chore: daily update 2026-08-23

chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-23)
chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-22)
2026-08-23 02:33:39 +08:00 · 2026-08-23 02:30:02 +08:00 · 2026-08-22 02:30:02 +08:00 · 2026-08-22 02:17:39 +08:00 · 2026-08-21 02:30:02 +08:00 · 2026-08-21 02:27:31 +08:00
43 changed files with 5226 additions and 353 deletions
@@ -1,5 +1,7 @@
 {
-  "updatedAt": "2026-07-27T18:10:46.353Z",
+  "updatedAt": "2026-08-22T18:33:39.133Z",
  "command": "update",
-  "model": "MiniMax-M3"
+  "model": "MiniMax-M3",
  "status": "complete",
  "language": "en"
 }
@@ -1,3 +1,10 @@
 ---
 type: "Reference"
 title: "OpenWiki 现状 + 操作手册 (2026-07-27)"
 description: "Activation status + operations manual for Robin's local OpenWiki knowledge base as of 2026-07-27. Documents 4 active connectors (HN + git-repo + Tavily + RAGFlow) and the per-source sync scripts (HN top+best feeds, Tavily web-search with TAVILY_API_KEY, git-repo Obsidian vault at /home/ldw/workspace, RAGFlow full-text retrieval at 10.10.10.254:9980). Captures the on-disk Gitea commit + push pattern."
 tags: [openwiki, operations, manual, activation, 2026-07-27]
 ---
 # OpenWiki 现状 + 操作手册 (2026-07-27)
 > **这个 wiki 现在按预期运转中。** 4 个 connector 全部激活；2 个 connector (HN + web-search) 已经在 2026-07-27 早上拉过数据并 commit + push 到 Gitea。
@@ -1,3 +1,10 @@
 ---
 type: "Reference"
 title: "Commitments"
 description: "Active work tasks, follow-ups, approvals, and scheduled items extracted from sources (web-search, git-repo, literature flywheel-sync, etc.). Personal errands live in /personal-logistics.md instead."
 tags: [commitments, work, follow-ups, distributors-2026-08-07-refresh, dong-huiqun-ji-nan-chengquan-link, liang-2026-celvivo-clinostar-positioning, guo-2026-organoid-irb-checklist-rollout]
 ---
 # Commitments
 Concrete work tasks, follow-ups, approvals, and scheduled items extracted from Gmail, Notion, Slack, direct mentions, and other work-relevant sources. Personal errands and life admin live in `/personal-logistics.md` instead.
@@ -18,6 +25,104 @@ Concrete work tasks, follow-ups, approvals, and scheduled items extracted from G
 - Status: open
 - Notes: First vendor-anchored CelVivo ClinoReactor signal in any Tavily pull (prior pulls returned only MO:BOT / generic organoid). TheWell Bioscience is a hydrogel-media partner; their workflow pages position ClinoReactor as the scale-up vessel for apical-out organoids + hMSC expansion. Confirm with CelVivo whether this is a sanctioned co-marketing arrangement and whether it maps to any active Chinese pharma / CDMO deal.
 ### china-order-no-818-clinical-translation: verify Order No. 818 (effective 2026-05-01) scope for Chinese pharma / CDMO conversations
 - Owner: me
 - Source: web-search — BetaLife LinkedIn 2026-07 (top score 0.779; explicitly cites "Order No. 818, effective May 1, 2026" with accelerated clinical-translation pathway); Tavily answer text corroborates; Roots Analysis re-mentions broader China cell-therapy regulatory pattern
 - Due: unscheduled
 - Status: open
 - Notes: Single primary source (BetaLife SG LinkedIn) but the regulation itself is a published policy text — Order No. 818 creates an accelerated clinical-translation pathway at qualified hospitals for cell therapy and 3D bioprinting after demonstrating safety and preliminary efficacy. This is **the clinical-translation counterpart** to the existing `china-cde-cell-gene-therapy-rules-2026` item (which is about classification / CMC planning). Both items matter: classification scope drives dossier content vendors need to assemble; the clinical-translation pathway drives which hospitals can host first-in-human studies. Pull the NMPA / State Council Order No. 818 direct text before the next vendor sync; check whether any active CellShot-TriArm or ClinoReactor-class deal depends on whether the buyer hospital qualifies as a "qualified hospital" under the regulation.
 ### cellink-bio-x-gen3-customer-evidence: verify Cellink BIO X Gen 3 / BIO X6 customer pipeline on next Cellink check
 - Owner: me
 - Source: web-search — Nuclear Mechano-Oncology LinkedIn 2026-07 (score 0.601; "our new BIO X Gen 3 bioprinter has now been installed … first hands-on training session"); CELLINK official LinkedIn 2026-07-28 (score 0.287; BIO X6 at University of Miami 3D Bioprinting Facility); third-party market report LinkedIn 2026-07-28 (score 0.659; Cellink revenue uptick following strategic acquisitions); appellaser.ro practical selection guide 2026-07-24 (score 0.303; BIO X Gen 3 general-purpose positioning)
 - Due: unscheduled
 - Status: open
 - Notes: First vendor-anchored Cellink signal in any Tavily pull after 5 prior pulls of zero Cellink product mentions. Four distinct sources: customer install LinkedIn (Eastern Europe), vendor LinkedIn (CELLINK U. Miami), market report, independent selection guide. Verify with Cellink whether the BIO X Gen 3 / BIO X6 nomenclature is current product naming or if one is being deprecated; whether any of the named customer accounts (Nuclear Mechano-Oncology; U. Miami 3D Bioprinting Facility) maps to active Chinese pharma R&D / CDMO opportunities. Companion to the existing `celvivo-clinoreactor-thewell-bioscience-xeno-free` item.
 ### china-cgt-2026-july-developments: monitor gene-editing trial death fallout + Merck–Bio-Techne / CARsgen satri-cel context for Chinese pharma / CDMO positioning
 - Owner: me
 - Source: web-search — Straits Times 2026-07-24 (score 0.313; patient death in China gene-editing trial draws fire); LiveScience 2026-07-24 (score 0.145; 6-year-old girl, investigation into gene-therapy regulations); SCMP 2026-07-29 (score 0.203; "Fear of policy backlash" — same-day coverage with this Tavily pull); Roots Analysis 2026-07-24 (score 0.669; Merck–Bio-Techne $11.3B acquisition June 2026 + CARsgen satri-cel CAR-T approval for stomach cancer June 2026); BioSpace 2026-07-27 (score 0.535; Summit/Merck China-first regulatory navigation)
 - Due: unscheduled
 - Status: open
 - Notes: Material new development in the China regulatory lane — sits **on top of** the existing `china-cde-cell-gene-therapy-rules-2026` and `china-order-no-818-clinical-translation` items, not replacing them. Two positive signals (Merck–Bio-Techne acquisition; CARsgen satri-cel solid-tumor CAR-T approval) show the China CGT manufacturing environment is consolidating around advanced therapeutics. One negative signal (gene-editing trial death + published regulatory backlash) could foreshadow stricter CDE / NMPA / hospital-level oversight and tighter qualification criteria for "qualified hospitals" under Order No. 818. Together these affect: (a) qualification timelines for the CellShot-TriArm and ClinoReactor-class deals Robin has in flight, (b) which "qualified hospitals" remain eligible to host first-in-human studies, (c) whether CelVivo / 3Brain / Cellink vendor positioning for Chinese pharma R&D / CDMO accounts needs to change tone (e.g. emphasize safety documentation, IRB-grade workflows). Pull NMPA / hospital-IRB statements on the gene-editing trial case before next Chinese customer conversation.
 ### 3brain-coreplate-2026-conference-positioning: verify current CorePlate campaign and retrieve application material on next 3Brain check
 - Owner: me
 - Source: web-search — 3Brain official website plus 3Brain organization material captured through LinkedIn in Tavily pull 7 (2026-07-30); the dated result is 2026-07-25 and names ISSCR 2026 booth 412, while the company page also names ELRIG Drug Discovery booth 4. Tavily pull 11 (2026-08-03) adds a 3Brain LinkedIn post dated 2026-07-29 ("3Brain contributes to Utrecht Summer School course on Human Brain Models", score 0.808) — the **first Tavily pull where the 3Brain answer text is not mis-attribution** — and the 3Brain AG company LinkedIn page (score 0.839)
 - Due: unscheduled
 - Status: open
 - Notes: First credible direct 3Brain evidence after five Tavily pulls dominated by an unrelated EEG-paper mis-attribution. Vendor material positions CorePlate-enabled HD-MEA for high-resolution, scalable functional readouts from iPSC neuronal/cardiac models, brain organoids, assembloids, and 3D spheroids. Pull 11 extends the vendor-channel strand to the academic / training segment (Utrecht Summer School "Human Brain Models" course) on top of the ISSCR / ELRIG conference-booth strand from pull 7. Confirm which conference posts are current, obtain the named posters / application notes / Utrecht course module, and map them to Chinese neural-organoid and pharma-screening prospects. This pull does not establish CorePlate 1W/6W load force or Sample Holder Set details.
 ### celvivo-clinostar-2-nams-demo-2026: verify product naming and campaign provenance on next CelVivo check
 - Owner: me
 - Source: web-search — Instagram snippets surfaced in Tavily pull 7 (2026-07-30): ClinoStar webinar copy (`DbaUZjIjMgK`), NexUs Locus on-site demo copy dated 2026-07-24 (`DbKYC4NBtrN`), and ClinoStar 2 NAMs positioning (`DbSl7nkoFjK`). Tavily pull 11 (2026-08-03) adds an **independent confirmation** from an Indian distributor event page (labindia-analytical.com News & Events, score 0.696) that CelVivo is exhibiting at Thailand Lab 2026 (Bangkok, 2026-09-02 → 2026-09-04) and that `ClinoStar 2` is current product naming with oxygen regulation as a distinguishing feature
 - Due: unscheduled
 - Status: open
 - Notes: Watchlist lead, not a confirmed launch or customer win. Verify that the posts come from CelVivo or an authorized distributor, whether `ClinoStar 2` is current official product naming, and whether the NexUs Locus live demo produced reusable data or contacts. Pull 11's labindia-analytical.com result is the **first non-Instagram, named-event confirmation** of ClinoStar 2 + Thailand Lab 2026; treat it as independent corroboration, not vendor-direct. The result set does not support Tavily's “installed base” language; one malformed duplicate URL was discarded.
 ### cellink-volumetric-lumen-x-release: verify CELLINK × Volumetric new Lumen X release on next Cellink check
 - Owner: me
 - Source: web-search — Tavily pull 11 (2026-08-03) top hit on `Cellink BIO X bioprinter 2026`: 3DPrint.com 2026-07-28 (score 0.819) "CELLINK and Volumetric Release New Lumen X for Lumen X Bioprinting". Tavily answer text corroborates and adds BioMET '26 Vellore India (2026-08-05 → 2026-08-07) showcase detail. Companion evidence: Cellink LinkedIn 2026-07-29 (score 0.762) BioMET '26 exhibiting post; CELLINK Facebook 2026-07-28 (score 0.632) second-conference post
 - Due: unscheduled
 - Status: open
 - Notes: **First credible direct Cellink product / partnership release evidence on the Robin portfolio** after 10 prior Tavily pulls dominated by mis-attribution or BIO X Gen 3 / BIO X6 customer evidence (see existing `cellink-bio-x-gen3-customer-evidence`). Lumen X is in Robin's portfolio table ("Cellink — BIO X / BIONOVA X / Lumen X"). Verify with Cellink: (a) what is the relationship between CELLINK and Volumetric — co-marketing, OEM, distribution, or full acquisition; (b) is "New Lumen X" a distinct SKU from the original Lumen X (volumetric DLP) or a refresh; (c) does BioMET '26 Vellore presence map to any active Chinese pharma R&D / CDMO / biotech opportunities (likely India-channel rather than China-channel — adjacent to Robin's region); (d) does the existing `cellink-bio-x-gen3-customer-evidence` commitment's BIO X6 at U. Miami installation narrative change in light of this release.
 ### itx-24h-host-build-2026-q3: finish assembly + Ubuntu + Hermes install on Robin's 24h host (paused since hardware is 10/11 arrived)
 - Owner: me
 - Source: git-repo — `03-Resources/ITX-24h-Host/ITX_24h_Host_v18_Config_2026-07-31.md` (Obsidian vault, untracked as of fetch 2026-07-31T18:08:12Z)
 - Due: unscheduled (waiting for the last #8 / #9 cable parts on hand; once on hand, finish the assembly + software stack)
 - Status: open
 - Notes: Personal-infra work item (workflow-tooling priority LOW), not vendor-anchored — logged here because it is source-anchored to Robin's actual vault work per the brief's commitments.md rule ("only real Robin commitments"). Plan: mATX + i5-12400 + DDR4-2666 32G + 板载 Realtek 1Gb + Intel PRO/1000 GT (¥2,985.82, 10/11 parts on hand). Two 网卡 VLAN: 192.168.31.100 → 主力机 Win 11 SSH, 10.10.10.254 → 主力 NAS RAGFlow. Post-assembly steps: Ubuntu Server 22.04 LTS install, partition `/` (GM7 512G) + `/data` (mSATA 512G), Docker, dual-NIC 静态 IP, 主力机 SSH key 免密, NAS RAGFlow API 接入, 安装 Hermes Agent, 24h 跑功耗 soak test. The host has no vendor-product overlap; not promoted to `/themes.md` row because that index is reserved for recurring workflow signals.
 ### liu-2026-hd-mea-roadmap-implication: verify with 3Brain whether the Liu 2026 shape-conformal framework is on their product roadmap
 - Owner: me
 - Source: literature flywheel-sync 2026-08-08 — Liu N et al. (2026) Nature Biomedical Engineering, DOI 10.1038/s41551-026-01620-y, Wiki.js Id 1692, NocoDB row 1 in **new table `Robin_Picked_Papers`** (created 2026-08-08, table_id `mbjo0wb56qv1qly`), SeaFile PDF https://fb.biokingdom.top/f/6da50240729e41bdb369/?dl=1. Deep-read synthesis at [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md)
 - Due: unscheduled
 - Status: open
 - Notes: **Highest product-relevance cluster of today's flywheel-sync**: HD-MEA rating 5 (3000-8000 channels vs current 3Brain Accura-3D 4096; >90% surface coverage vs 5-15% bottom-only), 3D bioprinting microlattice rating 5 (Cellink BIONOVA X / Lumen X cannot directly print at this resolution today but the field direction is clear), patient-derived organoid drug screening rating 5 (first long-term high-throughput electrophysiology drug screening platform — weeks-long stable recording + epilepsy + AD disease modeling). Robin should sell 3Brain's current 4096-electrode Accura-3D as the existing best-in-class AND track whether 3Brain has a flexible-electronics / shape-conformal framework on their roadmap. Companion question on `/open-questions.md`: `liu-2026-rogers-lab-vs-3brain-relationship` (is there any partnership / licensing / competitive pressure between Rogers Lab and 3Brain?). Companion commitment to verify with Cellink: `liu-2026-cellink-microlattice-positioning` (whether BIONOVA X or Lumen X can fabricate flexible-electronics-compatible microlattices).
 ### miao-2025-celvivo-clinostar-positioning: fold Miao 2025 vHLPO co-differentiation story into CelVivo ClinoStar sales narrative
 - Owner: me
 - Source: literature flywheel-sync 2026-08-08 — Miao Y et al. (2025) Cell v2, DOI 10.1016/j.cell.2025.05.041, PMID 40592324, Wiki.js Id 1681, NocoDB row 93, SeaFile PDF https://fb.biokingdom.top/f/24704d54a95941449e2e/?dl=1. Deep-read synthesis at [`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`](/sources/literature-miao-2025-cell-vascularization-v2-deepread.md)
 - Due: unscheduled
 - Status: open
 - Notes: **Strongest CelVivo ClinoStar product relevance rating (5) in any of the 3 new flywheel-sync papers** — the vHLPO single 3D EB co-induction (mesoderm+endoderm) protocol depends on 3D EB self-organization in low-shear rotating culture, which is exactly what ClinoStar provides. vHLPO 7% ECs vs traditional HLPO 0% is a clinically-meaningful differentiator that no competing 2D / static culture can match. Sales ammunition: "your lung organoid model is missing 100% of vasculature — ClinoStar co-differentiation gives you 7% ECs vs 0%". Cross-vendor co-marketing: CelVivo ClinoStar (culture) + Cellink BIO X (decellularized lung scaffold) + 3Brain HD-MEA (functional readout on the neural mesenchyme). Robin should fold this into the CelVivo industrial-customers program (existing `CelVivo_中国工业客户开发研究报告` v1 + v2 in vault) and pitch to pediatric-hospital pharma R&D accounts (FOXF1 ACDMPV rare disease).
 ### liang-2026-celvivo-clinostar-positioning: fold Liang 2026 长程成熟 + 体外纤维化模型 story into CelVivo ClinoStar / ClinoReactor sales narrative
 - Owner: me
 - Source: git-repo-1 2026-08-12 (vault commit cluster `e542c977` → `8699a154` → `aacba7aa` → `297f106d`) — Liang Y, Ye Y, Xie H, Lui VCH, Chen Y, Tam PKH. (2026) *Scientific Reports* DOI 10.1038/s41598-026-42990-2, PMID 41857098; Wiki.js Id 1716, NocoDB Id 770; SeaFile PDF https://fb.biokingdom.top/f/9d53cfaaa88a45b49b72/?dl=1 + 7 真图 (Fig1-7); vault path `04-Literature/Deep-Reads/Liver/2026-08-12_Liang_2026_SciRep_liver_organoid_fibrosis_platform.md` (170 lines; 4-commit LDR cycle)
 - Due: unscheduled
 - Status: open
 - Notes: **Parallel CelVivo ClinoStar rating 4 + ClinoReactor rating 4 to the existing `miao-2025-celvivo-clinostar-positioning`** but for **liver organoid (long-term maturation + fibrosis modeling)** rather than lung organoid (vascularization). Single tissue 3-轨道 (Hep-Orgs + Cho-Orgs + HSC) → DAPT (Notch 抑制) + Dexamethasone for **P1-P10 长程稳定成熟** (single DAPT only sustains P5; DAPT+Dex 协同才实现 P10) → TGFβ 5-7 day activation of qHSC → aHSC (Acta2/Col1a1 上调) → aHSC 共培养诱导 Hep-Orgs **EMT (Snail/Twist/Vimentin ↑; ALB/CK8 ↓; Lgr5/EpCAM ↓; Ki67 ↓)** = **体外肝纤维化模型**. Sales ammunition: "你的肝类器官只能短期培养? DAPT+Dex P1-P10 稳定成熟 + 单组织 3 轨道 + 14 天纤维化模型 — ClinoStar + ClinoReactor 一站搞定"; paired with "你的抗纤维化药筛需要 14+ 天 3D 多细胞模型 — ClinoReactor 6 通道一次测 6 药". Cross-vendor co-marketing: **CelVivo ClinoStar (P1-P10 旋转扩增) + CelVivo ClinoReactor (3 轨道分通道灌流 + TGFβ 时间程序精确切换) + 3Brain HD-MEA (肝-神经互作延伸, 胆碱能投射场景)**. Customer entry: (a) 药企临床前 — 抗纤维化药筛 14+ 天 3D 多细胞模型 (traditional 2D 或单细胞模型失真); (b) 临床肝活检中心 — 1-2 mg 组织 → 3 轨道 → 3 周内药敏测试 (患者来源 anti-fibrosis drug sensitivity); (c) 学术 PI — 2D 静态分化效率低 → 3D 旋转培养效率提升 2-3 倍. Robin should fold this into the CelVivo industrial-customers program (existing `CelVivo_中国工业客户开发研究报告` v1 + v2 in vault) alongside the Miao 2025 vHLPO entry — these two papers together give a liver + lung CelVivo ClinoStar sales narrative with no 3D-bioprinting vendor dependency. The paper's `related:` field already names `[[MOC-类器官与3D培养]]` (the 2026-08-10 first MOC) — confirms the MOC pattern is in active use on real deep-reads on the day of publication.
 ### robin-picked-papers-nocodb-table: capture the structural change — new NocoDB table for Robin-handpicked papers
 - Owner: me
 - Source: literature flywheel-sync 2026-08-08 — Liu 2026 is the **first entry** in the new NocoDB table `Robin_Picked_Papers` (table_id `mbjo0wb56qv1qly`), created 2026-08-08 per Robin instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage. The table is separate from the existing `Organoid_Literature` table.
 - Due: unscheduled
 - Status: open
 - Notes: The new table has 9 fields: Title, DOI, Journal, Year, Authors, Source, wiki_url, pdf_url, deep_read_summary. Future handpicked papers should land in this table rather than in `Organoid_Literature` (which is PubMed-triage-driven). Verify with Robin: (a) what is the workflow for capturing a handpicked paper — manual PDF drop to `/home/ldw/.hermes/cache/documents/` and then trigger the LDR pipeline; (b) should the LDR pipeline auto-route by signal (PubMed triage vs handpicked), or does Robin always provide the routing signal.
 ### dong-huiqun-ji-nan-chengquan-link: confirm whether 董慧群 is a 济南成全生物科技 技术同事, and route 卸慧群档案 accordingly
 - Owner: me
 - Source: git-repo 2026-08-08 — `02-Clients/Agents/_known_associations.md` (commit `4b237a82`, Hermes Agent 2026-08-07 hook 4) maps 济南成全生物科技有限公司 (曹沛起) as the **only CelVivo ClinoStar-listed agent** in the 259-dealer China map (华北 + 山东 跨区重复登记). `02-Clients/Agents/董慧群.md` (2026-07-28 commit `21491578`) lists 董慧群 as CelVivo 产品技术同事 with `agency: 待补`.
 - Due: unscheduled
 - Status: open
 - Notes: The 2026-08-07 hook 4 partial-resolution gave a likely candidate (济南成全生物科技 曹沛起 company) but the precise link to 董慧群 (and whether she is 济南成全的技术同事, or another dealer) is still unverified. Action: Robin to verify with 董慧群 directly via WeChat / 微信 (current open-question [`/open-questions.md`](/open-questions.md) `agent-dong-huiqun-celvivo`). Once confirmed: update `02-Clients/Agents/董慧群.md` frontmatter `agency` field, and update [`/sources/agents.md`](/sources/agents.md) "代理商品牌" column from "待补" to "济南成全生物科技 (曹沛起)". Until this is done, 董慧群's role in the 济南成全 book of business is unconfirmed.
 ### distributors-2026-08-07-refresh: 落地 2026-08-07 全国经销商地图到 wiki + 跨工具
 - Owner: me
 - Source: git-repo 2026-08-08 — Obsidian vault `02-Clients/Agents/全国经销商地图-2026-0807.md` + 7 区域分文件 (8-07 baseline, 259 dealers across 7 regions, net change -2 from 2026-07-24 baseline). Vault raw survives 2026-08-08 fetch as untracked files (commit `4b237a82` Lin Yongli "4 个经销商管理 Hook 升级").
 - Due: unscheduled
 - Status: open
 - Notes: 8-07 baseline differs from 7-24 baseline in: (a) total 261 → 259 (华北 74 → 72); (b) 济南成全生物科技有限公司 (曹沛起) cross-region registration (华北 + 山东); (c) new `_known_associations.md` index maps CelVivo → 济南成全 / FemtoBiomed → 9X Bio → TriArm / 3Brain + Cellink → 0. Cross-reference: [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) has been updated to the 8-07 baseline + new associations table; [`/sources/agents.md`](/sources/agents.md) still needs the 董慧群 → 济南成全 link; [`/commitments.md`](/commitments.md) has follow-up for 成都百乐 vs 成都立德赛 decision (open-question `chengdu-baile-vs-lidesai-for-ou-xianhong`). End-customer coverage for 3Brain / Cellink / FemtoBiomed still 0 in the 259 baseline — see open-question `distributors-3brain-cellink-zero-coverage`.
 ### guo-2026-organoid-irb-checklist-rollout: commit IRB application checklist template + add Guo 2026 deep-read synthesis page + fold into CelVivo industrial-customers program
 - Owner: me
 - Source: git-repo-1 2026-08-17 — vault commit cluster `2e6f5989` → `00f824f2` → `a4fa5a32` (Guo Z & Zhang N 2026 Front Cell Dev Biol organoid IRB / ethics systematic review, Wiki.js ID 1724, NocoDB Id 3298, DOI 10.3389/fcell.2026.1721946) + new untracked `templates/类器官IRB申请清单.md` v1.0 (180 lines, Robin 8-16 实战沉淀, derived from the Guo 2026 paper)
 - Due: unscheduled
 - Status: open
 - Notes: **First customer-facing template produced from a single deep-read** in Robin's vault — the IRB application checklist is the canonical "Robin 培训客户 IRB 申请" core material for class A tertiary hospitals running organoid IRB submissions. The 7 mandatory points + 5 customer Q&A + China vs International flow table + 10 attachments + 7 citations map directly to the CelVivo ClinoStar clinical-translation sales narrative (Guo 2026 lists CelVivo ClinoStar ⭐⭐⭐⭐ for IRB compliance ammunition). **Three follow-ups needed**: (a) **commit** `templates/类器官IRB申请清单.md` to `main` (currently untracked); (b) add a wiki-side deep-read synthesis page at `/sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md` mirroring the pattern at `/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`; (c) fold the IRB checklist into the existing `05-Documents/Products/Celvivo/Industrial-Customers/` CelVivo commercial docs subtree (or, if the `templates/` folder convention holds, fold it into the new `templates/` vault subtree instead — see Robin decision). Companion commitment to fold into Chinese customer IRB conversations: the checklist covers China《人类遗传资源管理条例》+ 《涉及人的生命科学和医学研究伦理审查办法》2023 — directly applicable to the next Class A tertiary hospital Robin visits for CelVivo or 3Brain training.
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 # Files
 - [Commitments](commitments.md) - Active work tasks, follow-ups, approvals, and scheduled items extracted from sources (web-search, git-repo, literature flywheel-sync, etc.). Personal errands live in /personal-logistics.md instead.
 - [2026-07-16 工具链打通战报](memory-2026-07-16-tools-final.md) - After-action report on Robin's 2026-07-16 end-to-end toolchain integration: OpenWiki + Gitea + NocoDB + RAGFlow + Wiki.js + MiniMax code all wired together and working in production. Snapshot of the pre-flywheel-sync state — pre-dates the 2026-07-26 HN + Tavily launches and the 2026-07-29 Tavily cluster / 2026-08-08 literature flywheel-sync milestones.
 - [Open Questions](open-questions.md) - Active, Answered, and Stale unresolved questions about Robin's memory, recurring routines, people, projects, and wiki quality. Source-document TODOs and product questions live on their source pages instead.
 - [Personal Logistics](personal-logistics.md) - Personal errands, appointments, pickups, travel, household/life-admin deadlines, and other non-work logistics. Work commitments live in /commitments.md.
 - [Robin's Local Knowledge Base](quickstart.md) - OpenWiki entrypoint and orientation — Robin's personal knowledge base with 5 synthesis themes (organoid equipment, bioprinting, AI agents, local LLM, personal research), navigation map, current connector status, and backlog.
 - [OpenWiki 现状 + 操作手册 (2026-07-27)](README-ACTIVATION.md) - Activation status + operations manual for Robin's local OpenWiki knowledge base as of 2026-07-27. Documents 4 active connectors (HN + git-repo + Tavily + RAGFlow) and the per-source sync scripts (HN top+best feeds, Tavily web-search with TAVILY_API_KEY, git-repo Obsidian vault at /home/ldw/workspace, RAGFlow full-text retrieval at 10.10.10.254:9980). Captures the on-disk Gitea commit + push pattern.
 - [Themes](themes.md) - Recurring topics, signals, and trends observed across Robin's sources. Index of theme rows with confidence labels and source citations; details live on the linked source and synthesis pages.
 # Directories
 - [large_tool_results](large_tool_results/)
 - [sources](sources/)
 - [themes](themes/)
@@ -1,3 +1,10 @@
 ---
 type: "Reference"
 title: "2026-07-16 工具链打通战报"
 description: "After-action report on Robin's 2026-07-16 end-to-end toolchain integration: OpenWiki + Gitea + NocoDB + RAGFlow + Wiki.js + MiniMax code all wired together and working in production. Snapshot of the pre-flywheel-sync state — pre-dates the 2026-07-26 HN + Tavily launches and the 2026-07-29 Tavily cluster / 2026-08-08 literature flywheel-sync milestones."
 tags: [toolchain-integration, openwiki, gitea, nocodb, ragflow, wikijs, milimax-code, 2026-07-16]
 ---
 # 2026-07-16 工具链打通战报
 > 2026-07-16, Robin 完整跑通: OpenWiki + Gitea + NocoDB + RAGFlow + Wiki.js + MiniMax code.
@@ -1,10 +1,45 @@
 ---
 type: "Reference"
 title: "Open Questions"
 description: "Active, Answered, and Stale unresolved questions about Robin's memory, recurring routines, people, projects, and wiki quality. Source-document TODOs and product questions live on their source pages instead."
 tags: [open-questions, unresolved, agent-dong-huiqun-celvivo, chengdu-baile-vs-lidesai-for-ou-xianhong, distributors-3brain-cellink-zero-coverage]
 ---
 # Open Questions
 Unresolved questions about Robin's memory, recurring routines, people, projects, and wiki quality. Source-document TODOs and product questions live on their source pages instead.
 ## Active
-_No active open questions yet. New ones will be added here as evidence surfaces real gaps._
+### agent-dong-huiqun-celvivo: which distributor does 董慧群 belong to, and what region / customers / contact info does she cover?
 - Owner: me (Robin)
 - Seen: 2026-07-28
 - Evidence: `02-Clients/Agents/董慧群.md` in the Obsidian vault (frontmatter `type: agent`, role: 代理商技术同事, products: CelVivo ClinoStar / ClinoReactor, status: active, last-contact: 2026-07-28). Manifest entry: `~/.openwiki/connectors/git-repo/raw/2026-07-28T18-07-57-114Z/manifest.json` commit `21491578`. 2026-08-07 partial resolution: `02-Clients/Agents/_known_associations.md` (commit `4b237a82`, Hermes Agent hook 4) identifies **济南成全生物科技有限公司 (曹沛起)** as the only ClinoStar-listed agent in the 259-dealer China map — 华北 + 山东 跨区重复登记. Cross-reference at [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) § "8-07 新增：_known_associations.md 索引".
 - Notes: profile is mostly 待补 (agency company name, region, phone, WeChat, served end-customers, opportunities). Robin was told about 董慧群 via WeChat DM on 2026-07-28 — her role is to help push CelVivo products at the technical / demo / selection stage. The 2026-08-07 `123hook_4` partial-resolution gave a likely candidate (济南成全生物科技有限公司 — same contact 曹沛起 in both 华北表 + 山东表) but the precise link to 董慧群 (and whether she is 济南成全的技术同事, or another dealer) is still unverified. Until confirmed, future agents cannot reason about which CelVivo deals 董慧群 might support or which Chinese pharma R&D / CDMO accounts overlap with her territorial reach. The narrower, still-open question is: **is 董慧群 济南成全生物科技 (曹沛起) 的技术同事, or another CelVivo-aligned agent?**
 ### liu-2026-rogers-lab-vs-3brain-relationship: is there any partnership / licensing / competitive pressure between Rogers Lab (Liu 2026) and 3Brain?
 - Owner: me (Robin)
 - Seen: 2026-08-08
 - Evidence: literature flywheel-sync 2026-08-08 — Liu N et al. (2026) Nature Biomedical Engineering, DOI 10.1038/s41551-026-01620-y, Wiki.js Id 1692, SeaFile PDF https://fb.biokingdom.top/f/6da50240729e41bdb369/?dl=1. Deep-read at [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md). Commitment at [`/commitments.md`](/commitments.md) `liu-2026-hd-mea-roadmap-implication`.
 - Notes: Liu 2026 establishes a next-gen shape-conformal porous framework for full-coverage (>90% surface) neural organoid electrophysiology at 3000-8000 channels per organoid (10-50× current 3Brain Accura-3D). Rogers Lab (Northwestern) is a major flexible-electronics / bioelectronics group. Three plausible relationships with 3Brain: (a) **partnership** — Rogers Lab licenses the flexible-electronics framework to 3Brain for productization; (b) **competitive pressure** — Rogers Lab or a spinout company commercializes the framework as a competing HD-MEA product; (c) **academic-only** — Rogers Lab has no commercial intent and 3Brain continues to be the best-in-class commercial HD-MEA. Until this is clarified, Robin cannot advise 3Brain customers on whether to wait for next-gen HD-MEA hardware or buy current Accura-3D now. Future agents reading Liu 2026 should treat the "next-gen direction" framing with caution until the 3Brain roadmap is verified.
 ### chengdu-baile-vs-lidesai-for-ou-xianhong: which 成都 dealer should Robin approach first for 西南医科大学心研所 (殴贤红) CelVivo / 3Brain cross-sell?
 - Owner: me (Robin)
 - Seen: 2026-08-07
 - Evidence: `02-Clients/Agents/_known_associations.md` (Obsidian vault, 2026-08-07 commit `4b237a82`) — 候选代理 A: **成都百乐 (杨军)** — 覆盖川渝黔藏 · 1亿/钻石 · 主营 Bio-Rad/Sartorius/Oxford Nanopore/Cytek/Leica; 候选代理 B: **成都立德赛** — 覆盖川渝云贵陕. End-customer: 西南医科大学心血管研究所 (殴贤红, 四川泸州). Cue: Hermes hook 4 recommended "先联系 成都百乐 (钻石级 1亿, 主营匹配度更高)". Cross-reference: [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) § "8-07 新增：_known_associations.md 索引".
 - Notes: Robin needs to pick the first 成都 dealer to approach for the 殴贤红 CelVivo / 3Brain cross-sell. Two candidates identified in the 2026-08-07 `_known_associations.md` sweep: 成都百乐 (1亿/钻石级, 川渝黔藏 + 主营 Bio-Rad/Sartorius/Oxford Nanopore/Cytek/Leica — overlap with FemtoBiomed / 3Brain product line) vs 成都立德赛 (覆盖川渝云贵陕, 主营待查). Hermes hook 4 default recommendation is 成都百乐, but Robin's existing relationship depth with either dealer is unknown. Until Robin makes the call, the cross-sell cannot be initiated.
 ### distributors-3brain-cellink-zero-coverage: 259 dealer list shows 0 三Brain / 0 Cellink / 0 FemtoBiomed direct agents — is the channel gap real, or is the 8-04 xlsx missing these brands?
 - Owner: me (Robin)
 - Seen: 2026-08-07
 - Evidence: `02-Clients/Agents/_known_associations.md` (Obsidian vault, 2026-08-07 commit `4b237a82`) — product-line hit summary shows only CelVivo (济南成全) directly; 3Brain / Cellink / FemtoBiomed all 0. FemtoBiomed CellShot is documented as a 9X Bio (汇佰生物) direct intermediate, not in the 259 dealer list. Cross-reference: [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) § "8-07 新增：_known_associations.md 索引".
 - Notes: The 2026-08-07 xlsx-baseline scan found zero dealers in the 259-row list that explicitly carry 3Brain HD-MEA or Cellink BIO X. For 3Brain HD-MEA, where Robin has 11+ end-customer dossiers (神经所 / 北京大学 / 北京天坛 / 浙大一附院 / 中科院昆明 / 西南医大 / 贵州医大 / 云南中医药 / 天津创新中药), this is a striking gap — either (a) the 8-04 xlsx is missing the 3Brain agents, or (b) no Chinese distributor has picked up 3Brain and Robin needs to either find/appoint one or sell direct. Until Robin clarifies, the 3Brain-side commercial strategy (channel vs direct) for the +11 known Chinese end-customers remains unresolved.
 ### sharma-2026-retinal-organoid-mea-cross-sell: does the 60-channel MCS MEA route transfer cleanly to 3Brain HD-MEA for vascularized retinal organoid RGC recording?
 - Owner: me (Robin)
 - Seen: 2026-08-08
 - Evidence: literature flywheel-sync 2026-08-08 — Sharma K et al. (2026) Cell Stem Cell 33:253-271.e13, DOI 10.1016/j.stem.5.12.013, PMID 41529691, Wiki.js Id 1678, NocoDB row 700, SeaFile PDF https://fb.biokingdom.top/f/861202f029004d75b456/?dl=1. Deep-read at [`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`](/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md).
 - Notes: Sharma 2026 records vascularized retinal organoid (vRO) W31 ON/OFF/ON-OFF light responses using **60-channel MCS MEA2100-Lite** (not HD-MEA) — 60 channels at 32 kHz, no HD spatial resolution. The RGC fraction (W18: 18.2% vs 1.21% ctrl-RO) and the W31 light responses are clinically meaningful, but the MEA is bottom-surface-only (no 3D spatial resolution). Robin's own flywheel audit flagged product_relevance.rating=4 for 3Brain HD-MEA on the basis that "technical route is transferable" — but the actual technical transfer requires verifying that 3Brain's Accura-3D chip supports opsin + optogenetic + light-response recording at week-31+ retinal organoid maturity (long-duration stability). Without this confirmation, the cross-sell pitch to 3Brain's retinal-organoid accounts is theoretical. Future agents pitching Sharma 2026 to 3Brain prospects should verify the technical route end-to-end before committing.
 <!--
 Structure for new entries:
@@ -1,3 +1,10 @@
 ---
 type: "Reference"
 title: "Personal Logistics"
 description: "Personal errands, appointments, pickups, travel, household/life-admin deadlines, and other non-work logistics. Work commitments live in /commitments.md."
 tags: [personal-logistics, life-admin, travel]
 ---
 # Personal Logistics
 Personal errands, appointments, pickups, travel, household/life-admin deadlines, and other non-work logistics. Work commitments live in `/commitments.md`.
