chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-07)

2026-08-07 19:05:11 +08:00
42 changed files with 497 additions and 2738 deletions
@@ -1,5 +1,5 @@
 {
-  "updatedAt": "2026-08-21T18:16:08.658Z",
+  "updatedAt": "2026-08-07T10:43:02.305Z",
  "command": "update",
  "model": "MiniMax-M3",
  "status": "complete",
@@ -1,8 +1,7 @@
 ---
 type: "Reference"
 title: "OpenWiki 现状 + 操作手册 (2026-07-27)"
-description: "Activation status + operations manual for Robin's local OpenWiki knowledge base as of 2026-07-27. Documents 4 active connectors (HN + git-repo + Tavily + RAGFlow) and the per-source sync scripts (HN top+best feeds, Tavily web-search with TAVILY_API_KEY, git-repo Obsidian vault at /home/ldw/workspace, RAGFlow full-text retrieval at 10.10.10.254:9980). Captures the on-disk Gitea commit + push pattern."
+openwiki_generated: true
 tags: [openwiki, operations, manual, activation, 2026-07-27]
 ---
 # OpenWiki 现状 + 操作手册 (2026-07-27)
@@ -1,8 +1,7 @@
 ---
 type: "Reference"
 title: "Commitments"
-description: "Active work tasks, follow-ups, approvals, and scheduled items extracted from sources (web-search, git-repo, literature flywheel-sync, etc.). Personal errands live in /personal-logistics.md instead."
+openwiki_generated: true
 tags: [commitments, work, follow-ups, distributors-2026-08-07-refresh, dong-huiqun-ji-nan-chengquan-link, liang-2026-celvivo-clinostar-positioning, guo-2026-organoid-irb-checklist-rollout]
 ---
 # Commitments
@@ -74,55 +73,6 @@ Concrete work tasks, follow-ups, approvals, and scheduled items extracted from G
 - Status: open
 - Notes: Personal-infra work item (workflow-tooling priority LOW), not vendor-anchored — logged here because it is source-anchored to Robin's actual vault work per the brief's commitments.md rule ("only real Robin commitments"). Plan: mATX + i5-12400 + DDR4-2666 32G + 板载 Realtek 1Gb + Intel PRO/1000 GT (¥2,985.82, 10/11 parts on hand). Two 网卡 VLAN: 192.168.31.100 → 主力机 Win 11 SSH, 10.10.10.254 → 主力 NAS RAGFlow. Post-assembly steps: Ubuntu Server 22.04 LTS install, partition `/` (GM7 512G) + `/data` (mSATA 512G), Docker, dual-NIC 静态 IP, 主力机 SSH key 免密, NAS RAGFlow API 接入, 安装 Hermes Agent, 24h 跑功耗 soak test. The host has no vendor-product overlap; not promoted to `/themes.md` row because that index is reserved for recurring workflow signals.
 ### liu-2026-hd-mea-roadmap-implication: verify with 3Brain whether the Liu 2026 shape-conformal framework is on their product roadmap
 - Owner: me
 - Source: literature flywheel-sync 2026-08-08 — Liu N et al. (2026) Nature Biomedical Engineering, DOI 10.1038/s41551-026-01620-y, Wiki.js Id 1692, NocoDB row 1 in **new table `Robin_Picked_Papers`** (created 2026-08-08, table_id `mbjo0wb56qv1qly`), SeaFile PDF https://fb.biokingdom.top/f/6da50240729e41bdb369/?dl=1. Deep-read synthesis at [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md)
 - Due: unscheduled
 - Status: open
 - Notes: **Highest product-relevance cluster of today's flywheel-sync**: HD-MEA rating 5 (3000-8000 channels vs current 3Brain Accura-3D 4096; >90% surface coverage vs 5-15% bottom-only), 3D bioprinting microlattice rating 5 (Cellink BIONOVA X / Lumen X cannot directly print at this resolution today but the field direction is clear), patient-derived organoid drug screening rating 5 (first long-term high-throughput electrophysiology drug screening platform — weeks-long stable recording + epilepsy + AD disease modeling). Robin should sell 3Brain's current 4096-electrode Accura-3D as the existing best-in-class AND track whether 3Brain has a flexible-electronics / shape-conformal framework on their roadmap. Companion question on `/open-questions.md`: `liu-2026-rogers-lab-vs-3brain-relationship` (is there any partnership / licensing / competitive pressure between Rogers Lab and 3Brain?). Companion commitment to verify with Cellink: `liu-2026-cellink-microlattice-positioning` (whether BIONOVA X or Lumen X can fabricate flexible-electronics-compatible microlattices).
 ### miao-2025-celvivo-clinostar-positioning: fold Miao 2025 vHLPO co-differentiation story into CelVivo ClinoStar sales narrative
 - Owner: me
 - Source: literature flywheel-sync 2026-08-08 — Miao Y et al. (2025) Cell v2, DOI 10.1016/j.cell.2025.05.041, PMID 40592324, Wiki.js Id 1681, NocoDB row 93, SeaFile PDF https://fb.biokingdom.top/f/24704d54a95941449e2e/?dl=1. Deep-read synthesis at [`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`](/sources/literature-miao-2025-cell-vascularization-v2-deepread.md)
 - Due: unscheduled
 - Status: open
 - Notes: **Strongest CelVivo ClinoStar product relevance rating (5) in any of the 3 new flywheel-sync papers** — the vHLPO single 3D EB co-induction (mesoderm+endoderm) protocol depends on 3D EB self-organization in low-shear rotating culture, which is exactly what ClinoStar provides. vHLPO 7% ECs vs traditional HLPO 0% is a clinically-meaningful differentiator that no competing 2D / static culture can match. Sales ammunition: "your lung organoid model is missing 100% of vasculature — ClinoStar co-differentiation gives you 7% ECs vs 0%". Cross-vendor co-marketing: CelVivo ClinoStar (culture) + Cellink BIO X (decellularized lung scaffold) + 3Brain HD-MEA (functional readout on the neural mesenchyme). Robin should fold this into the CelVivo industrial-customers program (existing `CelVivo_中国工业客户开发研究报告` v1 + v2 in vault) and pitch to pediatric-hospital pharma R&D accounts (FOXF1 ACDMPV rare disease).
 ### liang-2026-celvivo-clinostar-positioning: fold Liang 2026 长程成熟 + 体外纤维化模型 story into CelVivo ClinoStar / ClinoReactor sales narrative
 - Owner: me
 - Source: git-repo-1 2026-08-12 (vault commit cluster `e542c977` → `8699a154` → `aacba7aa` → `297f106d`) — Liang Y, Ye Y, Xie H, Lui VCH, Chen Y, Tam PKH. (2026) *Scientific Reports* DOI 10.1038/s41598-026-42990-2, PMID 41857098; Wiki.js Id 1716, NocoDB Id 770; SeaFile PDF https://fb.biokingdom.top/f/9d53cfaaa88a45b49b72/?dl=1 + 7 真图 (Fig1-7); vault path `04-Literature/Deep-Reads/Liver/2026-08-12_Liang_2026_SciRep_liver_organoid_fibrosis_platform.md` (170 lines; 4-commit LDR cycle)
 - Due: unscheduled
 - Status: open
 - Notes: **Parallel CelVivo ClinoStar rating 4 + ClinoReactor rating 4 to the existing `miao-2025-celvivo-clinostar-positioning`** but for **liver organoid (long-term maturation + fibrosis modeling)** rather than lung organoid (vascularization). Single tissue 3-轨道 (Hep-Orgs + Cho-Orgs + HSC) → DAPT (Notch 抑制) + Dexamethasone for **P1-P10 长程稳定成熟** (single DAPT only sustains P5; DAPT+Dex 协同才实现 P10) → TGFβ 5-7 day activation of qHSC → aHSC (Acta2/Col1a1 上调) → aHSC 共培养诱导 Hep-Orgs **EMT (Snail/Twist/Vimentin ↑; ALB/CK8 ↓; Lgr5/EpCAM ↓; Ki67 ↓)** = **体外肝纤维化模型**. Sales ammunition: "你的肝类器官只能短期培养? DAPT+Dex P1-P10 稳定成熟 + 单组织 3 轨道 + 14 天纤维化模型 — ClinoStar + ClinoReactor 一站搞定"; paired with "你的抗纤维化药筛需要 14+ 天 3D 多细胞模型 — ClinoReactor 6 通道一次测 6 药". Cross-vendor co-marketing: **CelVivo ClinoStar (P1-P10 旋转扩增) + CelVivo ClinoReactor (3 轨道分通道灌流 + TGFβ 时间程序精确切换) + 3Brain HD-MEA (肝-神经互作延伸, 胆碱能投射场景)**. Customer entry: (a) 药企临床前 — 抗纤维化药筛 14+ 天 3D 多细胞模型 (traditional 2D 或单细胞模型失真); (b) 临床肝活检中心 — 1-2 mg 组织 → 3 轨道 → 3 周内药敏测试 (患者来源 anti-fibrosis drug sensitivity); (c) 学术 PI — 2D 静态分化效率低 → 3D 旋转培养效率提升 2-3 倍. Robin should fold this into the CelVivo industrial-customers program (existing `CelVivo_中国工业客户开发研究报告` v1 + v2 in vault) alongside the Miao 2025 vHLPO entry — these two papers together give a liver + lung CelVivo ClinoStar sales narrative with no 3D-bioprinting vendor dependency. The paper's `related:` field already names `[[MOC-类器官与3D培养]]` (the 2026-08-10 first MOC) — confirms the MOC pattern is in active use on real deep-reads on the day of publication.
 ### robin-picked-papers-nocodb-table: capture the structural change — new NocoDB table for Robin-handpicked papers
 - Owner: me
 - Source: literature flywheel-sync 2026-08-08 — Liu 2026 is the **first entry** in the new NocoDB table `Robin_Picked_Papers` (table_id `mbjo0wb56qv1qly`), created 2026-08-08 per Robin instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage. The table is separate from the existing `Organoid_Literature` table.
 - Due: unscheduled
 - Status: open
 - Notes: The new table has 9 fields: Title, DOI, Journal, Year, Authors, Source, wiki_url, pdf_url, deep_read_summary. Future handpicked papers should land in this table rather than in `Organoid_Literature` (which is PubMed-triage-driven). Verify with Robin: (a) what is the workflow for capturing a handpicked paper — manual PDF drop to `/home/ldw/.hermes/cache/documents/` and then trigger the LDR pipeline; (b) should the LDR pipeline auto-route by signal (PubMed triage vs handpicked), or does Robin always provide the routing signal.
 ### dong-huiqun-ji-nan-chengquan-link: confirm whether 董慧群 is a 济南成全生物科技 技术同事, and route 卸慧群档案 accordingly
 - Owner: me
 - Source: git-repo 2026-08-08 — `02-Clients/Agents/_known_associations.md` (commit `4b237a82`, Hermes Agent 2026-08-07 hook 4) maps 济南成全生物科技有限公司 (曹沛起) as the **only CelVivo ClinoStar-listed agent** in the 259-dealer China map (华北 + 山东 跨区重复登记). `02-Clients/Agents/董慧群.md` (2026-07-28 commit `21491578`) lists 董慧群 as CelVivo 产品技术同事 with `agency: 待补`.
 - Due: unscheduled
 - Status: open
 - Notes: The 2026-08-07 hook 4 partial-resolution gave a likely candidate (济南成全生物科技 曹沛起 company) but the precise link to 董慧群 (and whether she is 济南成全的技术同事, or another dealer) is still unverified. Action: Robin to verify with 董慧群 directly via WeChat / 微信 (current open-question [`/open-questions.md`](/open-questions.md) `agent-dong-huiqun-celvivo`). Once confirmed: update `02-Clients/Agents/董慧群.md` frontmatter `agency` field, and update [`/sources/agents.md`](/sources/agents.md) "代理商品牌" column from "待补" to "济南成全生物科技 (曹沛起)". Until this is done, 董慧群's role in the 济南成全 book of business is unconfirmed.
 ### distributors-2026-08-07-refresh: 落地 2026-08-07 全国经销商地图到 wiki + 跨工具
 - Owner: me
 - Source: git-repo 2026-08-08 — Obsidian vault `02-Clients/Agents/全国经销商地图-2026-0807.md` + 7 区域分文件 (8-07 baseline, 259 dealers across 7 regions, net change -2 from 2026-07-24 baseline). Vault raw survives 2026-08-08 fetch as untracked files (commit `4b237a82` Lin Yongli "4 个经销商管理 Hook 升级").
 - Due: unscheduled
 - Status: open
 - Notes: 8-07 baseline differs from 7-24 baseline in: (a) total 261 → 259 (华北 74 → 72); (b) 济南成全生物科技有限公司 (曹沛起) cross-region registration (华北 + 山东); (c) new `_known_associations.md` index maps CelVivo → 济南成全 / FemtoBiomed → 9X Bio → TriArm / 3Brain + Cellink → 0. Cross-reference: [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) has been updated to the 8-07 baseline + new associations table; [`/sources/agents.md`](/sources/agents.md) still needs the 董慧群 → 济南成全 link; [`/commitments.md`](/commitments.md) has follow-up for 成都百乐 vs 成都立德赛 decision (open-question `chengdu-baile-vs-lidesai-for-ou-xianhong`). End-customer coverage for 3Brain / Cellink / FemtoBiomed still 0 in the 259 baseline — see open-question `distributors-3brain-cellink-zero-coverage`.
 ### guo-2026-organoid-irb-checklist-rollout: commit IRB application checklist template + add Guo 2026 deep-read synthesis page + fold into CelVivo industrial-customers program
 - Owner: me
 - Source: git-repo-1 2026-08-17 — vault commit cluster `2e6f5989` → `00f824f2` → `a4fa5a32` (Guo Z & Zhang N 2026 Front Cell Dev Biol organoid IRB / ethics systematic review, Wiki.js ID 1724, NocoDB Id 3298, DOI 10.3389/fcell.2026.1721946) + new untracked `templates/类器官IRB申请清单.md` v1.0 (180 lines, Robin 8-16 实战沉淀, derived from the Guo 2026 paper)
 - Due: unscheduled
 - Status: open
 - Notes: **First customer-facing template produced from a single deep-read** in Robin's vault — the IRB application checklist is the canonical "Robin 培训客户 IRB 申请" core material for class A tertiary hospitals running organoid IRB submissions. The 7 mandatory points + 5 customer Q&A + China vs International flow table + 10 attachments + 7 citations map directly to the CelVivo ClinoStar clinical-translation sales narrative (Guo 2026 lists CelVivo ClinoStar ⭐⭐⭐⭐ for IRB compliance ammunition). **Three follow-ups needed**: (a) **commit** `templates/类器官IRB申请清单.md` to `main` (currently untracked); (b) add a wiki-side deep-read synthesis page at `/sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md` mirroring the pattern at `/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`; (c) fold the IRB checklist into the existing `05-Documents/Products/Celvivo/Industrial-Customers/` CelVivo commercial docs subtree (or, if the `templates/` folder convention holds, fold it into the new `templates/` vault subtree instead — see Robin decision). Companion commitment to fold into Chinese customer IRB conversations: the checklist covers China《人类遗传资源管理条例》+ 《涉及人的生命科学和医学研究伦理审查办法》2023 — directly applicable to the next Class A tertiary hospital Robin visits for CelVivo or 3Brain training.
 <!--
 Structure for new entries:
@@ -4,16 +4,15 @@ okf_version: "0.1"
 # Files
- [Commitments](commitments.md) - Active work tasks, follow-ups, approvals, and scheduled items extracted from sources (web-search, git-repo, literature flywheel-sync, etc.). Personal errands live in /personal-logistics.md instead.
+- [Commitments](commitments.md)
- [2026-07-16 工具链打通战报](memory-2026-07-16-tools-final.md) - After-action report on Robin's 2026-07-16 end-to-end toolchain integration: OpenWiki + Gitea + NocoDB + RAGFlow + Wiki.js + MiniMax code all wired together and working in production. Snapshot of the pre-flywheel-sync state — pre-dates the 2026-07-26 HN + Tavily launches and the 2026-07-29 Tavily cluster / 2026-08-08 literature flywheel-sync milestones.
+- [2026-07-16 工具链打通战报](memory-2026-07-16-tools-final.md)
- [Open Questions](open-questions.md) - Active, Answered, and Stale unresolved questions about Robin's memory, recurring routines, people, projects, and wiki quality. Source-document TODOs and product questions live on their source pages instead.
+- [Open Questions](open-questions.md)
- [Personal Logistics](personal-logistics.md) - Personal errands, appointments, pickups, travel, household/life-admin deadlines, and other non-work logistics. Work commitments live in /commitments.md.
+- [Personal Logistics](personal-logistics.md)
 - [Robin's Local Knowledge Base](quickstart.md) - OpenWiki entrypoint and orientation — Robin's personal knowledge base with 5 synthesis themes (organoid equipment, bioprinting, AI agents, local LLM, personal research), navigation map, current connector status, and backlog.
- [OpenWiki 现状 + 操作手册 (2026-07-27)](README-ACTIVATION.md) - Activation status + operations manual for Robin's local OpenWiki knowledge base as of 2026-07-27. Documents 4 active connectors (HN + git-repo + Tavily + RAGFlow) and the per-source sync scripts (HN top+best feeds, Tavily web-search with TAVILY_API_KEY, git-repo Obsidian vault at /home/ldw/workspace, RAGFlow full-text retrieval at 10.10.10.254:9980). Captures the on-disk Gitea commit + push pattern.
+- [OpenWiki 现状 + 操作手册 (2026-07-27)](README-ACTIVATION.md)
- [Themes](themes.md) - Recurring topics, signals, and trends observed across Robin's sources. Index of theme rows with confidence labels and source citations; details live on the linked source and synthesis pages.
+- [Themes](themes.md)
 # Directories
 - [large_tool_results](large_tool_results/)
 - [sources](sources/)
 - [themes](themes/)
@@ -1,8 +1,7 @@
 ---
 type: "Reference"
 title: "2026-07-16 工具链打通战报"
-description: "After-action report on Robin's 2026-07-16 end-to-end toolchain integration: OpenWiki + Gitea + NocoDB + RAGFlow + Wiki.js + MiniMax code all wired together and working in production. Snapshot of the pre-flywheel-sync state — pre-dates the 2026-07-26 HN + Tavily launches and the 2026-07-29 Tavily cluster / 2026-08-08 literature flywheel-sync milestones."
+openwiki_generated: true
 tags: [toolchain-integration, openwiki, gitea, nocodb, ragflow, wikijs, milimax-code, 2026-07-16]
 ---
 # 2026-07-16 工具链打通战报
@@ -1,8 +1,7 @@
 ---
 type: "Reference"
 title: "Open Questions"
-description: "Active, Answered, and Stale unresolved questions about Robin's memory, recurring routines, people, projects, and wiki quality. Source-document TODOs and product questions live on their source pages instead."
+openwiki_generated: true
 tags: [open-questions, unresolved, agent-dong-huiqun-celvivo, chengdu-baile-vs-lidesai-for-ou-xianhong, distributors-3brain-cellink-zero-coverage]
 ---
 # Open Questions
@@ -14,32 +13,8 @@ Unresolved questions about Robin's memory, recurring routines, people, projects,
 ### agent-dong-huiqun-celvivo: which distributor does 董慧群 belong to, and what region / customers / contact info does she cover?
 - Owner: me (Robin)
 - Seen: 2026-07-28
- Evidence: `02-Clients/Agents/董慧群.md` in the Obsidian vault (frontmatter `type: agent`, role: 代理商技术同事, products: CelVivo ClinoStar / ClinoReactor, status: active, last-contact: 2026-07-28). Manifest entry: `~/.openwiki/connectors/git-repo/raw/2026-07-28T18-07-57-114Z/manifest.json` commit `21491578`. 2026-08-07 partial resolution: `02-Clients/Agents/_known_associations.md` (commit `4b237a82`, Hermes Agent hook 4) identifies **济南成全生物科技有限公司 (曹沛起)** as the only ClinoStar-listed agent in the 259-dealer China map — 华北 + 山东 跨区重复登记. Cross-reference at [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) § "8-07 新增：_known_associations.md 索引".
+- Evidence: `02-Clients/Agents/董慧群.md` in the Obsidian vault (frontmatter `type: agent`, role: 代理商技术同事, products: CelVivo ClinoStar / ClinoReactor, status: active, last-contact: 2026-07-28). Manifest entry: `~/.openwiki/connectors/git-repo/raw/2026-07-28T18-07-57-114Z/manifest.json` commit `21491578`. Vault nav: `/sources/git-repo.md` → Notable entities.
- Notes: profile is mostly 待补 (agency company name, region, phone, WeChat, served end-customers, opportunities). Robin was told about 董慧群 via WeChat DM on 2026-07-28 — her role is to help push CelVivo products at the technical / demo / selection stage. The 2026-08-07 `123hook_4` partial-resolution gave a likely candidate (济南成全生物科技有限公司 — same contact 曹沛起 in both 华北表 + 山东表) but the precise link to 董慧群 (and whether she is 济南成全的技术同事, or another dealer) is still unverified. Until confirmed, future agents cannot reason about which CelVivo deals 董慧群 might support or which Chinese pharma R&D / CDMO accounts overlap with her territorial reach. The narrower, still-open question is: **is 董慧群 济南成全生物科技 (曹沛起) 的技术同事, or another CelVivo-aligned agent?**
+- Notes: profile is mostly 待补 (agency company name, region, phone, WeChat, served end-customers, opportunities). Robin was told about 董慧群 via WeChat DM on 2026-07-28 — her role is to help push CelVivo products at the technical / demo / selection stage. Until the agency and region are filled in, future agents cannot reason about which CelVivo deals 董慧群 might support or which Chinese pharma R&D / CDMO accounts overlap with her territory. This is the kind of "ambiguous people/org relationship" gap the brief calls out — fills in as Robin contacts her.
 ### liu-2026-rogers-lab-vs-3brain-relationship: is there any partnership / licensing / competitive pressure between Rogers Lab (Liu 2026) and 3Brain?
 - Owner: me (Robin)
 - Seen: 2026-08-08
 - Evidence: literature flywheel-sync 2026-08-08 — Liu N et al. (2026) Nature Biomedical Engineering, DOI 10.1038/s41551-026-01620-y, Wiki.js Id 1692, SeaFile PDF https://fb.biokingdom.top/f/6da50240729e41bdb369/?dl=1. Deep-read at [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md). Commitment at [`/commitments.md`](/commitments.md) `liu-2026-hd-mea-roadmap-implication`.
 - Notes: Liu 2026 establishes a next-gen shape-conformal porous framework for full-coverage (>90% surface) neural organoid electrophysiology at 3000-8000 channels per organoid (10-50× current 3Brain Accura-3D). Rogers Lab (Northwestern) is a major flexible-electronics / bioelectronics group. Three plausible relationships with 3Brain: (a) **partnership** — Rogers Lab licenses the flexible-electronics framework to 3Brain for productization; (b) **competitive pressure** — Rogers Lab or a spinout company commercializes the framework as a competing HD-MEA product; (c) **academic-only** — Rogers Lab has no commercial intent and 3Brain continues to be the best-in-class commercial HD-MEA. Until this is clarified, Robin cannot advise 3Brain customers on whether to wait for next-gen HD-MEA hardware or buy current Accura-3D now. Future agents reading Liu 2026 should treat the "next-gen direction" framing with caution until the 3Brain roadmap is verified.
 ### chengdu-baile-vs-lidesai-for-ou-xianhong: which 成都 dealer should Robin approach first for 西南医科大学心研所 (殴贤红) CelVivo / 3Brain cross-sell?
 - Owner: me (Robin)
 - Seen: 2026-08-07
 - Evidence: `02-Clients/Agents/_known_associations.md` (Obsidian vault, 2026-08-07 commit `4b237a82`) — 候选代理 A: **成都百乐 (杨军)** — 覆盖川渝黔藏 · 1亿/钻石 · 主营 Bio-Rad/Sartorius/Oxford Nanopore/Cytek/Leica; 候选代理 B: **成都立德赛** — 覆盖川渝云贵陕. End-customer: 西南医科大学心血管研究所 (殴贤红, 四川泸州). Cue: Hermes hook 4 recommended "先联系 成都百乐 (钻石级 1亿, 主营匹配度更高)". Cross-reference: [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) § "8-07 新增：_known_associations.md 索引".
 - Notes: Robin needs to pick the first 成都 dealer to approach for the 殴贤红 CelVivo / 3Brain cross-sell. Two candidates identified in the 2026-08-07 `_known_associations.md` sweep: 成都百乐 (1亿/钻石级, 川渝黔藏 + 主营 Bio-Rad/Sartorius/Oxford Nanopore/Cytek/Leica — overlap with FemtoBiomed / 3Brain product line) vs 成都立德赛 (覆盖川渝云贵陕, 主营待查). Hermes hook 4 default recommendation is 成都百乐, but Robin's existing relationship depth with either dealer is unknown. Until Robin makes the call, the cross-sell cannot be initiated.
 ### distributors-3brain-cellink-zero-coverage: 259 dealer list shows 0 三Brain / 0 Cellink / 0 FemtoBiomed direct agents — is the channel gap real, or is the 8-04 xlsx missing these brands?
 - Owner: me (Robin)
 - Seen: 2026-08-07
 - Evidence: `02-Clients/Agents/_known_associations.md` (Obsidian vault, 2026-08-07 commit `4b237a82`) — product-line hit summary shows only CelVivo (济南成全) directly; 3Brain / Cellink / FemtoBiomed all 0. FemtoBiomed CellShot is documented as a 9X Bio (汇佰生物) direct intermediate, not in the 259 dealer list. Cross-reference: [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) § "8-07 新增：_known_associations.md 索引".
 - Notes: The 2026-08-07 xlsx-baseline scan found zero dealers in the 259-row list that explicitly carry 3Brain HD-MEA or Cellink BIO X. For 3Brain HD-MEA, where Robin has 11+ end-customer dossiers (神经所 / 北京大学 / 北京天坛 / 浙大一附院 / 中科院昆明 / 西南医大 / 贵州医大 / 云南中医药 / 天津创新中药), this is a striking gap — either (a) the 8-04 xlsx is missing the 3Brain agents, or (b) no Chinese distributor has picked up 3Brain and Robin needs to either find/appoint one or sell direct. Until Robin clarifies, the 3Brain-side commercial strategy (channel vs direct) for the +11 known Chinese end-customers remains unresolved.
 ### sharma-2026-retinal-organoid-mea-cross-sell: does the 60-channel MCS MEA route transfer cleanly to 3Brain HD-MEA for vascularized retinal organoid RGC recording?
 - Owner: me (Robin)
 - Seen: 2026-08-08
 - Evidence: literature flywheel-sync 2026-08-08 — Sharma K et al. (2026) Cell Stem Cell 33:253-271.e13, DOI 10.1016/j.stem.5.12.013, PMID 41529691, Wiki.js Id 1678, NocoDB row 700, SeaFile PDF https://fb.biokingdom.top/f/861202f029004d75b456/?dl=1. Deep-read at [`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`](/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md).
 - Notes: Sharma 2026 records vascularized retinal organoid (vRO) W31 ON/OFF/ON-OFF light responses using **60-channel MCS MEA2100-Lite** (not HD-MEA) — 60 channels at 32 kHz, no HD spatial resolution. The RGC fraction (W18: 18.2% vs 1.21% ctrl-RO) and the W31 light responses are clinically meaningful, but the MEA is bottom-surface-only (no 3D spatial resolution). Robin's own flywheel audit flagged product_relevance.rating=4 for 3Brain HD-MEA on the basis that "technical route is transferable" — but the actual technical transfer requires verifying that 3Brain's Accura-3D chip supports opsin + optogenetic + light-response recording at week-31+ retinal organoid maturity (long-duration stability). Without this confirmation, the cross-sell pitch to 3Brain's retinal-organoid accounts is theoretical. Future agents pitching Sharma 2026 to 3Brain prospects should verify the technical route end-to-end before committing.
 <!--
 Structure for new entries:
@@ -1,8 +1,7 @@
 ---
 type: "Reference"
 title: "Personal Logistics"
-description: "Personal errands, appointments, pickups, travel, household/life-admin deadlines, and other non-work logistics. Work commitments live in /commitments.md."
+openwiki_generated: true
 tags: [personal-logistics, life-admin, travel]
 ---
 # Personal Logistics
@@ -1,8 +1,7 @@
 ---
 type: "Reference"
 title: "4-27 SOP 实战 vs 实现差异 (2026-07-27 Tasevska 2025 重做教训)"
-description: "Lessons-learned capture from Robin's 2026-07-27 Tasevska 2025 EJPS deep-read redo — 9-step comparison table of 4-27 SOP范本 vs 7-27 凭印象实操 (Tasevska + Raji 2 篇) vs 4-27 SOP 走通 (Tasevska 重做); detailed PyMuPDF 嵌入图过滤 rules, Ollama 视觉 fallback chain, NocoDB v1 vs v2 protocol, and the 9-step mandatory format. Applies to every literature-deep-read invocation. Companion to `/sources/ldr-report-template.md`."
+openwiki_generated: true
 tags: [literature-deep-read, sop-vs-implementation, lessons-learned, pymupdf, ollama, nocodb, 2026-08-13]
 ---
 # 4-27 SOP 实战 vs 实现差异 (2026-07-27 Tasevska 2025 重做教训)
@@ -1,8 +1,7 @@
 ---
 type: "Reference"
 title: "OpenWiki 速查手册 (Robin 一次聊清, 直接拿来用)"
-description: "Compact OpenWiki cheat-sheet that condenses the 2026-07-27 6-conversation walkthrough into a single ready-to-share document. Designed for one-shot delivery to any agent / colleague / customer / manager who asks 'what is OpenWiki?' — covers the core concept, structure, sync model, and 4 active connectors in one page."
+openwiki_generated: true
 tags: [openwiki, cheat-sheet, reference, onboarding, 2026-07-27]
 ---
 # OpenWiki 速查手册 (Robin 一次聊清, 直接拿来用)
@@ -1,9 +1,7 @@
 ---
 type: "Reference"
 title: "Sources"
-description: "Per-connector evidence indexes and ingestion coverage for the local knowledge wiki; durable synthesis lives on canonical pages."
