openwiki-wiki working-tree-status section to 2026-08-18 (2 new automated wiki commits + the carry-forward 9 uncommitted synthesis-layer edits), added 2 new entries at the top of the Recent-commits-for-wiki table (1fc73ae+8127797), refreshed the Summary-of-last-48-hours table to add the 2026-08-17T18:09Z → 2026-08-18T18:10Z window data (0 vault commits / 2 wiki commits / operational row noting the fourth consecutive sources-sync re-applying the count-data wipe pattern), refreshed the Synthesis-policy section with this run's delta summary; (b)/themes/05-robin-research.md— vault-snapshot metadata refreshed (fetch timestamp →2026-08-18T18:10:12Z, raw-manifest path → the new2026-08-18T18-10-12-916Zmanifest); the vault HEAD pointer staysa4fa5a32(unchanged across both 2026-08-17 and 2026-08-18 fetches); (c)/quickstart.md— added the "Latest update — git-repo-1 (2026-08-18T18:10Z)" paragraph; updated the Backlog git-repo entry to reflect the new wiki HEAD1fc73ae+ 2 new automated wiki commits + the carry-forward 9 uncommitted files + the fourth consecutive sources-sync note. No/themes.mdrow change, no/commitments.mdrow, no/open-questions.mdrow, no/personal-logistics.mditem — the vault delta is empty and the wiki delta is automated maintenance only. The "vault is silent on a 24-hour window" pattern continues to be normal cadence for Robin's workflow (the 2026-08-13 fetch was also a 0-new-vault-commits daily-cycle follow-up; the 2026-08-15 fetch was also a 0-new-vault- commits daily-cycle follow-up). The synthesis layer (themes / commitments / open-questions / personal-logistics) is independent of the wiki-side automated maintenance commits.
-
Previous run (2026-08-17, git-repo-1 18:09Z): 7 new vault commits landed in the 2026-08-15T18:07Z → 2026-08-17T18:09Z window — the vault HEAD bumped from
297f106d(the 2026-08-12 Liang 2026 cluster) toa4fa5a32(the 2026-08-16 Quintard 2024 + Guo 2026 cluster). The cluster breaks down as: (a) Quintard 2024 Nat Commun 4-commit LDR cycle (0fc8db24adds 189 lines →290e9635-v2 修图床/双 H1/落款 →24c713de-v3 Wiki.js 自带图床 6 张图 →4073abf4-v4 转发语标题/ 落款加粗/删 3Brain) onobsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md; (b) Guo 2026 Front Cell Dev Biol 3-commit LDR cycle (2e6f5989adds 170 lines →00f824f2-v2 修图床 (加 2 张 Wiki.js 自带图) →a4fa5a32-v3 补 Fig 1) onobsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md. The 2026-08-16 cluster is the first time since the 2026-07-28 / 2026-07-29 Parate / Lee / Hodge cluster that two new paper deep-reads landed onmainin the same 48-hour window, and the first time a review-type IRB / ethics systematic review (Guo 2026) was deep-read in any vault window. 2 new untracked directories appeared in the working tree this fetch: (a)celvivo_commercial/1331651_20260630_131201.pdf(the 6-30 quote PDF migrated into a new folder); (b)templates/类器官IRB申请清单.md(the IRB application checklist Robin produced from the Guo 2026 review — Robin's first customer-facing sales ammunition template derived from a single deep-read). The 23 untracked working-tree files from the 2026-08-13 fetch are unchanged at this fetch (theReview/zhou2023_computer_vision_microfluidics.mdfirst-entry-in-Review/-subfolder is still untracked, now a 4-day carry-forward with watchlist signal weakening per the Notable-entity entry). Wiki-side: 4 new wiki commits landed (151d22bdaily update 2026-08-16 +997b648sources-sync 2026-08-16 +5c70881daily update 2026-08-17 (created the newsources/openwiki-version-drift.mdauto-generated page) +be49285sources-sync 2026-08-17), advancing HEAD from2507925(2026-08-15) tobe49285(2026-08-17). 