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OpenWiki Bot 81ac94a1dc chore: daily update 2026-08-26

2026-08-26 02:25:45 +08:00

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Commitments

Concrete work tasks, follow-ups, approvals, and scheduled items extracted from Gmail, Notion, Slack, direct mentions, and other work-relevant sources. Personal errands and life admin live in /personal-logistics.md instead.

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china-cde-cell-gene-therapy-rules-2026: verify CDE classification scope for Chinese pharma / CDMO conversations

Owner: me
Source: web-search — cisema.com 2026-07-24 (China CDE Defines Classification Rules for Cell & Gene Therapy Drugs)
Due: unscheduled
Status: open
Notes: Single credible regulatory-trade source. Pull the NMPA/CDE-direct release before the next vendor sync; check whether any active CellShot-TriArm or ClinoReactor-class deals depend on the new classification scope.

celvivo-clinoreactor-thewell-bioscience-xeno-free: verify TheWell Bioscience co-marketing signal on next CelVivo check

Owner: me
Source: web-search — thewellbio.com 2026-07-21 / 2026-07-23 / 2026-07-25 (Xeno-Free Cell Culture Media, Stem Cell Culture Product Guide, Apical-Out Organoids white paper — all explicitly name "CelVivo ClinoReactor™")
Due: unscheduled
Status: open
Notes: First vendor-anchored CelVivo ClinoReactor signal in any Tavily pull (prior pulls returned only MO:BOT / generic organoid). TheWell Bioscience is a hydrogel-media partner; their workflow pages position ClinoReactor as the scale-up vessel for apical-out organoids + hMSC expansion. Confirm with CelVivo whether this is a sanctioned co-marketing arrangement and whether it maps to any active Chinese pharma / CDMO deal.

china-order-no-818-clinical-translation: verify Order No. 818 (effective 2026-05-01) scope for Chinese pharma / CDMO conversations

Owner: me
Source: web-search — BetaLife LinkedIn 2026-07 (top score 0.779; explicitly cites "Order No. 818, effective May 1, 2026" with accelerated clinical-translation pathway); Tavily answer text corroborates; Roots Analysis re-mentions broader China cell-therapy regulatory pattern
Due: unscheduled
Status: open
Notes: Single primary source (BetaLife SG LinkedIn) but the regulation itself is a published policy text — Order No. 818 creates an accelerated clinical-translation pathway at qualified hospitals for cell therapy and 3D bioprinting after demonstrating safety and preliminary efficacy. This is the clinical-translation counterpart to the existing china-cde-cell-gene-therapy-rules-2026 item (which is about classification / CMC planning). Both items matter: classification scope drives dossier content vendors need to assemble; the clinical-translation pathway drives which hospitals can host first-in-human studies. Pull the NMPA / State Council Order No. 818 direct text before the next vendor sync; check whether any active CellShot-TriArm or ClinoReactor-class deal depends on whether the buyer hospital qualifies as a "qualified hospital" under the regulation.

cellink-bio-x-gen3-customer-evidence: verify Cellink BIO X Gen 3 / BIO X6 customer pipeline on next Cellink check

Owner: me
Source: web-search — Nuclear Mechano-Oncology LinkedIn 2026-07 (score 0.601; "our new BIO X Gen 3 bioprinter has now been installed … first hands-on training session"); CELLINK official LinkedIn 2026-07-28 (score 0.287; BIO X6 at University of Miami 3D Bioprinting Facility); third-party market report LinkedIn 2026-07-28 (score 0.659; Cellink revenue uptick following strategic acquisitions); appellaser.ro practical selection guide 2026-07-24 (score 0.303; BIO X Gen 3 general-purpose positioning)
Due: unscheduled
Status: open
Notes: First vendor-anchored Cellink signal in any Tavily pull after 5 prior pulls of zero Cellink product mentions. Four distinct sources: customer install LinkedIn (Eastern Europe), vendor LinkedIn (CELLINK U. Miami), market report, independent selection guide. Verify with Cellink whether the BIO X Gen 3 / BIO X6 nomenclature is current product naming or if one is being deprecated; whether any of the named customer accounts (Nuclear Mechano-Oncology; U. Miami 3D Bioprinting Facility) maps to active Chinese pharma R&D / CDMO opportunities. Companion to the existing celvivo-clinoreactor-thewell-bioscience-xeno-free item.

china-cgt-2026-july-developments: monitor gene-editing trial death fallout + Merck–Bio-Techne / CARsgen satri-cel context for Chinese pharma / CDMO positioning

Owner: me
Source: web-search — Straits Times 2026-07-24 (score 0.313; patient death in China gene-editing trial draws fire); LiveScience 2026-07-24 (score 0.145; 6-year-old girl, investigation into gene-therapy regulations); SCMP 2026-07-29 (score 0.203; "Fear of policy backlash" — same-day coverage with this Tavily pull); Roots Analysis 2026-07-24 (score 0.669; Merck–Bio-Techne $11.3B acquisition June 2026 + CARsgen satri-cel CAR-T approval for stomach cancer June 2026); BioSpace 2026-07-27 (score 0.535; Summit/Merck China-first regulatory navigation)
Due: unscheduled
Status: open
Notes: Material new development in the China regulatory lane — sits on top of the existing china-cde-cell-gene-therapy-rules-2026 and china-order-no-818-clinical-translation items, not replacing them. Two positive signals (Merck–Bio-Techne acquisition; CARsgen satri-cel solid-tumor CAR-T approval) show the China CGT manufacturing environment is consolidating around advanced therapeutics. One negative signal (gene-editing trial death + published regulatory backlash) could foreshadow stricter CDE / NMPA / hospital-level oversight and tighter qualification criteria for "qualified hospitals" under Order No. 818. Together these affect: (a) qualification timelines for the CellShot-TriArm and ClinoReactor-class deals Robin has in flight, (b) which "qualified hospitals" remain eligible to host first-in-human studies, (c) whether CelVivo / 3Brain / Cellink vendor positioning for Chinese pharma R&D / CDMO accounts needs to change tone (e.g. emphasize safety documentation, IRB-grade workflows). Pull NMPA / hospital-IRB statements on the gene-editing trial case before next Chinese customer conversation.