+openwiki_generated: true
 tags: [sources, connectors, evidence, ingestion, 2026-08-21]
 timestamp: 2026-08-21T18:35:00Z
 ---
 # Sources
@@ -14,9 +12,8 @@ Per-connector evidence indexes. Each connector gets its own page (for example `g
 | Connector | Page | Status |
 | --- | --- | --- |
-| Hacker News (`hackernews-1`, LLM-agent topics) | [/sources/hackernews.md](/sources/hackernews.md) | active (last 2026-08-21 18:00 UTC — tenth pull since 2026-08-07 with an empty / noise-only Algolia lane on vendor queries, all six Algolia queries (`organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents`) returning fully-zero hits — a stricter all-zero Algolia lane than the 2026-08-20 noise-only lane, with no application-domain thematic hits; the strongest named-stack-adjacent item is `49386163` "DeepSeek-v4-flash-vision-exp" 379 pts top+best (DeepSeek vision capability extension — DeepSeek V4 Flash is the canonical DeepSeek-M3 comparison benchmark cited on the `MiniMax-m3` row via benchlm.ai 2026-08-01, V4 vision is a V4-Flash capability milestone that expands into the same multimodal territory MiniMax-M3 occupies per the MyClaw.ai 2026-07-29 confirmation), with three secondary adjacents flagged for traceability: `49390739` Show HN Proliferate 11 pts (self-hostable open-source "Codex for any coding agent" — **Codex CLI is on Robin's named stack** but Proliferate is not, so adjacent-not-promoted per scope), `49378957` "The August 17 outage" 617 pts best / 722 cmts (GitHub blog post-mortem on the August 17 incident affecting Actions + Packages + Pages + Codespaces + API + webhooks; off-scope per scope but the highest-engagement infrastructure post-mortem of the pull), `49390463` "Building an (almost) fully self-hosted, sandboxed, agentic software factory" 16 pts top (4th entry in the 5-day self-hosted-agentic-substrate cluster after DeepSeek Harness 2026-08-13 + machine0 2026-08-18 + OneCLI 2026-08-19; cluster is now a recurring-signal watchlist candidate)) |
+| Hacker News (`hackernews-1`, LLM-agent topics) | [/sources/hackernews.md](/sources/hackernews.md) | active |
-| Git repo (`git-repo-1`, Obsidian vault + OpenWiki wiki) | [/sources/git-repo.md](/sources/git-repo.md) | active (last 2026-08-21 18:09 UTC — 0 new vault commits since 2026-08-20T18:09Z fetch (vault silent for the 5th consecutive fetch, **5 calendar days stale** since the 2026-08-16 Quintard + Guo cluster); 2 new automated wiki commits since 2026-08-20T18:09Z fetch (`b6dc337` daily update 2026-08-21 + `f6c2576` sources-sync 2026-08-21, the seventh consecutive sources-sync re-applying the 2026-08-15 count-data wipe pattern)) |
+| Git repo (`obsidian-robin`, Obsidian vault) | [/sources/git-repo.md](/sources/git-repo.md) | active |
 | Web Search (`web-search-1`, Tavily) | [/sources/web-search.md](/sources/web-search.md) | active (latest pull 2026-08-03; 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, 2026-08-17, 2026-08-18, 2026-08-19, and 2026-08-20 update attempts skipped — connector not enabled, `TAVILY_API_KEY` missing) |
 Additional connectors appear here automatically once they are authenticated and ingested at least once.
@@ -28,9 +25,9 @@ Additional connectors appear here automatically once they are authenticated and
 | Slack | not configured | `openwiki auth slack` | Needs `search:read` for definitive self-message search; otherwise falls back to recent conversations. |
 | Notion | not configured | Notion MCP credentials | Discovery via `openwiki_list_mcp_tools`; do not guess tool names. |
 | X / Twitter | not configured | `OPENWIKI_X_ACCESS_TOKEN` via `openwiki auth x` | Streams: `home_timeline`, `user_posts`, `mentions`, `bookmarks`, `list_posts`. |
-| Web Search | **active** (`web-search-1`) | `TAVILY_API_KEY` (currently empty) | Tavily via LangChain; reads configured queries. Latest successful pull 2026-08-03 18:08 UTC; the 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, 2026-08-17, 2026-08-18, 2026-08-19, 2026-08-20, and 2026-08-21 update attempts were skipped because the connector was not enabled in the runtime registry (ninth consecutive skip on the same code path; nightly searxng-fallback slot for 2026-08-20 is also empty on disk). Evidence at [/sources/web-search.md](/sources/web-search.md). |
+| Web Search | not configured | `TAVILY_API_KEY` | Tavily via LangChain; reads configured queries. |
-| Hacker News | **active** (`hackernews-1`) | _(public, no auth)_ | Public feeds (`top`, `new`, `best`) + Algolia HN search queries. Source-specific query set: `organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents` (LLM-agent topics per the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories"). Last successful pull 2026-08-21 18:00 UTC — **tenth pull since 2026-08-07 with an empty / noise-only Algolia lane on vendor queries** (after the 2026-08-08 03:15 + 2026-08-08 18:00 + 2026-08-13 + 2026-08-15 + 2026-08-16 + 2026-08-18 + 2026-08-19 fully-zero pulls + the 2026-08-10 + 2026-08-12 + 2026-08-17 + 2026-08-20 noise-only pulls where vendor queries returned substring-fragment noise; the **2026-08-21 pull returns to fully-zero across all four vendor queries + both workflow queries — a stricter "all-zero Algolia lane" than the 2026-08-20 noise-only lane**, with no application-domain thematic hits to soften the absence; empty-pulls-on-vendor-queries is normal cadence, not an outage). The strongest named-stack-adjacent item of the pull is `49386163` "DeepSeek-v4-flash-vision-exp" 379 pts top+best (DeepSeek vision capability extension; DeepSeek V4 Flash is the canonical DeepSeek-M3 comparison benchmark cited on the `MiniMax-m3` row via benchlm.ai 2026-08-01 + the unsloth `unsloth/DeepSeek-V4-Flash-GGUF` quantized local-LLM run path; V4 vision is a V4-Flash capability milestone that expands into the same multimodal territory MiniMax-M3 occupies per the MyClaw.ai 2026-07-29 confirmation); three secondary adjacents flagged for traceability: `49390739` Show HN Proliferate 11 pts (self-hostable "Codex for any coding agent" — Codex CLI is on Robin's named stack so this is the strongest named-stack direct cross-walk of the pull by name, but Proliferate is not on the named stack and 11-pt engagement is below the 21-pt OneCLI / 19-pt machine0 / 46-pt MCP Memory / 100-pt vendor release bar; adjacent-not-promoted per scope), `49378957` "The August 17 outage" 617 pts best / 722 cmts (GitHub post-mortem; off-scope per scope but the highest-engagement infrastructure post-mortem of the pull), `49390463` "Building an (almost) fully self-hosted, sandboxed, agentic software factory" 16 pts top (4th entry in the 5-day self-hosted-agentic-substrate cluster after DeepSeek Harness 2026-08-13 + machine0 2026-08-18 + OneCLI 2026-08-19 — cluster is now a recurring-signal watchlist candidate). The 2026-08-20 pull (prior) produced the `class-organoid-3d-bioprinting` theme-row Last-seen refresh 2026-08-12 → 2026-08-20 via the recurrence criterion (the `49366519` Nature organoid-time-passage paper 18 pts + `49373812` Science Alert cross-walk — second neural-organoid HN signal in 9 pulls); that refresh carries forward unchanged into the 2026-08-21 pull (no organoid / 3D-bioprinting item on the 2026-08-21 pull). All four 2026-08-21 adjacents stay adjacent-not-promoted per scope discipline. Evidence at [/sources/hackernews.md](/sources/hackernews.md). |
+| Hacker News | **active** (`hackernews-1`) | _(public, no auth)_ | Public feeds (`top`, `new`, `best`) + Algolia HN search queries. Evidence at [/sources/hackernews.md](/sources/hackernews.md). |
-| Git repo | **active** (`git-repo-1`) | local repo path | Local Obsidian vault at `/home/ldw/workspace` + OpenWiki wiki at `/home/ldw/.openwiki/wiki` (two configured repos per `~/.openwiki/connectors/git-repo/config.json`). Writes compact manifest; repo itself is source of truth. Evidence at [/sources/git-repo.md](/sources/git-repo.md). Last updated 2026-08-21 18:09 UTC — **0 new vault commits in the 24-hour window** (vault silent for the 5th consecutive fetch; the 2026-08-16 Quintard 2024 + Guo 2026 cluster remains the most recent vault activity, **5 calendar days stale**); 2 new automated wiki commits since the 2026-08-20 fetch (`b6dc337` daily update 2026-08-21 + `f6c2576` sources-sync 2026-08-21, the **seventh** consecutive sources-sync re-applying the 2026-08-15 count-data wipe pattern after `997b648` 2026-08-16 + `be49285` 2026-08-17 + `1fc73ae` 2026-08-18 + `dcb53a2` 2026-08-19 + `bd30339` 2026-08-20 + now `f6c2576` 2026-08-21). |
+| Git repo | **active** (`obsidian-robin`) | local repo path | Local Obsidian vault under `~/.openclaw/workspace`. Writes compact manifest; repo itself is source of truth. Evidence at [/sources/git-repo.md](/sources/git-repo.md). |
 ## How new source pages get created
@@ -40,4 +37,4 @@ When a connector ingests for the first time, an update run will:
 2. Create `/sources/<connector>.md` with the ingestion manifest, freshness, and compact evidence notes.
 3. Route durable items into the canonical pages and add a row in `/themes.md` if a recurring signal emerges.
-Until then, the new connector only has a row in the active connectors table above and no evidence page of its own..its own..
+Until then, the new connector only has a row in the active connectors table above and no evidence page of its own.
@@ -1,8 +1,7 @@
 ---
 type: "Reference"
 title: "Agents 代理商档案索引 — 跨 agent CRM 同步"
-description: "Cross-agent index of the Obsidian vault 02-Clients/Agents/* profiles (which agents Robin is actively working with, mapped by vendor product line). Base identity only — sensitive fields (phone / WeChat / email / end-customer list / opportunity value) live only in the private vault. Updated 2026-08-07 with _known_associations.md product-line → agent → end-customer mapping."
+openwiki_generated: true
 tags: [agents, distributors, crm, celvivo, 3brain, cellink, femtobiomed, source]
 ---
 # Agents 代理商档案索引 — 跨 agent CRM 同步
@@ -10,7 +9,7 @@ tags: [agents, distributors, crm, celvivo, 3brain, cellink, femtobiomed, source]
 > 数据源: Obsidian vault `02-Clients/Agents/*.md` (git-repo connector 自动同步)
 > 用途: MiniMax code / Hermes 跨 agent 问 "Robin 当前在跟哪些代理商 / 谁在帮推什么产品"
 > 更新: 自动（`~/.openwiki/update-sources.sh` 每天 02:00 拉一次 mtime,数据写入本页后 commit + push Gitea）
-> 上次同步: **2026-07-28** (current); 2026-08-07 hook 4 partial resolution via `_known_associations.md` (see below)
+> 上次同步: **2026-07-28**
 ## 4 大产品线
@@ -25,7 +24,7 @@ tags: [agents, distributors, crm, celvivo, 3brain, cellink, femtobiomed, source]
 | 姓名 | 角色 | 代理商品牌 | 主推产品 | 首次记录 | 状态 | Vault 路径 |
 |---|---|---|---|---|---|---|
-| 董慧群 | 技术同事 | 待补 (8-07 hook 4 候选: **济南成全生物科技 (曹沛起)**) | CelVivo (ClinoStar / ClinoReactor) | 2026-07-28 | active | `02-Clients/Agents/董慧群.md` |
+| 董慧群 | 技术同事 | 待补 | CelVivo (ClinoStar / ClinoReactor) | 2026-07-28 | active | `02-Clients/Agents/董慧群.md` |
 ## 跟其他工具的互补关系
@@ -57,17 +56,3 @@ tags: [agents, distributors, crm, celvivo, 3brain, cellink, femtobiomed, source]
 - **02-Clients/Agents/** 现只有 1 个条目 — Robin 大部分代理商应该是已有的，需要主动说"把 X 也加进来"
 - 建议 Robin 每接一个新代理商 / 新联系人时 1 句话提示，我立即同步两边
 - 是否要加 **End-Customers/** 同步索引到 OpenWiki（按同样模式）？目前 `02-Clients/End-Customers/西南医科大学心研所-殴贤红.md` 已存在但未在本文件列
 ## 2026-08-07 关联索引 (Hermes hook 4)
 `02-Clients/Agents/_known_associations.md` (commit `4b237a82`, Hermes Agent 2026-08-07 hook 4) maps 现有关联 to 259-dealer 2026-08-07 baseline. Public index (privacy rule preserved):
 | 产品线 | 关联代理 / 中间方 | 关联客户 / 商机 |
 |---|---|---|
 | CelVivo | **济南成全生物科技 (曹沛起)** — 华北 + 山东 跨区 | 董慧群 (技术同事) — 8-07 候选 |
 | FemtoBiomed | **9X Bio (汇佰生物)** — 中间方 (不在 259 dealer list) | TriArm Therapeutics (翁靖傑 上海 CGT/CAR-T, 128 万 Phase1 / 8-10 至 8-14 现场 demo) |
 | 3Brain | 0 家代理 | 11+ end-customer dossiers (西南医大 殴贤红 pending 成都 dealer 2选1) |
 | Cellink | 0 家代理 | — |
 | FemtoBiomed (direct) | 0 家代理 | (9X Bio 中间方 handles) |
 See [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) § "8-07 新增" for full mapping + 待补缺口. Open-question `agent-dong-huiqun-celvivo` and commitment `dong-huiqun-ji-nan-chengquan-link` track the 董慧群 → 济南成全 confirmation.
@@ -1,86 +1,61 @@
 ---
 type: "Reference"
-title: "全国经销商地图 (2026-08-07 时点)"
+title: "全国经销商地图 · 2026-07-24 时点"
-description: "Compact index of Robin's 2026-08-07 China distributor baseline (259 dealers across 7 regions, replacing 261 in the 2026-07-24 baseline) plus the new product-association index _known_associations.md. Surfaces CelVivo ClinoStar → 济南成全 + FemtoBiomed CellShot → 9X Bio → TriArm Therapeutics chain. Routes pricing-sensitive fields to the private Obsidian vault per /sources/agents.md privacy rule."
+openwiki_generated: true
 resource: "/home/ldw/workspace/02-Clients/Agents/全国经销商地图-2026-0807.md"
 tags:
  - distributors
  - china
  - 2026
  - vendors
  - source
 ---
-# 全国经销商地图 · 2026-08-07 时点
+# 全国经销商地图 · 2026-07-24 时点
-> **数据源**: Obsidian vault `02-Clients/Agents/*.md`（git-repo connector 自动同步，2026-08-07 写入 — 替换 2026-07-24 baseline）
+> **数据源**: Obsidian vault `02-Clients/Agents/*.md`（git-repo connector 自动同步，2026-08-07 写入）
-> **覆盖范围**: 全国 7 大区域 / **259** 家生命科学仪器经销商（汇总表口径；明细表 261：差 2 家 = 华北表 74 vs 汇总 72）
+> **覆盖范围**: 全国 7 大区域 / 261 家生命科学仪器经销商
-> **整理**: Hermes Agent（Robin 2026-08-07 11:11 上传 `b7f52af896c1e3a9.xlsx`）
+> **整理**: Hermes Agent（Robin 2026-08-07 上传 `2026经销商信息统计表-全国0724.xlsx`）
 > **关联索引**: `02-Clients/Agents/_known_associations.md`（2026-08-07 added — 5 命中产品-代理映射）
 ## 隐私边界
-按 [`/sources/agents.md`](/sources/agents.md) 既定规则，本文件**只含基础身份**：
+按 [[sources/agents.md]] 既定规则，本文件**只含基础身份**：
 - ✅ 公司名 / 区域 / 主营品牌关键词 / 主战场
 - ❌ **不**含：电话 / 微信 / 邮箱 / 联系人姓名 / 终端客户清单 / 商机金额 / 销售人数
-**详细联系方式** → 必须读 Obsidian vault `02-Clients/Agents/{区域}-2026-0807.md`（git 私有）
+**详细联系方式** → 必须读 Obsidian vault `02-Clients/Agents/{区域}-2026-0724.md`（git 私有）
 ## 关键统计
 | 维度 | 数值 |
 |---|---|
-| 总经销商数 | **259** 家（汇总表口径；明细表 261 — 差 2 家 = 华北表 74 vs 汇总 72）|
+| 总经销商数 | **261** 家（明细表口径，比汇总表"公司数量"259 多 2 家 — 差异来自华北表）|
 | 覆盖区域 | 7 大区 |
 | 平均每地区 | 37 家 |
 | 上次 baseline | 2026-07-24（261 家） |
 | 净变更 | -2 家（华北：74 → 72） |
-| 地区 | 家数 (8-07) | 家数 (7-24) | 净变更 | 主战场 |
+| 地区 | 家数 | 占% | 主战场 |
-|---|---:|---:|---:|---|
+|---|---|---|---|
-| 华北 | 72 | 74 | -2 | 北京 (54家) |
+| 华北 | 74 | 28.4% | 北京 (54家) |
-| 华东 | 68 | 68 | 0 | 上海 (53家) |
+| 华东 | 68 | 26.1% | 上海 (53家) |
-| 华南 | 62 | 62 | 0 | 广州 (44家) |
+| 华南 | 62 | 23.8% | 广州 (44家) |
-| 山东 | 25 | 25 | 0 | 济南 (22家) |
+| 山东 | 25 | 9.6% | 济南 (22家) |
-| 湖北 | 19 | 19 | 0 | 武汉 (12家) |
+| 湖北 | 19 | 7.3% | 武汉 (12家) |
-| 西北 | 6 | 6 | 0 | 西安 (6家) |
+| 西北 | 6 | 2.3% | 西安 (6家) |
-| 西南 | 7 | 7 | 0 | 重庆 (3家) |
+| 西南 | 7 | 2.7% | 重庆 (3家) |
 | **TOTAL** | **259** | **261** | **-2** | — |
 ### 8-07 baseline 独有的数据异常
 - **济南成全生物科技有限公司 (曹沛起)** 同时登记在 **华北表 + 山东表**（geographic
  cross-region duplicate，合法 — 山东公司辐射华北是常见经销模式）。 This is the
  **only CelVivo ClinoStar agent** in the 259-dealer list — the hook to
  cross-reference with `02-Clients/Agents/董慧群.md`（见
  [`/open-questions.md`](/open-questions.md) `agent-dong-huiqun-celvivo`）
 - **华北表 序号 63 / 67** 两个空 company-name 字段（继承 from 2026-07-24
  baseline）；明细表 74 vs 汇总表 72 的差 2 家，就是这 2 行
 ## 与 4 大产品线的潜在关联
-> 以下统计仅展示**代理过我们 4 大产品线品牌**的经销商家数。**不等于**Robin 实际在跟的代理商 — 那份见 [`/sources/agents.md`](/sources/agents.md)。
+> 以下统计仅展示**代理过我们 4 大产品线品牌**的经销商家数。**不等于**Robin 实际在跟的代理商 — 那份见 [[sources/agents.md]]。
-| 产品线 | 涉及品牌 | 全国关联经销商数 | 8-07 命中 |
+| 产品线 | 涉及品牌 | 全国关联经销商数 |
-|---|---|---:|---|
+|---|---|---|
-| CelVivo (ClinoStar / ClinoReactor) | CelVivo / ClinoStar | 1 | **济南成全生物科技 (曹沛起)** — 华北 + 山东 (跨区重复) |
+| CelVivo (ClinoStar / ClinoReactor) | CelVivo / ClinoStar | 待详细匹配 |
-| FemtoBiomed (CellShot / PROLIVA) | Femtobiomed / CellShot | 0 | (9X Bio / 汇佰生物 is direct intermediate, 不在 259 dealer list) |
+| 3Brain (HD-MEA) | 3Brain | 待详细匹配 |
-| 3Brain (HD-MEA) | 3Brain | 0 | — |
+| Cellink (BIO X) | Cellink | 待详细匹配 |
-| Cellink (BIO X) | Cellink | 0 | — |
+| FemtoBiomed (CellShot / PROLIVA) | Femtobiomed / CellShot | 待详细匹配 |
 **详细 + 客户-代理映射：** 见 `02-Clients/Agents/_known_associations.md`（2026-08-07 added）。
 ## 详细分地区索引（不含敏感字段）
- 华北 (72 家) — 见 Obsidian vault `02-Clients/Agents/华北-2026-0807.md`
+- 华北 (74 家) — 见 Obsidian vault `02-Clients/Agents/华北-2026-0724.md`
- 华东 (68 家) — 见 Obsidian vault `02-Clients/Agents/华东-2026-0807.md`
+- 华东 (68 家) — 见 Obsidian vault `02-Clients/Agents/华东-2026-0724.md`
- 华南 (62 家) — 见 Obsidian vault `02-Clients/Agents/华南-2026-0807.md`
+- 华南 (62 家) — 见 Obsidian vault `02-Clients/Agents/华南-2026-0724.md`
- 山东 (25 家) — 见 Obsidian vault `02-Clients/Agents/山东-2026-0807.md`
+- 山东 (25 家) — 见 Obsidian vault `02-Clients/Agents/山东-2026-0724.md`
- 湖北 (19 家) — 见 Obsidian vault `02-Clients/Agents/湖北-2026-0807.md`
+- 湖北 (19 家) — 见 Obsidian vault `02-Clients/Agents/湖北-2026-0724.md`
- 西北 (6 家) — 见 Obsidian vault `02-Clients/Agents/西北-2026-0807.md`
+- 西北 (6 家) — 见 Obsidian vault `02-Clients/Agents/西北-2026-0724.md`
- 西南 (7 家) — 见 Obsidian vault `02-Clients/Agents/西南-2026-0807.md`
+- 西南 (7 家) — 见 Obsidian vault `02-Clients/Agents/西南-2026-0724.md`
 > **2026-07-24 baseline 文件** (`*2026-0724.md` × 7 + `全国经销商地图-2026-0724.md`) 仍 in repo but 已被 8-07 替换。Robin upload 2026-08-07 11:11 时是 **8-04 同名 + 新增 2-3 家** = 259 汇总口径。
 ## 品牌关键词地图（粗略）
@@ -88,82 +63,32 @@ tags:
 | 品牌 | 全国 | 华北 | 华东 | 华南 | 山东 | 湖北 | 西北 | 西南 |
 |---|---|---|---|---|---|---|---|---|
-| BI | 19 | 1 | 5 | 0 | 7 | 3 | 1 | 2 |
+| BI | 19 | 1 | 5 | 0 | 7 | 3 | 1 | 2 | 
-| Thermo | 19 | 2 | 5 | 2 | 6 | 1 | 1 | 2 |
+| Thermo | 19 | 2 | 5 | 2 | 6 | 1 | 1 | 2 | 
-| Bio-Rad | 11 | 0 | 4 | 0 | 3 | 1 | 1 | 2 |
+| Bio-Rad | 11 | 0 | 4 | 0 | 3 | 1 | 1 | 2 | 
-| 赛默飞 | 8 | 3 | 0 | 3 | 0 | 0 | 1 | 1 |
+| 赛默飞 | 8 | 3 | 0 | 3 | 0 | 0 | 1 | 1 | 
-| 安捷伦 | 7 | 2 | 0 | 2 | 3 | 0 | 0 | 0 |
+| 安捷伦 | 7 | 2 | 0 | 2 | 3 | 0 | 0 | 0 | 
-| 蔡司 | 6 | 1 | 1 | 4 | 0 | 0 | 0 | 0 |
+| 蔡司 | 6 | 1 | 1 | 4 | 0 | 0 | 0 | 0 | 
-| Cytiva | 6 | 0 | 3 | 1 | 1 | 1 | 0 | 0 |
+| Cytiva | 6 | 0 | 3 | 1 | 1 | 1 | 0 | 0 | 
-| 伯乐 | 6 | 0 | 1 | 2 | 0 | 1 | 1 | 1 |
+| 伯乐 | 6 | 0 | 1 | 2 | 0 | 1 | 1 | 1 | 
-| 徕卡 | 6 | 0 | 0 | 4 | 0 | 1 | 0 | 1 |
+| 徕卡 | 6 | 0 | 0 | 4 | 0 | 1 | 0 | 1 | 
-| 赛多利斯 | 5 | 1 | 0 | 2 | 1 | 0 | 0 | 1 |
+| 赛多利斯 | 5 | 1 | 0 | 2 | 1 | 0 | 0 | 1 | 
-| Eppendorf | 5 | 1 | 1 | 0 | 2 | 1 | 0 | 0 |
+| Eppendorf | 5 | 1 | 1 | 0 | 2 | 1 | 0 | 0 | 
-| Leica | 5 | 0 | 1 | 0 | 1 | 1 | 0 | 2 |
+| Leica | 5 | 0 | 1 | 0 | 1 | 1 | 0 | 2 | 
-| Beckman | 4 | 0 | 3 | 0 | 1 | 0 | 0 | 0 |
+| Beckman | 4 | 0 | 3 | 0 | 1 | 0 | 0 | 0 | 
-| Merck | 4 | 0 | 1 | 1 | 2 | 0 | 0 | 0 |
+| Merck | 4 | 0 | 1 | 1 | 2 | 0 | 0 | 0 | 
-| Waters | 4 | 0 | 1 | 0 | 2 | 0 | 0 | 1 |
+| Waters | 4 | 0 | 1 | 0 | 2 | 0 | 0 | 1 | 
-| Azure | 3 | 1 | 0 | 0 | 1 | 1 | 0 | 0 |
+| Azure | 3 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 
-| Bruker | 3 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
+| Bruker | 3 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 
-| Oxford Nanopore | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 1 |
+| Oxford Nanopore | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 
-| Agilent | 3 | 1 | 0 | 0 | 2 | 0 | 0 | 0 |
+| Agilent | 3 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 
-| Sartorius | 3 | 1 | 0 | 0 | 1 | 0 | 0 | 1 |
+| Sartorius | 3 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 
 ## 8-07 新增：`_known_associations.md` 索引
 `02-Clients/Agents/_known_associations.md` 是 2026-08-07 由 Hermes Agent
 hook 4（4 个经销商管理 Hook 升级）输出的产品-代理-客户映射。摘录：
 ### CelVivo / ClinoStar 链
 | 项 | 内容 |
 |---|---|
 | 代理 | **济南成全生物科技有限公司 (曹沛起)** — 华北 + 山东 跨区重复登记 |
 | 关联中间方 | 董慧群 (CelVivo 技术同事) — agency 待 Robin 确认 |
 | 关联客户 | (待 Robin 确认) |
 | 关联商机 | (待 Robin 确认) |
 ### FemtoBiomed (CellShot / PROLIVA) 链
 | 项 | 内容 |
 |---|---|
 | 中间方 | **9X Bio (汇佰生物)** — FemtoBiomed CellShot / PROLIVA 中国中间方 |
 | 259 dealer 命中 | 0 家 (9X Bio 直接对接 TriArm, 不在代理渠道表里) |
 | 关联终端客户 | **TriArm Therapeutics (翁靖傑, 上海 CGT/CAR-T)** |
 | 关联商机 | `02-Active-Deals/CellShot-TriArm-Demo-*` (4 个文件, 7-17 会议 + 7-20 计划 v1/v2) |
 | 备注 | 128 万 Phase1 / 8-10 至 8-14 现场 demo |
 ### 西南医科大学心研所 殴贤红 → 2 选 1
 | 项 | 内容 |
 |---|---|
 | 地区 | 四川泸州 |
 | 候选代理 A | **成都百乐 (杨军)** — 覆盖川渝黔藏 · 1亿/钻石 · 主营 Bio-Rad/Sartorius/Oxford Nanopore/Cytek/Leica |
 | 候选代理 B | **成都立德赛** — 覆盖川渝云贵陕 |
 | 关联商机 | (待 Robin 决策) |
 | 推荐 | **先联系 成都百乐** (钻石级 1亿, 主营匹配度更高) |
 ### 产品线代理映射（259 dealer 表已知）
 | 产品线 | 命中代理 | 关联客户 |
 |---|---|---|
 | CelVivo | 济南成全 (曹沛起) | 董慧群关联 |
 | FemtoBiomed | 0 (9X Bio 中间方) | TriArm |
 | 3Brain | 0 | — |
 | Cellink | 0 | — |
 ### 待补缺口（Robin 优先补全）
 1. 董慧群 是 济南成全的哪个具体技术同事? 还是另一家代理?
 2. 西南医大 殴贤红 → 成都百乐 还是 成都立德赛?
 3. 邓昊伦 (02-Contacts/) 蛇类神经方向 → 3Brain HD-MEA 拜访?
 4. 259 dealer 表里**无 3Brain / Cellink 代理** → 缺销售漏掉了 or 要主动找?
 ## 与现有 sources/agents.md 关系
- [`/sources/agents.md`](/sources/agents.md) 记录**Robin 实际在跟的代理商**（按 4 大产品线维度，目前 1 个: 董慧群）→ "在跟"
+- `sources/agents.md` 记录**Robin 实际在跟的代理商**（按 4 大产品线维度，目前 1 个: 董慧群）→ "在跟"
- `/sources/distributors-china-2026.md`（本文件）记录**全国 259 家渠道全量 (8-07 baseline)** + 8-07 新增 `_known_associations.md` 索引 → "全景 + 关联"
+- `sources/distributors-china-2026.md`（本文件）记录**全国 261 家渠道全量** → "全景"
- 两份互补，**不可合并**：合并会污染"在跟"列表（混入未接触的 258 家）
+- 两份互补，**不可合并**：合并会污染"在跟"列表（混入未接触的 260 家）
 ## 关键数据缺口
@@ -178,5 +103,4 @@ hook 4（4 个经销商管理 Hook 升级）输出的产品-代理-客户映射
 ---
 *由 Hermes Agent 自动整理 · 2026-08-07*
-*本文件不含敏感信息，按 [`/sources/agents.md`](/sources/agents.md) 隐私规则*
+*本文件不含敏感信息，按 [[sources/agents.md]] 隐私规则*
 *Raw manifest: `~/.openwiki/connectors/git-repo/raw/2026-08-08T18-11-31-856Z/manifest.json`*
@@ -1,8 +1,7 @@
 ---
 type: "Reference"
 title: "飞书邮箱 (Robin customer mailbox)"
-description: "Planned cross-agent mailbox sync target for Robin's Feishu (飞书) mailbox (imap.feishu.cn:993 / imap.larksuite.com:993) — would let MiniMax code / Hermes recall 'what did Robin last discuss with customer X' from email metadata + summaries. Not yet provisioned — IMAP credentials + update script + crontab still pending Robin setup; this page documents the planned configuration and the sync policy that will be applied once provisioned."
+openwiki_generated: true
 tags: [feishu-mail, evidence-index, source, mailbox, planned, 2026-08-13]
 ---
 # 飞书邮箱 (Robin customer mailbox)
@@ -1,29 +1,25 @@
 # Files
- [4-27 SOP 实战 vs 实现差异 (2026-07-27 Tasevska 2025 重做教训)](2026-07-27-4-27-sop-vs-implementation.md) - Lessons-learned capture from Robin's 2026-07-27 Tasevska 2025 EJPS deep-read redo — 9-step comparison table of 4-27 SOP范本 vs 7-27 凭印象实操 (Tasevska + Raji 2 篇) vs 4-27 SOP 走通 (Tasevska 重做); detailed PyMuPDF 嵌入图过滤 rules, Ollama 视觉 fallback chain, NocoDB v1 vs v2 protocol, and the 9-step mandatory format. Applies to every literature-deep-read invocation. Companion to `/sources/ldr-report-template.md`.
+- [4-27 SOP 实战 vs 实现差异 (2026-07-27 Tasevska 2025 重做教训)](2026-07-27-4-27-sop-vs-implementation.md)
- [Agents 代理商档案索引 — 跨 agent CRM 同步](agents.md) - Cross-agent index of the Obsidian vault 02-Clients/Agents/* profiles (which agents Robin is actively working with, mapped by vendor product line). Base identity only — sensitive fields (phone / WeChat / email / end-customer list / opportunity value) live only in the private vault. Updated 2026-08-07 with _known_associations.md product-line → agent → end-customer mapping.
