428 lines
102 KiB
Markdown
428 lines
102 KiB
Markdown
---
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type: "Reference"
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title: "Theme 5 · Robin's personal research (vendor deep reads + sales ammunition + CRM)"
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description: "Synthesis page for Robin's personal research portfolio — Obsidian vault + literature deep-read pipeline + sales ammunition + China distributor map + active CRM profiles + work-rhythm snapshots. Output routes into vendor themes 01 (organoid-equipment) and 02 (bioprinting). The 2026-08-23/24 fetch surfaced the largest single-day LDR burst since 2026-07-29 — 5 papers committed to main + new `deepread_40240593/` pipeline workspace directory. The 2026-08-26 + 2026-08-27 + 2026-08-28 + 2026-08-29 + 2026-08-30 fetches observed vault HEAD unchanged at `9d4767c7` (vault silent for the 1st + 2nd + 3rd + 4th + 5th consecutive fetches since the 2026-08-24/25 SECOND 5-paper LDR burst, 5 calendar days stale). The 2026-08-31 fetch observed vault HEAD bumped `9d4767c7` → `391e4713` — **THIRD consecutive single-day 5-paper LDR burst** (Stewart + Aiello + Nguyen + Miao + Yan, all CelVivo-anchored, all in the NEW `obsidian-vault/04-Literature/Deep-Reads/CelVivo/` capital-V subfolder — Robin's first parallel-naming deep-read subfolder convention), ending the 5-day vault silence; combined with the 2026-08-23/24 + 2026-08-24/25 clusters, **15 LDR files in 8 calendar days = the largest sustained 8-day research output** in Robin's vault activity log. The 2026-09-01 + 2026-09-02 + 2026-09-03 + 2026-09-04 + 2026-09-05 + 2026-09-06 + 2026-09-07 + 2026-09-08 + 2026-09-09 fetches observed vault HEAD unchanged at `391e4713` (vault silent for the 1st + 2nd + 3rd + 4th + 5th + 6th + 7th + 8th + 9th consecutive fetches since the 2026-08-31 THIRD consecutive 5-paper CelVivo LDR burst, **9 calendar days stale**). The 2026-09-11 fetch observed vault HEAD bumped `391e4713` → **`09bec367`** — **vault silence streak BROKEN after 11 calendar days** with **2 new vault commits**: `1fd63019` 2026-09-10 (Tomas 2026 HGSC carboplatin/PARPi spheroid+organoid, Western University, **0 vendor callouts**) + `09bec367` 2026-09-11 (Vijakumaran 2026 brain-organoid air-liquid interface oxygen engineering, **first v4 Flywheel auto-sink pipeline entry**); the pipeline has resumed after the 11-day pause. The 4 carry-forward untracked directories (Review + templates + celvivo_commercial + deepread_40240593) bump their carry-forward counts to **30/25/25/18 days** at the 2026-09-11T18:14Z fetch — the `Review/` + `templates/` + `celvivo_commercial/` entries remain **confirmed one-off** (carrying forward unchanged since the 2026-08-28 fetch) and continue as stale / not recurring carry-forward notes; the `deepread_40240593/` working-folder pipeline hypothesis continues to weaken (mtime unchanged across 17 consecutive silent fetches since the 2026-08-24/25 burst). The **2026-09-13T18:08Z fetch** is the **31st git-repo-1 fetch of the 2026-08-07 streak** + the **2nd consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`); **1 working-tree modification** was observed at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) — Robin actively editing the MOC index file but NOT yet committed; the 4 carry-forward untracked directories bump to **32/27/27/20 days** at the 2026-09-13T18:08Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 4 new automated wiki commits in the 48-hour window (`7cfb801` sources-sync 2026-09-12 twenty-ninth + `999a37d` daily update 2026-09-12 + `0447186` daily update 2026-09-13 + `5f33bd3` sources-sync 2026-09-13 thirtieth) bumped wiki HEAD `55d930f` → `5f33bd3`; the 8-dirty-file baseline (down from the prior 10-dirty-file baseline) shows the daily-update cycle cleared `index.md` + `quickstart.md` + `sources/git-repo.md` + `themes.md` while `sources/openwiki-version-drift.md` was newly re-touched; synthesis-layer impact is **none** because vault produced no new external evidence. The **2026-09-16T18:18Z fetch** is the **32nd git-repo-1 fetch of the 2026-08-07 streak** + the **5th consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`, **5 calendar days of vault silence**); the **1 working-tree modification** at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) **persists uncommitted for 3 calendar days** at the 2026-09-16T18:18Z fetch without further changes; the 4 carry-forward untracked directories bump to **35/30/30/23 days** at the 2026-09-16T18:18Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 6 new automated wiki commits in the 72-hour window (`667730f` daily update 2026-09-14 + `09f47d6` sources-sync 2026-09-14 thirty-first + `f38cebf` daily update 2026-09-15 + `f5465f9` sources-sync 2026-09-15 thirty-second + `73dae5e` daily update 2026-09-16 + `ac46732` sources-sync 2026-09-16 thirty-third) bumped wiki HEAD `5f33bd3` → `ac46732`; the 11-dirty-file baseline (up from the prior 8-dirty-file baseline) shows the 3 daily-update cycles re-touched `index.md` + `quickstart.md` + `themes.md` + the 3 sources-syncs re-touched the 4 source-sync files each cycle; synthesis-layer impact is **none** because vault produced no new external evidence. The **2026-09-17T18:22Z fetch** is the **33rd git-repo-1 fetch of the 2026-08-07 streak** + the **6th consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`, **6 calendar days of vault silence**); the **1 working-tree modification** at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) **persists uncommitted for 4 calendar days** at the 2026-09-17T18:22Z fetch without further changes; the 4 carry-forward untracked directories bump to **36/31/31/24 days** at the 2026-09-17T18:22Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 2 new automated wiki commits in the 24-hour window (`3d95e56` daily update 2026-09-17 + `307e038` sources-sync 2026-09-17 thirty-fourth) bumped wiki HEAD `ac46732` → `307e038`; the 10-dirty-file baseline (down from the prior 11-dirty-file baseline) shows the `3d95e56` daily update cleared `index.md` + `sources/README.md` while `sources/literature.md` was newly re-touched; synthesis-layer impact is **none** because vault produced no new external evidence. The **2026-09-18T18:15Z fetch** is the **34th git-repo-1 fetch of the 2026-08-07 streak** + the **7th consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`, **7 calendar days of vault silence**); the **1 working-tree modification** at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) **persists uncommitted for 5 calendar days** at the 2026-09-18T18:15Z fetch without further changes; the 4 carry-forward untracked directories bump to **37/32/32/25 days** at the 2026-09-18T18:15Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 2 new automated wiki commits in the 24-hour window (`46a508d` daily update 2026-09-18 + `c6e81a5` sources-sync 2026-09-18 thirty-fifth) bumped wiki HEAD `307e038` → `c6e81a5`; the 11-dirty-file baseline (up from the prior 10-dirty-file baseline at 2026-09-17) shows the `46a508d` daily update re-touched the same synthesis-layer files while `sources/index.md` was newly re-touched and `sources/README.md` was cleared from the dirty list; synthesis-layer impact is **none** because vault produced no new external evidence. The **2026-09-19T18:04Z fetch** is the **35th git-repo-1 fetch of the 2026-08-07 streak** + the **8th consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`, **8 calendar days of vault silence**); the **1 working-tree modification** at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) **persists uncommitted for 6 calendar days** at the 2026-09-19T18:04Z fetch without further changes; the 4 carry-forward untracked directories bump to **38/33/33/26 days** at the 2026-09-19T18:04Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 2 new automated wiki commits in the 24-hour window (`1ba0fb1` sources-sync 2026-09-19 thirty-sixth + `6e2a733` daily update 2026-09-19) bumped wiki HEAD `c6e81a5` → `6e2a733`; the **5-dirty-file baseline** (down from the prior 11-dirty-file baseline at 2026-09-18) shows the `6e2a733` daily update cycle cleared the prior dirty list (the standard 15-file cycle staging+committing 11 of the previously-dirty files) and 5 files were re-touched in the working tree post-commit (`M .last-update.json` + `M sources/hackernews.md` + `M sources/index.md` + `M sources/web-search.md` + `M themes.md`); synthesis-layer impact is **none** because vault produced no new external evidence. The **2026-09-20T18:07Z fetch** is the **36th git-repo-1 fetch of the 2026-08-07 streak** + the **9th consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`, **9 calendar days of vault silence**); the **1 working-tree modification** at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) **persists uncommitted for 7 calendar days** at the 2026-09-20T18:07Z fetch without further changes; the 4 carry-forward untracked directories bump to **39/34/34/27 days** at the 2026-09-20T18:07Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 2 new automated wiki commits in the 24-hour window (`95f286d` sources-sync 2026-09-20 thirty-seventh + `49e3f63` daily update 2026-09-20) bumped wiki HEAD `6e2a733` → `95f286d`; the **12-dirty-file baseline** (up from the prior 5-dirty-file baseline at 2026-09-19) shows the `49e3f63` daily update cycle cleared the prior 5-dirty-file baseline (the standard 15-file cycle per `git show --stat 49e3f63`) and the `95f286d` sources-sync re-touched `sources/nocodb.md` + `sources/ragflow.md` + `sources/seafile.md` + `sources/wikijs.md` + `sources/openwiki-version-drift.md`, while the synthesis-side write path re-touched `quickstart.md` + `themes.md` + `sources/README.md` + `sources/index.md` + `sources/hackernews.md` + `sources/web-search.md` + `sources/git-repo.md`; synthesis-layer impact is **none** because vault produced no new external evidence. The **2026-09-21T18:17Z fetch** is the **37th git-repo-1 fetch of the 2026-08-07 streak** + the **10th consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`, **10 calendar days of vault silence**); the **1 working-tree modification** at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) **persists uncommitted for 8 calendar days** at the 2026-09-21T18:17Z fetch without further changes; the 4 carry-forward untracked directories bump to **40/35/35/28 days** at the 2026-09-21T18:17Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 2 new automated wiki commits in the 24-hour window (`d5a2b15` sources-sync 2026-09-21 thirty-eighth + `5cc20ce` daily update 2026-09-21) bumped wiki HEAD `95f286d` → `d5a2b15`; the **10-dirty-file baseline** (down from the prior 12-dirty-file baseline at 2026-09-20) shows the `5cc20ce` daily update cycle cleared 6 files that the prior daily update had not been able to clean (`index.md` + `sources/README.md` + `sources/git-repo.md` + `sources/openwiki-version-drift.md` + `themes/05-robin-research.md` + `themes/index.md`) and the `d5a2b15` sources-sync re-touched `sources/nocodb.md` + `sources/ragflow.md` + `sources/seafile.md` + `sources/wikijs.md`, while the synthesis-side write path re-touched `quickstart.md` + `themes.md` + `sources/index.md` + `sources/hackernews.md` + `sources/web-search.md`; synthesis-layer impact is **none** because vault produced no new external evidence. The **2026-09-22T18:08Z fetch** is the **38th git-repo-1 fetch of the 2026-08-07 streak** + the **11th consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`, **11 calendar days of vault silence**); the **1 working-tree modification** at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) **persists uncommitted for 9 calendar days** at the 2026-09-22T18:08Z fetch without further changes; the 4 carry-forward untracked directories bump to **41/36/36/29 days** at the 2026-09-22T18:08Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 2 new automated wiki commits in the 24-hour window (`4ee7fc1` sources-sync 2026-09-22 thirty-ninth + `4e257c9` daily update 2026-09-22) bumped wiki HEAD `d5a2b15` → `4ee7fc1`; the **8-dirty-file baseline** (down from the prior 10-dirty-file baseline at 2026-09-21) shows the `4e257c9` daily update cycle cleared 7 files that the prior daily update had not been able to clean (`index.md` + `quickstart.md` + `sources/README.md` + `sources/git-repo.md` + `themes.md` + `themes/05-robin-research.md` + `themes/index.md`) and the `4ee7fc1` sources-sync re-touched `sources/nocodb.md` + `sources/ragflow.md` + `sources/seafile.md` + `sources/wikijs.md`; synthesis-layer impact is **none** because vault produced no new external evidence. The **2026-09-23T18:10Z fetch** is the **39th git-repo-1 fetch of the 2026-08-07 streak** + the **12th consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`, **12 calendar days of vault silence**); the **1 working-tree modification** at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) **persists uncommitted for 10 calendar days** at the 2026-09-23T18:10Z fetch without further changes; the 4 carry-forward untracked directories bump to **42/37/37/30 days** at the 2026-09-23T18:10Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 2 new automated wiki commits in the 24-hour window (`6aa1db2` sources-sync 2026-09-23 fortieth + `4c145e2` daily update 2026-09-23) bumped wiki HEAD `4ee7fc1` → `6aa1db2`; the **10-dirty-file baseline** (up from the prior 8-dirty-file baseline at 2026-09-22) shows the `4c145e2` daily update cycle cleared 6 files but the `6aa1db2` sources-sync re-touched `sources/nocodb.md` + `sources/ragflow.md` + `sources/seafile.md` + `sources/wikijs.md` and the post-sources-sync synthesis-side write path re-touched `quickstart.md` + `sources/README.md` + `sources/hackernews.md` + `sources/web-search.md` + `sources/index.md`; synthesis-layer impact is **none** because vault produced no new external evidence. The **2026-09-24T18:07Z fetch** is the **40th git-repo-1 fetch of the 2026-08-07 streak** + the **13th consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`, **13 calendar days of vault silence**); the **1 working-tree modification** at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) **persists uncommitted for 11 calendar days** at the 2026-09-24T18:07Z fetch without further changes; the 4 carry-forward untracked directories bump to **43/38/38/31 days** at the 2026-09-24T18:07Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 2 new automated wiki commits in the 24-hour window (`17e9faf` sources-sync 2026-09-24 forty-first + `dc1a9fb` daily update 2026-09-24) bumped wiki HEAD `6aa1db2` → `17e9fafc`; the **12-dirty-file baseline** (up from the prior 10-dirty-file baseline at 2026-09-23) shows the `dc1a9fb` daily update cycle cleared the standard 14-file cycle but the `17e9faf` sources-sync re-touched `sources/nocodb.md` + `sources/ragflow.md` + `sources/seafile.md` + `sources/wikijs.md` and the post-sources-sync synthesis-side write path re-touched `index.md` + `quickstart.md` + `sources/README.md` + `sources/hackernews.md` + `sources/index.md` + `sources/web-search.md` + `themes.md`; synthesis-layer impact is **none** because vault produced no new external evidence. The **2026-09-25T18:17Z fetch** is the **41st git-repo-1 fetch of the 2026-08-07 streak** + the **14th consecutive vault-silent fetch** after the Tomas 2026 + Vijakumaran 2026 resumption (vault HEAD unchanged at `09bec367`, **14 calendar days of vault silence**); the **1 working-tree modification** at `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) **persists uncommitted for 12 calendar days** at the 2026-09-25T18:17Z fetch without further changes; the 4 carry-forward untracked directories bump to **44/39/39/32 days** at the 2026-09-25T18:17Z fetch (the highest carry-forward durations of the 2026-08-07 streak); 2 new automated wiki commits in the 24-hour window (`f9bb2e5` sources-sync 2026-09-25 forty-second + `069eef3` daily update 2026-09-25) bumped wiki HEAD `17e9fafc` → `f9bb2e5e`; the **11-dirty-file baseline** (down from the prior 12-dirty-file baseline at 2026-09-24) shows the `069eef3` daily update cleared `sources/git-repo.md` from the dirty list (the `069eef3` daily update re-touched the standard 15-file cycle including `sources/git-repo.md` + `themes.md` + `themes/05-robin-research.md` + `themes/index.md`) while the `f9bb2e5` sources-sync re-touched `sources/nocodb.md` + `sources/ragflow.md` + `sources/seafile.md` + `sources/wikijs.md`; synthesis-layer impact is **none** because vault produced no new external evidence."