9 dirty wiki files in the working tree (.last-update.json+quickstart.md+sources/README.md+sources/hackernews.md+sources/nocodb.mdsources/ragflow.md+sources/seafile.md+sources/web-search.mdsources/wikijs.md) are accumulated synthesis-layer edits from the prior HN-1 2026-08-15 + HN-1 2026-08-16 + HN-1 2026-08-17 + web-search-1 2026-08-15 + web-search-1 2026-08-17 + git-repo-1 2026-08-15 runs that are pending the next CLI orchestration commit (down from 10 dirty files at the 2026-08-15 fetch —sources/index.mdgot committed in the151d22b2026-08-16 daily update). One new wiki file added in the window:sources/openwiki-version-drift.md(auto-generated OpenWiki version drift monitor; reportsv0.3.1local →v0.3.3npm latest as of 2026-08-15T20:00:03Z with a manualnpm install -g openwiki@latestaction and a WARNING that v0.3.1 → v0.4+ may have breaking changes; the page is informational, not a synthesis target). No/commitments.mdrow, no/open-questions.mdrow, no/personal-logistics.mditem added this run beyond the canonical synthesis pipeline — the Quintard 2024 deep-read has no existing synthesis page yet (the deep-read pipeline currently only carriesliang-2026-celvivo-clinostar-positioningmiao-2025-celvivo-clinostar-positioning+liu-2026-hd-mea-roadmap-implicationsharma-2026-retinal-organoid-mea-cross-sell); the Guo 2026 IRB review is the first ethics-side deep-read and the IRB checklist template is the first customer-facing sales ammunition template, both of which warrant a commitment + a synthesis page on a future fetch. Wiki edits this run: (a)/sources/git-repo.md(this page) — refreshed frontmatter HEAD pointers (vault HEAD297f106d→a4fa5a32, wiki HEAD2507925→be49285, tags +2026-08-17, timestamp →2026-08-17T18:09:32Z), refreshed the Connector / State section to the new2026-08-17T18-09-32-895Zraw manifest, refreshed the obsidian-vault working-tree-status section to 2026-08-17 (7 new vault commits, 2 new untracked dirs, theReview/zhou2023_computer_vision_microfluidics.mdcarries forward as still-untracked), refreshed the Recent-commits-for-vault table to put the 7 new 2026-08-16 commits on top of the 2026-08-12 cluster, refreshed the openwiki-wiki working-tree-status section to 2026-08-17 (4 new wiki commits + 9 uncommitted synthesis-layer edits —sources/index.mdgot committed in151d22b), refreshed the Recent-commits-for-wiki table to put the 4 new 2026-08-16/2026-08-17 commits on top of the 2026-08-15 cluster, refreshed the Summary-of-last-48-hours table to add the 2026-08-15T18:07Z → 2026-08-17T18:09Z window data (7 vault commits / 4 wiki commits / 9 uncommitted wiki files / 1 new wiki file + 2 new untracked dirs + 4-day carry-forward onReview/subfolder), refreshed the Notable-entity section to add (a) "Quintard 2024 microfluidic vascularized organoid chip" entry (with 4-star Mimetas/CelVivo/Emulate mapping), (b) "Guo 2026 organoid ethics systematic review" entry (with 4-star Mimetas/CelVivo/Emulate mapping + IRB checklist template cross-link), (c) refreshed "Review/ subfolder" entry with watchlist-trigger-met note, (d) new "templates/ subfolder" entry (first customer-facing sales ammunition template), (e) new "celvivo_commercial/ subfolder" entry (the 6-30 quote PDF migration), refreshed the Synthesis-policy section with this run's delta summary. No/themes.mdrow change — the new external evidence routes into the existingclass-organoid-3d-bioprintingtheme row (Quintard 2024 is organ-on-chip adjacent to Robin's 4 application domains; Guo 2026 is IRB-side adjacent to the same row); the Robin-authored IRB checklist template routes into the existing/themes/05-robin-research.md"Sales ammunition pipeline" section rather than a new theme row. No/open-questions.mdrow, no/personal-logistics.mditem — the IRB checklist is a vendor-anchored customer-training artifact, not a memory-graph uncertainty. (b)/themes/05-robin-research.md— vault-snapshot metadata refreshed (fetch timestamp →2026-08-17T18:09:32Z, raw-manifest path → the new2026-08-17T18-09-32-895Zmanifest; vault HEAD297f106d→a4fa5a32; untracked-dir set refreshed withcelvivo_commercial/+templates/entries;04-Literature/Deep-Reads/Organoid/count659→661(Quintard + Guo); 30-day research output table extended with the 2026-08-16 Quintard 2024 + Guo 2026 row; by-vendor table extended withMicrofluidic / organ-on-chip adjacentandEthics / IRBrows; Sales ammunition pipeline section extended with thetemplates/类器官IRB申请清单.mdIRB checklist template). (c)/themes/01-organoid-equipment.md— Quintard 2024 added to CelVivo evidence anchors (CelVivo ClinoStar rating 3 upstream workflow step) and Guo 2026 added to the Regulatory / China-specific context section (CelVivo ClinoStar rating 4 IRB compliance ammunition; companion to the existing CDE classification- Order No. 818 items). (d)