@@ -1,3 +1,10 @@
 ---
 type: "Reference"
 title: "4-27 SOP 实战 vs 实现差异 (2026-07-27 Tasevska 2025 重做教训)"
 description: "Lessons-learned capture from Robin's 2026-07-27 Tasevska 2025 EJPS deep-read redo — 9-step comparison table of 4-27 SOP范本 vs 7-27 凭印象实操 (Tasevska + Raji 2 篇) vs 4-27 SOP 走通 (Tasevska 重做); detailed PyMuPDF 嵌入图过滤 rules, Ollama 视觉 fallback chain, NocoDB v1 vs v2 protocol, and the 9-step mandatory format. Applies to every literature-deep-read invocation. Companion to `/sources/ldr-report-template.md`."
 tags: [literature-deep-read, sop-vs-implementation, lessons-learned, pymupdf, ollama, nocodb, 2026-08-13]
 ---
 # 4-27 SOP 实战 vs 实现差异 (2026-07-27 Tasevska 2025 重做教训)
 > Robin 2026-07-27 反馈 "之前是有文献精读质量sop的, 你为什么不参考那个" — 立刻做教训固化
@@ -1,3 +1,10 @@
 ---
 type: "Reference"
 title: "OpenWiki 速查手册 (Robin 一次聊清, 直接拿来用)"
 description: "Compact OpenWiki cheat-sheet that condenses the 2026-07-27 6-conversation walkthrough into a single ready-to-share document. Designed for one-shot delivery to any agent / colleague / customer / manager who asks 'what is OpenWiki?' — covers the core concept, structure, sync model, and 4 active connectors in one page."
 tags: [openwiki, cheat-sheet, reference, onboarding, 2026-07-27]
 ---
 # OpenWiki 速查手册 (Robin 一次聊清, 直接拿来用)
 > **目的**: 这份文档是 2026-07-27 一天 6 次对话的**完整沉淀**. 之后你跟任何 agent / 同事 / 客户 / 老板 提 OpenWiki, 直接把这份文档发过去, **不需要**重新讲一遍.
@@ -1,3 +1,11 @@
 ---
 type: "Reference"
 title: "Sources"
 description: "Per-connector evidence indexes and ingestion coverage for the local knowledge wiki; durable synthesis lives on canonical pages."
 tags: [sources, connectors, evidence, ingestion, 2026-08-22]
 timestamp: 2026-08-22T18:00:32Z
 ---
 # Sources
 Per-connector evidence indexes. Each connector gets its own page (for example `gmail.md`, `slack.md`) that records ingestion coverage, freshness, and a compact evidence trail. Durable synthesis lives on the canonical pages (`/themes.md`, `/commitments.md`, `/personal-logistics.md`, `/open-questions.md`); these source pages are the evidence layer underneath.
@@ -6,8 +14,9 @@ Per-connector evidence indexes. Each connector gets its own page (for example `g
 | Connector | Page | Status |
 | --- | --- | --- |
-| Hacker News (`hackernews-1`, LLM-agent topics) | [/sources/hackernews.md](/sources/hackernews.md) | active |
+| Hacker News (`hackernews-1`, LLM-agent topics) | [/sources/hackernews.md](/sources/hackernews.md) | active (last 2026-08-22 18:00 UTC — twelfth pull since 2026-08-07 with an empty / noise-only Algolia lane on vendor queries; the 2026-08-22 pull reverts to the noise-only shape (organoid 5 hits + CelVivo 0 + 3Brain 6 hits + Cellink 3 hits + openwiki 0 + deepagents 0) after the 2026-08-21 fully-zero pull — NOT a third fully-zero Algolia lane in a row; the noise-only Algolia substring hits include **1 thematic organoid duplicate** (`49400587` Nautilus "The Remarkable Lives of 5-Year-Old Brain Organoids" 1 pt top, the 3rd neural-organoid HN signal in 11 pulls after the 2026-07-27 Nature biocomputing `49071596` + 2026-08-12 Wired `49266068` + 2026-08-20 Nature `49366519` + Science Alert `49373812`) + **2 agent-memory-architecture adjacents** (`49394827` OzBrain 72 pts top, submitter text explicitly cites "Obsidian vaults with 7k files synced through a VPS, markdown repos behind their own MCP servers" — exact architectural parallel to Robin's OpenWiki + Obsidian vault stack; `49399942` Knowl 1 pt top, open-source MCP-backed agent memory with memory-pruning pattern — same pattern the `agent-memory-architecture` row anchors on); the strongest named-stack-adjacent items are `49398152` "Munder Difflin – Agent harness to run an office of your clones" 192 pts top (agent harness cross-walks to the same agent-as-primary-compute-substrate narrative Robin's `hermes-agent-v0-19-quicksilver` row documents; **5th entry in the now 5-day self-hosted-agentic-substrate cluster** — DeepSeek Harness 2026-08-13 + machine0 2026-08-18 + OneCLI 2026-08-19 + self-hosted agentic software factory 2026-08-21 + **Munder Difflin 2026-08-22** — 5 independent submissions across 5 consecutive working days, with Munder Difflin's 192-pt engagement being the second-highest of the cluster after the 422-pt DeepSeek Harness; cluster is now an emerging-pattern watchlist candidate) + `49399591` "New MCP Roadmap" 120 pts top (official MCP roadmap from the canonical MCP blog at blog.modelcontextprotocol.io — **first MCP-protocol roadmap entry since the 2026-07-28 MCP revision finalization** documented on the `hermes-agent-v0-19-quicksilver` row; **MCP substrate is its own substrate-cluster watchlist candidate** — MCP Memory 2026-08-13 + machine0 MCP support 2026-08-18 + OneCLI MCP connectors 2026-08-19 + **New MCP Roadmap 2026-08-22** — 4 distinct substrate-protocol signals across 4 pulls in 10 days; MCP is the protocol-layer substrate of every named-stack item on Robin's workflow — Hermes Agent / Codex CLI / OpenWiki / RAGFlow / machine0 / OneCLI all depend on MCP), with five additional adjacents flagged for traceability: `49394827` OzBrain 72 pts top (3Brain substring-noise duplicate; direct Obsidian-vault + MCP architectural parallel to Robin's OpenWiki stack; adjacent-not-promoted per scope), `49399942` Knowl 1 pt top (Cellink substring-noise duplicate; open-source MCP-backed agent memory with memory-pruning pattern; adjacent-not-promoted per scope), `49400587` Nautilus 5-Year-Old Brain Organoids 1 pt top (organoid/3Brain substring-noise duplicate; 3rd neural-organoid HN signal in 11 pulls; flagged-for-traceability rather than promoted because 1-pt engagement is below the 5-pt 2026-08-12 Wired + 18-pt 2026-08-20 Nature engagement thresholds that drove prior `class-organoid-3d-bioprinting` Last-seen refreshes), `49401549` Anthropic Claude Code A/B testing reduced effort levels 29 pts top (4th Claude Code traceability entry in 14 days; adjacent-not-promoted per scope — Claude Code is not on Robin's named stack), `49394496` "Three important steps in my maturation process" 199 pts best (Thomas Dullien personal-blog essay; adjacent-not-promoted per scope — off-scope per scope discipline), `49397947` "Embedded AI" 29 pts top (No Starch Press book publication; adjacent-not-promoted per scope — book publication, not a vendor stack change)) |
-| Git repo (`obsidian-robin`, Obsidian vault) | [/sources/git-repo.md](/sources/git-repo.md) | active |
+| Git repo (`git-repo-1`, Obsidian vault + OpenWiki wiki) | [/sources/git-repo.md](/sources/git-repo.md) | active (last 2026-08-22 18:13 UTC — 0 new vault commits since 2026-08-21T18:09Z fetch (vault silent for the 6th consecutive fetch, **6 calendar days stale** since the 2026-08-16 Quintard + Guo cluster); 2 new automated wiki commits since 2026-08-21T18:09Z fetch (`d8e2277` daily update 2026-08-22 + `43d4548` sources-sync 2026-08-22, the eighth consecutive sources-sync re-applying the 2026-08-15 count-data wipe pattern)) |
 | Web Search (`web-search-1`, Tavily) | [/sources/web-search.md](/sources/web-search.md) | active (latest pull 2026-08-03; 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, 2026-08-17, 2026-08-18, 2026-08-19, 2026-08-20, 2026-08-21, and 2026-08-22 update attempts skipped — connector not enabled, `TAVILY_API_KEY` missing) |
 Additional connectors appear here automatically once they are authenticated and ingested at least once.
@@ -19,9 +28,9 @@ Additional connectors appear here automatically once they are authenticated and
 | Slack | not configured | `openwiki auth slack` | Needs `search:read` for definitive self-message search; otherwise falls back to recent conversations. |
 | Notion | not configured | Notion MCP credentials | Discovery via `openwiki_list_mcp_tools`; do not guess tool names. |
 | X / Twitter | not configured | `OPENWIKI_X_ACCESS_TOKEN` via `openwiki auth x` | Streams: `home_timeline`, `user_posts`, `mentions`, `bookmarks`, `list_posts`. |
-| Web Search | not configured | `TAVILY_API_KEY` | Tavily via LangChain; reads configured queries. |
+| Web Search | **active** (`web-search-1`) | `TAVILY_API_KEY` (currently empty) | Tavily via LangChain; reads configured queries. Latest successful pull 2026-08-03 18:08 UTC; the 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, 2026-08-17, 2026-08-18, 2026-08-19, 2026-08-20, 2026-08-21, and 2026-08-22 update attempts were skipped because the connector was not enabled in the runtime registry (tenth consecutive skip on the same code path; nightly searxng-fallback slot for 2026-08-21 is also empty on disk). Evidence at [/sources/web-search.md](/sources/web-search.md). |
-| Hacker News | **active** (`hackernews-1`) | _(public, no auth)_ | Public feeds (`top`, `new`, `best`) + Algolia HN search queries. Evidence at [/sources/hackernews.md](/sources/hackernews.md). |
+| Hacker News | **active** (`hackernews-1`) | _(public, no auth)_ | Public feeds (`top`, `new`, `best`) + Algolia HN search queries. Source-specific query set: `organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents` (LLM-agent topics per the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories"). Last successful pull 2026-08-22 18:00 UTC — **twelfth pull since 2026-08-07 with an empty / noise-only Algolia lane on vendor queries** (after the 2026-08-08 03:15 + 2026-08-08 18:00 + 2026-08-15 + 2026-08-16 + 2026-08-18 + 2026-08-19 + 2026-08-21 fully-zero pulls + the 2026-08-10 + 2026-08-12 + 2026-08-17 + 2026-08-20 + 2026-08-22 noise-only pulls where vendor queries returned substring-fragment noise; the **2026-08-22 pull reverts to the noise-only shape after the 2026-08-21 fully-zero pull** — substring-noise on organoid/3Brain/Cellink (5+6+3=14 hits) + clean zero on CelVivo/openwiki/deepagents — and is **NOT** the third fully-zero Algolia lane in a row; empty-pulls-on-vendor-queries is normal cadence, not an outage). The two strongest named-stack-adjacent items of the pull are `49398152` "Munder Difflin – Agent harness to run an office of your clones" 192 pts top (agent harness cross-walks to the same agent-as-primary-compute-substrate narrative Robin's `hermes-agent-v0-19-quicksilver` row documents; **5th entry in the now 5-day self-hosted-agentic-substrate cluster** — DeepSeek Harness 2026-08-13 + machine0 2026-08-18 + OneCLI 2026-08-19 + self-hosted agentic software factory 2026-08-21 + **Munder Difflin 2026-08-22** — 5 independent submissions across 5 consecutive working days, with Munder Difflin's 192-pt engagement being the second-highest of the cluster after the 422-pt DeepSeek Harness; cluster is now an emerging-pattern watchlist candidate) + `49399591` "New MCP Roadmap" 120 pts top (official MCP roadmap from the canonical MCP blog at blog.modelcontextprotocol.io; **first MCP-protocol roadmap entry since the 2026-07-28 MCP revision finalization**; **MCP substrate is its own substrate-cluster watchlist candidate** — MCP Memory 2026-08-13 + machine0 MCP support 2026-08-18 + OneCLI MCP connectors 2026-08-19 + **New MCP Roadmap 2026-08-22** — 4 distinct substrate-protocol signals across 4 pulls in 10 days); five additional adjacents flagged for traceability: `49394827` OzBrain 72 pts top (3Brain substring-noise duplicate; direct Obsidian-vault + MCP architectural parallel to Robin's OpenWiki stack; adjacent-not-promoted per scope), `49399942` Knowl 1 pt top (Cellink substring-noise duplicate; open-source MCP-backed agent memory with memory-pruning pattern; adjacent-not-promoted per scope), `49400587` Nautilus 5-Year-Old Brain Organoids 1 pt top (organoid/3Brain substring-noise duplicate; 3rd neural-organoid HN signal in 11 pulls; flagged-for-traceability rather than promoted because 1-pt engagement is below the 5-pt Wired + 18-pt Nature engagement thresholds that drove prior `class-organoid-3d-bioprinting` Last-seen refreshes), `49401549` Anthropic Claude Code A/B testing reduced effort levels 29 pts top (4th Claude Code traceability entry in 14 days; adjacent-not-promoted per scope — Claude Code is not on Robin's named stack), `49394496` "Three important steps in my maturation process" 199 pts best (Thomas Dullien personal-blog essay; adjacent-not-promoted per scope — off-scope per scope discipline), `49397947` "Embedded AI" 29 pts top (No Starch Press book publication; adjacent-not-promoted per scope — book publication, not a vendor stack change). The 2026-08-20 pull (prior-prior) produced the `class-organoid-3d-bioprinting` theme-row Last-seen refresh 2026-08-12 → 2026-08-20 via the recurrence criterion (the `49366519` Nature organoid-time-passage paper 18 pts + `49373812` Science Alert cross-walk — second neural-organoid HN signal in 9 pulls); that refresh carries forward unchanged into the 2026-08-22 pull because the `49400587` Nautilus 5-Year-Old Brain Organoids 1-pt substring-noise duplicate qualifies for the recurrence criterion but 1-pt engagement is below the 5-pt Wired + 18-pt Nature thresholds. All eight 2026-08-22 adjacents stay adjacent-not-promoted per scope discipline. Evidence at [/sources/hackernews.md](/sources/hackernews.md). |
-| Git repo | **active** (`obsidian-robin`) | local repo path | Local Obsidian vault under `~/.openclaw/workspace`. Writes compact manifest; repo itself is source of truth. Evidence at [/sources/git-repo.md](/sources/git-repo.md). |
+| Git repo | **active** (`git-repo-1`) | local repo path | Local Obsidian vault at `/home/ldw/workspace` + OpenWiki wiki at `/home/ldw/.openwiki/wiki` (two configured repos per `~/.openwiki/connectors/git-repo/config.json`). Writes compact manifest; repo itself is source of truth. Evidence at [/sources/git-repo.md](/sources/git-repo.md). Last updated 2026-08-22 18:13 UTC — **0 new vault commits in the 24-hour window** (vault silent for the 6th consecutive fetch; the 2026-08-16 Quintard 2024 + Guo 2026 cluster remains the most recent vault activity, **6 calendar days stale**); 2 new automated wiki commits since the 2026-08-21 fetch (`d8e2277` daily update 2026-08-22 + `43d4548` sources-sync 2026-08-22, the **eighth** consecutive sources-sync re-applying the 2026-08-15 count-data wipe pattern after `997b648` 2026-08-16 + `be49285` 2026-08-17 + `1fc73ae` 2026-08-18 + `dcb53a2` 2026-08-19 + `bd30339` 2026-08-20 + `f6c2576` 2026-08-21 + now `43d4548` 2026-08-22). |
 ## How new source pages get created
@@ -31,4 +40,4 @@ When a connector ingests for the first time, an update run will:
 2. Create `/sources/<connector>.md` with the ingestion manifest, freshness, and compact evidence notes.
 3. Route durable items into the canonical pages and add a row in `/themes.md` if a recurring signal emerges.
-Until then, the new connector only has a row in the active connectors table above and no evidence page of its own.
+Until then, the new connector only has a row in the active connectors table above and no evidence page of its own..its own...
@@ -1,9 +1,16 @@
 ---
 type: "Reference"
 title: "Agents 代理商档案索引 — 跨 agent CRM 同步"
 description: "Cross-agent index of the Obsidian vault 02-Clients/Agents/* profiles (which agents Robin is actively working with, mapped by vendor product line). Base identity only — sensitive fields (phone / WeChat / email / end-customer list / opportunity value) live only in the private vault. Updated 2026-08-07 with _known_associations.md product-line → agent → end-customer mapping."
 tags: [agents, distributors, crm, celvivo, 3brain, cellink, femtobiomed, source]
 ---
 # Agents 代理商档案索引 — 跨 agent CRM 同步
 > 数据源: Obsidian vault `02-Clients/Agents/*.md` (git-repo connector 自动同步)
 > 用途: MiniMax code / Hermes 跨 agent 问 "Robin 当前在跟哪些代理商 / 谁在帮推什么产品"
 > 更新: 自动（`~/.openwiki/update-sources.sh` 每天 02:00 拉一次 mtime,数据写入本页后 commit + push Gitea）
-> 上次同步: **2026-07-28**
+> 上次同步: **2026-07-28** (current); 2026-08-07 hook 4 partial resolution via `_known_associations.md` (see below)
 ## 4 大产品线
@@ -18,7 +25,7 @@
 | 姓名 | 角色 | 代理商品牌 | 主推产品 | 首次记录 | 状态 | Vault 路径 |
 |---|---|---|---|---|---|---|
-| 董慧群 | 技术同事 | 待补 | CelVivo (ClinoStar / ClinoReactor) | 2026-07-28 | active | `02-Clients/Agents/董慧群.md` |
+| 董慧群 | 技术同事 | 待补 (8-07 hook 4 候选: **济南成全生物科技 (曹沛起)**) | CelVivo (ClinoStar / ClinoReactor) | 2026-07-28 | active | `02-Clients/Agents/董慧群.md` |
 ## 跟其他工具的互补关系
@@ -50,3 +57,17 @@
 - **02-Clients/Agents/** 现只有 1 个条目 — Robin 大部分代理商应该是已有的，需要主动说"把 X 也加进来"
 - 建议 Robin 每接一个新代理商 / 新联系人时 1 句话提示，我立即同步两边
 - 是否要加 **End-Customers/** 同步索引到 OpenWiki（按同样模式）？目前 `02-Clients/End-Customers/西南医科大学心研所-殴贤红.md` 已存在但未在本文件列
 ## 2026-08-07 关联索引 (Hermes hook 4)
 `02-Clients/Agents/_known_associations.md` (commit `4b237a82`, Hermes Agent 2026-08-07 hook 4) maps 现有关联 to 259-dealer 2026-08-07 baseline. Public index (privacy rule preserved):
 | 产品线 | 关联代理 / 中间方 | 关联客户 / 商机 |
 |---|---|---|
 | CelVivo | **济南成全生物科技 (曹沛起)** — 华北 + 山东 跨区 | 董慧群 (技术同事) — 8-07 候选 |
 | FemtoBiomed | **9X Bio (汇佰生物)** — 中间方 (不在 259 dealer list) | TriArm Therapeutics (翁靖傑 上海 CGT/CAR-T, 128 万 Phase1 / 8-10 至 8-14 现场 demo) |
 | 3Brain | 0 家代理 | 11+ end-customer dossiers (西南医大 殴贤红 pending 成都 dealer 2选1) |
 | Cellink | 0 家代理 | — |
 | FemtoBiomed (direct) | 0 家代理 | (9X Bio 中间方 handles) |
 See [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) § "8-07 新增" for full mapping + 待补缺口. Open-question `agent-dong-huiqun-celvivo` and commitment `dong-huiqun-ji-nan-chengquan-link` track the 董慧群 → 济南成全 confirmation.
@@ -0,0 +1,182 @@
 ---
 type: "Reference"
 title: "全国经销商地图 (2026-08-07 时点)"
 description: "Compact index of Robin's 2026-08-07 China distributor baseline (259 dealers across 7 regions, replacing 261 in the 2026-07-24 baseline) plus the new product-association index _known_associations.md. Surfaces CelVivo ClinoStar → 济南成全 + FemtoBiomed CellShot → 9X Bio → TriArm Therapeutics chain. Routes pricing-sensitive fields to the private Obsidian vault per /sources/agents.md privacy rule."
 resource: "/home/ldw/workspace/02-Clients/Agents/全国经销商地图-2026-0807.md"
 tags:
  - distributors
  - china
  - 2026
  - vendors
  - source
 ---
 # 全国经销商地图 · 2026-08-07 时点
 > **数据源**: Obsidian vault `02-Clients/Agents/*.md`（git-repo connector 自动同步，2026-08-07 写入 — 替换 2026-07-24 baseline）
 > **覆盖范围**: 全国 7 大区域 / **259** 家生命科学仪器经销商（汇总表口径；明细表 261：差 2 家 = 华北表 74 vs 汇总 72）
 > **整理**: Hermes Agent（Robin 2026-08-07 11:11 上传 `b7f52af896c1e3a9.xlsx`）
 > **关联索引**: `02-Clients/Agents/_known_associations.md`（2026-08-07 added — 5 命中产品-代理映射）
 ## 隐私边界
 按 [`/sources/agents.md`](/sources/agents.md) 既定规则，本文件**只含基础身份**：
 - ✅ 公司名 / 区域 / 主营品牌关键词 / 主战场
 - ❌ **不**含：电话 / 微信 / 邮箱 / 联系人姓名 / 终端客户清单 / 商机金额 / 销售人数
 **详细联系方式** → 必须读 Obsidian vault `02-Clients/Agents/{区域}-2026-0807.md`（git 私有）
 ## 关键统计
 | 维度 | 数值 |
 |---|---|
 | 总经销商数 | **259** 家（汇总表口径；明细表 261 — 差 2 家 = 华北表 74 vs 汇总 72）|
 | 覆盖区域 | 7 大区 |
 | 平均每地区 | 37 家 |
 | 上次 baseline | 2026-07-24（261 家） |
 | 净变更 | -2 家（华北：74 → 72） |
 | 地区 | 家数 (8-07) | 家数 (7-24) | 净变更 | 主战场 |
 |---|---:|---:|---:|---|
 | 华北 | 72 | 74 | -2 | 北京 (54家) |
 | 华东 | 68 | 68 | 0 | 上海 (53家) |
 | 华南 | 62 | 62 | 0 | 广州 (44家) |
 | 山东 | 25 | 25 | 0 | 济南 (22家) |
 | 湖北 | 19 | 19 | 0 | 武汉 (12家) |
 | 西北 | 6 | 6 | 0 | 西安 (6家) |
 | 西南 | 7 | 7 | 0 | 重庆 (3家) |
 | **TOTAL** | **259** | **261** | **-2** | — |
 ### 8-07 baseline 独有的数据异常
 - **济南成全生物科技有限公司 (曹沛起)** 同时登记在 **华北表 + 山东表**（geographic
  cross-region duplicate，合法 — 山东公司辐射华北是常见经销模式）。 This is the
  **only CelVivo ClinoStar agent** in the 259-dealer list — the hook to
  cross-reference with `02-Clients/Agents/董慧群.md`（见
  [`/open-questions.md`](/open-questions.md) `agent-dong-huiqun-celvivo`）
 - **华北表 序号 63 / 67** 两个空 company-name 字段（继承 from 2026-07-24
  baseline）；明细表 74 vs 汇总表 72 的差 2 家，就是这 2 行
 ## 与 4 大产品线的潜在关联
 > 以下统计仅展示**代理过我们 4 大产品线品牌**的经销商家数。**不等于**Robin 实际在跟的代理商 — 那份见 [`/sources/agents.md`](/sources/agents.md)。
 | 产品线 | 涉及品牌 | 全国关联经销商数 | 8-07 命中 |
 |---|---|---:|---|
 | CelVivo (ClinoStar / ClinoReactor) | CelVivo / ClinoStar | 1 | **济南成全生物科技 (曹沛起)** — 华北 + 山东 (跨区重复) |
 | FemtoBiomed (CellShot / PROLIVA) | Femtobiomed / CellShot | 0 | (9X Bio / 汇佰生物 is direct intermediate, 不在 259 dealer list) |
 | 3Brain (HD-MEA) | 3Brain | 0 | — |
 | Cellink (BIO X) | Cellink | 0 | — |
 **详细 + 客户-代理映射：** 见 `02-Clients/Agents/_known_associations.md`（2026-08-07 added）。
 ## 详细分地区索引（不含敏感字段）
 - 华北 (72 家) — 见 Obsidian vault `02-Clients/Agents/华北-2026-0807.md`
 - 华东 (68 家) — 见 Obsidian vault `02-Clients/Agents/华东-2026-0807.md`
 - 华南 (62 家) — 见 Obsidian vault `02-Clients/Agents/华南-2026-0807.md`
 - 山东 (25 家) — 见 Obsidian vault `02-Clients/Agents/山东-2026-0807.md`
 - 湖北 (19 家) — 见 Obsidian vault `02-Clients/Agents/湖北-2026-0807.md`
 - 西北 (6 家) — 见 Obsidian vault `02-Clients/Agents/西北-2026-0807.md`
 - 西南 (7 家) — 见 Obsidian vault `02-Clients/Agents/西南-2026-0807.md`
 > **2026-07-24 baseline 文件** (`*2026-0724.md` × 7 + `全国经销商地图-2026-0724.md`) 仍 in repo but 已被 8-07 替换。Robin upload 2026-08-07 11:11 时是 **8-04 同名 + 新增 2-3 家** = 259 汇总口径。
 ## 品牌关键词地图（粗略）
 > 仅用于跨 agent 快速定位"哪类品牌主要被哪些地区代理"。**完整品牌名见 vault。**
 | 品牌 | 全国 | 华北 | 华东 | 华南 | 山东 | 湖北 | 西北 | 西南 |
 |---|---|---|---|---|---|---|---|---|
 | BI | 19 | 1 | 5 | 0 | 7 | 3 | 1 | 2 |
 | Thermo | 19 | 2 | 5 | 2 | 6 | 1 | 1 | 2 |
 | Bio-Rad | 11 | 0 | 4 | 0 | 3 | 1 | 1 | 2 |
 | 赛默飞 | 8 | 3 | 0 | 3 | 0 | 0 | 1 | 1 |
 | 安捷伦 | 7 | 2 | 0 | 2 | 3 | 0 | 0 | 0 |
 | 蔡司 | 6 | 1 | 1 | 4 | 0 | 0 | 0 | 0 |
 | Cytiva | 6 | 0 | 3 | 1 | 1 | 1 | 0 | 0 |
 | 伯乐 | 6 | 0 | 1 | 2 | 0 | 1 | 1 | 1 |
 | 徕卡 | 6 | 0 | 0 | 4 | 0 | 1 | 0 | 1 |
 | 赛多利斯 | 5 | 1 | 0 | 2 | 1 | 0 | 0 | 1 |
 | Eppendorf | 5 | 1 | 1 | 0 | 2 | 1 | 0 | 0 |
 | Leica | 5 | 0 | 1 | 0 | 1 | 1 | 0 | 2 |
 | Beckman | 4 | 0 | 3 | 0 | 1 | 0 | 0 | 0 |
 | Merck | 4 | 0 | 1 | 1 | 2 | 0 | 0 | 0 |
 | Waters | 4 | 0 | 1 | 0 | 2 | 0 | 0 | 1 |
 | Azure | 3 | 1 | 0 | 0 | 1 | 1 | 0 | 0 |
 | Bruker | 3 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
 | Oxford Nanopore | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 1 |
 | Agilent | 3 | 1 | 0 | 0 | 2 | 0 | 0 | 0 |
 | Sartorius | 3 | 1 | 0 | 0 | 1 | 0 | 0 | 1 |
 ## 8-07 新增：`_known_associations.md` 索引
 `02-Clients/Agents/_known_associations.md` 是 2026-08-07 由 Hermes Agent
 hook 4（4 个经销商管理 Hook 升级）输出的产品-代理-客户映射。摘录：
 ### CelVivo / ClinoStar 链
 | 项 | 内容 |
 |---|---|
 | 代理 | **济南成全生物科技有限公司 (曹沛起)** — 华北 + 山东 跨区重复登记 |
 | 关联中间方 | 董慧群 (CelVivo 技术同事) — agency 待 Robin 确认 |
 | 关联客户 | (待 Robin 确认) |
 | 关联商机 | (待 Robin 确认) |
 ### FemtoBiomed (CellShot / PROLIVA) 链
 | 项 | 内容 |
 |---|---|
 | 中间方 | **9X Bio (汇佰生物)** — FemtoBiomed CellShot / PROLIVA 中国中间方 |
 | 259 dealer 命中 | 0 家 (9X Bio 直接对接 TriArm, 不在代理渠道表里) |
 | 关联终端客户 | **TriArm Therapeutics (翁靖傑, 上海 CGT/CAR-T)** |
 | 关联商机 | `02-Active-Deals/CellShot-TriArm-Demo-*` (4 个文件, 7-17 会议 + 7-20 计划 v1/v2) |
 | 备注 | 128 万 Phase1 / 8-10 至 8-14 现场 demo |
 ### 西南医科大学心研所 殴贤红 → 2 选 1
 | 项 | 内容 |
 |---|---|
 | 地区 | 四川泸州 |
 | 候选代理 A | **成都百乐 (杨军)** — 覆盖川渝黔藏 · 1亿/钻石 · 主营 Bio-Rad/Sartorius/Oxford Nanopore/Cytek/Leica |
 | 候选代理 B | **成都立德赛** — 覆盖川渝云贵陕 |
 | 关联商机 | (待 Robin 决策) |
 | 推荐 | **先联系 成都百乐** (钻石级 1亿, 主营匹配度更高) |
 ### 产品线代理映射（259 dealer 表已知）
 | 产品线 | 命中代理 | 关联客户 |
 |---|---|---|
 | CelVivo | 济南成全 (曹沛起) | 董慧群关联 |
 | FemtoBiomed | 0 (9X Bio 中间方) | TriArm |
 | 3Brain | 0 | — |
 | Cellink | 0 | — |
 ### 待补缺口（Robin 优先补全）
 1. 董慧群 是 济南成全的哪个具体技术同事? 还是另一家代理?
 2. 西南医大 殴贤红 → 成都百乐 还是 成都立德赛?
 3. 邓昊伦 (02-Contacts/) 蛇类神经方向 → 3Brain HD-MEA 拜访?
 4. 259 dealer 表里**无 3Brain / Cellink 代理** → 缺销售漏掉了 or 要主动找?
 ## 与现有 sources/agents.md 关系
 - [`/sources/agents.md`](/sources/agents.md) 记录**Robin 实际在跟的代理商**（按 4 大产品线维度，目前 1 个: 董慧群）→ "在跟"
 - `/sources/distributors-china-2026.md`（本文件）记录**全国 259 家渠道全量 (8-07 baseline)** + 8-07 新增 `_known_associations.md` 索引 → "全景 + 关联"
 - 两份互补，**不可合并**：合并会污染"在跟"列表（混入未接触的 258 家）
 ## 关键数据缺口
 按汇总表"四、业务字段填写情况"，部分地区的关键业务字段填写率极低：
 - 华东营收填写率 **0/68 (0%)**
 - 湖北营收填写率 **0/19 (0%)**
 - 华南销售人数填写率 **0/62 (0%)**
 - 西北/西南/山东多数字段完整
 → 下次去这些地区拜访前，**优先补齐对应地区档案**。
 ---
 *由 Hermes Agent 自动整理 · 2026-08-07*
 *本文件不含敏感信息，按 [`/sources/agents.md`](/sources/agents.md) 隐私规则*
 *Raw manifest: `~/.openwiki/connectors/git-repo/raw/2026-08-08T18-11-31-856Z/manifest.json`*
@@ -1,3 +1,10 @@
 ---
 type: "Reference"
 title: "飞书邮箱 (Robin customer mailbox)"
 description: "Planned cross-agent mailbox sync target for Robin's Feishu (飞书) mailbox (imap.feishu.cn:993 / imap.larksuite.com:993) — would let MiniMax code / Hermes recall 'what did Robin last discuss with customer X' from email metadata + summaries. Not yet provisioned — IMAP credentials + update script + crontab still pending Robin setup; this page documents the planned configuration and the sync policy that will be applied once provisioned."
 tags: [feishu-mail, evidence-index, source, mailbox, planned, 2026-08-13]
 ---
 # 飞书邮箱 (Robin customer mailbox)
 > 数据源: Robin 的飞书邮箱 (imap.feishu.cn:993 或 imap.larksuite.com:993)
@@ -0,0 +1,29 @@
 # Files
 - [4-27 SOP 实战 vs 实现差异 (2026-07-27 Tasevska 2025 重做教训)](2026-07-27-4-27-sop-vs-implementation.md) - Lessons-learned capture from Robin's 2026-07-27 Tasevska 2025 EJPS deep-read redo — 9-step comparison table of 4-27 SOP范本 vs 7-27 凭印象实操 (Tasevska + Raji 2 篇) vs 4-27 SOP 走通 (Tasevska 重做); detailed PyMuPDF 嵌入图过滤 rules, Ollama 视觉 fallback chain, NocoDB v1 vs v2 protocol, and the 9-step mandatory format. Applies to every literature-deep-read invocation. Companion to `/sources/ldr-report-template.md`.
 - [Agents 代理商档案索引 — 跨 agent CRM 同步](agents.md) - Cross-agent index of the Obsidian vault 02-Clients/Agents/* profiles (which agents Robin is actively working with, mapped by vendor product line). Base identity only — sensitive fields (phone / WeChat / email / end-customer list / opportunity value) live only in the private vault. Updated 2026-08-07 with _known_associations.md product-line → agent → end-customer mapping.
 - [全国经销商地图 (2026-08-07 时点)](distributors-china-2026.md) - Compact index of Robin's 2026-08-07 China distributor baseline (259 dealers across 7 regions, replacing 261 in the 2026-07-24 baseline) plus the new product-association index _known_associations.md. Surfaces CelVivo ClinoStar → 济南成全 + FemtoBiomed CellShot → 9X Bio → TriArm Therapeutics chain. Routes pricing-sensitive fields to the private Obsidian vault per /sources/agents.md privacy rule.
 - [飞书邮箱 (Robin customer mailbox)](feishu-mail.md) - Planned cross-agent mailbox sync target for Robin's Feishu (飞书) mailbox (imap.feishu.cn:993 / imap.larksuite.com:993) — would let MiniMax code / Hermes recall 'what did Robin last discuss with customer X' from email metadata + summaries. Not yet provisioned — IMAP credentials + update script + crontab still pending Robin setup; this page documents the planned configuration and the sync policy that will be applied once provisioned.
 - [Git repo — evidence index (Obsidian vault, Robin)](git-repo.md) - Compact manifest of Robin's Obsidian vault + the local OpenWiki wiki, ingested through the local git-repo connector. Two configured repos: obsidian-vault at /home/ldw/workspace (main branch, HEAD a4fa5a32, 2026-08-16, **0 new vault commits in the 2026-08-21T18:09Z → 2026-08-22T18:13Z 24-hour window — vault is silent for the 6th consecutive fetch after the 2026-08-16 Quintard + Guo cluster, 6 calendar days stale**) and openwiki-wiki at /home/ldw/.openwiki/wiki (main branch, HEAD 43d4548, 2026-08-22, **2 new automated wiki commits in the 2026-08-21T18:09Z → 2026-08-22T18:13Z window: `d8e2277` daily update 2026-08-22 + `43d4548` sources-sync 2026-08-22 — the eighth consecutive sources-sync re-applying the 2026-08-15 count-data wipe pattern**). This page is a navigation index — content ingestion (paper deep reads, sales scripts, customer files) happens via the Hermes skill and RAGFlow, not here.
 - [Hacker News — evidence index](hackernews.md) - Compact evidence trail for the Hacker News connector (hackernews-1, Robin-curated life-sciences + AI workflow). Synthesis lives on /themes.md, /commitments.md, etc.; this page only records ingestion coverage and notable items.
 - [文献精读 Master Template (Robin 7-27 实战版, "真适合浏览" 1 文件)](ldr-report-template.md) - Master template for Robin's literature-deep-read (LDR) pipeline — consolidates 4 literature skills (`literature-deep-read` / `research` / `review` / `curation-for-sales`) into a single 8-rule + 3-trigger + 5-section "真适合浏览" report format. Synthesized from 4-27 SOP范本 + 7-27 实战 lessons (Tasevska / Raji / Bosnjakovic). Triggers "精读吧" / "发 wikijs" / "入库" / "A" / Id/DOI/PMID/PDF signals into 4-step精简 or 8-step完整 flows. PDF全文必传 + PyMuPDF xref去重 + 9项强制 + SeaFile hostname `fb.biokingdom.top` + NocoDB v1 JSON + 3张真图 + `journal-year-topic` 报告路径.
 - [Bosnjakovic 2025 PAH 3D 球体代谢组学: 跟 CelVivo ClinoStar dynamic culture 关系 (Bosnjakovic 2025 bioRxiv)](literature-cel-bosnjakovic-2025-pah-deepread.md) - Deep-read synthesis of Bosnjakovic A et al. 2025 bioRxiv preprint (DOI 10.1101/2025.07.10.663939v1, 2025-07-10) — 21-day mature HepG2 3D spheroids with graded non-cytotoxic BaP + BBF (PAH代表物) exposure for metabolomics biomarker discovery. Robin's connection: 3D spheroid protocol maps directly onto CelVivo ClinoStar dynamic culture; supports PAH exposure metabolomics positioning for hepatotoxicity / NAFLD modeling applications. 精读 2026-07-27.
 - [CelVivo 2026 脑类器官白皮书《Breaking the Bias》精读索引](literature-celvivo-brain-whitepaper-2026.md) - Deep-read synthesis of CelVivo ApS (Denmark) 2026 whitepaper 'Breaking the Bias: Addressing the challenges facing optimal neural organoid development' (16 pages, translated + 精读 2026-07-28). Synthesizes CelVivo's positioning on neural organoid long-term culture and the clinical-translation path. Direct vendor-channel evidence for the CelVivo ClinoStar / ClinoReactor portfolio on brain organoid applications — companion to academic literature flywheel-sync.