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tags: [theme, research, vault, deep-read, sales, crm, life-sciences, 2026-09-24, 2026-09-23, 2026-09-22, 2026-09-20, 2026-09-19, 2026-09-18, 2026-09-17, 2026-09-16, 2026-09-15, 2026-09-14, 2026-09-11, 2026-09-10, 2026-09-09, 2026-09-08, 2026-09-07, 2026-09-06, 2026-09-05, 2026-09-04, 2026-09-03, 2026-09-02, 2026-09-01, 2026-08-31, 2026-08-30, 2026-08-29, 2026-08-28, 2026-08-27, 2026-08-26, 2026-08-25, 2026-08-24, 2026-08-23, 2026-08-22, 2026-08-21, 2026-08-20, 2026-08-19, 2026-08-18, 2026-08-17, 2026-08-15, 2026-08-13, celvivo-app-note-2026, aiello-bagni-rc-cfd, tian-epicardium-mtor, kim-egain-3d-mea, ajongbolo-brain-organoid-review, tevonian-2026-vascularized-liver-mps, yang-2026-cardiac-organoid-review, shen-2026-vascularized-organoids-review, zhai-2026-3d-skin-pemphigus, yan-2024-tmem106b-sars-cov2-brain-organoid, stewart-2023-ba5-xbb-neurotropic-brain-organoid, nguyen-2024-jev-g4-australia-brain-organoid, aiello-2025-brain-organoid-reproducibility, miao-2025-vascularized-lung-gut-organoids, tomas-2026-hgsoc-parpi-spheroid-organoid, vijakumaran-2026-brain-organoid-ali-oxygen-engineering, brain-organoid-virology-cluster, celvivo-clinoreactor-cluster, vascularized-organoids, cardiac-organoids, skin-organoids, hgsc-ovarian-cancer-precision-medicine, celvivo-capital-v-parallel-subfolder, vault-silence-4d, vault-silence-5d, vault-silence-6d, vault-silence-7d, vault-silence-8d, vault-silence-9d, vault-silence-broken, vault-resumed-after-11d, flywheel-v4-auto-sink, third-5paper-cluster, twenty-first-sources-sync, twenty-second-sources-sync, twenty-third-sources-sync, twenty-fourth-sources-sync, twenty-fifth-sources-sync, twenty-sixth-sources-sync, twenty-seventh-sources-sync, twenty-eighth-sources-sync, twenty-ninth-sources-sync, thirtieth-sources-sync, thirty-first-sources-sync, thirty-second-sources-sync, thirty-third-sources-sync, thirty-fourth-sources-sync, thirty-fifth-sources-sync, thirty-sixth-sources-sync, thirty-seventh-sources-sync, thirty-eighth-sources-sync, thirty-ninth-sources-sync, review-templates-celvivo-commercial-confirmed-one-off, deepread-40240593-twelve-silent-fetches, deepread-40240593-thirteen-silent-fetches, deepread-40240593-fourteen-silent-fetches, deepread-40240593-fifteen-silent-fetches, deepread-40240593-sixteen-silent-fetches, deepread-40240593-seventeen-silent-fetches, deepread-40240593-eighteen-silent-fetches, deepread-40240593-nineteen-silent-fetches, deepread-40240593-twenty-silent-fetches, deepread-40240593-twenty-one-silent-fetches, deepread-40240593-twenty-two-silent-fetches, deepread-40240593-twenty-three-silent-fetches, deepread-40240593-twenty-four-silent-fetches, deepread-40240593-twenty-five-silent-fetches, deepread-40240593-twenty-six-silent-fetches, deepread-40240593-twenty-seven-silent-fetches, deepread-40240593-twenty-eight-silent-fetches, deepread-40240593-twenty-nine-silent-fetches, deepread-40240593-thirty-silent-fetches, moc-organoid-3d-culture-uncommitted-edit, moc-organoid-3d-culture-uncommitted-edit-3d, moc-organoid-3d-culture-uncommitted-edit-4d, moc-organoid-3d-culture-uncommitted-edit-5d, moc-organoid-3d-culture-uncommitted-edit-6d, moc-organoid-3d-culture-uncommitted-edit-7d, moc-organoid-3d-culture-uncommitted-edit-8d, moc-organoid-3d-culture-uncommitted-edit-9d, moc-organoid-3d-culture-uncommitted-edit-10d, moc-organoid-3d-culture-uncommitted-edit-11d, vault-working-tree-moc-modification-2026-09-13, vault-working-tree-moc-modification-2026-09-13-persists, thirty-first-git-repo-fetch, thirty-second-git-repo-fetch, thirty-third-git-repo-fetch, thirty-fourth-git-repo-fetch, thirty-fifth-git-repo-fetch, thirty-sixth-git-repo-fetch, thirty-seventh-git-repo-fetch, thirty-eighth-git-repo-fetch, thirty-ninth-git-repo-fetch, fortieth-git-repo-fetch, wiki-2-new-commits, wiki-6-new-commits, dirty-5-files-baseline-2026-09-19, dirty-8-files-baseline-2026-09-22, dirty-10-files-baseline-2026-09-21, dirty-10-files-baseline-2026-09-23, dirty-12-files-baseline-2026-09-20, dirty-12-files-baseline-2026-09-24, thirty-ninth-sources-sync-2026-09-22, fortieth-sources-sync-2026-09-23, forty-first-sources-sync-2026-09-24, thirty-eighth-sources-sync-2026-09-21, thirty-seventh-sources-sync-2026-09-20, thirty-sixth-sources-sync-2026-09-19, thirty-sixth-git-repo-fetch-2026-09-20, thirty-seventh-git-repo-fetch-2026-09-21, thirty-eighth-git-repo-fetch-2026-09-22, thirty-ninth-git-repo-fetch-2026-09-23, fortieth-git-repo-fetch-2026-09-24, vault-silent-13d-consecutive-fetch, vault-silent-12d-consecutive-fetch]
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timestamp: 2026-09-25T18:17:00Z
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---
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# Theme 5 · Robin's personal research (vendor deep reads + sales ammunition + CRM)
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This is the synthesis page for **Robin 个人研究项目** — the durable body of work Robin builds on the 4-vendor product line: vendor-paper deep reads, vendor whitepaper deep reads, sales ammunition (pricing + protocols + app notes), the China distributor map, the active CRM profile set, and the weekly work-rhythm snapshot. Output is fed back into the vendor themes ([`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) and [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md)) and into `/commitments.md`.
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## What this theme covers
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- **Research identity & scope:** 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed) + adjacent application domains (MSC spheroids, PDO, brain organoids, hMOs, assembloids, 3D bioprinting, electroporation).
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- **Knowledge substrate:** Obsidian vault rooted at `/mnt/c/Users/20864/.openclaw/workspace` (per `~/.openwiki/connectors/git-repo/config.json`), HEAD `1a81e485`, ahead of origin/main by 9 commits.
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- **Research process:** LDR master template + SOP-vs-implementation lessons (Tasevska / Raji / Bosnjakovic as canonical worked examples).
|
||
- **Research output:** 1,202 deep-read notes in `04-Literature/Deep-Reads/` + sales training material in `06-Sales/Content/Training-Materials/` + active CelVivo industrial-customers program.
|
||
- **CRM + market research:** 1 active distributor profile (`02-Clients/Agents/董慧群.md`) + 261-dealer China map + 11+ end-customer dossiers under `03-Resources/End-Customers/`.
|
||
- **Work-rhythm evidence:** 2026-07-16 vault mtime snapshot showing Robin's actual activity cadence across deep reads / training material / daily / weekly reports.
|
||
|
||
## Research output — data model
|
||
|
||
```mermaid
|
||
erDiagram
|
||
VAULT["Obsidian vault (a4fa5a32)"] ||--o{ DEEPREADS["Deep-read notes ~1,207"]
|
||
VAULT ||--o{ TRAIN["Sales training (CelVivo赋能培训 v1-v9)"]
|
||
VAULT ||--o{ SALES["Active sales pipeline (惠百生物 PO + 中间商)"]
|
||
VAULT ||--o{ CRM["Distributor profiles (董慧群 + 待补)"]
|
||
VAULT ||--o{ ENDCUST["End-customer dossiers (11+ 神经/中药/肿瘤所)"]
|
||
VAULT ||--o{ INDUSTRIAL["Industrial customers (CelVivo中国工业客户开发)"]
|
||
VAULT ||--o{ MEMORY["Daily + weekly reports (memory/ 147 .md)"]
|
||
VAULT ||--o{ ITX["ITX 24h host build (untracked)"]
|
||
VAULT ||--o{ MOC["MOCs (类器官与3D培养 first, +planned)"]
|
||
VAULT ||--o{ TEMPLATES["Templates (类器官IRB申请清单 v1.0, untracked)"]
|
||
|
||
DEEPREADS }o--|| VENDOR["Vendor mapping"]
|
||
VENDOR ||--|{ CelVivo["CelVivo (ClinoStar / ClinoReactor)"]
|
||
VENDOR ||--|{ ThreeBrain["3Brain (BioCAM / Accura-3D / CorePlate)"]
|
||
VENDOR ||--|{ Cellink["Cellink (BIO X / BIONOVA X / Lumen X)"]
|
||
VENDOR ||--|{ Femtobiomed["Femtobiomed (CellShot / TriArm / CellPick)"]
|
||
|
||
SALES }o--|| CelVivo
|
||
CRM }o--|| CelVivo
|
||
ENDCUST }o--|| ThreeBrain
|
||
INDUSTRIAL }o--|| CelVivo
|
||
TRAIN }o--|| CelVivo
|
||
```
|
||
|
||
The diagram shows Robin's research substrate: a single Obsidian vault with 8 buckets of artifacts, most of which are vendor-anchored to one of the 4 product lines. Vendor-anchored output flows out of the vault and into the canonical synthesis themes (`01` CelVivo / 3Brain; `02` Cellink; with Femtobiomed as adjacent cross-sell for both).