+- [Agents 代理商档案索引 — 跨 agent CRM 同步](agents.md)
- [全国经销商地图 (2026-08-07 时点)](distributors-china-2026.md) - Compact index of Robin's 2026-08-07 China distributor baseline (259 dealers across 7 regions, replacing 261 in the 2026-07-24 baseline) plus the new product-association index _known_associations.md. Surfaces CelVivo ClinoStar → 济南成全 + FemtoBiomed CellShot → 9X Bio → TriArm Therapeutics chain. Routes pricing-sensitive fields to the private Obsidian vault per /sources/agents.md privacy rule.
+- [全国经销商地图 · 2026-07-24 时点](distributors-china-2026.md)
- [飞书邮箱 (Robin customer mailbox)](feishu-mail.md) - Planned cross-agent mailbox sync target for Robin's Feishu (飞书) mailbox (imap.feishu.cn:993 / imap.larksuite.com:993) — would let MiniMax code / Hermes recall 'what did Robin last discuss with customer X' from email metadata + summaries. Not yet provisioned — IMAP credentials + update script + crontab still pending Robin setup; this page documents the planned configuration and the sync policy that will be applied once provisioned.
+- [飞书邮箱 (Robin customer mailbox)](feishu-mail.md)
- [Git repo — evidence index (Obsidian vault, Robin)](git-repo.md) - Compact manifest of Robin's Obsidian vault + the local OpenWiki wiki, ingested through the local git-repo connector. Two configured repos: obsidian-vault at /home/ldw/workspace (main branch, HEAD a4fa5a32, 2026-08-16, **0 new vault commits in the 2026-08-20T18:09Z → 2026-08-21T18:09Z 24-hour window — vault is silent for the 5th consecutive fetch after the 2026-08-16 Quintard + Guo cluster, 5 calendar days stale**) and openwiki-wiki at /home/ldw/.openwiki/wiki (main branch, HEAD f6c2576, 2026-08-21, **2 new automated wiki commits in the 2026-08-20T18:09Z → 2026-08-21T18:09Z window: `b6dc337` daily update 2026-08-21 + `f6c2576` sources-sync 2026-08-21 — the seventh consecutive sources-sync re-applying the 2026-08-15 count-data wipe pattern**). This page is a navigation index — content ingestion (paper deep reads, sales scripts, customer files) happens via the Hermes skill and RAGFlow, not here.
+- [Git repo — evidence index (Obsidian vault, Robin)](git-repo.md)
- [Hacker News — evidence index](hackernews.md) - Compact evidence trail for the Hacker News connector (hackernews-1, Robin-curated life-sciences + AI workflow). Synthesis lives on /themes.md, /commitments.md, etc.; this page only records ingestion coverage and notable items.
+- [Hacker News — evidence index](hackernews.md)
- [文献精读 Master Template (Robin 7-27 实战版, "真适合浏览" 1 文件)](ldr-report-template.md) - Master template for Robin's literature-deep-read (LDR) pipeline — consolidates 4 literature skills (`literature-deep-read` / `research` / `review` / `curation-for-sales`) into a single 8-rule + 3-trigger + 5-section "真适合浏览" report format. Synthesized from 4-27 SOP范本 + 7-27 实战 lessons (Tasevska / Raji / Bosnjakovic). Triggers "精读吧" / "发 wikijs" / "入库" / "A" / Id/DOI/PMID/PDF signals into 4-step精简 or 8-step完整 flows. PDF全文必传 + PyMuPDF xref去重 + 9项强制 + SeaFile hostname `fb.biokingdom.top` + NocoDB v1 JSON + 3张真图 + `journal-year-topic` 报告路径.
+- [文献精读 Master Template (Robin 7-27 实战版, "真适合浏览" 1 文件)](ldr-report-template.md)
- [Bosnjakovic 2025 PAH 3D 球体代谢组学: 跟 CelVivo ClinoStar dynamic culture 关系 (Bosnjakovic 2025 bioRxiv)](literature-cel-bosnjakovic-2025-pah-deepread.md) - Deep-read synthesis of Bosnjakovic A et al. 2025 bioRxiv preprint (DOI 10.1101/2025.07.10.663939v1, 2025-07-10) — 21-day mature HepG2 3D spheroids with graded non-cytotoxic BaP + BBF (PAH代表物) exposure for metabolomics biomarker discovery. Robin's connection: 3D spheroid protocol maps directly onto CelVivo ClinoStar dynamic culture; supports PAH exposure metabolomics positioning for hepatotoxicity / NAFLD modeling applications. 精读 2026-07-27.
+- [Bosnjakovic 2025 PAH 3D 球体代谢组学: 跟 CelVivo ClinoStar dynamic culture 关系 (Bosnjakovic 2025 bioRxiv)](literature-cel-bosnjakovic-2025-pah-deepread.md)
- [CelVivo 2026 脑类器官白皮书《Breaking the Bias》精读索引](literature-celvivo-brain-whitepaper-2026.md) - Deep-read synthesis of CelVivo ApS (Denmark) 2026 whitepaper 'Breaking the Bias: Addressing the challenges facing optimal neural organoid development' (16 pages, translated + 精读 2026-07-28). Synthesizes CelVivo's positioning on neural organoid long-term culture and the clinical-translation path. Direct vendor-channel evidence for the CelVivo ClinoStar / ClinoReactor portfolio on brain organoid applications — companion to academic literature flywheel-sync.
+- [CelVivo 2026 脑类器官白皮书《Breaking the Bias》精读索引](literature-celvivo-brain-whitepaper-2026.md)
- [Liu 2026 — shape-conformal porous frameworks for full coverage of neural organoid electrophysiology (Nat Biomed Eng, Rogers Lab)](literature-liu-2026-nbme-shape-conformal-organoid-deepread.md) - Deep-read synthesis of Liu N et al. (2026) Nature Biomedical Engineering — shape-conformal porous framework + adaptive genetic algorithm + flexible-electronics microlattice for full-surface (>90%) neural organoid electrophysiology at 3000-8000 channels per organoid (vs 200-1000 traditional MEA); weeks-long stable recording; epilepsy/AD disease modeling.
+- [Raji 2026 (hMOs + 3Brain HD-MEA) — 7-27 增补版 (跟 7-01 矩阵集成)](literature-raji-2026-deepread.md)
- [Miao 2025 — co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids (Cell v2)](literature-miao-2025-cell-vascularization-v2-deepread.md) - Deep-read synthesis of Miao Y et al. (2025) Cell v2 — single 3D EB co-induction of mesoderm+endoderm yields vHLPO with 7% ECs vs traditional 0%; FOXF1 mutation ACDMPV disease modeling; lung + gut organoid vascularization.
+- [3D 打印缓释 HCTZ 片: 跟 Cellink BIO X 挤出打印 (Tasevska 2025 EJPS)](literature-tasevska-2025-deepread.md)
- [Raji 2026 (hMOs + 3Brain HD-MEA) — 7-27 增补版 (跟 7-01 矩阵集成)](literature-raji-2026-deepread.md) - Deep-read synthesis of Raji H, Bertoli F, Perez MJ, Lam A, Volpicelli-Daley LA, Deleidi M. 2026 Molecular Psychiatry (Nature 子刊, s41380-026-03667-4, DOI 10.1038/s41380-026-03667-4, IF 11) — human midbrain organoids (hMOs) with WNT modulation, dopaminergic neuron differentiation, bioreactor culture, and 3Brain HD-MEA electrophysiology for Parkinson's disease modeling. 7-01 实战范本 (page 1622) + 7-27 增补版 integrated with 3-paper 3Brain MEA matrix (Raji / Pali / Wei) and 4 product-line complementarity chain (CelVivo ClinoStar + Cellink BIO X + 3Brain HD-MEA + FemtoBiomed CellShot).
+- [Literature Deep-Reads — 跨 agent 精读索引](literature.md)
 - [Sharma 2026 — vascularized retinal organoid RGC survival and maturation (Cell Stem Cell)](literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md) - Deep-read synthesis of Sharma K et al. (2026) Cell Stem Cell — transiently vascularized human retinal organoids with RGC 18.2% vs ctrl-RO 1.21% at week 18, W31 ON/OFF/ON-OFF light responses, C3 endothelial monolayer integration strategy.
 - [3D 打印缓释 HCTZ 片: 跟 Cellink BIO X 挤出打印 (Tasevska 2025 EJPS)](literature-tasevska-2025-deepread.md) - Deep-read synthesis of Tasevska T et al. 2025 European Journal of Pharmaceutical Sciences 206:106998 (DOI 10.1016/j.ejps.2024.106998, 精读 2026-07-27) — first systematic SSE semi-solid extrusion vs DLP digital-light-processing comparison for sustained-release HCTZ (hydrochlorothiazide) tablets, with focus on SSE matching Cellink BIO X extrusion principle. Supports Robin's 3D-printed personalized-dose / sustained-release positioning and SSE extruder cross-sell narrative for Cellink BIO X accounts.
 - [Literature Deep-Reads — cross-agent deep-read index](literature.md) - Cross-agent index of Robin's literature deep-reads across the 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed) and adjacent application domains (organoid IRB / ethics, vascularized organoids, microfluidic / organ-on-chip). Backed by the Obsidian vault 04-Literature/Deep-Reads/ and the flywheel-sync pipeline; synthesis pages are linked per paper.
 - [NocoDB 文献库索引 — 跨 agent 数据层](nocodb.md)
- [OpenWiki Upgrade Drift (auto-generated)](openwiki-version-drift.md)
+- [OpenWiki 速查手册 (Robin 一次聊清, 直接拿来用)](OpenWiki%E9%80%9F%E6%9F%A5%E6%89%8B%E5%86%8C.md)
- [OpenWiki 速查手册 (Robin 一次聊清, 直接拿来用)](OpenWiki%E9%80%9F%E6%9F%A5%E6%89%8B%E5%86%8C.md) - Compact OpenWiki cheat-sheet that condenses the 2026-07-27 6-conversation walkthrough into a single ready-to-share document. Designed for one-shot delivery to any agent / colleague / customer / manager who asks 'what is OpenWiki?' — covers the core concept, structure, sync model, and 4 active connectors in one page.
+- [RAGFlow 文档采样索引](ragflow-documents.md)
- [RAGFlow 文档采样索引](ragflow-documents.md) - Document-level sample index of Robin's RAGFlow instance (http://10.10.10.254:9980) — 18 KBs / 32709 total docs / 401 sample entries (last sync 2026-08-03). Captures the 30-doc-per-request server-side limit + offset bug that forces 12 large KBs to single-page samples. Lets MiniMax code / Hermes see 'what's in each KB' without SQL queries; complements `/sources/ragflow.md` (KB-level health + counts).
+- [Ragflow](ragflow.md)
- [RAGFlow 全文检索索引 (Robin KB system)](ragflow.md)
+- [Sources](README.md)
- [Sources](README.md) - Per-connector evidence indexes and ingestion coverage for the local knowledge wiki; durable synthesis lives on canonical pages.
+- [RustDesk 自建 hbbs 完整配置笔记 (2026-08-05)](rustdesk-sop.md)
- [RustDesk 自建 hbbs 完整配置笔记 (2026-08-05)](rustdesk-sop.md) - End-to-end deployment note for Robin's self-hosted RustDesk relay server (hbbs + hbbr) — Unraid NAS container (10.10.10.254) + OpenWrt reverse-proxy (10.10.10.252) + Tencent Light Cloud (43.160.207.177) + ITX client (192.168.31.14), with permanent password + key config. Supports remote control of the ITX 24h host (per `/commitments.md` `itx-24h-host-build-2026-q3`) and Robin's travel-laptop remote-access workflow.
+- [CelVivo 销售弹药清单 (2026-07-16 实战索引)](sales-ammunition.md)
 - [CelVivo 销售弹药清单 (2026-07-16 实战索引)](sales-ammunition.md) - Sales ammunition index for CelVivo ClinoStar / ClinoReactor — price-book SKUs (ClinoReactor 12-pack, ClinoStar, SP5D-24W, Demo kit), 8-protocol SOP series (ClinoReactor prep / media change / organoid gardening / speed-tuning / alginate / VitroGel), and 5 organ-specific application cases (HepG2, FTC-133, SCLC, TNBC, ClinoStar vs Orbital Shaker). Sources from RAGFlow CelVivo KB + CelVivo commercial KB; manually curated from Robin + Hermes 实战 lessons. Used by any agent answering CelVivo ClinoReactor pricing / demo / customer-pitch queries.
 - [SeaFile 大文件存储索引](seafile.md)
- [CelVivo + Vault 实时 mtime 快照 (2026-07-16 快照)](vault-mtime-snapshot-2026-07-16.md) - Historical mtime snapshot of Robin's Obsidian vault from 2026-07-16 — captures CelVivo deep-read activity (0 new entries in the 7-day window 2026-07-09 → 2026-07-16; last activity 2026-07-05), 6 entries in the 30-day window, and ClinoReactor keyword hits. Provides a baseline reference for cross-agent vault state because WSL laptop vault is not directly readable from container agents. Pre-dates the 2026-08-07 distributor refresh + 2026-08-12 Liang 2026 / 2026-08-13 Review/ subfolder activity — superseded by `/themes/05-robin-research.md` for current vault state.
+- [CelVivo + Vault 实时 mtime 快照 (2026-07-16 快照)](vault-mtime-snapshot-2026-07-16.md)
- [Web Search Evidence](web-search.md) - Compact, source-backed evidence and ingestion coverage for the web-search-1 Tavily lane tracking CelVivo, 3Brain, Cellink, and related organoid news.
+- [Web Search Evidence](web-search.md)
 - [Wiki.js 索引 — 跨 agent 文档发布层](wikijs.md)
@@ -1,8 +1,7 @@
 ---
 type: "Reference"
 title: "文献精读 Master Template (Robin 7-27 实战版, \"真适合浏览\" 1 文件)"
-description: "Master template for Robin's literature-deep-read (LDR) pipeline — consolidates 4 literature skills (`literature-deep-read` / `research` / `review` / `curation-for-sales`) into a single 8-rule + 3-trigger + 5-section \"真适合浏览\" report format. Synthesized from 4-27 SOP范本 + 7-27 实战 lessons (Tasevska / Raji / Bosnjakovic). Triggers \"精读吧\" / \"发 wikijs\" / \"入库\" / \"A\" / Id/DOI/PMID/PDF signals into 4-step精简 or 8-step完整 flows. PDF全文必传 + PyMuPDF xref去重 + 9项强制 + SeaFile hostname `fb.biokingdom.top` + NocoDB v1 JSON + 3张真图 + `journal-year-topic` 报告路径."
+openwiki_generated: true
 tags: [ldr-template, literature-deep-read, sop, reference, 2026-08-13]
 ---
 # 文献精读 Master Template (Robin 7-27 实战版, "真适合浏览" 1 文件)
@@ -29,7 +28,8 @@ tags: [ldr-template, literature-deep-read, sop, reference, 2026-08-13]
 | 3. **9 项强制 + 创新点/局限性/学术启示 3 段** (4-27 SOP page 946 标杆) | 7-27 教训 (7-17 2 篇缺 3 段) | 模板下面 §3 |
 | 4. **SeaFile URL hostname `fb.biokingdom.top`** (不是少 o) | 7-27 教训 (Tasevska 5 URL 错) | 验证 share-link 真能开 |
 | 5. **NocoDB v1 + JSON body** (4-27 SOP 实战新发现, 范本 v2 失败 3 次) | 7-27 Tasevska 入库 | `POST /api/v1/db/data/wzg1wtad/p2z4g0s687axyvu/{table_id}` |
-| 6. **3 张真图 `![]()`** (SeaFile URL), 不**只**文字图说啥 | 7-27 教训 (Tasevska 重做/Raji 增补版漏图) | markdown image syntax (`alt text` + parenthesized URL), 3 段三段式图注 |
+<!-- openwiki: broken internal link [url] file "url" does not exist. Fix the href or restore the target, then delete this comment. -->
 | 6. **3 张真图 `![]()`** (SeaFile URL), 不**只**文字图说啥 | 7-27 教训 (Tasevska 重做/Raji 增补版漏图) | `!\[alt\](url)` markdown, 3 段三段式图注 |
 | 7. **报告路径 `journal-year-topic` (4-27 SOP 范本)** | 7-27 教训 (我用过 `tasevska-2025-3d-printed-hctz` 不规范) | `ejps-2025-hctz-sse-3d-printing` 风格 |
 | 8. **精简 4 步 vs 完整 8 步按 Robin 信号自动判断** | 7-27 实战 (Tasevska 简化 App Note 类) | 模板下面 §2 |
@@ -1,8 +1,7 @@
 ---
 type: "Reference"
 title: "Bosnjakovic 2025 PAH 3D 球体代谢组学: 跟 CelVivo ClinoStar dynamic culture 关系 (Bosnjakovic 2025 bioRxiv)"
-description: "Deep-read synthesis of Bosnjakovic A et al. 2025 bioRxiv preprint (DOI 10.1101/2025.07.10.663939v1, 2025-07-10) — 21-day mature HepG2 3D spheroids with graded non-cytotoxic BaP + BBF (PAH代表物) exposure for metabolomics biomarker discovery. Robin's connection: 3D spheroid protocol maps directly onto CelVivo ClinoStar dynamic culture; supports PAH exposure metabolomics positioning for hepatotoxicity / NAFLD modeling applications. 精读 2026-07-27."
+openwiki_generated: true
 tags: [literature-deep-read, celvivo-clinostar, hepG2, PAH, metabolomics, 3d-spheroid, 2026-08-13]
 ---
 # Bosnjakovic 2025 PAH 3D 球体代谢组学: 跟 CelVivo ClinoStar dynamic culture 关系 (Bosnjakovic 2025 bioRxiv)
@@ -1,8 +1,7 @@
 ---
 type: "Reference"
 title: "CelVivo 2026 脑类器官白皮书《Breaking the Bias》精读索引"
-description: "Deep-read synthesis of CelVivo ApS (Denmark) 2026 whitepaper 'Breaking the Bias: Addressing the challenges facing optimal neural organoid development' (16 pages, translated + 精读 2026-07-28). Synthesizes CelVivo's positioning on neural organoid long-term culture and the clinical-translation path. Direct vendor-channel evidence for the CelVivo ClinoStar / ClinoReactor portfolio on brain organoid applications — companion to academic literature flywheel-sync."
+openwiki_generated: true
 tags: [literature-deep-read, celvivo, brain-organoid, clinostat, long-term-culture, whitepaper, vendor-channel, 2026-08-13]
 ---
 # CelVivo 2026 脑类器官白皮书《Breaking the Bias》精读索引
@@ -1,110 +0,0 @@
 ---
 type: "Reference"
 title: "Liu 2026 — shape-conformal porous frameworks for full coverage of neural organoid electrophysiology (Nat Biomed Eng, Rogers Lab)"
 description: "Deep-read synthesis of Liu N et al. (2026) Nature Biomedical Engineering — shape-conformal porous framework + adaptive genetic algorithm + flexible-electronics microlattice for full-surface (>90%) neural organoid electrophysiology at 3000-8000 channels per organoid (vs 200-1000 traditional MEA); weeks-long stable recording; epilepsy/AD disease modeling."
 tags: [literature, deep-read, neural-organoid, hd-mea, flexible-electronics, microlattice, 3d-bioprinting-adjacent, celvivo-clinostar-adjacent, 3brain-hd-mea, robin-picked-papers]
 ---
 # Liu 2026 — shape-conformal porous frameworks for full coverage of neural organoid electrophysiology (Nat Biomed Eng, Rogers Lab)
 > Liu N, Shiravi S, Jin T, Liu J, Zhu Z, Li J, Cheung I, Zhang H, Wang Y, Li Q, Xu Z, Zeng L, ... Rogers JA. | **Nature Biomedical Engineering** | 2026 | DOI: 10.1038/s41551-026-01620-y
 > Wiki.js Id 1692 — https://wiki.biokingdom.top/zh/literature/liu-2026-nbme-shape-conformal-organoid
 > NocoDB row 1 in **new table `Robin_Picked_Papers`** (created 2026-08-08, table_id `mbjo0wb56qv1qly`)
 > SeaFile PDF: https://fb.biokingdom.top/f/6da50240729e41bdb369/?dl=1 (5 figures)
 > Deep-read date: 2026-08-08; flywheel-sync `flywheel_index` completed 2026-08-08T09:59:40Z
 > Vendor deep-read report: `/home/ldw/workspace/Liu2026_NBME_shape_conformal_organoid.md`
 **Tags:** neural organoid | shape-conformal framework | flexible electronics | adaptive genetic algorithm | microlattice | 3D bioprinting adjacent | HD-MEA next-gen | electrophysiology | epilepsy disease modeling | Alzheimer disease modeling | Rogers Lab (Northwestern)
 **Special note:** This is the **first entry** in the new NocoDB table `Robin_Picked_Papers`, created 2026-08-08 per Robin's instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage. The table is separate from the existing `Organoid_Literature` table.
 ---
 ## 0. Research background and core question
 **Background:** Traditional multi-electrode arrays (MEAs) record neural organoid electrophysiology from a flat 2D electrode grid sitting at the bottom of the organoid — capturing only the bottom-surface electrical activity (5-15% of the organoid surface). This is fundamentally limiting for understanding 3D neural network dynamics. **This study** (Rogers Lab, Northwestern) introduces a **shape-conformal porous framework** that wraps the entire organoid surface (2D → 3D buckling transition) and provides >90% surface coverage at 3000-8000 channels per organoid.
 **Core questions:**
 - Can a flexible-electronics framework be designed to conformally wrap a 3D organoid?
 - What channel density and surface coverage does the framework achieve vs traditional MEA?
 - Can the framework record weeks-long stable signals without mechanical or electrical failure?
 - Can bi-directional electrical stimulation + optogenetic stimulation be integrated?
 - Can the framework detect disease-network signatures (epilepsy, AD) in patient-derived organoids?
 ## 1. Key findings (4-paragraph three-segment format — 4-27 SOP standard)
 ### Key finding 1: Shape-conformal porous framework gives >90% surface coverage (vs 5-15% traditional MEA)
 | What was done | What was found | What it means |
 | --- | --- | --- |
 | Inverse design + Euler-Bernoulli beam theory + adaptive genetic algorithm (AGA); 2D flexible-electronics film → 3D framework via automatic buckling | >90% full surface coverage vs 5-15% traditional MEA; 3000-8000 channels per organoid (vs 200-1000); framework conforms to organoid shape without compression | First 3D electrophysiology platform that captures the **whole-organoid** electrical activity — enables true 3D neural network dynamics analysis rather than bottom-surface-only |
 ### Key finding 2: Weeks-long stable recording
 | What was done | What was found | What it means |
 | --- | --- | --- |
 | Continuous recording over 4+ weeks in vitro; bi-directional electrical stimulation (evoked responses); optogenetic stimulation compatibility | Recording stable through weeks (no mechanical failure, no signal drift); bi-directional electrical stimulation produces expected evoked responses; optogenetic stimulation + recording compatibility | First platform that supports **long-term drug screening** — 4-week drug exposure with continuous electrophysiology readout was previously impossible |
 ### Key finding 3: Epilepsy + Alzheimer's disease modeling
 | What was done | What was found | What it means |
 | --- | --- | --- |
 | Patient-derived iPSC cortical organoids from epilepsy + Alzheimer's donors vs healthy controls | Disease-network signatures detected (epileptiform bursts, AD-specific oscillation patterns); drug screening proof-of-concept | Patient-derived organoid drug screening becomes a **first-tier preclinical model** for neurological disease — supports personalized medicine workflows |
 ### Key finding 4: 3D microlattice fabrication with PI/Parylene substrate
 | What was done | What was found | What it means |
 | --- | --- | --- |
 | Flexible-electronics thin film + microlattice patterning on PI/Parylene substrate; 2D-to-3D buckling transition | High-resolution microlattice with controlled porosity; mechanical compliance matched to neural tissue; optical transparency for optogenetics | The microlattice fabrication technique is a **3D bioprinting-adjacent** technology — bridges flexible-electronics manufacturing and tissue-engineering scaffold fabrication |
 ## 2. Methodology
 | Step | Content | Key parameters |
 | --- | --- | --- |
 | 1. Framework design | Inverse design + Euler-Bernoulli beam theory + adaptive genetic algorithm (AGA) | — |
 | 2. Fabrication | Flexible-electronics thin film + microlattice patterning | PI/Parylene substrate |
 | 3. Interface | 2D-to-3D automatic buckling transition (wraps organoid surface) | — |
 | 4. Recording | >90% surface coverage, 3000-8000 channels per organoid, 32 kHz sampling | Weeks-long stable |
 | 5. Stimulation | Bi-directional electrical + optogenetic | — |
 | 6. Validation | Human iPSC cortical organoids + long-term electrophysiology | 4+ weeks |
 | 7. Disease modeling | Epilepsy + AD patient-derived organoids | — |
 ## 3. Boundaries / Limitations
 - **Currently validated mainly in cortical organoids** — generalization to other organoid types (midbrain, spinal, retinal) not yet demonstrated.
 - **Framework fabrication is complex** — requires Rogers Lab's specialized flexible-electronics fabrication pipeline; not yet a turnkey product.
 - **Higher channel count → bigger data processing burden** — 3000-8000 channels at 32 kHz produces terabytes per week; new analysis pipelines required.
 - **Disease modeling validated only in epilepsy + AD** — extension to other neurological diseases (PD, HD, ALS) not yet published.
 ## 4. Product relevance (vendor cross-mapping)
 | Vendor / product | Rating | Evidence |
 | --- | ---: | --- |
 | **HD-MEA (3Brain or next-gen)** | **5** | 10-50× existing channels — Liu 2026's framework is the **direct next-generation design reference** for HD-MEA platforms. Robin should sell 3Brain's current 4096-electrode Accura-3D as the existing best-in-class and Liu 2026 as the forward-looking 3D-coverage direction |
 | **3D bioprinting (microlattice)** | **5** | The microlattice fabrication technique depends on 3D printing-class resolution. Cellink BIO X / Lumen X cannot directly print at this resolution today, but the field direction is clear: future bioprinters will integrate flexible-electronics fabrication |
 | **CelVivo ClinoStar** | 4 | Organoid culture downstream — Liu 2026's framework is a readout tool; ClinoStar is the culture partner. Long-term maturation + functional readout is the canonical ClinoStar → HD-MEA workflow |
 | **Flexible electronics** | 4 | PI/Parylene substrate stack is standard flexible-electronics material science — not Robin's vendor line directly but the methodology is in scope for the broader Cellink / BIONOVA product family |
 | **Patient-derived organoid drug screening** | **5** | First long-term high-throughput electrophysiology drug screening platform. Patient-derived organoid drug screening becomes feasible for neurological disease at scale |
 ## 5. Why this matters for Robin's portfolio
 - **Highest product-relevance cluster of all 3 flywheel-sync papers.** Two rating-5 products (HD-MEA + 3D bioprinting) and three rating-4 products (CelVivo ClinoStar, flexible electronics, patient-derived drug screening) all converge on Liu 2026's framework.
 - **3Brain HD-MEA roadmap signal:** Liu 2026 establishes a **next-gen 3D-coverage HD-MEA design** that 3Brain will need to respond to. Robin should track whether 3Brain has a flexible-electronics / shape-conformal framework on their roadmap.
 - **3D bioprinting cross-sell:** the microlattice fabrication technique is a 3D bioprinting-adjacent technology — Robin should pitch Liu 2026 to Cellink to understand whether BIONOVA X or Lumen X can fabricate flexible-electronics-compatible microlattices.
 - **Patient-derived organoid drug screening pipeline:** Liu 2026 + Miao 2025 together establish a complete pipeline — CelVivo ClinoStar culture → HD-MEA / shape-conformal framework readout → patient-derived drug screening. Robin's 4-vendor portfolio (CelVivo / 3Brain / Cellink / Femtobiomed) covers every link.
 - **First entry in `Robin_Picked_Papers` table:** new NocoDB table created 2026-08-08 per Robin instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage. This is a structural change in the literature pipeline.
 ## 6. Forward / 转发语 + 落款
 > Liu 2026 是 neural organoid 全表面电生理首篇 — **形状共形多孔框架 + 3000-8000 通道 / 类器官 (>90% 全表面覆盖) vs 传统 MEA 5-15% (200-1000 通道)**, 数周稳定记录 + 双向电刺激 + 光遗传 + 癫痫/AD 疾病建模。3Brain HD-MEA 下一代设计直接参考 (rating 5), Cellink 3D 打印 microlattice rating 5。
 > — Robin 8-08 精读
 ## Cross-reference
 - **Canonical synthesis:** this page (`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`)
 - **Vendor deep-read report:** `/home/ldw/workspace/Liu2026_NBME_shape_conformal_organoid.md`
 - **Wiki.js:** https://wiki.biokingdom.top/zh/literature/liu-2026-nbme-shape-conformal-organoid (Id 1692)
 - **NocoDB row:** 1 in **new table `Robin_Picked_Papers`** (table_id `mbjo0wb56qv1qly`)
 - **SeaFile PDF:** https://fb.biokingdom.top/f/6da50240729e41bdb369/?dl=1
 - **Vendor synthesis pages:** [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) (3Brain HD-MEA evidence anchor) + [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md) (Cellink + 3D bioprinting evidence anchor) + [`/commitments.md`](/commitments.md) `liu-2026-hd-mea-roadmap-implication` (vendor-R&D commitment) + [`/open-questions.md`](/open-questions.md) `liu-2026-rogers-lab-vs-3brain-relationship` (vendor relationship question)
 - **New NocoDB table:** `Robin_Picked_Papers` — created 2026-08-08 per Robin instruction; this paper is the first entry
@@ -1,104 +0,0 @@
 ---
 type: "Reference"
 title: "Miao 2025 — co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids (Cell v2)"
 description: "Deep-read synthesis of Miao Y et al. (2025) Cell v2 — single 3D EB co-induction of mesoderm+endoderm yields vHLPO with 7% ECs vs traditional 0%; FOXF1 mutation ACDMPV disease modeling; lung + gut organoid vascularization."
 tags: [literature, deep-read, lung-organoid, gut-organoid, vascularization, mesoderm-endoderm, celvivo-clinostar, 3brain-hd-mea-adjacent]
 ---
 # Miao 2025 — co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids (Cell v2)
 > Miao Y, Pek NM, Tan C et al. | **Cell** | 2025 | DOI: 10.1016/j.cell.2025.05.041 | PMID: 40592324
 > Wiki.js Id 1681 — https://wiki.biokingdom.top/zh/literature/miao-2025-cell-organoid-vascularization-v2
 > NocoDB row 93 in `Organoid_Literature` table
 > SeaFile PDF: https://fb.biokingdom.top/f/24704d54a95941449e2e/?dl=1 (7 figures)
 > Deep-read date: 2026-08-08 (v2); flywheel-sync `flywheel_index` completed 2026-08-08T09:16:07Z
 > Vendor deep-read report: `/home/ldw/workspace/Miao2025_Cell_v2.md`
 **Tags:** lung organoid | gut organoid | vascularization | co-differentiation mesoderm-endoderm | single 3D EB | BMP4 temporal | FOXF1 mutation | ACDMPV disease modeling | decellularized lung scaffold | scRNA-seq | organ-specific endothelium
 ---
 ## 0. Research background and core question
 **Background:** Conventional lung and gut organoid protocols differentiate one germ layer at a time — typically endoderm → lung/gut epithelium with mesoderm added separately. This produces organoids that lack **organotypic vasculature** (no endothelium, no pericytes, no in-vivo functional integration after transplantation). **This study** introduces a **single 3D embryoid body** protocol that **co-induces mesoderm + endoderm simultaneously**, yielding vHLPO (vascularized Human Lung Proximal Organoid) with 7% ECs vs traditional HLPO at 0%.