3brain-coreplate-2026-conference-positioning: verify current CorePlate campaign and retrieve application material on next 3Brain check

Owner: me
Source: web-search — 3Brain official website plus 3Brain organization material captured through LinkedIn in Tavily pull 7 (2026-07-30); the dated result is 2026-07-25 and names ISSCR 2026 booth 412, while the company page also names ELRIG Drug Discovery booth 4. Tavily pull 11 (2026-08-03) adds a 3Brain LinkedIn post dated 2026-07-29 ("3Brain contributes to Utrecht Summer School course on Human Brain Models", score 0.808) — the first Tavily pull where the 3Brain answer text is not mis-attribution — and the 3Brain AG company LinkedIn page (score 0.839)
Due: unscheduled
Status: open
Notes: First credible direct 3Brain evidence after five Tavily pulls dominated by an unrelated EEG-paper mis-attribution. Vendor material positions CorePlate-enabled HD-MEA for high-resolution, scalable functional readouts from iPSC neuronal/cardiac models, brain organoids, assembloids, and 3D spheroids. Pull 11 extends the vendor-channel strand to the academic / training segment (Utrecht Summer School "Human Brain Models" course) on top of the ISSCR / ELRIG conference-booth strand from pull 7. Confirm which conference posts are current, obtain the named posters / application notes / Utrecht course module, and map them to Chinese neural-organoid and pharma-screening prospects. This pull does not establish CorePlate 1W/6W load force or Sample Holder Set details.

celvivo-clinostar-2-nams-demo-2026: verify product naming and campaign provenance on next CelVivo check

Owner: me
Source: web-search — Instagram snippets surfaced in Tavily pull 7 (2026-07-30): ClinoStar webinar copy (DbaUZjIjMgK), NexUs Locus on-site demo copy dated 2026-07-24 (DbKYC4NBtrN), and ClinoStar 2 NAMs positioning (DbSl7nkoFjK). Tavily pull 11 (2026-08-03) adds an independent confirmation from an Indian distributor event page (labindia-analytical.com News & Events, score 0.696) that CelVivo is exhibiting at Thailand Lab 2026 (Bangkok, 2026-09-02 → 2026-09-04) and that ClinoStar 2 is current product naming with oxygen regulation as a distinguishing feature
Due: unscheduled
Status: open
Notes: Watchlist lead, not a confirmed launch or customer win. Verify that the posts come from CelVivo or an authorized distributor, whether ClinoStar 2 is current official product naming, and whether the NexUs Locus live demo produced reusable data or contacts. Pull 11's labindia-analytical.com result is the first non-Instagram, named-event confirmation of ClinoStar 2 + Thailand Lab 2026; treat it as independent corroboration, not vendor-direct. The result set does not support Tavily's “installed base” language; one malformed duplicate URL was discarded.

cellink-volumetric-lumen-x-release: verify CELLINK × Volumetric new Lumen X release on next Cellink check

Owner: me
Source: web-search — Tavily pull 11 (2026-08-03) top hit on Cellink BIO X bioprinter 2026: 3DPrint.com 2026-07-28 (score 0.819) "CELLINK and Volumetric Release New Lumen X for Lumen X Bioprinting". Tavily answer text corroborates and adds BioMET '26 Vellore India (2026-08-05 → 2026-08-07) showcase detail. Companion evidence: Cellink LinkedIn 2026-07-29 (score 0.762) BioMET '26 exhibiting post; CELLINK Facebook 2026-07-28 (score 0.632) second-conference post
Due: unscheduled
Status: open
Notes: First credible direct Cellink product / partnership release evidence on the Robin portfolio after 10 prior Tavily pulls dominated by mis-attribution or BIO X Gen 3 / BIO X6 customer evidence (see existing cellink-bio-x-gen3-customer-evidence). Lumen X is in Robin's portfolio table ("Cellink — BIO X / BIONOVA X / Lumen X"). Verify with Cellink: (a) what is the relationship between CELLINK and Volumetric — co-marketing, OEM, distribution, or full acquisition; (b) is "New Lumen X" a distinct SKU from the original Lumen X (volumetric DLP) or a refresh; (c) does BioMET '26 Vellore presence map to any active Chinese pharma R&D / CDMO / biotech opportunities (likely India-channel rather than China-channel — adjacent to Robin's region); (d) does the existing cellink-bio-x-gen3-customer-evidence commitment's BIO X6 at U. Miami installation narrative change in light of this release.

itx-24h-host-build-2026-q3: finish assembly + Ubuntu + Hermes install on Robin's 24h host (paused since hardware is 10/11 arrived)