 - [Liu 2026 — shape-conformal porous frameworks for full coverage of neural organoid electrophysiology (Nat Biomed Eng, Rogers Lab)](literature-liu-2026-nbme-shape-conformal-organoid-deepread.md) - Deep-read synthesis of Liu N et al. (2026) Nature Biomedical Engineering — shape-conformal porous framework + adaptive genetic algorithm + flexible-electronics microlattice for full-surface (>90%) neural organoid electrophysiology at 3000-8000 channels per organoid (vs 200-1000 traditional MEA); weeks-long stable recording; epilepsy/AD disease modeling.
 - [Miao 2025 — co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids (Cell v2)](literature-miao-2025-cell-vascularization-v2-deepread.md) - Deep-read synthesis of Miao Y et al. (2025) Cell v2 — single 3D EB co-induction of mesoderm+endoderm yields vHLPO with 7% ECs vs traditional 0%; FOXF1 mutation ACDMPV disease modeling; lung + gut organoid vascularization.
 - [Raji 2026 (hMOs + 3Brain HD-MEA) — 7-27 增补版 (跟 7-01 矩阵集成)](literature-raji-2026-deepread.md) - Deep-read synthesis of Raji H, Bertoli F, Perez MJ, Lam A, Volpicelli-Daley LA, Deleidi M. 2026 Molecular Psychiatry (Nature 子刊, s41380-026-03667-4, DOI 10.1038/s41380-026-03667-4, IF 11) — human midbrain organoids (hMOs) with WNT modulation, dopaminergic neuron differentiation, bioreactor culture, and 3Brain HD-MEA electrophysiology for Parkinson's disease modeling. 7-01 实战范本 (page 1622) + 7-27 增补版 integrated with 3-paper 3Brain MEA matrix (Raji / Pali / Wei) and 4 product-line complementarity chain (CelVivo ClinoStar + Cellink BIO X + 3Brain HD-MEA + FemtoBiomed CellShot).
 - [Sharma 2026 — vascularized retinal organoid RGC survival and maturation (Cell Stem Cell)](literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md) - Deep-read synthesis of Sharma K et al. (2026) Cell Stem Cell — transiently vascularized human retinal organoids with RGC 18.2% vs ctrl-RO 1.21% at week 18, W31 ON/OFF/ON-OFF light responses, C3 endothelial monolayer integration strategy.
 - [3D 打印缓释 HCTZ 片: 跟 Cellink BIO X 挤出打印 (Tasevska 2025 EJPS)](literature-tasevska-2025-deepread.md) - Deep-read synthesis of Tasevska T et al. 2025 European Journal of Pharmaceutical Sciences 206:106998 (DOI 10.1016/j.ejps.2024.106998, 精读 2026-07-27) — first systematic SSE semi-solid extrusion vs DLP digital-light-processing comparison for sustained-release HCTZ (hydrochlorothiazide) tablets, with focus on SSE matching Cellink BIO X extrusion principle. Supports Robin's 3D-printed personalized-dose / sustained-release positioning and SSE extruder cross-sell narrative for Cellink BIO X accounts.
 - [Literature Deep-Reads — cross-agent deep-read index](literature.md) - Cross-agent index of Robin's literature deep-reads across the 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed) and adjacent application domains (organoid IRB / ethics, vascularized organoids, microfluidic / organ-on-chip). Backed by the Obsidian vault 04-Literature/Deep-Reads/ and the flywheel-sync pipeline; synthesis pages are linked per paper.
 - [NocoDB 文献库索引 — 跨 agent 数据层](nocodb.md)
 - [OpenWiki Upgrade Drift (auto-generated)](openwiki-version-drift.md)
 - [OpenWiki 速查手册 (Robin 一次聊清, 直接拿来用)](OpenWiki%E9%80%9F%E6%9F%A5%E6%89%8B%E5%86%8C.md) - Compact OpenWiki cheat-sheet that condenses the 2026-07-27 6-conversation walkthrough into a single ready-to-share document. Designed for one-shot delivery to any agent / colleague / customer / manager who asks 'what is OpenWiki?' — covers the core concept, structure, sync model, and 4 active connectors in one page.
 - [RAGFlow 文档采样索引](ragflow-documents.md) - Document-level sample index of Robin's RAGFlow instance (http://10.10.10.254:9980) — 18 KBs / 32709 total docs / 401 sample entries (last sync 2026-08-03). Captures the 30-doc-per-request server-side limit + offset bug that forces 12 large KBs to single-page samples. Lets MiniMax code / Hermes see 'what's in each KB' without SQL queries; complements `/sources/ragflow.md` (KB-level health + counts).
 - [RAGFlow 全文检索索引 (Robin KB system)](ragflow.md)
 - [Sources](README.md) - Per-connector evidence indexes and ingestion coverage for the local knowledge wiki; durable synthesis lives on canonical pages.
 - [RustDesk 自建 hbbs 完整配置笔记 (2026-08-05)](rustdesk-sop.md) - End-to-end deployment note for Robin's self-hosted RustDesk relay server (hbbs + hbbr) — Unraid NAS container (10.10.10.254) + OpenWrt reverse-proxy (10.10.10.252) + Tencent Light Cloud (43.160.207.177) + ITX client (192.168.31.14), with permanent password + key config. Supports remote control of the ITX 24h host (per `/commitments.md` `itx-24h-host-build-2026-q3`) and Robin's travel-laptop remote-access workflow.
 - [CelVivo 销售弹药清单 (2026-07-16 实战索引)](sales-ammunition.md) - Sales ammunition index for CelVivo ClinoStar / ClinoReactor — price-book SKUs (ClinoReactor 12-pack, ClinoStar, SP5D-24W, Demo kit), 8-protocol SOP series (ClinoReactor prep / media change / organoid gardening / speed-tuning / alginate / VitroGel), and 5 organ-specific application cases (HepG2, FTC-133, SCLC, TNBC, ClinoStar vs Orbital Shaker). Sources from RAGFlow CelVivo KB + CelVivo commercial KB; manually curated from Robin + Hermes 实战 lessons. Used by any agent answering CelVivo ClinoReactor pricing / demo / customer-pitch queries.
 - [SeaFile 大文件存储索引](seafile.md)
 - [CelVivo + Vault 实时 mtime 快照 (2026-07-16 快照)](vault-mtime-snapshot-2026-07-16.md) - Historical mtime snapshot of Robin's Obsidian vault from 2026-07-16 — captures CelVivo deep-read activity (0 new entries in the 7-day window 2026-07-09 → 2026-07-16; last activity 2026-07-05), 6 entries in the 30-day window, and ClinoReactor keyword hits. Provides a baseline reference for cross-agent vault state because WSL laptop vault is not directly readable from container agents. Pre-dates the 2026-08-07 distributor refresh + 2026-08-12 Liang 2026 / 2026-08-13 Review/ subfolder activity — superseded by `/themes/05-robin-research.md` for current vault state.
 - [Web Search Evidence](web-search.md) - Compact, source-backed evidence and ingestion coverage for the web-search-1 Tavily lane tracking CelVivo, 3Brain, Cellink, and related organoid news.
 - [Wiki.js 索引 — 跨 agent 文档发布层](wikijs.md)
@@ -1,3 +1,10 @@
 ---
 type: "Reference"
 title: "文献精读 Master Template (Robin 7-27 实战版, \"真适合浏览\" 1 文件)"
 description: "Master template for Robin's literature-deep-read (LDR) pipeline — consolidates 4 literature skills (`literature-deep-read` / `research` / `review` / `curation-for-sales`) into a single 8-rule + 3-trigger + 5-section \"真适合浏览\" report format. Synthesized from 4-27 SOP范本 + 7-27 实战 lessons (Tasevska / Raji / Bosnjakovic). Triggers \"精读吧\" / \"发 wikijs\" / \"入库\" / \"A\" / Id/DOI/PMID/PDF signals into 4-step精简 or 8-step完整 flows. PDF全文必传 + PyMuPDF xref去重 + 9项强制 + SeaFile hostname `fb.biokingdom.top` + NocoDB v1 JSON + 3张真图 + `journal-year-topic` 报告路径."
 tags: [ldr-template, literature-deep-read, sop, reference, 2026-08-13]
 ---
 # 文献精读 Master Template (Robin 7-27 实战版, "真适合浏览" 1 文件)
 > **目标**: 这份是 Robin 跟 4 大 literature skill (`literature-deep-read` / `research` / `review` / `curation-for-sales`) 之间的 "**唯一 1 个 master 文件**" — 取代 4 大 skill 6000+ 行, Robin 只看这 1 份就够.
@@ -22,7 +29,7 @@
 | 3. **9 项强制 + 创新点/局限性/学术启示 3 段** (4-27 SOP page 946 标杆) | 7-27 教训 (7-17 2 篇缺 3 段) | 模板下面 §3 |
 | 4. **SeaFile URL hostname `fb.biokingdom.top`** (不是少 o) | 7-27 教训 (Tasevska 5 URL 错) | 验证 share-link 真能开 |
 | 5. **NocoDB v1 + JSON body** (4-27 SOP 实战新发现, 范本 v2 失败 3 次) | 7-27 Tasevska 入库 | `POST /api/v1/db/data/wzg1wtad/p2z4g0s687axyvu/{table_id}` |
-| 6. **3 张真图 `![]()`** (SeaFile URL), 不**只**文字图说啥 | 7-27 教训 (Tasevska 重做/Raji 增补版漏图) | `!\[alt\](url)` markdown, 3 段三段式图注 |
+| 6. **3 张真图 `![]()`** (SeaFile URL), 不**只**文字图说啥 | 7-27 教训 (Tasevska 重做/Raji 增补版漏图) | markdown image syntax (`alt text` + parenthesized URL), 3 段三段式图注 |
 | 7. **报告路径 `journal-year-topic` (4-27 SOP 范本)** | 7-27 教训 (我用过 `tasevska-2025-3d-printed-hctz` 不规范) | `ejps-2025-hctz-sse-3d-printing` 风格 |
 | 8. **精简 4 步 vs 完整 8 步按 Robin 信号自动判断** | 7-27 实战 (Tasevska 简化 App Note 类) | 模板下面 §2 |
@@ -1,3 +1,10 @@
 ---
 type: "Reference"
 title: "Bosnjakovic 2025 PAH 3D 球体代谢组学: 跟 CelVivo ClinoStar dynamic culture 关系 (Bosnjakovic 2025 bioRxiv)"
 description: "Deep-read synthesis of Bosnjakovic A et al. 2025 bioRxiv preprint (DOI 10.1101/2025.07.10.663939v1, 2025-07-10) — 21-day mature HepG2 3D spheroids with graded non-cytotoxic BaP + BBF (PAH代表物) exposure for metabolomics biomarker discovery. Robin's connection: 3D spheroid protocol maps directly onto CelVivo ClinoStar dynamic culture; supports PAH exposure metabolomics positioning for hepatotoxicity / NAFLD modeling applications. 精读 2026-07-27."
 tags: [literature-deep-read, celvivo-clinostar, hepG2, PAH, metabolomics, 3d-spheroid, 2026-08-13]
 ---
 # Bosnjakovic 2025 PAH 3D 球体代谢组学: 跟 CelVivo ClinoStar dynamic culture 关系 (Bosnjakovic 2025 bioRxiv)
 > Bosnjakovic A, Eichmann TO, Stern A, et al. | **bioRxiv** (preprint) | 2025-07-10 | DOI: 10.1101/2025.07.10.663939v1 (biorxiv 2025.07.10) | 精读 2026-07-27
@@ -1,3 +1,10 @@
 ---
 type: "Reference"
 title: "CelVivo 2026 脑类器官白皮书《Breaking the Bias》精读索引"
 description: "Deep-read synthesis of CelVivo ApS (Denmark) 2026 whitepaper 'Breaking the Bias: Addressing the challenges facing optimal neural organoid development' (16 pages, translated + 精读 2026-07-28). Synthesizes CelVivo's positioning on neural organoid long-term culture and the clinical-translation path. Direct vendor-channel evidence for the CelVivo ClinoStar / ClinoReactor portfolio on brain organoid applications — companion to academic literature flywheel-sync."
 tags: [literature-deep-read, celvivo, brain-organoid, clinostat, long-term-culture, whitepaper, vendor-channel, 2026-08-13]
 ---
 # CelVivo 2026 脑类器官白皮书《Breaking the Bias》精读索引
 > **CelVivo ApS (Denmark) | 2026 白皮书 | 16 页 | 翻译精读 2026-07-28**
@@ -0,0 +1,110 @@
 ---
 type: "Reference"
 title: "Liu 2026 — shape-conformal porous frameworks for full coverage of neural organoid electrophysiology (Nat Biomed Eng, Rogers Lab)"
 description: "Deep-read synthesis of Liu N et al. (2026) Nature Biomedical Engineering — shape-conformal porous framework + adaptive genetic algorithm + flexible-electronics microlattice for full-surface (>90%) neural organoid electrophysiology at 3000-8000 channels per organoid (vs 200-1000 traditional MEA); weeks-long stable recording; epilepsy/AD disease modeling."
 tags: [literature, deep-read, neural-organoid, hd-mea, flexible-electronics, microlattice, 3d-bioprinting-adjacent, celvivo-clinostar-adjacent, 3brain-hd-mea, robin-picked-papers]
 ---
 # Liu 2026 — shape-conformal porous frameworks for full coverage of neural organoid electrophysiology (Nat Biomed Eng, Rogers Lab)
 > Liu N, Shiravi S, Jin T, Liu J, Zhu Z, Li J, Cheung I, Zhang H, Wang Y, Li Q, Xu Z, Zeng L, ... Rogers JA. | **Nature Biomedical Engineering** | 2026 | DOI: 10.1038/s41551-026-01620-y
 > Wiki.js Id 1692 — https://wiki.biokingdom.top/zh/literature/liu-2026-nbme-shape-conformal-organoid
 > NocoDB row 1 in **new table `Robin_Picked_Papers`** (created 2026-08-08, table_id `mbjo0wb56qv1qly`)
 > SeaFile PDF: https://fb.biokingdom.top/f/6da50240729e41bdb369/?dl=1 (5 figures)
 > Deep-read date: 2026-08-08; flywheel-sync `flywheel_index` completed 2026-08-08T09:59:40Z
 > Vendor deep-read report: `/home/ldw/workspace/Liu2026_NBME_shape_conformal_organoid.md`
 **Tags:** neural organoid | shape-conformal framework | flexible electronics | adaptive genetic algorithm | microlattice | 3D bioprinting adjacent | HD-MEA next-gen | electrophysiology | epilepsy disease modeling | Alzheimer disease modeling | Rogers Lab (Northwestern)
 **Special note:** This is the **first entry** in the new NocoDB table `Robin_Picked_Papers`, created 2026-08-08 per Robin's instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage. The table is separate from the existing `Organoid_Literature` table.
 ---
 ## 0. Research background and core question
 **Background:** Traditional multi-electrode arrays (MEAs) record neural organoid electrophysiology from a flat 2D electrode grid sitting at the bottom of the organoid — capturing only the bottom-surface electrical activity (5-15% of the organoid surface). This is fundamentally limiting for understanding 3D neural network dynamics. **This study** (Rogers Lab, Northwestern) introduces a **shape-conformal porous framework** that wraps the entire organoid surface (2D → 3D buckling transition) and provides >90% surface coverage at 3000-8000 channels per organoid.
 **Core questions:**
 - Can a flexible-electronics framework be designed to conformally wrap a 3D organoid?
 - What channel density and surface coverage does the framework achieve vs traditional MEA?
 - Can the framework record weeks-long stable signals without mechanical or electrical failure?
 - Can bi-directional electrical stimulation + optogenetic stimulation be integrated?
 - Can the framework detect disease-network signatures (epilepsy, AD) in patient-derived organoids?
 ## 1. Key findings (4-paragraph three-segment format — 4-27 SOP standard)
 ### Key finding 1: Shape-conformal porous framework gives >90% surface coverage (vs 5-15% traditional MEA)
 | What was done | What was found | What it means |
 | --- | --- | --- |
 | Inverse design + Euler-Bernoulli beam theory + adaptive genetic algorithm (AGA); 2D flexible-electronics film → 3D framework via automatic buckling | >90% full surface coverage vs 5-15% traditional MEA; 3000-8000 channels per organoid (vs 200-1000); framework conforms to organoid shape without compression | First 3D electrophysiology platform that captures the **whole-organoid** electrical activity — enables true 3D neural network dynamics analysis rather than bottom-surface-only |
 ### Key finding 2: Weeks-long stable recording
 | What was done | What was found | What it means |
 | --- | --- | --- |
 | Continuous recording over 4+ weeks in vitro; bi-directional electrical stimulation (evoked responses); optogenetic stimulation compatibility | Recording stable through weeks (no mechanical failure, no signal drift); bi-directional electrical stimulation produces expected evoked responses; optogenetic stimulation + recording compatibility | First platform that supports **long-term drug screening** — 4-week drug exposure with continuous electrophysiology readout was previously impossible |
 ### Key finding 3: Epilepsy + Alzheimer's disease modeling
 | What was done | What was found | What it means |
 | --- | --- | --- |
 | Patient-derived iPSC cortical organoids from epilepsy + Alzheimer's donors vs healthy controls | Disease-network signatures detected (epileptiform bursts, AD-specific oscillation patterns); drug screening proof-of-concept | Patient-derived organoid drug screening becomes a **first-tier preclinical model** for neurological disease — supports personalized medicine workflows |
 ### Key finding 4: 3D microlattice fabrication with PI/Parylene substrate
 | What was done | What was found | What it means |
 | --- | --- | --- |
 | Flexible-electronics thin film + microlattice patterning on PI/Parylene substrate; 2D-to-3D buckling transition | High-resolution microlattice with controlled porosity; mechanical compliance matched to neural tissue; optical transparency for optogenetics | The microlattice fabrication technique is a **3D bioprinting-adjacent** technology — bridges flexible-electronics manufacturing and tissue-engineering scaffold fabrication |
 ## 2. Methodology
 | Step | Content | Key parameters |
 | --- | --- | --- |
 | 1. Framework design | Inverse design + Euler-Bernoulli beam theory + adaptive genetic algorithm (AGA) | — |
 | 2. Fabrication | Flexible-electronics thin film + microlattice patterning | PI/Parylene substrate |
 | 3. Interface | 2D-to-3D automatic buckling transition (wraps organoid surface) | — |
 | 4. Recording | >90% surface coverage, 3000-8000 channels per organoid, 32 kHz sampling | Weeks-long stable |
 | 5. Stimulation | Bi-directional electrical + optogenetic | — |
 | 6. Validation | Human iPSC cortical organoids + long-term electrophysiology | 4+ weeks |
 | 7. Disease modeling | Epilepsy + AD patient-derived organoids | — |
 ## 3. Boundaries / Limitations
 - **Currently validated mainly in cortical organoids** — generalization to other organoid types (midbrain, spinal, retinal) not yet demonstrated.
 - **Framework fabrication is complex** — requires Rogers Lab's specialized flexible-electronics fabrication pipeline; not yet a turnkey product.
 - **Higher channel count → bigger data processing burden** — 3000-8000 channels at 32 kHz produces terabytes per week; new analysis pipelines required.
 - **Disease modeling validated only in epilepsy + AD** — extension to other neurological diseases (PD, HD, ALS) not yet published.
 ## 4. Product relevance (vendor cross-mapping)
 | Vendor / product | Rating | Evidence |
 | --- | ---: | --- |
 | **HD-MEA (3Brain or next-gen)** | **5** | 10-50× existing channels — Liu 2026's framework is the **direct next-generation design reference** for HD-MEA platforms. Robin should sell 3Brain's current 4096-electrode Accura-3D as the existing best-in-class and Liu 2026 as the forward-looking 3D-coverage direction |
 | **3D bioprinting (microlattice)** | **5** | The microlattice fabrication technique depends on 3D printing-class resolution. Cellink BIO X / Lumen X cannot directly print at this resolution today, but the field direction is clear: future bioprinters will integrate flexible-electronics fabrication |
 | **CelVivo ClinoStar** | 4 | Organoid culture downstream — Liu 2026's framework is a readout tool; ClinoStar is the culture partner. Long-term maturation + functional readout is the canonical ClinoStar → HD-MEA workflow |
 | **Flexible electronics** | 4 | PI/Parylene substrate stack is standard flexible-electronics material science — not Robin's vendor line directly but the methodology is in scope for the broader Cellink / BIONOVA product family |
 | **Patient-derived organoid drug screening** | **5** | First long-term high-throughput electrophysiology drug screening platform. Patient-derived organoid drug screening becomes feasible for neurological disease at scale |
 ## 5. Why this matters for Robin's portfolio
 - **Highest product-relevance cluster of all 3 flywheel-sync papers.** Two rating-5 products (HD-MEA + 3D bioprinting) and three rating-4 products (CelVivo ClinoStar, flexible electronics, patient-derived drug screening) all converge on Liu 2026's framework.
 - **3Brain HD-MEA roadmap signal:** Liu 2026 establishes a **next-gen 3D-coverage HD-MEA design** that 3Brain will need to respond to. Robin should track whether 3Brain has a flexible-electronics / shape-conformal framework on their roadmap.
 - **3D bioprinting cross-sell:** the microlattice fabrication technique is a 3D bioprinting-adjacent technology — Robin should pitch Liu 2026 to Cellink to understand whether BIONOVA X or Lumen X can fabricate flexible-electronics-compatible microlattices.
 - **Patient-derived organoid drug screening pipeline:** Liu 2026 + Miao 2025 together establish a complete pipeline — CelVivo ClinoStar culture → HD-MEA / shape-conformal framework readout → patient-derived drug screening. Robin's 4-vendor portfolio (CelVivo / 3Brain / Cellink / Femtobiomed) covers every link.
 - **First entry in `Robin_Picked_Papers` table:** new NocoDB table created 2026-08-08 per Robin instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage. This is a structural change in the literature pipeline.
 ## 6. Forward / 转发语 + 落款
 > Liu 2026 是 neural organoid 全表面电生理首篇 — **形状共形多孔框架 + 3000-8000 通道 / 类器官 (>90% 全表面覆盖) vs 传统 MEA 5-15% (200-1000 通道)**, 数周稳定记录 + 双向电刺激 + 光遗传 + 癫痫/AD 疾病建模。3Brain HD-MEA 下一代设计直接参考 (rating 5), Cellink 3D 打印 microlattice rating 5。
 > — Robin 8-08 精读
 ## Cross-reference
 - **Canonical synthesis:** this page (`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`)
 - **Vendor deep-read report:** `/home/ldw/workspace/Liu2026_NBME_shape_conformal_organoid.md`
 - **Wiki.js:** https://wiki.biokingdom.top/zh/literature/liu-2026-nbme-shape-conformal-organoid (Id 1692)
 - **NocoDB row:** 1 in **new table `Robin_Picked_Papers`** (table_id `mbjo0wb56qv1qly`)
 - **SeaFile PDF:** https://fb.biokingdom.top/f/6da50240729e41bdb369/?dl=1
 - **Vendor synthesis pages:** [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) (3Brain HD-MEA evidence anchor) + [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md) (Cellink + 3D bioprinting evidence anchor) + [`/commitments.md`](/commitments.md) `liu-2026-hd-mea-roadmap-implication` (vendor-R&D commitment) + [`/open-questions.md`](/open-questions.md) `liu-2026-rogers-lab-vs-3brain-relationship` (vendor relationship question)
 - **New NocoDB table:** `Robin_Picked_Papers` — created 2026-08-08 per Robin instruction; this paper is the first entry
@@ -0,0 +1,104 @@
 ---
 type: "Reference"
 title: "Miao 2025 — co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids (Cell v2)"
 description: "Deep-read synthesis of Miao Y et al. (2025) Cell v2 — single 3D EB co-induction of mesoderm+endoderm yields vHLPO with 7% ECs vs traditional 0%; FOXF1 mutation ACDMPV disease modeling; lung + gut organoid vascularization."
 tags: [literature, deep-read, lung-organoid, gut-organoid, vascularization, mesoderm-endoderm, celvivo-clinostar, 3brain-hd-mea-adjacent]
 ---
 # Miao 2025 — co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids (Cell v2)
 > Miao Y, Pek NM, Tan C et al. | **Cell** | 2025 | DOI: 10.1016/j.cell.2025.05.041 | PMID: 40592324
 > Wiki.js Id 1681 — https://wiki.biokingdom.top/zh/literature/miao-2025-cell-organoid-vascularization-v2
 > NocoDB row 93 in `Organoid_Literature` table
 > SeaFile PDF: https://fb.biokingdom.top/f/24704d54a95941449e2e/?dl=1 (7 figures)
 > Deep-read date: 2026-08-08 (v2); flywheel-sync `flywheel_index` completed 2026-08-08T09:16:07Z
 > Vendor deep-read report: `/home/ldw/workspace/Miao2025_Cell_v2.md`
 **Tags:** lung organoid | gut organoid | vascularization | co-differentiation mesoderm-endoderm | single 3D EB | BMP4 temporal | FOXF1 mutation | ACDMPV disease modeling | decellularized lung scaffold | scRNA-seq | organ-specific endothelium
 ---
 ## 0. Research background and core question
 **Background:** Conventional lung and gut organoid protocols differentiate one germ layer at a time — typically endoderm → lung/gut epithelium with mesoderm added separately. This produces organoids that lack **organotypic vasculature** (no endothelium, no pericytes, no in-vivo functional integration after transplantation). **This study** introduces a **single 3D embryoid body** protocol that **co-induces mesoderm + endoderm simultaneously**, yielding vHLPO (vascularized Human Lung Proximal Organoid) with 7% ECs vs traditional HLPO at 0%.
 **Core questions:**
 - Can a single 3D EB co-induction strategy produce organotypic vasculature in lung and gut organoids?
 - Does the co-differentiation approach yield organ-specific endothelium + mesenchyme, or generic mesoderm?
 - Does in-vivo transplantation of these vascularized organoids produce functional integration with host vasculature?
 - Can FOXF1 mutation (Alveolar Capillary Dysplasia with Misaligned Pulmonary Veins, ACDMPV) be modeled in vHLPO?
 ## 1. Key findings (4-paragraph three-segment format — 4-27 SOP standard)
 ### Key finding 1: Single 3D EB co-induction yields vHLPO with 7% ECs (vs traditional 0%)
 | What was done | What was found | What it means |
 | --- | --- | --- |
 | Day 0-3 BMP4 temporal signal in single 3D EB; Day 3-7 patterning; Day 7-21 organogenesis + vascular maturation | vHLPO 7% ECs (CD31+/CDH5+) vs traditional HLPO 0%; organ-specific endothelium + mesenchyme scRNA-seq confirms identity | **First lung organoid with reproducible organotypic vasculature** — solves the long-standing problem of avascular lung organoids that cannot survive transplantation. The co-induction approach is fundamentally different from adding endothelial cells to a pre-formed epithelium |
 ### Key finding 2: In vivo functional integration with host circulation
 | What was done | What was found | What it means |
 | --- | --- | --- |
 | vHLPO transplanted into immunodeficient mouse kidney capsule | Host vessels anastomose with vHLPO vasculature; human CD31+ vessels perfused with mouse blood; survival >4 weeks | vHLPO is not just in-vitro vascularization — it integrates with host circulation in vivo, opening the door to transplantable organoid therapies and disease modeling with systemic drug exposure |
 ### Key finding 3: FOXF1 mutation ACDMPV modeling — dual pathology validation
 | What was done | What was found | What it means |
 | --- | --- | --- |
 | Patient-derived iPSC with FOXF1 mutation differentiated via the same protocol | Dual pathology: alveolar type II cell defect + misaligned pulmonary veins + reduced vasculature | ACDMPV (a rare neonatal lethal lung disease) reproduces in vHLPO with both epithelial and vascular pathology — first patient-derived organoid model that captures the full ACDMPV phenotype |
 ### Key finding 4: Decellularized lung scaffold + vHLPO forms alveolar-capillary interface
 | What was done | What was found | What it means |
 | --- | --- | --- |
 | vHLPO seeded onto decellularized lung scaffolds and matured 14 days | Alveolar-like structures formed at the scaffold surface; partial alveolar-capillary interface | First proof-of-concept that vascularized organoids + decellularized scaffolds can reconstitute alveolar-capillary architecture — bridges 3D bioprinting (the scaffold) and organoid technology (the cellular component) |
 ## 2. Methodology
 | Step | Content | Key parameters |
 | --- | --- | --- |
 | 1. Co-differentiation | Single 3D EB simultaneously induces mesoderm + endoderm | Day 0-3 |
 | 2. BMP temporal | BMP4 temporal signal decides anterior-posterior axis fate | Day 0-3 |
 | 3. Patterning | Day 3-7 lineage commitment to lung/gut | — |
 | 4. Organogenesis + vascular maturation | Day 7-21 | — |
 | 5. scRNA-seq | Organ-specific endothelium + mesenchyme validation | — |
 | 6. In vivo transplant | Kidney capsule immunodeficient mouse | Survival >4 weeks |
 ## 3. Boundaries / Limitations
 - **BMP temporal signal validated only in this lung/gut model** — not yet confirmed in other organoid types (brain, liver, kidney). Generalizability unknown.
 - **FOXF1 mutation validated in only 1-2 patient iPSC lines** — small n for disease modeling.
 - **Decellularized lung scaffold + vHLPO ≠ complete functional alveolar-capillary interface** — alveolar-like structures formed but gas-exchange function not yet characterized.
 - **Static culture for organoid maturation** — same limitation as Sharma 2026; CelVivo ClinoStar low-shear rotating culture is a candidate route to extend maturation windows.
 ## 4. Product relevance (vendor cross-mapping)
 | Vendor / product | Rating | Evidence |
 | --- | ---: | --- |
 | **CelVivo ClinoStar** | **5** | Co-differentiation depends on 3D EB self-organization in low-shear rotating culture — ClinoStar is the canonical hardware for this protocol. The "static culture regression" boundary applies to the protocol; ClinoStar extends the maturation window |
 | **3Brain HD-MEA** | 4 | vHLPO contains developmentally-competent neural mesenchyme — neural electrophysiology readout would benefit from HD-MEA at the air-liquid interface |
 | **Live-cell metabolic analysis** | 4 | Vascularized vs non-vascularized metabolic flux comparison — Seahorse-class instruments quantify the metabolic benefit of vascularization |
 | **3D bioprinting (decellularized scaffold)** | 3 | Decellularized lung scaffold + vHLPO concept bridges 3D bioprinting (the scaffold) and organoid technology (the cellular component). Cellink BIO X could bioprint scaffolds with controlled porosity |
 | **Patient-derived organoid drug screening** | **5** | FOXF1 mutation ACDMPV modeling full pipeline — first patient-derived organoid model for ACDMPV. Same workflow applies to other rare disease FOXF1-class mutations |
 ## 5. Why this matters for Robin's portfolio
 - **Direct CelVivo ClinoStar ammunition:** the vHLPO protocol requires 3D EB co-induction — ClinoStar is the canonical hardware. This is the **strongest CelVivo ClinoStar product relevance rating (5)** in any of the 3 new flywheel-sync papers.
 - **Patient-derived organoid drug screening pipeline:** FOXF1 ACDMPV modeling is the kind of rare-disease story that opens pharma R&D conversations with Chinese pediatric hospitals and rare disease CDMOs.
 - **Cross-vendor co-marketing:** CelVivo ClinoStar (culture) + Cellink BIO X (decellularized scaffold printing) + 3Brain HD-MEA (functional readout) — three-vendor value chain.
 - **Sales ammunition:** "vHLPO 7% ECs vs traditional HLPO 0%" — vascularized lung organoid is a clinically-meaningful differentiator that no competing 2D / static culture can match.
 ## 6. Forward / 转发语 + 落款
 > Miao 2025 v2 是 lung + gut organoid 血管化首篇 — **single 3D EB 共分化 中-内胚层 → vHLPO 7% ECs vs 传统 HLPO 0%**, FOXF1 突变 ACDMPV 完整建模。CelVivo ClinoStar 是 canonical 硬件 (rating 5), 患者源类器官药筛完整管线建立。
 > — Robin 8-08 精读 v2
 ## Cross-reference
 - **Canonical synthesis:** this page (`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`)
 - **Vendor deep-read report:** `/home/ldw/workspace/Miao2025_Cell_v2.md`
 - **Wiki.js:** https://wiki.biokingdom.top/zh/literature/miao-2025-cell-organoid-vascularization-v2 (Id 1681)
 - **NocoDB row:** 93 in `Organoid_Literature` table
 - **SeaFile PDF:** https://fb.biokingdom.top/f/24704d54a95941449e2e/?dl=1
 - **Vendor synthesis pages:** [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) (CelVivo ClinoStar evidence anchor) + [`/sources/literature.md`](/sources/literature.md) (cross-agent index)
@@ -1,3 +1,10 @@
 ---
 type: "Reference"
 title: "Raji 2026 (hMOs + 3Brain HD-MEA) — 7-27 增补版 (跟 7-01 矩阵集成)"
 description: "Deep-read synthesis of Raji H, Bertoli F, Perez MJ, Lam A, Volpicelli-Daley LA, Deleidi M. 2026 Molecular Psychiatry (Nature 子刊, s41380-026-03667-4, DOI 10.1038/s41380-026-03667-4, IF 11) — human midbrain organoids (hMOs) with WNT modulation, dopaminergic neuron differentiation, bioreactor culture, and 3Brain HD-MEA electrophysiology for Parkinson's disease modeling. 7-01 实战范本 (page 1622) + 7-27 增补版 integrated with 3-paper 3Brain MEA matrix (Raji / Pali / Wei) and 4 product-line complementarity chain (CelVivo ClinoStar + Cellink BIO X + 3Brain HD-MEA + FemtoBiomed CellShot)."
 tags: [literature-deep-read, 3brain-hd-mea, midbrain-organoid, parkinson, dopaminergic-neuron, bioreactor, 2026-08-13]
 ---
 # Raji 2026 (hMOs + 3Brain HD-MEA) — 7-27 增补版 (跟 7-01 矩阵集成)
 > **7-01 精读 (page 1622) + 7-27 增补**: 这是 7-01 3 篇 3Brain MEA 矩阵的 Raji 那篇, 7-27 整合到 4 维提升 (跨 OpenWiki 互引 + 竞品对比 + 客户声音 + 我们产品实测 + 论文局限)
@@ -0,0 +1,101 @@
 ---
 type: "Reference"
 title: "Sharma 2026 — vascularized retinal organoid RGC survival and maturation (Cell Stem Cell)"
 description: "Deep-read synthesis of Sharma K et al. (2026) Cell Stem Cell — transiently vascularized human retinal organoids with RGC 18.2% vs ctrl-RO 1.21% at week 18, W31 ON/OFF/ON-OFF light responses, C3 endothelial monolayer integration strategy."
 tags: [literature, deep-read, retinal-organoid, vascularization, RGC, cell-stem-cell, 3brain-adjacent, celvivo-adjacent]
 ---
 # Sharma 2026 — vascularized retinal organoid RGC survival and maturation (Cell Stem Cell)
 > Sharma K, Habibey R, Ribeiro MM, Cui B, Siwicki RA, Striebel J, Pawlick JS, Zorn J, Utz L, Renner M, Picelli S, Holz FG, Ruiz de Almodóvar C, Cowan CS, Busskamp V. | **Cell Stem Cell** 33:253-271.e13 | 2026 | DOI: 10.1016/j.stem.2025.12.013 | PMID: 41529691
 > Wiki.js Id 1678 — http://10.10.10.254:3000/zh/literature/sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc
 > NocoDB row 700 in `Organoid_Literature` table
 > SeaFile PDF: https://fb.biokingdom.top/f/861202f029004d75b456/?dl=1 (7 figures: fig1 4d069beed4c445c59500 / fig2 c3fb945219954ae3907f / fig3 15e0f4ac28c34b369437 / fig4 47517582107e46569f8e / fig5 610aa8efdc7d4407a9d1 / fig6 91d711525355431a9c76 / fig7 35fbb156f3624a5fb15b)
 > Deep-read date: 2026-08-07; flywheel-sync `flywheel_index` completed 2026-08-08T03:19:30Z
 > Vendor deep-read report: `/home/ldw/workspace/retinal_organoid_deep_read_2026-08-07.md`
 **Tags:** retinal organoid | retinal ganglion cell (RGC) | vascularization | endothelial monolayer integration | ETV2.2 hiPSC | PDMS dual-chamber microfluidic | MEA electrophysiology | disease modeling | retinopathy of prematurity (ROP)
 ---
 ## 0. Research background and core question
 **Background:** Human retinal organoids (ROs) are 3D iPSC-derived tissues that recapitulate retinal histogenesis. They contain retinal ganglion cells (RGCs) but lack vasculature — this limits long-term RGC survival and functional maturation in vitro. **This study** introduces a transiently vascularized retinal organoid (vRO) via the C3 strategy (pre-differentiated endothelial cell monolayer integration) and characterizes RGC survival, maturation, and light-response fidelity.
 **Core questions:**
 - Can vascular-like networks be integrated into retinal organoids without disrupting retinal histogenesis?
 - Do vascularized ROs support higher RGC yield and longer functional maturation than non-vascularized controls?
 - Can vROs reproduce retinal light-response physiology (ON / OFF / ON-OFF responses) at week 31?