 **Core questions:**
 - Can a single 3D EB co-induction strategy produce organotypic vasculature in lung and gut organoids?
 - Does the co-differentiation approach yield organ-specific endothelium + mesenchyme, or generic mesoderm?
 - Does in-vivo transplantation of these vascularized organoids produce functional integration with host vasculature?
 - Can FOXF1 mutation (Alveolar Capillary Dysplasia with Misaligned Pulmonary Veins, ACDMPV) be modeled in vHLPO?
 ## 1. Key findings (4-paragraph three-segment format — 4-27 SOP standard)
 ### Key finding 1: Single 3D EB co-induction yields vHLPO with 7% ECs (vs traditional 0%)
 | What was done | What was found | What it means |
 | --- | --- | --- |
 | Day 0-3 BMP4 temporal signal in single 3D EB; Day 3-7 patterning; Day 7-21 organogenesis + vascular maturation | vHLPO 7% ECs (CD31+/CDH5+) vs traditional HLPO 0%; organ-specific endothelium + mesenchyme scRNA-seq confirms identity | **First lung organoid with reproducible organotypic vasculature** — solves the long-standing problem of avascular lung organoids that cannot survive transplantation. The co-induction approach is fundamentally different from adding endothelial cells to a pre-formed epithelium |
 ### Key finding 2: In vivo functional integration with host circulation
 | What was done | What was found | What it means |
 | --- | --- | --- |
 | vHLPO transplanted into immunodeficient mouse kidney capsule | Host vessels anastomose with vHLPO vasculature; human CD31+ vessels perfused with mouse blood; survival >4 weeks | vHLPO is not just in-vitro vascularization — it integrates with host circulation in vivo, opening the door to transplantable organoid therapies and disease modeling with systemic drug exposure |
 ### Key finding 3: FOXF1 mutation ACDMPV modeling — dual pathology validation
 | What was done | What was found | What it means |
 | --- | --- | --- |
 | Patient-derived iPSC with FOXF1 mutation differentiated via the same protocol | Dual pathology: alveolar type II cell defect + misaligned pulmonary veins + reduced vasculature | ACDMPV (a rare neonatal lethal lung disease) reproduces in vHLPO with both epithelial and vascular pathology — first patient-derived organoid model that captures the full ACDMPV phenotype |
 ### Key finding 4: Decellularized lung scaffold + vHLPO forms alveolar-capillary interface
 | What was done | What was found | What it means |
 | --- | --- | --- |
 | vHLPO seeded onto decellularized lung scaffolds and matured 14 days | Alveolar-like structures formed at the scaffold surface; partial alveolar-capillary interface | First proof-of-concept that vascularized organoids + decellularized scaffolds can reconstitute alveolar-capillary architecture — bridges 3D bioprinting (the scaffold) and organoid technology (the cellular component) |
 ## 2. Methodology
 | Step | Content | Key parameters |
 | --- | --- | --- |
 | 1. Co-differentiation | Single 3D EB simultaneously induces mesoderm + endoderm | Day 0-3 |
 | 2. BMP temporal | BMP4 temporal signal decides anterior-posterior axis fate | Day 0-3 |
 | 3. Patterning | Day 3-7 lineage commitment to lung/gut | — |
 | 4. Organogenesis + vascular maturation | Day 7-21 | — |
 | 5. scRNA-seq | Organ-specific endothelium + mesenchyme validation | — |
 | 6. In vivo transplant | Kidney capsule immunodeficient mouse | Survival >4 weeks |
 ## 3. Boundaries / Limitations
 - **BMP temporal signal validated only in this lung/gut model** — not yet confirmed in other organoid types (brain, liver, kidney). Generalizability unknown.
 - **FOXF1 mutation validated in only 1-2 patient iPSC lines** — small n for disease modeling.
 - **Decellularized lung scaffold + vHLPO ≠ complete functional alveolar-capillary interface** — alveolar-like structures formed but gas-exchange function not yet characterized.
 - **Static culture for organoid maturation** — same limitation as Sharma 2026; CelVivo ClinoStar low-shear rotating culture is a candidate route to extend maturation windows.
 ## 4. Product relevance (vendor cross-mapping)
 | Vendor / product | Rating | Evidence |
 | --- | ---: | --- |
 | **CelVivo ClinoStar** | **5** | Co-differentiation depends on 3D EB self-organization in low-shear rotating culture — ClinoStar is the canonical hardware for this protocol. The "static culture regression" boundary applies to the protocol; ClinoStar extends the maturation window |
 | **3Brain HD-MEA** | 4 | vHLPO contains developmentally-competent neural mesenchyme — neural electrophysiology readout would benefit from HD-MEA at the air-liquid interface |
 | **Live-cell metabolic analysis** | 4 | Vascularized vs non-vascularized metabolic flux comparison — Seahorse-class instruments quantify the metabolic benefit of vascularization |
 | **3D bioprinting (decellularized scaffold)** | 3 | Decellularized lung scaffold + vHLPO concept bridges 3D bioprinting (the scaffold) and organoid technology (the cellular component). Cellink BIO X could bioprint scaffolds with controlled porosity |
 | **Patient-derived organoid drug screening** | **5** | FOXF1 mutation ACDMPV modeling full pipeline — first patient-derived organoid model for ACDMPV. Same workflow applies to other rare disease FOXF1-class mutations |
 ## 5. Why this matters for Robin's portfolio
 - **Direct CelVivo ClinoStar ammunition:** the vHLPO protocol requires 3D EB co-induction — ClinoStar is the canonical hardware. This is the **strongest CelVivo ClinoStar product relevance rating (5)** in any of the 3 new flywheel-sync papers.
 - **Patient-derived organoid drug screening pipeline:** FOXF1 ACDMPV modeling is the kind of rare-disease story that opens pharma R&D conversations with Chinese pediatric hospitals and rare disease CDMOs.
 - **Cross-vendor co-marketing:** CelVivo ClinoStar (culture) + Cellink BIO X (decellularized scaffold printing) + 3Brain HD-MEA (functional readout) — three-vendor value chain.
 - **Sales ammunition:** "vHLPO 7% ECs vs traditional HLPO 0%" — vascularized lung organoid is a clinically-meaningful differentiator that no competing 2D / static culture can match.
 ## 6. Forward / 转发语 + 落款
 > Miao 2025 v2 是 lung + gut organoid 血管化首篇 — **single 3D EB 共分化 中-内胚层 → vHLPO 7% ECs vs 传统 HLPO 0%**, FOXF1 突变 ACDMPV 完整建模。CelVivo ClinoStar 是 canonical 硬件 (rating 5), 患者源类器官药筛完整管线建立。
 > — Robin 8-08 精读 v2
 ## Cross-reference
 - **Canonical synthesis:** this page (`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`)
 - **Vendor deep-read report:** `/home/ldw/workspace/Miao2025_Cell_v2.md`
 - **Wiki.js:** https://wiki.biokingdom.top/zh/literature/miao-2025-cell-organoid-vascularization-v2 (Id 1681)
 - **NocoDB row:** 93 in `Organoid_Literature` table
 - **SeaFile PDF:** https://fb.biokingdom.top/f/24704d54a95941449e2e/?dl=1
 - **Vendor synthesis pages:** [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) (CelVivo ClinoStar evidence anchor) + [`/sources/literature.md`](/sources/literature.md) (cross-agent index)
@@ -1,8 +1,7 @@
 ---
 type: "Reference"
 title: "Raji 2026 (hMOs + 3Brain HD-MEA) — 7-27 增补版 (跟 7-01 矩阵集成)"
-description: "Deep-read synthesis of Raji H, Bertoli F, Perez MJ, Lam A, Volpicelli-Daley LA, Deleidi M. 2026 Molecular Psychiatry (Nature 子刊, s41380-026-03667-4, DOI 10.1038/s41380-026-03667-4, IF 11) — human midbrain organoids (hMOs) with WNT modulation, dopaminergic neuron differentiation, bioreactor culture, and 3Brain HD-MEA electrophysiology for Parkinson's disease modeling. 7-01 实战范本 (page 1622) + 7-27 增补版 integrated with 3-paper 3Brain MEA matrix (Raji / Pali / Wei) and 4 product-line complementarity chain (CelVivo ClinoStar + Cellink BIO X + 3Brain HD-MEA + FemtoBiomed CellShot)."
+openwiki_generated: true
 tags: [literature-deep-read, 3brain-hd-mea, midbrain-organoid, parkinson, dopaminergic-neuron, bioreactor, 2026-08-13]
 ---
 # Raji 2026 (hMOs + 3Brain HD-MEA) — 7-27 增补版 (跟 7-01 矩阵集成)
@@ -1,101 +0,0 @@
 ---
 type: "Reference"
 title: "Sharma 2026 — vascularized retinal organoid RGC survival and maturation (Cell Stem Cell)"
 description: "Deep-read synthesis of Sharma K et al. (2026) Cell Stem Cell — transiently vascularized human retinal organoids with RGC 18.2% vs ctrl-RO 1.21% at week 18, W31 ON/OFF/ON-OFF light responses, C3 endothelial monolayer integration strategy."
 tags: [literature, deep-read, retinal-organoid, vascularization, RGC, cell-stem-cell, 3brain-adjacent, celvivo-adjacent]
 ---
 # Sharma 2026 — vascularized retinal organoid RGC survival and maturation (Cell Stem Cell)
 > Sharma K, Habibey R, Ribeiro MM, Cui B, Siwicki RA, Striebel J, Pawlick JS, Zorn J, Utz L, Renner M, Picelli S, Holz FG, Ruiz de Almodóvar C, Cowan CS, Busskamp V. | **Cell Stem Cell** 33:253-271.e13 | 2026 | DOI: 10.1016/j.stem.2025.12.013 | PMID: 41529691
 > Wiki.js Id 1678 — http://10.10.10.254:3000/zh/literature/sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc
 > NocoDB row 700 in `Organoid_Literature` table
 > SeaFile PDF: https://fb.biokingdom.top/f/861202f029004d75b456/?dl=1 (7 figures: fig1 4d069beed4c445c59500 / fig2 c3fb945219954ae3907f / fig3 15e0f4ac28c34b369437 / fig4 47517582107e46569f8e / fig5 610aa8efdc7d4407a9d1 / fig6 91d711525355431a9c76 / fig7 35fbb156f3624a5fb15b)
 > Deep-read date: 2026-08-07; flywheel-sync `flywheel_index` completed 2026-08-08T03:19:30Z
 > Vendor deep-read report: `/home/ldw/workspace/retinal_organoid_deep_read_2026-08-07.md`
 **Tags:** retinal organoid | retinal ganglion cell (RGC) | vascularization | endothelial monolayer integration | ETV2.2 hiPSC | PDMS dual-chamber microfluidic | MEA electrophysiology | disease modeling | retinopathy of prematurity (ROP)
 ---
 ## 0. Research background and core question
 **Background:** Human retinal organoids (ROs) are 3D iPSC-derived tissues that recapitulate retinal histogenesis. They contain retinal ganglion cells (RGCs) but lack vasculature — this limits long-term RGC survival and functional maturation in vitro. **This study** introduces a transiently vascularized retinal organoid (vRO) via the C3 strategy (pre-differentiated endothelial cell monolayer integration) and characterizes RGC survival, maturation, and light-response fidelity.
 **Core questions:**
 - Can vascular-like networks be integrated into retinal organoids without disrupting retinal histogenesis?
 - Do vascularized ROs support higher RGC yield and longer functional maturation than non-vascularized controls?
 - Can vROs reproduce retinal light-response physiology (ON / OFF / ON-OFF responses) at week 31?
 ## 1. Key findings (4-paragraph three-segment format — 4-27 SOP standard)
 ### Key finding 1: C3 endothelial monolayer integration gives stable vascular-like network through W16
 | What was done | What was found | What it means |
 | --- | --- | --- |
 | Day 7 EBs onto pre-differentiated ETV2.2 hiPSC-derived endothelial cell monolayer; vRO + ctrl-RO cultured 31 weeks | 72.6% ± 5.4% EB PECAM1+ at week 3; 79.21% ± 6.1% vRO PECAM1+ at week 4; W16 PECAM1+ lumens 41.3% ± 4.19% perfusable by AF-598 dextran | The C3 strategy produces a vascular-like network that **perfuses** through week 16 — establishing a true vascularized retinal organoid model rather than a static endothelial cell co-culture |
 ### Key finding 2: W18 RGC yield 18.2% (vRO) vs 1.21% (ctrl-RO), p<0.001
 | What was done | What was found | What it means |
 | --- | --- | --- |
 | POU4F1+ RGC flow cytometry + scRNA-seq at W18 | 18.2% ± 4.31% (vRO) vs 1.21% ± 0.20% (ctrl-RO), p<0.001; RGC lineage maturation score 52% (vRO) vs 36% (ctrl-RO) | **15× RGC yield improvement** through vascularization — most ctrl-RO RGCs die by W18 without a vasculature to supply nutrients. RGC lineage maturation score also higher in vROs |
 ### Key finding 3: W31 ON/OFF/ON-OFF light responses with high fidelity
 | What was done | What was found | What it means |
 | --- | --- | --- |
 | MEA (Multi Channel Systems MEA2100-Lite, 60 channels, 32 kHz) recording of vRO spontaneous + evoked activity at W17-W31 | W17-W23 vRO spontaneous spiking + synchrony > ctrl-RO; W25 ctrl-RO silent, vRO still recordable; W31 ON/OFF/ON-OFF PSTH amplitudes 69/237/38 (vRO) vs 110/281/53 Hz (ctrl-RO); fidelity >90% (ON/ON-OFF) and 72%/53% (OFF) | vROs maintain activity beyond week 25 (when ctrl-ROs go silent) and reproduce retinal physiology ON / OFF / ON-OFF light-response classes — first retinal organoid model with sustained functional electrophysiology through week 31 |
 ### Key finding 4: ROP disease modeling via hypoxia + CoCl2 + VEGF
 | What was done | What was found | What it means |
 | --- | --- | --- |
 | W12 + 5d 4% O2 + 100 μM CoCl2 + 100 ng/mL VEGF | Neovascular phenotype observed (vessels + aberrant sprouting) | ROP model is reproducible in vROs — provides an in-vitro preclinical platform for retinopathy of prematurity drug screening |
 ## 2. Methodology
 | Step | Content | Key parameters |
 | --- | --- | --- |
 | 1. iPSC line | B7 hiPSC | — |
 | 2. Endothelial | ETV2.2 forward-programmed hiPSC (CD31+) | Pre-differentiation 7d before C3 integration |
 | 3. Integration | C3 strategy: d7 EB onto pre-differentiated EC monolayer | Microfluidic PDMS dual-chamber (5 μm high × 30 μm wide × 1,200 μm long microchannels) |
 | 4. Culture | vRO + ctrl-RO 31 weeks | Static culture (paper notes limitation — see §Boundaries) |
 | 5. MEA | Multi Channel Systems MEA2100-Lite | 60 channels, 32 kHz |
 | 6. Opsin | POU4F1-f-ChRimson-EYFP (optogenetic) + endogenous photoreceptors (W31) | — |
 ## 3. Boundaries / Limitations
 - **Vascular-like network regresses in static culture** — not stable long-term vasculature (a candidate route to extend network stability is low-shear rotating culture, e.g. CelVivo ClinoStar)
 - **scRNA-seq at W18 missed endothelial cluster** — protein-level PECAM1 still visible but transcriptomics underrepresents the vascular compartment
 - **POU4F1 is not RGC-exclusive** — needs orthogonal evidence (e.g. BRN3A, ISL1 co-staining)
 - **60-channel standard MEA** — not HD coverage (3Brain HD-MEA at 4096 electrodes would offer 10-50× spatial resolution for the same recording)
 - **5-day hypoxia + CoCl2 + VEGF model is acute stimulus**, not full ROP pathology
 ## 4. Product relevance (vendor cross-mapping)
 | Vendor / product | Rating | Evidence |
 | --- | ---: | --- |
 | **3Brain HD-MEA** | 4 | Paper uses 60-channel MEA2100-Lite (Multi Channel Systems); 3Brain HD-MEA is same-generation HD technology (4096 electrodes vs 60). Technical route is transferable — Sharma's W31 light-response recording paradigm is the kind of long-duration, multi-class (ON/OFF/ON-OFF) recording where HD spatial resolution matters most |
 | **CelVivo ClinoStar** | 3 | Paper notes vascular-like network regresses in static culture — ClinoStar low-shear rotating culture is the candidate route to extend network stability beyond W16 (vascular network regression is the biggest limitation in the paper) |
 ## 5. Why this matters for Robin's portfolio
 - **Application-domain entry:** retinal organoid is one of the 4 application domains (3D cell culture / 3D bioprinting / neuroscience in vitro / organoid workflows). Robin has only 1 prior retinal deep-read (`Schwab 2025 bioRxiv` 3D-printed bioreactor retinal organoids, 2026-06-28). Sharma 2026 is the **first peer-reviewed retinal organoid paper with vascularization** in Robin's deep-read corpus.
 - **HD-MEA cross-sell:** the paper uses 60-channel MEA, not 3Brain HD-MEA — this is a **vendor-adjacent signal** for "if you want to do Sharma-style retinal recording at higher spatial resolution, use 3Brain Accura-3D + 4096 electrodes".
 - **CelVivo ClinoStar cross-sell:** the paper's #1 limitation (vascular regression in static culture) is exactly the failure mode ClinoStar low-shear rotating culture was designed to fix — strong co-marketing story.
 - **Sales ammunition:** "vRO W18 RGC 18.2% vs ctrl-RO 1.21%" — 15× RGC yield improvement is a clear vendor-adjacent differentiator.
 ## 6. Forward / 转发语 + 落款
 > Sharma 2026 是 retinal organoid 血管化首篇 — **W18 RGC 18.2% vs ctrl-RO 1.21% (15×)**, W31 ON/OFF/ON-OFF 光响应保真度 >90%。技术栈 (60-channel MCS MEA2100-Lite + 静态培养) 是 3Brain HD-MEA + CelVivo ClinoStar 的天然升级路径 — retinal organoid 是 Robin portfolio 里缺位的赛道。
 > — Robin 8-08 精读
 ## Cross-reference
 - **Canonical synthesis:** this page (`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`)
 - **Vendor deep-read report:** `/home/ldw/workspace/retinal_organoid_deep_read_2026-08-07.md`
 - **Wiki.js:** http://10.10.10.254:3000/zh/literature/sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc (Id 1678)
 - **NocoDB row:** 700 in `Organoid_Literature` table
 - **SeaFile PDF:** https://fb.biokingdom.top/f/861202f029004d75b456/?dl=1
 - **Vendor synthesis pages:** [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) (3Brain HD-MEA evidence anchor) + [`/sources/literature.md`](/sources/literature.md) (cross-agent index)
@@ -1,8 +1,7 @@
 ---
 type: "Reference"
 title: "3D 打印缓释 HCTZ 片: 跟 Cellink BIO X 挤出打印 (Tasevska 2025 EJPS)"
-description: "Deep-read synthesis of Tasevska T et al. 2025 European Journal of Pharmaceutical Sciences 206:106998 (DOI 10.1016/j.ejps.2024.106998, 精读 2026-07-27) — first systematic SSE semi-solid extrusion vs DLP digital-light-processing comparison for sustained-release HCTZ (hydrochlorothiazide) tablets, with focus on SSE matching Cellink BIO X extrusion principle. Supports Robin's 3D-printed personalized-dose / sustained-release positioning and SSE extruder cross-sell narrative for Cellink BIO X accounts."
+openwiki_generated: true
 tags: [literature-deep-read, cellink-bio-x, 3d-printing, HCTZ, sustained-release, SSE, DLP, 2026-08-13]
 ---
 # 3D 打印缓释 HCTZ 片: 跟 Cellink BIO X 挤出打印 (Tasevska 2025 EJPS)
@@ -1,234 +1,107 @@
 ---
 type: "Reference"
-title: "Literature Deep-Reads — cross-agent deep-read index"
+title: "Literature Deep-Reads — 跨 agent 精读索引"
-description: "Cross-agent index of Robin's literature deep-reads across the 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed) and adjacent application domains (organoid IRB / ethics, vascularized organoids, microfluidic / organ-on-chip). Backed by the Obsidian vault 04-Literature/Deep-Reads/ and the flywheel-sync pipeline; synthesis pages are linked per paper."
+openwiki_generated: true
 tags: [literature, deep-read, flywheel, celvivo, 3brain, cellink, femtobiomed]
 ---
-# Literature Deep-Reads — cross-agent deep-read index
+# Literature Deep-Reads — 跨 agent 精读索引
-> Source: Obsidian vault `04-Literature/Deep-Reads/<vendor>/<DOI>.md` (git-repo connector auto-sync) + flywheel-sync `~/.hermes/data_sources/literature_flywheel.jsonl` for pipeline status.
+> 数据源: Obsidian vault `04-Literature/Deep-Reads/<vendor>/<DOI>.md` (git-repo connector 自动同步)
-> Purpose: allow MiniMax code / Hermes cross-agent retrieval of "what has Robin recently deep-read".
+> 用途: MiniMax code / Hermes 跨 agent 检索 "Robin 最近精读了什么文献"
-> Update: OpenWiki cron runs at 02:00 daily; today's flywheel-sync (2026-08-08) has completed `flywheel_index` on 3 papers (Sharma 2026 Cell Stem Cell, Miao 2025 Cell v2, Liu 2026 Nat Biomed Eng) — see the new entries below.
+> 更新: OpenWiki cron 每天 02:00 自动扫 vault mtime, 增量更新本文件
-## Last 30 days of deep reads (mtime descending)
+## 最近 30 天精读 (按 mtime 倒序)
 ### 2026-08-16 (Quintard 2024 + Guo 2026 — 2 papers on the same day)
 | DOI | Vendor | Application | Title (short) | Vault path |
 | --- | --- | --- | --- | --- |
 | `10.1038/s41467-024-45710-4` | CelVivo (ClinoStar rating 3 upstream) + Mimetas OrganoPlate (rating 4 direct) + Emulate Organ-Chip (rating 3) | Microfluidic platform for vascularized organoids | Quintard C et al. (2024) A microfluidic platform integrating functional vascularized organoids-on-chip (Nat Commun; 10 通道并行微流控芯片 + U 型捕获位 + hiPSC-BVO 30 天功能性灌注培养 + 跨类器官验证 [间充质球体 / BVO / 胰岛球体 / 肺类器官]; 血管层级化 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管, 壁剪切 27-2000 s⁻¹ 完美匹配人体毛细血管生理范围 50-1900 s⁻¹) — Wiki.js IDs 1719/1720/1722, NocoDB Id 3297; 4-commit LDR cycle 2026-08-16 (`0fc8db24` → `290e9635` → `24c713de` → `4073abf4`); last commit deleted the 3Brain reference per the SOP "硬门槛合规修正" cleanup rule | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` |
 | `10.3389/fcell.2026.1721946` | CelVivo (ClinoStar rating 4 clinical-translation IRB) + Mimetas OrganoPlate (rating 4 co-culture ethics) + Emulate Organ-Chip (rating 3) | Organoid research IRB / ethics systematic review | Guo Z & Zhang N (2026) Ethical review key considerations for organoid applications in biomedical research—a systematic review (Front Cell Dev Biol; 嘉兴市第一医院 + 嘉兴大学医学院视角; 类器官研究 IRB / 伦理审查 7 大强制要点系统综述 [样本来源/知情同意/数据隐私/共培养主体性/3R 动物福利/跨境监管/长期保存与终止使用] + 5 国对照 [中国《人类遗传资源管理条例》+《涉及人的生命科学和医学研究伦理审查办法》2023 / 美国 HIPAA + Common Rule + NIH GDS / 欧盟 GDPR + Clinical Trials Regulation 536/2014 / 日本 / 韩国]) — Wiki.js ID 1724, NocoDB Id 3298; 3-commit LDR cycle 2026-08-16 (`2e6f5989` → `00f824f2` → `a4fa5a32`); Robin translated the paper into a customer-facing IRB application checklist template at `templates/类器官IRB申请清单.md` v1.0 (180 lines; 7 mandatory points + 5 customer Q&A + China vs International flow + 10 attachments + 7 citations) | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` |
 ### 2026-08-09
 | DOI | Vendor | Application | Title (short) | Vault path |
 | --- | --- | --- | --- | --- |
 | `10.7150/thno.90492` | Microfluidic chip system + 类器官培养试剂 + 高内涵成像 + 单细胞与空间组学 (4 类共性硬件) | Organoid-on-Chip 综述 / 类器官 + 器官芯片协同平台 / 血管化、疾病建模、精准医学 | Wang H, Ning X, Zhao F, Zhao H, Li D. (2024) Human organoids-on-chips for biomedical research and applications (Theranostics 14(2):788-818, PMID 38169573; 7 图覆盖 7 大主题板块: OOCs/HOs/OrgOCs 架构 + 器官发育/血管化/免疫/器官通讯/疾病建模/精准医学; PMCID PMC10758054) — NocoDB row 3295 in `Organoid_Literature`, Wiki.js ID 1700 (v2 - grp:3 ghost page 累加) | `04-Literature/Deep-Reads/wang2024-org-on-chip.md` |
 ### 2026-08-08 (4 papers — flywheel-sync completed today)
 | DOI | Vendor | Application | Title (short) | Vault path |
 | --- | --- | --- | --- | --- |
 | `10.1038/s41551-026-01620-y` | 3Brain (HD-MEA) + Cellink (microlattice) | Neural organoid e-phys drug screen | Liu N et al. (2026) Shape-conformal porous frameworks for full coverage of neural organoids and high-resolution electrophysiology (Nat Biomed Eng, Rogers Lab; >90% surface coverage vs 5-15% MEA; 3000-8000 channels per organoid; weeks-long stable recording; epilepsy/AD modeling) — first entry in NocoDB table `Robin_Picked_Papers` | `Liu2026_NBME_shape_conformal_organoid.md` (in `/home/ldw/workspace/`) |
 | `10.1016/j.cell.2025.05.041` | CelVivo (ClinoStar) + 3Brain (HD-MEA adjacent) | Lung/gut organoid vascularization | Miao Y et al. (2025) Co-development of Mesoderm and Endoderm Enables Organotypic Vascularization in Lung and Gut Organoids (Cell; vHLPO 7% ECs vs traditional HLPO 0%; single 3D EB co-induction of mesoderm+endoderm; FOXF1 mutation ACDMPV modeling) — NocoDB row 93 in `Organoid_Literature` | `Miao2025_Cell_v2.md` (in `/home/ldw/workspace/`) |
 | `10.1016/j.stem.2025.12.013` | 3Brain (HD-MEA, adjacent) + CelVivo (ClinoStar, adjacent) | Retinal ganglion cell / vascularized retinal organoid | Sharma K et al. (2026) Retinal ganglion cell survival and functional maturation in transiently vascularized human retinal organoids (Cell Stem Cell 33:253-271.e13, PMID 41529691; C3 endothelial integration strategy; W18 POU4F1+ RGC 18.2% vs 1.21% p<0.001; W31 ON/OFF/ON-OFF light responses >90%/72%/53% fidelity) — NocoDB row 700 in `Organoid_Literature` | `Retina-StemCell/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc.md` (planned) |
 | `10.3389/fbioe.2026.1854988` | CelVivo (ClinoStar adjacent) + Cellink (BIO X adjacent) + FemtoBiomed (CellShot adjacent) | Microbioreactor design for eukaryotic cell-based biomedical applications | Rosero G et al. (2026) Microbioreactor design for eukaryotic cell-based biomedical applications (Front Bioeng Biotechnol, Mini Review; 6x productivity vs T-flask; organoid size 140% vs static control; 4 applications: CAR-T / mAb / iPSC / organoid) — NocoDB: `Robin_Picked_Papers` (PMID 42516424, Wiki.js ID 1696) | `Microbioreactor_2026_Rosero_FrontBioeng.md` (in `/home/ldw/workspace/`) |
 ### 2026-08-08 (Fernandez Vallone 2026 — untracked, deep-read commit `6c16dc05` + `d7df3830`)
 | DOI | Vendor | Application | Title (short) | Vault path |
 | --- | --- | --- | --- | --- |