Owner: me
Source: git-repo — 03-Resources/ITX-24h-Host/ITX_24h_Host_v18_Config_2026-07-31.md (Obsidian vault, untracked as of fetch 2026-07-31T18:08:12Z)
Due: unscheduled (waiting for the last #8 / #9 cable parts on hand; once on hand, finish the assembly + software stack)
Status: open
Notes: Personal-infra work item (workflow-tooling priority LOW), not vendor-anchored — logged here because it is source-anchored to Robin's actual vault work per the brief's commitments.md rule ("only real Robin commitments"). Plan: mATX + i5-12400 + DDR4-2666 32G + 板载 Realtek 1Gb + Intel PRO/1000 GT (¥2,985.82, 10/11 parts on hand). Two 网卡 VLAN: 192.168.31.100 → 主力机 Win 11 SSH, 10.10.10.254 → 主力 NAS RAGFlow. Post-assembly steps: Ubuntu Server 22.04 LTS install, partition / (GM7 512G) + /data (mSATA 512G), Docker, dual-NIC 静态 IP, 主力机 SSH key 免密, NAS RAGFlow API 接入, 安装 Hermes Agent, 24h 跑功耗 soak test. The host has no vendor-product overlap; not promoted to /themes.md row because that index is reserved for recurring workflow signals.

liu-2026-hd-mea-roadmap-implication: verify with 3Brain whether the Liu 2026 shape-conformal framework is on their product roadmap

Owner: me
Source: literature flywheel-sync 2026-08-08 — Liu N et al. (2026) Nature Biomedical Engineering, DOI 10.1038/s41551-026-01620-y, Wiki.js Id 1692, NocoDB row 1 in new table Robin_Picked_Papers (created 2026-08-08, table_id mbjo0wb56qv1qly), SeaFile PDF https://fb.biokingdom.top/f/6da50240729e41bdb369/?dl=1. Deep-read synthesis at /sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md
Due: unscheduled
Status: open
Notes: Highest product-relevance cluster of today's flywheel-sync: HD-MEA rating 5 (3000-8000 channels vs current 3Brain Accura-3D 4096; >90% surface coverage vs 5-15% bottom-only), 3D bioprinting microlattice rating 5 (Cellink BIONOVA X / Lumen X cannot directly print at this resolution today but the field direction is clear), patient-derived organoid drug screening rating 5 (first long-term high-throughput electrophysiology drug screening platform — weeks-long stable recording + epilepsy + AD disease modeling). Robin should sell 3Brain's current 4096-electrode Accura-3D as the existing best-in-class AND track whether 3Brain has a flexible-electronics / shape-conformal framework on their roadmap. Companion question on /open-questions.md: liu-2026-rogers-lab-vs-3brain-relationship (is there any partnership / licensing / competitive pressure between Rogers Lab and 3Brain?). Companion commitment to verify with Cellink: liu-2026-cellink-microlattice-positioning (whether BIONOVA X or Lumen X can fabricate flexible-electronics-compatible microlattices).

miao-2025-celvivo-clinostar-positioning: fold Miao 2025 vHLPO co-differentiation story into CelVivo ClinoStar sales narrative

Owner: me
Source: literature flywheel-sync 2026-08-08 — Miao Y et al. (2025) Cell v2, DOI 10.1016/j.cell.2025.05.041, PMID 40592324, Wiki.js Id 1681, NocoDB row 93, SeaFile PDF https://fb.biokingdom.top/f/24704d54a95941449e2e/?dl=1. Deep-read synthesis at /sources/literature-miao-2025-cell-vascularization-v2-deepread.md
Due: unscheduled
Status: open
Notes: Strongest CelVivo ClinoStar product relevance rating (5) in any of the 3 new flywheel-sync papers — the vHLPO single 3D EB co-induction (mesoderm+endoderm) protocol depends on 3D EB self-organization in low-shear rotating culture, which is exactly what ClinoStar provides. vHLPO 7% ECs vs traditional HLPO 0% is a clinically-meaningful differentiator that no competing 2D / static culture can match. Sales ammunition: "your lung organoid model is missing 100% of vasculature — ClinoStar co-differentiation gives you 7% ECs vs 0%". Cross-vendor co-marketing: CelVivo ClinoStar (culture) + Cellink BIO X (decellularized lung scaffold) + 3Brain HD-MEA (functional readout on the neural mesenchyme). Robin should fold this into the CelVivo industrial-customers program (existing CelVivo_中国工业客户开发研究报告 v1 + v2 in vault) and pitch to pediatric-hospital pharma R&D accounts (FOXF1 ACDMPV rare disease).

liang-2026-celvivo-clinostar-positioning: fold Liang 2026 长程成熟 + 体外纤维化模型 story into CelVivo ClinoStar / ClinoReactor sales narrative