|
||
|
||
## Knowledge substrate: Obsidian vault
|
||
|
||
Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-09-22T18:08:00Z — 38th git-repo-1 fetch of the 2026-08-07 streak; the 2026-09-21T18:17Z fetch was the 37th fetch; the 2026-09-20T18:07Z fetch was the 36th fetch; the 2026-09-19T18:04Z fetch was the 35th fetch; the 2026-09-18T18:15Z fetch was the 34th fetch; the 2026-09-17T18:22Z fetch was the 33rd fetch; the 2026-09-16T18:18Z fetch was the 32nd fetch; the 2026-09-13T18:08Z fetch was the 31st fetch; the 2026-09-11T18:14Z fetch was the 29th fetch; the 2026-09-12T18:08Z fetch was the 30th fetch with vault HEAD unchanged at `09bec367` + wiki HEAD bumped `55d930f` → `7d...` between the 2 daily updates):
|
||
|
||
| Field | Value |
|
||
| --- | --- |
|
||
| Repo path | `/home/ldw/workspace` |
|
||
| Branch | `main` |
|
||
| HEAD | `09bec36702cdbd8ef1d2644919ca337248ae6bff` (vault HEAD bumped `391e4713` → `09bec367` at the 2026-09-11T18:14Z fetch — **vault silence streak BROKEN after 11 calendar days** with **2 new vault commits**: `1fd63019` 2026-09-10 (Tomas 2026 HGSC carboplatin/PARPi spheroid+organoid deep-read) + `09bec367` 2026-09-11 (Vijakumaran 2026 brain-organoid ALI oxygen engineering, **first v4 Flywheel auto-sink pipeline entry**); the 2026-09-01 + 2026-09-02 + 2026-09-03 + 2026-09-04 + 2026-09-05 + 2026-09-06 + 2026-09-07 + 2026-09-08 + 2026-09-09 fetches observed vault HEAD unchanged at `391e4713` for the 1st + 2nd + 3rd + 4th + 5th + 6th + 7th + 8th + 9th consecutive fetches since the 2026-08-31 THIRD consecutive 5-paper CelVivo LDR cluster, **9 calendar days of vault silence** at the 2026-09-09 fetch; the 2026-09-10 + 2026-09-11 fetches observed the vault-silence streak broken with 2 new vault commits; the 2026-09-12 + 2026-09-13 fetches observed vault HEAD unchanged at `09bec367` (2nd + 3rd consecutive vault-silent fetches after the resumption — the 2026-09-13T18:08Z fetch is the 2nd consecutive vault-silent fetch); the 2026-08-31 CelVivo cluster remains the prior-most-recent committed vault activity but is no longer the latest) |
|
||
| Ahead of origin/main | 37 commits new since 2026-08-03 fetch (+2 from 2026-09-09T18:11Z fetch — `1fd63019` Tomas 2026 + `09bec367` Vijakumaran 2026) |
|
||
| Auth | local path only — no remote, no credentials |
|
||
| Working-tree state | dirty (28 untracked files + 4 untracked directories — `celvivo_commercial/1331651_20260630_131201.pdf` + `templates/类器官IRB申请清单.md` + `deepread_40240593/` (7 subdirs, **29-day carry-forward** at 2026-09-22, was 28-day at 2026-09-21, was 27-day at 2026-09-20, was 26-day at 2026-09-19, was 23-day at 2026-09-16, was 20-day at 2026-09-13, **28 consecutive silent fetches** since the 2026-08-24/25 burst — working-folder pipeline hypothesis continuing to weaken; the 2026-08-31 burst did NOT route through `deepread_<slug>/` working folders, the 2026-09-10 + 2026-09-11 resumption did NOT route through them either, the 2026-09-13 + 2026-09-14 + 2026-09-15 + 2026-09-16 + 2026-09-17 + 2026-09-18 + 2026-09-19 + 2026-09-20 + 2026-09-21 + **2026-09-22** MOC-folder edits did NOT route through them either, the directory mtime is still 2026-08-24 16:31 +0800 — **28 fetches silent on directory mtime**) + `Review/zhou2023_computer_vision_microfluidics.md` (**41-day carry-forward** at the 2026-09-22T18:08Z fetch, **39 fetches silent**, **one-off interpretation confirmed at 2026-08-28 fetch** per the 2026-08-27 fetch confirmation, carrying forward unchanged at the 2026-08-29 + 2026-08-30 + 2026-08-31 + 2026-09-01 + 2026-09-02 + 2026-09-03 + 2026-09-04 + 2026-09-05 + 2026-09-06 + 2026-09-07 + 2026-09-08 + 2026-09-09 + 2026-09-10 + 2026-09-11 + 2026-09-12 + 2026-09-13 + 2026-09-14 + 2026-09-15 + 2026-09-16 + 2026-09-17 + 2026-09-18 + 2026-09-19 + 2026-09-20 + 2026-09-21 + **2026-09-22** fetches; the `celvivo_commercial/` + `templates/` entries are also **confirmed one-off alongside the `Review/` entry** at the 2026-08-28 fetch, both at **36-day carry-forward** + **36 fetches silent** at the 2026-09-22 fetch; all 3 entries remain **stale / not recurring carry-forward notes**) — **highest carry-forward durations of the 2026-08-07 streak**) + 1 working-tree modification: `M "04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md"` (mtime 2026-09-13 11:55:42 +0800 — Robin actively editing the MOC index file but not yet committed; first vault working-tree modification since the 2026-08-24/25 burst; the modification **persists uncommitted for 9 calendar days** at the 2026-09-22T18:08Z fetch without further changes; the 2026-09-13 MOC-folder edit is the first new edit-route observed since the 2026-08-24/25 `deepread_<slug>/` working-folder pipeline was abandoned at the 2026-08-31 cluster; the 2026-09-22 fetch is the **9th consecutive silent modification** — same mtime, same MOC file, no further working-tree movement) |
|
||
| Raw manifest | `~/.openwiki/connectors/git-repo/raw/2026-09-13T18-08-XX-XXXZ/manifest.json` (2026-09-13T18:08:XX Z; prior fetch was `2026-09-11T18-14-12-972Z`) |
|
||
| **Latest cluster (2026-09-10 / 2026-09-11, vault silence streak BROKEN)** | **2 new vault commits after the 11-day vault silence** — `1fd63019` 2026-09-10 `feat(literature): Tomas 2026 HGSC carboplatin/PARPi spheroid+organoid deep-read` (Western University; new file at `04-Literature/Deep-Reads/tomas-2026-hgsoc-carboplatin-parpi-spheroid-organoid.md`; **0 vendor callouts** — spheroid = ULA static plate, organoid = Cultrex BME, no bioreactor/spinner; **honest negative** for clinical-trial sequencing of PARPi-before-chemo in HRD patients) → `09bec367` 2026-09-11 `literature: 精读 NocoDB Id=3029 Air-liquid interface-centered oxygen engineering in human br (飞轮 v4 自动 sink)` (new file at `Literature/Deep-Reads/Organoid/vijakumaran2026-brain-organoid-ali-oxygen-engineering.md`; brain-organoid air-liquid interface oxygen engineering; **first paper routed through the v4 Flywheel auto-sink pipeline** — the v3 SOP was 9 steps per the 2026-08-25 `9aa2af4c` vendor-mapping retrofit, and the v4 auto-sink iterates the SOP with an automated commit/sink step). Both new papers route through the standard `04-Literature/Deep-Reads/<application-domain>/<DOI>.md` pattern but with **2 distinct path conventions**: Tomas 2026 uses the standard `04-Literature/Deep-Reads/` prefix (root-level pattern as in the 2026-08-23/24 cluster) while Vijakumaran 2026 uses the lowercase `Literature/Deep-Reads/Organoid/` prefix (consistent with the older 2026-08-16 Quintard 2024 + Guo 2026 entries). The 2026-08-31 THIRD consecutive 5-paper CelVivo LDR cluster (Stewart + Aiello + Nguyen + Miao + Yan) is now the **prior-most-recent committed vault activity**; the 2026-09-10 + 2026-09-11 resumption is the **latest** |
|
||
| **Prior latest cluster (2026-08-31, demoted to prior-most-recent at the 2026-09-11 fetch)** | **THIRD consecutive single-day 5-paper LDR burst** (`eb24ab72` Stewart 2023 Front Microbiol SARS-CoV-2 omicron BA.5/XBB neurotropic brain organoids → `030f31ed` Aiello 2025 EMBO reports reproducible brain organoids (CelVivo ApS co-author affiliation) → `fad7e21e` Nguyen 2024 npj Viruses JEV G4 2022 Australia brain organoids → `4fca0123` Miao 2025 Cell vascularized lung/gut organoids → `391e4713` Yan 2024 Cell Reports TMEM106B SARS-CoV-2 ACE2-independent brain organoids) — **all 5 files landed in the NEW `obsidian-vault/04-Literature/Deep-Reads/CelVivo/` subfolder (capital-V, parallel to the existing lowercase `04-Literature/Deep-Reads/Celvivo/` 142-file subfolder)**; Robin's **first parallel-naming deep-read subfolder convention**; subfolder semantics: QIMR Berghofer Suhrbier/Rawle viral-neurotropism brain-organoid line (Stewart + Nguyen + Yan) + CelVivo ApS co-authored reproducibility (Aiello) + vascularized lung/gut (Miao); 4 of 5 are brain organoids + 1 is vascularized lung/gut (Miao companion to the 2026-08-08 Miao 2025 v2 deep-read); the cluster did NOT receive the `9aa2af4c` vendor-mapping retrofit commit (no companion retrofit commit this cluster); carried forward from the 2026-08-31T18:09Z fetch through the 11-day vault-silence period. Combined with the 2026-08-23/24 + 2026-08-24/25 bursts = **15 LDR files in 8 calendar days** |
|
||
| **Latest uncommitted artifacts (2026-08-13 → 2026-09-22, multi-file, unchanged across the 2026-08-26 → 2026-09-22 fetches)** | `04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md` (carry-forward untracked from 2026-08-13, now at **41-day carry-forward** at the 2026-09-22 fetch — file mtime `2026-08-11 16:31:54 +0800` so mtime-based carry-forward is 41 days; first-observation-date-based carry-forward is 40 days; **structural signal confirmed as one-off** per `/sources/git-repo.md` Notable-entity entry — 39 consecutive fetches silent on the file; the entry remains a stale / not recurring carry-forward note) + **2 prior untracked directories added at the 2026-08-17 fetch**, still-uncommitted at the 2026-09-22 fetch (**36-day carry-forward** each — was 35-day at the 2026-09-21 fetch, 34-day at the 2026-09-20 fetch, 33-day at the 2026-09-19 fetch, 32-day at the 2026-09-18 fetch, 31-day at the 2026-09-17 fetch, 30-day at the 2026-09-16 fetch, 27-day at the 2026-09-13 fetch, 25-day at the 2026-09-11 fetch, 24-day at the 2026-09-09 fetch, 23-day at the 2026-09-08 fetch, 22-day at the 2026-09-07 fetch, 21-day at the 2026-09-06 fetch, 20-day at the 2026-09-05 fetch, 19-day at the 2026-09-04 fetch, 18-day at the 2026-09-03 fetch, 17-day at the 2026-09-02 fetch, 16-day at the 2026-09-01 fetch, 15-day at the 2026-08-31 fetch, 14-day at the 2026-08-30 fetch, 13-day at the 2026-08-29 fetch, 12-day at the 2026-08-28 fetch, 11-day at the 2026-08-27 fetch, 10-day at the 2026-08-26 fetch): `celvivo_commercial/1331651_20260630_131201.pdf` (6-30 quote PDF migrated into new folder; **confirmed one-off at 2026-08-28 fetch** carrying forward unchanged at 2026-08-29 + 2026-08-30 + 2026-08-31 + 2026-09-01 + 2026-09-02 + 2026-09-03 + 2026-09-04 + 2026-09-05 + 2026-09-06 + 2026-09-07 + 2026-09-08 + 2026-09-09 + 2026-09-10 + 2026-09-11 + 2026-09-12 + 2026-09-13 + 2026-09-14 + 2026-09-15 + 2026-09-16 + 2026-09-17 + 2026-09-18 + 2026-09-19 + 2026-09-20 + 2026-09-21 + **2026-09-22**) + `templates/类器官IRB申请清单.md` (180-line IRB application checklist derived from Guo 2026; Robin's first customer-facing template produced from a single deep-read — see the new Templates subtree below; **confirmed one-off at 2026-08-28 fetch** carrying forward unchanged at 2026-08-29 + 2026-08-30 + 2026-08-31 + 2026-09-01 + 2026-09-02 + 2026-09-03 + 2026-09-04 + 2026-09-05 + 2026-09-06 + 2026-09-07 + 2026-09-08 + 2026-09-09 + 2026-09-10 + 2026-09-11 + 2026-09-12 + 2026-09-13 + 2026-09-14 + 2026-09-15 + 2026-09-16 + 2026-09-17 + 2026-09-18 + 2026-09-19 + 2026-09-20 + 2026-09-21 + **2026-09-22**) + **1 new untracked directory added at the 2026-08-24 fetch** — `deepread_40240593/` (7 subdirs: 5 PMID-named `deepread_<PMID>/` + 2 slug-named `deepread_brain_organoid_fluid/` + `deepread_shear_stress_cs_os/` that exactly map to the Aiello + CelVivo App Note papers; the new directory is Robin's LDR pipeline intermediate-artifact workspace, see `/sources/git-repo.md` Notable-entity § "deepread_40240593/ pipeline workspace"; **29-day carry-forward** at 2026-09-22, directory mtime unchanged since 2026-08-24 16:31 +0800, the working-folder pipeline hypothesis continues to weaken — the absence of mtime movement across the 2026-08-25 + 2026-08-26 + 2026-08-27 + 2026-08-28 + 2026-08-29 + 2026-08-30 + 2026-08-31 + 2026-09-01 + 2026-09-02 + 2026-09-03 + 2026-09-04 + 2026-09-05 + 2026-09-06 + 2026-09-07 + 2026-09-08 + 2026-09-09 + 2026-09-10 + 2026-09-11 + 2026-09-12 + 2026-09-13 + 2026-09-14 + 2026-09-15 + 2026-09-16 + 2026-09-17 + 2026-09-18 + 2026-09-19 + 2026-09-20 + 2026-09-21 + **2026-09-22** fetches (28 consecutive silent fetches, plus the 2026-08-31 burst + the 2026-09-10 + 2026-09-11 resumption did NOT route through `deepread_<slug>/` working folders, **29 fetches silent on directory mtime**) suggests the pipeline may have been abandoned, formalized differently, or batched without intermediate commit) |
|
||
|
||
### Vault navigation index (top-level folders)
|
||
|
||
| Dir | Purpose | Size hint |
|
||
| --- | --- | --- |
|
||
| `01-Active-Sales/` | Active sales pipeline (board + per-account) | 6 .md |
|
||
| `02-Active-Deals/` | Deal-level active docs | 1 .md |
|
||
| `02-Clients/`, `02-Contacts/` | Client & contact records | sparse |
|
||
| `03-Product/` | Product briefs (e.g. 3Brain-Maxwell comparison) | 1 .md |
|
||
| `03-Resources/Agents/` | Distributor / agent profiles | a handful |
|
||
| `03-Resources/End-Customers/` | End-customer dossiers (3Brain MEA accounts, etc.) | 11+ .md |
|
||
| `03-Resources/ITX-24h-Host/` | Personal 24h Hermes-Agent host build config (2026-07-31 untracked) | 1 .md |
|
||
| `04-Literature/` | Paper deep-reads + curated vendor PDFs | see breakdown below |
|
||
| `05-Documents/Contracts/` | Signed/pending contracts (Celvivo subfolder) | — |
|
||
| `05-Documents/Products/` | Vendor-facing product docs (Celvivo/Industrial-Customers) | — |
|
||
| `05-Documents/{Proposals,Quotes,Visit-Plans}/` | Active commercial docs | — |
|
||
| `05-Products/` | In-house product briefs (MappingLab family) | 2 .md |
|
||
| `06-Sales/Competitors/` | Competitor tracking | — |
|
||
| `06-Sales/Configurations/` | Product configurations | — |
|
||
| `06-Sales/Content/{FAQ,Pain-Points,PPT-Scripts,Success-Stories,Training-Materials,推文模板}/` | Sales content library | — |
|
||
| `06-Sales/{Price-List,Product-Mapping,Recommendation-Engine}/` | Sales tooling | — |
|
||
| `99-Templates/` | Reusable Obsidian templates | 14 .md |
|
||
| `memory/` | Daily reports, weekly digests, `.dreams`, archive | 147 .md |
|
||
|
||
### `04-Literature/Deep-Reads/` breakdown
|
||
|
||
| Subfolder | .md count | Vendor / scope |
|
||
| --- | ---: | --- |
|
||
| `Organoid/` | 661 (+2 from 2026-08-16 — Quintard 2024 Nat Commun microfluidic vascularized organoid chip + Guo 2026 Front Cell Dev Biol organoid ethics systematic review) | broad organoid literature |
|
||
| `Celvivo/` | 142 | CelVivo vendor + CelVivo-adjacent papers |
|
||
| `3Brain/` | 136 | 3Brain vendor + 3Brain-adjacent papers |
|
||
| `Cellink/` | 129 | Cellink vendor + Cellink-adjacent papers |
|
||
| `Organoid-List/` | 51 | curated organoid reading lists |
|
||
| `Product-Reports/` | 38 | vendor product reports |
|
||
| `04-Literature/Deep-Reads/` root | +6 from 2026-08-23/24 + 2026-09-10 single-shot LDR bursts (CelVivo App Note + Aiello + Tian + Kim + Ajongbolo from 2026-08-23/24 + **Tomas 2026 HGSC carboplatin/PARPi spheroid+organoid from the 2026-09-10 vault commit `1fd63019`** — Western University; **0 vendor callouts**) — **non-standard pattern** vs prior per-vendor subfolder discipline; **2026-09-13T18:08Z fetch observed 1 working-tree modification** at `MOCs/MOC-类器官与3D培养.md` (mtime 2026-09-13 11:55:42 +0800) — Robin actively editing MOC index but not yet committed; the MOC working-tree modification is the first vault-side artifact change since the 2026-08-31 burst |
|
||
| `Vascularized-Organoids/` | 2 (NEW 2026-08-25 subfolder — Tevonian + Shen vascularized liver MPS / organoid review) | vascularized organoid (Tevonian primary + Shen review) |
|
||
| `Cardiac-Organoids/` | 1 (NEW 2026-08-25 subfolder — Yang cardiac organoid review) | cardiac organoid |
|
||
| `Skin-Organoids/` | 1 (NEW 2026-08-25 subfolder — Zhai 3D skin pemphigus) | autoimmune dermatology + 3D skin (net-new application domain) |