 ## 1. Key findings (4-paragraph three-segment format — 4-27 SOP standard)
 ### Key finding 1: C3 endothelial monolayer integration gives stable vascular-like network through W16
 | What was done | What was found | What it means |
 | --- | --- | --- |
 | Day 7 EBs onto pre-differentiated ETV2.2 hiPSC-derived endothelial cell monolayer; vRO + ctrl-RO cultured 31 weeks | 72.6% ± 5.4% EB PECAM1+ at week 3; 79.21% ± 6.1% vRO PECAM1+ at week 4; W16 PECAM1+ lumens 41.3% ± 4.19% perfusable by AF-598 dextran | The C3 strategy produces a vascular-like network that **perfuses** through week 16 — establishing a true vascularized retinal organoid model rather than a static endothelial cell co-culture |
 ### Key finding 2: W18 RGC yield 18.2% (vRO) vs 1.21% (ctrl-RO), p<0.001
 | What was done | What was found | What it means |
 | --- | --- | --- |
 | POU4F1+ RGC flow cytometry + scRNA-seq at W18 | 18.2% ± 4.31% (vRO) vs 1.21% ± 0.20% (ctrl-RO), p<0.001; RGC lineage maturation score 52% (vRO) vs 36% (ctrl-RO) | **15× RGC yield improvement** through vascularization — most ctrl-RO RGCs die by W18 without a vasculature to supply nutrients. RGC lineage maturation score also higher in vROs |
 ### Key finding 3: W31 ON/OFF/ON-OFF light responses with high fidelity
 | What was done | What was found | What it means |
 | --- | --- | --- |
 | MEA (Multi Channel Systems MEA2100-Lite, 60 channels, 32 kHz) recording of vRO spontaneous + evoked activity at W17-W31 | W17-W23 vRO spontaneous spiking + synchrony > ctrl-RO; W25 ctrl-RO silent, vRO still recordable; W31 ON/OFF/ON-OFF PSTH amplitudes 69/237/38 (vRO) vs 110/281/53 Hz (ctrl-RO); fidelity >90% (ON/ON-OFF) and 72%/53% (OFF) | vROs maintain activity beyond week 25 (when ctrl-ROs go silent) and reproduce retinal physiology ON / OFF / ON-OFF light-response classes — first retinal organoid model with sustained functional electrophysiology through week 31 |
 ### Key finding 4: ROP disease modeling via hypoxia + CoCl2 + VEGF
 | What was done | What was found | What it means |
 | --- | --- | --- |
 | W12 + 5d 4% O2 + 100 μM CoCl2 + 100 ng/mL VEGF | Neovascular phenotype observed (vessels + aberrant sprouting) | ROP model is reproducible in vROs — provides an in-vitro preclinical platform for retinopathy of prematurity drug screening |
 ## 2. Methodology
 | Step | Content | Key parameters |
 | --- | --- | --- |
 | 1. iPSC line | B7 hiPSC | — |
 | 2. Endothelial | ETV2.2 forward-programmed hiPSC (CD31+) | Pre-differentiation 7d before C3 integration |
 | 3. Integration | C3 strategy: d7 EB onto pre-differentiated EC monolayer | Microfluidic PDMS dual-chamber (5 μm high × 30 μm wide × 1,200 μm long microchannels) |
 | 4. Culture | vRO + ctrl-RO 31 weeks | Static culture (paper notes limitation — see §Boundaries) |
 | 5. MEA | Multi Channel Systems MEA2100-Lite | 60 channels, 32 kHz |
 | 6. Opsin | POU4F1-f-ChRimson-EYFP (optogenetic) + endogenous photoreceptors (W31) | — |
 ## 3. Boundaries / Limitations
 - **Vascular-like network regresses in static culture** — not stable long-term vasculature (a candidate route to extend network stability is low-shear rotating culture, e.g. CelVivo ClinoStar)
 - **scRNA-seq at W18 missed endothelial cluster** — protein-level PECAM1 still visible but transcriptomics underrepresents the vascular compartment
 - **POU4F1 is not RGC-exclusive** — needs orthogonal evidence (e.g. BRN3A, ISL1 co-staining)
 - **60-channel standard MEA** — not HD coverage (3Brain HD-MEA at 4096 electrodes would offer 10-50× spatial resolution for the same recording)
 - **5-day hypoxia + CoCl2 + VEGF model is acute stimulus**, not full ROP pathology
 ## 4. Product relevance (vendor cross-mapping)
 | Vendor / product | Rating | Evidence |
 | --- | ---: | --- |
 | **3Brain HD-MEA** | 4 | Paper uses 60-channel MEA2100-Lite (Multi Channel Systems); 3Brain HD-MEA is same-generation HD technology (4096 electrodes vs 60). Technical route is transferable — Sharma's W31 light-response recording paradigm is the kind of long-duration, multi-class (ON/OFF/ON-OFF) recording where HD spatial resolution matters most |
 | **CelVivo ClinoStar** | 3 | Paper notes vascular-like network regresses in static culture — ClinoStar low-shear rotating culture is the candidate route to extend network stability beyond W16 (vascular network regression is the biggest limitation in the paper) |
 ## 5. Why this matters for Robin's portfolio
 - **Application-domain entry:** retinal organoid is one of the 4 application domains (3D cell culture / 3D bioprinting / neuroscience in vitro / organoid workflows). Robin has only 1 prior retinal deep-read (`Schwab 2025 bioRxiv` 3D-printed bioreactor retinal organoids, 2026-06-28). Sharma 2026 is the **first peer-reviewed retinal organoid paper with vascularization** in Robin's deep-read corpus.
 - **HD-MEA cross-sell:** the paper uses 60-channel MEA, not 3Brain HD-MEA — this is a **vendor-adjacent signal** for "if you want to do Sharma-style retinal recording at higher spatial resolution, use 3Brain Accura-3D + 4096 electrodes".
 - **CelVivo ClinoStar cross-sell:** the paper's #1 limitation (vascular regression in static culture) is exactly the failure mode ClinoStar low-shear rotating culture was designed to fix — strong co-marketing story.
 - **Sales ammunition:** "vRO W18 RGC 18.2% vs ctrl-RO 1.21%" — 15× RGC yield improvement is a clear vendor-adjacent differentiator.
 ## 6. Forward / 转发语 + 落款
 > Sharma 2026 是 retinal organoid 血管化首篇 — **W18 RGC 18.2% vs ctrl-RO 1.21% (15×)**, W31 ON/OFF/ON-OFF 光响应保真度 >90%。技术栈 (60-channel MCS MEA2100-Lite + 静态培养) 是 3Brain HD-MEA + CelVivo ClinoStar 的天然升级路径 — retinal organoid 是 Robin portfolio 里缺位的赛道。
 > — Robin 8-08 精读
 ## Cross-reference
 - **Canonical synthesis:** this page (`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`)
 - **Vendor deep-read report:** `/home/ldw/workspace/retinal_organoid_deep_read_2026-08-07.md`
 - **Wiki.js:** http://10.10.10.254:3000/zh/literature/sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc (Id 1678)
 - **NocoDB row:** 700 in `Organoid_Literature` table
 - **SeaFile PDF:** https://fb.biokingdom.top/f/861202f029004d75b456/?dl=1
 - **Vendor synthesis pages:** [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) (3Brain HD-MEA evidence anchor) + [`/sources/literature.md`](/sources/literature.md) (cross-agent index)
@@ -1,3 +1,10 @@
 ---
 type: "Reference"
 title: "3D 打印缓释 HCTZ 片: 跟 Cellink BIO X 挤出打印 (Tasevska 2025 EJPS)"
 description: "Deep-read synthesis of Tasevska T et al. 2025 European Journal of Pharmaceutical Sciences 206:106998 (DOI 10.1016/j.ejps.2024.106998, 精读 2026-07-27) — first systematic SSE semi-solid extrusion vs DLP digital-light-processing comparison for sustained-release HCTZ (hydrochlorothiazide) tablets, with focus on SSE matching Cellink BIO X extrusion principle. Supports Robin's 3D-printed personalized-dose / sustained-release positioning and SSE extruder cross-sell narrative for Cellink BIO X accounts."
 tags: [literature-deep-read, cellink-bio-x, 3d-printing, HCTZ, sustained-release, SSE, DLP, 2026-08-13]
 ---
 # 3D 打印缓释 HCTZ 片: 跟 Cellink BIO X 挤出打印 (Tasevska 2025 EJPS)
 > Tasevska T, Adamov I, Geskovski N, et al. | **European Journal of Pharmaceutical Sciences** 206 (2025) 106998 | DOI: 10.1016/j.ejps.2024.106998 | 精读 2026-07-27
@@ -1,91 +1,234 @@
-# Literature Deep-Reads — 跨 agent 精读索引
+---
 type: "Reference"
 title: "Literature Deep-Reads — cross-agent deep-read index"
 description: "Cross-agent index of Robin's literature deep-reads across the 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed) and adjacent application domains (organoid IRB / ethics, vascularized organoids, microfluidic / organ-on-chip). Backed by the Obsidian vault 04-Literature/Deep-Reads/ and the flywheel-sync pipeline; synthesis pages are linked per paper."
 tags: [literature, deep-read, flywheel, celvivo, 3brain, cellink, femtobiomed]
 ---
-> 数据源: Obsidian vault `04-Literature/Deep-Reads/<vendor>/<DOI>.md` (git-repo connector 自动同步)
+# Literature Deep-Reads — cross-agent deep-read index
 > 用途: MiniMax code / Hermes 跨 agent 检索 "Robin 最近精读了什么文献"
 > 更新: OpenWiki cron 每天 02:00 自动扫 vault mtime, 增量更新本文件
-## 最近 30 天精读 (按 mtime 倒序)
+> Source: Obsidian vault `04-Literature/Deep-Reads/<vendor>/<DOI>.md` (git-repo connector auto-sync) + flywheel-sync `~/.hermes/data_sources/literature_flywheel.jsonl` for pipeline status.
 > Purpose: allow MiniMax code / Hermes cross-agent retrieval of "what has Robin recently deep-read".
 > Update: OpenWiki cron runs at 02:00 daily; today's flywheel-sync (2026-08-08) has completed `flywheel_index` on 3 papers (Sharma 2026 Cell Stem Cell, Miao 2025 Cell v2, Liu 2026 Nat Biomed Eng) — see the new entries below.
 ## Last 30 days of deep reads (mtime descending)
 ### 2026-08-16 (Quintard 2024 + Guo 2026 — 2 papers on the same day)
 | DOI | Vendor | Application | Title (short) | Vault path |
 | --- | --- | --- | --- | --- |
 | `10.1038/s41467-024-45710-4` | CelVivo (ClinoStar rating 3 upstream) + Mimetas OrganoPlate (rating 4 direct) + Emulate Organ-Chip (rating 3) | Microfluidic platform for vascularized organoids | Quintard C et al. (2024) A microfluidic platform integrating functional vascularized organoids-on-chip (Nat Commun; 10 通道并行微流控芯片 + U 型捕获位 + hiPSC-BVO 30 天功能性灌注培养 + 跨类器官验证 [间充质球体 / BVO / 胰岛球体 / 肺类器官]; 血管层级化 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管, 壁剪切 27-2000 s⁻¹ 完美匹配人体毛细血管生理范围 50-1900 s⁻¹) — Wiki.js IDs 1719/1720/1722, NocoDB Id 3297; 4-commit LDR cycle 2026-08-16 (`0fc8db24` → `290e9635` → `24c713de` → `4073abf4`); last commit deleted the 3Brain reference per the SOP "硬门槛合规修正" cleanup rule | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` |
 | `10.3389/fcell.2026.1721946` | CelVivo (ClinoStar rating 4 clinical-translation IRB) + Mimetas OrganoPlate (rating 4 co-culture ethics) + Emulate Organ-Chip (rating 3) | Organoid research IRB / ethics systematic review | Guo Z & Zhang N (2026) Ethical review key considerations for organoid applications in biomedical research—a systematic review (Front Cell Dev Biol; 嘉兴市第一医院 + 嘉兴大学医学院视角; 类器官研究 IRB / 伦理审查 7 大强制要点系统综述 [样本来源/知情同意/数据隐私/共培养主体性/3R 动物福利/跨境监管/长期保存与终止使用] + 5 国对照 [中国《人类遗传资源管理条例》+《涉及人的生命科学和医学研究伦理审查办法》2023 / 美国 HIPAA + Common Rule + NIH GDS / 欧盟 GDPR + Clinical Trials Regulation 536/2014 / 日本 / 韩国]) — Wiki.js ID 1724, NocoDB Id 3298; 3-commit LDR cycle 2026-08-16 (`2e6f5989` → `00f824f2` → `a4fa5a32`); Robin translated the paper into a customer-facing IRB application checklist template at `templates/类器官IRB申请清单.md` v1.0 (180 lines; 7 mandatory points + 5 customer Q&A + China vs International flow + 10 attachments + 7 citations) | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` |
 ### 2026-08-09
 | DOI | Vendor | Application | Title (short) | Vault path |
 | --- | --- | --- | --- | --- |
 | `10.7150/thno.90492` | Microfluidic chip system + 类器官培养试剂 + 高内涵成像 + 单细胞与空间组学 (4 类共性硬件) | Organoid-on-Chip 综述 / 类器官 + 器官芯片协同平台 / 血管化、疾病建模、精准医学 | Wang H, Ning X, Zhao F, Zhao H, Li D. (2024) Human organoids-on-chips for biomedical research and applications (Theranostics 14(2):788-818, PMID 38169573; 7 图覆盖 7 大主题板块: OOCs/HOs/OrgOCs 架构 + 器官发育/血管化/免疫/器官通讯/疾病建模/精准医学; PMCID PMC10758054) — NocoDB row 3295 in `Organoid_Literature`, Wiki.js ID 1700 (v2 - grp:3 ghost page 累加) | `04-Literature/Deep-Reads/wang2024-org-on-chip.md` |
 ### 2026-08-08 (4 papers — flywheel-sync completed today)
 | DOI | Vendor | Application | Title (short) | Vault path |
 | --- | --- | --- | --- | --- |
 | `10.1038/s41551-026-01620-y` | 3Brain (HD-MEA) + Cellink (microlattice) | Neural organoid e-phys drug screen | Liu N et al. (2026) Shape-conformal porous frameworks for full coverage of neural organoids and high-resolution electrophysiology (Nat Biomed Eng, Rogers Lab; >90% surface coverage vs 5-15% MEA; 3000-8000 channels per organoid; weeks-long stable recording; epilepsy/AD modeling) — first entry in NocoDB table `Robin_Picked_Papers` | `Liu2026_NBME_shape_conformal_organoid.md` (in `/home/ldw/workspace/`) |
 | `10.1016/j.cell.2025.05.041` | CelVivo (ClinoStar) + 3Brain (HD-MEA adjacent) | Lung/gut organoid vascularization | Miao Y et al. (2025) Co-development of Mesoderm and Endoderm Enables Organotypic Vascularization in Lung and Gut Organoids (Cell; vHLPO 7% ECs vs traditional HLPO 0%; single 3D EB co-induction of mesoderm+endoderm; FOXF1 mutation ACDMPV modeling) — NocoDB row 93 in `Organoid_Literature` | `Miao2025_Cell_v2.md` (in `/home/ldw/workspace/`) |
 | `10.1016/j.stem.2025.12.013` | 3Brain (HD-MEA, adjacent) + CelVivo (ClinoStar, adjacent) | Retinal ganglion cell / vascularized retinal organoid | Sharma K et al. (2026) Retinal ganglion cell survival and functional maturation in transiently vascularized human retinal organoids (Cell Stem Cell 33:253-271.e13, PMID 41529691; C3 endothelial integration strategy; W18 POU4F1+ RGC 18.2% vs 1.21% p<0.001; W31 ON/OFF/ON-OFF light responses >90%/72%/53% fidelity) — NocoDB row 700 in `Organoid_Literature` | `Retina-StemCell/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc.md` (planned) |
 | `10.3389/fbioe.2026.1854988` | CelVivo (ClinoStar adjacent) + Cellink (BIO X adjacent) + FemtoBiomed (CellShot adjacent) | Microbioreactor design for eukaryotic cell-based biomedical applications | Rosero G et al. (2026) Microbioreactor design for eukaryotic cell-based biomedical applications (Front Bioeng Biotechnol, Mini Review; 6x productivity vs T-flask; organoid size 140% vs static control; 4 applications: CAR-T / mAb / iPSC / organoid) — NocoDB: `Robin_Picked_Papers` (PMID 42516424, Wiki.js ID 1696) | `Microbioreactor_2026_Rosero_FrontBioeng.md` (in `/home/ldw/workspace/`) |
 ### 2026-08-08 (Fernandez Vallone 2026 — untracked, deep-read commit `6c16dc05` + `d7df3830`)
 | DOI | Vendor | Application | Title (short) | Vault path |
 | --- | --- | --- | --- | --- |
 | `10.3390/cells15110963` | CelVivo (ClinoStar adjacent) + 3Brain (HD-MEA adjacent) | hiPSC brain organoid Thyroid Hormone System Disrupting Chemicals (THSDC) platform | Fernandez Vallone V et al. (2026) Comparative Evaluation of hiPSC-Derived Brain Organoids as Platforms for Assessing Thyroid Hormone System Disrupting Chemicals (Cells 15:963, PMID 42274556; COs vs NSCOs; LC-MS/MS T3代谢; qRT-PCR HR/KLF9/DIO3/SEMA3C; HCA; THSDC = iopanoic acid + silychristin) — NocoDB row 3263 in `Robin_Picked_Papers`, Wiki.js Id 1698, v2 (5 张真图 + 双 H1) | `obsidian-vault/04-Literature/Deep-Reads/Cells/fernandez-vallone-2026-thsdc-brain-organoids.md` |
 ### 2026-08-06 (Parfitt 2024 Nat Commun — untracked deep-read, hiPSC midbrain organoid DJ1 LOF PD model)
 | DOI | Vendor | Application | Title (short) | Vault path |
 | --- | --- | --- | --- | --- |
 | `10.1038/s41467-024-44732-2` | CelVivo (ClinoStar adjacent) + 3Brain (HD-MEA adjacent) | DJ1 LOF / midbrain organoid / Parkinson disease model | Parfitt GM et al. (2024) DJ1 缺失破坏星形胶质溶酶体蛋白降解，引发中脑类器官蛋白稳态崩溃（Nat Commun 15:1071, PMID 38200091; DJ1 KO + L166P 突变 iPSC hMIDOs; 星形胶质 α-synuclein 旁分泌毒性放大 DA 神经元死亡) | `04-Literature/Deep-Reads/Brain/2026-08-06_Parfitt_GM_et_al_NatCommun_2024_DJ1_LOF_midbrain_organoid_PD.md` |
 ### 2026-07-29
 | DOI | Vendor | Application | Title (short) | Vault path |
 | --- | --- | --- | --- | --- |
 | `10.1186_s40164-026-00743-x` | (no vendor, review) | Whole-organoid landscape | Organoids for disease modeling and treatment: state-of-the-art (Exp Hematol Oncol 2026, PMID 41545895, 190 clinical trials + 4 bottlenecks) | `Organoid/2026-07-29_Organoids_disease_modeling_treatment_2026_review.md` |
 ### 2026-07-28
-| DOI | Vendor | 类器官 | 标题 | 路径 |
+
-|---|---|---|---|---|
+| DOI | Vendor | Application | Title (short) | Vault path |
-| `10.1080_17460751.2025.2572177` | Ronawk Bio-Block (KB 0 命中) | MSC / 脂肪源 | Comparison of 3D culture systems on MSC longevity, regenerative potential, and secretome production | `RegenMed/2026-07-28_Hodge_2025_RegenMed_MSC_3D_Bio-Block.md` |
+| --- | --- | --- | --- | --- |
-| `10.3389/fvets.2025.1500267` | (无 vendor) | 犬脂肪 MSC 3D 球体 | Lee E et al. (2025) Enhanced immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells in 3D culture (Front Vet Sci 12:1500267, ULA 板 48h, 3D CM 显著压低 LPS-DH82 M1 p<0.0001) | `Other/2026-07-28_Lee_2025_FrontVetSci_canine_MSC_3D_spheroid.md` |
+| `10.1080_17460751.2025.2572177` | Ronawk Bio-Block (KB 0 hit) | MSC / adipose source | Comparison of 3D culture systems on MSC longevity, regenerative potential, and secretome production (Hodge 2025) | `RegenMed/2026-07-28_Hodge_2025_RegenMed_MSC_3D_Bio-Block.md` |
 | `10.3389/fvets.2025.1500267` | (no vendor) | Canine adipose MSC 3D spheroid | Lee E et al. (2025) Enhanced immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells in 3D culture (Front Vet Sci 12:1500267, ULA plate 48h, 3D CM significantly suppresses LPS-DH82 M1 p<0.0001) | `Other/2026-07-28_Lee_2025_FrontVetSci_canine_MSC_3D_spheroid.md` |
 ### 2026-07-17
-| DOI | Vendor | 类器官 | 标题 | 路径 |
+
-|---|---|---|---|---|
+| DOI / slug | Vendor | Application | Title (short) | Vault path |
-| `260528_appnote` | CelVivo | 通用 | Influence of shear stress on long-term 3D construct performance: Comparison of orbital shaker and ClinoStar system (vs 竞品杀手文档) | `Celvivo/260528_CS_versus_OS_appnote_2026-07-17.md` |
+| --- | --- | --- | --- | --- |
-| `111_appnote` | CelVivo | 球体量化 | Planimetry measurements of spheroids in a ClinoReactor using FIJI - Application Note | `Celvivo/111_Planimetry_ClinoReactor_FIJI_2026-07-17.md` |
+| `260528_appnote` | CelVivo | Generic | Influence of shear stress on long-term 3D construct performance: Comparison of orbital shaker and ClinoStar system (vs-competitor killer document) | `Celvivo/260528_CS_versus_OS_appnote_2026-07-17.md` |
-| `Raji_2026_hMOs` | 3Brain | 多巴胺 / 中脑类器官 | Engineering functional ventral midbrain dopaminergic neurons in human organoids (hMOs + 3Brain HD-MEA) | `3Brain/Raji_2026_hMOs_dopaminergic_3Brain_MEA_2026-07-27.md` |
+| `111_appnote` | CelVivo | Spheroid quantification | Planimetry measurements of spheroids in a ClinoReactor using FIJI — Application Note | `Celvivo/111_Planimetry_ClinoReactor_FIJI_2026-07-17.md` |
-| `Tasevska_2025_HCTZ` | Cellink | 缓释药片 | 3D printed extended-release hydrochlorothiazide tablets (SSE 工艺, BIO X 适用) | `Cellink/Tasevska_2025_HCTZ_3D_printed_extended_release_2026-07-27.md` |
+| `Raji_2026_hMOs` | 3Brain | Dopaminergic / midbrain organoid | Engineering functional ventral midbrain dopaminergic neurons in human organoids (hMOs + 3Brain HD-MEA) | `3Brain/Raji_2026_hMOs_dopaminergic_3Brain_MEA_2026-07-27.md` |
 | `Tasevska_2025_HCTZ` | Cellink | Extended-release tablet | 3D printed extended-release hydrochlorothiazide tablets (SSE process, BIO X compatible) | `Cellink/Tasevska_2025_HCTZ_3D_printed_extended_release_2026-07-27.md` |
 ### 2026-07-05
-| DOI | Vendor | 类器官 | 标题 | 路径 |
+
-|---|---|---|---|---|
+| DOI | Vendor | Application | Title (short) | Vault path |
 | --- | --- | --- | --- | --- |
 | `10.1002_btpr.2528` | CelVivo | Spheroid dissociation | Novel fluid shear-based dissociation device for improved single cell dissociation of spheroids | `Celvivo/10.1002_btpr.2528.md` |
-### 2026-06-25 (2 篇)
+### 2026-06-25 (2 papers)
 | DOI | Vendor | 类器官 | 标题 | 路径 |
 |---|---|---|---|---|
 | `10.1016_j.stemcr.2025.102646` (v1) | CelVivo | 通用 | High-throughput human microfluidic organoid-on-a-chip platform | `Celvivo/10.1016_j.stemcr.2025.102646.md` |
 | `10.1016_j.stemcr.2025.102646_v2` | CelVivo | 通用 | 同上 v2 (重写) | `Celvivo/10.1016_j.stemcr.2025.102646_v2.md` |
-### 2026-06-24 (2 篇)
+| DOI | Vendor | Application | Title (short) | Vault path |
-| DOI | Vendor | 类器官 | 标题 | 路径 |
+| --- | --- | --- | --- | --- |
-|---|---|---|---|---|
+| `10.1016_j.stemcr.2025.102646` (v1) | CelVivo | Generic | High-throughput human microfluidic organoid-on-a-chip platform | `Celvivo/10.1016_j.stemcr.2025.102646.md` |
-| `10.1021_acsomega.5c02682` | 3Brain | 皮肤 | Developing tumor microenvironment in rotating human melanoma cell culture | `3Brain/10.1021_acsomega.5c02682.md` |
+| `10.1016_j.stemcr.2025.102646_v2` | CelVivo | Generic | Same as v1, rewritten | `Celvivo/10.1016_j.stemcr.2025.102646_v2.md` |
 | `10.1016_j.xpro.2025.103923` | CelVivo | 肺 | Protocol for the Establishment and Characterization of Lung Tumoroids | `Celvivo/10.1016_j.xpro.2025.103923.md` |
-### 2026-06-23 (2 篇)
+### 2026-06-24 (2 papers)
 | DOI | Vendor | 类器官 | 标题 | 路径 |
 |---|---|---|---|---|
 | `10.1002_jbm4.10792` | CelVivo | 通用 | High-throughput microfluidic organoid-on-a-chip (v2-munir2023) | `Celvivo/10.1002_jbm4.10792-v2-munir2023.md` |
 | `10.3390_cells11203216` | CelVivo | 肝 NAFLD | Mapping Proteome and Lipidome Changes in Early-Onset NAFLD | `Celvivo/10.3390_cells11203216.md` |
-## 按 Vendor 统计 (mtime 2026-06-16 → 2026-07-28)
+| DOI | Vendor | Application | Title (short) | Vault path |
 | --- | --- | --- | --- | --- |
 | `10.1021_acsomega.5c02682` | 3Brain | Skin | Developing tumor microenvironment in rotating human melanoma cell culture | `3Brain/10.1021_acsomega.5c02682.md` |
 | `10.1016_j.xpro.2025.103923` | CelVivo | Lung | Protocol for the Establishment and Characterization of Lung Tumoroids | `Celvivo/10.1016_j.xpro.2025.103923.md` |
-| Vendor | 30 天精读数 | 最近一篇 |
+### 2026-06-23 (2 papers)
 |---|---|---|
 | **CelVivo** | 5 篇 | 2026-07-05 |
 | **3Brain** | 1 篇 | 2026-06-24 |
 | **Cellink** | 1 篇 | 2026-07-27 |
 | **Ronawk Bio-Block** (KB 0 命中) | 1 篇 | 2026-07-28 |
-## 4 周 MSC 长期培养关键词命中 (累计)
+| DOI | Vendor | Application | Title (short) | Vault path |
 | --- | --- | --- | --- | --- |
 | `10.1002_jbm4.10792` | CelVivo | Generic | High-throughput microfluidic organoid-on-a-chip (v2-munir2023) | `Celvivo/10.1002_jbm4.10792-v2-munir2023.md` |
 | `10.3390_cells11203216` | CelVivo | Liver NAFLD | Mapping Proteome and Lipidome Changes in Early-Onset NAFLD | `Celvivo/10.3390_cells11203216.md` |
- `Bio-Block Ronawk 3D culture mesenchymal` (2026-07-28 入库, **未 KB 验证**; 4 周时窗 vs 2D/球体/Matrigel 平台对比)
+## Vendor statistics (mtime 2026-06-16 → 2026-08-08)
 - `Hodge Mellott Bio-Block 3D culture` (2026-07-28 入库, **未 KB 验证**; 同上 Ronawk 团队 USC Kansas)
-## ClinoReactor 关键词命中 (累计)
+| Vendor | 30-day deep-read count | Most recent | New this run (2026-08-08) |
 | --- | ---: | --- | --- |
 | **CelVivo** | 5 | 2026-07-05 | — |
 | **3Brain** | 1 (+ Liu 2026 + Sharma 2026 as adjacent) | 2026-06-24 (canonical) / 2026-08-08 (Liu / Sharma as HD-MEA-adjacent) | Liu 2026 (HD-MEA rating 5), Sharma 2026 (HD-MEA rating 4) |
 | **Cellink** | 1 | 2026-07-27 | — |
 | **CelVivo + 3Brain cross** | 1 | 2026-07-27 | Miao 2025 v2 (CelVivo ClinoStar rating 5, HD-MEA rating 4) |
 | **Cellink + 3Brain cross** | 0 | — | Liu 2026 (3D bioprinting microlattice rating 5) |
 | **Across all 4 vendors** (Microbioreactor review) | 1 | 2026-08-08 | Rosero 2026 Front Bioeng Biotechnol (CAR-T / mAb / iPSC / organoid — 4 applications) |
 | **Brain organoid + THSDC** (NAMs adjacent) | 1 | 2026-08-08 | Fernandez Vallone 2026 Cells (hiPSC brain organoid THSDC platform, v2 5 张真图 + 双 H1; Wiki.js Id 1698) |
 | **Brain organoid + PD model** | 1 | 2026-08-06 | Parfitt 2024 Nat Commun (DJ1 LOF midbrain organoid PD model, untracked) |
 | **Ronawk Bio-Block** (KB 0 hit) | 1 | 2026-07-28 | — |
- `Planimetry measurements of spheroids in a ClinoReactor using FIJI` (2026-04-01 入库, **未精读**)
+## 4-week MSC long-term-culture keyword hits (cumulative)
-## 跟 OpenWiki 其他源的关系
+- `Bio-Block Ronawk 3D culture mesenchymal` (2026-07-28 added, **not KB-validated**; 4-week window vs 2D/spheroid/Matrigel platform comparison)
 - `Hodge Mellott Bio-Block 3D culture` (2026-07-28 added, **not KB-validated**; same Ronawk team USC Kansas)
-| 源 | 看什么 |
+## ClinoReactor keyword hits (cumulative)
 |---|---|
 | **本文件** (literature.md) | 精读笔记 (本文件) |
 | `sources/hackernews.md` | 外部公开讨论 |
 | `sources/git-repo.md` | vault 整体结构 |
 | `commitments.md` | Robin 任务承诺 |
 | `themes.md` | 跨源主题综合 |
-## 触发查询示例 (MiniMax code 用)
+- `Planimetry measurements of spheroids in a ClinoReactor using FIJI` (2026-04-01 added, **not yet deep-read**)
- "Robin 最近精读了哪些 CelVivo 文献" → 读本文件 CelVivo 段
+## Flywheel-sync pipeline (today, 2026-08-08)
 - "ClinoReactor 相关最新研究" → 读本文件 ClinoReactor 段 + ClinoReactor 关键词命中
 - "近一周有什么新文献" → 读本文件 "最近 7 天" 段
-## 维护方式
+The `~/.hermes/data_sources/literature_flywheel.jsonl` records each paper's 8-step pipeline status (`type_judgment` → `pdf_full_text` → `image_extract` → `ollama_audit` → `seafile_upload` → `report_written` → `wiki_published` → `nocodb_patched` → `obsidian_pushed` → `openwiki_pushed` → `flywheel_index`). Today's `flywheel_index` completions:
- **手动触发**: 通知 Robin "更新 literature 索引"
+| Paper | NocoDB destination | Wiki.js URL | Wiki Id |
- **自动**: OpenWiki cron 每天 02:00 跑 git-repo connector, 写本文件
+| --- | --- | --- | ---: |
- **路径**: `~/.openwiki/wiki/sources/literature.md` (同步推 Gitea)
+| Liu 2026 Nat Biomed Eng | **new table `Robin_Picked_Papers`** (created 2026-08-08, table_id `mbjo0wb56qv1qly`, row_id 1) | https://wiki.biokingdom.top/zh/literature/liu-2026-nbme-shape-conformal-organoid | 1692 |
-### 2026-07-28
+| Miao 2025 Cell v2 | `Organoid_Literature` table (row 93) | https://wiki.biokingdom.top/zh/literature/miao-2025-cell-organoid-vascularization-v2 | 1681 |
-| DOI | Vendor | 类器官 | 标题 | 路径 |
+| Sharma 2026 Cell Stem Cell | `Organoid_Literature` table (row 700) | http://10.10.10.254:3000/zh/literature/sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc | 1678 |
-|---|---|---|---|---|
+
-| `10.1080_17460751.2025.2572177` | Ronawk Bio-Block (KB 0 命中) | MSC / 脂肪源 | Comparison of 3D culture systems on MSC longevity (Hodge 2025) | `RegenMed/10.1080_17460751.2025.2572177.md` |
+The `Robin_Picked_Papers` table is **new as of today** — created per Robin's 2026-08-08 instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage. Liu 2026 is the first entry. This is **separate** from the existing `Organoid_Literature` table (which Miao 2025 v2 + Sharma 2026 landed in).
-| `10.1186_s13287-018-1085-9` | KB: CelVivo+Cellink 命中 | MSC / 3D 漂浮 | Type I collagen deposition ameliorates YAP/TAZ (Komatsu 2018) | `Cellink/10.1186_s13287-018-1085-9.md` |
+
-| `10.3389_fvets.2025.1500267` | KB: 0 命中 | MSC 犬源 | Enhanced immunomodulation of canine MSC 3D (Lee 2025) | `Other/10.3389_fvets.2025.1500267.md` |
+## Cross-reference with other OpenWiki sources
-| `10.1186_s13287-020-1566-5` | KB: CelVivo+Cellink 命中 | MSC / PEMF / 软骨 | PEMF potentiate MSC paracrine cartilage (Parate 2020) | `Other/10.1186_s13287-020-1566-5.md` |
+
 | Source | Look here for |
 | --- | --- |
 | **This page** (`/sources/literature.md`) | Deep-read notes index + flywheel-sync pipeline status |
 | [`/sources/hackernews.md`](/sources/hackernews.md) | External public discussion |
 | [`/sources/git-repo.md`](/sources/git-repo.md) | Vault overall structure |
 | [`/commitments.md`](/commitments.md) | Robin's task commitments |
 | [`/themes.md`](/themes.md) | Cross-source synthesis |
 | [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) | CelVivo + 3Brain vendor synthesis (with HD-MEA + ClinoStar evidence anchors for Liu 2026 / Miao 2025 v2 / Sharma 2026) |
 | [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md) | Cellink + 3D bioprinting synthesis (with Liu 2026 microlattice evidence anchor) |
 ## Trigger queries (for MiniMax code)
 - "What CelVivo papers has Robin deep-read recently?" → read this page's CelVivo rows + `/themes/01-organoid-equipment.md` CelVivo section
 - "Latest ClinoReactor research" → read this page's ClinoReactor keyword hits + Miao 2025 v2 (vascularization cross-reference)
 - "What new papers in the past week?" → read this page's "Last 30 days" section, top 3 rows
 - "Liu 2026 shape-conformal neural organoid HD-MEA — what is it?" → [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md)
 - "Fernandez Vallone 2026 hiPSC brain organoid THSDC — what is it?" → deep-read at `obsidian-vault/04-Literature/Deep-Reads/Cells/fernandez-vallone-2026-thsdc-brain-organoids.md` (Wiki.js Id 1698, NocoDB row 3263, v2 with 5 张真图 + 双 H1)
 - "Parfitt 2024 DJ1 LOF midbrain organoid PD model — what is it?" → deep-read at `04-Literature/Deep-Reads/Brain/2026-08-06_Parfitt_GM_et_al_NatCommun_2024_DJ1_LOF_midbrain_organoid_PD.md` (Nat Commun 15:1071, PMID 38200091)
 ## 8-07 vault mtime additions (working-tree deep-reads — not yet on `main`)
 > Observed in the 2026-08-08 git-repo connector pull as **untracked files in the working tree**. These are working-tree deep-reads that the next LDR commits will fold onto `main`.
 | Path | Status | Note |
 | --- | --- | --- |
 | `Liu2026_NBME_shape_conformal_organoid.md` | untracked @ `/home/ldw/workspace/` | canonical 2026-08-08 paper; v2-v11 已经 commit `1614ccf9` to `main` |
 | `Miao2025_Cell_v2.md` | untracked @ `/home/ldw/workspace/` | canonical 2026-08-08 paper; v2 已 commit `1c05eee7` to `main` |
 | `Miao2025_Cell_vascularized_organoid.md` | untracked @ `/home/ldw/workspace/` | 出处未明 working copy |
 | `Microbioreactor_2026_Rosero_FrontBioeng.md` | untracked @ `/home/ldw/workspace/` | 2026-08-08 论文 working copy; v2 with SeaFile links 已 commit `65fef021` to `main` |
 | `04-Literature/Deep-Reads/Brain/2026-08-06_Parfitt_GM_et_al_NatCommun_2024_DJ1_LOF_midbrain_organoid_PD.md` | untracked (2026-08-06) | DJ1 LOF midbrain organoid PD model (Parfitt 2024 Nat Commun) |
 | `obsidian-vault/04-Literature/Deep-Reads/Cells/fernandez-vallone-2026-thsdc-brain-organoids.md` | untracked (2026-08-08) | Fernandez Vallone 2026 Cells hiPSC 脑类器官 THSDC (commits `6c16dc05` + `d7df3830`) |
 | `retinal_organoid_deep_read_2026-08-07.md` | untracked @ `/home/ldw/workspace/` | Sharma 2026 working copy |
 | `rustdesk-selfhosted-2026-08-05.md` | untracked @ `/home/ldw/workspace/obsidian-vault/` | 独立的 RustDesk 自建部署笔记 (related to `/sources/rustdesk-sop.md`) |
 | `dify精读进度-20260805.md` | untracked @ `/home/ldw/workspace/` | Dify 文档精读进度追踪 |
 | `literature_deepread_v6.py` + `__pycache__/` | untracked @ `/home/ldw/workspace/` | LDR pipeline v6 脚本 (脚本源) |
 | `文悦精读流程线.yml` v1-v5-clean | untracked @ `/home/ldw/workspace/` | Dify 精读流程线 workflow YAML (5 版迭代) |
 ## 8-07 _known_associations.md 接续
 > 2026-08-07 added Obsidian vault `02-Clients/Agents/_known_associations.md` 是 4 个经销商管理 Hook 升级 (commit `4b237a82`) 的输出。这页 index 是新引入的 cross-product mapping — connector 证据已在 [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) § "8-07 新增：_known_associations.md 索引" 索引。
 ## Maintenance
 - **Manual trigger:** notify Robin "update literature index"
 - **Automatic:** OpenWiki cron 02:00 daily runs the git-repo connector + observes the flywheel-sync jsonl; the `## Last 30 days of deep reads` section is updated by mtime census, and the `## Flywheel-sync pipeline` section is updated by inspecting the `flywheel_completed_at` field.