Owner: me
Source: git-repo-1 2026-08-12 (vault commit cluster e542c977 → 8699a154 → aacba7aa → 297f106d) — Liang Y, Ye Y, Xie H, Lui VCH, Chen Y, Tam PKH. (2026) Scientific Reports DOI 10.1038/s41598-026-42990-2, PMID 41857098; Wiki.js Id 1716, NocoDB Id 770; SeaFile PDF https://fb.biokingdom.top/f/9d53cfaaa88a45b49b72/?dl=1 + 7 真图 (Fig1-7); vault path 04-Literature/Deep-Reads/Liver/2026-08-12_Liang_2026_SciRep_liver_organoid_fibrosis_platform.md (170 lines; 4-commit LDR cycle)
Due: unscheduled
Status: open
Notes: Parallel CelVivo ClinoStar rating 4 + ClinoReactor rating 4 to the existing miao-2025-celvivo-clinostar-positioning but for liver organoid (long-term maturation + fibrosis modeling) rather than lung organoid (vascularization). Single tissue 3-轨道 (Hep-Orgs + Cho-Orgs + HSC) → DAPT (Notch 抑制) + Dexamethasone for P1-P10 长程稳定成熟 (single DAPT only sustains P5; DAPT+Dex 协同才实现 P10) → TGFβ 5-7 day activation of qHSC → aHSC (Acta2/Col1a1 上调) → aHSC 共培养诱导 Hep-Orgs EMT (Snail/Twist/Vimentin ↑; ALB/CK8 ↓; Lgr5/EpCAM ↓; Ki67 ↓) = 体外肝纤维化模型. Sales ammunition: "你的肝类器官只能短期培养? DAPT+Dex P1-P10 稳定成熟 + 单组织 3 轨道 + 14 天纤维化模型 — ClinoStar + ClinoReactor 一站搞定"; paired with "你的抗纤维化药筛需要 14+ 天 3D 多细胞模型 — ClinoReactor 6 通道一次测 6 药". Cross-vendor co-marketing: CelVivo ClinoStar (P1-P10 旋转扩增) + CelVivo ClinoReactor (3 轨道分通道灌流 + TGFβ 时间程序精确切换) + 3Brain HD-MEA (肝-神经互作延伸, 胆碱能投射场景). Customer entry: (a) 药企临床前 — 抗纤维化药筛 14+ 天 3D 多细胞模型 (traditional 2D 或单细胞模型失真); (b) 临床肝活检中心 — 1-2 mg 组织 → 3 轨道 → 3 周内药敏测试 (患者来源 anti-fibrosis drug sensitivity); (c) 学术 PI — 2D 静态分化效率低 → 3D 旋转培养效率提升 2-3 倍. Robin should fold this into the CelVivo industrial-customers program (existing CelVivo_中国工业客户开发研究报告 v1 + v2 in vault) alongside the Miao 2025 vHLPO entry — these two papers together give a liver + lung CelVivo ClinoStar sales narrative with no 3D-bioprinting vendor dependency. The paper's related: field already names [[MOC-类器官与3D培养]] (the 2026-08-10 first MOC) — confirms the MOC pattern is in active use on real deep-reads on the day of publication.

robin-picked-papers-nocodb-table: capture the structural change — new NocoDB table for Robin-handpicked papers

Owner: me
Source: literature flywheel-sync 2026-08-08 — Liu 2026 is the first entry in the new NocoDB table Robin_Picked_Papers (table_id mbjo0wb56qv1qly), created 2026-08-08 per Robin instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage. The table is separate from the existing Organoid_Literature table.
Due: unscheduled
Status: open
Notes: The new table has 9 fields: Title, DOI, Journal, Year, Authors, Source, wiki_url, pdf_url, deep_read_summary. Future handpicked papers should land in this table rather than in Organoid_Literature (which is PubMed-triage-driven). Verify with Robin: (a) what is the workflow for capturing a handpicked paper — manual PDF drop to /home/ldw/.hermes/cache/documents/ and then trigger the LDR pipeline; (b) should the LDR pipeline auto-route by signal (PubMed triage vs handpicked), or does Robin always provide the routing signal.

dong-huiqun-ji-nan-chengquan-link: confirm whether 董慧群 is a 济南成全生物科技技术同事, and route 卸慧群档案 accordingly

Owner: me
Source: git-repo 2026-08-08 — 02-Clients/Agents/_known_associations.md (commit 4b237a82, Hermes Agent 2026-08-07 hook 4) maps 济南成全生物科技有限公司 (曹沛起) as the only CelVivo ClinoStar-listed agent in the 259-dealer China map (华北 + 山东跨区重复登记). 02-Clients/Agents/董慧群.md (2026-07-28 commit 21491578) lists 董慧群 as CelVivo 产品技术同事 with agency: 待补.
Due: unscheduled
Status: open
Notes: The 2026-08-07 hook 4 partial-resolution gave a likely candidate (济南成全生物科技曹沛起 company) but the precise link to 董慧群 (and whether she is 济南成全的技术同事, or another dealer) is still unverified. Action: Robin to verify with 董慧群 directly via WeChat / 微信 (current open-question /open-questions.md agent-dong-huiqun-celvivo). Once confirmed: update 02-Clients/Agents/董慧群.md frontmatter agency field, and update /sources/agents.md "代理商品牌" column from "待补" to "济南成全生物科技 (曹沛起)". Until this is done, 董慧群's role in the 济南成全 book of business is unconfirmed.

distributors-2026-08-07-refresh: 落地 2026-08-07 全国经销商地图到 wiki + 跨工具

Owner: me
Source: git-repo 2026-08-08 — Obsidian vault 02-Clients/Agents/全国经销商地图-2026-0807.md + 7 区域分文件 (8-07 baseline, 259 dealers across 7 regions, net change -2 from 2026-07-24 baseline). Vault raw survives 2026-08-08 fetch as untracked files (commit 4b237a82 Lin Yongli "4 个经销商管理 Hook 升级").
Due: unscheduled
Status: open
Notes: 8-07 baseline differs from 7-24 baseline in: (a) total 261 → 259 (华北 74 → 72); (b) 济南成全生物科技有限公司 (曹沛起) cross-region registration (华北 + 山东); (c) new _known_associations.md index maps CelVivo → 济南成全 / FemtoBiomed → 9X Bio → TriArm / 3Brain + Cellink → 0. Cross-reference: /sources/distributors-china-2026.md has been updated to the 8-07 baseline + new associations table; /sources/agents.md still needs the 董慧群 → 济南成全 link; /commitments.md has follow-up for 成都百乐 vs 成都立德赛 decision (open-question chengdu-baile-vs-lidesai-for-ou-xianhong). End-customer coverage for 3Brain / Cellink / FemtoBiomed still 0 in the 259 baseline — see open-question distributors-3brain-cellink-zero-coverage.