|
||
| `CelVivo/` (capital-V, parallel to lowercase `Celvivo/`) | 5 (NEW 2026-08-31 subfolder — `stewart-2023-ba5-xbb-neurotropic-brain-organoids.md` + `aiello-2025-brain-organoid-reproducibility.md` + `nguyen-2024-jev-g4-2022-australia-brain-organoids.md` + `miao-2025-vascularized-lung-gut-organoids.md` + `yan-2024-tmem106b-sars-cov2-ace2-independent.md`; all 5 single-shot LDR entries committed 2026-08-31 13:05-13:42 +0800; **4 of 5 are brain organoids** for viral-neurotropism modeling (QIMR Berghofer Suhrbier/Rawle research line) + **1 is vascularized lung/gut** (Miao); Robin's first parallel-naming deep-read subfolder convention; subfolder sits at `obsidian-vault/04-Literature/Deep-Reads/CelVivo/` parallel to lowercase `04-Literature/Deep-Reads/Celvivo/`; first LDR cluster **exclusively CelVivo-anchored** since the 2026-08-23/24 + 2026-08-24/25 clusters were partially vendor-distributed) | CelVivo ClinoStar / ClinoReactor brain organoid infectious-disease + reproducibility |
|
||
| `Brain/` | 11 | brain organoid focus |
|
||
| `Brain-Tumor/` | 9 | brain tumor organoid |
|
||
| `Cancer/` | 6 | cancer organoid |
|
||
| `Liver/` | 7 | liver organoid / HepG2 (Liang 2026 4-commit LDR cycle 2026-08-12) |
|
||
| `Other/` | 6 | uncategorised |
|
||
| `RegenMed/` | 1 | Ronawk Bio-Block MSC 4-week (added 2026-07-28) |
|
||
| `3Brain MEA/` | 3 | 3Brain HD-MEA papers |
|
||
| `Cardiac/` | 2 | cardiac organoid |
|
||
| `Kidney/` | 2 | kidney organoid |
|
||
| `Retinal/` | 1 | retinal organoid |
|
||
| `Microbioreactor/` | 1 | Rosero 2026 Front Bioeng Biotechnol (added 2026-08-07) |
|
||
| `Cells/` | 1 | Fernandez Vallone 2026 Cells THSDC (added 2026-08-08) |
|
||
| `Review/` | 1 | Zhou 2023 computer vision + microfluidics (added 2026-08-13, **untracked**, **10-day carry-forward** at 2026-08-21 fetch (was 9-day at 2026-08-20) — **8 fetches silent** — structural signal continuing to weaken; **11-day carry-forward** at 2026-08-22 fetch — **9 fetches silent**; **12-day carry-forward** at 2026-08-23 fetch — **10 fetches silent**; **13-day carry-forward** at 2026-08-24 fetch — **11 fetches silent**; **14-day carry-forward** at 2026-08-25 fetch — **12 fetches silent**; **15-day carry-forward** at 2026-08-26 fetch — **13 fetches silent**; **16-day carry-forward** at 2026-08-27 fetch — **14 fetches silent** — **confirmed one-off interpretation at 2026-08-27 fetch** per the parallel `Review/` downgrade in `/sources/git-repo.md`; **17-day carry-forward** at 2026-08-28 fetch — **15 fetches silent** — **demoted to "stale / not recurring" carry-forward note** at the 2026-08-28 fetch; **18-day carry-forward** at 2026-08-29 fetch — **16 fetches silent** — carries forward unchanged at the 2026-08-29 fetch, the 2026-08-28 demotion still standing; **19-day carry-forward** at 2026-08-30 fetch — **17 fetches silent** — carries forward unchanged at the 2026-08-30 fetch, the 2026-08-28 demotion still standing; **20-day carry-forward** at 2026-08-31 fetch — **18 fetches silent** — carries forward unchanged at the 2026-08-31 fetch, the 2026-08-28 demotion still standing; **21-day carry-forward** at 2026-09-01 fetch — **19 fetches silent** — carries forward unchanged at the 2026-09-01 fetch, the 2026-08-28 demotion still standing; **22-day carry-forward** at 2026-09-02 fetch — **20 fetches silent** — carries forward unchanged at the 2026-09-02 fetch, the 2026-08-28 demotion still standing; **23-day carry-forward** at 2026-09-03 fetch — **21 fetches silent** — carries forward unchanged at the 2026-09-03 fetch, the 2026-08-28 demotion still standing; **24-day carry-forward** at 2026-09-04 fetch — **22 fetches silent** — carries forward unchanged at the 2026-09-04 fetch, the 2026-08-28 demotion still standing; **25-day carry-forward** at 2026-09-05 fetch — **23 fetches silent** — carries forward unchanged at the 2026-09-05 fetch, the 2026-08-28 demotion still standing; **26-day carry-forward** at 2026-09-06 fetch — **24 fetches silent** — carries forward unchanged at the 2026-09-06 fetch, the 2026-08-28 demotion still standing; **27-day carry-forward** at 2026-09-07 fetch — **25 fetches silent** — carries forward unchanged at the 2026-09-07 fetch, the 2026-08-28 demotion still standing; **28-day carry-forward** at 2026-09-08 fetch — **26 fetches silent** — carries forward unchanged at the 2026-09-08 fetch, the 2026-08-28 demotion still standing; **29-day carry-forward** at 2026-09-09 fetch — **27 fetches silent** — carries forward unchanged at the 2026-09-09 fetch, the 2026-08-28 demotion still standing; **30-day carry-forward** at 2026-09-11 fetch — **28 fetches silent** — carries forward unchanged at the 2026-09-11 fetch, the 2026-08-28 demotion still standing; **31-day carry-forward** at 2026-09-12 fetch — **29 fetches silent** — carries forward unchanged at the 2026-09-12 fetch; **32-day carry-forward** at 2026-09-13 fetch — **30 fetches silent** — carries forward unchanged at the 2026-09-13 fetch, the 2026-08-28 demotion still standing; entry is a stale carry-forward note; **35-day carry-forward** at the 2026-09-16T18:18Z fetch — **33 fetches silent** — carries forward unchanged at the 2026-09-14 + 2026-09-15 + **2026-09-16** fetches, the 2026-08-28 demotion still standing; entry is a stale carry-forward note; **38-day carry-forward** at the 2026-09-19T18:04Z fetch — **36 fetches silent** — carries forward unchanged at the 2026-09-17 + 2026-09-18 + **2026-09-19** fetches, the 2026-08-28 demotion still standing; entry is a stale carry-forward note; **39-day carry-forward** at the 2026-09-20T18:07Z fetch — **37 fetches silent** — carries forward unchanged at the 2026-09-20 fetch, the 2026-08-28 demotion still standing; entry is a stale carry-forward note; **40-day carry-forward** at the 2026-09-21T18:17Z fetch — **38 fetches silent** — carries forward unchanged at the 2026-09-21 fetch, the 2026-08-28 demotion still standing; entry is a stale carry-forward note; **41-day carry-forward** at the 2026-09-22T18:08Z fetch — **39 fetches silent** — carries forward unchanged at the 2026-09-22 fetch, the 2026-08-28 demotion still standing; entry is a stale carry-forward note; **highest carry-forward duration of the 2026-08-07 streak**) |
|
||
| `Templates/` | 1 | `类器官IRB申请清单.md` v1.0 (2026-08-16, derived from Guo 2026 ethics deep-read, **untracked**; first customer-facing template produced from a single deep-read; **5-day carry-forward** at 2026-08-21 fetch — was 4-day at 2026-08-20; **6-day carry-forward** at 2026-08-22 fetch; **7-day carry-forward** at 2026-08-23 fetch; **8-day carry-forward** at 2026-08-24 fetch; **9-day carry-forward** at 2026-08-25 fetch; **10-day carry-forward** at 2026-08-26 fetch; **11-day carry-forward** at 2026-08-27 fetch — **approaching confirmed one-off interpretation alongside the `Review/` entry**; **12-day carry-forward** at 2026-08-28 fetch — **11 fetches silent** — **now confirmed one-off alongside the `Review/` + `CelVivo-commercial/` entries** at the 2026-08-28 fetch; **13-day carry-forward** at 2026-08-29 fetch — **12 fetches silent** — carries forward unchanged at the 2026-08-29 fetch, the 2026-08-28 confirmation still standing; **14-day carry-forward** at 2026-08-30 fetch — **13 fetches silent** — carries forward unchanged at the 2026-08-30 fetch, the 2026-08-28 confirmation still standing; **15-day carry-forward** at 2026-08-31 fetch — **14 fetches silent** — carries forward unchanged at the 2026-08-31 fetch, the 2026-08-28 confirmation still standing; **16-day carry-forward** at 2026-09-01 fetch — **15 fetches silent** — carries forward unchanged at the 2026-09-01 fetch, the 2026-08-28 confirmation still standing; **17-day carry-forward** at 2026-09-02 fetch — **16 fetches silent** — carries forward unchanged at the 2026-09-02 fetch, the 2026-08-28 confirmation still standing; **18-day carry-forward** at 2026-09-03 fetch — **17 fetches silent** — carries forward unchanged at the 2026-09-03 fetch, the 2026-08-28 confirmation still standing; **19-day carry-forward** at 2026-09-04 fetch — **18 fetches silent** — carries forward unchanged at the 2026-09-04 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; **20-day carry-forward** at 2026-09-05 fetch — **19 fetches silent** — carries forward unchanged at the 2026-09-05 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; **21-day carry-forward** at 2026-09-06 fetch — **20 fetches silent** — carries forward unchanged at the 2026-09-06 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; **22-day carry-forward** at 2026-09-07 fetch — **21 fetches silent** — carries forward unchanged at the 2026-09-07 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; **23-day carry-forward** at 2026-09-08 fetch — **22 fetches silent** — carries forward unchanged at the 2026-09-08 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; **24-day carry-forward** at 2026-09-09 fetch — **23 fetches silent** — carries forward unchanged at the 2026-09-09 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; **25-day carry-forward** at 2026-09-11 fetch — **24 fetches silent** — carries forward unchanged at the 2026-09-11 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; **30-day carry-forward** at the 2026-09-16T18:18Z fetch — **30 fetches silent** — carries forward unchanged at the 2026-09-12 + 2026-09-13 + 2026-09-14 + 2026-09-15 + **2026-09-16** fetches, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; **33-day carry-forward** at the 2026-09-19T18:04Z fetch — **33 fetches silent** — carries forward unchanged at the 2026-09-17 + 2026-09-18 + **2026-09-19** fetches, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; **34-day carry-forward** at the 2026-09-20T18:07Z fetch — **34 fetches silent** — carries forward unchanged at the 2026-09-20 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; **35-day carry-forward** at the 2026-09-21T18:17Z fetch — **35 fetches silent** — carries forward unchanged at the 2026-09-21 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; **36-day carry-forward** at the 2026-09-22T18:08Z fetch — **36 fetches silent** — carries forward unchanged at the 2026-09-22 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; **highest carry-forward duration of the 2026-08-07 streak**) |
|
||
| `CelVivo-commercial/` | 1 | `1331651_20260630_131201.pdf` (2026-06-30 quote PDF migrated into new folder 2026-08-17, **untracked**; **5-day carry-forward** at 2026-08-21 fetch — was 4-day at 2026-08-20; **6-day carry-forward** at 2026-08-22 fetch; **7-day carry-forward** at 2026-08-23 fetch; **8-day carry-forward** at 2026-08-24 fetch; **9-day carry-forward** at 2026-08-25 fetch; **10-day carry-forward** at 2026-08-26 fetch; **11-day carry-forward** at 2026-08-27 fetch — **approaching confirmed one-off interpretation alongside the `Review/` + `Templates/` entries**; **12-day carry-forward** at 2026-08-28 fetch — **11 fetches silent** — **now confirmed one-off alongside the `Review/` + `Templates/` entries** at the 2026-08-28 fetch; **13-day carry-forward** at 2026-08-29 fetch — **12 fetches silent** — carries forward unchanged at the 2026-08-29 fetch, the 2026-08-28 confirmation still standing; **14-day carry-forward** at 2026-08-30 fetch — **13 fetches silent** — carries forward unchanged at the 2026-08-30 fetch, the 2026-08-28 confirmation still standing; **15-day carry-forward** at 2026-08-31 fetch — **14 fetches silent** — carries forward unchanged at the 2026-08-31 fetch, the 2026-08-28 confirmation still standing; **16-day carry-forward** at 2026-09-01 fetch — **15 fetches silent** — carries forward unchanged at the 2026-09-01 fetch, the 2026-08-28 confirmation still standing; **17-day carry-forward** at 2026-09-02 fetch — **16 fetches silent** — carries forward unchanged at the 2026-09-02 fetch, the 2026-08-28 confirmation still standing; **18-day carry-forward** at 2026-09-03 fetch — **17 fetches silent** — carries forward unchanged at the 2026-09-03 fetch, the 2026-08-28 confirmation still standing; **19-day carry-forward** at 2026-09-04 fetch — **18 fetches silent** — carries forward unchanged at the 2026-09-04 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; **20-day carry-forward** at 2026-09-05 fetch — **19 fetches silent** — carries forward unchanged at the 2026-09-05 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; **21-day carry-forward** at 2026-09-06 fetch — **20 fetches silent** — carries forward unchanged at the 2026-09-06 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; **22-day carry-forward** at 2026-09-07 fetch — **21 fetches silent** — carries forward unchanged at the 2026-09-07 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; **23-day carry-forward** at 2026-09-08 fetch — **22 fetches silent** — carries forward unchanged at the 2026-09-08 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; **24-day carry-forward** at 2026-09-09 fetch — **23 fetches silent** — carries forward unchanged at the 2026-09-09 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; **25-day carry-forward** at 2026-09-11 fetch — **24 fetches silent** — carries forward unchanged at the 2026-09-11 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; **26-day carry-forward** at 2026-09-12 fetch — **25 fetches silent** — carries forward unchanged at the 2026-09-12 fetch; **27-day carry-forward** at 2026-09-13 fetch — **26 fetches silent** — carries forward unchanged at the 2026-09-13 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; **30-day carry-forward** at the 2026-09-16T18:18Z fetch — **30 fetches silent** — carries forward unchanged at the 2026-09-14 + 2026-09-15 + **2026-09-16** fetches, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; **33-day carry-forward** at the 2026-09-19T18:04Z fetch — **33 fetches silent** — carries forward unchanged at the 2026-09-17 + 2026-09-18 + **2026-09-19** fetches, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; **34-day carry-forward** at the 2026-09-20T18:07Z fetch — **34 fetches silent** — carries forward unchanged at the 2026-09-20 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; **35-day carry-forward** at the 2026-09-21T18:17Z fetch — **35 fetches silent** — carries forward unchanged at the 2026-09-21 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; **36-day carry-forward** at the 2026-09-22T18:08Z fetch — **36 fetches silent** — carries forward unchanged at the 2026-09-22 fetch, the 2026-08-28 confirmation still standing; entry is a stale carry-forward note; **highest carry-forward duration of the 2026-08-07 streak**) |
|
||
|
||
Total ≈ 1,211 deep-read notes on `main` (+5 new LDR files from the 2026-08-31 CelVivo-cluster on top of +4 from the 2026-08-24/25 cluster + +5 from the 2026-08-23/24 single-shot LDR burst + +2 from the 2026-08-16 Quintard 2024 + Guo 2026 clusters; the 5th 2026-08-25 commit `9aa2af4c` is an in-place `M` touch on Tevonian + Yang files, not a new file). The 4 vendor subfolders (Celvivo / 3Brain / Cellink / Organoid) cover the canonical product KB per the wiki goal focus areas. The new `templates/` folder signals Robin may be formalizing customer-facing deliverables (checklists / templates / sales scripts) as a separate vault subtree — the IRB application checklist is the first such artifact. The 2026-08-31 cluster creates the **NEW `CelVivo/` (capital-V) parallel subfolder** — Robin's first parallel-naming deep-read subfolder convention.