/sources/literature.md— Quintard 2024 - Guo 2026 added to the 30-day deep-read index. (e)
/sources/README.md— git-repo last-updated refreshed from2026-08-15 18:07 UTCto2026-08-17 18:09 UTC. (f)/quickstart.md— added the "Latest update — git-repo-1 (2026-08-17T18:09Z)" paragraph. Wiki-side: 4 new wiki commits landed (021e929daily update 2026-08-14 +6258717sources-sync 2026-08-14 +173b58cdaily update 2026-08-15 +2507925sources-sync 2026-08-15), advancing HEAD from1737454(2026-08-13) to2507925(2026-08-15). One operational issue was surfaced by2507925: the 2026-08-15 sources-sync committed empty count values for NocoDB / SeaFile / Wiki.js / RAGFlow (NocoDB 6614 → 0, Wiki.js 83 → 0, RAGFlow landing 200 → 000) — see Notable-entity § "2026-08-15 sources-sync bug" below. 10 dirty wiki files in the working tree (.last-update.json+quickstart.md+sources/README.md+sources/hackernews.md+sources/index.md+sources/nocodb.md+sources/ragflow.md+sources/seafile.md+sources/web-search.md sources/wikijs.md) are accumulated synthesis-layer edits from the prior HN-1 2026-08-13 + HN-1 2026-08-15 + web-search-1 2026-08-15 + this git-repo-1 2026-08-15 runs that are pending the next CLI orchestration commit. Wiki edits this run: (a)/sources/git-repo.md(this page) — refreshed frontmatter HEAD pointers (vault HEAD unchanged, wiki HEAD1737454→2507925, tags +2026-08-15, timestamp →2026-08-15T18:07:49Z), refreshed the Connector / State section to the new2026-08-15T18-07-49-711Zraw manifest, refreshed the obsidian-vault working-tree-status section to 2026-08-15 (no new untracked files; theReview/zhou2023_computer_vision_microfluidics.mdcarries forward as still-untracked), refreshed the openwiki-wiki working-tree-status section to 2026-08-15 (4 new wiki commits + 10 uncommitted synthesis-layer edits + the count-data wipe surfaced in the Notable-entity section), refreshed the recent-commits table with the 4 new wiki commits on top of the prior 2026-08-13 cluster, refreshed the Summary-of-last-24-hours table with the 2026-08-13 → 2026-08-15 window data (0 vault commits / 4 wiki commits / 10 uncommitted wiki files / operational issue row), refreshed the Notable-entity section to add a "2026-08-15 sources-sync bug" entry + carry-forward note on theReview/subfolder entry, refreshed the synthesis-policy section with this run's delta summary- the operational-issue observation; (b)
/themes/05-robin-research.md— vault-snapshot metadata refreshed (fetch timestamp →2026-08-15T18:07:49Z, raw-manifest path → the new2026-08-15T18-07-49-711Zmanifest); the vault HEAD pointer stays297f106d(unchanged across both 2026-08-13 and 2026-08-15 fetches); (c)/quickstart.md— added the "Latest update — git-repo-1 (2026-08-15T18:07Z)" paragraph ahead of the current "Latest update — web-search-1 attempted 2026-08-15 skipped" paragraph; demoted the web-search-1 paragraph to a prior-run reference; updated the Backlog git-repo entry to reflect the new wiki HEAD2507925+ 4 new wiki commits + 10 uncommitted files + the operational issue note. No/commitments.mdrow, no/open-questions.mdrow, no/personal-logistics.mditem, no/themes.mdrow change — the vault delta is empty (no new commits, no new untracked files), and the existing 2026-08-12 Liang 2026 commitment /class-organoid-3d-bioprintingtheme row already cover the structural evidence.