guo-2026-organoid-irb-checklist-rollout: commit IRB application checklist template + add Guo 2026 deep-read synthesis page + fold into CelVivo industrial-customers program

Owner: me
Source: git-repo-1 2026-08-17 — vault commit cluster 2e6f5989 → 00f824f2 → a4fa5a32 (Guo Z & Zhang N 2026 Front Cell Dev Biol organoid IRB / ethics systematic review, Wiki.js ID 1724, NocoDB Id 3298, DOI 10.3389/fcell.2026.1721946) + new untracked templates/类器官IRB申请清单.md v1.0 (180 lines, Robin 8-16 实战沉淀, derived from the Guo 2026 paper)
Due: unscheduled
Status: open
Notes: First customer-facing template produced from a single deep-read in Robin's vault — the IRB application checklist is the canonical "Robin 培训客户 IRB 申请" core material for class A tertiary hospitals running organoid IRB submissions. The 7 mandatory points + 5 customer Q&A + China vs International flow table + 10 attachments + 7 citations map directly to the CelVivo ClinoStar clinical-translation sales narrative (Guo 2026 lists CelVivo ClinoStar ⭐⭐⭐⭐ for IRB compliance ammunition). Three follow-ups needed: (a) commit templates/类器官IRB申请清单.md to main (currently untracked); (b) add a wiki-side deep-read synthesis page at /sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md mirroring the pattern at /sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md; (c) fold the IRB checklist into the existing 05-Documents/Products/Celvivo/Industrial-Customers/ CelVivo commercial docs subtree (or, if the templates/ folder convention holds, fold it into the new templates/ vault subtree instead — see Robin decision). Companion commitment to fold into Chinese customer IRB conversations: the checklist covers China《人类遗传资源管理条例》+ 《涉及人的生命科学和医学研究伦理审查办法》2023 — directly applicable to the next Class A tertiary hospital Robin visits for CelVivo or 3Brain training.

celvivo-app-note-2026-clinostar-vs-orbital-shaker-positioning: fold the head-to-head shear-stress comparison into ClinoStar sales narrative + CelVivo赋能培训

Owner: me
Source: git-repo-1 2026-08-24 — vault commit fb017e4f (CelVivo Application Note 2026 shear stress ClinoStar vs orbital shaker, Wiki.js 1747, sourced from RAGFlow CelVivo KB 1555e5b2..., Robin 8-24 上传; vault path obsidian-vault/04-Literature/Deep-Reads/CelVivo_Shear_Stress_AppNote_2026.md, 10,145 bytes, single-shot LDR entry)
Due: unscheduled
Status: open
Notes: Canonical ClinoStar vs-orbital-shaker competitive-killer document — the App Note establishes head-to-head comparison of ClinoStar® vs orbital shaker for 3D 类器官/球体培养 (HepG2/C3A 15-day + embedded Caco-2 肠 + brain organoid) with 3 bio-replicates per condition. Core findings: (a) low shear stress ClinoStar preserves cytoskeletal integrity — phalloidin/DAPI 染色 shows ClinoStar F-actin 排列规则 + 形态紧凑 + 细胞间内聚性强 vs orbital shaker F-actin 散布 + 形态松散 + 内聚性下降 (4x + 20x dual magnification); (b) 15-day standardized workflow — same source cells + same pre-conditioning + same end-point assays; (c) multi-model transferability — embedded Caco-2 + brain organoid both show ClinoStar advantage → vendor claim "low shear stress sensitive cell class (肝/肠/脑来源)" validated across 3 model systems. Highest commercial-relevance paper of the 2026-08-23 LDR cluster — Robin's first vendor App Note deep-read (vs prior primary research + review only). Sales ammunition: "你的 orbital shaker 培养球体 F-actin 散布 + 内聚性下降 — ClinoStar 旋转培养保持细胞骨架完整 + 形态紧凑 — 15 天数据 + 3 bio-replicate 标准流程 + 3 类细胞模型 (HepG2 + Caco-2 + brain organoid)". Companion to existing celvivo-clinoreactor-thewell-bioscience-xeno-free commitment. Follow-ups: (a) fold the App Note into 06-Sales/Content/Training-Materials/ (the existing CelVivo赋能培训 v1-v9 cluster could absorb the head-to-head comparison data as a new PPT module); (b) add a wiki-side deep-read synthesis page at /sources/literature-celvivo-shear-stress-appnote-2026-deepread.md; (c) confirm with CelVivo whether this App Note is officially sanctioned for Robin's China customer use.

aiello-2025-rc-cfd-clinostar-positioning: fold the < 20 mPa quantitative CFD number into CelVivo ClinoStar sales narrative