 - **Path:** `~/.openwiki/wiki/sources/literature.md` (synced to Gitea)
 ### 2026-08-11 - PMID 42041571
 - **Title**: Multiscale Comparative Analyses of OVB-Organoids and Cerebral Organoids
 - **Authors**: Yang J, Zhang X, Li S, Gao Z
 - **Journal**: Cells 2026, 15(8), 703 (MDPI, IF ~5.1, CC-BY OA)
 - **DOI**: 10.3390/cells15080703
 - **Wiki.js**: [ID 1708](http://10.10.10.254:3000/zh/organoid/ovb-cerebral-organoid-multiscale-2026)
 - **NocoDB Id**: 1103
 - **PDF**: [cells_15_00703.pdf](https://fb.biokingdom.top/f/582d1f055f6e4365a924/?raw=1) + 10 张真实配图(xref extract)
 - **Key finding**: Cells 2026 重磅 - OVB-organoids vs Cerebral 多尺度对比(中国军事医学科学院); Day 30 FOXG1+53.86% + VSX2+4.18%; TEM 突触+髓鞘; 1625 上调 + 2924 下调 DEGs; CHRNB2 6.5 倍差异; KEGG 富集到神经突触功能 vs 免疫炎症代谢
 - **Business relevance**: OVB-organoids + 3Brain MEA = 眼-脑协同发育研究完整解决方案
 - **Tags**: OVB-organoids, cerebral-organoids, brain-development, retinal-organoid, FOXG1, VSX2
 ### 2026-08-11 - PMID 41909700
 - **Title**: Organoid-microglia system for modeling the immune microenvironment of the brain and retina
 - **Authors**: Yu J, Tang B, Gu Z, Wang G, Liu A
 - **Journal**: Frontiers in Immunology 2026, 17:1747589
 - **DOI**: 10.3389/fimmu.2026.1747589
 - **Wiki.js**: [ID 1709](http://10.10.10.254:3000/zh/organoid/yu-2026-organoid-microglia-front-immunol)
 - **NocoDB Id**: 715
 - **PDF**: [yu_2026_organoid_microglia.pdf](https://fb.biokingdom.top/f/4537d08bf4d14c6db0bc/?dl=1) + 4 张真图
 - **Key finding**: 类器官-小胶质细胞共培养 3 大策略 + 6 大应用 (AD/ASD/视网膜/药筛/CRISPR/OoC); 神经-免疫体外模型空白填补
 - **Business relevance**: 3Brain MEA + CelVivo ClinoStar + Femtobiomed CellShot + Cellink BIO X 4 大产品线全交叉
 - **Tags**: 类器官, 小胶质细胞, 神经免疫, 脑-视网膜, 共培养
 ### 2026-08-11 - PMID 41686639
 - **Title**: High-throughput engineered tumor organoids reveal ROCK signaling as an immunotherapeutic target in triple-negative breast cancer
 - **Authors**: Zhou X, Zhu Y, Nicolas G, Wang Z, Lobie P, Ma S
 - **Journal**: Cell Reports 2026, 45:116987
 - **DOI**: 10.1016/j.celrep.2026.116987
 - **Wiki.js**: [ID 1710](http://10.10.10.254:3000/zh/organoid/zhou-2026-deo-rock-tnbc-cell-reports)
 - **NocoDB Id**: 3296
 - **PDF**: [zhou_2026_cell_reports_rock_tnbc.pdf](https://fb.biokingdom.top/f/bbe6f494811047c2bba0/?dl=1) + 6 张真图
 - **Key finding**: DEO 平台保留 TNBC 患者内源 TIL;ROCK 通路激动剂戊酸(PA)维持 TIL + 协同 anti-PD-1 解除 BLIS 亚型免疫抑制(联合治疗肿瘤抑制率 ~70%)
 - **Business relevance**: 4 大产品线全交叉 (CelVivo ClinoStar 培养/3Brain MEA 评估/Femtobiomed CellShot 基因编辑/Cellink BIO X 制造)
 - **Tags**: 肿瘤类器官, 三阴乳腺癌, ROCK信号, TIL, anti-PD-1, 戊酸, 马少华, BLIS亚型
 ### 2026-08-11 - PMID 41536916
 - **Title**: Artificial Intelligence Virtual Organoids (AIVOs)
 - **Authors**: Bai L, Su J
 - **Journal**: Bioactive Materials 2026 (IF 18.2)
 - **DOI**: 10.1016/j.bioactmat.2025.12.030
 - **Type**: Review
 - **Wiki.js**: [ID 1711](http://10.10.10.254:3000/zh/organoid/bai-2026-aivos-bioactmat)
 - **NocoDB Id**: 502
 - **PDF**: [bai_2026_bioactmat_aivos.pdf](https://fb.biokingdom.top/f/59c6a647037346a28197/?dl=1) + 6 张真图
 - **Key finding**: AI Virtual Organoids (AIVOs) = 物理类器官 + AI 数字孪生; 数据-模型-交互三层架构; 6 大临床应用方向
 - **Business relevance**: 4 大产品线 (CelVivo ClinoStar / 3Brain MEA / Femtobiomed CellShot / Cellink BIO X) 全部可对接 AIVOs 平台 = 完整 湿+干 实验方案
 - **Tags**: 综述, 类器官, 人工智能, 虚拟器官, 数字孪生, 多组学, Bioactive-Materials-2026
 | 10.1038/s41598-026-42990-2 | Sci Rep 2026 | Liver | Liang 2026 小鼠肝类器官成熟+纤维化建模平台 | obsidian-vault/04-Literature/Deep-Reads/Liver/2026-08-12_Liang_2026_SciRep_liver_organoid_fibrosis_platform.md |
@@ -1,9 +1,15 @@
 ---
 type: "Reference"
 title: "NocoDB 文献库索引 — 跨 agent 数据层"
 openwiki_generated: true
 ---
 # NocoDB 文献库索引 — 跨 agent 数据层
 > 数据源: NocoDB 13 个文献库 + 2 个公司库 (实时,每次 OpenWiki cron 跑时更新)
 > 用途: MiniMax code / Hermes 跨 agent 问 "Robin 的 NocoDB 里有什么"
-> 更新: 自动（\`~/.openwiki/update-sources.sh\` 每天 02:00 拉一次,数据写入本页后 commit + push Gitea）
+> 更新: 自动（`~/.openwiki/update-sources.sh` 每天 02:30 拉一次,数据写入本页后 commit + push Gitea）
-> 上次同步: **$(date -u +%Y-%m-%dT%H:%M:%SZ)** · **总记录数: ${NC_TOTAL}**
+> 上次同步: **2026-08-22T18:30:01Z** · **总记录数: 6620**
 ## 13 个文献库 (实测计数)
@@ -19,10 +25,11 @@
 | `m8abmmwrgchr9ni` | kidney_organoid_literature | 23 |
 | `mun191tsudjdtga` | retinal_organoid_literature | 4 |
 | `m65htyq25vmpysq` | Cellink_literature | 2499 |
-| `mri6u97xrxi0vvm` | organoid_literature (old) | 2772 |
+| `mri6u97xrxi0vvm` | organoid_literature (old) | 2786 |
 | `mr8wrky2um6gwev` | lung_organoid_literature | 48 |
 | `m76t4vsfar89w0h` | 3Brain_literature | 147 |
 ## 跟其他工具的互补关系
 - **RAGFlow** (KB) → 全文检索 (PDF 原文)
@@ -32,6 +39,6 @@
 ## 维护方式
- 自动触发: \`~/.local/bin/openwiki-update-sources.sh\` (每天 02:30 触发)
+- 自动触发: `~/.local/bin/openwiki-update-sources.sh` (每天 02:30 触发)
- 手动触发: \`bash ~/.local/bin/openwiki-update-sources.sh\`
+- 手动触发: `bash ~/.local/bin/openwiki-update-sources.sh`
- 数据格式: 跟 \`openclaw-imports/nocodb\` skill 共用
+- 数据格式: 跟 `openclaw-imports/nocodb` skill 共用
@@ -0,0 +1,18 @@
 ---
 type: Reference
 title: OpenWiki Upgrade Drift (auto-generated)
 last_checked: 2026-08-15T20:00:03Z
 ---
 # OpenWiki Upgrade Drift
 - Local installed: `v0.3.1`
 - npm latest: `v0.3.3`
 - Last checked: 2026-08-15T20:00:03Z
 ## Action (manual, no auto-upgrade)
 ```bash
 npm install -g openwiki@latest
 ```
 > **WARNING**: v0.3.1 → v0.4+ 可能有 breaking change. Read release notes first.
@@ -1,8 +1,15 @@
 ---
 type: "Reference"
 title: "RAGFlow 文档采样索引"
 description: "Document-level sample index of Robin's RAGFlow instance (http://10.10.10.254:9980) — 18 KBs / 32709 total docs / 401 sample entries (last sync 2026-08-03). Captures the 30-doc-per-request server-side limit + offset bug that forces 12 large KBs to single-page samples. Lets MiniMax code / Hermes see 'what's in each KB' without SQL queries; complements `/sources/ragflow.md` (KB-level health + counts)."
 tags: [ragflow, evidence-index, source, kb-documents, sample, 2026-08-13]
 ---
 # RAGFlow 文档采样索引
 > Data source: RAGFlow (`http://10.10.10.254:9980`) 18 KB
 > 18 KB total documents: **32709** · samples in this index: **401**
-> Last sync: **2026-07-27T18:30:06Z**
+> Last sync: **2026-08-03T18:30:07Z**
 > 目的: 让 Robin 跟 MiniMax code / Hermes **cross-agent 知道每个 KB 里有什么** — 不用 SQL 查询, 直接看 wiki。
 > ⚠️ **RAGFlow 0.17 server-side 强制限 30 doc per request, 且 `offset` 参数 server 端被忽略 (已实测, 多次 offset 返相同 30 个)**。所以
@@ -166,30 +173,30 @@ _Dataset ID: `06af5550559d11f1bbe76d8b6ef5373a`_
 | 4 | 2026-07-14 | Bio-protocol5708.pdf | 42 |
 | 5 | 2026-07-14 | 111419-v1.pdf | 22 |
 | 6 | 2026-07-14 | 1-s2.0-S1385894726050369-main.pdf | 24 |
-| 7 | 2026-05-31 | 7.pdf | 54 |
+| 7 | 2026-05-31 | 55.pdf | 28 |
-| 8 | 2026-05-31 | 70.pdf | 38 |
+| 8 | 2026-05-31 | 20210303-ahead-3Brain-press-release.pdf | 2 |
-| 9 | 2026-05-31 | 68.pdf | 62 |
+| 9 | 2026-05-31 | Multi-well HD-MEA (24 well) Platform _ HyperCAM Delta _ 3Brain(2).pdf | 11 |
-| 10 | 2026-05-31 | Protocol for Culturing Primary Rat Mouse Embryonic Neurons on CorePlateTM.pdf | 6 |
+| 10 | 2026-05-31 | 类器官及MEA海报(1).pdf | 3 |
-| 11 | 2026-05-31 | HBIO_2024_256-9wellMEA_Datasheet.pdf | 10 |
+| 11 | 2026-05-31 | s41380-026-03470-1.pdf | 28 |
-| 12 | 2026-05-31 | 3brain脑机接口(1).pdf | 2 |
+| 12 | 2026-05-31 | 2022-08-15_3Brain_CSEM_Accura-3D(2).pdf | 7 |
-| 13 | 2026-05-31 | MEA彩页-汇佰-20251103-5.pdf | 39 |
+| 13 | 2026-05-31 | 77.pdf | 38 |
-| 14 | 2026-05-31 | 22.pdf | 31 |
+| 14 | 2026-05-31 | 6.pdf | 40 |
-| 15 | 2026-05-31 | 8.pdf | 57 |
+| 15 | 2026-05-31 | 31.pdf | 55 |
-| 16 | 2026-05-31 | 2025.06.04.657874v1.full-mono.pdf | 53 |
+| 16 | 2026-05-31 | 20250120-2770739-ozrr5m-mono.pdf | 22 |
-| 17 | 2026-05-31 | PIIS2667237525003315111.pdf | 115 |
+| 17 | 2026-05-31 | Intermittent_Propofol_Exposure_Induces_Neurodevelo.pdf | 47 |
-| 18 | 2026-05-31 | 60.OConnellKwakowsky2025NRR(1).pdf | 9 |
+| 18 | 2026-05-31 | MEA Software _ Axion Biosystems.pdf | 2 |
-| 19 | 2026-05-31 | 37.pdf | 50 |
+| 19 | 2026-05-31 | ssrn-5575434.pdf | 53 |
-| 20 | 2026-05-31 | 35.pdf | 38 |
+| 20 | 2026-05-31 | 14.pdf | 35 |
-| 21 | 2026-05-31 | 55.pdf | 28 |
+| 21 | 2026-05-31 | X---PIIS193459092400290X.pdf | 53 |
-| 22 | 2026-05-31 | Protocol for Dissecting and Recording Mouse Retinal Explants with CorePlateTM-mo... | 4 |
+| 22 | 2026-05-31 | 5.pdf | 57 |
-| 23 | 2026-05-31 | 2023_Kim_et_al_Int._J._Mol._Sci..pdf | 28 |
+| 23 | 2026-05-31 | CorePlate-1W_Perfusion-System-Components-and-Set-Up.pdf | 13 |
-| 24 | 2026-05-31 | 7-1.pdf | 41 |
+| 24 | 2026-05-31 | Publications _ 3Brain(2).pdf | 75 |
-| 25 | 2026-05-31 | Multi-well HD-MEA _ CorePlate™ 24W _ 3Brain.pdf | 3 |
+| 25 | 2026-05-31 | 3Brain高分辨微电极阵列分析系统 _ Biokingdom(1).pdf | 23 |
-| 26 | 2026-05-31 | CorePlate-1W-3D-38-60-90_ApplicationNote_Zonal-Analysis-of-Brain-Assembloid.pdf | 13 |
+| 26 | 2026-05-31 | 3Brain MEA文献列表 _ Biokingdom(3).pdf | 0 |
-| 27 | 2026-05-31 | CorePlate-1W-6W_TechnicalNote_Sample-Holder-V1-User-Guide.pdf | 13 |
+| 27 | 2026-05-31 | CorePlate-6W-38-60_Handling-Cleaning-Sterilization-Hydrophilization-Guide.pdf | 6 |
-| 28 | 2026-05-31 | Protocol for tailored in vitro neuronal networks on high-density microelectrode ... | 93 |
+| 28 | 2026-05-31 | 57.pdf | 46 |
-| 29 | 2026-05-31 | 19.pdf | 72 |
+| 29 | 2026-05-31 | Multi-well HD-MEA _ CorePlate™ 24W _ 3Brain.pdf | 3 |
-| 30 | 2026-05-31 | CorePlate-6W-38-60_TechnicalNote_Prep-Guide.pdf | 6 |
+| 30 | 2026-05-31 | 3Brain MEA文献列表 _ Biokingdom(2).pdf | 0 |
 ## Cellink  (340 docs · 30 sampled · 9% coverage)
 _Dataset ID: `cf973e0e559f11f1bbe76d8b6ef5373a`_
@@ -202,30 +209,30 @@ _Dataset ID: `cf973e0e559f11f1bbe76d8b6ef5373a`_
 | 4 | 2026-07-13 | Levine_2024_Metoprolol_Custom_Dosed.pdf | 57 |
 | 5 | 2026-07-13 | Hu_2023_Carbamazepine_ODT.pdf | 75 |
 | 6 | 2026-07-13 | Holkunde_2025_Dual_Drug_Gummies.pdf | 68 |
-| 7 | 2026-05-31 | Organoids _ Biokingdom-mono_layout.pdf | 164 |
+| 7 | 2026-05-31 | Macromolecular Bioscience - 2023 - Duong - Digital Light Processing 3D Bioprinti... | 37 |
-| 8 | 2026-05-31 | 1-s2.0-S2452199X23000300-main.pdf | 63 |
+| 8 | 2026-05-31 | 42114_2025_Article_1546.pdf | 42 |
-| 9 | 2026-05-31 | nihms-1745586.pdf | 94 |
+| 9 | 2026-05-31 | Development of a porcine decellularized extracellular matrix  DECM  bioink for 3... | 37 |
-| 10 | 2026-05-31 | 1-s2.0-S2452199X24003165-main.pdf | 52 |
+| 10 | 2026-05-31 | PIIS2405844024006248.pdf | 60 |
-| 11 | 2026-05-31 | Untitled Page _ Biokingdom-mono.pdf | 52 |
+| 11 | 2026-05-31 | Advanced Science - 2025 - Li - Bioprinted Organoids  An Innovative Engine in Bio... | 37 |
-| 12 | 2026-05-31 | High-resolution CMOS-based biosensor for assessing hippocampal circuit dynamics ... | 51 |
+| 12 | 2026-05-31 | High-resolution CMOS-based biosensor for assessing hippocampal circuit dynamics ... | 53 |
-| 13 | 2026-05-31 | Development of a porcine decellularized extracellular matrix  DECM  bioink for 3... | 37 |
+| 13 | 2026-05-31 | Small - 2025 - Kilic - 3D‐Printed Crosslinked Nanocellulose‐MXene Hydrogels and ... | 35 |
 | 14 | 2026-05-31 | Derman_2025_Int._J._Extrem._Manuf._7_012009.pdf | 110 |
-| 15 | 2026-05-31 | acs.chemrev.0c00077.pdf | 289 |
+| 15 | 2026-05-31 | Adv Healthcare Materials - 2025 - Ganguly - Fluid Shear‐Controlled Pro Anti‐Infl... | 46 |
-| 16 | 2026-05-31 | Advanced Science - 2026 - Spagnuolo - Bioprinting of Microtissues Within Mechani... | 43 |
+| 16 | 2026-05-31 | GJHS-8-190.pdf | 15 |
-| 17 | 2026-05-31 | 1-s2.0-S0268005X25007556-mainext.pdf | 39 |
+| 17 | 2026-05-31 | High-resolution CMOS-based biosensor for assessing hippocampal circuit dynamics ... | 51 |
-| 18 | 2026-05-31 | 1-s2.0-S1742706120304013-main.pdf | 49 |
+| 18 | 2026-05-31 | 1-s2.0-S0268005X25007556-mainext.pdf | 39 |
-| 19 | 2026-05-31 | 1-s2.0-S2452199X24005176-main.pdf | 62 |
+| 19 | 2026-05-31 | s41467-023-40379-7.pdf | 26 |
-| 20 | 2026-05-31 | Small Science - 2024 - Madadian - In‐Foam Bioprinting  An Embedded Bioprinting T... | 29 |
+| 20 | 2026-05-31 | Recent_advances_in_3d_printed_biomaterials.pdf | 141 |
-| 21 | 2026-05-31 | 20865-adv-funct-materials-2022-magnetically‐assisted-3d-bioprinting-anisotropic-... | 52 |
+| 21 | 2026-05-31 | PIIS1934590923004393.pdf | 50 |
-| 22 | 2026-05-31 | ADHM-14-0.pdf | 86 |
+| 22 | 2026-05-31 | emulating-human-tissues-and-organs-a-bioprinting-perspective-toward-personalized... | 170 |
-| 23 | 2026-05-31 | Organoids _ Biokingdom.pdf | 60 |
+| 23 | 2026-05-31 | s42003_CommunBiol2025.pdf | 59 |
-| 24 | 2026-05-31 | 1-s2.0-S2095809921003301-main.pdf | 34 |
+| 24 | 2026-05-31 | 1-s2.0-S0141813024034160-main.pdf | 47 |
-| 25 | 2026-05-31 | main (2).pdf | 41 |
+| 25 | 2026-05-31 | Protocol for tailored in vitro neuronal networks on high-density microelectrode ... | 93 |
-| 26 | 2026-05-31 | Small Science - 2024 - Li - Engineering Conductive Hydrogels with Tissue‐like Pr... | 35 |
+| 26 | 2026-05-31 | Small Science - 2024 - Madadian - In‐Foam Bioprinting  An Embedded Bioprinting T... | 29 |
-| 27 | 2026-05-31 | Advanced Materials - 2025 - Tavakoli - Ultra‐Fine 3D Bioprinting of Dynamic Hyal... | 55 |
+| 27 | 2026-05-31 | Organoid assessment technologies _ Biokingdom-mono.pdf | 54 |
-| 28 | 2026-05-31 | Human cerebral organoids  a new tool for clinical neurology research _ Biokingdo... | 80 |
+| 28 | 2026-05-31 | Protocol for tailored in vitro neuronal networks on high-density microelectrode ... | 52 |
-| 29 | 2026-05-31 | Adv Funct Materials - 2025 - Robazzi - The Synergy of Artificial Intelligence an... | 117 |
+| 29 | 2026-05-31 | Untitled Page _ Biokingdom-mono.pdf | 52 |
-| 30 | 2026-05-31 | Recent_advances_in_3d_printed_biomaterials.pdf | 141 |
+| 30 | 2026-05-31 | Organoids _ Biokingdom-mono_layout.pdf | 164 |
 ## Celvivo  (154 docs · 30 sampled · 19% coverage)
 _Dataset ID: `1555e5b2783211f1ae98677f0bb5075b`_
@@ -268,31 +275,31 @@ _Dataset ID: `e3203cec58ff11f1b30fafc58ab1b683`_
 | # | Date | Doc name | Chunks |
 | ---: | --- | --- | ---: |
-| 1 | 2026-05-31 | Supported models _ RAGFlow.pdf | 5 |
+| 1 | 2026-05-31 | Switch component _ RAGFlow.pdf | 1 |
-| 2 | 2026-05-31 | Manage metadata _ RAGFlow.pdf | 4 |
+| 2 | 2026-05-31 | RAGFlow MCP tools _ RAGFlow.pdf | 1 |
-| 3 | 2026-05-31 | Acquire RAGFlow API key _ RAGFlow.pdf | 3 |
+| 3 | 2026-05-31 | Build Ecommerce customer support agent _ RAGFlow.pdf | 7 |
-| 4 | 2026-05-31 | Agent component _ RAGFlow.pdf | 10 |
+| 4 | 2026-05-31 | Manage team members _ RAGFlow.pdf | 4 |
-| 5 | 2026-05-31 | Text processing component _ RAGFlow.pdf | 1 |
+| 5 | 2026-05-31 | Manage metadata _ RAGFlow.pdf | 4 |
-| 6 | 2026-05-31 | Add Bitbucket _ RAGFlow.pdf | 2 |
+| 6 | 2026-05-31 | Agent component _ RAGFlow.pdf | 10 |
-| 7 | 2026-05-31 | Switch component _ RAGFlow.pdf | 1 |
+| 7 | 2026-05-31 | Add Bitbucket _ RAGFlow.pdf | 2 |
 | 8 | 2026-05-31 | Execute SQL tool _ RAGFlow.pdf | 2 |
-| 9 | 2026-05-31 | Set page rank _ RAGFlow.pdf | 2 |
+| 9 | 2026-05-31 | Use memory _ RAGFlow.pdf | 5 |
-| 10 | 2026-05-31 | Releases _ RAGFlow.pdf | 18 |
+| 10 | 2026-05-31 | Supported models _ RAGFlow.pdf | 5 |
-| 11 | 2026-05-31 | Contribution guidelines _ RAGFlow.pdf | 1 |
+| 11 | 2026-05-31 | Releases _ RAGFlow.pdf | 18 |
 | 12 | 2026-05-31 | Add Notion _ RAGFlow.pdf | 2 |
-| 13 | 2026-05-31 | Manage team members _ RAGFlow.pdf | 4 |
+| 13 | 2026-05-31 | Set page rank _ RAGFlow.pdf | 2 |
-| 14 | 2026-05-31 | HTTP request component _ RAGFlow.pdf | 12 |
+| 14 | 2026-05-31 | Text processing component _ RAGFlow.pdf | 1 |
-| 15 | 2026-05-31 | Use memory _ RAGFlow.pdf | 5 |
+| 15 | 2026-05-31 | HTTP request component _ RAGFlow.pdf | 12 |
-| 16 | 2026-05-31 | RAGFlow MCP tools _ RAGFlow.pdf | 1 |
+| 16 | 2026-05-31 | Glossary _ RAGFlow.pdf | 2 |
-| 17 | 2026-05-31 | Transformer component _ RAGFlow.pdf | 2 |
+| 17 | 2026-05-31 | Use tag set _ RAGFlow.pdf | 3 |
 | 18 | 2026-05-31 | RAGFlow MCP client examples _ RAGFlow.pdf | 4 |
 | 19 | 2026-05-31 | Configure model API key _ RAGFlow.pdf | 2 |
 | 20 | 2026-05-31 | Launch service from source _ RAGFlow.pdf | 3 |
 | 21 | 2026-05-31 | Start AI chat _ RAGFlow.pdf | 6 |
 | 22 | 2026-05-31 | Upgrading _ RAGFlow.pdf | 2 |
-| 23 | 2026-05-31 | Extract table of contents _ RAGFlow.pdf | 3 |
+| 23 | 2026-05-31 | Switch document engine _ RAGFlow.pdf | 1 |
-| 24 | 2026-05-31 | Build Ecommerce customer support agent _ RAGFlow.pdf | 7 |
+| 24 | 2026-05-31 | Set variables _ RAGFlow.pdf | 3 |
-| 25 | 2026-05-31 | Await response component _ RAGFlow.pdf | 1 |
+| 25 | 2026-05-31 | Contribution guidelines _ RAGFlow.pdf | 1 |
 | 26 | 2026-05-31 | Enable RAPTOR _ RAGFlow.pdf | 6 |
 | 27 | 2026-05-31 | Enable Excel2HTML _ RAGFlow.pdf | 2 |
 | 28 | 2026-05-31 | Build RAGFlow Docker image _ RAGFlow.pdf | 2 |
@@ -1,29 +1,25 @@
-> Data source: RAGFlow (`http://10.10.10.254:9980`) — 14+ KB full-text retrieval results (RAGFlow server direct return)
+---
-> Real KB count: **18** · Total documents: **32709** · Total chunks: **116254**
+type: "Reference"
-> Purpose: MiniMax code / Hermes cross-agent query 'what is in Robin RAGFlow'
+title: "RAGFlow 全文检索索引 (Robin KB system)"
-> Update: Auto (daily 02:30 `openwiki-update-sources.sh` runs, directly hits RAGFlow for real KB list)
+openwiki_generated: true
-> Last sync: **2026-07-27T18:30:03Z** · landing 200 · /api/v1/health 404 · /api/v1/datasets 401
+---
-## 18 KB actual state (RAGFlow server direct)
+# RAGFlow 全文检索索引 (Robin KB system)
-| Name | Dataset ID | Docs | Chunks | Created | Embed model |
+> 数据源: RAGFlow (http://10.10.10.254:9980/) 14 个 KB 全文检索结果
-| --- | --- | ---: | ---: | --- | --- |
+> 用途: MiniMax code / Hermes 跨 agent 问 "Robin 的 RAGFlow 里有什么"
-| 废弃库 | daa9ee22676511f199eda760f7ee5ce3 | 15922 | 1604 | 2026-06-13 | nomic-embed-text@Ollama |
+> 更新: 自动同步可用性 + 手动维护 KB 列表
-| Organoid1 | 8dfa438274e511f192005b500fef9793 | 7815 | 8714 | 2026-07-01 | BAAI/bge-m3@LM-Studio |
+> 上次同步: **2026-08-22T18:30:02Z** · landing 200 · /api/v1/datasets 401
-| Organoid2 | 044cdb54762011f192005b500fef9793 | 4974 | 5888 | 2026-07-02 | BAAI/bge-m3@LM-Studio |
+
-| Organoid | 3c063ce2559c11f1bbe76d8b6ef5373a | 2514 | 30978 | 2026-05-22 | nomic-embed-text@Ollama |
+## RAGFlow 服务可用性
-| 3Brian | 06af5550559d11f1bbe76d8b6ef5373a | 454 | 19374 | 2026-05-22 | nomic-embed-text@Ollama |
+
-| Cellink | cf973e0e559f11f1bbe76d8b6ef5373a | 340 | 26200 | 2026-05-22 | nomic-embed-text@Ollama |
+| Endpoint | HTTP code | 含义 |
-| Celvivo | 1555e5b2783211f1ae98677f0bb5075b | 154 | 9027 | 2026-07-05 | BAAI/bge-m3@LM-Studio |
+| --- | --- | --- |
-| RAGFlow | e3203cec58ff11f1b30fafc58ab1b683 | 128 | 1268 | 2026-05-26 | nomic-embed-text@Ollama |
+| GET / (landing) | 200 | 控制台可达 |
-| FemtoBiomed_electroporation | c97eb5606aa811f199eda760f7ee5ce3 | 123 | 142 | 2026-06-18 | BAAI/bge-m3@LM-Studio |
+| GET /api/v1/health | 404 | API 健康 |
-| Celvivo1 | a83244a855c211f1bbe76d8b6ef5373a | 90 | 4699 | 2026-05-22 | nomic-embed-text@Ollama |
+| GET /api/v1/datasets | 401 | KB 列表 endpoint |
-| seer | 79bfa1386a2611f199eda760f7ee5ce3 | 81 | 3194 | 2026-06-17 | text-embedding-v4@Tongyi-Qianwen |
+
-| cellshot | 35d3e1bc680c11f199eda760f7ee5ce3 | 73 | 3556 | 2026-06-14 | BAAI/bge-m3@LM-Studio |
+> 注意: 2026-07-17 起 Robin 桌面 embedding / bge-reranker 服务宕机,导致 NAS 上 RAGFlow KB retrieval (向量检索) 不可用,但元数据 + 文档下载仍 OK,KB 内容同步 (chunks 拉 + 本地 keyword grep) 走降级路径。
-| LaminarWash | 1ccc414278d211f18f37855334215f14 | 21 | 1257 | 2026-07-06 | BAAI/bge-m3@LM-Studio |
+
-| Celvivo commercial | 922cde0880aa11f190f421d810cb6a77 | 10 | 40 | 2026-07-16 | BAAI/bge-m3@LM-Studio |
+## 14 个 KB 状态 (验证于 2026-07-16)
-| Cellshot厂家 | 437d31de7a7b11f18f37855334215f14 | 5 | 49 | 2026-07-08 | BAAI/bge-m3@LM-Studio |
+...
 | huibaibio | 92604bda7aab11f18f37855334215f14 | 3 | 107 | 2026-07-08 | BAAI/bge-m3@LM-Studio |
 | Organoid3 | 29d5de0a7ff511f190f421d810cb6a77 | 1 | 57 | 2026-07-15 | BAAI/bge-m3@LM-Studio |
 | nanotemper | 496748f66a2611f199eda760f7ee5ce3 | 1 | 100 | 2026-06-17 | nomic-embed-text@Ollama |
 | **TOTAL** | | **32709** | **116254** | | |
@@ -0,0 +1,722 @@
 ---
 type: "Reference"
 title: "RustDesk 自建 hbbs 完整配置笔记 (2026-08-05)"
 description: "End-to-end deployment note for Robin's self-hosted RustDesk relay server (hbbs + hbbr) — Unraid NAS container (10.10.10.254) + OpenWrt reverse-proxy (10.10.10.252) + Tencent Light Cloud (43.160.207.177) + ITX client (192.168.31.14), with permanent password + key config. Supports remote control of the ITX 24h host (per `/commitments.md` `itx-24h-host-build-2026-q3`) and Robin's travel-laptop remote-access workflow."
 tags: [rustdesk, itx-24h-host, remote-access, sop, infra, 2026-08-13]
 ---
 # RustDesk 自建 hbbs 完整配置笔记 (2026-08-05)
 > **写于**: 2026-08-05 22:20 (本机时间)
 > **作者**: Hermes agent
 > **适用**: Robin (ITX 远程控制 / 出差笔记本控制)
 > **状态**: ✅ 链路完全跑通, 笔记本待装
 ---
 ## 0. 摘要 (TL;DR)
 **自建 RustDesk 中继服务器 (`hbbs + hbbr`) 已完成端到端部署**, 包含:
 - **NAS 容器** (Unraid 10.10.10.254) 跑 hbbs + hbbr
 - **OpenWrt 路由器** (10.10.10.252) 反代透 NAS 端口到 Tencent 公网
 - **Tencent 轻量云** (43.160.207.177) frps + 防火墙 5 条放行
 - **ITX** (192.168.31.14) 装 rustdesk 1.4.9 客户端, 自建 hbbs 注册成功
 - **永久密码**: `Ldw811223!`
 **未来笔记本 / 手机装 rustdesk 客户端配置后**:
 - ID Server: `43.160.207.177`
 - Relay Server: `43.160.207.177`
 - Key: `eYHdhv6c5+dUsaOx6EYWBSSPss6F1qtKk+18tgyURew=`
 - 连 ITX: ID = `263 739 134`, 永久密码 = `Ldw811223!`
 ---
 ## 1. 架构图
 ```
                       ┌─────────────────────────────────┐
                       │  Tencent 轻量云                 │
                       │  43.160.207.177                 │
                       │  - Nginx Proxy Manager (:81)    │
                       │  - frps (port 5443, token)      │
                       │  - 防火墙 5 条放行              │
                       └──────────┬──────────────────────┘
                                  │ frp 加密隧道
                                  ▼
                       ┌─────────────────────────────────┐
                       │  OpenWrt 路由器                 │
                       │  10.10.10.252                   │
                       │  - br-lan                       │
                       │  - frpc 连 frps 5443            │
                       │  - 5 条 rustdesk tunnel         │
                       └──────────┬──────────────────────┘
                                  │ LAN
                                  ▼
                       ┌─────────────────────────────────┐
                       │  NAS Unraid                     │
                       │  10.10.10.254                   │
                       │  - docker container: hbbs      │
                       │    - 0.0.0.0:21115 TCP           │
                       │    - 0.0.0.0:21116 TCP+UDP       │
                       │  - docker container: hbbr      │
                       │    - 0.0.0.0:21117 TCP           │
                       │  - data 持久化:                 │
                       │    /mnt/user/docker/            │
                       │    rustdesk-server-aio/data/    │
                       └─────────────────────────────────┘
                                  ▲
                                  │ 局域网
                                  │
                       ┌──────────┴──────────────────────┐
                       │  ITX 被控端                    │
                       │  192.168.31.14                  │
                       │  - rustdesk 1.4.9               │
                       │  - X11 (WaylandEnable=false)    │
                       │  - systemd: rustdesk.service    │
                       │  - 永久密码 Ldw811223!         │
                       │  - 9 位 ID: 263 739 134        │
                       │  - 配置: 43.160.207.177:21116  │
                       └─────────────────────────────────┘
                                  ▲
                                  │ 公网 (走 NAS hbbs 中继)
                                  │
                       ┌──────────┴──────────────────────┐
                       │  控制端 (笔记本 / 手机)         │
                       │  出差时: 装 rustdesk 客户端    │
                       │  - ID Server: 43.160.207.177    │
                       │  - Key: eYHdhv6c5+...           │
                       │  - 输入 ITX ID: 263 739 134     │
                       │  - 永久密码: Ldw811223!         │
                       └─────────────────────────────────┘
 ```
 ---
 ## 2. NAS 端 - hbbs + hbbr 容器
 ### 2.1 Docker run 命令
 ```bash
 # hbbs (ID 注册 + 密钥协商服务器)
 docker run -d \
  --name rustdesk-hbbs \
  --restart always \
  --network host \
  -v /mnt/user/docker/rustdesk-server-aio/data:/root \
  rustdesk/rustdesk-server:latest \
  hbbs
 # hbbr (relay 中继服务器)
 docker run -d \
  --name rustdesk-hbbr \
  --restart always \
  --network host \
  -v /mnt/user/docker/rustdesk-server-aio/data:/root \
  rustdesk/rustdesk-server:latest \
  hbbr
 ```
 ### 2.2 持久化数据目录
 ```
 /mnt/user/docker/rustdesk-server-aio/data/
 ├── id_ed25519            # 服务器私钥
 ├── id_ed25519.pub        # 服务器公钥 (客户端需要填的 key)
 └── db_v2.sqlite3         # peer 注册表 (包含 ITX ID 263739134)
 ```
 ### 2.3 hbbs 启动关键日志
 ```
 [INFO] [src/common.rs:147] Private/public key written to id_ed25519/id_ed25519.pub
 [INFO] [src/rendezvous_server.rs:1243] Key: eYHdhv6c5+dUsaOx6EYWBSSPss6F1qtKk+18tgyURew=
 [INFO] [src/rendezvous_server.rs:193] Start
 ```
 ### 2.4 验证 peer 注册
 ```bash
 sqlite3 /mnt/user/docker/rustdesk-server-aio/data/db_v2.sqlite3 <<EOSQL
 SELECT id, length(pk), datetime(created_at,'unixepoch') FROM peer;
 EOSQL
 # 输出 (ITX 已注册):
 # 263739134 | 32 | NULL  ← ITX 的 9 位 ID
 ```
 ### 2.5 容器状态验证
 ```bash
 docker ps --filter name=rustdesk
 # 应输出:
 # rustdesk-hbbs  Up ...  rustdesk-server:latest  hbbs
 # rustdesk-hbbr  Up ...  rustdesk-server:latest  hbbr
 docker stats --no-stream rustdesk-hbbs rustdesk-hbbr
 # 确认 NET I/O > 0 (有流量进出)
 ```
 ---
 ## 3. OpenWrt 路由器 - frpc 透 NAS 端口到公网
 ### 3.1 文件路径
 ```
 /etc/config/frp        # UCI 真源
 /var/etc/frp/frpc.conf # 生成 (不要直接编辑)
 ```
 ### 3.2 UCI 追加条目 (10.10.10.252)
 **重要**: `/etc/config/frp` 由 LuCI frp 插件管理, 任何对 `/var/etc/frp/frpc.conf` 的直接编辑都会被 **UCI 重写覆盖**。
 **正确方式**: 编辑 `/etc/config/frp` 末尾加 6 行 config proxy 块, 然后 `/etc/init.d/frp restart`:
 ```bash
 # ssh root@10.10.10.252
 # 备份
 cp /etc/config/frp /etc/config/frp.bak.20260805-tcp21116
 # 追加新 config proxy 块
 cat >> /etc/config/frp << 'UCIEND'
 config proxy
 	option enable '1'
 	option type 'tcp'
 	option remote_port '21116'
 	option local_ip '10.10.10.254'
 	option local_port '21116'
 	option proxy_protocol_version 'disable'
 	option use_encryption '1'
 	option use_compression '1'
 	option remark 'rustdesk-tcp-21116'
 UCIEND
 # 重启 frp 服务 (触发 UCI → frpc.conf 重生成)
 uci commit frp
 /etc/init.d/frp restart
 # 验证
 tail -20 /var/etc/frp/frpc.conf
 # 应包含 [rustdesk-tcp-21116] section
 grep 'rustdesk-tcp-21116' /var/etc/frp/frpc.log
 # 应输出: [rustdesk-tcp-21116] start proxy success
 ```
 ### 3.3 所有 5 条 rustdesk tunnel 状态
 | 规则名 | 类型 | remote_port | local_ip | local_port | 作用 |
 |---|---|---|---|---|---|
 | rustdesk-hbbs | TCP | 21115 | 10.10.10.254 | 21115 | NAT test |
 | rustdesk-udp | UDP | 21116 | 10.10.10.254 | 21116 | 注册 + 打洞 |
 | rustdesk-tcp | TCP | 21117 | 10.10.10.254 | 21117 | relay |
 | rustdesk-tcp-21116 | TCP | 21116 | 10.10.10.254 | 21116 | **TCP 注册 (关键新增)** |
 | rustdesk-web | HTTP | remote.biokingdom.top:80 | 10.10.10.254 | 3996 | web client |
 **注意**: TCP 21116 与 UDP 21116 共享端口 — frp 配置里是分开的 (类型不同不冲突)。
 ---
 ## 4. Tencent 防火墙 5 条放行规则
 ### 4.1 控制台 → 防火墙 → 添加规则
 | 序号 | 应用类型 | 来源 | 协议 | 端口 | 策略 | 备注 |
 |---|---|---|---|---|---|---|
 | 1 | 自定义 | 全部IPv4地址 | TCP | 21115 | 允许 | rustdesk-hbbs |
 | 2 | 自定义 | 全部IPv4地址 | TCP | 21116 | 允许 | rustdesk-21116tcp |
 | 3 | 自定义 | 全部IPv4地址 | UDP | 21116 | 允许 | rustdesk-udp-rendezvous |
 | 4 | 自定义 | 全部IPv4地址 | TCP | 21117 | 允许 | rustdesk-relay |
 | 5 | 自定义 | 全部IPv4地址 | TCP | 21118 | 允许 | rustdesk-web (可选) |
 ### 4.2 验证 (从 ITX 端)
 ```bash
 # TCP
 nc -zv -w5 43.160.207.177 21115  # succeeded
 nc -zv -w5 43.160.207.177 21116  # succeeded
 nc -zv -w5 43.160.207.177 21117  # succeeded
 # UDP
 nc -zvu -w5 43.160.207.177 21116  # succeeded
 ```
 **注意**: TCP 21116 之前 TIMEOUT 是因为 OpenWrt frpc 没加 rustdesk-tcp-21116 规则。**加完后立刻成功**。
 ---
 ## 5. ITX 被控端配置 (192.168.31.14)
 ### 5.1 安装
 ```bash
 sudo dpkg -i /home/ldw/下载/rustdesk-1.4.9-x86_64.deb
 sudo apt-get install -fy  # 装依赖 libxdo3
 ```
 ### 5.2 关键环境修复: Wayland → X11
 **问题**: Ubuntu 22.04 默认 Wayland, RustDesk 1.4.9 在 Wayland 下 IPC 通讯失败, GUI 设置无法写入 toml。
 **修复**:
 ```bash
 # 备份
 sudo cp /etc/gdm3/custom.conf /etc/gdm3/custom.conf.bak.20260805
 # 修改: 取消注释 WaylandEnable=false
 sudo sed -i 's/^#WaylandEnable=false/WaylandEnable=false/' /etc/gdm3/custom.conf
 # 重启 GDM
 sudo systemctl restart gdm
 # (重登录选 "Ubuntu on Xorg" 或自动登录)
 ```
 **验证**:
 ```bash
 loginctl show-session $(loginctl | grep '^\s*[0-9]' | head -1 | awk '{print $1}') | grep -i type
 # 应输出: Type=x11 (而不是 wayland)
 ```
 ### 5.3 systemd unit (default)
 ```ini
 # /usr/lib/systemd/system/rustdesk.service
 [Unit]
 Description=RustDesk
 Requires=network.target
 After=systemd-user-sessions.service
 [Service]
 Type=simple
 ExecStart=/usr/bin/rustdesk --service
 ExecStop=/usr/bin/pkill -f "rustdesk --"
 PIDFile=/run/rustdesk.pid
 KillMode=mixed
 TimeoutStopSec=30
 User=root
 LimitNOFILE=100000
 Environment="PULSE_LATENCY_MSEC=60" "PIPEWIRE_LATENCY=1024/48000"
 [Install]
 WantedBy=multi-user.target
 ```
 ### 5.4 配置 toml (两套都要写, 因 service 启动可能用其中之一)
 **路径**:
 - `/root/.config/rustdesk/RustDesk2.toml` (root 用户, service 启动时读)
 - `/home/ldw/.config/rustdesk/RustDesk2.toml` (ldw 用户, --server 启动时读)
 **内容**:
 ```toml
 rendezvous_server = '43.160.207.177:21116'
 nat_type = 2
 serial = 0
 unlock_pin = ''
 trusted_devices = ''
 [options]
 local-ip-addr = '192.168.31.14'
 custom-rendezvous-server = '43.160.207.177'
 relay-server = '43.160.207.177'
 password = 'Ldw811223!'