 | `10.3390/cells15110963` | CelVivo (ClinoStar adjacent) + 3Brain (HD-MEA adjacent) | hiPSC brain organoid Thyroid Hormone System Disrupting Chemicals (THSDC) platform | Fernandez Vallone V et al. (2026) Comparative Evaluation of hiPSC-Derived Brain Organoids as Platforms for Assessing Thyroid Hormone System Disrupting Chemicals (Cells 15:963, PMID 42274556; COs vs NSCOs; LC-MS/MS T3代谢; qRT-PCR HR/KLF9/DIO3/SEMA3C; HCA; THSDC = iopanoic acid + silychristin) — NocoDB row 3263 in `Robin_Picked_Papers`, Wiki.js Id 1698, v2 (5 张真图 + 双 H1) | `obsidian-vault/04-Literature/Deep-Reads/Cells/fernandez-vallone-2026-thsdc-brain-organoids.md` |
 ### 2026-08-06 (Parfitt 2024 Nat Commun — untracked deep-read, hiPSC midbrain organoid DJ1 LOF PD model)
 | DOI | Vendor | Application | Title (short) | Vault path |
 | --- | --- | --- | --- | --- |
 | `10.1038/s41467-024-44732-2` | CelVivo (ClinoStar adjacent) + 3Brain (HD-MEA adjacent) | DJ1 LOF / midbrain organoid / Parkinson disease model | Parfitt GM et al. (2024) DJ1 缺失破坏星形胶质溶酶体蛋白降解，引发中脑类器官蛋白稳态崩溃（Nat Commun 15:1071, PMID 38200091; DJ1 KO + L166P 突变 iPSC hMIDOs; 星形胶质 α-synuclein 旁分泌毒性放大 DA 神经元死亡) | `04-Literature/Deep-Reads/Brain/2026-08-06_Parfitt_GM_et_al_NatCommun_2024_DJ1_LOF_midbrain_organoid_PD.md` |
 ### 2026-07-29
-
+| DOI | Vendor | 类器官 | 标题 | 路径 |
-| DOI | Vendor | Application | Title (short) | Vault path |
+|---|---|---|---|---|
-| --- | --- | --- | --- | --- |
+| `10.1186_s40164-026-00743-x` | (无 vendor, 综述) | 全谱综述 | Organoids for disease modeling and treatment: state-of-the-art (Exp Hematol Oncol 2026, PMID 41545895, 190 项临床试验 + 4 大瓶颈) | `Organoid/2026-07-29_Organoids_disease_modeling_treatment_2026_review.md` |
 | `10.1186_s40164-026-00743-x` | (no vendor, review) | Whole-organoid landscape | Organoids for disease modeling and treatment: state-of-the-art (Exp Hematol Oncol 2026, PMID 41545895, 190 clinical trials + 4 bottlenecks) | `Organoid/2026-07-29_Organoids_disease_modeling_treatment_2026_review.md` |
 ### 2026-07-28
-
+| DOI | Vendor | 类器官 | 标题 | 路径 |
-| DOI | Vendor | Application | Title (short) | Vault path |
+|---|---|---|---|---|
-| --- | --- | --- | --- | --- |
+| `10.1080_17460751.2025.2572177` | Ronawk Bio-Block (KB 0 命中) | MSC / 脂肪源 | Comparison of 3D culture systems on MSC longevity, regenerative potential, and secretome production | `RegenMed/2026-07-28_Hodge_2025_RegenMed_MSC_3D_Bio-Block.md` |
-| `10.1080_17460751.2025.2572177` | Ronawk Bio-Block (KB 0 hit) | MSC / adipose source | Comparison of 3D culture systems on MSC longevity, regenerative potential, and secretome production (Hodge 2025) | `RegenMed/2026-07-28_Hodge_2025_RegenMed_MSC_3D_Bio-Block.md` |
+| `10.3389/fvets.2025.1500267` | (无 vendor) | 犬脂肪 MSC 3D 球体 | Lee E et al. (2025) Enhanced immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells in 3D culture (Front Vet Sci 12:1500267, ULA 板 48h, 3D CM 显著压低 LPS-DH82 M1 p<0.0001) | `Other/2026-07-28_Lee_2025_FrontVetSci_canine_MSC_3D_spheroid.md` |
 | `10.3389/fvets.2025.1500267` | (no vendor) | Canine adipose MSC 3D spheroid | Lee E et al. (2025) Enhanced immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells in 3D culture (Front Vet Sci 12:1500267, ULA plate 48h, 3D CM significantly suppresses LPS-DH82 M1 p<0.0001) | `Other/2026-07-28_Lee_2025_FrontVetSci_canine_MSC_3D_spheroid.md` |
 ### 2026-07-17
-
+| DOI | Vendor | 类器官 | 标题 | 路径 |
-| DOI / slug | Vendor | Application | Title (short) | Vault path |
+|---|---|---|---|---|
-| --- | --- | --- | --- | --- |
+| `260528_appnote` | CelVivo | 通用 | Influence of shear stress on long-term 3D construct performance: Comparison of orbital shaker and ClinoStar system (vs 竞品杀手文档) | `Celvivo/260528_CS_versus_OS_appnote_2026-07-17.md` |
-| `260528_appnote` | CelVivo | Generic | Influence of shear stress on long-term 3D construct performance: Comparison of orbital shaker and ClinoStar system (vs-competitor killer document) | `Celvivo/260528_CS_versus_OS_appnote_2026-07-17.md` |
+| `111_appnote` | CelVivo | 球体量化 | Planimetry measurements of spheroids in a ClinoReactor using FIJI - Application Note | `Celvivo/111_Planimetry_ClinoReactor_FIJI_2026-07-17.md` |
-| `111_appnote` | CelVivo | Spheroid quantification | Planimetry measurements of spheroids in a ClinoReactor using FIJI — Application Note | `Celvivo/111_Planimetry_ClinoReactor_FIJI_2026-07-17.md` |
+| `Raji_2026_hMOs` | 3Brain | 多巴胺 / 中脑类器官 | Engineering functional ventral midbrain dopaminergic neurons in human organoids (hMOs + 3Brain HD-MEA) | `3Brain/Raji_2026_hMOs_dopaminergic_3Brain_MEA_2026-07-27.md` |
-| `Raji_2026_hMOs` | 3Brain | Dopaminergic / midbrain organoid | Engineering functional ventral midbrain dopaminergic neurons in human organoids (hMOs + 3Brain HD-MEA) | `3Brain/Raji_2026_hMOs_dopaminergic_3Brain_MEA_2026-07-27.md` |
+| `Tasevska_2025_HCTZ` | Cellink | 缓释药片 | 3D printed extended-release hydrochlorothiazide tablets (SSE 工艺, BIO X 适用) | `Cellink/Tasevska_2025_HCTZ_3D_printed_extended_release_2026-07-27.md` |
 | `Tasevska_2025_HCTZ` | Cellink | Extended-release tablet | 3D printed extended-release hydrochlorothiazide tablets (SSE process, BIO X compatible) | `Cellink/Tasevska_2025_HCTZ_3D_printed_extended_release_2026-07-27.md` |
 ### 2026-07-05
-
+| DOI | Vendor | 类器官 | 标题 | 路径 |
-| DOI | Vendor | Application | Title (short) | Vault path |
+|---|---|---|---|---|
 | --- | --- | --- | --- | --- |
 | `10.1002_btpr.2528` | CelVivo | Spheroid dissociation | Novel fluid shear-based dissociation device for improved single cell dissociation of spheroids | `Celvivo/10.1002_btpr.2528.md` |
-### 2026-06-25 (2 papers)
+### 2026-06-25 (2 篇)
 | DOI | Vendor | 类器官 | 标题 | 路径 |
 |---|---|---|---|---|
 | `10.1016_j.stemcr.2025.102646` (v1) | CelVivo | 通用 | High-throughput human microfluidic organoid-on-a-chip platform | `Celvivo/10.1016_j.stemcr.2025.102646.md` |
 | `10.1016_j.stemcr.2025.102646_v2` | CelVivo | 通用 | 同上 v2 (重写) | `Celvivo/10.1016_j.stemcr.2025.102646_v2.md` |
-| DOI | Vendor | Application | Title (short) | Vault path |
+### 2026-06-24 (2 篇)
-| --- | --- | --- | --- | --- |
+| DOI | Vendor | 类器官 | 标题 | 路径 |
-| `10.1016_j.stemcr.2025.102646` (v1) | CelVivo | Generic | High-throughput human microfluidic organoid-on-a-chip platform | `Celvivo/10.1016_j.stemcr.2025.102646.md` |
+|---|---|---|---|---|
-| `10.1016_j.stemcr.2025.102646_v2` | CelVivo | Generic | Same as v1, rewritten | `Celvivo/10.1016_j.stemcr.2025.102646_v2.md` |
+| `10.1021_acsomega.5c02682` | 3Brain | 皮肤 | Developing tumor microenvironment in rotating human melanoma cell culture | `3Brain/10.1021_acsomega.5c02682.md` |
 | `10.1016_j.xpro.2025.103923` | CelVivo | 肺 | Protocol for the Establishment and Characterization of Lung Tumoroids | `Celvivo/10.1016_j.xpro.2025.103923.md` |
-### 2026-06-24 (2 papers)
+### 2026-06-23 (2 篇)
 | DOI | Vendor | 类器官 | 标题 | 路径 |
 |---|---|---|---|---|
 | `10.1002_jbm4.10792` | CelVivo | 通用 | High-throughput microfluidic organoid-on-a-chip (v2-munir2023) | `Celvivo/10.1002_jbm4.10792-v2-munir2023.md` |
 | `10.3390_cells11203216` | CelVivo | 肝 NAFLD | Mapping Proteome and Lipidome Changes in Early-Onset NAFLD | `Celvivo/10.3390_cells11203216.md` |
-| DOI | Vendor | Application | Title (short) | Vault path |
+## 按 Vendor 统计 (mtime 2026-06-16 → 2026-07-28)
 | --- | --- | --- | --- | --- |
 | `10.1021_acsomega.5c02682` | 3Brain | Skin | Developing tumor microenvironment in rotating human melanoma cell culture | `3Brain/10.1021_acsomega.5c02682.md` |
 | `10.1016_j.xpro.2025.103923` | CelVivo | Lung | Protocol for the Establishment and Characterization of Lung Tumoroids | `Celvivo/10.1016_j.xpro.2025.103923.md` |
-### 2026-06-23 (2 papers)
+| Vendor | 30 天精读数 | 最近一篇 |
 |---|---|---|
 | **CelVivo** | 5 篇 | 2026-07-05 |
 | **3Brain** | 1 篇 | 2026-06-24 |
 | **Cellink** | 1 篇 | 2026-07-27 |
 | **Ronawk Bio-Block** (KB 0 命中) | 1 篇 | 2026-07-28 |
-| DOI | Vendor | Application | Title (short) | Vault path |
+## 4 周 MSC 长期培养关键词命中 (累计)
 | --- | --- | --- | --- | --- |
 | `10.1002_jbm4.10792` | CelVivo | Generic | High-throughput microfluidic organoid-on-a-chip (v2-munir2023) | `Celvivo/10.1002_jbm4.10792-v2-munir2023.md` |
 | `10.3390_cells11203216` | CelVivo | Liver NAFLD | Mapping Proteome and Lipidome Changes in Early-Onset NAFLD | `Celvivo/10.3390_cells11203216.md` |
-## Vendor statistics (mtime 2026-06-16 → 2026-08-08)
+- `Bio-Block Ronawk 3D culture mesenchymal` (2026-07-28 入库, **未 KB 验证**; 4 周时窗 vs 2D/球体/Matrigel 平台对比)
 - `Hodge Mellott Bio-Block 3D culture` (2026-07-28 入库, **未 KB 验证**; 同上 Ronawk 团队 USC Kansas)
-| Vendor | 30-day deep-read count | Most recent | New this run (2026-08-08) |
+## ClinoReactor 关键词命中 (累计)
 | --- | ---: | --- | --- |
 | **CelVivo** | 5 | 2026-07-05 | — |
 | **3Brain** | 1 (+ Liu 2026 + Sharma 2026 as adjacent) | 2026-06-24 (canonical) / 2026-08-08 (Liu / Sharma as HD-MEA-adjacent) | Liu 2026 (HD-MEA rating 5), Sharma 2026 (HD-MEA rating 4) |
 | **Cellink** | 1 | 2026-07-27 | — |
 | **CelVivo + 3Brain cross** | 1 | 2026-07-27 | Miao 2025 v2 (CelVivo ClinoStar rating 5, HD-MEA rating 4) |
 | **Cellink + 3Brain cross** | 0 | — | Liu 2026 (3D bioprinting microlattice rating 5) |
 | **Across all 4 vendors** (Microbioreactor review) | 1 | 2026-08-08 | Rosero 2026 Front Bioeng Biotechnol (CAR-T / mAb / iPSC / organoid — 4 applications) |
 | **Brain organoid + THSDC** (NAMs adjacent) | 1 | 2026-08-08 | Fernandez Vallone 2026 Cells (hiPSC brain organoid THSDC platform, v2 5 张真图 + 双 H1; Wiki.js Id 1698) |
 | **Brain organoid + PD model** | 1 | 2026-08-06 | Parfitt 2024 Nat Commun (DJ1 LOF midbrain organoid PD model, untracked) |
 | **Ronawk Bio-Block** (KB 0 hit) | 1 | 2026-07-28 | — |
-## 4-week MSC long-term-culture keyword hits (cumulative)
+- `Planimetry measurements of spheroids in a ClinoReactor using FIJI` (2026-04-01 入库, **未精读**)
- `Bio-Block Ronawk 3D culture mesenchymal` (2026-07-28 added, **not KB-validated**; 4-week window vs 2D/spheroid/Matrigel platform comparison)
+## 跟 OpenWiki 其他源的关系
 - `Hodge Mellott Bio-Block 3D culture` (2026-07-28 added, **not KB-validated**; same Ronawk team USC Kansas)
-## ClinoReactor keyword hits (cumulative)
+| 源 | 看什么 |
 |---|---|
 | **本文件** (literature.md) | 精读笔记 (本文件) |
 | `sources/hackernews.md` | 外部公开讨论 |
 | `sources/git-repo.md` | vault 整体结构 |
 | `commitments.md` | Robin 任务承诺 |
 | `themes.md` | 跨源主题综合 |
- `Planimetry measurements of spheroids in a ClinoReactor using FIJI` (2026-04-01 added, **not yet deep-read**)
+## 触发查询示例 (MiniMax code 用)
-## Flywheel-sync pipeline (today, 2026-08-08)
+- "Robin 最近精读了哪些 CelVivo 文献" → 读本文件 CelVivo 段
 - "ClinoReactor 相关最新研究" → 读本文件 ClinoReactor 段 + ClinoReactor 关键词命中
 - "近一周有什么新文献" → 读本文件 "最近 7 天" 段
-The `~/.hermes/data_sources/literature_flywheel.jsonl` records each paper's 8-step pipeline status (`type_judgment` → `pdf_full_text` → `image_extract` → `ollama_audit` → `seafile_upload` → `report_written` → `wiki_published` → `nocodb_patched` → `obsidian_pushed` → `openwiki_pushed` → `flywheel_index`). Today's `flywheel_index` completions:
+## 维护方式
-| Paper | NocoDB destination | Wiki.js URL | Wiki Id |
+- **手动触发**: 通知 Robin "更新 literature 索引"
-| --- | --- | --- | ---: |
+- **自动**: OpenWiki cron 每天 02:00 跑 git-repo connector, 写本文件
-| Liu 2026 Nat Biomed Eng | **new table `Robin_Picked_Papers`** (created 2026-08-08, table_id `mbjo0wb56qv1qly`, row_id 1) | https://wiki.biokingdom.top/zh/literature/liu-2026-nbme-shape-conformal-organoid | 1692 |
+- **路径**: `~/.openwiki/wiki/sources/literature.md` (同步推 Gitea)
-| Miao 2025 Cell v2 | `Organoid_Literature` table (row 93) | https://wiki.biokingdom.top/zh/literature/miao-2025-cell-organoid-vascularization-v2 | 1681 |
+### 2026-07-28
-| Sharma 2026 Cell Stem Cell | `Organoid_Literature` table (row 700) | http://10.10.10.254:3000/zh/literature/sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc | 1678 |
+| DOI | Vendor | 类器官 | 标题 | 路径 |
 |---|---|---|---|---|
 | `10.1080_17460751.2025.2572177` | Ronawk Bio-Block (KB 0 命中) | MSC / 脂肪源 | Comparison of 3D culture systems on MSC longevity (Hodge 2025) | `RegenMed/10.1080_17460751.2025.2572177.md` |
 | `10.1186_s13287-018-1085-9` | KB: CelVivo+Cellink 命中 | MSC / 3D 漂浮 | Type I collagen deposition ameliorates YAP/TAZ (Komatsu 2018) | `Cellink/10.1186_s13287-018-1085-9.md` |
 | `10.3389_fvets.2025.1500267` | KB: 0 命中 | MSC 犬源 | Enhanced immunomodulation of canine MSC 3D (Lee 2025) | `Other/10.3389_fvets.2025.1500267.md` |
 | `10.1186_s13287-020-1566-5` | KB: CelVivo+Cellink 命中 | MSC / PEMF / 软骨 | PEMF potentiate MSC paracrine cartilage (Parate 2020) | `Other/10.1186_s13287-020-1566-5.md` |
-The `Robin_Picked_Papers` table is **new as of today** — created per Robin's 2026-08-08 instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage. Liu 2026 is the first entry. This is **separate** from the existing `Organoid_Literature` table (which Miao 2025 v2 + Sharma 2026 landed in).
+### 2026-08-04 (ITX 端 hermes test)
-
+| DOI | Vendor | 类器官 | 标题 | 路径 |
-## Cross-reference with other OpenWiki sources
+|---|---|---|---|---|
-
+| `10.1038_s41586-026-assembloids-periportal` | Nature 650, 438-449 | Liver / Assembloid | Human assembloids recapitulate periportal liver (Yuan 2026) | `Organoid/10.1038_s41586-026-assembloids-periportal.md` |
 | Source | Look here for |
 | --- | --- |
 | **This page** (`/sources/literature.md`) | Deep-read notes index + flywheel-sync pipeline status |
 | [`/sources/hackernews.md`](/sources/hackernews.md) | External public discussion |
 | [`/sources/git-repo.md`](/sources/git-repo.md) | Vault overall structure |
 | [`/commitments.md`](/commitments.md) | Robin's task commitments |
 | [`/themes.md`](/themes.md) | Cross-source synthesis |
 | [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) | CelVivo + 3Brain vendor synthesis (with HD-MEA + ClinoStar evidence anchors for Liu 2026 / Miao 2025 v2 / Sharma 2026) |
 | [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md) | Cellink + 3D bioprinting synthesis (with Liu 2026 microlattice evidence anchor) |
 ## Trigger queries (for MiniMax code)
 - "What CelVivo papers has Robin deep-read recently?" → read this page's CelVivo rows + `/themes/01-organoid-equipment.md` CelVivo section
 - "Latest ClinoReactor research" → read this page's ClinoReactor keyword hits + Miao 2025 v2 (vascularization cross-reference)
 - "What new papers in the past week?" → read this page's "Last 30 days" section, top 3 rows
 - "Liu 2026 shape-conformal neural organoid HD-MEA — what is it?" → [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md)
 - "Fernandez Vallone 2026 hiPSC brain organoid THSDC — what is it?" → deep-read at `obsidian-vault/04-Literature/Deep-Reads/Cells/fernandez-vallone-2026-thsdc-brain-organoids.md` (Wiki.js Id 1698, NocoDB row 3263, v2 with 5 张真图 + 双 H1)
 - "Parfitt 2024 DJ1 LOF midbrain organoid PD model — what is it?" → deep-read at `04-Literature/Deep-Reads/Brain/2026-08-06_Parfitt_GM_et_al_NatCommun_2024_DJ1_LOF_midbrain_organoid_PD.md` (Nat Commun 15:1071, PMID 38200091)
 ## 8-07 vault mtime additions (working-tree deep-reads — not yet on `main`)
 > Observed in the 2026-08-08 git-repo connector pull as **untracked files in the working tree**. These are working-tree deep-reads that the next LDR commits will fold onto `main`.
 | Path | Status | Note |
 | --- | --- | --- |
 | `Liu2026_NBME_shape_conformal_organoid.md` | untracked @ `/home/ldw/workspace/` | canonical 2026-08-08 paper; v2-v11 已经 commit `1614ccf9` to `main` |
 | `Miao2025_Cell_v2.md` | untracked @ `/home/ldw/workspace/` | canonical 2026-08-08 paper; v2 已 commit `1c05eee7` to `main` |
 | `Miao2025_Cell_vascularized_organoid.md` | untracked @ `/home/ldw/workspace/` | 出处未明 working copy |
 | `Microbioreactor_2026_Rosero_FrontBioeng.md` | untracked @ `/home/ldw/workspace/` | 2026-08-08 论文 working copy; v2 with SeaFile links 已 commit `65fef021` to `main` |
 | `04-Literature/Deep-Reads/Brain/2026-08-06_Parfitt_GM_et_al_NatCommun_2024_DJ1_LOF_midbrain_organoid_PD.md` | untracked (2026-08-06) | DJ1 LOF midbrain organoid PD model (Parfitt 2024 Nat Commun) |
 | `obsidian-vault/04-Literature/Deep-Reads/Cells/fernandez-vallone-2026-thsdc-brain-organoids.md` | untracked (2026-08-08) | Fernandez Vallone 2026 Cells hiPSC 脑类器官 THSDC (commits `6c16dc05` + `d7df3830`) |
 | `retinal_organoid_deep_read_2026-08-07.md` | untracked @ `/home/ldw/workspace/` | Sharma 2026 working copy |
 | `rustdesk-selfhosted-2026-08-05.md` | untracked @ `/home/ldw/workspace/obsidian-vault/` | 独立的 RustDesk 自建部署笔记 (related to `/sources/rustdesk-sop.md`) |
 | `dify精读进度-20260805.md` | untracked @ `/home/ldw/workspace/` | Dify 文档精读进度追踪 |
 | `literature_deepread_v6.py` + `__pycache__/` | untracked @ `/home/ldw/workspace/` | LDR pipeline v6 脚本 (脚本源) |
 | `文悦精读流程线.yml` v1-v5-clean | untracked @ `/home/ldw/workspace/` | Dify 精读流程线 workflow YAML (5 版迭代) |
 ## 8-07 _known_associations.md 接续
 > 2026-08-07 added Obsidian vault `02-Clients/Agents/_known_associations.md` 是 4 个经销商管理 Hook 升级 (commit `4b237a82`) 的输出。这页 index 是新引入的 cross-product mapping — connector 证据已在 [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) § "8-07 新增：_known_associations.md 索引" 索引。
 ## Maintenance
 - **Manual trigger:** notify Robin "update literature index"
 - **Automatic:** OpenWiki cron 02:00 daily runs the git-repo connector + observes the flywheel-sync jsonl; the `## Last 30 days of deep reads` section is updated by mtime census, and the `## Flywheel-sync pipeline` section is updated by inspecting the `flywheel_completed_at` field.
 - **Path:** `~/.openwiki/wiki/sources/literature.md` (synced to Gitea)
 ### 2026-08-11 - PMID 42041571
 - **Title**: Multiscale Comparative Analyses of OVB-Organoids and Cerebral Organoids
 - **Authors**: Yang J, Zhang X, Li S, Gao Z
 - **Journal**: Cells 2026, 15(8), 703 (MDPI, IF ~5.1, CC-BY OA)
 - **DOI**: 10.3390/cells15080703
 - **Wiki.js**: [ID 1708](http://10.10.10.254:3000/zh/organoid/ovb-cerebral-organoid-multiscale-2026)
 - **NocoDB Id**: 1103
 - **PDF**: [cells_15_00703.pdf](https://fb.biokingdom.top/f/582d1f055f6e4365a924/?raw=1) + 10 张真实配图(xref extract)
 - **Key finding**: Cells 2026 重磅 - OVB-organoids vs Cerebral 多尺度对比(中国军事医学科学院); Day 30 FOXG1+53.86% + VSX2+4.18%; TEM 突触+髓鞘; 1625 上调 + 2924 下调 DEGs; CHRNB2 6.5 倍差异; KEGG 富集到神经突触功能 vs 免疫炎症代谢
 - **Business relevance**: OVB-organoids + 3Brain MEA = 眼-脑协同发育研究完整解决方案
 - **Tags**: OVB-organoids, cerebral-organoids, brain-development, retinal-organoid, FOXG1, VSX2
 ### 2026-08-11 - PMID 41909700
 - **Title**: Organoid-microglia system for modeling the immune microenvironment of the brain and retina
 - **Authors**: Yu J, Tang B, Gu Z, Wang G, Liu A
 - **Journal**: Frontiers in Immunology 2026, 17:1747589
 - **DOI**: 10.3389/fimmu.2026.1747589
 - **Wiki.js**: [ID 1709](http://10.10.10.254:3000/zh/organoid/yu-2026-organoid-microglia-front-immunol)
 - **NocoDB Id**: 715
 - **PDF**: [yu_2026_organoid_microglia.pdf](https://fb.biokingdom.top/f/4537d08bf4d14c6db0bc/?dl=1) + 4 张真图
 - **Key finding**: 类器官-小胶质细胞共培养 3 大策略 + 6 大应用 (AD/ASD/视网膜/药筛/CRISPR/OoC); 神经-免疫体外模型空白填补
 - **Business relevance**: 3Brain MEA + CelVivo ClinoStar + Femtobiomed CellShot + Cellink BIO X 4 大产品线全交叉
 - **Tags**: 类器官, 小胶质细胞, 神经免疫, 脑-视网膜, 共培养
 ### 2026-08-11 - PMID 41686639
 - **Title**: High-throughput engineered tumor organoids reveal ROCK signaling as an immunotherapeutic target in triple-negative breast cancer
 - **Authors**: Zhou X, Zhu Y, Nicolas G, Wang Z, Lobie P, Ma S
 - **Journal**: Cell Reports 2026, 45:116987
 - **DOI**: 10.1016/j.celrep.2026.116987
 - **Wiki.js**: [ID 1710](http://10.10.10.254:3000/zh/organoid/zhou-2026-deo-rock-tnbc-cell-reports)
 - **NocoDB Id**: 3296
 - **PDF**: [zhou_2026_cell_reports_rock_tnbc.pdf](https://fb.biokingdom.top/f/bbe6f494811047c2bba0/?dl=1) + 6 张真图
 - **Key finding**: DEO 平台保留 TNBC 患者内源 TIL;ROCK 通路激动剂戊酸(PA)维持 TIL + 协同 anti-PD-1 解除 BLIS 亚型免疫抑制(联合治疗肿瘤抑制率 ~70%)
 - **Business relevance**: 4 大产品线全交叉 (CelVivo ClinoStar 培养/3Brain MEA 评估/Femtobiomed CellShot 基因编辑/Cellink BIO X 制造)
 - **Tags**: 肿瘤类器官, 三阴乳腺癌, ROCK信号, TIL, anti-PD-1, 戊酸, 马少华, BLIS亚型
 ### 2026-08-11 - PMID 41536916
 - **Title**: Artificial Intelligence Virtual Organoids (AIVOs)
 - **Authors**: Bai L, Su J
 - **Journal**: Bioactive Materials 2026 (IF 18.2)
 - **DOI**: 10.1016/j.bioactmat.2025.12.030
 - **Type**: Review
 - **Wiki.js**: [ID 1711](http://10.10.10.254:3000/zh/organoid/bai-2026-aivos-bioactmat)
 - **NocoDB Id**: 502
 - **PDF**: [bai_2026_bioactmat_aivos.pdf](https://fb.biokingdom.top/f/59c6a647037346a28197/?dl=1) + 6 张真图
 - **Key finding**: AI Virtual Organoids (AIVOs) = 物理类器官 + AI 数字孪生; 数据-模型-交互三层架构; 6 大临床应用方向
 - **Business relevance**: 4 大产品线 (CelVivo ClinoStar / 3Brain MEA / Femtobiomed CellShot / Cellink BIO X) 全部可对接 AIVOs 平台 = 完整 湿+干 实验方案
 - **Tags**: 综述, 类器官, 人工智能, 虚拟器官, 数字孪生, 多组学, Bioactive-Materials-2026
 | 10.1038/s41598-026-42990-2 | Sci Rep 2026 | Liver | Liang 2026 小鼠肝类器官成熟+纤维化建模平台 | obsidian-vault/04-Literature/Deep-Reads/Liver/2026-08-12_Liang_2026_SciRep_liver_organoid_fibrosis_platform.md |
@@ -3,26 +3,13 @@
 > 数据源: NocoDB 13 个文献库 + 2 个公司库 (实时,每次 OpenWiki cron 跑时更新)
 > 用途: MiniMax code / Hermes 跨 agent 问 "Robin 的 NocoDB 里有什么"
 > 更新: 自动（`~/.openwiki/update-sources.sh` 每天 02:30 拉一次,数据写入本页后 commit + push Gitea）
-> 上次同步: **2026-08-21T18:30:02Z** · **总记录数: 6620**
+> 上次同步: **2026-08-07T11:05:11Z** · **总记录数: 0**
 ## 13 个文献库 (实测计数)
 | Table ID | 库名 | 记录数 |
 | --- | --- | --- |
-| `mxobo9ugqsjiu0o` | brain_organoid_literature | 103 |
+ROWS_PLACEHOLDER
 | `mn5okgkuqpn061d` | intestinal_organoid_literature | 9 |
 | `moev05yaip3qthv` | Celvivo_literature (CORE) | 109 |
 | `mnv01eu4xoi7t81` | cardiac_organoid_literature | 11 |
 | `mwj6qjhuuksvs43` | cancer_organoid_literature | 129 |
 | `mx6vlorhme34zqt` | liver_organoid_literature | 28 |
 | `m4rz82bhhcrs2ip` | other_organoid_literature | 724 |
 | `m8abmmwrgchr9ni` | kidney_organoid_literature | 23 |
 | `mun191tsudjdtga` | retinal_organoid_literature | 4 |
 | `m65htyq25vmpysq` | Cellink_literature | 2499 |
 | `mri6u97xrxi0vvm` | organoid_literature (old) | 2786 |
 | `mr8wrky2um6gwev` | lung_organoid_literature | 48 |
 | `m76t4vsfar89w0h` | 3Brain_literature | 147 |
 ## 跟其他工具的互补关系
@@ -1,18 +0,0 @@
 ---
 type: Reference
 title: OpenWiki Upgrade Drift (auto-generated)
 last_checked: 2026-08-15T20:00:03Z
 ---
 # OpenWiki Upgrade Drift
 - Local installed: `v0.3.1`
 - npm latest: `v0.3.3`
 - Last checked: 2026-08-15T20:00:03Z
 ## Action (manual, no auto-upgrade)
 ```bash
 npm install -g openwiki@latest
 ```
 > **WARNING**: v0.3.1 → v0.4+ 可能有 breaking change. Read release notes first.
@@ -1,8 +1,7 @@
 ---
 type: "Reference"
 title: "RAGFlow 文档采样索引"
-description: "Document-level sample index of Robin's RAGFlow instance (http://10.10.10.254:9980) — 18 KBs / 32709 total docs / 401 sample entries (last sync 2026-08-03). Captures the 30-doc-per-request server-side limit + offset bug that forces 12 large KBs to single-page samples. Lets MiniMax code / Hermes see 'what's in each KB' without SQL queries; complements `/sources/ragflow.md` (KB-level health + counts)."
+openwiki_generated: true
 tags: [ragflow, evidence-index, source, kb-documents, sample, 2026-08-13]
 ---
 # RAGFlow 文档采样索引
@@ -3,7 +3,7 @@
 > 数据源: RAGFlow (http://10.10.10.254:9980/) 14 个 KB 全文检索结果
 > 用途: MiniMax code / Hermes 跨 agent 问 "Robin 的 RAGFlow 里有什么"
 > 更新: 自动同步可用性 + 手动维护 KB 列表
-> 上次同步: **2026-08-21T18:30:02Z** · landing 200 · /api/v1/datasets 401
+> 上次同步: **2026-08-07T11:05:11Z** · landing 200 · /api/v1/datasets 401
 ## RAGFlow 服务可用性
@@ -1,8 +1,7 @@
 ---
 type: "Reference"
 title: "RustDesk 自建 hbbs 完整配置笔记 (2026-08-05)"
-description: "End-to-end deployment note for Robin's self-hosted RustDesk relay server (hbbs + hbbr) — Unraid NAS container (10.10.10.254) + OpenWrt reverse-proxy (10.10.10.252) + Tencent Light Cloud (43.160.207.177) + ITX client (192.168.31.14), with permanent password + key config. Supports remote control of the ITX 24h host (per `/commitments.md` `itx-24h-host-build-2026-q3`) and Robin's travel-laptop remote-access workflow."
+openwiki_generated: true
 tags: [rustdesk, itx-24h-host, remote-access, sop, infra, 2026-08-13]
 ---
 # RustDesk 自建 hbbs 完整配置笔记 (2026-08-05)
@@ -1,8 +1,7 @@
 ---
 type: "Reference"
 title: "CelVivo 销售弹药清单 (2026-07-16 实战索引)"
-description: "Sales ammunition index for CelVivo ClinoStar / ClinoReactor — price-book SKUs (ClinoReactor 12-pack, ClinoStar, SP5D-24W, Demo kit), 8-protocol SOP series (ClinoReactor prep / media change / organoid gardening / speed-tuning / alginate / VitroGel), and 5 organ-specific application cases (HepG2, FTC-133, SCLC, TNBC, ClinoStar vs Orbital Shaker). Sources from RAGFlow CelVivo KB + CelVivo commercial KB; manually curated from Robin + Hermes 实战 lessons. Used by any agent answering CelVivo ClinoReactor pricing / demo / customer-pitch queries."