Owner: me
Source: git-repo-1 2026-08-24 — vault commit f2118a62 (Aiello & Bagni 2025 biorxiv preprint Rotating Chamber brain organoid CFD, Wiki.js 1746, the EMBO Reports submission version Aiello_Bagni_EMBO R_050325, Robin 8-24 从 CelVivo KB 找到的 PDF; vault path obsidian-vault/04-Literature/Deep-Reads/Aiello_Bagni_2025_biorxiv_Brain_Organoid_Fluid.md, 11,731 bytes, single-shot LDR entry)
Due: unscheduled
Status: open
Notes: First CFD-quantified Rotating Chamber (RC) low-shear-stress study in Robin's deep-read set — the paper quantifies what prior ClinoStar marketing material only described qualitatively. Core finding: COMSOL Multiphysics 6.2 CFD simulation shows cavity shear stress < 20 mPa (extremely low vs. standard stirred/shaken systems) — the first quantitative number for RC shear-stress field. Multi-density validation: relative density 1010/1020/1030 vs medium 1000 confirms shear-stress uniformity across density range + 0-300 objects all experience stable low shear. Morphological CV < 15% across batches + cell lines vs static culture CV > 30%. Cortical cell type recapitulation (SOX2/Nestin/PAX6 + DCX + TBR1/SATB2/MAP2 multi-marker IHC) + scRNA-seq OXPHOS metabolic profiling. Vendor-anchor mapping: Aiello paper is CelVivo ClinoStar-adjacent (uses RC system which is the ClinoStar simplified geometry) + 3Brain HD-MEA-adjacent (cortical organoid electrophysiology read-out). Sales ammunition: "你的类器官培养系统剪切力是多少? 静态培养 = 不均匀; orbital shaker = 不均匀; ClinoStar 旋转腔 = < 20 mPa (CFD 量化) + 跨密度一致 + 跨批次形态变异 < 15%". The < 20 mPa number is direct ammunition for the existing ClinoStar ⭐⭐⭐⭐ vendor-positioning pitch — no prior paper in Robin's deep-read set provides the quantitative CFD number. Follow-ups: (a) add a wiki-side deep-read synthesis page at /sources/literature-aiello-2025-biorxiv-brain-organoid-fluid-deepread.md; (b) fold the < 20 mPa number into the ClinoStar industrial-customers program alongside the Miao 2025 vHLPO + Liang 2026 liver organoid entries.

kim-2025-egain-3d-mea-vs-3brain-positioning: track the next-gen HD-MEA field consolidation (Liu 2026 Rogers Lab + Kim 2025 EGaIn + 3Brain Accura-3D)

Owner: me
Source: git-repo-1 2026-08-24 — vault commit 5f02489a (Kim E, Jeong E, Hong YM et al. 2025 Nat Commun liquid-metal 3D MEA, DOI 10.1038/s41467-024-55752-3, Wiki.js 1744; vault path obsidian-vault/04-Literature/Deep-Reads/Kim_2025_NatCommun_Liquid_Metal_3D_MEA.md, 13,567 bytes, single-shot LDR entry)
Due: unscheduled
Status: open
Notes: 3 distinct next-gen HD-MEA approaches now in Robin's deep-read set: (a) Liu 2026 Nat Biomed Eng (Rogers Lab flexible-electronics shape-conformal framework, 3000-8000 channels per organoid, >90% surface coverage) — see existing liu-2026-hd-mea-roadmap-implication commitment; (b) Kim 2025 Nat Commun (EGaIn liquid-metal 3D pillar MEA, 25-310 μm pillar height, 14 μm diameter, parylene-C selective encapsulation, Ni magnetic layer for shape reconfiguration); (c) 3Brain Accura-3D (rigid CMOS, 4096 electrodes, planar). The Kim paper is 3Brain HD-MEA competitor / adjacent paper — Kim's EGaIn 3D MEA is a next-generation flexible 3D MEA approach that is adjacent to but not directly competing with 3Brain's rigid Accura-3D chip. Vendor-anchor mapping: Kim paper pairs with Liu 2026 to anchor the next-gen HD-MEA field consolidation narrative that Robin's existing liu-2026-hd-mea-roadmap-implication commitment tracks. Robin should pitch 3Brain's current 4096-electrode Accura-3D as the existing best-in-class AND track whether 3Brain has a flexible-electronics / EGaIn-3D-pillar framework on their roadmap. Follow-ups: (a) add a wiki-side deep-read synthesis page at /sources/literature-kim-2025-nat-commun-liquid-metal-3d-mea-deepread.md; (b) update the liu-2026-hd-mea-roadmap-implication commitment's Notes to reference Kim 2025 as the second corroborating evidence point (Liu + Kim = 2 distinct next-gen approaches); (c) verify with 3Brain whether the EGaIn / flexible-electronics / shape-conformal directions are on their 2026-2027 product roadmap.

ajongbolo-2025-brain-organoid-review-cluster: pair with Organoids 2026 review to anchor brain-organoid review lane

Owner: me
Source: git-repo-1 2026-08-24 — vault commit ad4abcde (Ajongbolo AO, Langhans SA 2025 Cells brain organoid + assembloid review, DOI 10.3390/cells14110842, Wiki.js 1743; vault path obsidian-vault/04-Literature/Deep-Reads/Ajongbolo_2025_Cells_Brain_Organoids_Review.md, 11,367 bytes, single-shot LDR entry)
Due: unscheduled
Status: open
Notes: Canonical brain organoid + assembloid review for Robin's deep-read set — the paper establishes a 3-tier taxonomy (whole-brain → region-specific → complex systems) + 4-class characterization methodology (morphological + biochemical + functional + omics) + disease-modeling boundaries (neurodevelopmental / neurodegenerative / brain-tumor) + drug-discovery HTS pipeline. First comprehensive brain-organoid review in Robin's deep-read set since the 2026-07-29 Organoids 2026 review (10.1186_s40164-026-00743-x, vault path 04-Literature/Deep-Reads/Organoid/2026-07-29_Organoids_disease_modeling_treatment_2026_review.md). Pairs with that review to anchor the brain-organoid review-paper lane. Vendor-anchor mapping: CelVivo ClinoStar-adjacent (long-term stable brain organoid culture) + 3Brain HD-MEA-adjacent (functional electrophysiology read-out via MEA in the 4-class characterization methodology). Follow-ups: (a) add a wiki-side deep-read synthesis page at /sources/literature-ajongbolo-2025-cells-brain-organoids-review-deepread.md; (b) cross-link the Ajongbolo synthesis page with the existing Organoids 2026 review entry on /themes/05-robin-research.md review-paper cluster; (c) consider promoting the brain-organoid review lane to a /themes.md row if a 2026-08-25 fetch surfaces another brain-organoid paper.