|
||
|
||
## Literature deep-read (LDR) pipeline
|
||
|
||
The 4-27 SOP (referenced from `/sources/ldr-report-template.md` and `/sources/2026-07-27-4-27-sop-vs-implementation.md`) is the canonical research workflow Robin uses to convert a vendor-paper PDF into a publishable, indexed, cross-system deep read.
|
||
|
||
```mermaid
|
||
stateDiagram-v2
|
||
[*] --> PubmedVerify: Id / DOI / PMID / PDF
|
||
PubmedVerify --> PDFPull: PubMed eSummary 验真
|
||
PDFPull --> ImgExtract: ragflow_direct_download.py / direct path
|
||
ImgExtract --> VisionReview: PyMuPDF xref dedup + 30KB + p1 logo
|
||
VisionReview --> ReportWrite: Ollama qwen2.5vl:7b (降级 if 服务宕)
|
||
ReportWrite --> SeaFileUpload: 5 段模板 (做了什么 / 3 发现 / 4 维对接 / 局限 / 转发语)
|
||
SeaFileUpload --> WikiPublish: PDF + 3 真图 → ?dl=1
|
||
WikiPublish --> NocoDB: GraphQL 5-orderBy union
|
||
NocoDB --> Commit: NocoDB v1 + JSON body (PATCH preferred)
|
||
Commit --> [*]: OpenWiki git commit + Gitea push
|
||
note right of VisionReview
|
||
2026-07-17 起 Ollama 服务宕
|
||
视觉审核降级 → 人工肉眼
|
||
end note
|
||
note right of NocoDB
|
||
Cellink 库 "已精读" SingleSelect options=[]
|
||
PATCH 失败, 在精读摘要里写
|
||
end note
|
||
```
|
||
|
||
The state diagram shows the canonical LDR pipeline: PDF → images → report → SeaFile → Wiki.js → NocoDB → commit. Two known operational degradations are called out: the Ollama visual-review step falls back to human review since 2026-07-17 (see [`/themes/04-local-llm.md`](/themes/04-local-llm.md)), and the Cellink library `已精读` SingleSelect is a NocoDB bug that blocks PATCH (workaround documented in the SOP-vs-implementation file).
|
||
|
||
### LDR SOP — 8 铁律 + 3 trigger modes + 5-section report
|
||
|
||
From [`/sources/ldr-report-template.md`](/sources/ldr-report-template.md) (Robin 7-27 实战版):
|
||
|
||
| 铁律 | 出处 | 实操 |
|
||
| --- | --- | --- |
|
||
| 1. PDF 全文必传 (SeaFile 永久链接, `?dl=1` 后缀) | 7-27 教训 | `upload.py` 上传 PDF, `?dl=1` 写 link |
|
||
| 2. PyMuPDF xref 去重 + 30KB 过滤 + p1 logo 剔除 | 7-27 教训 (Tasevska p1 logo) | `extract_image(xref)` per page, MD5 dedup |
|
||
| 3. 9 项强制 + 创新点/局限性/学术启示 3 段 | 7-27 教训 (2 篇缺 3 段) | 模板 §3 |
|
||
| 4. SeaFile URL hostname `fb.biokingdom.top` | 7-27 教训 (5 URL 错) | 验证 share-link 真能开 |
|
||
| 5. NocoDB v1 + JSON body (范本 v2 失败 3 次) | 7-27 Tasevska 入库 | `POST /api/v1/db/data/wzg1wtad/p2z4g0s687axyvu/{table_id}` |
|
||
| 6. 3 张真图 `![]()` (SeaFile URL), 不**只**文字图说啥 | 7-27 教训 | markdown image syntax (`alt text` + parenthesized URL) |
|
||
| 7. 报告路径 `journal-year-topic` (4-27 SOP 范本) | 7-27 教训 | `ejps-2025-hctz-sse-3d-printing` 风格 |
|
||
| 8. 精简 4 步 vs 完整 8 步按 Robin 信号自动判断 | 7-27 实战 | 模板 §2 |
|
||
|
||
**3 trigger modes:**
|
||
|
||
| Robin says | I take | 耗时 |
|
||
| --- | --- | --- |
|
||
| "精读吧" (any PDF, no publish intent) | **精简 4 步** (PDF → PyMuPDF → 写报告 → Obsidian) | 20-30 min |
|
||
| "A" / "发 wikijs" / "SeaFile 永久" / "入库" / "NocoDB" | **完整 8 步** (精简 4 步 + Ollama 视觉 + SeaFile + Wiki.js + NocoDB) | 45-60 min |
|
||
| "X 还是 Y" / "你定" / "继续下一篇" | **自动** | — |
|
||
|
||
**5-section report template (800–1500 chars):** 1. 做了什么 / 2. 3 关键发现 (每发现 3 段式表) / 3. 4 维产品对接 (CelVivo / 3Brain / Cellink / Femtobiomed) / 4. 局限 / 5. 转发语 + 落款 + PDF.
|
||
|
||
### Worked examples (canonical deep reads)
|
||
|
||
| Deep read | Vendor | Path | Synthesized at |
|
||
| --- | --- | --- | --- |
|
||
| Bosnjakovic 2025 bioRxiv | CelVivo | `04-Literature/Deep-Reads/Celvivo/Bosnjakovic_2025_PAH_3D_spheroid_CelVivo_ClinoStar_2026-07-27.md` | [`/sources/literature-cel-bosnjakovic-2025-pah-deepread.md`](/sources/literature-cel-bosnjakovic-2025-pah-deepread.md) |
|
||
| Raji 2026 Mol Psychiatry | 3Brain | `04-Literature/Deep-Reads/3Brain/Raji_2026_hMOs_dopaminergic_3Brain_MEA_2026-07-27.md` | [`/sources/literature-raji-2026-deepread.md`](/sources/literature-raji-2026-deepread.md) |
|
||
| Tasevska 2025 EJPS | Cellink | `04-Literature/Deep-Reads/Cellink/Tasevska_2025_HCTZ_3D_printed_extended_release_2026-07-27.md` | [`/sources/literature-tasevska-2025-deepread.md`](/sources/literature-tasevska-2025-deepread.md) |
|
||
| CelVivo 2026 brain organoid whitepaper (16 pp) | CelVivo | under `04-Literature/Deep-Reads/Celvivo/` | [`/sources/literature-celvivo-brain-whitepaper-2026.md`](/sources/literature-celvivo-brain-whitepaper-2026.md) |
|
||
| Hodge 2025 RegenMed | Ronawk Bio-Block (KB 0 命中) | `04-Literature/Deep-Reads/RegenMed/2026-07-28_Hodge_2025_RegenMed_MSC_3D_Bio-Block.md` | (not yet synthesized to `/sources/`) |
|
||
| Lee 2025 Front Vet Sci | (no vendor) | `04-Literature/Deep-Reads/Other/2026-07-28_Lee_2025_FrontVetSci_canine_MSC_3D_spheroid.md` | (not yet synthesized) |
|
||
| Parate 2020 SCRT | (no vendor) | `04-Literature/Deep-Reads/Other/2026-07-28_Parate_2020_SCRT_PEMF_MSC_paracrine_cartilage.md` | (not yet synthesized) |
|
||
| Sharma 2026 Cell Stem Cell (2026-08-08 flywheel-sync) | 3Brain + CelVivo adjacent | `/home/ldw/workspace/retinal_organoid_deep_read_2026-08-07.md` | [`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`](/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md) |
|
||
| Miao 2025 Cell v2 (2026-08-08 flywheel-sync) | CelVivo (ClinoStar rating 5) | `/home/ldw/workspace/Miao2025_Cell_v2.md` | [`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`](/sources/literature-miao-2025-cell-vascularization-v2-deepread.md) |
|
||
| Liu 2026 Nat Biomed Eng (2026-08-08 flywheel-sync) | 3Brain (HD-MEA rating 5) + Cellink (microlattice rating 5) | `/home/ldw/workspace/Liu2026_NBME_shape_conformal_organoid.md` | [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md) |
|
||
| Quintard 2024 Nat Commun (2026-08-16 vault LDR cluster) | CelVivo (ClinoStar rating 3 upstream) + Mimetas OrganoPlate (rating 4 direct) + Emulate Organ-Chip (rating 3) | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` | (not yet synthesized to `/sources/`) |
|
||
| Guo 2026 Front Cell Dev Biol (2026-08-16 vault LDR cluster) | CelVivo (ClinoStar rating 4 clinical-translation IRB) + Mimetas OrganoPlate (rating 4 co-culture ethics) + Emulate Organ-Chip (rating 3) | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` | (not yet synthesized to `/sources/`; derived customer-facing template at `templates/类器官IRB申请清单.md` v1.0) |
|
||
|
||
## Recent 30-day research output (mtime 2026-06-16 → 2026-08-12)
|
||
|
||
From [`/sources/literature.md`](/sources/literature.md) last sync, broken out by vendor and date:
|
||
|
||
| Date | DOI / slug | Vendor | Topic |
|
||
| --- | --- | --- | --- |
|
||
| 2026-08-16 | **Quintard 2024 Nat Commun + Guo 2026 Front Cell Dev Biol 7-commit LDR cluster** (commits `0fc8db24` + `290e9635` + `24c713de` + `4073abf4` Quintard + `2e6f5989` + `00f824f2` + `a4fa5a32` Guo) | **CelVivo adjacent + Mimetas OrganoPlate ⭐⭐⭐⭐ + Emulate Organ-Chip ⭐⭐⭐** (Quintard) / **CelVivo ClinoStar ⭐⭐⭐⭐ + Mimetas OrganoPlate ⭐⭐⭐⭐ + Emulate Organ-Chip ⭐⭐⭐** (Guo) | Quintard C et al. (2024) A microfluidic platform integrating functional vascularized organoids-on-chip (Nat Commun DOI 10.1038/s41467-024-45710-4, Wiki ID 1719/1720/1722, NocoDB Id 3297; 10 通道并行微流控 + hiPSC-BVO 30 天功能性灌注培养 + 跨类器官验证 [间充质球体 / BVO / 胰岛球体 / 肺类器官]; 血管层级化 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管, 壁剪切 27-2000 s⁻¹, 完美匹配人体毛细血管生理范围 50-1900 s⁻¹) + Guo Z & Zhang N (2026) Ethical review key considerations for organoid applications in biomedical research—a systematic review (Front Cell Dev Biol DOI 10.3389/fcell.2026.1721946, Wiki ID 1724, NocoDB Id 3298; 嘉兴市第一医院 + 嘉兴大学医学院视角; 类器官研究 IRB / 伦理审查 7 大强制要点系统综述 [样本来源/知情同意/数据隐私/共培养主体性/3R 动物福利/跨境监管/长期保存与终止使用] + 中国《人类遗传资源管理条例》+ 国际 ISSCR/GDPR/HIPAA 多国对照表). **Robin translated Guo 2026 into a customer-facing IRB application checklist template** (`templates/类器官IRB申请清单.md` v1.0 180 lines) — first customer-facing template produced from a single deep-read. |
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| 2026-08-25 | **SECOND consecutive single-day 5-paper LDR burst** (commits `089177a7` Tevonian + `583859a8` Yang + `9aa2af4c` vendor-mapping retrofit + `5907cdfc` Shen + `9d4767c7` Zhai) | **5-vendor product mapping retrofit on Tevonian + Yang** (CelVivo ClinoStar/ClinoReactor + Cellink BIO X + Mimetas OrganoPlate + 3Brain HD-MEA + FemtoBiomed CellShot) | **Tevonian 2026 Nat Commun vascularized liver MPS** (PMID 41634021, Wiki.js 1749; PDMS+fibrin+原代肝+HUVEC vascularized liver MPS, 14天 IR modeling, 单核细胞 infiltration enhancement; **first file in new Vascularized-Organoids/ subfolder**) + **Yang 2026 Stem Cell Res Ther cardiac organoid review** (PMID 41963991, Wiki.js 1750; 复旦 + InnoStar comprehensive review of hPSC cardiac organoid generation methods (FGF/PI3K/Wnt/BMP/Activin/RA 五大信号通路) + maturation protocols + disease modeling + regenerative medicine; **first file in new Cardiac-Organoids/ subfolder** — first new subfolder explicitly for an application-domain cluster) + **post-publish vendor-mapping retrofit commit `9aa2af4c`** on Tevonian + Yang (adds 5-vendor mapping table + 净化 Robin mentions; **first post-publish vendor-mapping retrofit step in Robin's LDR pipeline**, iterates the 8-step SOP to a 9-step SOP) + **Shen 2026 Chin Med J vascularized organoids review** (PMID 42268296, Wiki.js 1751; 华西医院 Chinese-language peer-reviewed systematic review of vascularized organoids 4 大策略 (共培养 + 转录因子诱导 + 微流控 + 生物材料支架) + 12 维对比 + 三大未来方向; second file in Vascularized-Organoids/ subfolder) + **Zhai 2026 Sci Adv 3D skin pemphigus** (PMID 41512055, Wiki.js 1752; 3D 打印 + 自组织 multilayer vascularized skin model for 天疱疮 autoimmune disease modeling + EGFR-targeted therapy + ML-assisted drug screening; **first file in new Skin-Organoids/ subfolder** — **net-new application domain** autoimmune dermatology + 3D skin). **3 NEW `04-Literature/Deep-Reads/` subfolders** created in a single day: `Vascularized-Organoids/` + `Cardiac-Organoids/` + `Skin-Organoids/` (Robin expands the deep-read folder taxonomy from ~19 → ~22, returning to per-vendor / per-application-domain subfolder discipline after the 2026-08-23/24 root-level non-standard pattern). **Combined with the 2026-08-23/24 5-paper burst = 10 LDR files in 48 hours = the largest sustained 2-day research output** in Robin's vault activity log. |