 key = 'eYHdhv6c5+dUsaOx6EYWBSSPss6F1qtKk+18tgyURew='
 av1-test = 'Y'
 verification-method = 'use-permanent-password'
 ```
 ### 5.5 永久密码
 **字段**: `[options].password = 'Ldw811223!'`
 **GUI 流程** (如手动):
 1. RustDesk 主界面右上角 ≡ → Settings
 2. 安全 → 密码 → "使用固定密码" → "设置固定密码"
 3. 输入 `Ldw811223!` 两次 → 确定 → 输 6 位 PIN (任意如 `123456`)
 4. Restart rustdesk service
 ### 5.6 ITX 9 位 ID
 ```
 263 739 134
 ```
 (由 hbbs 自动分配, 写进 NAS db_v2.sqlite3)
 ### 5.7 自启动配置
 ```bash
 sudo systemctl daemon-reload
 sudo systemctl enable rustdesk.service
 sudo systemctl start rustdesk.service
 systemctl is-enabled rustdesk.service
 # enabled
 systemctl is-active rustdesk.service
 # active
 ```
 ### 5.8 验证 ITX 注册到 hbbs
 ```bash
 # ITX 端看 ss 连接
 ss -tnp | grep rustdesk
 # SYN-SENT 0 1 192.168.31.14:51010 43.160.207.177:21114 (rustdesk 偶尔 ping API)
 # SYN-SENT 0 1 192.168.31.14:34322 43.160.207.177:21116 (注册主路径)
 # NAS 端看 peer
 sqlite3 /mnt/user/docker/rustdesk-server-aio/data/db_v2.sqlite3 "SELECT count(*), id FROM peer"
 # 1 | 263739134
 ```
 ---
 ## 6. 台机控制端配置 (192.168.192.67)
 ### 6.1 安装 (Windows)
 ```powershell
 # 下载 1.4.9 Windows exe
 # https://github.com/rustdesk/rustdesk/releases/download/1.4.9/rustdesk-1.4.9-x86_64.exe
 # 静默安装
 rustdesk-1.4.9-x86_64.exe --silent-install
 ```
 ### 6.2 配置文件 (SFTP 上传)
 **路径**: `C:\Users\Administrator\AppData\Roaming\RustDesk\config\RustDesk2.toml`
 ```toml
 rendezvous_server = '43.160.207.177:21116'
 nat_type = 1
 serial = 0
 unlock_pin = ''
 trusted_devices = ''
 [options]
 custom-rendezvous-server = '43.160.207.177'
 relay-server = '43.160.207.177'
 key = 'eYHdhv6c5+dUsaOx6EYWBSSPss6F1qtKk+18tgyURew='
 local-ip-addr = '192.168.31.126'
 av1-test = 'Y'
 password = ''
 ```
 **legacy 格式** (`C:\...\RustDesk.toml`):
 ```toml
 [options]
 key = 'eYHdhv6c5+dUsaOx6EYWBSSPss6F1qtKk+18tgyURew='
 custom-rendezvous-server = '43.160.207.177'
 relay-server = '43.160.207.177'
 av1-test = 'Y'
 password = ''
 ```
 ### 6.3 写入脚本 (PowerShell)
 ```python
 import paramiko
 c = paramiko.SSHClient()
 c.set_missing_host_key_policy(paramiko.AutoAddPolicy())
 c.connect("192.168.192.67", username='Administrator', password='811223',
          look_for_keys=False, allow_agent=False, timeout=10)
 sftp = c.open_sftp()
 remote = "C:/Users/Administrator/AppData/Roaming/RustDesk/config/RustDesk2.toml"
 content = '''rendezvous_server = '43.160.207.177:21116'
 nat_type = 1
 serial = 0
 unlock_pin = ''
 trusted_devices = ''
 [options]
 custom-rendezvous-server = '43.160.207.177'
 relay-server = '43.160.207.177'
 key = 'eYHdhv6c5+dUsaOx6EYWBSSPss6F1qtKk+18tgyURew='
 local-ip-addr = '192.168.31.126'
 av1-test = 'Y'
 password = ''
 '''
 with sftp.file(remote, 'wb') as f:
    f.write(content.encode('utf-8'))
 sftp.close()
 c.close()
 ```
 ### 6.4 service 安装 + 启动
 ```cmd
 sc create rustdesk binPath= "C:\Program Files\RustDesk\rustdesk.exe --service" start= auto
 sc start rustdesk
 ```
 **注意**: `rustdesk --service` 需要 GUI session (DirectX 渲染), 不像 Linux 的 `rustdesk --service` 是 headless。Windows 上 service 跑起后会触发同用户登录的 GUI 自动拉起 (`RustDesk Tray.lnk` 在 Startup Folder)。
 ### 6.5 failure 动作配置
 ```cmd
 sc failure rustdesk reset= 5 actions= restart/5000/restart/5000/restart/5000
 ```
 **含义**: rustdesk.exe 崩溃后, 5 秒延迟, 重新启动 (重复 3 次)。
 ### 6.6 自启动验证
 ```cmd
 sc query rustdesk
 # STATE: 4 RUNNING
 # START_TYPE: 2 AUTO_START
 # 模拟 kill + auto-restart
 taskkill /F /IM rustdesk.exe
 # 等 30s
 sc query rustdesk
 # STATE: 4 RUNNING (auto-restarted)
 ```
 ### 6.7 双重自启动保护
 | 启动位置 | 状态 |
 |---|---|
 | `sc query rustdesk` START_TYPE | ✅ AUTO_START |
 | Startup Folder (`RustDesk Tray.lnk`) | ✅ 已存在 |
 | HKCU\...\Run | ❌ 不需要 (service + startup folder 已足够) |
 ---
 ## 7. 笔记本控制端 (将来 - Win11 家庭版)
 ### 7.1 下载
 ```
 https://github.com/rustdesk/rustdesk/releases/download/1.4.9/rustdesk-1.4.9-x86_64.exe
 ```
 ### 7.2 安装 (静默)
 ```cmd
 rustdesk-1.4.9-x86_64.exe --silent-install
 ```
 ### 7.3 配置 (PowerShell)
 修改 `%APPDATA%\RustDesk\config\RustDesk2.toml`:
 ```toml
 rendezvous_server = '43.160.207.177:21116'
 nat_type = 1
 serial = 0
 unlock_pin = ''
 trusted_devices = ''
 [options]
 custom-rendezvous-server = '43.160.207.177'
 relay-server = '43.160.207.177'
 key = 'eYHdhv6c5+dUsaOx6EYWBSSPss6F1qtKk+18tgyURew='
 local-ip-addr = '192.168.31.???'
 av1-test = 'Y'
 password = ''
 ```
 ### 7.4 控制 ITX
 1. 打开 RustDesk
 2. 顶部输入 `263 739 134`
 3. 弹永久密码 → 输入 `Ldw811223!`
 4. 弹新窗口 = ITX 桌面 ✅
 ---
 ## 8. 故障排除 (12 个常见坑)
 ### 8.1 Wayland 阻止 IPC 通讯
 **症状**: GUI 改 ID Server 写到 toml, 但 service 启动时 reset 回默认。
 **修复**: `WaylandEnable=false` + GDM 重启 + 选 "Ubuntu on Xorg" 登录。
 ### 8.2 rustdesk --service 启动后 reset toml
 **症状**: ssh 改了 `rendezvous_server`, 但 service 启动后看到的是 `rs-ny.rustdesk.com:21116`。
 **原因**: 1.4.9 已知, 服务启动时如果 key mismatch 自动 reset。
 **修复**:
 - 重新写 toml (key + server)
 - 删除全部 `*.toml` (清理 stale `keys_confirmed` 段)
 - 重启 service
 ### 8.3 Issue #14903 GUI 写入不持久
 **症状**: 1.4.9 GUI 在设置 Network 字段后, 重启 service 时 toml 字段被覆写。
 **原因**: rustdesk --server (ldw 用户身份) 启动时改写 user 目录 toml, 但 service 是 root 身份跑。
 **修复**:
 - 同时写两份 toml (`/root/.config/...` + `/home/ldw/.config/...`)
 - 完全删除 configs 后, service 会重新生成干净版
 ### 8.4 NAS `peer count = 0`
 **症状**: NAS hbbs log 没新事件。
 **诊断**:
 ```bash
 docker logs --tail 30 rustdesk-hbbs
 docker exec rustdesk-hbbs sh -c 'ls -la /root/'
 # 看端口监听
 ss -tnlp | grep 2111[5-7]
 ```
 ### 8.5 OpenWrt frpc TCP 21116 隧道未开
 **症状**: ITX 端 `nc -zv 43.160.207.177 21116` TIMEOUT (但 UDP 21116 succeeded)。
 **修复**: 在 `/etc/config/frp` 末尾加 `[rustdesk-tcp-21116]` 块 (见 §3.2)。
 ### 8.6 Tencent 防火墙放行失败
 **症状**: nc TCP TIMEOUT。
 **诊断**: 登 Tencent 控制台 → 防火墙 → 检查 5 条规则是否在。
 **注意**: Tencent 控制台防火墙规则**优先于** ssh iptables, 改了 iptables 不影响 Tencent 端。
 ### 8.7 toml 被覆写问题
 **症状**: ssh 写 toml → 重启 service → toml 内容被覆写。
 **原因**: rustdesk --service 启动时如果默认 server (rs-ny) 不能 verify key, 自动 reset 整个 toml。
 **修复**:
 1. 删除全部 config: `rm -rf /root/.config/rustdesk /home/ldw/.config/rustdesk`
 2. 重启 service → rustdesk 生成全新 config
 3. service 启动后立刻 ssh 写新 toml (用 reset 后的 toml 模板做基础)
 4. 再重启 service → toml 不再 reset
 ### 8.8 rustdesk 在 Windows 上 GUI 启动失败
 **症状**: rustdesk.exe 启动后立即退出, log 有 `HRESULT: 0x887A0022`。
 **原因**: GPU/DirectX 渲染失败 (这台电脑 GPU 驱动问题)。
 **修复**:
 ```cmd
 rustdesk.exe --enable-software-rendering --disable-gpu
 ```
 **注意**: 这是 GUI 启动时, 不影响 `rustdesk.exe --service` headless。
 ### 8.9 Wayland 启动 RustDesk tray 缺失
 **症状**: rustdesk 进程跑, 但任务栏没有 tray 图标, IPC 失败。
 **修复**: 同 §8.1, 切到 X11。
 ### 8.10 hbbs 启动报 `db_v2.sqlite3-shm file exists`
 **症状**: docker 启动后 hbbs 退出。
 **修复**:
 ```bash
 # 进入 NAS 目录
 cd /mnt/user/docker/rustdesk-server-aio/data/
 ls -la
 # 删除 .shm 和 .wal 文件 (SQLite 临时文件)
 rm -f db_v2.sqlite3-shm db_v2.sqlite3-wal
 # 重启 docker container
 docker restart rustdesk-hbbs
 ```
 ### 8.11 OpenWrt frpc 不重读 config
 **症状**: 改 `/var/etc/frp/frpc.conf` 后 frpc 不重载。
 **原因**: `/var/etc/frp/frpc.conf` 是 UCI 生成的, 直接编辑会被 procd 重写。
 **修复**: 改 `/etc/config/frp` + `/etc/init.d/frp restart`。
 ### 8.12 网络连通检查脚本
 ```bash
 # ITX 端
 nc -zv -w5 43.160.207.177 21115 && nc -zv -w5 43.160.207.177 21116 && nc -zv -w5 43.160.207.177 21117
 nc -zvu -w5 43.160.207.177 21116
 # NAS 端
 sqlite3 /mnt/user/docker/rustdesk-server-aio/data/db_v2.sqlite3 "SELECT count(*), id FROM peer"
 # OpenWrt 端
 ssh root@10.10.10.252 'tail -5 /var/etc/frp/frpc.log'
 ```
 ---
 ## 9. 已知限制
 1. **nas.biokingdom.top 不是这个**, 真域名是 `biokingdom.top` (43.160.207.177 是 Tencent 轻量云真实公网 IP)。
 2. **NAS 10.10.10.254 / OpenWrt 10.10.10.252 / ITX 192.168.31.14** 三者不在同一段 — 通过 zerotier (192.168.192.x) + 物理网桥通信。
 3. **Tencent frps port 5443** 是控制端口, 必须保持畅通 (frpc ↔ frps 长连接)。
 4. **rustdesk client 1.4.9 GUI 在有 GPU 问题的 Windows 上启动失败**, 用 `--disable-gpu --enable-software-rendering` 绕过 (但 service 不受影响)。
 5. **笔记本电脑首次连 ITX** 时, 必须输入 `263 739 134` + `Ldw811223!` 才能进入 ITX 桌面。
 ---
 ## 10. 变更日志
 | 日期 | 变更 | 原因 |
 |---|---|---|
 | 2026-08-05 22:20 | 初始版本 | ITX 端到端配置跑通 |
 | 2026-08-05 23:00 | 加 §3.2 OpenWrt UCI 追加 | frpc TCP 21116 隧道 |
 | 2026-08-05 23:30 | 加 §6.5 failure 动作 | 台机自启动保护 |
 | (待) | 加笔记本配置 | 笔记本 rustdesk 装好 |
 ---
 ## 11. 联系信息
 - **作者**: Robin (via Hermes agent)
 - **NAS**: 192.168.10.254 / 10.10.10.254
 - **Tencent Cloud**: 43.160.207.177
 - **自建域名**: biokingdom.top
 - **GitHub**: rustdesk/rustdesk
 ---
 ## 12. 一句话总结
 **`263739134 + Ldw811223!`** 就是 ITX 远程密钥。所有配置文件、所有 container、所有端口转发都已就位。笔记本装 rustdesk + 填 3 个字段 + 输入 9 位 ID 即可。
 ---
 ## 13. Windows 配置铁律 (2026-08-05 台机+笔记本双实战确立)
 ### ⚠️ 绝对不要用 SSH 改 toml
 RustDesk 1.4.9 在 service 启动时会**无条件**从 `RustDesk.toml` (legacy 格式) 的 `[keys_confirmed]` 段同步配置到 `RustDesk2.toml`。通过 SSH/SFTP 写入的 toml **必然被覆写**。
 **正确方法 (唯一持久化路径)**:
 1. GUI → Settings → Network → 点 Unlock
 2. 填 ID Server / Relay Server / Key
 3. 点 Apply
 4. 配置通过 IPC 写入 service，**不会被覆写**
 ### 已实测的覆写场景
 | 操作 | 结果 |
 |---|---|
 | SSH 写 RustDesk2.toml → 重启 service | ❌ 被覆写 |
 | SSH 同时写 RustDesk.toml + RustDesk2.toml | ❌ 启动几次后被覆写 |
 | SSH 写含 [keys_confirmed] 的 toml | ❌ 服务重启时随机覆写 |
 | **GUI Settings → Network → Apply** | ✅ **持久化成功** |
 ### 笔记本安装备忘
 - Win11 家庭版，用户名 `20864`
 - WSL SSH: `ldw@192.168.31.114` (WiFi, DHCP 动态), 密码 `811223`
 - Windows 有线 IP: `192.168.31.118` (静态, portproxy 到 WSL)
 - `cmd.exe` 全路径: `/mnt/c/Windows/System32/cmd.exe`
@@ -1,3 +1,10 @@
 ---
 type: "Reference"
 title: "CelVivo 销售弹药清单 (2026-07-16 实战索引)"
 description: "Sales ammunition index for CelVivo ClinoStar / ClinoReactor — price-book SKUs (ClinoReactor 12-pack, ClinoStar, SP5D-24W, Demo kit), 8-protocol SOP series (ClinoReactor prep / media change / organoid gardening / speed-tuning / alginate / VitroGel), and 5 organ-specific application cases (HepG2, FTC-133, SCLC, TNBC, ClinoStar vs Orbital Shaker). Sources from RAGFlow CelVivo KB + CelVivo commercial KB; manually curated from Robin + Hermes 实战 lessons. Used by any agent answering CelVivo ClinoReactor pricing / demo / customer-pitch queries."
 tags: [sales-ammunition, celvivo, clinoreactor, clinostar, evidence-index, 2026-08-13]
 ---
 # CelVivo 销售弹药清单 (2026-07-16 实战索引)
 > 来源: MiniMax code RAGFlow 全文检索 (CelVivo KB + CelVivo commercial KB)
@@ -1,30 +1,31 @@
 ---
 type: "Reference"
 title: "SeaFile 大文件存储索引"
 openwiki_generated: true
 ---
 # SeaFile 大文件存储索引
-> 数据源: SeaFile (http://10.10.10.254:9898/) 共 4 个资料库
+> 数据源: SeaFile (http://10.10.10.254:9898/) 共 N 个资料库
 > 用途: MiniMax code / Hermes 跨 agent 上传 / 分享 / 删除文件
 > 更新: 自动（每天 02:30 同步,sources/seafile.md 刷新）
-> 上次同步: **$(date -u +%Y-%m-%dT%H:%M:%SZ)** · ${SF_TOTAL_INFO}
+> 上次同步: **2026-08-22T18:30:01Z** · 
 ## 配置 (v1.2 skill, 2026-07-16)
 | 项目 | 值 |
 | --- | --- |
-| **API 端口** | \`9898\` (内网) — ⚠️ 5000 是 Web UI 反代, 不是 API |
+| **API 端口** | `9898` (内网) — ⚠️ 5000 是 Web UI 反代, 不是 API |
-| **API 端点** | \`http://10.10.10.254:9898/api2/\` |
+| **API 端点** | `http://10.10.10.254:9898/api2/` |
-| **公网域名** | \`https://fb.biokingdom.top\` (用于公网 share-link) |
+| **公网域名** | `https://fb.biokingdom.top` (用于公网 share-link) |
-| **Token** | \`eecfe...73c\` (40 字符, 权限齐全) |
+| **Token** | 40 字符 (权限齐全) |
-| **Auth Header** | \`Authorization: Token ***\` |
+| **Auth Header** | `Authorization: Token <token>` |
-## 4 个资料库 (实测)
+## 4-6 个资料库 (实测)
 | ID | 名称 | 大小 | 文件数 | 最后更新 | Owner |
 | --- | --- | --- | --- | --- | --- |
-|    ? | ?                    |    13.8 GB |      ? |            | Eastway Lee    |
+
 |    ? | ?                    |   615.8 MB |      ? |            | Eastway Lee    |
 |    ? | ?                    |    27.3 GB |      ? |            | Eastway Lee    |
 |    ? | ?                    |     4.1 GB |      ? |            | Eastway Lee    |
 |    ? | ?                    |          ? |      ? |            |                |
 |    ? | ?                    |          ? |      ? |            |                |
 ## 跟 LDR / Wiki.js / OpenWiki 集成
@@ -33,6 +34,6 @@
 ## 维护方式
- 自动触发: \`~/.local/bin/openwiki-update-sources.sh\` (每天 02:30)
+- 自动触发: `~/.local/bin/openwiki-update-sources.sh` (每天 02:30)
- 手动触发: \`bash ~/.local/bin/openwiki-update-sources.sh\`
+- 手动触发: `bash ~/.local/bin/openwiki-update-sources.sh`
- 数据格式: 跟 \`seafile-util\` skill 共用 (Token / 9898 port / 401 fallback)
+- 数据格式: 跟 `seafile-util` skill 共用 (Token / 9898 port / 401 fallback)
@@ -1,3 +1,10 @@
 ---
 type: "Reference"
 title: "CelVivo + Vault 实时 mtime 快照 (2026-07-16 快照)"
 description: "Historical mtime snapshot of Robin's Obsidian vault from 2026-07-16 — captures CelVivo deep-read activity (0 new entries in the 7-day window 2026-07-09 → 2026-07-16; last activity 2026-07-05), 6 entries in the 30-day window, and ClinoReactor keyword hits. Provides a baseline reference for cross-agent vault state because WSL laptop vault is not directly readable from container agents. Pre-dates the 2026-08-07 distributor refresh + 2026-08-12 Liang 2026 / 2026-08-13 Review/ subfolder activity — superseded by `/themes/05-robin-research.md` for current vault state."
 tags: [vault-snapshot, mtime, celvivo, historical-baseline, 2026-08-13]
 ---
 # CelVivo + Vault 实时 mtime 快照 (2026-07-16 快照)
 > 数据来源: WSL 直接跑 `find -mtime` 命令 (笔记本端, /mnt/c/Users/20864/.openclaw/workspace)
@@ -1,8 +1,97 @@
 ---
 type: "Reference"
 title: "Web Search Evidence"
 description: "Compact, source-backed evidence and ingestion coverage for the web-search-1 Tavily lane tracking CelVivo, 3Brain, Cellink, and related organoid news."
 tags: [source, web-search, tavily, celvivo, 3brain, cellink, organoids, 2026-08-12, 2026-08-15, 2026-08-16, 2026-08-17, 2026-08-18, 2026-08-19, 2026-08-20, 2026-08-21, 2026-08-22]
 timestamp: 2026-08-22T18:35:00Z
 ---
 # Web Search Evidence
-> Connector: `web-search-1` (Tavily). This page records compact, relevant evidence from Tavily pulls; search results are discovery leads, not vendor-confirmed announcements. Latest pull: 2026-07-27 18:04 UTC.
+> Connector: `web-search-1` (Tavily). This page records compact, relevant evidence from Tavily pulls; search results are discovery leads, not vendor-confirmed announcements. Latest successful pull: 2026-08-03 18:08 UTC. The 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, 2026-08-17, 2026-08-18, 2026-08-19, 2026-08-20, 2026-08-21, and 2026-08-22 update attempts were skipped because the connector is disabled and `TAVILY_API_KEY` is not present; no new 24-hour evidence was available on any of these ten runs.
-## 2026-07-26 pull
+## 2026-08-22 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. The nightly searxng-fallback slot (`~/.openwiki/connectors/web-search/raw/2026-08-21T18-35-04-searxng-fallback/`) is also empty (confirmed empty on disk) — no web-search evidence of any kind landed in the 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, 2026-08-17, 2026-08-18, 2026-08-19, 2026-08-20, and 2026-08-21 runs hit the same blocker; this is the **tenth consecutive skip on the same code path**. To resolve: set `TAVILY_API_KEY` in the OpenWiki runtime environment and ensure the runtime registry refreshes the connector's enabled state.
 ## 2026-08-21 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. The nightly searxng-fallback slot (`~/.openwiki/connectors/web-search/raw/2026-08-20T18-35-03-searxng-fallback/`) is also empty (confirmed empty on disk) — no web-search evidence of any kind landed in the 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, 2026-08-17, 2026-08-18, 2026-08-19, and 2026-08-20 runs hit the same blocker; the 2026-08-22 run hit the same blocker too. This was the **ninth consecutive skip on the same code path at the time of the 2026-08-21 attempt** (and the tenth skip including the 2026-08-22 follow-up). To resolve: set `TAVILY_API_KEY` in the OpenWiki runtime environment and ensure the runtime registry refreshes the connector's enabled state.
 ## 2026-08-20 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. The nightly searxng-fallback slot (`~/.openwiki/connectors/web-search/raw/2026-08-19T18-35-03-searxng-fallback/`) is also empty — no web-search evidence of any kind landed in the 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, 2026-08-17, 2026-08-18, and 2026-08-19 runs hit the same blocker; the 2026-08-21 + 2026-08-22 runs hit the same blocker too. This was the **eighth consecutive skip on the same code path at the time of the 2026-08-20 attempt** (and the tenth skip including the 2026-08-21 + 2026-08-22 follow-ups). To resolve: set `TAVILY_API_KEY` in the OpenWiki runtime environment and ensure the runtime registry refreshes the connector's enabled state.
 ## 2026-08-19 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. The nightly searxng-fallback slot (`~/.openwiki/connectors/web-search/raw/2026-08-18T18-35-03-searxng-fallback/`) is also empty — no web-search evidence of any kind landed in the 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, 2026-08-17, and 2026-08-18 runs hit the same blocker; the 2026-08-20, 2026-08-21, and 2026-08-22 runs hit the same blocker too. This was the **seventh consecutive skip on the same code path at the time of the 2026-08-19 attempt** (and the tenth skip including the 2026-08-20, 2026-08-21, and 2026-08-22 follow-ups). To resolve: set `TAVILY_API_KEY` in the OpenWiki runtime environment and ensure the runtime registry refreshes the connector's enabled state.
 ## 2026-08-18 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. The nightly searxng-fallback slot (`~/.openwiki/connectors/web-search/raw/2026-08-17T18-35-03-searxng-fallback/`) is also empty — no web-search evidence of any kind landed in the 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, and 2026-08-17 runs hit the same blocker; the 2026-08-19, 2026-08-20, 2026-08-21, and 2026-08-22 runs hit the same blocker too. This was the **sixth consecutive skip on the same code path at the time of the 2026-08-18 attempt** (and the tenth skip including the 2026-08-19, 2026-08-20, 2026-08-21, and 2026-08-22 follow-ups).
 ## 2026-08-17 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. The nightly searxng-fallback slot (`~/.openwiki/connectors/web-search/raw/2026-08-16T18-35-03-searxng-fallback/`) is also empty — no web-search evidence of any kind landed in the 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, 2026-08-12, and 2026-08-15 runs hit the same blocker; the 2026-08-18, 2026-08-19, 2026-08-20, 2026-08-21, and 2026-08-22 runs hit the same blocker too. This was the **fifth consecutive skip on the same code path at the time of the 2026-08-17 attempt** (and the tenth skip including the 2026-08-18, 2026-08-19, 2026-08-20, 2026-08-21, and 2026-08-22 follow-ups).
 ## 2026-08-15 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, and 2026-08-12 runs hit the same blocker; the 2026-08-17, 2026-08-18, 2026-08-19, 2026-08-20, 2026-08-21, and 2026-08-22 runs hit the same blocker too. This was the fourth consecutive skip on the same code path at the time of the 2026-08-15 attempt (and the tenth skip including the 2026-08-17, 2026-08-18, 2026-08-19, 2026-08-20, 2026-08-21, and 2026-08-22 follow-ups).
 ## 2026-08-12 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08 and 2026-08-10 runs hit the same blocker; this is the third consecutive skip on the same code path.
 ## 2026-08-10 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits.
 ## 2026-08-08 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 ## Historical successful pulls
 The detailed pull records below preserve the prior evidence trail in chronological order.
 ### 3D spheroid automation and assay standardization — source-backed
@@ -109,7 +198,7 @@ Third Tavily pull on the same day, after the 2026-07-27 `~/.openwiki/INSTRUCTION
 ### Coverage note for next update
 The China CDE regulatory lane is no longer being refreshed on every Tavily pull. The existing `/commitments.md` item pins it as `source-backed` with one credible cisema.com source. If a future Tavily or HN pull surfaces an NMPA / CDE-direct corroboration, promote from watchlist to `source-backed` and move into `/themes.md` as a confirmed row.
-ll
+## 2026-07-27 18:04 pull
 Fourth Tavily pull on the 2026-07-27 cycle, run as a stand-alone `openwiki personal --update` source ingest. All 10 queries were re-run. Two lanes produced genuinely new material evidence (CelVivo / ClinoReactor vendor-anchored signal; Hermes Agent v0.19 Quicksilver workflow-tooling release). One lane (3D-bioprinted-organoid reviews) added supporting evidence to the existing `class-organoid-3d-bioprinting` row. The Tavily answer-text mis-attribution pattern recurred on the 3Brain, Cellink, and MiniMax-M3 lanes — flagged again below.
@@ -172,5 +261,358 @@ All three items fold into the existing `class-organoid-3d-bioprinting` row. Last
 - Pull 2: fetched 2026-07-26T18:07:27Z — raw `~/.openwiki/connectors/web-search/raw/2026-07-26T18-07-14-335Z/web-search-results.json`
 - Pull 3: fetched 2026-07-26T18:16:21Z — raw `~/.openwiki/connectors/web-search/raw/2026-07-26T18-16-06-804Z/web-search-results.json`
 - Pull 4: fetched 2026-07-27T18:04:46Z — raw `~/.openwiki/connectors/web-search/raw/2026-07-27T18-04-01-259Z/web-search-results.json`
- Queries: pulls 1, 2, 4 = 10 queries each; pull 3 = 6 queries (vendor-anchored only)
+- Pull 5: fetched 2026-07-28T18:04:26Z — raw `~/.openwiki/connectors/web-search/raw/2026-07-28T18-03-43-560Z/web-search-results.json`
 - Queries: pulls 1, 2, 4, 5 = 10 queries each; pull 3 = 6 queries (vendor-anchored only)
 - Instance: `web-search-1`
 ---
 ## 2026-07-28 18:04 pull
 Fifth Tavily pull, run as a stand-alone `openwiki personal --update` source ingest. All 10 queries re-run. Two lanes produced genuinely new material evidence (China Order No. 818 regulatory shift; LLM Wiki + OKF shared-memory architecture cluster). The China CDE classification item, CelVivo/TheWell partnership, and Hermes v0.19 Quicksilver rows were not re-anchored in this pull — they remain pinned via `/commitments.md` and the `hermes-agent-v0-19-quicksilver` / `china-cde-cell-gene-therapy-rules-2026` theme rows. Tavily answer-text mis-attribution continues on the 3Brain, Cellink, and Hermes lanes.
 ### China Order No. 818 — accelerated clinical-translation pathway — source-backed
 This is a **new Chinese regulatory signal distinct from the existing CDE classification item**. Order No. 818 (effective 2026-05-01) creates an accelerated pathway for advanced biomedical technologies — including cell therapy and 3D bioprinting — to reach clinical translation at qualified hospitals after demonstrating safety and preliminary efficacy.
 - **LinkedIn (BetaLife SG), 2026-07:** [#ipsc #betalife #celltherapy #ipsc #regenerativemedicine #diabetes #clinicaltranslation #biotechnology #xiamen](https://www.linkedin.com/posts/betalife-sg_betalife-celltherapy-ipsc-activity-7487455334345834497-5hKR). Score 0.779. Explicitly references "Order No. 818, effective May 1, 2026. The regulation introduces an accelerated pathway for eligible advanced biomedical technologies towards regulated clinical translation at qualified hospitals after demonstrating safety and preliminary efficacy." BetaLife (a Singapore-based iPSC company) names this in their post; they cite it as directly relevant to their China clinical-translation journey.
 - **Roots Analysis, 2026-07:** [Cell Therapy Manufacturing Market Size 2035](https://www.rootsanalysis.com/reports/cell-therapy-manufacturing/285.html). Score 0.669. Re-mention of the broader China cell-therapy regulatory landscape (Merck–Bio-Techne $11.3B acquisition, CARsgen China approval). Not an Order No. 818 citation directly, but corroborates the pattern of accelerating China cell-therapy regulatory activity in the same window.
 - **Tavily answer text** independently synthesizes: "China's regulation under Order No. 818, effective May 1, 2026, introduces an accelerated pathway for advanced biomedical technologies, including cell therapy and 3D bioprinting, towards clinical translation at qualified hospitals after demonstrating safety and preliminary efficacy." This is the same content as the BetaLife post — single primary source, with Tavily's synthesis echoing it.
 **Robin relevance:** HIGH for the Chinese pharma R&D / CDMO / biotech customer base. Order No. 818 is the **clinical-translation pathway** counterpart to the CDE classification item (which is about CMC planning). Both items matter: classification scope drives what dossier content vendors need to assemble, and the clinical-translation pathway drives which hospitals can host the first-in-human studies. Together they shape how Femtobiomed positions CelVivo-class bioreactors and 3Brain-class MEA platforms into Chinese accounts.
 **Why source-backed (not watchlist):** the item is published regulatory text (Order No. 818, effective 2026-05-01), not a rumor; BetaLife is a credible industry-actor source citing it in their own clinical-translation context; the Tavily synthesis is consistent with the BetaLife wording. Treat as source-backed pending direct NMPA / State Council corroboration. **Promoted** to `/themes.md` as a new row `china-order-no-818-clinical-translation` and to `/commitments.md` as a verification item.
 ### LLM Wiki + OKF / shared-agent-memory cluster — source-backed (workflow tooling, low priority)
 The `agent personal memory wiki 2026` query returned five same-week sources on a single coherent architecture: a shared agent-memory layer using Andrej Karpathy's LLM Wiki + Google's Open Knowledge Format (OKF) + Model Context Protocol (MCP), positioned to let "every Local AI … share ONE permanent memory." This is directly adjacent to OpenWiki's role.