tian-2025-epicardium-mtor-cardiac-expansion: track cardiac epicardium lane for potential CDMO/regenerative-medicine opportunities

Owner: me
Source: git-repo-1 2026-08-24 — vault commit 40b357b8 (Tian Y, Lucena-Cacace A, Tani K et al. 2025 Nat Commun hiPSC epicardium mTOR maturation, DOI 10.1038/s41467-025-60934-8, Wiki.js 1745; vault path obsidian-vault/04-Literature/Deep-Reads/Tian_2025_NatCommun_Epicardium_mTOR.md, 15,578 bytes, single-shot LDR entry)
Due: unscheduled
Status: open
Notes: First cardiac-epicardium paper in Robin's deep-read set — Tian paper establishes Torin1 (dual mTORC1/2 inhibitor, 200 nM) drives hiPSC epicardium maturation with mature markers (TJP1/WT1/TBX18/ALDH1A2/CDH18) up + EMT markers down + proliferation markers down + fatty-acid metabolism maturation; 379 DEGs; adult-like profile vs GSE84085; YBX3 + MAFF identified as Torin1-specific TFs; paracrine TNNI3 upregulation in hiPSC ventricular cardiomyocyte EBs co-cultured for 10 days (epicardium-to-cardiomyocyte maturation cross-talk). Application domain: cardiac organoid regeneration — fits the broad cardiac application-domain bucket that Robin's wiki scope covers. No vendor callouts in the deep-read (no CelVivo / 3Brain / Cellink / FemtoBiomed product rating) but the paracrine cross-talk finding is a candidate for cross-vendor positioning if Robin pitches cardiac-regeneration programs to pharma R&D or CDMO accounts. The 15,578-byte size is the largest of the 5 new LDR files — reflects Robin's deep-dive on the mTOR pathway mechanism. Follow-ups: (a) add a wiki-side deep-read synthesis page at /sources/literature-tian-2025-nat-commun-epicardium-mtor-deepread.md; (b) verify whether any active Chinese pharma R&D / CDMO / regenerative-medicine account maps to the cardiac-epicardium lane (the active CRM profile set is mostly CelVivo / 3Brain neural-organoid focused — no cardiac-epicardium customer dossier surfaced yet); (c) consider whether Robin should fold cardiac into the existing /themes/01-organoid-equipment.md theme or open a new theme-cardiac-regeneration.md if cardiac papers recur.

tevonian-2026-vascularized-liver-mps-positioning: Tevonian 2026 Nat Commun vascularized liver MPS vendor-mapping + 中国药企 hepatic-IR 药筛 positioning

Owner: me
Source: git-repo-1 2026-08-25 — vault commit 089177a7 (Tevonian et al. 2026 Nat Commun vascularized liver microphysiological system, PMID 41634021, DOI 10.1038/s41467-025-68031-6; vault path obsidian-vault/04-Literature/Deep-Reads/Vascularized-Organoids/Tevonian_2026_Nat_Commun_Vascularized_Liver_MPS.md, first file in new Vascularized-Organoids/ subfolder)
Due: unscheduled
Status: open
Notes: First vascularized liver MPS paper in Robin's deep-read set; 5-vendor product mapping retrofit applied via the 9aa2af4c post-publish retrofit commit (CelVivo ClinoStar / ClinoReactor + Cellink BIO X + Mimetas OrganoPlate + 3Brain HD-MEA + FemtoBiomed CellShot). Mimetas OrganoPlate is the canonical microphysiological system for the multi-channel vascularized liver architecture (PDMS + fibrin + primary hepatocytes + HUVEC) + CelVivo ClinoReactor for upstream hepatocyte maturation (Hep-Orgs source) + Cellink BIO X for the decellularized liver scaffold matrix. Application domain: vascularized liver MASLD/NASH 体外建模 + 个性化药筛 + 血管化类器官平台. Companion to the existing Liang 2026 liver organoid entry (ClinoStar ⭐⭐⭐⭐ for P1-P10 long-term maturation + ClinoReactor ⭐⭐⭐⭐ for 3-track HEP/CHO/HSC perfusion) — Tevonian 血管化 dimension extends the existing Liver/ subfolder's fibrotic disease modeling story. Follow-ups: (a) add a wiki-side deep-read synthesis page at /sources/literature-tevonian-2026-nat-commun-vascularized-liver-mps-deepread.md; (b) cross-link Tevonian with Shen 2026 in the new Vascularized-Organoids/ subfolder to anchor a vascularized-organoid review-paper cluster; (c) verify whether the active MASLD/NASH hepatic-IR account dossier (if any in the CRM) maps to Mimetas OrganoPlate CelVivo ClinoReactor + Cellink BIO X as a triple-vendor solution.

yang-2026-cardiac-organoid-review-positioning: Yang 2026 Stem Cell Res Ther cardiac organoid review vendor-mapping + 心脏药物毒性测试 positioning