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| 2026-08-31 | **THIRD consecutive single-day 5-paper LDR burst** (commits `eb24ab72` Stewart + `030f31ed` Aiello + `fad7e21e` Nguyen + `4fca0123` Miao + `391e4713` Yan) — **all 5 exclusively CelVivo-anchored** (QIMR Berghofer Suhrbier/Rawle viral-neurotropism line + CelVivo ApS co-authored reproducibility + vascularized lung/gut) | **CelVivo ClinoStar / ClinoReactor** (direct platform validation across 4 brain organoid infectious-disease papers + 1 vascularized lung/gut paper; 1 paper — Aiello 2025 — has CelVivo ApS as a co-author affiliation, validating the ClinoStar/ClinoReactor platform as a reproducibility-benchmarking standard) | **Stewart 2023 Front Microbiol SARS-CoV-2 omicron BA.5/XBB neurotropic brain organoids** (DOI 10.3389/fmicb.2023.1320856; QIMR Berghofer Medical Research Institute + University of Queensland; K18-hACE2 mice + human brain organoids; MA1 infection cell count higher; **first file in new `CelVivo/` capital-V subfolder**) + **Aiello 2025 EMBO reports reproducible brain organoids** (DOI 10.1038/s44319-025-00619-x; 洛桑大学 + 罗马 Tor Vergata 大学 + 西北大学 (南非) + **CelVivo ApS (丹麦) co-author**; controlled fluid dynamics brain organoid reproducibility; CV <15% multi-batch + multi-cell-line) + **Nguyen 2024 npj Viruses JEV G4 2022 Australia brain organoids** (DOI 10.1038/s44298-024-00025-5; QIMR Berghofer + INRAE; JEV genotype 4 isolate characterization) + **Miao 2025 Cell vascularized lung/gut organoids** (DOI 10.1016/j.cell.2025.05.041; co-differentiation mesoderm+endoderm for organotypic vascularization; **companion to the 2026-08-08 flywheel-sync Miao 2025 v2 deep-read**) + **Yan 2024 Cell Reports TMEM106B SARS-CoV-2 ACE2-independent brain organoids** (DOI 10.1016/j.celrep.2024.114921; QIMR Berghofer; CRISPR 筛选鉴定 TMEM106B/硫酸乙酰肝素/内吞介导 ACE2 非依赖进入; 人源皮层脑类器官 CelVivo ClinoStar; MA1 神经毒力更强 in vitro but in vivo not consistent). **5 papers all single-shot LDR entries** (no v2/v3 SOP rewrite cycles this cluster); cluster does **NOT receive the `9aa2af4c` post-publish vendor-mapping retrofit commit** (no companion retrofit this cluster, unlike the 2026-08-24/25 cluster which had `9aa2af4c` as the 3rd of 5 commits). **1 NEW `04-Literature/Deep-Reads/` subfolder created**: `CelVivo/` (capital-V, parallel to existing lowercase `Celvivo/` subfolder) at `obsidian-vault/04-Literature/Deep-Reads/CelVivo/` — **Robin's first parallel-naming deep-read subfolder convention** (subfolder taxonomy from ~22 → ~23 in 8 calendar days). **Combined with 2026-08-23/24 + 2026-08-24/25 = 15 LDR files in 8 calendar days = the largest sustained 8-day research output** in Robin's vault activity log. Ends the 5-day vault silence streak from the 2026-08-24/25 burst. |
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| 2026-08-24 | **First 5-paper LDR burst in 24-hour window** (commits `ad4abcde` Ajongbolo + `5f02489a` Kim + `40b357b8` Tian + `f2118a62` Aiello + `fb017e4f` CelVivo App Note) | **CelVivo-aligned (3) + 3Brain-adjacent (1) + cardiac-epicardium (1)** | Ajongbolo 2025 Cells brain organoid review (PMID DOI 10.3390/cells14110842, Wiki.js 1743; canonical brain organoid + assembloid review with 3-tier taxonomy + 4-class characterization methodology) + Kim 2025 Nat Commun EGaIn liquid-metal 3D MEA (DOI 10.1038/s41467-024-55752-3, Wiki.js 1744; 25-310 µm pillar height, 14 µm diameter, magnetically reshapeable; 3Brain HD-MEA adjacent) + Tian 2025 Nat Commun hiPSC epicardium mTOR maturation (DOI 10.1038/s41467-025-60934-8, Wiki.js 1745; Torin1 dual mTORC1/2 inhibition drives mature epicardium via YBX3/MAFF TFs) + Aiello & Bagni 2025 biorxiv Rotating Chamber brain organoid CFD (Wiki.js 1746; COMSOL CFD < 20 mPa cavity shear stress, cross-organoid-line morphological CV < 15%) + CelVivo App Note 2026 shear stress ClinoStar vs orbital shaker (Wiki.js 1747; head-to-head comparison across HepG2/C3A + Caco-2 + brain organoid — first vendor App Note deep-read). **All 5 files landed at `04-Literature/Deep-Reads/` root** (non-standard pattern vs the prior per-vendor subfolder discipline). Vendor-anchor mapping: 3 CelVivo-aligned (CelVivo App Note + Aiello [ClinoStar-adjacent] + Ajongbolo mentions ClinoStar) + 1 3Brain-adjacent (Kim EGaIn 3D MEA — 3rd next-gen HD-MEA approach alongside Liu 2026 + 3Brain Accura-3D) + 1 cardiac epicardium (Tian mTOR, no vendor callouts). **Largest single-day LDR burst since the 2026-07-29 Parate / Lee / Hodge cluster**. |
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| 2026-08-12 | **Liang 2026 liver organoid fibrosis platform 4-commit LDR cycle** (commits `e542c977` + `8699a154` + `aacba7aa` + `297f106d`) | **CelVivo (ClinoStar rating 5 + ClinoReactor rating 5)** | Liang Y et al. (2026) A robust mouse liver organoid platform enables sustained multicellular maturation and fibrosis modeling from a single tissue sample (Sci Rep DOI 10.1038/s41598-026-42990-2, PMID 41857098; Wiki.js Id 1716, NocoDB Id 770; 3 轨道 Hep-Orgs + Cho-Orgs + HSC 同步分离; DAPT+Dex P1-P10 长程稳定成熟 [ALB/PAS/LDL/CYP 跨代保持]; TGFβ 激活 qHSC → aHSC [Acta2/Col1a1 上调]; aHSC 共培养诱导 Hep-Orgs EMT [Snail/Twist/Vimentin↑; ALB/CK8↓; Lgr5/EpCAM↓; Ki67↓] = 体外肝纤维化模型) — page 946 9 项 SOP 重写版 + page 934 修齐 标杆; 7/7 Ollama qwen2.5vl 视觉审核通过; SeaFile 7/7 公网 200 验真. First paper whose `related:` field already names `[[MOC-类器官与3D培养]]` (the 2026-08-10 first MOC) on the day of publication. |
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| 2026-08-10 | **Phase A metadata batch + first MOC** (commits `d97b39ed` + `6b717aef` + `3b929c2f`) | (process discipline) | 6 deep-reads received the 6-field frontmatter (doi/journal/year/volume/pages/authors/pmid); first MOC `MOC-类器官与3D培养.md` (95 lines, 沙牛《AI 时代的 Obsidian 公开课》课时 1 pattern) created at `04-Literature/Deep-Reads/MOCs/`; 7 image alt descriptions added on `wang2024-org-on-chip.md`. No new external evidence. |
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| 2026-08-09 | `10.7150/thno.90492` (Wang 2024) | (4 类共性硬件 — Organoid-on-Chip 综述) | Wang H et al. (2024) Human organoids-on-chips for biomedical research and applications (Theranostics 14(2):788-818, PMID 38169573; 7 图覆盖 7 大主题板块) — Wiki.js ID 1700 (v2 - grp:3 ghost page 累加) |
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| 2026-08-08 | `10.3390/cells15110963` (Fernandez Vallone 2026) | (NAMs adjacent, hiPSC brain organoid) | THSDC chemical evaluation platform using hiPSC brain organoids (Cells, v2 5 张真图 + 双 H1; Wiki.js Id 1698) |
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| 2026-08-08 | `10.3389/fbioe.2026.1854988` (Rosero 2026) | CelVivo + Cellink + FemtoBiomed adjacent | Microbioreactor design Mini Review (Front Bioeng Biotechnol; 6× productivity vs T-flask; 4 applications: CAR-T / mAb / iPSC / organoid) |
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| 2026-08-08 | `10.1038/s41551-026-01620-y` (Liu 2026) | 3Brain (HD-MEA rating 5) + Cellink (microlattice rating 5) | Shape-conformal porous framework for full-coverage neural organoid e-phys — Rogers Lab, Nat Biomed Eng |
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| 2026-08-08 | `10.1016/j.cell.2025.05.041` (Miao 2025 v2) | CelVivo (ClinoStar rating 5) | Co-development mesoderm+endoderm for vascularized lung/gut organoids (Cell v2) |
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| 2026-08-08 | `10.1016/j.stem.2025.12.013` (Sharma 2026) | 3Brain (HD-MEA rating 4) + CelVivo (ClinoStar rating 3) | Vascularized retinal organoid RGC survival (Cell Stem Cell) |
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| 2026-08-06 | `10.1038/s41467-024-44732-2` (Parfitt 2024) | CelVivo + 3Brain adjacent | DJ1 LOF midbrain organoid PD model — α-syn via astrocyte lysosomal degradation (Nat Commun, untracked) |
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| 2026-07-29 | Organoids for disease modeling and treatment 2026 综述 (PMID 41545895, PMC12828948) | review | Exp Hematol Oncol 2026 — 190 项临床试验 + 4 大瓶颈 |
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| 2026-07-28 | `10.1080_17460751.2025.2572177` (Hodge 2025) | Ronawk Bio-Block | MSC longevity 4-week comparison |
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| 2026-07-28 | `10.3389/fvets.2025.1500267` (Lee 2025) | (no vendor) | canine adipose MSC 3D spheroid |
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| 2026-07-28 | `10.1186_s13287-018-1085-9` (Komatsu 2018) | CelVivo + Cellink | Type I collagen + YAP/TAZ |
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| 2026-07-28 | `10.1186_s13287-020-1566-5` (Parate 2020) | (no vendor) | PEMF potentiate MSC paracrine cartilage |
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| 2026-07-27 | `Raji_2026_hMOs` | 3Brain | hMOs dopaminergic + HD-MEA |
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| 2026-07-27 | `Tasevska_2025_HCTZ` | Cellink | SSE-printed HCTZ extended-release |
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| 2026-07-17 | `260528_CS_vs_OS` appnote | CelVivo | ClinoStar vs Orbital Shaker shear stress |
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| 2026-07-17 | `111_Planimetry` appnote | CelVivo | FIJI planimetry on ClinoReactor |
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| 2026-07-05 | `10.1002_btpr.2528` | CelVivo | Spheroid dissociation device |
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| 2026-06-25 | `10.1016_j.stemcr.2025.102646` | CelVivo | High-throughput microfluidic organoid-on-a-chip |
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| 2026-06-24 | `10.1021_acsomega.5c02682` | 3Brain | rotating human melanoma cell culture |
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| 2026-06-24 | `10.1016_j.xpro.2025.103923` | CelVivo | Lung Tumoroids protocol |
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| 2026-06-23 | `10.1002_jbm4.10792` | CelVivo | microfluidic organoid-on-a-chip (v2-munir2023) |
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| 2026-06-23 | `10.3390_cells11203216` | CelVivo | NAFLD mapping proteome/lipidome |
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By vendor (30-day mtime):
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| Vendor | Most recent | 2026-08-08 / 2026-08-10 / 2026-08-12 / 2026-08-16 additions |
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| --- | --- | --- |
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| CelVivo | 2026-08-12 (Liang 2026 — ClinoStar rating 5 + ClinoReactor rating 5) | +Liang 2026 (P1-P10 长程成熟 + 单组织 3 轨道分通道灌流 + TGFβ 时间程序精确切换 — liver organoid fibrosis platform), +Miao 2025 v2 (ClinoStar co-differentiation), +Sharma 2026 (ClinoStar rating 3 adjacent), +Liu 2026 (ClinoStar rating 4 adjacent), +Quintard 2024 (CelVivo ClinoStar rating 3 — upstream workflow step: BVO day 0-15 needs rotating-wall suspension culture), +Guo 2026 (CelVivo ClinoStar rating 4 — clinical-translation IRB compliance for 三甲医院 客户) |
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| 3Brain | 2026-08-08 (Liu 2026 — HD-MEA rating 5) | +Liu 2026 (shape-conformal framework, next-gen HD-MEA), +Sharma 2026 (HD-MEA rating 4 adjacent), +Shin 2024 (Phase A frontmatter hygiene on existing note), **−3Brain reference removed from Quintard 2024 -v4 (per commit `4073abf4` — "精读 Quintard 2024 -v4 (转发语标题/落款加粗/删3Brain)" was the explicit SOP rule "硬门槛合规修正" cleanup; Quintard is vendor-adjacent CelVivo/Mimetas/Emulate rather than 3Brain territory)** |
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| Cellink | 2026-07-27 (Tasevska 2025) | +Liu 2026 (microlattice fabrication rating 5 adjacent), **+Quintard 2024 (microfluidic organ-on-chip adjacent, no direct Cellink rating — but the platform architecture is a candidate cross-sell with Cellink BIO X for vascularized scaffold fabrication)** |
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| Adjacent (no vendor) | 2026-08-08 (Sharma 2026 retinal vascularization) | +Sharma 2026 (retinal organoid application domain) |
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| (Process discipline) | 2026-08-10 (Phase A batch + first MOC) | +6 deep-reads received 6-field frontmatter; +first MOC `MOC-类器官与3D培养.md` created; +7 image alt descriptions on Wang 2024 — no new external evidence |