+openwiki_generated: true
 tags: [sales-ammunition, celvivo, clinoreactor, clinostar, evidence-index, 2026-08-13]
 ---
 # CelVivo 销售弹药清单 (2026-07-16 实战索引)
@@ -3,7 +3,7 @@
 > 数据源: SeaFile (http://10.10.10.254:9898/) 共 N 个资料库
 > 用途: MiniMax code / Hermes 跨 agent 上传 / 分享 / 删除文件
 > 更新: 自动（每天 02:30 同步,sources/seafile.md 刷新）
-> 上次同步: **2026-08-21T18:30:02Z** · 
+> 上次同步: **2026-08-07T11:05:11Z** · 
 ## 配置 (v1.2 skill, 2026-07-16)
@@ -1,8 +1,7 @@
 ---
 type: "Reference"
 title: "CelVivo + Vault 实时 mtime 快照 (2026-07-16 快照)"
-description: "Historical mtime snapshot of Robin's Obsidian vault from 2026-07-16 — captures CelVivo deep-read activity (0 new entries in the 7-day window 2026-07-09 → 2026-07-16; last activity 2026-07-05), 6 entries in the 30-day window, and ClinoReactor keyword hits. Provides a baseline reference for cross-agent vault state because WSL laptop vault is not directly readable from container agents. Pre-dates the 2026-08-07 distributor refresh + 2026-08-12 Liang 2026 / 2026-08-13 Review/ subfolder activity — superseded by `/themes/05-robin-research.md` for current vault state."
+openwiki_generated: true
 tags: [vault-snapshot, mtime, celvivo, historical-baseline, 2026-08-13]
 ---
 # CelVivo + Vault 实时 mtime 快照 (2026-07-16 快照)
@@ -1,89 +1,14 @@
 ---
 type: "Reference"
 title: "Web Search Evidence"
-description: "Compact, source-backed evidence and ingestion coverage for the web-search-1 Tavily lane tracking CelVivo, 3Brain, Cellink, and related organoid news."
+openwiki_generated: true
 tags: [source, web-search, tavily, celvivo, 3brain, cellink, organoids, 2026-08-12, 2026-08-15, 2026-08-16, 2026-08-17, 2026-08-18, 2026-08-19, 2026-08-20, 2026-08-21]
 timestamp: 2026-08-21T18:35:00Z
 ---
 # Web Search Evidence
-> Connector: `web-search-1` (Tavily). This page records compact, relevant evidence from Tavily pulls; search results are discovery leads, not vendor-confirmed announcements. Latest successful pull: 2026-08-03 18:08 UTC. The 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, 2026-08-17, 2026-08-18, 2026-08-19, 2026-08-20, and 2026-08-21 update attempts were skipped because the connector is disabled and `TAVILY_API_KEY` is not present; no new 24-hour evidence was available on any of these nine runs.
+> Connector: `web-search-1` (Tavily). This page records compact, relevant evidence from Tavily pulls; search results are discovery leads, not vendor-confirmed announcements. Latest pull: 2026-08-03 18:08 UTC.
-## 2026-08-21 attempted update — skipped
+## 2026-07-26 pull
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. The nightly searxng-fallback slot (`~/.openwiki/connectors/web-search/raw/2026-08-20T18-35-03-searxng-fallback/`) is also empty (confirmed empty on disk) — no web-search evidence of any kind landed in the 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, 2026-08-17, 2026-08-18, 2026-08-19, and 2026-08-20 runs hit the same blocker; this is the **ninth consecutive skip on the same code path**. To resolve: set `TAVILY_API_KEY` in the OpenWiki runtime environment and ensure the runtime registry refreshes the connector's enabled state.
 ## 2026-08-20 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. The nightly searxng-fallback slot (`~/.openwiki/connectors/web-search/raw/2026-08-19T18-35-03-searxng-fallback/`) is also empty — no web-search evidence of any kind landed in the 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, 2026-08-17, 2026-08-18, and 2026-08-19 runs hit the same blocker; the 2026-08-21 run hit the same blocker too. This was the **eighth consecutive skip on the same code path at the time of the 2026-08-20 attempt** (and the ninth skip including the 2026-08-21 follow-up). To resolve: set `TAVILY_API_KEY` in the OpenWiki runtime environment and ensure the runtime registry refreshes the connector's enabled state.
 ## 2026-08-19 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. The nightly searxng-fallback slot (`~/.openwiki/connectors/web-search/raw/2026-08-18T18-35-03-searxng-fallback/`) is also empty — no web-search evidence of any kind landed in the 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, 2026-08-17, and 2026-08-18 runs hit the same blocker; the 2026-08-20 and 2026-08-21 runs hit the same blocker too. This was the **seventh consecutive skip on the same code path at the time of the 2026-08-19 attempt** (and the ninth skip including the 2026-08-20 and 2026-08-21 follow-ups). To resolve: set `TAVILY_API_KEY` in the OpenWiki runtime environment and ensure the runtime registry refreshes the connector's enabled state.
 ## 2026-08-18 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. The nightly searxng-fallback slot (`~/.openwiki/connectors/web-search/raw/2026-08-17T18-35-03-searxng-fallback/`) is also empty — no web-search evidence of any kind landed in the 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, and 2026-08-17 runs hit the same blocker; the 2026-08-19, 2026-08-20, and 2026-08-21 runs hit the same blocker too. This was the **sixth consecutive skip on the same code path at the time of the 2026-08-18 attempt** (and the ninth skip including the 2026-08-19, 2026-08-20, and 2026-08-21 follow-ups).
 ## 2026-08-17 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. The nightly searxng-fallback slot (`~/.openwiki/connectors/web-search/raw/2026-08-16T18-35-03-searxng-fallback/`) is also empty — no web-search evidence of any kind landed in the 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, 2026-08-12, and 2026-08-15 runs hit the same blocker; the 2026-08-18, 2026-08-19, 2026-08-20, and 2026-08-21 runs hit the same blocker too. This was the **fifth consecutive skip on the same code path at the time of the 2026-08-17 attempt** (and the ninth skip including the 2026-08-18, 2026-08-19, 2026-08-20, and 2026-08-21 follow-ups).
 ## 2026-08-15 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, and 2026-08-12 runs hit the same blocker; the 2026-08-17, 2026-08-18, 2026-08-19, 2026-08-20, and 2026-08-21 runs hit the same blocker too. This was the fourth consecutive skip on the same code path at the time of the 2026-08-15 attempt (and the ninth skip including the 2026-08-17, 2026-08-18, 2026-08-19, 2026-08-20, and 2026-08-21 follow-ups).
 ## 2026-08-12 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08 and 2026-08-10 runs hit the same blocker; this is the third consecutive skip on the same code path.
 ## 2026-08-10 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits.
 ## 2026-08-08 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 ## Historical successful pulls
 The detailed pull records below preserve the prior evidence trail in chronological order.
 ### 3D spheroid automation and assay standardization — source-backed
@@ -190,7 +115,7 @@ Third Tavily pull on the same day, after the 2026-07-27 `~/.openwiki/INSTRUCTION
 ### Coverage note for next update
 The China CDE regulatory lane is no longer being refreshed on every Tavily pull. The existing `/commitments.md` item pins it as `source-backed` with one credible cisema.com source. If a future Tavily or HN pull surfaces an NMPA / CDE-direct corroboration, promote from watchlist to `source-backed` and move into `/themes.md` as a confirmed row.
-## 2026-07-27 18:04 pull
+ll
 Fourth Tavily pull on the 2026-07-27 cycle, run as a stand-alone `openwiki personal --update` source ingest. All 10 queries were re-run. Two lanes produced genuinely new material evidence (CelVivo / ClinoReactor vendor-anchored signal; Hermes Agent v0.19 Quicksilver workflow-tooling release). One lane (3D-bioprinted-organoid reviews) added supporting evidence to the existing `class-organoid-3d-bioprinting` row. The Tavily answer-text mis-attribution pattern recurred on the 3Brain, Cellink, and MiniMax-M3 lanes — flagged again below.
@@ -534,8 +459,6 @@ Every query in the 10-query lane returned the same structured error (no answer t
 - Pull 9: fetched 2026-08-01T18:09:15Z — raw `~/.openwiki/connectors/web-search/raw/2026-08-01T18-07-35-101Z/web-search-results.json` — **all 10 queries returned `"error": "fetch failed"`; no usable evidence (gap-fill, not documented at the time)**
 - Pull 10: fetched 2026-08-02T18:07:53Z — raw `~/.openwiki/connectors/web-search/raw/2026-08-02T18-06-12-521Z/web-search-results.json` — **all 10 queries returned `"error": "fetch failed"`; no usable evidence**
 - Pull 11: fetched 2026-08-03T18:08:50Z — raw `~/.openwiki/connectors/web-search/raw/2026-08-03T18-07-31-803Z/web-search-results.json` — **first successful pull after the 3-day outage streak; Tavily back online; see section below**
 - Pull 12: attempted 2026-08-10T18:35Z — **skipped** (connector reported disabled; `TAVILY_API_KEY` not present; no raw files written; no synthesis update)
 - 2026-08-12 / 2026-08-15 / 2026-08-17 / 2026-08-18 / 2026-08-19 / 2026-08-20 / 2026-08-21 update attempts: all **skipped** on the same code path (connector reported disabled; `TAVILY_API_KEY` not present; no raw files written; no synthesis update; ninth consecutive skip including 2026-08-21); see individual sections above for per-day operational notes
 - Queries: pulls 1, 2, 4, 5, 6, 7, 8, 9, 10, 11 = 10 queries each; pull 3 = 6 queries (vendor-anchored only)
 - Instance: `web-search-1`
@@ -608,25 +531,3 @@ Eleventh Tavily pull, run as a stand-alone `openwiki personal --update` source i
 - **Tavily answer-text quality:** the 3Brain answer is now correct (first time in 11 pulls); the Cellink Lumen X answer is substantive; the Hermes/M3 answer is partially fabricated ("release date of June 1, 2026") — treat as untrusted. Connector-side quality flag for future pulls: continue to treat Tavily answer text as untrusted; trust the underlying URL + score + published_date.
 - **Operational note for the connector:** Tavily is back online after a 3-day outage streak. The pull 8 / pull 9 / pull 10 advice to check `TAVILY_API_KEY`, Tavily status, and rate-limit posture no longer applies — the lane is functional again. No connector-side configuration change is required.
 - **Coverage:** fetched `2026-08-03T18:08:50.866Z`; 10 queries; raw `~/.openwiki/connectors/web-search/raw/2026-08-03T18-07-31-803Z/web-search-results.json`; instance `web-search-1`.
 on the existing `3brain-coreplate-2026-conference-positioning` verification commitment. No new commitment; existing commitment Notes are extended.
  3. **CelVivo ClinoStar 2 / Thailand Lab 2026** — independent confirmation from an Indian distributor event page on the existing `celvivo-clinostar-2-nams-demo-2026` verification commitment. No new commitment; existing commitment Notes are extended.
 - **Workflow tooling refreshes:** `agent-memory-architecture` Last seen → 2026-08-03 (akitaonrails/ai-memory research doc added). `hermes-agent-v0-19-quicksilver` and `MiniMax-m3` evidence columns refreshed with same-week artifacts (Last seen unchanged at 2026-08-03 from the HN pull).
 - **Tavily answer-text quality:** the 3Brain answer is now correct (first time in 11 pulls); the Cellink Lumen X answer is substantive; the Hermes/M3 answer is partially fabricated ("release date of June 1, 2026") — treat as untrusted. Connector-side quality flag for future pulls: continue to treat Tavily answer text as untrusted; trust the underlying URL + score + published_date.
 - **Operational note for the connector:** Tavily is back online after a 3-day outage streak. The pull 8 / pull 9 / pull 10 advice to check `TAVILY_API_KEY`, Tavily status, and rate-limit posture no longer applies — the lane is functional again. No connector-side configuration change is required.
 - **Coverage:** fetched `2026-08-03T18:08:50.866Z`; 10 queries; raw `~/.openwiki/connectors/web-search/raw/2026-08-03T18-07-31-803Z/web-search-results.json`; instance `web-search-1`.
 queries; raw `~/.openwiki/connectors/web-search/raw/2026-08-03T18-07-31-803Z/web-search-results.json`; instance `web-search-1`.
 ion commitment. No new commitment; existing commitment Notes are extended.
  3. **CelVivo ClinoStar 2 / Thailand Lab 2026** — independent confirmation from an Indian distributor event page on the existing `celvivo-clinostar-2-nams-demo-2026` verification commitment. No new commitment; existing commitment Notes are extended.
 - **Workflow tooling refreshes:** `agent-memory-architecture` Last seen → 2026-08-03 (akitaonrails/ai-memory research doc added). `hermes-agent-v0-19-quicksilver` and `MiniMax-m3` evidence columns refreshed with same-week artifacts (Last seen unchanged at 2026-08-03 from the HN pull).
 - **Tavily answer-text quality:** the 3Brain answer is now correct (first time in 11 pulls); the Cellink Lumen X answer is substantive; the Hermes/M3 answer is partially fabricated ("release date of June 1, 2026") — treat as untrusted. Connector-side quality flag for future pulls: continue to treat Tavily answer text as untrusted; trust the underlying URL + score + published_date.
 - **Operational note for the connector:** Tavily is back online after a 3-day outage streak. The pull 8 / pull 9 / pull 10 advice to check `TAVILY_API_KEY`, Tavily status, and rate-limit posture no longer applies — the lane is functional again. No connector-side configuration change is required.
 - **Coverage:** fetched `2026-08-03T18:08:50.866Z`; 10 queries; raw `~/.openwiki/connectors/web-search/raw/2026-08-03T18-07-31-803Z/web-search-results.json`; instance `web-search-1`.
 queries; raw `~/.openwiki/connectors/web-search/raw/2026-08-03T18-07-31-803Z/web-search-results.json`; instance `web-search-1`.
 .
 h-1`.
 penwiki/connectors/web-search/raw/2026-08-03T18-07-31-803Z/web-search-results.json`; instance `web-search-1`.
 h-1`.
 nwiki/connectors/web-search/raw/2026-08-03T18-07-31-803Z/web-search-results.json`; instance `web-search-1`.
 h-1`.
@@ -3,7 +3,7 @@
 > 数据源: Wiki.js (http://10.10.10.254:3000/graphql) Biokingdom 实例
 > 用途: MiniMax code / Hermes 跨 agent 检索 "Robin 在 Wiki.js 发布了什么"
 > 更新: 自动同步计数 + 手动维护目录
-> 上次同步: **2026-08-21T18:30:02Z** · GraphQL sample (5 orderBy union): **83 unique pages** · ID range 22..1704 · 分布 en=5, zh=78
+> 上次同步: **2026-08-07T11:05:11Z** · GraphQL sample (5 orderBy union): **82 unique pages** · ID range 22..1648 · 分布 en=5, zh=77
 ## Wiki.js 概况
@@ -12,10 +12,10 @@
 | GraphQL API | `http://10.10.10.254:3000/graphql` |
 | Web UI (zh) | `http://10.10.10.254:3000/zh/home` |
 | Web UI (en) | `http://10.10.10.254:3000/en/home` |
-| **估计全页数** | **≥ 1704 (基于 max page id)** — server-side ID gap 显著,实际数大于 sample union |
+| **估计全页数** | **≥ 1648 (基于 max page id)** — server-side ID gap 显著,实际数大于 sample union |
-| Sample union (5 orderBy) | 83 unique pages (GraphQL 返 50 cap) |
+| Sample union (5 orderBy) | 82 unique pages (GraphQL 返 50 cap) |
-| Min / Max ID | 22 / 1704 |
+| Min / Max ID | 22 / 1648 |
-| Locale 分布 (sample) | en=5, zh=78 |
+| Locale 分布 (sample) | en=5, zh=77 |
 | Top-level 路径分布 (前 8, sample) | organoid=50, products=7, literature=5, articles=4, 3brain=2, 3brain-biocam-driver-api-v2-5=1, 3brain-hdmea-system=1, instruments=1 |
 | 主题 | 类器官 / 3D 生物打印 / HD-MEA / CRISPR 类器官精准医疗 |
 | 维护者 | Robin + LDR (literature-reading-queue skill 自动发布) |
@@ -59,10 +59,6 @@ The state diagram shows the canonical CelVivo → 3Brain workflow: 3D suspension
 - **Whitepaper: "Breaking the Bias" (2026, 16 pp)** — CelVivo's official vendor narrative on brain organoid long-term culture. Key data: ~110 day / 8 mm diameter brain organoid (Univ. Groningen, Trombetta-Lima); sc-RNA-seq 17,738 cells at Day 90 (Univ. Lausanne, Bagni); Day 30/45 dorsal forebrain comparison vs orbital shaker (Drexel, Qiang); hiPSC → cortical organoid + Omicron BA.5 (QIMR Berghofer, Stewart 2022). 4 patents: WO 2021/001472, WO 2021/245117, WO 2022/008292, WO 2022/144461. Full synthesis at [`/sources/literature-celvivo-brain-whitepaper-2026.md`](/sources/literature-celvivo-brain-whitepaper-2026.md).
 - **Bosnjakovic 2025 bioRxiv (PAH HepG2 3D spheroid, ClinoStar dynamic culture)** — 21-day maturation + 24h/96h BaP/BBF exposure; **4 metabolic markers (phenylalanine, TCA intermediates, GSH depletion, sphingolipid dysregulation) only appear in 3D, completely invisible in 2D**. Sales ammunition: "your 2D model is missing 100% of environmental toxicology early signals". Synthesis at [`/sources/literature-cel-bosnjakovic-2025-pah-deepread.md`](/sources/literature-cel-bosnjakovic-2025-pah-deepread.md).
 - **Miao 2025 Cell v2 (co-differentiation mesoderm + endoderm, vascularized lung/gut organoids, ClinoStar rotating culture)** — single 3D EB co-induction strategy yields **vHLPO with 7% ECs vs traditional HLPO 0%**, organ-specific endothelium + mesenchyme scRNA-seq validation, in-vivo functional integration with host circulation, FOXF1 mutation ACDMPV dual-pathology disease modeling. Product relevance: CelVivo ClinoStar rating 5 (co-differentiation depends on 3D EB self-organization in low-shear rotating culture — ClinoStar is the canonical hardware), HD-MEA rating 4, 3D bioprinting rating 3, patient-derived organoid drug screening rating 5. Synthesis at [`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`](/sources/literature-miao-2025-cell-vascularization-v2-deepread.md).
 - **Liu 2026 Nat Biomed Eng (shape-conformal porous framework for neural organoid e-phys, Rogers Lab)** — CelVivo ClinoStar rating 4 (organoid culture downstream of the shape-conformal framework; long-term maturation + functional readout is the canonical ClinoStar → HD-MEA workflow). Synthesis at [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md). See 3Brain evidence for the HD-MEA read side.
 - **Quintard 2024 Nat Commun (microfluidic platform integrating functional vascularized organoids-on-chip, 2026-08-16)** — CelVivo ClinoStar rating 3 (upstream workflow: BVO differentiation day 0-15 needs rotating-wall suspension culture; ClinoStar is the canonical hardware for this stage; the paper's day 15 → chip-on-board handoff is the canonical CelVivo → organ-on-chip workflow). Mimetas OrganoPlate rating 4 (direct Phaseguide-based vascularized / kidney / intestine organ-on-chip competitor — Robin's portfolio does not currently cover Mimetas but the platform represents a candidate cross-sell if Robin's customers ask "where do I run my CelVivo-matured organoids in a vascularized microenvironment?"). Emulate Organ-Chip rating 3 (Colon-Intestine-Liver platform companion). 10 通道并行微流控芯片 + hiPSC-BVO + 间充质球体 + 胰岛球体 + 肺类器官 跨类器官验证; 血管层级化 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管; 壁剪切 27-2000 s⁻¹ 完美匹配人体毛细血管生理范围 50-1900 s⁻¹. 4-commit LDR cycle 2026-08-16 (commits `0fc8db24` → `290e9635` → `24c713de` → `4073abf4` — last commit deleted the 3Brain reference per the SOP "硬门槛合规修正" cleanup rule because Quintard is organ-on-chip territory rather than 3Brain territory). Wiki IDs 1719/1720/1722, NocoDB Id 3297, DOI 10.1038/s41467-024-45710-4. Sales ammunition: "你的类器官前段培养到 day 15, 后段血管化怎么接? 我们的 CelVivo ClinoStar 提供 day 0-15 金标准旋转培养, 后接 Quintard 2024 微流控芯片做 30 天功能性血管化灌注". Customer entry: 药企临床前 (vascularized drug screening) + 微流控 organ-on-chip 平台集成商 (Mimetas / Emulate channel partners) + academic PI (vascular development / diabetes). Vault path: `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` (189 lines + 6 真图).
 - **Liang 2026 Sci Rep (mouse liver organoid 3-轨道 + fibrosis modeling, 2026-08-12)** — CelVivo ClinoStar rating 4 (P1-P10 长程扩增对应旋转培养 30+ 天无剪切; single DAPT only sustains P5, DAPT+Dex 协同才实现 P10 稳定成熟), CelVivo ClinoReactor rating 4 (单组织 3 轨道 [Hep/Cho/HSC] 分通道灌流; TGFβ 时间程序精确切换实现纤维化激活模型), CelVivo PhaseHolographic 成像 rating 3 (3D 球体直径/CV 实时 QC), 3Brain HD-MEA rating 3 (肝-神经互作延伸场景). 3 轨道 from 单份小鼠肝组织 (密度梯度离心 + 差速贴壁) → DAPT+Dex P1-P10 长程稳定成熟 (ALB / PAS / LDL / CYP 跨代保持) → TGFβ 5-7 天激活 qHSC → aHSC (Acta2/Col1a1 上调) → aHSC 共培养诱导 Hep-Orgs EMT (Snail/Twist/Vimentin ↑; ALB/CK8 ↓; Lgr5/EpCAM ↓; Ki67 ↓) = 体外肝纤维化模型. Wiki.js Id=1716, NocoDB Id=770, PMID 41857098. Page 946 9 项 SOP 重写版 + page 934 修齐 标杆 (4-commit LDR cycle 2026-08-12). **First deep-read whose `related:` field already names `[[MOC-类器官与3D培养]]`** on the day of publication — confirms MOC pattern in active use on real deep-reads. Vault path: `04-Literature/Deep-Reads/Liver/2026-08-12_Liang_2026_SciRep_liver_organoid_fibrosis_platform.md` (170 lines). Sales ammunition: "你的肝类器官只能短期培养? DAPT+Dex P1-P10 稳定成熟 + 单组织 3 轨道 + 14 天纤维化模型 — ClinoStar + ClinoReactor 一站搞定". Customer entry: 药企临床前 (抗纤维化药筛 14+ 天 3D 多细胞模型) + 临床肝活检中心 (1-2 mg 组织 → 3 周药敏 → ClinoReactor 6 通道一次测 6 药). Tracks in `/commitments.md` as `liang-2026-celvivo-clinostar-positioning`.
 - **Sales ammunition kit (CelVivo pricing + 8 Protocols + 5 app notes + 5 brand/whitepapers)** — Demo kit `10005-6` lists at €300 (Global Distributor Price, with special discount). 8 ClinoReactor Protocols cover prepare / media change / gardening / plate config / rotation-speed / alginate embed / VitroGel embed. 5 application notes cover HepG2/C3A liver, FTC-133 thyroid, NCI-H69V SCLC, TNBC, ClinoStar vs Orbital Shaker. Synthesis at [`/sources/sales-ammunition.md`](/sources/sales-ammunition.md).
 - **260528_CS vs OS app note (2026-07-17 deep read)** — ClinoStar vs Orbital Shaker shear-stress comparison for long-term 3D construct performance; ClinoStar has lower shear + long-term growth + better consistency. This is the **vs-competitor killer document** for "why not use an orbital shaker" customer questions.
 - **111_Planimetry app note (2026-07-17 deep read)** — Planimetry measurements of spheroids in ClinoReactor using FIJI (open-source). Standard answer for "how to quantify spheroids".
@@ -70,8 +66,6 @@ The state diagram shows the canonical CelVivo → 3Brain workflow: 3D suspension
 ### 3Brain evidence
 - **Raji 2026 Mol Psychiatry (hMOs + 3Brain HD-MEA, 2026-07-27 deep read)** — WNT-modulated human midbrain organoids + 3Brain BioCAM DupleX + Accura-3D (4096 electrodes) + BrainWave 5. **TH+ 58% at 12 weeks** (vs 2D 18%, 3D static 32%). DA release 76 pg/mL (vs 2D 12, 3D static 28). α-synuclein PFF → DA neurons -35% / TH -40% / DA release -45% — establishes the **PD drug screening platform**. Shear-stress 15x lower than orbital shaking (0.13 dyn/cm² vs 2.03 dyn/cm²). Synthesis at [`/sources/literature-raji-2026-deepread.md`](/sources/literature-raji-2026-deepread.md).
 - **Liu 2026 Nat Biomed Eng (shape-conformal porous framework, full-coverage neural organoid e-phys, Rogers Lab)** — HD-MEA rating 5: **3000-8000 channels per organoid vs traditional MEA 200-1000 (10-50× improvement), >90% surface coverage vs 5-15%, weeks-long stable recording + bi-directional electrical + optogenetic stimulation, epilepsy + AD disease modeling**. The framework is the **direct next-generation design reference** for 3Brain's current 4096-electrode Accura-3D; Robin should sell Accura-3D as the existing best-in-class and Liu 2026 as the forward-looking 3D-coverage direction. Synthesis at [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md). Tracks as `liu-2026-hd-mea-roadmap-implication` commitment (verify with 3Brain whether flexible-electronics / shape-conformal framework is on their roadmap).
 - **Sharma 2026 Cell Stem Cell (vascularized retinal organoids, RGC survival)** — HD-MEA rating 4: paper uses 60-channel MCS MEA2100-Lite; 3Brain HD-MEA is same-generation HD technology, technical route is transferable. The W31 ON/OFF/ON-OFF light-response recording paradigm is the kind of long-duration, multi-class recording where HD spatial resolution matters most. CelVivo ClinoStar rating 3 (vascular network regresses in static culture → ClinoStar low-shear route candidate). W18 RGC yield **18.2% vs ctrl-RO 1.21% (15× improvement)** through C3 endothelial monolayer integration. Synthesis at [`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`](/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md).
 - **3Brain Sample Holder Set / PressNet (UK GB2624872)** — Mechanical net-press device for CorePlate 1W/6W; load force 250–1250 µN. Recorded 2026-07-07 (untracked in vault). Carryover evidence in [`/sources/git-repo.md`](/sources/git-repo.md) Notable entities.
 - **3Brain end-customer dossiers** — 11+ dossiers under `03-Resources/End-Customers/` covering 神经所 (上海), 北京大学, 北京天坛医院, 浙大一附院, 中科院昆明动物所, 西南医科大学, 贵州医科大学, plus TCM accounts at 云南中医药大学 and 天津创新中药. Listed in [`/sources/git-repo.md`](/sources/git-repo.md) Notable entities.
 - **Vendor-channel strand (Tavily 2026-07-30 → 2026-08-03)** — 3Brain's official website + LinkedIn (booth 412 at ISSCR 2026; booth 4 at ELRIG Drug Discovery; Utrecht Summer School "Human Brain Models" course 2026-07-29). Tracks in `/commitments.md` as `3brain-coreplate-2026-conference-positioning` (verify which conference posts are current and pull application notes).
@@ -79,8 +73,6 @@ The state diagram shows the canonical CelVivo → 3Brain workflow: 3D suspension
 ## Cross-vendor workflow links
 - **CelVivo + 3Brain joint workflow** (from Raji 2026): hMOs are cultured in a **bioreactor** (CelVivo-class, low-shear rotating-wall) for 12 weeks; transplanted to **3Brain Accura-3D** (4096-electrode HD-MEA chip) for 24h spike-train recording via BrainWave 5. Two pieces of hardware from two vendors compose the **PD drug screening platform** Robin sells.
 - **CelVivo + 3Brain next-gen workflow** (from Liu 2026): the shape-conformal porous framework (Rogers Lab, next-gen HD-MEA design) records 3000-8000 channels per organoid vs current 4096 — **forward-looking direction** for the CelVivo → 3Brain pipeline. Track in `/commitments.md` as `liu-2026-hd-mea-roadmap-implication`.
 - **CelVivo + 3Brain vascularized organoid workflow** (from Miao 2025 v2 + Sharma 2026): vHLPO and vRO use single 3D EB co-induction (mesoderm+endoderm) or C3 endothelial monolayer integration. The vascular-like networks regress in static culture — **CelVivo ClinoStar low-shear rotating culture is the candidate route to extend maturation**. Functional readout remains 3Brain HD-MEA territory (60-channel MEA in Sharma; future HD-MEA for vascularized organoids).
 - **CelVivo + TheWell Bioscience xeno-free workflow** (Tavily 2026-07-21/23/25): TheWell's hydrogel-media workflow pages position **ClinoReactor as the scale-up vessel for apical-out organoids + hMSC expansion**. Tracks in `/commitments.md` as `celvivo-clinoreactor-thewell-bioscience-xeno-free` (verify whether sanctioned co-marketing).
 - **CelVivo + Femtobiomed** (small but complementary): Femtobiomed CellShot / CellPick / TriArm for hiPSC electroporation upstream of CelVivo 3D culture.
@@ -94,7 +86,6 @@ The state diagram shows the canonical CelVivo → 3Brain workflow: 3D suspension
 - **China CDE cell & gene therapy classification rules (2026-07-24)** — affects CelVivo-class deals in the Chinese pharma R&D / CDMO customer base. Tracks in [`/commitments.md`](/commitments.md) `china-cde-cell-gene-therapy-rules-2026`.
 - **China Order No. 818 (effective 2026-05-01)** — accelerated clinical-translation pathway for cell therapy and 3D bioprinting at qualified hospitals. Tracks as `china-order-no-818-clinical-translation`.
 - **Guo 2026 Front Cell Dev Biol organoid IRB / ethics systematic review (2026-08-16)** — CelVivo ClinoStar ⭐⭐⭐⭐ clinical-translation IRB compliance; **Robin 推广 ClinoStar 给三甲医院时, 可附带 Guo 2026 框架作为增值**. The paper structures the IRB review framework as 7 mandatory points (sample provenance + donor informed consent + data privacy & de-identification + co-culture agency + animal welfare 3R + cross-border regulation + long-term storage & termination) + a 5-jurisdiction cross-border table (China《人类遗传资源管理条例》+《涉及人的生命科学和医学研究伦理审查办法》2023 vs US HIPAA + Common Rule + NIH GDS vs EU GDPR + Clinical Trials Regulation 536/2014 vs Japan / Korea). 3-commit LDR cycle 2026-08-16 (`2e6f5989` → `00f824f2` → `a4fa5a32`). Wiki.js ID 1724, NocoDB Id 3298, DOI 10.3389/fcell.2026.1721946. **Robin translated the paper into a customer-facing IRB application checklist template** at `templates/类器官IRB申请清单.md` v1.0 (180 lines; 7 mandatory points checklist + 5 customer Q&A + China vs International flow table + 10 attachments + 7 citations). Tracks in `/commitments.md` as `guo-2026-organoid-irb-checklist-rollout` (Owner: me; fold IRB application checklist into CelVivo industrial-customers program + Robin customer-training core material; commit the template and add a synthesis page at `/sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md`). Vault path: `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` (170 lines + 3 真图).
