OpenWiki Bot
72 lines
8.8 KiB
Markdown
72 lines
8.8 KiB
Markdown
---
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type: "Reference"
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title: "Open Questions"
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description: "Active, Answered, and Stale unresolved questions about Robin's memory, recurring routines, people, projects, and wiki quality. Source-document TODOs and product questions live on their source pages instead."
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tags: [open-questions, unresolved, agent-dong-huiqun-celvivo, chengdu-baile-vs-lidesai-for-ou-xianhong, distributors-3brain-cellink-zero-coverage]
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---
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# Open Questions
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Unresolved questions about Robin's memory, recurring routines, people, projects, and wiki quality. Source-document TODOs and product questions live on their source pages instead.
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## Active
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### agent-dong-huiqun-celvivo: which distributor does 董慧群 belong to, and what region / customers / contact info does she cover?
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- Owner: me (Robin)
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- Seen: 2026-07-28
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- Evidence: `02-Clients/Agents/董慧群.md` in the Obsidian vault (frontmatter `type: agent`, role: 代理商技术同事, products: CelVivo ClinoStar / ClinoReactor, status: active, last-contact: 2026-07-28). Manifest entry: `~/.openwiki/connectors/git-repo/raw/2026-07-28T18-07-57-114Z/manifest.json` commit `21491578`. 2026-08-07 partial resolution: `02-Clients/Agents/_known_associations.md` (commit `4b237a82`, Hermes Agent hook 4) identifies **济南成全生物科技有限公司 (曹沛起)** as the only ClinoStar-listed agent in the 259-dealer China map — 华北 + 山东 跨区重复登记. Cross-reference at [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) § "8-07 新增：_known_associations.md 索引".
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- Notes: profile is mostly 待补 (agency company name, region, phone, WeChat, served end-customers, opportunities). Robin was told about 董慧群 via WeChat DM on 2026-07-28 — her role is to help push CelVivo products at the technical / demo / selection stage. The 2026-08-07 `123hook_4` partial-resolution gave a likely candidate (济南成全生物科技有限公司 — same contact 曹沛起 in both 华北表 + 山东表) but the precise link to 董慧群 (and whether she is 济南成全的技术同事, or another dealer) is still unverified. Until confirmed, future agents cannot reason about which CelVivo deals 董慧群 might support or which Chinese pharma R&D / CDMO accounts overlap with her territorial reach. The narrower, still-open question is: **is 董慧群 济南成全生物科技 (曹沛起) 的技术同事, or another CelVivo-aligned agent?**
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### liu-2026-rogers-lab-vs-3brain-relationship: is there any partnership / licensing / competitive pressure between Rogers Lab (Liu 2026) and 3Brain?
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- Owner: me (Robin)
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- Seen: 2026-08-08
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- Evidence: literature flywheel-sync 2026-08-08 — Liu N et al. (2026) Nature Biomedical Engineering, DOI 10.1038/s41551-026-01620-y, Wiki.js Id 1692, SeaFile PDF https://fb.biokingdom.top/f/6da50240729e41bdb369/?dl=1. Deep-read at [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md). Commitment at [`/commitments.md`](/commitments.md) `liu-2026-hd-mea-roadmap-implication`.
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- Notes: Liu 2026 establishes a next-gen shape-conformal porous framework for full-coverage (>90% surface) neural organoid electrophysiology at 3000-8000 channels per organoid (10-50× current 3Brain Accura-3D). Rogers Lab (Northwestern) is a major flexible-electronics / bioelectronics group. Three plausible relationships with 3Brain: (a) **partnership** — Rogers Lab licenses the flexible-electronics framework to 3Brain for productization; (b) **competitive pressure** — Rogers Lab or a spinout company commercializes the framework as a competing HD-MEA product; (c) **academic-only** — Rogers Lab has no commercial intent and 3Brain continues to be the best-in-class commercial HD-MEA. Until this is clarified, Robin cannot advise 3Brain customers on whether to wait for next-gen HD-MEA hardware or buy current Accura-3D now. Future agents reading Liu 2026 should treat the "next-gen direction" framing with caution until the 3Brain roadmap is verified.
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### chengdu-baile-vs-lidesai-for-ou-xianhong: which 成都 dealer should Robin approach first for 西南医科大学心研所 (殴贤红) CelVivo / 3Brain cross-sell?