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| (Subfolder expansion, uncommitted) | 2026-08-13 (new `Review/` subfolder) | +1 untracked file `Review/zhou2023_computer_vision_microfluidics.md` (first review-type subfolder — review papers stream separately from original research) |
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| (Customer-facing template, uncommitted) | 2026-08-16 (new `templates/` subfolder + IRB application checklist v1.0) | +1 untracked file `templates/类器官IRB申请清单.md` 180 lines (Guo 2026 ethics deep-read → IRB checklist template; 7 mandatory points + 5 customer Q&A + China vs International flow + 10 attachments + 7 citations; Robin's first customer-facing template produced from a single deep-read; will route into CelVivo industrial-customers program once committed) |
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| (Commercial quote PDF, untracked) | 2026-08-17 (new `celvivo_commercial/` subfolder) | +1 untracked file `celvivo_commercial/1331651_20260630_131201.pdf` (6-30 quote PDF migrated into a new folder; companion to the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree) |
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The pipeline is **vendor-balanced** — CelVivo, 3Brain, Cellink each have a recent deep read, and the 2026-08-08 flywheel-sync adds **3 papers spanning all 3 primary vendors + the retinal organoid application domain** (Sharma), all 3 rated 4-5 on at least one vendor's product line. The 2026-08-10 cluster is **process discipline** (Phase A metadata batch + first MOC creation + Wang 2024 alt-description sample), not new external evidence — the 6 deep-reads already existed on `main`; the 3 commits only normalize their metadata and add a knowledge-graph index layer. The 2026-08-12 cluster adds **net-new external evidence**: Liang 2026 Sci Rep liver organoid fibrosis platform (4-commit LDR cycle on a single paper, CelVivo ClinoStar ⭐⭐⭐⭐ + ClinoReactor ⭐⭐⭐⭐); this is the **first paper on `main` whose `related:` field already names `[[MOC-类器官与3D培养]]` on the day of publication**, confirming the MOC pattern is in active use on real deep-reads (vs the prior 2026-08-10 "MOC `related:` lists future MOCs" framing which was only prospective). The **first entry in the new NocoDB table `Robin_Picked_Papers`** is Liu 2026 (created 2026-08-08 per Robin instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage). The **first MOC** `MOC-类器官与3D培养.md` is the start of a Map-of-Content layer Robin appears to be building (the MOC's own `related:` already names `[[MOC-3Brain-HD-MEA]]` as the next planned MOC). The 2026-08-13 cluster (no vault commits, 1 new untracked file) **adds a new `Review/` subfolder to the deep-read tree** — Robin appears to be expanding the folder taxonomy to separate review-type papers from original-research papers; whether this is a one-off subfolder or the start of a recurring folder pattern is a watchlist item for the next git-repo fetch. **The 2026-08-16 cluster (Quintard 2024 + Guo 2026) is the largest single-window vault delta since the 2026-07-28 / 2026-07-29 cluster** — 7 new vault commits spanning 2 new paper deep-reads, 2 new untracked working-tree directories, and 1 customer-facing sales-ammunition template derived from a single deep-read. The Quintard 2024 microfluidic / organ-on-chip platform (CelVivo ClinoStar upstream + Mimetas OrganoPlate direct competitor + Emulate Organ-Chip) extends Robin's vendor mapping into the organ-on-chip product lane that his portfolio doesn't currently cover; the Guo 2026 organoid ethics systematic review (7 mandatory points + 5 jurisdiction comparison) introduces the IRB / ethics domain to Robin's deep-read set and spawned `templates/类器官IRB申请清单.md` (180 lines, Robin's first customer-facing template) as the canonical "Robin 培训客户 IRB 申请" core material. The new `templates/` + `celvivo_commercial/` directories appear alongside the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree — Robin may be formalizing customer-facing deliverables (checklists / templates / sales scripts) as a separate vault subtree. The `Review/zhou2023_computer_vision_microfluidics.md` carry-forward untracked file is still-uncommitted at this fetch (now 4 days past the 2026-08-13 first observation); the watchlist trigger is if it remains uncommitted at the next fetch.
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## Sales ammunition pipeline
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Robin maintains a working sales library that consumes LDR output and routes into the `/sources/sales-ammunition.md` page:
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- **Pricing + SKUs:** Demo kit `10005-6` lists at €300 (Global Distributor Price, with special discount); `10004-12` ClinoReactor 12-pack; `30003` ClinoStar; `SP5D-24W` low-adherence plate. Pricing source: `Exhibit 1_Celvivo Price Book 2026_Global_Distributior.xlsx` (RAGFlow KB full-text).
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- **8 ClinoReactor Protocols:** 003 (prepare) / 004 (media change) / 006 (gardening) / 009 (plate config) / 010 (ClinoReactor prepare) / 012 (rotation speed — core selling point) / 014 (alginate embed) / 015 (VitroGel embed).
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- **5 application notes by organ:** HepG2/C3A liver / FTC-133 thyroid / NCI-H69V SCLC / TNBC / ClinoStar vs Orbital Shaker.
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- **5 brand / whitepapers:** Brochure 2026 update_for print + _online version / Cancer White Paper 2026 / 2026.04.01.715868v1 (biorxiv 2026 preprint) / ijms-24-13506-v2.
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- **8 commercial docs:** Exhibit 1 Price Book / Exhibit 3 SuperUser certification / Huibai demo discount agreement / 惠百 PO 盖章版 / Celvivo Distribution Agreement 2026 Huibai Bio / 1331651_20260630_131201 (6-30 quote) / Packing Slip Ordre 726_1 / Packing Slip Ordre 726_2.
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Cross-link to the canonical synthesis: [`/sources/sales-ammunition.md`](/sources/sales-ammunition.md).
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**2026-08-16 addition — `templates/类器官IRB申请清单.md` v1.0** (180 lines, Robin 8-16 实战沉淀, **untracked**; derived from Guo 2026 Front Cell Dev Biol IRB / ethics systematic review — Wiki.js ID 1724, NocoDB Id 3298). The IRB application checklist is **Robin 第一份 customer-facing template produced from a single deep-read** and consists of: (a) **7 强制要点** [样本来源合法性 + 捐赠者知情同意 + 数据隐私与去标识化 + 共培养产物主体性评估 + 动物福利 3R + 跨境监管合规 + 长期保存与终止使用]; (b) **5 customer Q&A** [类器官研究是否要 IRB 申请 / 类器官共培养产品怎么申请 IRB / 类器官跨境研究怎么报 / 3R 原则怎么写 / 类器官 + 免疫细胞共培养 = CAR-T 体外培养, 算不算新生物体]; (c) **China vs International flow comparison table** [中国 2023 新规 vs 美国 Common Rule vs 欧盟 GDPR]; (d) **10 申请附件清单** [IRB 申请表 + 知情同意书 + 研究方案 + DMP + 样本采集机构 IRB 批件 + ...]; (e) **7 引用** [Guo 2026 + ISSCR 2021 + OHRP 2016 + GDPR + 中国 2023 + 中国 2019 + Cambridge 2020]. **Vendor relevance**: CelVivo ClinoStar ⭐⭐⭐⭐ (the 7 mandatory points directly apply to ClinoStar customer IRB submissions; **Robin 推广 ClinoStar 给三甲医院时, 可附带本框架作为增值**). Tracks as `/commitments.md` `guo-2026-organoid-irb-checklist-rollout` (Owner: me; fold IRB application checklist into CelVivo industrial-customers program + Robin customer-training core material; commit `templates/类器官IRB申请清单.md` and add a synthesis page at `/sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md`).
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## Sales training cluster (working-tree additions)
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|
||
Per `/sources/git-repo.md` §"Notable entities", `06-Sales/Content/Training-Materials/` contains the following working-tree additions not yet on `main`:
|
||
|
||
- `CelVivo_销售培训_PPT_v9_给销售看版.pptx` (3.9 MB, 06-26 14:13) — latest PPT
|
||
- `CelVivo_Robin老师逐字稿_v6_深度版_20260626.md` (63 KB, 06-26 13:45) — latest verbatim script
|
||
- `CelVivo_销售培训_讲义_v2_20260626.md` (13 KB, 06-26 12:14) — latest handout
|
||
- `Robin稿生成通字稿` family (v3–v6) and `CelVivo赋能培训` family (v1–v9, depth-flavored edits)
|
||
- `销售基础话术包` pair
|
||
|
||
The version progression is `基础 → 5大管线 → 深度版 → 终稿修正 → 销量仅看` — the cluster is iterated in place, not committed. See [`/sources/vault-mtime-snapshot-2026-07-16.md`](/sources/vault-mtime-snapshot-2026-07-16.md) for the latest mtime census (CelVivo_销售培训_PPT_v9 = 2026-06-26 14:13).
|
||
|
||
## China distributor map (259 dealers across 7 regions — 2026-08-07 baseline)
|
||
|
||
From [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) (Hermes整理, 2026-08-07; **replaces 2026-07-24 baseline of 261 dealers**):
|
||
|
||
| Region | 8-07 count | 7-24 count | Δ | Share | Main city |
|
||
| --- | ---: | ---: | ---: | ---: | --- |
|
||
| 华北 | 72 | 74 | -2 | 27.8% | 北京 (54) |
|
||
| 华东 | 68 | 68 | 0 | 26.3% | 上海 (53) |
|
||
| 华南 | 62 | 62 | 0 | 23.9% | 广州 (44) |
|
||
| 山东 | 25 | 25 | 0 | 9.7% | 济南 (22) |
|
||
| 湖北 | 19 | 19 | 0 | 7.3% | 武汉 (12) |
|
||
| 西北 | 6 | 6 | 0 | 2.3% | 西安 (6) |
|
||
| 西南 | 7 | 7 | 0 | 2.7% | 重庆 (3) |
|
||
| **TOTAL** | **259** | **261** | **-2** | 100% | — |
|
||
|
||
Brand keyword map (top 20 by 全国 count): BI 19 / Thermo 19 / Bio-Rad 11 / 赛默飞 8 / 安捷伦 7 / 蔡司 6 / Cytiva 6 / 伯乐 6 / 徕卡 6 / 赛多利斯 5 / Eppendorf 5 / Leica 5 / Beckman 4 / Merck 4 / Waters 4 / Azure 3 / Bruker 3 / Oxford Nanopore 3 / Agilent 3 / Sartorius 3.
|
||
|
||
**8-07 独有产品-代理映射 (from `_known_associations.md`):**
|
||
|
||
| 产品线 | 关联代理 / 中间方 | 关联客户 / 商机 |
|
||
|---|---|---|
|
||
| CelVivo (ClinoStar) | **济南成全生物科技 (曹沛起)** — 华北 + 山东 跨区重复 | 董慧群 (CelVivo 技术同事) — 8-07 hook 4 候选 |
|
||
| FemtoBiomed (CellShot / PROLIVA) | **9X Bio (汇佰生物)** — 中间方 (0 hit in 259 dealer 表) | TriArm Therapeutics (翁靖傑 上海 CGT/CAR-T, 128 万 Phase1 / 8-10 至 8-14 现场 demo) |
|
||
| 3Brain (HD-MEA) | 0 家代理命中 | 11+ end-customer dossiers (需要补 direct agent or sell direct) |
|
||
| Cellink (BIO X) | 0 家代理命中 | (待补) |
|
||
|
||
**Data gap (regional filling rate):** 华东 营收 0/68 / 湖北 营收 0/19 / 华南 销售人数 0/62 — needs补 before next field visit. Documented at [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) §关键数据缺口.
|
||
|
||
**4-vendor break-out is partially resolved:** the 2026-08-07 `_known_associations.md` index identifies CelVivo → 济南成全 + FemtoBiomed → 9X Bio; 3Brain / Cellink direct agents are still 0 (open-question `distributors-3brain-cellink-zero-coverage`).
|
||
|
||
## CRM — active distributor profiles
|
||
|
||
From [`/sources/agents.md`](/sources/agents.md) (last sync 2026-07-28; 2026-08-07 `_known_associations.md` partial resolution):
|
||
|
||
| 姓名 | 角色 | 代理商品牌 | 主推产品 | 首次记录 | 状态 | Vault 路径 |
|
||
| --- | --- | --- | --- | --- | --- | --- |
|
||
| 董慧群 | 代理商技术同事 | 待补 | CelVivo (ClinoStar / ClinoReactor) | 2026-07-28 | active | `02-Clients/Agents/董慧群.md` |
|
||
|
||
This is the only profile currently in the agents bucket. Robin was told about 董慧群 via WeChat DM on 2026-07-28; her role is to help push CelVivo products at the technical / demo / selection stage. Most fields are 待补 (agency name, region, phone, WeChat, customers, opportunities) — this is the only active open question in `/open-questions.md` (see `agent-dong-huiqun-celvivo`).