 - **YouTube (Kai), 2026-07-23:** [LLM Wiki + OKF Every Local AI Now Shares ONE Memory](https://www.youtube.com/watch?v=9ciGYHHOLyU). Score 0.752. Walkthrough of the LLM Wiki + OKF + MCP stack for cross-agent shared memory without vector databases.
 - **Taskade AI, 2026-07:** [The 4 Types of AI Agent Memory Explained (2026)](https://www.taskade.com/wiki/ai-agents/memory-types). Score 0.705. Taskade's own memory architecture (long-term / episodic / short-term / semantic) framed in the same shared-memory terms.
 - **GitHub (SamurAIGPT), 2026-07:** [SamurAIGPT/llm-wiki-agent](https://github.com/SamurAIGPT/llm-wiki-agent). Score 0.694. Open-source "personal knowledge base that builds and maintains itself" — wiki-ingest / wiki-query primitives that mirror Robin's OpenWiki mental model.
 - **LinkedIn (David Bressler, PhD), 2026-07:** [Personal wikis, LLM-maintained knowledge bases, and agent memory systems all eventually hit the same question: How do you know the information in there is still accurate?](https://www.linkedin.com/posts/david-bressler_personal-wikis-llm-maintained-knowledge-activity-7486993623939678208-q4rL). Score 0.614. Adjacent commentary on knowledge-base freshness in agent-maintained wikis.
 - **Reddit r/ClaudeAI, 2026-07-23:** [How many of you are running an LLM wiki with claude code?](https://www.reddit.com/r/ClaudeAI/comments/1v4rdiv/how_many_of_you_are_running_an_llm_wiki_with). Score 0.288 (31 upvotes, 26 comments). Community confirmation that OKF-formatted Obsidian wikis are a working pattern for Claude Code users.
 - **BigDATAwire (Exabase), 2026-07-28:** [Exabase Reports State-of-the-Art Results on BEAM Memory Benchmark](https://www.hpcwire.com/bigdatawire/this-just-in/exabase-reports-state-of-the-art-results-on-beam-memory-benchmark). Score 0.567. Adjacent: BEAM-style memory benchmarks for agent memory engines.
 **Robin relevance:** workflow-tooling, low priority — but the cluster is **substantially more corroborated than the prior HN-only signal**. Five distinct publishers (YouTube creator, SaaS vendor, GitHub, LinkedIn, Reddit) and one adjacent benchmark in the same week all converge on the same OKF + MCP shared-memory architecture. Combined with the existing `agent-memory-architecture` row's three HN Show HN items, the topic now has 8+ distinct sources. **Promote** `agent-memory-architecture` from `watchlist` to `source-backed` and refresh Last seen to 2026-07-28.
 ### 3Brain / Cellink / CellShot / installed-base / Hermes lanes — no new vendor-anchored evidence; Tavily answer-text mis-attribution recurs
 - **3Brain CorePlate MEA 2026:** the Nature [portable semi-dry EEG device paper](https://www.nature.com/articles/s41598-026-52672-8) reappears at score 0.187. Tavily answer text again labels it "3Brain CorePlate MEA 2026 validated in a brain–computer interface study" — the underlying paper is about a portable EEG headset, **not 3Brain's MEA chips**. This is the fourth pull in a row with the same mis-attribution. Do not promote as 3Brain evidence.
 - **Cellink BIO X bioprinter 2026:** Tavily answer text labels the Roche [ADLM 2026 intelligent lab solutions press release](https://www.biospace.com/press-releases/roche-showcases-intelligent-lab-solutions-and-high-precision-instruments-at-adlm-2026-to-help-laboratories-address-workforce-and-workflow-challenges) (0.082) as "Cellink BIO X bioprinter at ADLM 2026" — the underlying source is Roche, not Cellink. The remainder of the lane is industry context (Nova Biomedical–NanoCellect, Massive Bio–GELL, Lumafield Mars X-ray, Repligen–BioLife, BioTechniques bi-weekly). All unrelated to Cellink BIO X / BIONOVA X / Lumen X.
 - **CellShot / CellPick bioprinter 2026:** Tavily honestly says "the CellShot CellPick bioprinter 2026 is not directly mentioned in the provided data sources." Top hits are CCDx whole-cell genomic profiling (0.164), Nova Biomedical–NanoCellect (0.062), AI protein engineering model (0.059), Towards Healthcare cell-and-gene-therapy intelligence infrastructure (0.052), Pluristyx re-mention (0.042). No Femtobiomed vendor signal.
 - **labs CelVivo ClinoStar installed base 2026:** no direct result. Cepheid GeneXpert third-generation ADLM 2026 (score 0.112) and Roche ADLM 2026 (0.143) dominate the top slots and are unrelated to CelVivo installed-base. Query phrasing continues to drift toward competitor/molecular-diagnostic content.
 - **Hermes Agent MiniMax M3 changelog 2026:** Tavily answer text returns Apple product news ("Mismatched M6 and M5 Pro chips", iOS 26.6, POCO Launcher 7.50) — no Hermes Agent, no MiniMax M3, no Hermes changelog in the underlying URLs. Top hit: [MacRumors Next Mac Mini article](https://www.macrumors.com/2026/07/22/mac-mini-m6-m5-pro-chips-rumor/) at 0.074. The v0.19 Quicksilver signal from the prior pull remains the most recent Hermes row; this lane produced nothing new in this 24h window.
 - **OpenWiki connectors Tavily RAGFlow 2026:** Tavily recall still broken. Returns AWWA ACE26 SmartBall X (0.025), Bizora advisory group / Billtrust MCP server (0.026), OpenTug shipping (0.017), Sunvega AI spatial-design workspace (0.016), RightShip maritime (0.016), Inland Tank-Barge Safety Guide (0.015). Only the Billtrust MCP server item is mildly adjacent (MCP-server ecosystem); the rest is unrelated to OpenWiki / Gitea / Wiki.js / RAGFlow / NocoDB / SeaFile. Recommend dropping this lane from future Tavily runs unless the query is rephrased to anchor on product names.
 - **organ-on-chip pharma collaboration 2026:** the Nature [Gut-on-a-Chip culturomics paper](https://www.nature.com/articles/s44385-026-00099-1) (0.986) is the same item surfaced in the 2026-07-26 17:39 pull. Application-domain signal only — folds into the `class-organoid-3d-bioprinting` row without a new evidence note.
 ### Synthesis result
 - **Two new scope-aligned findings:**
  1. **China Order No. 818** — clinical-translation pathway for cell therapy + 3D bioprinting at qualified hospitals, effective 2026-05-01. Source-backed on a single primary source (BetaLife LinkedIn) with Tavily synthesis corroboration. Distinct from the existing `china-cde-cell-gene-therapy-rules-2026` item (classification vs clinical pathway). Promoted to `/themes.md` as new row `china-order-no-818-clinical-translation` and to `/commitments.md` as a verification item.
  2. **LLM Wiki + OKF shared-memory cluster** — five Tavily sources + three prior HN sources all converge on Karpathy's LLM Wiki + Google OKF + MCP shared-memory architecture. Directly adjacent to OpenWiki's role. Promotes existing `agent-memory-architecture` row from `watchlist` to `source-backed`.
 - **No new vendor-anchored evidence** on CelVivo, 3Brain, Cellink, CellShot/TriArm, or Hermes this pull. The prior vendor-anchored items (CelVivo+TheWell, Hermes v0.19 Quicksilver) remain on disk and referenceable; the Hermes row's Last seen is **not** refreshed because the underlying URLs in this pull returned Apple-product noise.
 - **Tavily answer-text mis-attribution pattern persists** on 3Brain (4th pull), Cellink (4th pull), and Hermes (1st pull). This is a Tavily-side quality issue; treat Tavily answer text as untrusted and only the underlying URLs as evidence. Continued recommendation: narrow future pulls to vendor-name-anchored queries only.
 - **OpenWiki / RAGFlow / agent-memory lane behavior changed.** The lane still produces zero OpenWiki/RAGFlow/SeaFile/NocoDB/Gitea results, but the **agent-personal-memory-wiki** lane is now high-signal for the OKF/LLM Wiki architecture — strong enough to promote the existing `agent-memory-architecture` row.
 ---
 ## 2026-07-29 18:03 pull
 Sixth Tavily pull, run as a stand-alone `openwiki personal --update` source ingest. All 10 queries re-run. Three lanes produced material new evidence: Cellink BIO X Gen 3 first-time vendor-anchored signal; China CGT regulatory landscape material updates (Merck–Bio-Techne, CARsgen satri-cel, gene-editing trial death + backlash); Hermes Agent v0.19 documentation continues (configuration.md, api-server.md). The CelVivo/TheWell xeno-free and China Order No. 818 items remain pinned in `/commitments.md`. The agent-memory-architecture cluster continues to grow. Tavily answer-text mis-attribution persists on Q2/Q3 (3Brain / Cellink) but the underlying URLs are now vendor-anchored for Cellink — a first.
 ### Cellink BIO X Gen 3 / BIO X6 — first vendor-anchored Cellink signal — source-backed
 This is the **first vendor-anchored Cellink BIO X / BIO X6 / BIO X Gen 3 signal in any Tavily pull**. Prior pulls returned only MO:BOT, Roche, Cepheid, Velo3D, Cellares-Papillon, or generic bioprinting market reports — never Cellink product names in a vendor/customer context. Three same-week sources confirm Cellink product activity:
 - **LinkedIn (Nuclear Mechano-Oncology), no exact date in 2026-07:** [BIO X Gen 3 Bioprinter Installed and Trained](https://www.linkedin.com/posts/nuclear-mechano-oncology_exciting-news-from-our-lab-our-new-bio-activity-7486350933371543552-CBoV). Score 0.601. A customer lab (Nuclear Mechano-Oncology) announces the install + first hands-on training of a BIO X Gen 3 bioprinter, with team members Ines Papak, Kamil Łangowski, Julia Jała named. Positions BIO X Gen 3 as "an important addition to our work on advanced 3D cell culture models and the development of more physiologically relevant cancer research platforms."
 - **LinkedIn (CELLINK official channel), 2026-07-28:** [From Star Trek to the Clinic: 3D Bioprinting Facility is Engineering Molecules for Patient Implantation](https://www.linkedin.com/posts/cellink_from-star-trek-to-the-clinic-3d-bioprinting-activity-7487839428997046272-myqA). Score 0.287. CELLINK's own organization page (26,186 followers) highlights the University of Miami 3D Bioprinting Facility using CELLINK's BIO X6 in the toolkit for tissue engineering and patient-specific implants. Companion article from InventUM.
 - **LinkedIn (Biomedical 3D Printer Market report), 2026-07-28:** [Biomedical 3D Printer Market Size and Growth at a 4.7% CAGR from 2026 to 2033](https://www.linkedin.com/pulse/biomedical-3d-printer-market-size-growth-47-bstsf). Score 0.659. Third-party market report explicitly names Cellink as a major player with "a significant uptick in their revenue stream" following "strategic acquisitions and increased market penetration" and notes Cellink's "focus on sustainable and customizable bioinks."
 - **apellaser.ro, 2026-07-24:** [How to Choose a 3D Bioprinter: Practical Selection Guide](https://apellaser.ro/en/bioprinter-selection-guide). Score 0.303. Independent practical guide explicitly names "BIO X Gen 3 is the general-purpose choice for laboratories that need flexible extrusion and up to three interchangeable printheads or tools." Vendor-anchored reference, not a press release.
 - **Tavily answer text** describes "The Cellink BIO X bioprinter, specifically the Gen 3 model, is a versatile tool for laboratories requiring flexible extrusion and up to three interchangeable printheads" — this time the answer text correctly identifies Cellink product naming (though it includes hallucinated "Gen 3" details in some phrases; the underlying URLs are the source of truth).
 **Robin relevance:** HIGH. First vendor-anchored Cellink signal after 5 prior pulls of zero Cellink product mentions. The Nuclear Mechano-Oncology install is an Eastern European customer reference; the U. Miami BIO X6 mention is the same University of Miami 3D Bioprinting Facility that has been a recurring Cellink reference in industry press; the market report independently corroborates Cellink revenue growth. Promoted to `/commitments.md` as `cellink-bio-x-gen3-customer-evidence` for next-vendor-check verification (parallel structure to the CelVivo+TheWell row).
 ### China cell & gene therapy regulatory landscape — material updates — source-backed
 The Q7 lane surfaced four distinct new items that materially update the existing `/commitments.md` `china-cde-cell-gene-therapy-rules-2026` and `china-order-no-818-clinical-translation` items. The gene-editing trial death + regulatory backlash is the most consequential — it directly affects how Robin positions 3Brain MEA + CelVivo ClinoReactor + Cellink BIO X for Chinese pharma R&D / CDMO / biotech customers.
 - **Roots Analysis, 2026-07-24:** [Cell Therapy Manufacturing Market Size 2035](https://www.rootsanalysis.com/reports/cell-therapy-manufacturing/285.html). Score 0.669. Two new data points from the same Roots Analysis page: (a) **June 2026: Merck agreed to acquire Bio-Techne for ~$11.3B** to strengthen life-science capabilities across bioprocessing, advanced therapeutics, and integrated workflow solutions for cell-and-gene-therapy developers; (b) **June 2026: CARsgen Therapeutics received China NMPA approval for satri-cel, a CAR-T therapy for solid-tumor stomach cancer** — described as "an important milestone for solid tumor CAR-T therapies" expected to increase demand for specialized CAR-T manufacturing in Asia-Pacific.
 - **BioSpace, 2026-07-27:** [Summit, Merck must navigate new regulatory terrain in China-first cancer landscape](https://www.biospace.com/drug-development/summit-merck-must-navigate-new-regulatory-terrain-in-china-first-cancer-landscape). Score 0.535. Frames the broader pattern of China-first cancer-drug development: Stifel analysts (2026-07-22 note) argue the HARMONi 2-year follow-up data is "a strong counter" to the "China data would not translate" bear argument. Implications for CDMO and instrument vendors supporting both Western and China-first pipelines.
 - **Straits Times, 2026-07-24:** [Patient death in China gene-editing trial draws fire: Journal](https://www.straitstimes.com/asia/east-asia/patient-death-in-china-gene-editing-trial-draws-fire-journal). Score 0.313. A patient (later confirmed as a 6-year-old girl in follow-up coverage) died in an experimental gene-editing trial in China; the case is drawing published scrutiny of China's gene-therapy regulatory regime.
 - **LiveScience, 2026-07-24:** [An experimental gene therapy killed a 6-year-old girl in China. Her parents are seeking accountability](https://www.livescience.com/health/genetics/6-year-old-in-china-dies-after-experimental-treatment-investigation-finds-raising-questions-about-the-countrys-gene-therapy-regulations). Score 0.145. Investigation-level coverage: raises "questions about the country's gene therapy regulations."
 - **SCMP, 2026-07-29:** [Is China's biotech boom at risk? Fear of policy backlash after death in gene-editing trial](https://amp.scmp.com/news/china/science/article/3362253/chinas-biotech-boom-risk-fear-policy-backlash-after-death-gene-editing-trial). Score 0.203. Frames the same death as a potential inflection point for China's biotech regulatory regime — "Fear of policy backlash." Published same day as this Tavily pull, which is what surfaces it.
 **Robin relevance:** HIGH (the gene-editing trial death item especially). The Merck–Bio-Techne acquisition and CARsgen satri-cel approval are positive indicators of the China CGT manufacturing environment. The gene-editing trial death + published regulatory scrutiny is the inverse signal: it could foreshadow stricter CDE / NMPA / hospital-level oversight, which would affect (a) qualification timelines for the CellShot-TriArm and ClinoReactor-class deals Robin has in flight, and (b) which "qualified hospitals" under Order No. 818 remain eligible. Promoted to `/commitments.md` as `china-cgt-2026-july-developments` to track this as a single follow-up item.
 ### Organ-on-chip pharma collaboration 2026 — source-backed (application-domain)
 The Q4 lane returned two strong same-week items on organ-on-chip / pharma collaboration:
 - **Business Weekly, 2026-07-24:** [Business Weekly Awards 2026: 44 shortlisted companies revealed for Cambridge Tech and Life Sciences showcase](https://www.businessweekly.co.uk/posts/business-weekly-awards-2026-44-shortlisted-companies-revealed-for-cambridge-tech-and-life). Score 0.754. **CN Bio** (Chesterford Research Park) shortlisted for the OOC PhysioMimix platform; profile explicitly cites a **$11m funding deal with Ligand Pharmaceuticals (Florida)** and a **co-development agreement with Sequel Med Tech LLC (New Hampshire)** as last-year's announcements.
 - **SelectScience, 2026-07-28:** [Organ-Chips reach new frontiers with NASA's AVATAR project and next-gen preclinical testing](https://www.selectscience.net/article/organ-chips-reach-new-frontiers-with-avatar-and-next-gen-preclinical-testing). Score 0.736. NASA AVATAR (A Virtual Astronaut Tissue Analog Response) project uses OOC devices to study deep-space effects on human health; features Emulate's 96-chip AVA Emulation System helping pharma transition to human-relevant testing under FDA Modernization Act 2.0 / UK guidelines.
 - **Nature, 2026-07-24:** [Engineering human Gut-on-a-Chip culturomics](https://www.nature.com/articles/s44385-026-00099-1) reappears at score 0.367 (re-mention from pulls 1 + 5).
 **Robin relevance:** application-domain only — folds into the existing `class-organoid-3d-bioprinting` row. CN Bio / Emulate are not one of Robin's 4 vendor lines, but both are competitive/positioning signal for CelVivo-class bioreactors at pharma R&D accounts. NASA AVATAR is a high-visibility OOC application milestone.
 ### Hermes Agent v0.19 documentation refresh — source-backed (workflow tooling, low priority)
 Q8 returned two NousResearch/hermes-agent repo documentation updates and one third-party M3-vs-OpenClaw comparison. The docs confirm v0.19+ work is still landing in the 2026-07-26 → 2026-07-29 window — same row as the v0.19 Quicksilver signal, more sources.
 - **GitHub (NousResearch/hermes-agent `configuration.md`), 2026-07-26:** [Iteration Budget](https://github.com/NousResearch/hermes-agent/blob/main/website/docs/user-guide/configuration.md). Score 0.590. Documents the iteration-budget behavior change: "earlier builds warned the model at 70%/90% budget, which caused models to abandon complex tasks prematurely and was removed in April 2026." Now at default 500 turns, Hermes injects one wrap-up message at 500/500 with a single grace call. Story-worthy because it is a deliberate quality change, not just a number.
 - **GitHub (NousResearch/hermes-agent `features/api-server.md`), 2026-07-27:** [POST /v1/runs/{run_id}/stop + /approval endpoints](https://github.com/NousResearch/hermes-agent/blob/main/website/docs/user-guide/features/api-server.md). Score 0.367. Documents the new `/v1/runs/{run_id}/stop` and `/v1/runs/{run_id}/approval` endpoints (returning `{"status": "stopping"}` and resolving approval policies). Sample JSON now uses `"model":"MiniMax-M3"` with provider `"minimax"` — M3 is the documented default.
 - **MyClaw.ai, 2026-07-29:** [OpenClaw vs MiniMax Agent: Which AI Agent Should You Use in 2026?](https://myclaw.ai/blog/openclaw-vs-minimax-agent). Score 0.543. Third-party comparison: **OpenClaw supports MiniMax through OAuth with a Token Plan or API key.** M3 handles primary reasoning; M2.7 variants remain available. Multimodal (image, video, music, speech, web search) supported across M3 and M2.7.
 - **Instagram (Sriram Varadharajan), no exact date in 2026-07:** [AI COMMAND CENTER TRIAL REEL — MiniMax M3 announcement](https://www.instagram.com/reel/DbVydtNj46Z). Score 0.497. Reels text references MiniMax M3 launch ("longer context, capability uplift over M2") and open-source readiness. Adjacent to MiniMax-M3 theme row.
 **Robin relevance:** WORKFLOW TOOLING (low priority). The configuration.md change is a Hermes-side behavior update Robin's daily-driver stack benefits from; the api-server.md endpoints are runtime-control surfaces OpenWiki's MCP integration could exploit; MyClaw.ai confirms MiniMax M3 as the operational model for both OpenClaw and Hermes. Folded into the existing `hermes-agent-v0-19-quicksilver` and `MiniMax-m3` theme rows — refreshes Last seen but does not spawn a new row.
 ### Agent-memory-architecture cluster grows — source-backed (workflow tooling, low priority)
 Q10 returned four new sources that further corroborate the existing `agent-memory-architecture` theme row. Combined with the prior 5 Tavily + 3 HN sources, the cluster now has 12+ distinct publishers converging on shared / open-format / persistent agent-memory architectures:
 - **HPCwire, 2026-07-28:** [Exabase Reports State-of-the-Art Results on BEAM Memory Benchmark](https://www.hpcwire.com/aiwire/2026/07/28/exabase-reports-state-of-the-art-results-on-beam-memory-benchmark). Score 0.624. Exabase M-1 achieves highest reported score at every scale: **76.9% at 100K tokens, 75.0% at 1M tokens, 68.0% at 10M tokens**, using Gemini 3 Flash (a model "up to six times cheaper and faster" than Gemini 3 Pro used by every other leading system). 20% fewer tokens per query than next-best system.
 - **Hackernoon (Moorcheh.ai CTO), 2026-07-28:** [Agent Memory Has a Lock-In Problem. Open Formats Are How We Fix It.](https://hackernoon.com/agent-memory-has-a-lock-in-problem-open-formats-are-how-we-fix-it). Score 0.605. Frames the lock-in problem explicitly: "Your agent has been in production for a year. … thousands of memories: user preferences, resolved decisions, corrections, domain facts. Now you want to move to a different memory system — better retrieval, better pricing, whatever. What's your migration path?" Argues for **Diffability** ("`git diff` shows exactly what your agent learned between two commits"), **Reviewability** ("Memory changes can go through pull requests like code"), and **Auditability** ("Regulated environment? Your …"). This is the most explicit OpenWiki-aligning post yet — pull-request review of agent memory is exactly what OpenWiki's synthesis workflow does.
 - **Towards Data Science, 2026-07-24:** [Context Windows Forget What Matters — I Built a Usage-Reinforced Decay Engine for AI Agent Memory](https://towardsdatascience.com/context-windows-forget-what-matters-i-used-a-140-year-old-psychology-paper-to-fix-ai-memory). Score 0.576. Uses Ebbinghaus forgetting curve (1885) to design a spaced-repetition decay engine for agent memory. Cites the open-source **YourMemory** project (Mishra, 2026) as another Ebbinghaus-forgetting-curve implementation. Robin-relevant because OpenWiki's wiki synthesis itself is a form of spaced-repetition knowledge curation.
 - **The Register, 2026-07-29:** [MinIO pitches persistent memory for agents with work to finish](https://www.theregister.com/storage/2026/07/29/minio-pitches-persistent-memory-for-agents-with-work-to-finish/5280407). Score 0.425. MinIO **AIStor Memory** for long-running multi-step agent workflows. Example use cases: software engineering agents across large codebases; deep research spanning hours or days; human-in-the-loop workflows that pause and resume; enterprise AI systems handling regulated data. The piece argues "agent-generated work accumulates, memory created for individual agents can become a shared organizational record built by humans and machines" — and that where that record lives is the architectural question OpenWiki sits at.
 **Robin relevance:** WORKFLOW TOOLING (low priority). The cluster is now 12+ sources. The Hackernoon/Moorcheh.ai piece is the strongest single source for OpenWiki alignment (pull-request review of agent memory maps 1:1 onto OpenWiki's synthesis). The MinIO piece confirms enterprise infrastructure vendors are now treating "shared organizational memory built by humans and machines" as a product category. Refreshes `agent-memory-architecture` Last seen to 2026-07-29 and adds to evidence count.
 ### 3Brain / CellShot / installed-base / OpenWiki-RAGFlow / Tavily answer-text quality — same pattern
 - **3Brain CorePlate MEA 2026:** Nature [portable semi-dry EEG device paper](https://www.nature.com/articles/s41598-026-52672-8) reappears at score 0.187 — **fifth pull in a row with the same mis-attribution**. Tavily answer text again labels it "3Brain CorePlate MEA 2026 … validated for its application in brain–computer interface solutions." Underlying paper is a portable EEG headset, not 3Brain MEA chips. Do not promote as 3Brain evidence.
 - **Cellink BIO X bioprinter 2026:** as noted above, this pull is the first to return real Cellink product evidence. Tavily answer text was finally correct on the Cellink side this time ("Cellink BIO X bioprinter, specifically the Gen 3 model, is a versatile tool for laboratories requiring flexible extrusion and up to three interchangeable printheads").
 - **CellShot / CellPick bioprinter 2026:** Tavily honestly says "The CellShot CellPick bioprinter 2026 is not mentioned in the provided data sources." Top hit is **GEN "Large Bioprinted Tissues Get a Precision Boost"** (2026-07-29 12:00:52 GMT, score 0.259) — application-domain news, no Femtobiomed vendor signal. The same GEN article reappears in Q1 (0.037), Q2 (0.032), and Q5 (0.259). Worth a note in `class-organoid-3d-bioprinting` evidence column.
 - **labs CelVivo ClinoStar installed base 2026:** Tavily answer text returns a hallucinated claim: "As of today, July 29, 2026, the CelVivo ClinoStar is being installed in new A-Level (H2) science labs, such as the one opening in Eclat @ Henderson in August 2026." **No URL in the result set mentions CelVivo, ClinoStar, A-Level, H2, Eclat, or Henderson.** This is a fabricated Tavily answer — flag and ignore. The actual top hits are Instagram reels and the UFS Alzheimer's story, all unrelated to CelVivo.
 - **Hermes Agent MiniMax M3 changelog 2026:** as noted above — first pull with non-noise Hermes/M3 evidence (configuration.md, api-server.md, MyClaw.ai, Instagram reel). Promotes the existing rows instead of spawning new ones.
 - **OpenWiki connectors Tavily RAGFlow 2026:** recall still broken. Returns Roche ADLM 2026 (0.043), Nature chemical-reaction pathway algorithm (0.029), SmartBall X water infrastructure (0.025), exposure-management AI-attack cybersecurity (0.023), HID workforce unit transfer (0.019), **GEN "Downstream Purification Platform Breaks Complex Vector Bottleneck"** (0.017), RightShip maritime (0.016), insurance payment (0.016). Only the GEN vector-bottleneck item is mildly adjacent (cell-and-gene-therapy manufacturing); the rest is noise. Recommend dropping this lane from future Tavily runs.
 ### Synthesis result
 - **Three new scope-aligned findings:**
  1. **Cellink BIO X Gen 3 / BIO X6 customer evidence** — first vendor-anchored Cellink signal in any Tavily pull. Multi-source (Nuclear Mechano-Oncology LinkedIn install, CELLINK official LinkedIn BIO X6 at U. Miami, third-party market report, appellaser selection guide). Promoted to `/commitments.md` as `cellink-bio-x-gen3-customer-evidence`.
  2. **China CGT regulatory landscape updates** — Merck–Bio-Techne $11.3B acquisition (June 2026); CARsgen satri-cel CAR-T approval for stomach cancer (June 2026); **gene-editing trial death + regulatory backlash** (Straits Times / LiveScience / SCMP coverage 2026-07-24 → 2026-07-29). Promoted to `/commitments.md` as `china-cgt-2026-july-developments` to track the gene-editing-death + China-biotech-backlash signal alongside the existing classification and Order No. 818 items.
  3. **Hermes Agent v0.19 docs continue** — `configuration.md` iteration-budget behavior change (April 2026, documented 2026-07-26) + `api-server.md` new stop / approval endpoints (2026-07-27). Refreshes Last seen for `hermes-agent-v0-19-quicksilver`. MyClaw.ai confirms MiniMax M3 + M2.7 as the operational models for both OpenClaw and Hermes — refreshes Last seen for `MiniMax-m3`.
 - **One application-domain cluster strengthens:** organ-on-chip (CN Bio + Ligand + Sequel Med Tech; NASA AVATAR + Emulate). Folds into the existing `class-organoid-3d-bioprinting` row without spawning a new theme.
 - **Agent-memory-architecture cluster grows to 12+ distinct sources.** Hackernoon/Moorcheh.ai "Agent Memory Has a Lock-In Problem" is the strongest single OpenWiki-aligning source yet. Refreshes Last seen for `agent-memory-architecture`.
 - **Tavily answer-text mis-attribution continues** on Q2 3Brain (5th pull). This is now a Tavily-side quality issue worth flagging in connector notes.
 - **New Tavily hallucination pattern on Q6:** the Tavily answer text invented a specific claim about CelVivo ClinoStar being installed in "new A-Level (H2) science labs, such as the one opening in Eclat @ Henderson in August 2026." No underlying URL supports this. Treat Tavily answer text on the installed-base query as fabrication and ignore.
 - **No 3Brain / CellShot-TriArm / OpenWiki-RAGFlow direct evidence** in this pull.
 ## Source coverage (cumulative)
 - Pull 1: fetched 2026-07-26T17:39:11Z — raw `~/.openwiki/connectors/web-search/raw/2026-07-26T17-38-33-286Z/web-search-results.json`
 - Pull 2: fetched 2026-07-26T18:07:27Z — raw `~/.openwiki/connectors/web-search/raw/2026-07-26T18-07-14-335Z/web-search-results.json`
 - Pull 3: fetched 2026-07-26T18:16:21Z — raw `~/.openwiki/connectors/web-search/raw/2026-07-26T18-16-06-804Z/web-search-results.json`
 - Pull 4: fetched 2026-07-27T18:04:46Z — raw `~/.openwiki/connectors/web-search/raw/2026-07-27T18-04-01-259Z/web-search-results.json`
 - Pull 5: fetched 2026-07-28T18:04:26Z — raw `~/.openwiki/connectors/web-search/raw/2026-07-28T18-03-43-560Z/web-search-results.json`
 - Pull 6: fetched 2026-07-29T18:03:26Z — raw `~/.openwiki/connectors/web-search/raw/2026-07-29T18-02-29-119Z/web-search-results.json`
 - Pull 7: fetched 2026-07-30T18:04:41Z — raw `~/.openwiki/connectors/web-search/raw/2026-07-30T18-03-34-547Z/web-search-results.json`
 - Queries: pulls 1, 2, 4, 5, 6, 7 = 10 queries each; pull 3 = 6 queries (vendor-anchored only)
 - Instance: `web-search-1`
 ---
 ## 2026-07-30 18:04 pull
 Seventh stand-alone Tavily pull; all 10 queries re-ran. The material additions are the first credible direct 3Brain result in this lane, lower-confidence CelVivo ClinoStar campaign snippets, authoritative FDA organ-on-chip/NAMs context, and continued Hermes/OpenWiki/agent-memory evidence. Cellink, CellShot, and China-policy results were predominantly re-mentions or attribution noise.
 ### 3Brain CorePlate conference and application positioning — confirmed vendor signal
 - **3Brain organization material via LinkedIn, surfaced with a 2026-07-25 result:** [ISSCR 2026 / CorePlate-enabled HD-MEA campaign](https://www.linkedin.com/posts/lucyschmidt_neuroscience-cellbiology-brain-activity-7486837823321292800-F8Rk) (score 0.857) positions CorePlate for high-resolution, scalable functional readouts from iPSC-derived neuronal models, brain organoids, assembloids, and neuronal/cardiomyocyte screens; it names ISSCR booth 412.
 - **3Brain company LinkedIn:** [3Brain AG](https://jp.linkedin.com/company/3brain) (score 0.839) adds ELRIG Drug Discovery booth 4 and describes multi-well HD-MEA use for mechanistic studies and higher-throughput screening across neuronal/cardiac models, 3D spheroids, and brain organoids. The page aggregates multiple posts, so individual event timing still needs a direct vendor check.
 - **3Brain official site:** [High-Density Microelectrode Array](https://www.3brain.com) (score 0.689) independently anchors CorePlate 3D / Accura-3D, brain-organoid and Pharma-on-Chip applications, and BrainWave 6. The pull contains no new CorePlate load-force, Sample Holder Set, or patent detail.
 - **Robin relevance:** first credible direct 3Brain evidence after five pulls dominated by an unrelated EEG-paper mis-attribution. Added `/commitments.md#3brain-coreplate-2026-conference-positioning-verify-current-coreplate-campaign-and-retrieve-application-material-on-next-3brain-check` for the required next-vendor-check verification.
 ### CelVivo ClinoStar / ClinoStar 2 campaign snippets — watchlist
 - **Instagram snippets:** [ClinoStar webinar copy](https://www.instagram.com/p/DbaUZjIjMgK) (score 0.335) describes clinostat-based simulated microgravity; [NexUs Locus live-demo copy](https://www.instagram.com/reel/DbKYC4NBtrN) (published 2026-07-24; score 0.291) promises on-site growth of larger, more physiologically relevant organoids; a separate [ClinoStar 2 post](https://www.instagram.com/p/DbSl7nkoFjK) (score 0.188) positions the system for NAMs and human-based drug-safety/efficacy evaluation.
 - Account provenance and dates are incomplete in the result set, and the query answer extrapolates an “installed base” that none of the URLs documents. One duplicate result carried a malformed/spam-like query string and was discarded.
 - The TheWell Bioscience xeno-free guide reappeared but adds nothing beyond the existing `celvivo-clinoreactor-thewell-bioscience-xeno-free` commitment.
 - **Robin relevance:** potentially useful current CelVivo messaging, but not proof of a launch, installation, or customer win. Added `/commitments.md#celvivo-clinostar-2-nams-demo-2026-verify-product-naming-and-campaign-provenance-on-next-celvivo-check` as a verification lead.
 ### Organ-on-chip, bioprinting, and regulatory context
 - **FDA, content current 2026-07-27:** [Accelerating and Modernizing Early and Late-Stage Clinical Development](https://www.fda.gov/industry/fda-actions-accelerate-and-modernize-early-and-late-stage-clinical-development) (score 0.566) explicitly includes human organ-on-chip systems among NAMs, alongside June 2026 cell/gene-therapy draft guidance and May 2026 streamlined nonclinical-safety guidance. This is authoritative US regulatory context, not a China-policy update.
 - **Molecular Cancer, published 2026-07-28:** [patient-derived 3D-bioprinted primary liver-cancer models](https://link.springer.com/article/10.1186/s12943-026-02751-1) (score 0.347), from Peking Union Medical College Hospital, adds China-based translational application evidence.
 - **npj Biomedical Innovations, published 2026-07-29:** [Challenges and opportunities in generating microvasculature using bioprinting techniques](https://www.nature.com/articles/s44385-026-00100-x) (score 0.177) adds application-domain context. The prior MDPI hepatic-organoid volumetric-bioprinting paper also reappeared.
 - China Order No. 818, CDE classification, CARsgen, CN Bio, NASA AVATAR, and Emulate results are re-mentions already captured in pull 5 or pull 6; no NMPA/CDE-direct corroboration appeared.
 ### Workflow tooling and agent memory — source-backed, low priority
 - **NousResearch Hermes Agent docs:** [api-server.md](https://github.com/NousResearch/hermes-agent/blob/main/website/docs/user-guide/features/api-server.md) (score 0.729) now exposes a July 2026 per-profile `API_SERVER_KEY` breaking-change warning and a runs API for long-form sessions, extending the stop/approval endpoint evidence captured in pull 6. A third-party Hermes Atlas report summarizes broader July changes; ReleaseBot's OpenClaw notes are not treated as Hermes release evidence.
 - **OpenWiki official repository:** [langchain-ai/openwiki](https://github.com/langchain-ai/openwiki) (score 0.416) is finally returned by the previously noisy OpenWiki/RAGFlow query and confirms the current connector set and user-authored instruction-brief behavior. It is a discovery/retrieval improvement, not evidence of a new OpenWiki release; no direct RAGFlow shift appeared.
 - **LLM-wiki pattern:** [arXiv 2607.24759v1](https://arxiv.org/html/2607.24759v1) (score 0.792) explicitly describes an LLM-maintained interlinked Markdown wiki between raw sources and agents; [LLM Wiki v2](https://gist.github.com/rohitg00/2067ab416f7bbe447c1977edaaa681e2) surfaced on 2026-07-30 (score 0.759) adds segmentation, librarian/retrieval, and schema-design discussion.
 - **Enterprise agent memory:** MinIO's [AIStor Memory announcement](https://www.hpcwire.com/bigdatawire/this-just-in/minio-launches-aistor-memory-the-enterprise-memory-foundation-for-agentic-ai) (2026-07-29; score 0.576) and [SiliconANGLE coverage](https://siliconangle.com/2026/07/29/miniio-debuts-aistor-memory-long-term-memory-ai-agents-need-scale-safely) (2026-07-30; score 0.524) corroborate the persistent, governed memory category already indexed as `agent-memory-architecture`.
 ### Exclusions and synthesis result
 - **Cellink:** Tavily's answer attributes the MDPI volumetric-bioprinting paper to BIO X, but the underlying result excerpt does not name CELLINK. Faryal Zahid's portfolio names Lumen X / BIO ONE / BIO X manuals but is documentation-history context, not a release or customer win. The existing Cellink commitment is unchanged.
 - **Femtobiomed:** the CellShot/CellPick query returned only a generic consumer 3D-printing article; its CellShot attribution is unsupported. No CellShot, CellPick, or TriArm evidence was promoted.
 - **Promoted:** two vendor-verification commitments (3Brain and CelVivo). **Not promoted:** no new theme row, open question, personal-logistics item, or China-regulatory commitment.
 - **Coverage:** fetched `2026-07-30T18:04:41.115Z`; 10 queries; raw `~/.openwiki/connectors/web-search/raw/2026-07-30T18-03-34-547Z/web-search-results.json`; instance `web-search-1`.
 ---
 ## 2026-07-31 18:04 pull
 Eighth Tavily pull, run as a stand-alone `openwiki personal --update` source ingest. **All 10 queries returned a structured `"error": "fetch failed"`** — no usable evidence this cycle. The same queries succeeded in pulls 1–7, so this looks like a Tavily-side / upstream network outage rather than a query-phrasing or scope problem. No theme refresh, no new commitments, no new open questions.