Owner: me
Source: git-repo-1 2026-08-25 — vault commit 583859a8 (Yang L et al. 2026 Stem Cell Res Ther cardiac organoid review, PMID 41963991, DOI 10.1186/s13287-026-04996-5; vault path obsidian-vault/04-Literature/Deep-Reads/Cardiac-Organoids/Yang_2026_Stem_Cell_Res_Ther_Cardiac_Organoid_Review.md, first file in new Cardiac-Organoids/ subfolder)
Due: unscheduled
Status: open
Notes: First comprehensive cardiac organoid review in Robin's deep-read set; 5-vendor product mapping retrofit applied via the 9aa2af4c post-publish retrofit commit (same 5-vendor mapping as Tevonian). Companion to Tian 2025 Nat Commun (the cardiac epicardium mTOR paper from the 2026-08-23 burst) which established the actual mechanistic depth — Yang 2026 is the canonical review that contextualizes Tian alongside the prior cardiac organoid literature (hPSC cardiac organoid generation methods, maturation protocols, disease modeling applications, regenerative medicine routes). Covers FGF/PI3K/Wnt/BMP/Activin/RA 五大信号通路 + 三种 3D 培养策略. Application domain: cardiac organoid — Robin expands from the prior 2-paper Cardiac/ subfolder to a dedicated Cardiac-Organoids/ subfolder; first time Robin has opened a new subfolder explicitly for an application-domain cluster. Robin 业务对接: 心脏药物毒性测试 + hiPSC 衍生心脏类器官服务 + 心血管疾病建模. Follow-ups: (a) add a wiki-side deep-read synthesis page at /sources/literature-yang-2026-stem-cell-res-ther-cardiac-organoid-review-deepread.md; (b) pair Tian + Yang as a paired mechanistic + review cluster on /themes/05-robin-research.md; (c) verify whether any active Chinese pharma R&D cardiac-toxicology account maps to CelVivo + 3Brain as a paired vendor solution for hiPSC-derived cardiac organoid electrophysiology.

shen-2026-vascularized-organoid-chinese-review: Shen 2026 Chin Med J vascularized organoid systematic review for Chinese-hospital IRB positioning

Owner: me
Source: git-repo-1 2026-08-25 — vault commit 5907cdfc (Shen Y et al. Chin Med J 2026 vascularized organoids systematic review, PMID 42268296, DOI 10.1097/CM9.0000000000004136; vault path obsidian-vault/04-Literature/Deep-Reads/Vascularized-Organoids/Shen_2026_Chin_Med_J_Vascularized_Organoids_Review.md, Chinese-language peer-reviewed systematic review from 华西医院, second file in new Vascularized-Organoids/ subfolder)
Due: unscheduled
Status: open
Notes: Chinese-language peer-reviewed vascularized organoid systematic review — establishes credential Chinese-hospital-academic source for Robin's active Chinese pharma R&D / CDMO customer base. Structures vascularized organoid 4 大策略 (共培养 + 转录因子诱导 + 微流控 + 生物材料支架) + 12 维对比 + 三大未来方向. Vendor anchor mapping: TBD — not retrofitted by 9aa2af4c (only Tevonian + Yang got the 5-vendor retrofit). Application domain: vascularized organoid — adds a 2-paper cluster to the new Vascularized-Organoids/ subfolder. The Shen 2026 review is the review-paper anchor and Tevonian 2026 is the research-paper anchor. Robin 业务对接: 血管化类器官服务 + 多层血管网络平台 + 个性化精准医疗. Follow-ups: (a) add a wiki-side deep-read synthesis page at /sources/literature-shen-2026-cmj-vascularized-organoids-review-deepread.md; (b) cross-link with Tevonian 2026 to anchor a vascularized-organoid review-paper cluster; (c) verify whether the Chinese-language source yields any CelVivo-specific IRB or vascularization positioning material for Chinese-hospital customer conversations.

zhai-2026-skin-organoid-pemphigus-positioning: Zhai 2026 Sci Adv 3D skin pemphigus autoimmune dermatology positioning

Owner: me
Source: git-repo-1 2026-08-25 — vault commit 9d4767c7 (Zhai T et al. Sci Adv 2026 3D skin pemphigus, PMID 41512055, DOI 10.1126/sciadv.adz5003; vault path obsidian-vault/04-Literature/Deep-Reads/Skin-Organoids/Zhai_2026_Sci_Adv_3D_Skin_Pemphigus.md, first file in new Skin-Organoids/ subfolder, net-new application domain — autoimmune dermatology + 3D skin)
Due: unscheduled
Status: open
Notes: First 3D-skin organoid disease-modeling paper in Robin's deep-read set; net-new application domain (autoimmune dermatology + 3D skin) that Robin's existing ~22 deep-read subfolders do not cover. Uses 3D 打印 + 自组织多层血管化皮肤模型 to model 天疱疮 (pemphigus) autoimmune disease + EGFR 靶向治疗 + ML 辅助药筛. Vendor anchor mapping: TBD — Zhai paper does NOT have the 9aa2af4c retrofit 5-vendor mapping (only Tevonian + Yang got the retrofit). Skin organoid is a candidate workflow for CelVivo ClinoReactor (long-term 3D skin culture — similar to the existing liver, brain, lung, retinal organoid applications) but the Sci Adv paper's specific ClinoReactor / ClinoStar callouts are not in the manifest entry. Application domain: 3D skin organoid + autoimmune dermatology (pemphigus) — distinct from the existing Cancer / Brain / Liver / Vascularized-Organoids / Cardiac-Organoids / Kidney / Retinal / Brain-Tumor application-domain subfolders. Robin 业务对接: 皮肤自身免疫病药筛 + 3D 打印客户 + 精准医疗应用. Follow-ups: (a) add a wiki-side deep-read synthesis page at /sources/literature-zhai-2026-sciadv-3d-skin-pemphigus-deepread.md; (b) verify whether the Skin-Organoids subfolder accumulates ≥3 entries to confirm a recurring application-domain pattern; (c) check whether the Zhai paper yields Chinese cosmetic / dermatology pharma R&D positioning material that the active CRM portfolio could absorb.

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