|
||
|
||
**2026-08-07 partial resolution (Hermes hook 4):** 4 个经销商管理 Hook 升级 (`02-Clients/Agents/_known_associations.md` commit `4b237a82`) identifies **济南成全生物科技有限公司 (曹沛起)** as the only CelVivo ClinoStar-listed agent in the 259-dealer China map (华北 + 山东 跨区重复登记). Whether 董慧群 is 济南成全的技术同事 or another dealer is still unverified — tracked as commitment `dong-huiqun-ji-nan-chengquan-link` in `/commitments.md`. The same hook 4 file maps FemtoBiomed CellShot → 9X Bio (汇佰生物) → TriArm Therapeutics (翁靖傑 上海 CGT/CAR-T, 128 万 Phase1 / 8-10 至 8-14 现场 demo), and 3Brain / Cellink / FemtoBiomed direct agents → 0 in the 259 baseline (open-question `distributors-3brain-cellink-zero-coverage`).
|
||
|
||
**Privacy rule (Robin 7-28):** `/sources/agents.md` and `/sources/distributors-china-2026.md` contain only base identity (name / role / vendor / region); sensitive fields (phone / WeChat / email / end-customer list / opportunity value) live only in the private Obsidian vault. The 2026-08-07 `_known_associations.md` index adds the **product-line → agent → end-customer → opportunity** mapping chain — but does not break the privacy rule because sensitive fields remain in the private vault files.
|
||
|
||
## End-customer dossier set
|
||
|
||
11+ dossiers under `03-Resources/End-Customers/` covering 3Brain HD-MEA accounts at: 神经所 (上海), 北京大学, 北京天坛医院, 浙大一附院, 中科院昆明动物所, 西南医科大学, 贵州医科大学, plus TCM accounts at 云南中医药大学 and 天津创新中药. Dossier content lives in the private vault — only the vault paths are surfaced to the wiki. Documented at [`/sources/git-repo.md`](/sources/git-repo.md) §Notable entities.
|
||
|
||
## CelVivo industrial-customers program (China commercial)
|
||
|
||
A dedicated subfolder under `05-Documents/Products/Celvivo/Industrial-Customers/` holds:
|
||
|
||
- `CelVivo_中国工业客户开发研究报告` (v1 + v2)
|
||
- `客户管线定位_1页图`
|
||
- `工业客户开发手册-v3`
|
||
|
||
This is a self-contained CelVivo China commercial effort. The latest mtime census (2026-07-16 snapshot) shows `CelVivo_中国工业客户开发研究报告_20260626_v2.md` as the most-recent file (18 KB, 06-26 11:52). Documented at [`/sources/git-repo.md`](/sources/git-repo.md) §Notable entities.
|
||
|
||
**2026-08-17 working-tree addition — `celvivo_commercial/1331651_20260630_131201.pdf`** (56 KB, 2026-06-30 quote PDF migrated into a new folder; **untracked**) — companion to the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree. The new folder name signals Robin may be consolidating "Celvivo commercial" documents into a separate vault subtree rather than continuing to nest them under `05-Documents/Products/Celvivo/Industrial-Customers/` (which is the prior convention). If the convention holds, future CelVivo commercial PDFs / quotes / pricing tables will land in `celvivo_commercial/` instead of `05-Documents/Products/Celvivo/Industrial-Customers/`; if it doesn't hold, it's a one-off folder for the 6-30 quote. Watchlist trigger: if a second PDF or commercial doc lands in `celvivo_commercial/` by the next git-repo fetch, the convention change is real; if it stays single-entry, it's a one-off.
|
||
|
||
## Work-rhythm snapshot (2026-07-16)
|
||
|
||
From [`/sources/vault-mtime-snapshot-2026-07-16.md`](/sources/vault-mtime-snapshot-2026-07-16.md) (last full mtime census):
|
||
|
||
```
|
||
2026-07-05 CelVivo 文献精读最后一次 (1 篇)
|
||
2026-06-26 销售培训物料最后一次更新 (v9 PPT + 逐字稿)
|
||
2026-06-18 memory/ 最后一次 daily report
|
||
2026-06-09 vault commit 最后一次
|
||
2026-06-06 CelVivo protocol 系列入库最后一次
|
||
2026-06-04 weekly report 最后一次
|
||
```
|
||
|
||
**Conclusion (snapshot date):** Past 3 weeks (post 2026-07-05) had 0 CelVivo activity. This is **real state**, not an OpenWiki gap. The snapshot recommends Robin write a `memory/2026-07-16-*.md` daily report to capture the gap. This also means the OpenWiki cron `vault-mtime-snapshot` connector is the canonical work-rhythm evidence — it complements the git-repo connector (commit history) and NocoDB (last-touched metadata).
|
||
|
||
## Cross-vendor route map
|
||
|
||
Each research output eventually lands in one of the vendor synthesis themes:
|
||
|
||
| Research artifact | Primary route | Secondary |
|
||
| --- | --- | --- |
|
||
| CelVivo deep reads + sales ammunition | [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) | CelVivo industrial-customers program → `/commitments.md` |
|
||
| 3Brain deep reads + end-customer dossiers | [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) | 3Brain conference positioning → `/commitments.md` `3brain-coreplate-2026-conference-positioning` |
|
||
| Cellink deep reads + BIO X customer evidence | [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md) | New Lumen X release → `/commitments.md` `cellink-volumetric-lumen-x-release` |
|
||
| Femtobiomed deep reads + CellShot-TriArm demo plans | (theme gap — Femtobiomed has no synthesis theme yet) | `01-Active-Sales/` plans → `/commitments.md` |
|
||
| Adjacent non-vendor (MSC / canine / PEMF / 综述) | `class-organoid-3d-bioprinting` theme row on [`/themes.md`](/themes.md) | — |
|
||
| China regulatory (CDE / Order 818 / CGT) | `/commitments.md` items `china-cde-cell-gene-therapy-rules-2026` / `china-order-no-818-clinical-translation` / `china-cgt-2026-july-developments` | — |
|
||
| Distributor / agent | [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) + [`/sources/agents.md`](/sources/agents.md) + `/open-questions.md` `agent-dong-huiqun-celvivo` | — |
|
||
|
||
## Personal-infra and adjacent work
|
||
|
||
These are source-anchored but not vendor-anchored — they live here for traceability but do **not** earn a `/themes.md` row:
|
||
|
||
- **ITX 24h host build (first observed 2026-07-31; still untracked)** — `03-Resources/ITX-24h-Host/ITX_24h_Host_v18_Config_2026-07-31.md`. Plan: mATX + i5-12400 + DDR4-2666 32G + 板载 Realtek 1Gb + Intel PRO/1000 GT 双网卡 NAS 隔离. Budget ¥2,985.82, 10/11 parts arrived. Status: paused awaiting last #8/#9 cable parts. Tracked as `/commitments.md` `itx-24h-host-build-2026-q3` (Owner: me).
|
||
- **OpenWiki cheat sheet (2026-07-27)** — `OpenWiki速查手册_2026-07-27.md` (vault root, untracked). Companion to [`/sources/OpenWiki速查手册.md`](/sources/OpenWiki速查手册.md) (the wiki copy).
|
||
- **4 vendor + 4 application + 4 agents SOP iterations** — the cluster of training materials under `06-Sales/Content/Training-Materials/` is iterated in place without commits; latest is `CelVivo_销售培训_PPT_v9` (06-26 14:13).
|
||
|
||
## Cross-cutting relationship
|
||
|
||
- **Touched by [`/themes/03-ai-agents.md`](/themes/03-ai-agents.md)** — M3 agent synthesis step (02:00 cron) writes research evidence into the synthesis themes; literature-deep-read SOP is what produces the canonical deep-read pages; sales-ammunition query skill routes ClinoReactor-related questions.
|
||
- **Touched by [`/themes/04-local-llm.md`](/themes/04-local-llm.md)** — RAGFlow KB (Celvivo / 3Brian / Cellink) is the deep retrieval surface behind every vendor deep read; SeaFile is the PDF + figure storage; NocoDB is the metadata catalog; Wiki.js is the public publishing target. The 2026-07-17 desktop service-down incident materially degrades the LDR pipeline.
|
||
- **Output routes into [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) and [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md)** — most of the deep reads and vendor evidence in this theme ends up at the vendor synthesis themes.
|
||
- **Outputs routed into `/commitments.md`** — China regulatory items + vendor-channel verification items + ITX host build + CellShot-TriArm demo plans.
|
||
- **Outputs routed into `/open-questions.md`** — `agent-dong-huiqun-celvivo` is the only currently active entry; it is anchored to `02-Clients/Agents/董慧群.md` and is the kind of "ambiguous people/org relationship" gap the wiki brief calls out.
|
||
|
||
## Backlog for this theme
|
||
|
||
- **Femtobiomed synthesis page** — `Femtobiomed CellShot / CellPick / TriArm` has a vault bucket and a `FemtoBiomed_electroporation` RAGFlow KB (123 docs) but no synthesis theme. Currently routes as adjacent cross-sell into `01` and `02`. Consider promoting to `themes/06-femtobiomed.md` if vendor-channel evidence accrues.
|
||
- **Hodge / Lee / Parate synthesis** — 3 adjacent deep reads added 2026-07-28 are not yet synthesized to `/sources/`. Run LDR Step 8 (NocoDB PATCH + Wiki.js publish + OpenWiki commit) when ready.
|
||
- **Work-rhythm snapshot connector** — currently a one-shot `find -mtime` shell command (see `/sources/vault-mtime-snapshot-2026-07-16.md` header). Promote to a weekly cron + auto-write to `/sources/vault-mtime-snapshot-weekly.md` so the work-rhythm signal is durable, not single-snapshot.
|
||
- **End-customer dossier cross-agent page** — 11+ dossiers live in private vault; consider adding a redacted `[name, focus, vendor, region, vault-path]` table to `/sources/agents.md` parallel to the distributor profile pattern. Robin decision pending.
|
||
- **CellShot-TriArm demo plan v3** — current demo plans are v1 (2026-07-21) and v2 (2026-07-22, 邮件用 + 老师版 two-commit split). No v3 yet; the v2 plan lives in vault commit history `1787702c` / `62877d1f` / `62d09c5f`. Promote to `/commitments.md` when v3 lands.
|
||
- **MOC pattern extension (2026-08-10 onward)** — Robin created the first MOC
|
||
(`04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md`, commit `6b717aef`,
|
||
95 lines, 沙牛《AI 时代的 Obsidian 公开课》课时 1 pattern); the MOC's
|
||
`related:` list already names the next planned MOC —
|
||
`[[MOC-3Brain-HD-MEA]]` — plus
|
||
`[[02-Clients/Agents/_known_associations]]` and
|
||
`[[02-Active-Deals/CellShot-TriArm-Demo-计划-v2-老师版-2026-07-20]]`.
|
||
Track on the next git-repo fetch whether the MOC pattern extends to
|
||
MOC-3Brain-HD-MEA, MOC-Cellink-BIO-X, MOC-Femtobiomed-CellShot, etc.
|
||
If ≥3 MOCs land, consider adding a `/themes.md` annex row on
|
||
`vault-knowledge-architecture` and a `/sources/` page that maps the
|
||
MOC graph (file → topics → cross-refs → flywheel cron hooks).
|
||
- **Phase A frontmatter batch rollout (2026-08-10 onward)** — Phase A
|
||
standardized 6 deep-read notes with the 6-field frontmatter
|
||
(doi / journal / year / volume / pages / authors / pmid); ~1,196
|
||
deep-read notes remain without the new fields. Track rollout
|
||
cadence — if Robin completes the batch on a fixed cadence (e.g.
|
||
daily/weekly cron), document the cadence here so future agents can
|
||
answer "what is the frontmatter hygiene status of the vault?".
|
||
|
||
## What to read next
|
||
|
||
| Question | Go to |
|
||
| --- | --- |
|
||
| What is the canonical LDR master template? | [`/sources/ldr-report-template.md`](/sources/ldr-report-template.md) |
|
||
| What did the 7-27 SOP-vs-implementation pass reveal? | [`/sources/2026-07-27-4-27-sop-vs-implementation.md`](/sources/2026-07-27-4-27-sop-vs-implementation.md) |
|
||
| What is the current Obsidian vault manifest? | [`/sources/git-repo.md`](/sources/git-repo.md) |
|
||
| What is the 30-day literature deep-read digest? | [`/sources/literature.md`](/sources/literature.md) |
|
||
| What is in the CelVivo sales ammunition kit? | [`/sources/sales-ammunition.md`](/sources/sales-ammunition.md) |
|
||
| What is the China 261-dealer map? | [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) |
|
||
| Who is Robin actively working with? | [`/sources/agents.md`](/sources/agents.md) |
|
||
| What is the work-rhythm cadence? | [`/sources/vault-mtime-snapshot-2026-07-16.md`](/sources/vault-mtime-snapshot-2026-07-16.md) |
|
||
| What does the CelVivo 2026 whitepaper say? | [`/sources/literature-celvivo-brain-whitepaper-2026.md`](/sources/literature-celvivo-brain-whitepaper-2026.md) |
|
||
| What does the Bosnjakovic 2025 PAH paper say? | [`/sources/literature-cel-bosnjakovic-2025-pah-deepread.md`](/sources/literature-cel-bosnjakovic-2025-pah-deepread.md) |
|
||
| What is the Raji 2026 hMOs + 3Brain story? | [`/sources/literature-raji-2026-deepread.md`](/sources/literature-raji-2026-deepread.md) |
|
||
| What is the Tasevska 2025 BIO X SSE story? | [`/sources/literature-tasevska-2025-deepread.md`](/sources/literature-tasevska-2025-deepread.md) |
|
||
| How does the agent stack consume this output? | [`/themes/03-ai-agents.md`](/themes/03-ai-agents.md) |
|
||
| How does the local-LLM fleet host this evidence? | [`/themes/04-local-llm.md`](/themes/04-local-llm.md) |
|
||
| Where does CelVivo + 3Brain output land? | [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) |
|
||
| Where does Cellink output land? | [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md) |
|
||
| What does Quintard 2024 say about vascularized organoid chips? | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
|
||
| What does Guo 2026 say about organoid IRB ethics? | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
|
||
| What's the IRB application checklist for organoid research? | `templates/类器官IRB申请清单.md` v1.0 (vault path; untracked) ||th; deep-read synthesis not yet split out to `/sources/`) |
|
||
| What's the IRB application checklist for organoid research? | `templates/类器官IRB申请清单.md` v1.0 (vault path; untracked) ||t path; untracked) || ||) || ||) || ||ethical_review.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
|
||
| What's the IRB application checklist for organoid research? | `templates/类器官IRB申请清单.md` v1.0 (vault path; untracked) ||th; deep-read synthesis not yet split out to `/sources/`) |
|
||
| What's the IRB application checklist for organoid research? | `templates/类器官IRB申请清单.md` v1.0 (vault path; untracked) ||t path; untracked) || ||) || ||) || || |