-
Previous run (2026-08-13, git-repo-1 18:08Z): 0 new vault commits in the 24-hour window — the vault HEAD was unchanged at
297f106d(the 2026-08-12 Liang 2026 4-commit LDR cluster remained the most recent vault activity). The only vault-side delta was 1 new untracked file:04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md— the first entry in a newReview/subfolder under04-Literature/Deep-Reads/(see Notable-entity entry above). 1 noise file (__pycache__/...pyc) was ignored. Wiki-side: 2 new wiki commits landed (8ddc6d9daily update 2026-08-13 +1737454sources-sync 2026-08-13), advancing HEAD fromc57ead4(2026-08-12) to1737454(2026-08-13). 8 dirty wiki files in the working tree were synthesis-layer edits from the prior HN-1 2026-08-13 run that landed after1737454committed and were pending the next CLI orchestration commit. -
Previous run (2026-08-12, git-repo-1 18:08Z): 4 new vault commits on the same single Liang 2026 Sci Rep liver organoid paper walked through Robin's standard 3-stage LDR cycle (
e542c977adds file →8699a154page 946 9 项 SOP 重写版 →aacba7aa+297f106dpage 934 修齐 micro-revisions) — this was the net-new external evidence for that run. Wiki edits at that time are described in the synthesis-policy paragraph above; the canonical synthesis continues to live at/themes/01-organoid-equipment.md,/themes/05-robin-research.md, and/commitments.mdliang-2026-celvivo-clinostar-positioning. -
The vault is a knowledge base, not a live signal stream; durable per-document synthesis (paper deep reads, sales scripts, customer files) requires reading individual files, which is delegated to the Hermes skill and RAGFlow.
-
Future runs should keep this page structural. Promote a row to a canonical theme only when the connector observes a recurring workflow (e.g. weekly literature digest cadence, sales training iteration pattern) across multiple fetches.
-
Process signal worth watching (2026-08-13): (a) New
Review/subfolder signal — Robin added a 20th subfolder under04-Literature/Deep-Reads/dedicated to review-type papers, withzhou2023_computer_vision_microfluidics.mdas the first entry. If the subfolder accumulates ≥3 entries, this signals a formal review-paper stream is being built separately from the original-research stream; if it stays at 1 entry, it's a one-off. (b) Liang 2026's MOC linkage confirms the MOC pattern is in active use — the paper'srelated:field already names[[MOC-类器官与3D培养]](the first MOC, created 2026-08-10) on the day of publication, not a future-state plan. Track on the next git-repo fetch whether more papers acquire MOCrelated:back-links and whether MOC-3Brain-HD-MEA / MOC-Cellink-BIO-X land. (c) Page 934 修齐 micro-revisions now appear on every new LDR cycle —297f106dis the second paper (after381fcbaaOVB-organoids 2026-08-11) where Robin applied the H1 去括号 / 元数据 bold / 📄PDF 文件名 alignment. The pattern appears to be the new standard end-state. (d) Phase A frontmatter batch rollout is still paused (only 6 of ~1,204 deep-reads received the 6-field frontmatter); no progress this run.
Next update
Run openwiki_ingest_connector connectorId=git-repo (or
openwiki personal --update) to refresh. Expect HEAD bump, refreshed
recentCommits, and updated working-tree status.
rking-tree status.