 - **China CGT 2026-07 developments** — Merck–Bio-Techne $11.3B acquisition, CARsgen satri-cel solid-tumor CAR-T approval (positive); gene-editing trial death + regulatory backlash (negative). Tracks as `china-cgt-2026-july-developments`.
 ## Cross-cutting relationship
@@ -110,15 +101,8 @@ The state diagram shows the canonical CelVivo → 3Brain workflow: 3D suspension
 | What is ClinoReactor's pricing? | [`/sources/sales-ammunition.md`](/sources/sales-ammunition.md) |
 | What does the CelVivo brain organoid whitepaper actually say? | [`/sources/literature-celvivo-brain-whitepaper-2026.md`](/sources/literature-celvivo-brain-whitepaper-2026.md) |
 | What is Raji 2026's PD drug screening story? | [`/sources/literature-raji-2026-deepread.md`](/sources/literature-raji-2026-deepread.md) |
 | What is Miao 2025's vascularized lung/gut organoid story? | [`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`](/sources/literature-miao-2025-cell-vascularization-v2-deepread.md) |
 | What is Liu 2026's shape-conformal neural organoid e-phys story? | [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md) |
 | What is Sharma 2026's vascularized retinal organoid RGC story? | [`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`](/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md) |
 | What is Liang 2026's liver organoid fibrosis platform story? | `04-Literature/Deep-Reads/Liver/2026-08-12_Liang_2026_SciRep_liver_organoid_fibrosis_platform.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
 | What is Quintard 2024's vascularized organoid chip story? | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
 | What is Guo 2026's organoid IRB / ethics story? | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
 | What is the IRB application checklist for organoid research? | `templates/类器官IRB申请清单.md` v1.0 (vault path; untracked) |
 | What distributors am I actually working with? | [`/sources/agents.md`](/sources/agents.md) |
 | Which Chinese dealers carry our brand? | [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) |
-| What regulatory shifts affect our Chinese pharma deals? | [`/commitments.md`](/commitments.md) China CDE / Order No. 818 / Guo 2026 IRB / China CGT items |
+| What regulatory shifts affect our Chinese pharma deals? | [`/commitments.md`](/commitments.md) China CDE / Order No. 818 / China CGT items |
 | What conferences is 3Brain at this season? | [`/commitments.md`](/commitments.md) `3brain-coreplate-2026-conference-positioning` |
 | What's the CelVivo → 3Brain joint workflow? | [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) (this page) Workflow chain section |
@@ -48,7 +48,6 @@ This is the synthesis page for **3D 生物打印** — Robin's 3D bioprinting pr
 The 3D bioprinting lane also captures application-domain papers that bioprint scaffolds for organoid culture — these are **vendor-adjacent** signals that fold into the [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) organoid culture theme rather than into Cellink hardware sales:
 - **Liu 2026 Nat Biomed Eng (shape-conformal porous framework, Rogers Lab, 2026-08-08 deep read)** — flexible-electronics microlattice fabrication as a 3D-bioprinting-adjacent technology for neural organoid scaffolds. **3D bioprinting rating 5** — the microlattice fabrication technique depends on 3D printing-class resolution (Cellink BIO X / BIONOVA X / Lumen X cannot directly print at this resolution today, but the field direction is clear: future bioprinters will integrate flexible-electronics fabrication). The framework records 3000-8000 channels per organoid (>90% surface coverage, weeks-long stable recording, epilepsy + AD disease modeling) — Robin should pitch Liu 2026 to Cellink to understand whether BIONOVA X or Lumen X can fabricate flexible-electronics-compatible microlattices. Synthesis at [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md). First entry in the new NocoDB table `Robin_Picked_Papers` (created 2026-08-08).
 - **MDPI Cells 2026-07-27** — "Rapid Volumetric Bioprinting Coupled with Dynamic Perfusion Enhances Human Hepatic Organoid Toxicity Testing"
 - **GEN 2026-07-29** — "Large Bioprinted Tissues Get a Precision Boost"
 - **HepatoBiliary Surgery and Nutrition 2026-08-01** — "Spatial architecture and dynamic surveillance: 3D bioprinting and microfluidics converge" (strongest same-week cross-anchor between organ-on-chip and 3D-bioprinting)
@@ -95,5 +94,4 @@ The bioprinting theme is **evidence-light compared to theme 1 (organoid-equipmen
 | Is the New Lumen X product release verified? | [`/commitments.md`](/commitments.md) `cellink-volumetric-lumen-x-release` |
 | Are there BIO X Gen 3 / BIO X6 customer installs in China? | [`/commitments.md`](/commitments.md) `cellink-bio-x-gen3-customer-evidence` |
 | What distributors carry Cellink in China? | [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) |
-| What 3D bioprinted-organoid reviews have come out this month? | [`/sources/web-search.md`](/sources/web-search.md) 2026-07-29 / 2026-07-30 / 2026-08-03 pulls |
+| What 3D bioprinted-organoid reviews have come out this month? | [`/sources/web-search.md`](/sources/web-search.md) 2026-07-29 / 2026-07-30 / 2026-08-03 pulls |
 | What is Liu 2026's shape-conformal neural organoid framework story (microlattice + flexible electronics)? | [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md) |
@@ -19,29 +19,30 @@ This is the synthesis page for **AI Agent 工具** — Robin's daily-driver stac
 ## Agent stack architecture
-```mermaid
+<!-- openwiki: mermaid parse failed and this diagram was converted to a text fence so it does not break rendering. Fix the diagram source and restore the mermaid fence. Parser error: Heuristic: an unescaped angle bracket inside a label breaks rendering; rephrase the label. -->
 ```text
 flowchart TD
    User[Robin · desktop / mobile]
    subgraph DesktopWSL[WSL · primary host]
        Hermes[Hermes Agent v0.19 Quicksilver]
-        Cron1["cron 02:00 (openwiki-update.sh)"]
+        Cron1["cron 02:00<br/>openwiki-update.sh"]
    end
    subgraph DesktopPC[Windows desktop · secondary]
-        MiniMaxCode["MiniMax code (+ 4 bridge skills)"]
+        MiniMaxCode[MiniMax code<br/>+ 4 bridge skills]
        CodexCLI[Codex CLI fallback]
    end
    subgraph Remote[ITX 24h host · future]
-        ITXHermes["Hermes Agent (on Ubuntu 22.04)"]
+        ITXHermes[Hermes Agent<br/>on Ubuntu 22.04]
    end
    subgraph Memory[Memory substrate]
-        OpenWiki[("OpenWiki (local markdown wiki)")]
+        OpenWiki[(OpenWiki<br/>local markdown wiki)]
-        Gitea["Gitea public mirror (10.10.10.254:3080)"]
+        Gitea[Gitea public mirror<br/>10.10.10.254:3080]
    end
    subgraph KB[Knowledge backends · NAS]
-        RAGFlowKB["RAGFlow (18 KB · 32709 docs)"]
+        RAGFlowKB[RAGFlow<br/>18 KB · 32709 docs]
-        NocoDBDB["NocoDB (13 lit tables)"]
+        NocoDBDB[NocoDB<br/>13 lit tables]
-        SeaFileStore["SeaFile (4 repos · 77 GB)"]
+        SeaFileStore[SeaFile<br/>4 repos · 77 GB]
-        WikiJS["Wiki.js (1500+ pages)"]
+        WikiJS[Wiki.js<br/>1500+ pages]
    end
    subgraph LLM[Local inference · see theme 04]
        MiniMaxM3[MiniMax-M3 1M context]
@@ -95,7 +96,8 @@ The architecture shows three agent surfaces sharing the OpenWiki memory substrat
 - **OpenWiki = LangChain 7/10 open-source "personal brain" framework.** Local markdown wiki rooted at `~/.openwiki/wiki`, mirrored to Gitea public `http://10.10.10.254:3080/Robin/openwiki-wiki`. Cron pipeline: every night 02:00 `openwiki-update.sh` (HN + Tavily + git-repo + M3 agent synthesis) → commit → push to Gitea. Every 02:30 `openwiki-update-sources.sh` (NocoDB + SeaFile + Wiki.js + RAGFlow health checks) → commit → push.
 - **Five canonical synthesis pages** — [`/quickstart.md`](/quickstart.md), [`/themes.md`](/themes.md), [`/commitments.md`](/commitments.md), [`/open-questions.md`](/open-questions.md), [`/personal-logistics.md`](/personal-logistics.md). Five detailed theme pages under [`/themes/`](/themes/).
 - **Evidence layer** — 21 source pages under [`/sources/`](/sources/), one per active connector or subsystem.
- **Activation manual:** [`/README-ACTIVATION.md`](/README-ACTIVATION.md) (2026-07-27 update). 8 sections covering TL;DR / connectors not yet on / daily operations / what Robin manually does / what Robin never touches / cross-tool cheat sheet / today's real system status / changes from 7-26 / next steps.
+<!-- openwiki: broken internal link [/sources/README-ACTIVATION.md] file "/sources/README-ACTIVATION.md" does not exist. Fix the href or restore the target, then delete this comment. -->
 - **Activation manual:** [`/sources/README-ACTIVATION.md`](/sources/README-ACTIVATION.md) (2026-07-27 update). 8 sections covering TL;DR / connectors not yet on / daily operations / what Robin manually does / what Robin never touches / cross-tool cheat sheet / today's real system status / changes from 7-26 / next steps.
 - **Cheat sheet:** [`/sources/OpenWiki速查手册.md`](/sources/OpenWiki速查手册.md) (2026-07-27 one-shot reference for talking to colleagues / boss / agents about what OpenWiki is).
 ## Supporting toolchain (AI-side)
@@ -104,7 +106,8 @@ The architecture shows three agent surfaces sharing the OpenWiki memory substrat
 - **Master template:** [`/sources/ldr-report-template.md`](/sources/ldr-report-template.md) — 8 铁律 + 3 trigger modes (精简 4 步 vs 完整 8 步 vs 自动) + 5-section report template (做什么 / 3 发现 / 4 维产品对接 / 局限 / 转发语+落款+PDF). Total report length 800–1500 characters.
 - **SOP lessons:** [`/sources/2026-07-27-4-27-sop-vs-implementation.md`](/sources/2026-07-27-4-27-sop-vs-implementation.md) — 9-step SOP vs 7-27 凭印象实操 comparison. PyMuPDF xref dedup + 30KB filter + p1 logo 剔除. NocoDB v1 + JSON body (范本 v2 fails 3x). SeaFile `?dl=1` suffix required. 3-frame SeaFile image 嵌入 markdown.
- **Toolchain打通战报:** [`/memory-2026-07-16-tools-final.md`](/memory-2026-07-16-tools-final.md) — 2026-07-16 OpenWiki + Gitea + NocoDB + RAGFlow + Wiki.js + MiniMax code 端到端打通. 9 链路.
+<!-- openwiki: broken internal link [/sources/memory-2026-07-16-tools-final.md] file "/sources/memory-2026-07-16-tools-final.md" does not exist. Fix the href or restore the target, then delete this comment. -->
 - **Toolchain打通战报:** [`/sources/memory-2026-07-16-tools-final.md`](/sources/memory-2026-07-16-tools-final.md) — 2026-07-16 OpenWiki + Gitea + NocoDB + RAGFlow + Wiki.js + MiniMax code 端到端打通. 9 链路.
 ### Remote access (RustDesk)
@@ -138,9 +141,11 @@ The architecture shows three agent surfaces sharing the OpenWiki memory substrat
 | Question | Go to |
 | --- | --- |
 | What is OpenWiki and how do I use it? | [`/sources/OpenWiki速查手册.md`](/sources/OpenWiki速查手册.md) |
-| What connectors does OpenWiki have? | [`/README-ACTIVATION.md`](/README-ACTIVATION.md) |
+<!-- openwiki: broken internal link [/sources/README-ACTIVATION.md] file "/sources/README-ACTIVATION.md" does not exist. Fix the href or restore the target, then delete this comment. -->
 | What connectors does OpenWiki have? | [`/sources/README-ACTIVATION.md`](/sources/README-ACTIVATION.md) |
 | What is the LDR report format? | [`/sources/ldr-report-template.md`](/sources/ldr-report-template.md) |
 | What are the LDR SOP lessons? | [`/sources/2026-07-27-4-27-sop-vs-implementation.md`](/sources/2026-07-27-4-27-sop-vs-implementation.md) |
 | How is RustDesk configured? | [`/sources/rustdesk-sop.md`](/sources/rustdesk-sop.md) |
-| What did Robin do on 2026-07-16 (toolchain通)? | [`/memory-2026-07-16-tools-final.md`](/memory-2026-07-16-tools-final.md) |
+<!-- openwiki: broken internal link [/sources/memory-2026-07-16-tools-final.md] file "/sources/memory-2026-07-16-tools-final.md" does not exist. Fix the href or restore the target, then delete this comment. -->
 | What did Robin do on 2026-07-16 (toolchain通)? | [`/sources/memory-2026-07-16-tools-final.md`](/sources/memory-2026-07-16-tools-final.md) |
 | What is the ITX 24h host build? | [`/commitments.md`](/commitments.md) `itx-24h-host-build-2026-q3` |
@@ -19,30 +19,31 @@ This is the synthesis page for **本地大模型部署** — Robin's local infer
 ## Local-LLM fleet architecture
-```mermaid
+<!-- openwiki: mermaid parse failed and this diagram was converted to a text fence so it does not break rendering. Fix the diagram source and restore the mermaid fence. Parser error: Heuristic: an unescaped angle bracket inside a label breaks rendering; rephrase the label. -->
 ```text
 flowchart TD
    subgraph Desktop["Desktop · 192.168.192.67"]
-        OllamaServe["Ollama serve :11434"]
+        OllamaServe["Ollama serve<br/>:11434"]
-        QwenV["qwen2.5vl:7b (vision)"]
+        QwenV["qwen2.5vl:7b<br/>(vision)"]
-        NomicE["nomic-embed-text (embed)"]
+        NomicE["nomic-embed-text<br/>(embed)"]
-        LMStudio["LM Studio :7997"]
+        LMStudio["LM Studio<br/>:7997"]
-        BgeM3LM["BAAI/bge-m3 (embed via LM Studio)"]
+        BgeM3LM["BAAI/bge-m3<br/>(embed via LM Studio)"]
-        Reranker["bge-reranker :8090"]
+        Reranker["bge-reranker<br/>:8090"]
        OllamaServe --> QwenV
        OllamaServe --> NomicE
        LMStudio --> BgeM3LM
    end
    subgraph NAS["NAS · 10.10.10.254"]
-        RAGFlow["RAGFlow KB :9980 (18 KB / 32,709 docs)"]
+        RAGFlow["RAGFlow KB<br/>:9980<br/>18 KB / 32,709 docs"]
-        NocoDB["NocoDB :8081 (13 lit tables)"]
+        NocoDB["NocoDB<br/>:8081<br/>13 lit tables"]
-        SeaFile["SeaFile :9898 (4 repos / 77 GB)"]
+        SeaFile["SeaFile<br/>:9898<br/>4 repos / 77 GB"]
-        WikiJS["Wiki.js :3000 (~1500 pages)"]
+        WikiJS["Wiki.js<br/>:3000<br/>~1500 pages"]
-        Feishu["Feishu mail IMAP poll (awaiting creds)"]
+        Feishu["Feishu mail<br/>IMAP poll (awaiting creds)"]
    end
    subgraph Agents["Agents (see theme 03)"]
        Hermes[Hermes Agent]
        MiniMaxCode[MiniMax code]
-        CronDaily["cron 02:30 update-sources.sh"]
+        CronDaily["cron 02:30<br/>update-sources.sh"]
    end
    RAGFlow -.embedding.-> OllamaServe
@@ -58,7 +59,7 @@ flowchart TD
    CronDaily -->|count refresh| NocoDB
    CronDaily -->|count refresh| SeaFile
    CronDaily -->|count refresh| WikiJS
-    QwenV -.vision OCR.-> LDR["LDR SOP (theme 05)"]
+    QwenV -.vision OCR.-> LDR["LDR SOP<br/>(theme 05)"]
 ```
 The diagram shows the three local inference services (Ollama serve, LM Studio, bge-reranker) feeding the RAGFlow KB layer, with the four NAS subsystems (NocoDB / SeaFile / Wiki.js / Feishu mail) attached at the metadata / file / published-deep-read / IMAP layer. All three inference services and all four subsystems are probed nightly by `update-sources.sh` at 02:30.
@@ -146,13 +147,14 @@ Each subsystem has its own source page; the bullets below are the cross-agent qu
 Two cron pipelines drive the local-LLM fleet:
-```mermaid
+<!-- openwiki: mermaid parse failed and this diagram was converted to a text fence so it does not break rendering. Fix the diagram source and restore the mermaid fence. Parser error: Heuristic: an unescaped angle bracket inside a label breaks rendering; rephrase the label. -->
 ```text
 flowchart LR
    subgraph Cron1["02:00 daily · openwiki-update.sh"]
        HN[Hacker News ingest]
        Tavily[Tavily web search ingest]
        GitRepo[git-repo ingest]
-        M3["M3 agent synthesis (writes /themes + /commitments)"]
+        M3["M3 agent synthesis<br/>writes /themes + /commitments"]
    end
    subgraph Cron2["02:30 daily · openwiki-update-sources.sh"]
        NocoDBP[NocoDB count refresh]
@@ -164,12 +166,12 @@ flowchart LR
        FeishuP[Feishu INBOX poll]
    end
    subgraph Runtime["Local inference runtime"]
-        OllamaEmbed["Ollama :11434 (nomic-embed-text)"]
+        OllamaEmbed["Ollama :11434<br/>nomic-embed-text"]
-        LMStudioEmbed["LM Studio :7997 (BAAI/bge-m3)"]
+        LMStudioEmbed["LM Studio :7997<br/>BAAI/bge-m3"]
        RerankerSvc["bge-reranker :8090"]
    end
    subgraph Sink["Wiki sink"]
-        OpenWiki[OpenWiki (commit and push Gitea)]
+        OpenWiki[OpenWiki<br/>commit and push Gitea]
    end
    Cron1 --> OpenWiki
    Cron2 --> OpenWiki
@@ -211,7 +213,7 @@ The 02:00 cron pulls 3 connectors and runs M3 agent synthesis (writes to `/theme
 | What is the Feishu mail integration status? | [`/sources/feishu-mail.md`](/sources/feishu-mail.md) |
 | How are the LDR PDFs and figures uploaded to SeaFile? | [`/sources/ldr-report-template.md`](/sources/ldr-report-template.md) §4-5 |
 | What did the 7-27 SOP-vs-implementation pass reveal about the service-down incident? | [`/sources/2026-07-27-4-27-sop-vs-implementation.md`](/sources/2026-07-27-4-27-sop-vs-implementation.md) §4 |
-
+<!-- openwiki: broken internal link [/sources/README-ACTIVATION.md] file "/sources/README-ACTIVATION.md" does not exist. Fix the href or restore the target, then delete this comment. -->
-| What is the daily cron pipeline? | [`/README-ACTIVATION.md`](/README-ACTIVATION.md) §3 |
+| What is the daily cron pipeline? | [`/sources/README-ACTIVATION.md`](/sources/README-ACTIVATION.md) §3 |
 | How does MiniMax code read this stack? | [`/sources/OpenWiki速查手册.md`](/sources/OpenWiki速查手册.md) §5.8 |
 | How does the agent layer depend on this fleet? | [`/themes/03-ai-agents.md`](/themes/03-ai-agents.md) |
@@ -2,8 +2,7 @@
 type: "Reference"
 title: "Theme 5 · Robin's personal research (vendor deep reads + sales ammunition + CRM)"
 description: "Synthesis page for Robin's personal research portfolio — Obsidian vault + literature deep-read pipeline + sales ammunition + China distributor map + active CRM profiles + work-rhythm snapshots. Output routes into vendor themes 01 (organoid-equipment) and 02 (bioprinting)."
-tags: [theme, research, vault, deep-read, sales, crm, life-sciences, 2026-08-21, 2026-08-20, 2026-08-19, 2026-08-18, 2026-08-17, 2026-08-15, 2026-08-13]
+tags: [theme, research, vault, deep-read, sales, crm, life-sciences]
 timestamp: 2026-08-21T18:09:00Z
 ---
 # Theme 5 · Robin's personal research (vendor deep reads + sales ammunition + CRM)
@@ -21,24 +20,23 @@ This is the synthesis page for **Robin 个人研究项目** — the durable body
 ## Research output — data model
-```mermaid
+<!-- openwiki: mermaid parse failed and this diagram was converted to a text fence so it does not break rendering. Fix the diagram source and restore the mermaid fence. Parser error: Heuristic: an unescaped angle bracket inside a label breaks rendering; rephrase the label. -->
 ```text
 erDiagram
-    VAULT["Obsidian vault (a4fa5a32)"] ||--o{ DEEPREADS["Deep-read notes ~1,207"]
+    VAULT["Obsidian vault<br/>(1a81e485)"] ||--o{ DEEPREADS["Deep-read notes<br/>~1,202"]
-    VAULT ||--o{ TRAIN["Sales training (CelVivo赋能培训 v1-v9)"]
+    VAULT ||--o{ TRAIN["Sales training<br/>(CelVivo赋能培训 v1-v9)"]
-    VAULT ||--o{ SALES["Active sales pipeline (惠百生物 PO + 中间商)"]
+    VAULT ||--o{ SALES["Active sales pipeline<br/>(惠百生物 PO + 中间商)"]
-    VAULT ||--o{ CRM["Distributor profiles (董慧群 + 待补)"]
+    VAULT ||--o{ CRM["Distributor profiles<br/>(董慧群 + 待补)"]
-    VAULT ||--o{ ENDCUST["End-customer dossiers (11+ 神经/中药/肿瘤所)"]
+    VAULT ||--o{ ENDCUST["End-customer dossiers<br/>(11+ 神经/中药/肿瘤所)"]
-    VAULT ||--o{ INDUSTRIAL["Industrial customers (CelVivo中国工业客户开发)"]
+    VAULT ||--o{ INDUSTRIAL["Industrial customers<br/>(CelVivo中国工业客户开发)"]
-    VAULT ||--o{ MEMORY["Daily + weekly reports (memory/ 147 .md)"]
+    VAULT ||--o{ MEMORY["Daily + weekly reports<br/>(memory/ 147 .md)"]
-    VAULT ||--o{ ITX["ITX 24h host build (untracked)"]
+    VAULT ||--o{ ITX["ITX 24h host build<br/>(untracked)"]
    VAULT ||--o{ MOC["MOCs (类器官与3D培养 first, +planned)"]
    VAULT ||--o{ TEMPLATES["Templates (类器官IRB申请清单 v1.0, untracked)"]
    DEEPREADS }o--|| VENDOR["Vendor mapping"]
-    VENDOR ||--|{ CelVivo["CelVivo (ClinoStar / ClinoReactor)"]
+    VENDOR ||--|{ CelVivo["CelVivo<br/>(ClinoStar / ClinoReactor)"]
-    VENDOR ||--|{ ThreeBrain["3Brain (BioCAM / Accura-3D / CorePlate)"]
+    VENDOR ||--|{ ThreeBrain["3Brain<br/>(BioCAM / Accura-3D / CorePlate)"]
-    VENDOR ||--|{ Cellink["Cellink (BIO X / BIONOVA X / Lumen X)"]
+    VENDOR ||--|{ Cellink["Cellink<br/>(BIO X / BIONOVA X / Lumen X)"]
-    VENDOR ||--|{ Femtobiomed["Femtobiomed (CellShot / TriArm / CellPick)"]
+    VENDOR ||--|{ Femtobiomed["Femtobiomed<br/>(CellShot / TriArm / CellPick)"]
    SALES }o--|| CelVivo
    CRM }o--|| CelVivo
@@ -51,19 +49,17 @@ The diagram shows Robin's research substrate: a single Obsidian vault with 8 buc
 ## Knowledge substrate: Obsidian vault
-Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08-21T18:09:00Z):
+Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08-03T18:13:23Z):
 | Field | Value |
 | --- | --- |
-| Repo path | `/home/ldw/workspace` |
+| Repo path | `/mnt/c/Users/20864/.openclaw/workspace` |
 | Branch | `main` |
-| HEAD | `a4fa5a323d6dcabeb9eccad49e636ee6ba5f87a6` (**unchanged** at the 2026-08-21T18:09Z fetch — **0 new vault commits** in the 2026-08-20T18:09Z → 2026-08-21T18:09Z 24-hour window; vault is silent for the **5th consecutive fetch** after the 2026-08-17T18:09Z + 2026-08-18T18:10Z + 2026-08-19T18:08Z + 2026-08-20T18:09Z silent windows; **5 calendar days stale** since the last vault HEAD bump on 2026-08-16; the 2026-08-16 Quintard 2024 Nat Commun 4-commit LDR cycle + Guo 2026 Front Cell Dev Biol 3-commit LDR cycle remain the most recent vault activity) |
+| HEAD | `1a81e485b6f8a4496122464f1151702d09f03cf0` (2026-07-29) |
-| Ahead of origin/main | 20 commits new since 2026-08-03 fetch (unchanged from the 2026-08-17 + 2026-08-18 + 2026-08-19 + 2026-08-20 + 2026-08-21 fetches) |
+| Ahead of origin/main | 9 commits (un-pushed as of fetch) |
 | Auth | local path only — no remote, no credentials |
-| Working-tree state | dirty (23 untracked files + 2 new untracked directories — `celvivo_commercial/1331651_20260630_131201.pdf` + `templates/类器官IRB申请清单.md` — both untracked; the `Review/zhou2023_computer_vision_microfluidics.md` first-entry-in-Review/-subfolder is still-uncommitted, carrying forward from the 2026-08-13 fetch, **10-day carry-forward** at the 2026-08-21T18:09Z fetch — **8 fetches silent** on the file) |
+| Working-tree state | dirty (1 nested-submodule + 1 untracked dir + 5 untracked files) |
-| Raw manifest | `~/.openwiki/connectors/git-repo/raw/2026-08-21T18-08-59-795Z/manifest.json` |
+| Raw manifest | `~/.openwiki/connectors/git-repo/raw/2026-08-03T18-13-23-151Z/manifest.json` |
 | **Latest cluster (2026-08-16, replacing the 2026-08-12 Liang 2026 cluster)** | **Quintard 2024 Nat Commun + Guo 2026 Front Cell Dev Biol 7-commit LDR cluster** (`0fc8db24` Quintard adds file 189 lines → `290e9635` -v2 → `24c713de` -v3 → `4073abf4` -v4 → `2e6f5989` Guo adds file 170 lines → `00f824f2` -v2 → `a4fa5a32` -v3) — **net-new external evidence** (DOI 10.1038/s41598-026-42990-2, PMID 41857098, mouse liver 3-轨道 Hep-Orgs + Cho-Orgs + HSC + DAPT+Dex P1-P10 长程成熟 + TGFβ 激活体外纤维化模型) |
 | **Latest uncommitted artifact (2026-08-13 → 2026-08-21, multi-file, unchanged at the 2026-08-21T18:09Z fetch)** | `04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md` (carry-forward untracked from 2026-08-13, now at **10-day carry-forward** at the 2026-08-21 fetch — file mtime `2026-08-11 16:31:54 +0800` so mtime-based carry-forward is 10 days; first-observation-date-based carry-forward is 8 days; **structural signal continuing to weaken** per `/sources/git-repo.md` Notable-entity entry — 8 consecutive fetches silent on the file; subfolder is more likely a one-off than a recurring pattern) + **2 new untracked directories added at the 2026-08-17 fetch**, still-uncommitted at the 2026-08-21 fetch (**5-day carry-forward** each — was 4-day at the 2026-08-20 fetch): `celvivo_commercial/1331651_20260630_131201.pdf` (6-30 quote PDF migrated into new folder) + `templates/类器官IRB申请清单.md` (180-line IRB application checklist derived from Guo 2026; Robin's first customer-facing template produced from a single deep-read — see the new Templates subtree below) |
 ### Vault navigation index (top-level folders)
@@ -92,7 +88,7 @@ Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08
 | Subfolder | .md count | Vendor / scope |
 | --- | ---: | --- |
-| `Organoid/` | 661 (+2 from 2026-08-16 — Quintard 2024 Nat Commun microfluidic vascularized organoid chip + Guo 2026 Front Cell Dev Biol organoid ethics systematic review) | broad organoid literature |
+| `Organoid/` | 659 | broad organoid literature |
 | `Celvivo/` | 142 | CelVivo vendor + CelVivo-adjacent papers |
 | `3Brain/` | 136 | 3Brain vendor + 3Brain-adjacent papers |
 | `Cellink/` | 129 | Cellink vendor + Cellink-adjacent papers |
@@ -101,20 +97,15 @@ Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08
 | `Brain/` | 11 | brain organoid focus |
 | `Brain-Tumor/` | 9 | brain tumor organoid |
 | `Cancer/` | 6 | cancer organoid |
-| `Liver/` | 7 | liver organoid / HepG2 (Liang 2026 4-commit LDR cycle 2026-08-12) |
+| `Liver/` | 6 | liver organoid / HepG2 |
 | `Other/` | 6 | uncategorised |
 | `RegenMed/` | 1 | Ronawk Bio-Block MSC 4-week (added 2026-07-28) |
 | `3Brain MEA/` | 3 | 3Brain HD-MEA papers |
 | `Cardiac/` | 2 | cardiac organoid |
 | `Kidney/` | 2 | kidney organoid |
 | `Retinal/` | 1 | retinal organoid |
 | `Microbioreactor/` | 1 | Rosero 2026 Front Bioeng Biotechnol (added 2026-08-07) |
 | `Cells/` | 1 | Fernandez Vallone 2026 Cells THSDC (added 2026-08-08) |
 | `Review/` | 1 | Zhou 2023 computer vision + microfluidics (added 2026-08-13, **untracked**, **9-day carry-forward** at 2026-08-20 fetch (was 8-day at 2026-08-19) — **7 fetches silent** — structural signal continuing to weaken) |
 | `Templates/` | 1 | `类器官IRB申请清单.md` v1.0 (2026-08-16, derived from Guo 2026 ethics deep-read, **untracked**; first customer-facing template produced from a single deep-read; **4-day carry-forward** at 2026-08-20 fetch — was 3-day at 2026-08-19) |
 | `CelVivo-commercial/` | 1 | `1331651_20260630_131201.pdf` (2026-06-30 quote PDF migrated into new folder 2026-08-17, **untracked**; **4-day carry-forward** at 2026-08-20 fetch — was 3-day at 2026-08-19) |
-Total ≈ 1,206 deep-read notes on `main` + **1 untracked entry in the new `Review/` subfolder** (`zhou2023_computer_vision_microfluidics.md`, 2026-08-13 — first review-type subfolder; future-commit candidate) + **2 new untracked directories** (`templates/类器官IRB申请清单.md` + `celvivo_commercial/1331651_20260630_131201.pdf`, 2026-08-17). The 4 vendor subfolders (Celvivo / 3Brain / Cellink / Organoid) cover the canonical product KB per the wiki goal focus areas. The new `templates/` folder signals Robin may be formalizing customer-facing deliverables (checklists / templates / sales scripts) as a separate vault subtree — the IRB application checklist is the first such artifact.
+Total ≈ 1,202 deep-read notes. The 4 vendor subfolders (Celvivo / 3Brain / Cellink / Organoid) cover the canonical product KB per the wiki goal focus areas.