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- Owner: me (Robin)
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- Seen: 2026-08-07
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- Evidence: `02-Clients/Agents/_known_associations.md` (Obsidian vault, 2026-08-07 commit `4b237a82`) — 候选代理 A: **成都百乐 (杨军)** — 覆盖川渝黔藏 · 1亿/钻石 · 主营 Bio-Rad/Sartorius/Oxford Nanopore/Cytek/Leica; 候选代理 B: **成都立德赛** — 覆盖川渝云贵陕. End-customer: 西南医科大学心血管研究所 (殴贤红, 四川泸州). Cue: Hermes hook 4 recommended "先联系 成都百乐 (钻石级 1亿, 主营匹配度更高)". Cross-reference: [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) § "8-07 新增：_known_associations.md 索引".
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- Notes: Robin needs to pick the first 成都 dealer to approach for the 殴贤红 CelVivo / 3Brain cross-sell. Two candidates identified in the 2026-08-07 `_known_associations.md` sweep: 成都百乐 (1亿/钻石级, 川渝黔藏 + 主营 Bio-Rad/Sartorius/Oxford Nanopore/Cytek/Leica — overlap with FemtoBiomed / 3Brain product line) vs 成都立德赛 (覆盖川渝云贵陕, 主营待查). Hermes hook 4 default recommendation is 成都百乐, but Robin's existing relationship depth with either dealer is unknown. Until Robin makes the call, the cross-sell cannot be initiated.
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### distributors-3brain-cellink-zero-coverage: 259 dealer list shows 0 三Brain / 0 Cellink / 0 FemtoBiomed direct agents — is the channel gap real, or is the 8-04 xlsx missing these brands?
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- Owner: me (Robin)
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- Seen: 2026-08-07
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- Evidence: `02-Clients/Agents/_known_associations.md` (Obsidian vault, 2026-08-07 commit `4b237a82`) — product-line hit summary shows only CelVivo (济南成全) directly; 3Brain / Cellink / FemtoBiomed all 0. FemtoBiomed CellShot is documented as a 9X Bio (汇佰生物) direct intermediate, not in the 259 dealer list. Cross-reference: [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) § "8-07 新增：_known_associations.md 索引".
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- Notes: The 2026-08-07 xlsx-baseline scan found zero dealers in the 259-row list that explicitly carry 3Brain HD-MEA or Cellink BIO X. For 3Brain HD-MEA, where Robin has 11+ end-customer dossiers (神经所 / 北京大学 / 北京天坛 / 浙大一附院 / 中科院昆明 / 西南医大 / 贵州医大 / 云南中医药 / 天津创新中药), this is a striking gap — either (a) the 8-04 xlsx is missing the 3Brain agents, or (b) no Chinese distributor has picked up 3Brain and Robin needs to either find/appoint one or sell direct. Until Robin clarifies, the 3Brain-side commercial strategy (channel vs direct) for the +11 known Chinese end-customers remains unresolved.
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### sharma-2026-retinal-organoid-mea-cross-sell: does the 60-channel MCS MEA route transfer cleanly to 3Brain HD-MEA for vascularized retinal organoid RGC recording?
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- Owner: me (Robin)
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- Seen: 2026-08-08
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- Evidence: literature flywheel-sync 2026-08-08 — Sharma K et al. (2026) Cell Stem Cell 33:253-271.e13, DOI 10.1016/j.stem.5.12.013, PMID 41529691, Wiki.js Id 1678, NocoDB row 700, SeaFile PDF https://fb.biokingdom.top/f/861202f029004d75b456/?dl=1. Deep-read at [`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`](/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md).
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- Notes: Sharma 2026 records vascularized retinal organoid (vRO) W31 ON/OFF/ON-OFF light responses using **60-channel MCS MEA2100-Lite** (not HD-MEA) — 60 channels at 32 kHz, no HD spatial resolution. The RGC fraction (W18: 18.2% vs 1.21% ctrl-RO) and the W31 light responses are clinically meaningful, but the MEA is bottom-surface-only (no 3D spatial resolution). Robin's own flywheel audit flagged product_relevance.rating=4 for 3Brain HD-MEA on the basis that "technical route is transferable" — but the actual technical transfer requires verifying that 3Brain's Accura-3D chip supports opsin + optogenetic + light-response recording at week-31+ retinal organoid maturity (long-duration stability). Without this confirmation, the cross-sell pitch to 3Brain's retinal-organoid accounts is theoretical. Future agents pitching Sharma 2026 to 3Brain prospects should verify the technical route end-to-end before committing.
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## Answered
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## Stale
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