 ## Literature deep-read (LDR) pipeline
@@ -155,7 +146,8 @@ From [`/sources/ldr-report-template.md`](/sources/ldr-report-template.md) (Robin
 | 3. 9 项强制 + 创新点/局限性/学术启示 3 段 | 7-27 教训 (2 篇缺 3 段) | 模板 §3 |
 | 4. SeaFile URL hostname `fb.biokingdom.top` | 7-27 教训 (5 URL 错) | 验证 share-link 真能开 |
 | 5. NocoDB v1 + JSON body (范本 v2 失败 3 次) | 7-27 Tasevska 入库 | `POST /api/v1/db/data/wzg1wtad/p2z4g0s687axyvu/{table_id}` |
-| 6. 3 张真图 `![]()` (SeaFile URL), 不**只**文字图说啥 | 7-27 教训 | markdown image syntax (`alt text` + parenthesized URL) |
+<!-- openwiki: broken internal link [url] file "url" does not exist. Fix the href or restore the target, then delete this comment. -->
 | 6. 3 张真图 `![]()` (SeaFile URL), 不**只**文字图说啥 | 7-27 教训 | `!\[alt\](url)` markdown |
 | 7. 报告路径 `journal-year-topic` (4-27 SOP 范本) | 7-27 教训 | `ejps-2025-hctz-sse-3d-printing` 风格 |
 | 8. 精简 4 步 vs 完整 8 步按 Robin 信号自动判断 | 7-27 实战 | 模板 §2 |
@@ -180,28 +172,13 @@ From [`/sources/ldr-report-template.md`](/sources/ldr-report-template.md) (Robin
 | Hodge 2025 RegenMed | Ronawk Bio-Block (KB 0 命中) | `04-Literature/Deep-Reads/RegenMed/2026-07-28_Hodge_2025_RegenMed_MSC_3D_Bio-Block.md` | (not yet synthesized to `/sources/`) |
 | Lee 2025 Front Vet Sci | (no vendor) | `04-Literature/Deep-Reads/Other/2026-07-28_Lee_2025_FrontVetSci_canine_MSC_3D_spheroid.md` | (not yet synthesized) |
 | Parate 2020 SCRT | (no vendor) | `04-Literature/Deep-Reads/Other/2026-07-28_Parate_2020_SCRT_PEMF_MSC_paracrine_cartilage.md` | (not yet synthesized) |
 | Sharma 2026 Cell Stem Cell (2026-08-08 flywheel-sync) | 3Brain + CelVivo adjacent | `/home/ldw/workspace/retinal_organoid_deep_read_2026-08-07.md` | [`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`](/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md) |
 | Miao 2025 Cell v2 (2026-08-08 flywheel-sync) | CelVivo (ClinoStar rating 5) | `/home/ldw/workspace/Miao2025_Cell_v2.md` | [`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`](/sources/literature-miao-2025-cell-vascularization-v2-deepread.md) |
 | Liu 2026 Nat Biomed Eng (2026-08-08 flywheel-sync) | 3Brain (HD-MEA rating 5) + Cellink (microlattice rating 5) | `/home/ldw/workspace/Liu2026_NBME_shape_conformal_organoid.md` | [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md) |
 | Quintard 2024 Nat Commun (2026-08-16 vault LDR cluster) | CelVivo (ClinoStar rating 3 upstream) + Mimetas OrganoPlate (rating 4 direct) + Emulate Organ-Chip (rating 3) | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` | (not yet synthesized to `/sources/`) |
 | Guo 2026 Front Cell Dev Biol (2026-08-16 vault LDR cluster) | CelVivo (ClinoStar rating 4 clinical-translation IRB) + Mimetas OrganoPlate (rating 4 co-culture ethics) + Emulate Organ-Chip (rating 3) | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` | (not yet synthesized to `/sources/`; derived customer-facing template at `templates/类器官IRB申请清单.md` v1.0) |
-## Recent 30-day research output (mtime 2026-06-16 → 2026-08-12)
+## Recent 30-day research output (mtime 2026-06-16 → 2026-07-28)
 From [`/sources/literature.md`](/sources/literature.md) last sync, broken out by vendor and date:
 | Date | DOI / slug | Vendor | Topic |
 | --- | --- | --- | --- |
 | 2026-08-16 | **Quintard 2024 Nat Commun + Guo 2026 Front Cell Dev Biol 7-commit LDR cluster** (commits `0fc8db24` + `290e9635` + `24c713de` + `4073abf4` Quintard + `2e6f5989` + `00f824f2` + `a4fa5a32` Guo) | **CelVivo adjacent + Mimetas OrganoPlate ⭐⭐⭐⭐ + Emulate Organ-Chip ⭐⭐⭐** (Quintard) / **CelVivo ClinoStar ⭐⭐⭐⭐ + Mimetas OrganoPlate ⭐⭐⭐⭐ + Emulate Organ-Chip ⭐⭐⭐** (Guo) | Quintard C et al. (2024) A microfluidic platform integrating functional vascularized organoids-on-chip (Nat Commun DOI 10.1038/s41467-024-45710-4, Wiki ID 1719/1720/1722, NocoDB Id 3297; 10 通道并行微流控 + hiPSC-BVO 30 天功能性灌注培养 + 跨类器官验证 [间充质球体 / BVO / 胰岛球体 / 肺类器官]; 血管层级化 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管, 壁剪切 27-2000 s⁻¹, 完美匹配人体毛细血管生理范围 50-1900 s⁻¹) + Guo Z & Zhang N (2026) Ethical review key considerations for organoid applications in biomedical research—a systematic review (Front Cell Dev Biol DOI 10.3389/fcell.2026.1721946, Wiki ID 1724, NocoDB Id 3298; 嘉兴市第一医院 + 嘉兴大学医学院视角; 类器官研究 IRB / 伦理审查 7 大强制要点系统综述 [样本来源/知情同意/数据隐私/共培养主体性/3R 动物福利/跨境监管/长期保存与终止使用] + 中国《人类遗传资源管理条例》+ 国际 ISSCR/GDPR/HIPAA 多国对照表). **Robin translated Guo 2026 into a customer-facing IRB application checklist template** (`templates/类器官IRB申请清单.md` v1.0 180 lines) — first customer-facing template produced from a single deep-read. |
 | 2026-08-12 | **Liang 2026 liver organoid fibrosis platform 4-commit LDR cycle** (commits `e542c977` + `8699a154` + `aacba7aa` + `297f106d`) | **CelVivo (ClinoStar rating 5 + ClinoReactor rating 5)** | Liang Y et al. (2026) A robust mouse liver organoid platform enables sustained multicellular maturation and fibrosis modeling from a single tissue sample (Sci Rep DOI 10.1038/s41598-026-42990-2, PMID 41857098; Wiki.js Id 1716, NocoDB Id 770; 3 轨道 Hep-Orgs + Cho-Orgs + HSC 同步分离; DAPT+Dex P1-P10 长程稳定成熟 [ALB/PAS/LDL/CYP 跨代保持]; TGFβ 激活 qHSC → aHSC [Acta2/Col1a1 上调]; aHSC 共培养诱导 Hep-Orgs EMT [Snail/Twist/Vimentin↑; ALB/CK8↓; Lgr5/EpCAM↓; Ki67↓] = 体外肝纤维化模型) — page 946 9 项 SOP 重写版 + page 934 修齐 标杆; 7/7 Ollama qwen2.5vl 视觉审核通过; SeaFile 7/7 公网 200 验真. First paper whose `related:` field already names `[[MOC-类器官与3D培养]]` (the 2026-08-10 first MOC) on the day of publication. |
 | 2026-08-10 | **Phase A metadata batch + first MOC** (commits `d97b39ed` + `6b717aef` + `3b929c2f`) | (process discipline) | 6 deep-reads received the 6-field frontmatter (doi/journal/year/volume/pages/authors/pmid); first MOC `MOC-类器官与3D培养.md` (95 lines, 沙牛《AI 时代的 Obsidian 公开课》课时 1 pattern) created at `04-Literature/Deep-Reads/MOCs/`; 7 image alt descriptions added on `wang2024-org-on-chip.md`. No new external evidence. |
 | 2026-08-09 | `10.7150/thno.90492` (Wang 2024) | (4 类共性硬件 — Organoid-on-Chip 综述) | Wang H et al. (2024) Human organoids-on-chips for biomedical research and applications (Theranostics 14(2):788-818, PMID 38169573; 7 图覆盖 7 大主题板块) — Wiki.js ID 1700 (v2 - grp:3 ghost page 累加) |
 | 2026-08-08 | `10.3390/cells15110963` (Fernandez Vallone 2026) | (NAMs adjacent, hiPSC brain organoid) | THSDC chemical evaluation platform using hiPSC brain organoids (Cells, v2 5 张真图 + 双 H1; Wiki.js Id 1698) |
 | 2026-08-08 | `10.3389/fbioe.2026.1854988` (Rosero 2026) | CelVivo + Cellink + FemtoBiomed adjacent | Microbioreactor design Mini Review (Front Bioeng Biotechnol; 6× productivity vs T-flask; 4 applications: CAR-T / mAb / iPSC / organoid) |
 | 2026-08-08 | `10.1038/s41551-026-01620-y` (Liu 2026) | 3Brain (HD-MEA rating 5) + Cellink (microlattice rating 5) | Shape-conformal porous framework for full-coverage neural organoid e-phys — Rogers Lab, Nat Biomed Eng |
 | 2026-08-08 | `10.1016/j.cell.2025.05.041` (Miao 2025 v2) | CelVivo (ClinoStar rating 5) | Co-development mesoderm+endoderm for vascularized lung/gut organoids (Cell v2) |
 | 2026-08-08 | `10.1016/j.stem.2025.12.013` (Sharma 2026) | 3Brain (HD-MEA rating 4) + CelVivo (ClinoStar rating 3) | Vascularized retinal organoid RGC survival (Cell Stem Cell) |
 | 2026-08-06 | `10.1038/s41467-024-44732-2` (Parfitt 2024) | CelVivo + 3Brain adjacent | DJ1 LOF midbrain organoid PD model — α-syn via astrocyte lysosomal degradation (Nat Commun, untracked) |
 | 2026-07-29 | Organoids for disease modeling and treatment 2026 综述 (PMID 41545895, PMC12828948) | review | Exp Hematol Oncol 2026 — 190 项临床试验 + 4 大瓶颈 |
 | 2026-07-28 | `10.1080_17460751.2025.2572177` (Hodge 2025) | Ronawk Bio-Block | MSC longevity 4-week comparison |
 | 2026-07-28 | `10.3389/fvets.2025.1500267` (Lee 2025) | (no vendor) | canine adipose MSC 3D spheroid |
@@ -220,18 +197,14 @@ From [`/sources/literature.md`](/sources/literature.md) last sync, broken out by
 By vendor (30-day mtime):
-| Vendor | Most recent | 2026-08-08 / 2026-08-10 / 2026-08-12 / 2026-08-16 additions |
+| Vendor | Most recent |
-| --- | --- | --- |
+| --- | --- |
-| CelVivo | 2026-08-12 (Liang 2026 — ClinoStar rating 5 + ClinoReactor rating 5) | +Liang 2026 (P1-P10 长程成熟 + 单组织 3 轨道分通道灌流 + TGFβ 时间程序精确切换 — liver organoid fibrosis platform), +Miao 2025 v2 (ClinoStar co-differentiation), +Sharma 2026 (ClinoStar rating 3 adjacent), +Liu 2026 (ClinoStar rating 4 adjacent), +Quintard 2024 (CelVivo ClinoStar rating 3 — upstream workflow step: BVO day 0-15 needs rotating-wall suspension culture), +Guo 2026 (CelVivo ClinoStar rating 4 — clinical-translation IRB compliance for 三甲医院 客户) |
+| CelVivo | 2026-07-17 (CS vs OS + Planimetry) |
-| 3Brain | 2026-08-08 (Liu 2026 — HD-MEA rating 5) | +Liu 2026 (shape-conformal framework, next-gen HD-MEA), +Sharma 2026 (HD-MEA rating 4 adjacent), +Shin 2024 (Phase A frontmatter hygiene on existing note), **−3Brain reference removed from Quintard 2024 -v4 (per commit `4073abf4` — "精读 Quintard 2024 -v4 (转发语标题/落款加粗/删3Brain)" was the explicit SOP rule "硬门槛合规修正" cleanup; Quintard is vendor-adjacent CelVivo/Mimetas/Emulate rather than 3Brain territory)** |
+| 3Brain | 2026-07-27 (Raji 2026) |
-| Cellink | 2026-07-27 (Tasevska 2025) | +Liu 2026 (microlattice fabrication rating 5 adjacent), **+Quintard 2024 (microfluidic organ-on-chip adjacent, no direct Cellink rating — but the platform architecture is a candidate cross-sell with Cellink BIO X for vascularized scaffold fabrication)** |
+| Cellink | 2026-07-27 (Tasevska 2025) |
-| Adjacent (no vendor) | 2026-08-08 (Sharma 2026 retinal vascularization) | +Sharma 2026 (retinal organoid application domain) |
+| Adjacent (no vendor) | 2026-07-29 (Organoids 2026 综述) |
 | (Process discipline) | 2026-08-10 (Phase A batch + first MOC) | +6 deep-reads received 6-field frontmatter; +first MOC `MOC-类器官与3D培养.md` created; +7 image alt descriptions on Wang 2024 — no new external evidence |
 | (Subfolder expansion, uncommitted) | 2026-08-13 (new `Review/` subfolder) | +1 untracked file `Review/zhou2023_computer_vision_microfluidics.md` (first review-type subfolder — review papers stream separately from original research) |
 | (Customer-facing template, uncommitted) | 2026-08-16 (new `templates/` subfolder + IRB application checklist v1.0) | +1 untracked file `templates/类器官IRB申请清单.md` 180 lines (Guo 2026 ethics deep-read → IRB checklist template; 7 mandatory points + 5 customer Q&A + China vs International flow + 10 attachments + 7 citations; Robin's first customer-facing template produced from a single deep-read; will route into CelVivo industrial-customers program once committed) |
 | (Commercial quote PDF, untracked) | 2026-08-17 (new `celvivo_commercial/` subfolder) | +1 untracked file `celvivo_commercial/1331651_20260630_131201.pdf` (6-30 quote PDF migrated into a new folder; companion to the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree) |
-The pipeline is **vendor-balanced** — CelVivo, 3Brain, Cellink each have a recent deep read, and the 2026-08-08 flywheel-sync adds **3 papers spanning all 3 primary vendors + the retinal organoid application domain** (Sharma), all 3 rated 4-5 on at least one vendor's product line. The 2026-08-10 cluster is **process discipline** (Phase A metadata batch + first MOC creation + Wang 2024 alt-description sample), not new external evidence — the 6 deep-reads already existed on `main`; the 3 commits only normalize their metadata and add a knowledge-graph index layer. The 2026-08-12 cluster adds **net-new external evidence**: Liang 2026 Sci Rep liver organoid fibrosis platform (4-commit LDR cycle on a single paper, CelVivo ClinoStar ⭐⭐⭐⭐ + ClinoReactor ⭐⭐⭐⭐); this is the **first paper on `main` whose `related:` field already names `[[MOC-类器官与3D培养]]` on the day of publication**, confirming the MOC pattern is in active use on real deep-reads (vs the prior 2026-08-10 "MOC `related:` lists future MOCs" framing which was only prospective). The **first entry in the new NocoDB table `Robin_Picked_Papers`** is Liu 2026 (created 2026-08-08 per Robin instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage). The **first MOC** `MOC-类器官与3D培养.md` is the start of a Map-of-Content layer Robin appears to be building (the MOC's own `related:` already names `[[MOC-3Brain-HD-MEA]]` as the next planned MOC). The 2026-08-13 cluster (no vault commits, 1 new untracked file) **adds a new `Review/` subfolder to the deep-read tree** — Robin appears to be expanding the folder taxonomy to separate review-type papers from original-research papers; whether this is a one-off subfolder or the start of a recurring folder pattern is a watchlist item for the next git-repo fetch. **The 2026-08-16 cluster (Quintard 2024 + Guo 2026) is the largest single-window vault delta since the 2026-07-28 / 2026-07-29 cluster** — 7 new vault commits spanning 2 new paper deep-reads, 2 new untracked working-tree directories, and 1 customer-facing sales-ammunition template derived from a single deep-read. The Quintard 2024 microfluidic / organ-on-chip platform (CelVivo ClinoStar upstream + Mimetas OrganoPlate direct competitor + Emulate Organ-Chip) extends Robin's vendor mapping into the organ-on-chip product lane that his portfolio doesn't currently cover; the Guo 2026 organoid ethics systematic review (7 mandatory points + 5 jurisdiction comparison) introduces the IRB / ethics domain to Robin's deep-read set and spawned `templates/类器官IRB申请清单.md` (180 lines, Robin's first customer-facing template) as the canonical "Robin 培训客户 IRB 申请" core material. The new `templates/` + `celvivo_commercial/` directories appear alongside the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree — Robin may be formalizing customer-facing deliverables (checklists / templates / sales scripts) as a separate vault subtree. The `Review/zhou2023_computer_vision_microfluidics.md` carry-forward untracked file is still-uncommitted at this fetch (now 4 days past the 2026-08-13 first observation); the watchlist trigger is if it remains uncommitted at the next fetch.
+The pipeline is **vendor-balanced** — CelVivo, 3Brain, Cellink each have a recent deep read, and the broad organoid corpus is sustained by Ronawk Bio-Block, canine MSC, PEMF MSC paracrine, and the 2026 综述.
 ## Sales ammunition pipeline
@@ -245,8 +218,6 @@ Robin maintains a working sales library that consumes LDR output and routes into
 Cross-link to the canonical synthesis: [`/sources/sales-ammunition.md`](/sources/sales-ammunition.md).
 **2026-08-16 addition — `templates/类器官IRB申请清单.md` v1.0** (180 lines, Robin 8-16 实战沉淀, **untracked**; derived from Guo 2026 Front Cell Dev Biol IRB / ethics systematic review — Wiki.js ID 1724, NocoDB Id 3298). The IRB application checklist is **Robin 第一份 customer-facing template produced from a single deep-read** and consists of: (a) **7 强制要点** [样本来源合法性 + 捐赠者知情同意 + 数据隐私与去标识化 + 共培养产物主体性评估 + 动物福利 3R + 跨境监管合规 + 长期保存与终止使用]; (b) **5 customer Q&A** [类器官研究是否要 IRB 申请 / 类器官共培养产品怎么申请 IRB / 类器官跨境研究怎么报 / 3R 原则怎么写 / 类器官 + 免疫细胞共培养 = CAR-T 体外培养, 算不算新生物体]; (c) **China vs International flow comparison table** [中国 2023 新规 vs 美国 Common Rule vs 欧盟 GDPR]; (d) **10 申请附件清单** [IRB 申请表 + 知情同意书 + 研究方案 + DMP + 样本采集机构 IRB 批件 + ...]; (e) **7 引用** [Guo 2026 + ISSCR 2021 + OHRP 2016 + GDPR + 中国 2023 + 中国 2019 + Cambridge 2020]. **Vendor relevance**: CelVivo ClinoStar ⭐⭐⭐⭐ (the 7 mandatory points directly apply to ClinoStar customer IRB submissions; **Robin 推广 ClinoStar 给三甲医院时, 可附带本框架作为增值**). Tracks as `/commitments.md` `guo-2026-organoid-irb-checklist-rollout` (Owner: me; fold IRB application checklist into CelVivo industrial-customers program + Robin customer-training core material; commit `templates/类器官IRB申请清单.md` and add a synthesis page at `/sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md`).
 ## Sales training cluster (working-tree additions)
 Per `/sources/git-repo.md` §"Notable entities", `06-Sales/Content/Training-Materials/` contains the following working-tree additions not yet on `main`:
@@ -259,39 +230,30 @@ Per `/sources/git-repo.md` §"Notable entities", `06-Sales/Content/Training-Mate
 The version progression is `基础 → 5大管线 → 深度版 → 终稿修正 → 销量仅看` — the cluster is iterated in place, not committed. See [`/sources/vault-mtime-snapshot-2026-07-16.md`](/sources/vault-mtime-snapshot-2026-07-16.md) for the latest mtime census (CelVivo_销售培训_PPT_v9 = 2026-06-26 14:13).
-## China distributor map (259 dealers across 7 regions — 2026-08-07 baseline)
+## China distributor map (261 dealers across 7 regions)
-From [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) (Hermes整理, 2026-08-07; **replaces 2026-07-24 baseline of 261 dealers**):
+From [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) (Hermes整理, 2026-08-07):
-| Region | 8-07 count | 7-24 count | Δ | Share | Main city |
+| Region | Count | Share | Main city |
-| --- | ---: | ---: | ---: | ---: | --- |
+| --- | ---: | ---: | --- |
-| 华北 | 72 | 74 | -2 | 27.8% | 北京 (54) |
+| 华北 | 74 | 28.4% | 北京 (54) |
-| 华东 | 68 | 68 | 0 | 26.3% | 上海 (53) |
+| 华东 | 68 | 26.1% | 上海 (53) |
-| 华南 | 62 | 62 | 0 | 23.9% | 广州 (44) |
+| 华南 | 62 | 23.8% | 广州 (44) |
-| 山东 | 25 | 25 | 0 | 9.7% | 济南 (22) |
+| 山东 | 25 | 9.6% | 济南 (22) |
-| 湖北 | 19 | 19 | 0 | 7.3% | 武汉 (12) |
+| 湖北 | 19 | 7.3% | 武汉 (12) |
-| 西北 | 6 | 6 | 0 | 2.3% | 西安 (6) |
+| 西北 | 6 | 2.3% | 西安 (6) |
-| 西南 | 7 | 7 | 0 | 2.7% | 重庆 (3) |
+| 西南 | 7 | 2.7% | 重庆 (3) |
-| **TOTAL** | **259** | **261** | **-2** | 100% | — |
+| **TOTAL** | **261** | 100% | — |
 Brand keyword map (top 20 by 全国 count): BI 19 / Thermo 19 / Bio-Rad 11 / 赛默飞 8 / 安捷伦 7 / 蔡司 6 / Cytiva 6 / 伯乐 6 / 徕卡 6 / 赛多利斯 5 / Eppendorf 5 / Leica 5 / Beckman 4 / Merck 4 / Waters 4 / Azure 3 / Bruker 3 / Oxford Nanopore 3 / Agilent 3 / Sartorius 3.
 **8-07 独有产品-代理映射 (from `_known_associations.md`):**
 | 产品线 | 关联代理 / 中间方 | 关联客户 / 商机 |
 |---|---|---|
 | CelVivo (ClinoStar) | **济南成全生物科技 (曹沛起)** — 华北 + 山东 跨区重复 | 董慧群 (CelVivo 技术同事) — 8-07 hook 4 候选 |
 | FemtoBiomed (CellShot / PROLIVA) | **9X Bio (汇佰生物)** — 中间方 (0 hit in 259 dealer 表) | TriArm Therapeutics (翁靖傑 上海 CGT/CAR-T, 128 万 Phase1 / 8-10 至 8-14 现场 demo) |
 | 3Brain (HD-MEA) | 0 家代理命中 | 11+ end-customer dossiers (需要补 direct agent or sell direct) |
 | Cellink (BIO X) | 0 家代理命中 | (待补) |
 **Data gap (regional filling rate):** 华东 营收 0/68 / 湖北 营收 0/19 / 华南 销售人数 0/62 — needs补 before next field visit. Documented at [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) §关键数据缺口.
-**4-vendor break-out is partially resolved:** the 2026-08-07 `_known_associations.md` index identifies CelVivo → 济南成全 + FemtoBiomed → 9X Bio; 3Brain / Cellink direct agents are still 0 (open-question `distributors-3brain-cellink-zero-coverage`).
+**4-vendor break-out is deferred:** brand counts by region for CelVivo / 3Brain / Cellink / Femtobiomed are "待详细匹配" — the cross-match between dealer + vendor product line is not yet in the source page.
 ## CRM — active distributor profiles
-From [`/sources/agents.md`](/sources/agents.md) (last sync 2026-07-28; 2026-08-07 `_known_associations.md` partial resolution):
+From [`/sources/agents.md`](/sources/agents.md) (last sync 2026-07-28):
 | 姓名 | 角色 | 代理商品牌 | 主推产品 | 首次记录 | 状态 | Vault 路径 |
 | --- | --- | --- | --- | --- | --- | --- |
@@ -299,9 +261,7 @@ From [`/sources/agents.md`](/sources/agents.md) (last sync 2026-07-28; 2026-08-0
 This is the only profile currently in the agents bucket. Robin was told about 董慧群 via WeChat DM on 2026-07-28; her role is to help push CelVivo products at the technical / demo / selection stage. Most fields are 待补 (agency name, region, phone, WeChat, customers, opportunities) — this is the only active open question in `/open-questions.md` (see `agent-dong-huiqun-celvivo`).
-**2026-08-07 partial resolution (Hermes hook 4):** 4 个经销商管理 Hook 升级 (`02-Clients/Agents/_known_associations.md` commit `4b237a82`) identifies **济南成全生物科技有限公司 (曹沛起)** as the only CelVivo ClinoStar-listed agent in the 259-dealer China map (华北 + 山东 跨区重复登记). Whether 董慧群 is 济南成全的技术同事 or another dealer is still unverified — tracked as commitment `dong-huiqun-ji-nan-chengquan-link` in `/commitments.md`. The same hook 4 file maps FemtoBiomed CellShot → 9X Bio (汇佰生物) → TriArm Therapeutics (翁靖傑 上海 CGT/CAR-T, 128 万 Phase1 / 8-10 至 8-14 现场 demo), and 3Brain / Cellink / FemtoBiomed direct agents → 0 in the 259 baseline (open-question `distributors-3brain-cellink-zero-coverage`).
+**Privacy rule (Robin 7-28):** `/sources/agents.md` and `/sources/distributors-china-2026.md` contain only base identity (name / role / vendor / region); sensitive fields (phone / WeChat / email / end-customer list / opportunity value) live only in the private Obsidian vault.
 **Privacy rule (Robin 7-28):** `/sources/agents.md` and `/sources/distributors-china-2026.md` contain only base identity (name / role / vendor / region); sensitive fields (phone / WeChat / email / end-customer list / opportunity value) live only in the private Obsidian vault. The 2026-08-07 `_known_associations.md` index adds the **product-line → agent → end-customer → opportunity** mapping chain — but does not break the privacy rule because sensitive fields remain in the private vault files.
 ## End-customer dossier set
@@ -317,8 +277,6 @@ A dedicated subfolder under `05-Documents/Products/Celvivo/Industrial-Customers/
 This is a self-contained CelVivo China commercial effort. The latest mtime census (2026-07-16 snapshot) shows `CelVivo_中国工业客户开发研究报告_20260626_v2.md` as the most-recent file (18 KB, 06-26 11:52). Documented at [`/sources/git-repo.md`](/sources/git-repo.md) §Notable entities.
 **2026-08-17 working-tree addition — `celvivo_commercial/1331651_20260630_131201.pdf`** (56 KB, 2026-06-30 quote PDF migrated into a new folder; **untracked**) — companion to the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree. The new folder name signals Robin may be consolidating "Celvivo commercial" documents into a separate vault subtree rather than continuing to nest them under `05-Documents/Products/Celvivo/Industrial-Customers/` (which is the prior convention). If the convention holds, future CelVivo commercial PDFs / quotes / pricing tables will land in `celvivo_commercial/` instead of `05-Documents/Products/Celvivo/Industrial-Customers/`; if it doesn't hold, it's a one-off folder for the 6-30 quote. Watchlist trigger: if a second PDF or commercial doc lands in `celvivo_commercial/` by the next git-repo fetch, the convention change is real; if it stays single-entry, it's a one-off.
 ## Work-rhythm snapshot (2026-07-16)
 From [`/sources/vault-mtime-snapshot-2026-07-16.md`](/sources/vault-mtime-snapshot-2026-07-16.md) (last full mtime census):
@@ -371,25 +329,6 @@ These are source-anchored but not vendor-anchored — they live here for traceab
 - **Work-rhythm snapshot connector** — currently a one-shot `find -mtime` shell command (see `/sources/vault-mtime-snapshot-2026-07-16.md` header). Promote to a weekly cron + auto-write to `/sources/vault-mtime-snapshot-weekly.md` so the work-rhythm signal is durable, not single-snapshot.
 - **End-customer dossier cross-agent page** — 11+ dossiers live in private vault; consider adding a redacted `[name, focus, vendor, region, vault-path]` table to `/sources/agents.md` parallel to the distributor profile pattern. Robin decision pending.
 - **CellShot-TriArm demo plan v3** — current demo plans are v1 (2026-07-21) and v2 (2026-07-22, 邮件用 + 老师版 two-commit split). No v3 yet; the v2 plan lives in vault commit history `1787702c` / `62877d1f` / `62d09c5f`. Promote to `/commitments.md` when v3 lands.
 - **MOC pattern extension (2026-08-10 onward)** — Robin created the first MOC
  (`04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md`, commit `6b717aef`,
  95 lines, 沙牛《AI 时代的 Obsidian 公开课》课时 1 pattern); the MOC's
  `related:` list already names the next planned MOC —
  `[[MOC-3Brain-HD-MEA]]` — plus
  `[[02-Clients/Agents/_known_associations]]` and
  `[[02-Active-Deals/CellShot-TriArm-Demo-计划-v2-老师版-2026-07-20]]`.
  Track on the next git-repo fetch whether the MOC pattern extends to
  MOC-3Brain-HD-MEA, MOC-Cellink-BIO-X, MOC-Femtobiomed-CellShot, etc.
  If ≥3 MOCs land, consider adding a `/themes.md` annex row on
  `vault-knowledge-architecture` and a `/sources/` page that maps the
  MOC graph (file → topics → cross-refs → flywheel cron hooks).
 - **Phase A frontmatter batch rollout (2026-08-10 onward)** — Phase A
  standardized 6 deep-read notes with the 6-field frontmatter
  (doi / journal / year / volume / pages / authors / pmid); ~1,196
  deep-read notes remain without the new fields. Track rollout
  cadence — if Robin completes the batch on a fixed cadence (e.g.
  daily/weekly cron), document the cadence here so future agents can
  answer "what is the frontmatter hygiene status of the vault?".
 ## What to read next
@@ -410,8 +349,4 @@ These are source-anchored but not vendor-anchored — they live here for traceab
 | How does the agent stack consume this output? | [`/themes/03-ai-agents.md`](/themes/03-ai-agents.md) |
 | How does the local-LLM fleet host this evidence? | [`/themes/04-local-llm.md`](/themes/04-local-llm.md) |
 | Where does CelVivo + 3Brain output land? | [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) |
-| Where does Cellink output land? | [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md) |
+| Where does Cellink output land? | [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md) |
 | What does Quintard 2024 say about vascularized organoid chips? | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
 | What does Guo 2026 say about organoid IRB ethics? | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
 | What's the IRB application checklist for organoid research? | `templates/类器官IRB申请清单.md` v1.0 (vault path; untracked) ||th; deep-read synthesis not yet split out to `/sources/`) |
 | What's the IRB application checklist for organoid research? | `templates/类器官IRB申请清单.md` v1.0 (vault path; untracked) ||