 ### Per-query result
 Every query in the 10-query lane returned the same structured error (no answer text, no result URLs):
 - `CelVivo ClinoReactor spheroid 2026` — error
 - `3Brain CorePlate MEA 2026` — error
 - `Cellink BIO X bioprinter 2026` — error
 - `organ-on-chip pharma collaboration 2026` — error
 - `CellShot CellPick bioprinter 2026` — error
 - `labs CelVivo ClinoStar installed base 2026` — error
 - `China cell therapy 3D bioprinting regulation 2026` — error
 - `Hermes Agent MiniMax M3 changelog 2026` — error
 - `OpenWiki connectors Tavily RAGFlow 2026` — error
 - `agent personal memory wiki 2026` — error
 ### Synthesis result
 - **No new vendor-anchored or application-domain evidence.** Tavily returned a structured `fetch failed` error on every query. All seven prior pulls remain the canonical evidence base; no wiki synthesis update is warranted this run.
 - **Operational note for the connector.** This is the first fully-failed pull since the Tavily lane was activated on 2026-07-26. If the next pull also fails, consider checking `TAVILY_API_KEY` validity, Tavily status page, or rate-limit posture before continuing to schedule the lane.
 - **Coverage:** fetched `2026-07-31T18:06:36.672Z`; 10 queries (all failed); raw `~/.openwiki/connectors/web-search/raw/2026-07-31T18-04-55-956Z/web-search-results.json`; instance `web-search-1`.
 ## 2026-08-01 18:09 pull
 **Gap-fill.** Pull 9 was ingested on 2026-08-01 between Tavily's last documented failed run (2026-07-31 pull 8) and this current run, but the prior `openwiki personal --update` cycle was git-repo-only and did not record a Tavily section. Pulling the raw data forward here so the connector's outage streak is auditable. **All 10 queries returned a structured `"error": "fetch failed"`** — same pattern as pull 8.
 ### Per-query result
 Every query in the 10-query lane returned the same structured error (no answer text, no result URLs):
 - `CelVivo ClinoReactor spheroid 2026` — error
 - `3Brain CorePlate MEA 2026` — error
 - `Cellink BIO X bioprinter 2026` — error
 - `organ-on-chip pharma collaboration 2026` — error
 - `CellShot CellPick bioprinter 2026` — error
 - `labs CelVivo ClinoStar installed base 2026` — error
 - `China cell therapy 3D bioprinting regulation 2026` — error
 - `Hermes Agent MiniMax M3 changelog 2026` — error
 - `OpenWiki connectors Tavily RAGFlow 2026` — error
 - `agent personal memory wiki 2026` — error
 ### Synthesis result
 - **No new vendor-anchored or application-domain evidence.** Backfills the gap between pull 8 and pull 10; pull 7 (2026-07-30) remains the canonical last successful Tavily pull.
 - **Coverage:** fetched `2026-08-01T18:09:15.810Z`; 10 queries (all failed); raw `~/.openwiki/connectors/web-search/raw/2026-08-01T18-07-35-101Z/web-search-results.json`; instance `web-search-1`.
 ---
 ## 2026-08-02 18:07 pull
 Tenth Tavily pull, run as a stand-alone `openwiki personal --update` source ingest on this connector. **All 10 queries returned a structured `"error": "fetch failed"`** — same pattern as pulls 8 (2026-07-31) and 9 (2026-08-01). This makes **three consecutive fully-failed Tavily pulls**, paralleling the HN connector's third-consecutive-empty-pull streak flagged in `/quickstart.md`'s Current status. No scope or query-phrasing change relative to pulls 1–7, which all produced usable evidence; the failure is Tavily-side / upstream.
 ### Per-query result
 Every query in the 10-query lane returned the same structured error (no answer text, no result URLs):
 - `CelVivo ClinoReactor spheroid 2026` — error
 - `3Brain CorePlate MEA 2026` — error
 - `Cellink BIO X bioprinter 2026` — error
 - `organ-on-chip pharma collaboration 2026` — error
 - `CellShot CellPick bioprinter 2026` — error
 - `labs CelVivo ClinoStar installed base 2026` — error
 - `China cell therapy 3D bioprinting regulation 2026` — error
 - `Hermes Agent MiniMax M3 changelog 2026` — error
 - `OpenWiki connectors Tavily RAGFlow 2026` — error
 - `agent personal memory wiki 2026` — error
 ### Synthesis result
 - **No new vendor-anchored or application-domain evidence.** Pull 7 (2026-07-30) remains the canonical last successful Tavily pull. All theme rows (`class-organoid-3d-bioprinting`, `china-cde-cell-gene-therapy-rules-2026`, `china-order-no-818-clinical-translation`, `MiniMax-m3`, `hermes-agent-v0-19-quicksilver`, `openwiki-brand`, `agent-memory-architecture`) keep their 2026-07-30 / 2026-07-29 / 2026-07-16 Last seen. No `commitments.md` and no `open-questions.md` change.
 - **Operational note for the connector.** Pull 10 is the third consecutive fully-failed pull (after pulls 8 and 9). The pull 8 note said: "If the next pull also fails, consider checking `TAVILY_API_KEY` validity, Tavily status page, or rate-limit posture before continuing to schedule the lane." That advice now applies; one fully-failed pull was a probable outage, two was a sustained outage, three is **a confirmed Tavily-side outage**. Recommend an unscheduled check of `TAVILY_API_KEY`, Tavily status, and rate-limit posture on disk before scheduling the next scheduled pull. Without that, the Tavily lane should be paused (per the same posture already recommended for the HN lane in `/quickstart.md`).
 - **Coverage:** fetched `2026-08-02T18:07:53.246Z`; 10 queries (all failed); raw `~/.openwiki/connectors/web-search/raw/2026-08-02T18-06-12-521Z/web-search-results.json`; instance `web-search-1`.
 ## Source coverage (cumulative)
 - Pull 1: fetched 2026-07-26T17:39:11Z — raw `~/.openwiki/connectors/web-search/raw/2026-07-26T17-38-33-286Z/web-search-results.json`
 - Pull 2: fetched 2026-07-26T18:07:27Z — raw `~/.openwiki/connectors/web-search/raw/2026-07-26T18-07-14-335Z/web-search-results.json`
 - Pull 3: fetched 2026-07-26T18:16:21Z — raw `~/.openwiki/connectors/web-search/raw/2026-07-26T18-16-06-804Z/web-search-results.json`
 - Pull 4: fetched 2026-07-27T18:04:46Z — raw `~/.openwiki/connectors/web-search/raw/2026-07-27T18-04-01-259Z/web-search-results.json`
 - Pull 5: fetched 2026-07-28T18:04:26Z — raw `~/.openwiki/connectors/web-search/raw/2026-07-28T18-03-43-560Z/web-search-results.json`
 - Pull 6: fetched 2026-07-29T18:03:26Z — raw `~/.openwiki/connectors/web-search/raw/2026-07-29T18-02-29-119Z/web-search-results.json`
 - Pull 7: fetched 2026-07-30T18:04:41Z — raw `~/.openwiki/connectors/web-search/raw/2026-07-30T18-03-34-547Z/web-search-results.json`
 - Pull 8: fetched 2026-07-31T18:06:36Z — raw `~/.openwiki/connectors/web-search/raw/2026-07-31T18-04-55-956Z/web-search-results.json` — **all 10 queries returned `"error": "fetch failed"`; no usable evidence**
 - Pull 9: fetched 2026-08-01T18:09:15Z — raw `~/.openwiki/connectors/web-search/raw/2026-08-01T18-07-35-101Z/web-search-results.json` — **all 10 queries returned `"error": "fetch failed"`; no usable evidence (gap-fill, not documented at the time)**
 - Pull 10: fetched 2026-08-02T18:07:53Z — raw `~/.openwiki/connectors/web-search/raw/2026-08-02T18-06-12-521Z/web-search-results.json` — **all 10 queries returned `"error": "fetch failed"`; no usable evidence**
 - Pull 11: fetched 2026-08-03T18:08:50Z — raw `~/.openwiki/connectors/web-search/raw/2026-08-03T18-07-31-803Z/web-search-results.json` — **first successful pull after the 3-day outage streak; Tavily back online; see section below**
 - Pull 12: attempted 2026-08-10T18:35Z — **skipped** (connector reported disabled; `TAVILY_API_KEY` not present; no raw files written; no synthesis update)
 - 2026-08-12 / 2026-08-15 / 2026-08-17 / 2026-08-18 / 2026-08-19 / 2026-08-20 / 2026-08-21 / 2026-08-22 update attempts: all **skipped** on the same code path (connector reported disabled; `TAVILY_API_KEY` not present; no raw files written; no synthesis update; tenth consecutive skip including 2026-08-22); see individual sections above for per-day operational notes
 - Queries: pulls 1, 2, 4, 5, 6, 7, 8, 9, 10, 11 = 10 queries each; pull 3 = 6 queries (vendor-anchored only)
 - Instance: `web-search-1`
 ---
 ## 2026-08-03 18:08 pull
 Eleventh Tavily pull, run as a stand-alone `openwiki personal --update` source ingest after the `web-search-1` connector's three-day outage streak (pulls 8/9/10 all returned `"error":"fetch failed"`). **Tavily is back online** — all 10 queries returned `answer` text + 2–8 results per query. The material findings are: the first credible **CELLINK × Volumetric "New Lumen X" release** signal on the Robin portfolio (Q3, score 0.819, 3DPrint.com 2026-07-28), a new **3Brain Utrecht Summer School "Human Brain Models" course** vendor-channel post (Q2, score 0.808, LinkedIn 2026-07-29), an independent **CelVivo ClinoStar 2 / Thailand Lab 2026** confirmation from an Indian distributor event page (Q6, score 0.696, labindia-analytical.com 2026-07-31), a **Hermes Agent 0.19.1** GitHub bug report (Q8, score 0.790, NousResearch issues/77000, 2026-08-02), and the first pull where Tavily's **answer text on 3Brain is correct** instead of mis-attributing an EEG-headset paper.
 ### CELLINK × Volumetric release new Lumen X for volumetric bioprinting — source-backed (vendor-anchored, high priority)
 - **3DPrint.com, 2026-07-28:** [CELLINK and Volumetric Release New Lumen X for Lumen X Bioprinting](https://3dprint.com/238627/cellink-volumetric-release-new-lumen-x-bioprinting-la) (score 0.819). Top hit on the Cellink BIO X bioprinter query. Tavily answer text corroborates: "The Cellink BIO X bioprinter is a digital light processing bioprinter set to be showcased at BioMET '26 in Vellore, India, from August 5–7, 2026. It operates with a wavelength of 405 nm and an intensi…" (truncated in the snippet). The Lumen X line is in Robin's portfolio table — this is the first vendor-anchored Lumen X release evidence in any Tavily pull.
 - **Cellink LinkedIn, 2026-07-29:** [Cellink exhibiting at BioMET '26 International Conference on Biomaterials](https://www.linkedin.com/posts/cellink_we-are-excited-to-be-exhibiting-at-biomet) (score 0.762). BioMET '26 Vellore India, 2026-08-05 → 2026-08-07. Cellink vendor channel confirms conference presence (India channel, not Robin's China channel — adjacent).
 - **CELLINK Facebook, 2026-07-28:** [CELLINK — Next stop second international conference](https://www.facebook.com/cellink3d/photos/next-stop-second-international-confere) (score 0.632). Companion post to the BioMET '26 LinkedIn announcement.
 - **CELLINK LinkedIn, 2026-07-28:** [From Star Trek to the Clinic: 3D Bioprinting Facility is Engineering Molecules for Patient](https://www.linkedin.com/posts/cellink_from-star-trek-to-the-clinic-3d-bioprinti) (score 0.560). U. Miami 3D Bioprinting Facility narrative — **re-mention** of the BIO X6 at U. Miami evidence already on `/commitments.md` `cellink-bio-x-gen3-customer-evidence`.
 **Robin relevance:** HIGH. Lumen X is in Robin's portfolio table; the CELLINK × Volumetric release is a credible direct product / partnership announcement on a product Robin actively sells. Per the brief's escalation rule ("CelVivo / 3Brain / Cellink / Femtobiomed news item with no prior row in wiki → write to `commitments.md` with a 1-line 'verify on next vendor check' status"), promoted to a NEW `/commitments.md` item `cellink-volumetric-lumen-x-release`. The BioMET '26 + U. Miami items are companion vendor-channel evidence folded into the existing `cellink-bio-x-gen3-customer-evidence` Notes (no new commitment). The `class-organoid-3d-bioprinting` theme row gets the Lumen X release added as a third vendor-anchored Cellink signal (alongside the BIO X Gen 3 / BIO X6 customer evidence already in the row).
 ### 3Brain Utrecht Summer School Human Brain Models course — source-backed (vendor channel)
 - **3Brain LinkedIn post, 2026-07-29:** [3Brain contributes to Utrecht Summer School course on Human Brain Models](https://www.linkedin.com/posts/3brain_3brain-neuroscience-hdmea-activity-7488166) (score 0.808). Tavily answer text: "The 3Brain CorePlate MEA 2026 is a high-density multi-well electrophysiology platform that supports both focused mechanistic studies and high-throughput screening workflows. It enables scalable, high-resolution electrophysiology for various biological models, including iPSC-derived neuronal or cardi…" — **first Tavily pull where the 3Brain answer is not mis-attribution**. 3Brain contributing an HD-MEA module to a Utrecht Summer School academic course positions CorePlate for the training / academic-channel segment, complementing the conference-booth evidence (ISSCR / ELRIG) already on the existing `3brain-coreplate-2026-conference-positioning` commitment.
 - **3Brain AG company page:** [3Brain AG - We empower researchers to explore intelligent biological networks](https://jp.linkedin.com/company/3brain) (score 0.839). Vendor corporate page anchoring the same HD-MEA messaging.
 - **AIP APL Bioengineering, 2026-07-29:** [Functional human-derived neurospheroids capture cortical-like network complexity](https://pubs.aip.org/aip/apb/article/10/3/036104/3399608/Functional-human-derive) (score 0.339). Application-domain paper on cortical-like networks in human neurospheroids — adjacent evidence for 3Brain-class HD-MEA readouts, not 3Brain-anchored.
 **Robin relevance:** Vendor-channel evidence on the existing `3brain-coreplate-2026-conference-positioning` commitment. The Utrecht Summer School post is the academic / training-channel counterpart to the ISSCR / ELRIG conference-booth evidence captured in pull 7. No new commitment; the existing commitment Notes are extended.
 ### CelVivo ClinoStar 2 + Thailand Lab 2026 (independent confirmation) — source-backed
 - **labindia-analytical.com News & Events, 2026-07-31:** [News & Events](https://stagging.labindia-analytical.com/News) (score 0.696). Top hit on the `labs CelVivo ClinoStar installed base 2026` query. Tavily answer text: "The CelVivo ClinoStar bioreactor is set to be showcased at Thailand Lab 2026, Bangkok, from September 2 to 4, 2026. The ClinoStar 2 model allows precise oxygen regulation and is used in various scient…" (truncated). **Independent confirmation** of two facts from an Indian distributor event page: (a) CelVivo is exhibiting at Thailand Lab 2026 in Bangkok 2026-09-02 → 2026-09-04, (b) `ClinoStar 2` is current product naming with oxygen regulation as a distinguishing feature.
 - The remaining 7 results on this query are Instagram snippets / rotational trophoblast organoids (ScienceDirect S2211124726007151) — same set already documented in pull 7's `celvivo-clinostar-2-nams-demo-2026` commitment; no new Instagram evidence to add.
 **Robin relevance:** Independent corroboration of the ClinoStar 2 product naming and the Thailand Lab 2026 booth — directly relevant to the existing `celvivo-clinostar-2-nams-demo-2026` verification commitment (the prior pull only had Instagram reels and a NexUs Locus demo snippet as evidence; this is the first non-Instagram, named-event confirmation). No new commitment; the existing commitment Notes are extended.
 ### Hermes Agent 0.19.1 GitHub bug report — source-backed (workflow tooling, low priority)
 - **GitHub NousResearch/hermes-agent issues/77000, 2026-08-02:** [[Bug]: Hermes Agent 0.19.1 gpt-5.6-luna + opencode-go](https://github.com/NousResearch/hermes-agent/issues/77000) (score 0.790). Confirms a Hermes Agent 0.19.1 patch release landed on the v0.19.x track — a same-week artifact on the Robin daily-driver stack (the prior HN pull on 2026-08-03 surfaced the v0.20.0 release at item `49159200`). Tavily answer text for the Hermes/M3 lane is **partially fabricated**: "release date of June 1, 2026" — Hermes v0.19 Quicksilver is dated 2026-07-25 (per pull 5 evidence), and there is no June 2026 Hermes release in the documented record. Treat the answer text as untrusted; the underlying GitHub issue URL is the credible signal.
 - **benchlm.ai, 2026-08-01:** [DeepSeek V4 Flash vs MiniMax M3: Benchmarks & Cost](https://benchlm.ai/compare/deepseek-v4-flash-vs-minimax-m3) (score 0.543). Third-party comparison reframing the M3 as "1M context window at $0.30…" — adjacent to `MiniMax-m3` theme row.
 - **unsloth/MiniMax-M3-GGUF, 2026-08-01:** [HuggingFace model card](https://huggingface.co/unsloth/MiniMax-M3-GGUF) (score 0.372). Quantized GGUF artifacts available from unsloth — confirms M3 is on the local-LLM run path. Adjacent to `MiniMax-m3` theme row.
 **Robin relevance:** WORKFLOW TOOLING (low priority). Refreshes `hermes-agent-v0-19-quicksilver` evidence column with the 0.19.1 GitHub bug report and `MiniMax-m3` with the benchlm + unsloth artifacts; does not change Last seen (already 2026-08-03 from the HN pull).
 ### Application-domain cross-anchor: 3D bioprinting + microfluidics convergence
 - **hbsn.amegroups.org, 2026-08-01:** [Spatial architecture and dynamic surveillance: 3D bioprinting and microfluidics converge](https://hbsn.amegroups.org/article/view/157425/html) (score 0.715 on `China cell therapy 3D bioprinting regulation 2026`; score 0.179 on `CellShot CellPick bioprinter 2026`). HepatoBiliary Surgery and Nutrition review covering bioprinted organoids + organ-on-chip intersection — same article surfaces on the China-regulation and the CellShot queries, indicating it is the most-cited adjacent peer-reviewed paper in this window. Cross-anchor between the organ-on-chip and 3D-bioprinting domains; folds into `class-organoid-3d-bioprinting` row evidence without spawning a new theme.
 - **Future Market Insights, 2026-07-29:** [AI-Accelerated Nonclinical Drug Testing Market](https://www.futuremarketinsights.com/reports/ai-accelerated-nonclinical-drug-tes) (score 0.536). Industry report — application-domain only.
 - **openpr.com, 2026-07-29:** [3D Bioprinting Market to Reach USD 6 Billion by 2035](https://www.openpr.com/news/4590634/3d-bioprinting-market-to-reach-usd-6-billion) (score 0.212). Market sizing — adjacent.
 - **FDA, 2026-07-28:** [New Approach Methodologies (NAMs)](https://www.fda.gov/science-research/science-and-research-special-topics/new-app) (score 0.124). **Re-mention** of the FDA NAMs framework first surfaced in pull 7; organ-on-chip included among New Approach Methodologies.
 - **Nature npj Biomedical Innovations, 2026-07-29:** [Challenges and opportunities in generating microvasculature using bioprinting techniques](https://www.nature.com/articles/s44385-026-00100-x) (score 0.180). **Re-mention** of the microvasculature review first surfaced in pull 7.
 ### Agent-memory-architecture cluster — new corroborating source
 - **akitaonrails/ai-memory, GitHub, 2026-07-28:** [docs/research-karpathy-llm-wiki.md](https://github.com/akitaonrails/ai-memory/blob/main/docs/research-karpathy-llm-w) (score 0.601). A third-party research write-up of the Karpathy LLM Wiki pattern — corroborates the `agent-memory-architecture` theme with another independent GitHub-side implementation / write-up. Combined with the prior 14+ distinct sources, the cluster is now 15+ and remains `source-backed`.
 - **Nvidia RTX Spark debut (tech-insider.org, 2026-07-28):** [128 GB Memory, 1 Petaflop AI PC](https://tech-insider.org/nvidia-rtx-spark-ai-pc-launch-2026) (score 0.558). Adjacent hardware — surfaces on the agent-memory query but is local-LLM inference hardware, not agent-memory architecture per se.
 **Robin relevance:** The akitaonrails write-up is a credible GitHub-side corroboration. Refreshes `agent-memory-architecture` Last seen → 2026-08-03 and adds to the evidence column.
 ### CellShot / Femtobiomed / OpenWiki-RAGFlow / Tavily answer-text quality
 - **CellShot / CellPick:** the GEN "Large Bioprinted Tissues Get a Precision Boost" article (already known from pull 6) reappears at 0.056; the **asiaresearchnews "Smart bioink shields delicate neural cells during precision bioprinting"** (2026-08-03, score 0.368) is a new adjacent application-domain article but has no Femtobiomed attribution; the **Pensées cultivated-meat platform at AFPRO** (2026-07-28, score 0.154), **Oxford Academic rbag142 "Three-dimensional bioprinted organoids: advances"** (2026-08-01, score 0.063) are application-domain / market context. **No Femtobiomed CellShot / CellPick / TriArm signal was promoted.**
 - **OpenWiki connectors Tavily RAGFlow 2026:** langchain-ai/openwiki GitHub (2026-08-01, score 0.511) reappears as the lone non-noise result; the lane still returns two Instagram reels. Confirms `openwiki-brand` cluster continuity but does not surface a new openwiki release or a RAGFlow ecosystem shift.
 - **Tavily answer-text quality improvement:** the 3Brain answer text on Q2 was correct for the first time in this 11-pull series — a positive connector-side signal worth flagging. The Cellink / Lumen X answer text on Q3 was vendor-anchored and substantive. The Hermes Agent / M3 answer text on Q8 was partially fabricated ("release date of June 1, 2026") — treat as untrusted. The CelVivo / ClinoStar installed-base Q6 answer text was correct and substantive (Thailand Lab 2026 + ClinoStar 2).
 ### Synthesis result
 - **Three new scope-aligned findings warranting commitment / theme updates:**
  1. **CELLINK × Volumetric release new Lumen X** — first direct Cellink product / partnership release evidence on the Robin portfolio. Promoted to a NEW `/commitments.md` item `cellink-volumetric-lumen-x-release` and to the evidence column of `class-organoid-3d-bioprinting` (third vendor-anchored Cellink signal alongside the existing BIO X Gen 3 / BIO X6 customer evidence).
  2. **3Brain Utrecht Summer School Human Brain Models course** — academic / training-channel evidence on the existing `3brain-coreplate-2026-conference-positioning` verification commitment. No new commitment; existing commitment Notes are extended.
  3. **CelVivo ClinoStar 2 / Thailand Lab 2026** — independent confirmation from an Indian distributor event page on the existing `celvivo-clinostar-2-nams-demo-2026` verification commitment. No new commitment; existing commitment Notes are extended.
 - **Workflow tooling refreshes:** `agent-memory-architecture` Last seen → 2026-08-03 (akitaonrails/ai-memory research doc added). `hermes-agent-v0-19-quicksilver` and `MiniMax-m3` evidence columns refreshed with same-week artifacts (Last seen unchanged at 2026-08-03 from the HN pull).
 - **Tavily answer-text quality:** the 3Brain answer is now correct (first time in 11 pulls); the Cellink Lumen X answer is substantive; the Hermes/M3 answer is partially fabricated ("release date of June 1, 2026") — treat as untrusted. Connector-side quality flag for future pulls: continue to treat Tavily answer text as untrusted; trust the underlying URL + score + published_date.
 - **Operational note for the connector:** Tavily is back online after a 3-day outage streak. The pull 8 / pull 9 / pull 10 advice to check `TAVILY_API_KEY`, Tavily status, and rate-limit posture no longer applies — the lane is functional again. No connector-side configuration change is required.
 - **Coverage:** fetched `2026-08-03T18:08:50.866Z`; 10 queries; raw `~/.openwiki/connectors/web-search/raw/2026-08-03T18-07-31-803Z/web-search-results.json`; instance `web-search-1`.
@@ -1,9 +1,15 @@
 ---
 type: "Reference"
 title: "Wiki.js 索引 — 跨 agent 文档发布层"
 openwiki_generated: true
 ---
 # Wiki.js 索引 — 跨 agent 文档发布层
 > 数据源: Wiki.js (http://10.10.10.254:3000/graphql) Biokingdom 实例
 > 用途: MiniMax code / Hermes 跨 agent 检索 "Robin 在 Wiki.js 发布了什么"
 > 更新: 自动同步计数 + 手动维护目录
-> 上次同步: **2026-07-27T18:30:03Z** · 当前 zh/literature 路径 (HTML probe): 0 页 · GraphQL sample (5 orderBy union): **82 unique pages** · ID range 22..1633 · 分布 en=5, zh=77
+> 上次同步: **2026-08-22T18:30:02Z** · GraphQL sample (5 orderBy union): **83 unique pages** · ID range 22..1704 · 分布 en=5, zh=78
 ## Wiki.js 概况
@@ -12,41 +18,17 @@
 | GraphQL API | `http://10.10.10.254:3000/graphql` |
 | Web UI (zh) | `http://10.10.10.254:3000/zh/home` |
 | Web UI (en) | `http://10.10.10.254:3000/en/home` |
-| **估计全页数** | **≥ 1633 (基于 max page id)** — server-side ID gap 显著,实际数大于 sample union |
+| **估计全页数** | **≥ 1704 (基于 max page id)** — server-side ID gap 显著,实际数大于 sample union |
-| Sample union (5 orderBy) | 82 unique pages (GraphQL 返 50 cap) |
+| Sample union (5 orderBy) | 83 unique pages (GraphQL 返 50 cap) |
-| Min / Max ID | 22 / 1633 |
+| Min / Max ID | 22 / 1704 |
-| Locale 分布 (sample) | en=5, zh=77 |
+| Locale 分布 (sample) | en=5, zh=78 |
-| Top-level 路径分布 (前 8, sample) | organoid=50, products=7, literature=6, articles=4, 3brain=2, 3brain-biocam-driver-api-v2-5=1, 3brain-hdmea-system=1, literature-deep-read=1 |
+| Top-level 路径分布 (前 8, sample) | organoid=50, products=7, literature=5, articles=4, 3brain=2, 3brain-biocam-driver-api-v2-5=1, 3brain-hdmea-system=1, instruments=1 |
 | 主题 | 类器官 / 3D 生物打印 / HD-MEA / CRISPR 类器官精准医疗 |
 | 维护者 | Robin + LDR (literature-reading-queue skill 自动发布) |
-> ⚠️ **GraphQL `pages.list(limit:N)` 实际 server-side cap 到 ~50**,无论 N 多大。**Robin 的真实 Wiki.js 库 ≥ 1000+ 页** (按 max page id 1633 推断),我 7/27 早的 "47" sample 是 server-side cap 的产物,**不是真实数**。多种 orderBy (TITLE / UPDATED / CREATED / ID / PATH) 5 个排序 union 才能看到 ID 1633,但仍未遍历完 1500+ 全部 page。完整全量只能通过爬 frontend / 直查 DB / 翻 Wiki.js 内部 API — 本 cron 不做。
+> ⚠️ **GraphQL `pages.list(limit:N)` 实际 server-side cap 到 ~50**,无论 N 多大。**Robin 的真实 Wiki.js 库 ≥ 1000+ 页** (按 max page id 推断),我 7/27 早的 "47" sample 是 server-side cap 的产物,**不是真实数**。多种 orderBy (TITLE / UPDATED / CREATED / ID / PATH) 5 个排序 union 才能看到 max_id,但仍未遍历完 1500+ 全部 page。完整全量只能通过爬 frontend / 直查 DB / 翻 Wiki.js 内部 API — 本 cron 不做。
 ## 主要页面分类 (按 URL path)
 ### 类器官 (organoid/list/*)
-
+...
 - 按器官系统分: nervoussystem / digestivesystem / breathsystem / urinarysystem / cardiovascular / reproductive / musculoskeletal / BloodImmune / tumor / others
 - 类器官综述: `organoid/review/organoid-review-2025` 🔥 类器官技术综述 3D 培养技术全解析
 ### 产品手册 (products/*)
 - 3Brain: BioCAM DupleX / HyperCAM Alpha / CorePlate / HD-MEA 等
 - CelVivo: ClinoStar 2 应用白皮书 v2.5 / ClinoStar 2 完整技术白皮书 V4.1
 - Cellink: BIO X 喷头校准操作指南 / CELLINK 生物墨水大全
 - Femtobiomed: CellShot 分区流式电转染系统
 ### … (其余分类保持稳定, 由 wikijs-obsidian-sync skill 同步时刷新)
 ## 跟 OpenWiki 同步策略
 - **新文章**: LDR 精读完后, 写 Obsidian + NocoDB + Wiki.js + **可选 OpenWiki sources/literature.md**
 - **OpenWiki 不直接 mirror Wiki.js**: Wiki.js 1300+ 页面太大, 只索引 + 触发查询
 - **跨 agent 触发**: 用户问 "Robin 有 X 主题资料吗" → 自动读本文件 → 找出对应 Wiki.js page id → 用 GraphQL single query 拿内容
 - **计数刷新**: `~/.local/bin/openwiki-update-sources.sh` 每天 02:30 跑一次
 ## 维护方式
 - 自动触发: `~/.local/bin/openwiki-update-sources.sh`
 - 手动触发: `bash ~/.local/bin/openwiki-update-sources.sh`
 - 数据格式: 跟 `productivity/wikijs-operations` skill 共用 (GraphQL token + 路径映射)
@@ -0,0 +1,124 @@
 ---
 type: "Reference"
 title: "Theme 1 · Organoid culture and equipment (CelVivo / 3Brain)"
 description: "Synthesis page for Robin's organoid culture and equipment theme — CelVivo ClinoStar/ClinoReactor for 3D suspension culture and 3Brain HD-MEA for neural/cardiac electrophysiology readout."
 tags: [theme, organoid, celvivo, 3brain, life-sciences]
 ---
 # Theme 1 · Organoid culture and equipment (CelVivo / 3Brain)
 This is the synthesis page for **类器官培养与设备** — Robin's core product line combining 3D suspension culture vessels (CelVivo ClinoStar / ClinoReactor) with HD-MEA electrophysiology readout (3Brain BioCAM DupleX / Accura-3D / CorePlate).
 ## What this theme covers
 - **Vendor portfolio:** CelVivo ApS (DK) and 3Brain AG (CH).
 - **Application domain:** MSC spheroids, patient-derived organoids (PDO), iPSC-derived brain / midbrain organoids (hMOs), assembloids, neural and cardiac electrophysiology.
 - **Workflow chain:** 3D culture (ClinoStar / ClinoReactor) → maturation (21–110 days) → functional readout (3Brain HD-MEA).
 - **Customer lane:** Chinese pharma R&D / CDMO / biotech + academic neuroscience (neural organoids).
 ## Vendor product mapping
 | Vendor | Hardware | Function | SKU / identifier |
 | --- | --- | --- | --- |
 | CelVivo | **ClinoStar** (30003) | Multi-well rotating-wall 3D culture | `30003` |
 | CelVivo | **ClinoReactor** (10004-12 / 10005-6 demo kit) | Single-use bioreactor, long-term 21–110 day culture | `10004-12`, `10005-6` |
 | CelVivo | **SP5D-24W** low-adherence plate | Anti-adhesion consumable for ClinoReactor | `SP5D-24W` |
 | 3Brain | **BioCAM DupleX** | HD-MEA acquisition system (hMOs / brain organoids) | `BioCAM DupleX` |
 | 3Brain | **Accura-3D** HD-MEA chip (4096 electrodes) | 3D / organoid-compatible chip | `Accura-3D` |
 | 3Brain | **CorePlate** (1W / 6W load) | High-resolution functional readout for iPSC neurons, cardiac models, brain organoids, assembloids, 3D spheroids | `CorePlate` |
 | 3Brain | **Sample Holder Set / PressNet** (UK GB2624872) | Mechanical net-press for CorePlate, 250–1250 µN load | `Sample Holder Set` |
 | 3Brain | **BrainWave 5/6** software | Unified acquisition + analysis | `BrainWave 5/6` |
 ## Workflow chain (CelVivo → 3Brain)
 ```mermaid
 stateDiagram-v2
    [*] --> Seeding: iPSC / MSC / biopsy
    Seeding --> EB_Formation: Day 0-7 (ClinoReactor)
    EB_Formation --> Maturation: Day 7-21 (ClinoStar 20 RPM)
    Maturation --> LongTermCulture: Day 21-110 (ClinoReactor / ClinoStar)
    LongTermCulture --> FunctionalReadout: transplant to 3Brain Accura-3D (4096 electrodes)
    FunctionalReadout --> DrugScreen: BrainWave 5 / spike-train analysis
    DrugScreen --> [*]
    note right of LongTermCulture
      Bosnjakovic 2025: Day 21 mature HepG2 3D spheroid + PAH exposure
      Raji 2026: Week 12 hMOs TH+ 58%
      Groningen: Day 110 / 8 mm brain organoid
    end note
    note right of FunctionalReadout
      3Brain HD-MEA is the gold-standard electrophysiology
      readout for organoids (Raji 2026 + 3Brain vendor docs)
    end note
 ```
 The state diagram shows the canonical CelVivo → 3Brain workflow: 3D suspension culture (ClinoReactor / ClinoStar) → maturation (21–110 days) → transplant to 3Brain HD-MEA → drug screening / disease modeling readout.
 ## Vendor evidence anchors
 ### CelVivo evidence
 - **Whitepaper: "Breaking the Bias" (2026, 16 pp)** — CelVivo's official vendor narrative on brain organoid long-term culture. Key data: ~110 day / 8 mm diameter brain organoid (Univ. Groningen, Trombetta-Lima); sc-RNA-seq 17,738 cells at Day 90 (Univ. Lausanne, Bagni); Day 30/45 dorsal forebrain comparison vs orbital shaker (Drexel, Qiang); hiPSC → cortical organoid + Omicron BA.5 (QIMR Berghofer, Stewart 2022). 4 patents: WO 2021/001472, WO 2021/245117, WO 2022/008292, WO 2022/144461. Full synthesis at [`/sources/literature-celvivo-brain-whitepaper-2026.md`](/sources/literature-celvivo-brain-whitepaper-2026.md).
 - **Bosnjakovic 2025 bioRxiv (PAH HepG2 3D spheroid, ClinoStar dynamic culture)** — 21-day maturation + 24h/96h BaP/BBF exposure; **4 metabolic markers (phenylalanine, TCA intermediates, GSH depletion, sphingolipid dysregulation) only appear in 3D, completely invisible in 2D**. Sales ammunition: "your 2D model is missing 100% of environmental toxicology early signals". Synthesis at [`/sources/literature-cel-bosnjakovic-2025-pah-deepread.md`](/sources/literature-cel-bosnjakovic-2025-pah-deepread.md).
 - **Miao 2025 Cell v2 (co-differentiation mesoderm + endoderm, vascularized lung/gut organoids, ClinoStar rotating culture)** — single 3D EB co-induction strategy yields **vHLPO with 7% ECs vs traditional HLPO 0%**, organ-specific endothelium + mesenchyme scRNA-seq validation, in-vivo functional integration with host circulation, FOXF1 mutation ACDMPV dual-pathology disease modeling. Product relevance: CelVivo ClinoStar rating 5 (co-differentiation depends on 3D EB self-organization in low-shear rotating culture — ClinoStar is the canonical hardware), HD-MEA rating 4, 3D bioprinting rating 3, patient-derived organoid drug screening rating 5. Synthesis at [`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`](/sources/literature-miao-2025-cell-vascularization-v2-deepread.md).
 - **Liu 2026 Nat Biomed Eng (shape-conformal porous framework for neural organoid e-phys, Rogers Lab)** — CelVivo ClinoStar rating 4 (organoid culture downstream of the shape-conformal framework; long-term maturation + functional readout is the canonical ClinoStar → HD-MEA workflow). Synthesis at [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md). See 3Brain evidence for the HD-MEA read side.
 - **Quintard 2024 Nat Commun (microfluidic platform integrating functional vascularized organoids-on-chip, 2026-08-16)** — CelVivo ClinoStar rating 3 (upstream workflow: BVO differentiation day 0-15 needs rotating-wall suspension culture; ClinoStar is the canonical hardware for this stage; the paper's day 15 → chip-on-board handoff is the canonical CelVivo → organ-on-chip workflow). Mimetas OrganoPlate rating 4 (direct Phaseguide-based vascularized / kidney / intestine organ-on-chip competitor — Robin's portfolio does not currently cover Mimetas but the platform represents a candidate cross-sell if Robin's customers ask "where do I run my CelVivo-matured organoids in a vascularized microenvironment?"). Emulate Organ-Chip rating 3 (Colon-Intestine-Liver platform companion). 10 通道并行微流控芯片 + hiPSC-BVO + 间充质球体 + 胰岛球体 + 肺类器官 跨类器官验证; 血管层级化 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管; 壁剪切 27-2000 s⁻¹ 完美匹配人体毛细血管生理范围 50-1900 s⁻¹. 4-commit LDR cycle 2026-08-16 (commits `0fc8db24` → `290e9635` → `24c713de` → `4073abf4` — last commit deleted the 3Brain reference per the SOP "硬门槛合规修正" cleanup rule because Quintard is organ-on-chip territory rather than 3Brain territory). Wiki IDs 1719/1720/1722, NocoDB Id 3297, DOI 10.1038/s41467-024-45710-4. Sales ammunition: "你的类器官前段培养到 day 15, 后段血管化怎么接? 我们的 CelVivo ClinoStar 提供 day 0-15 金标准旋转培养, 后接 Quintard 2024 微流控芯片做 30 天功能性血管化灌注". Customer entry: 药企临床前 (vascularized drug screening) + 微流控 organ-on-chip 平台集成商 (Mimetas / Emulate channel partners) + academic PI (vascular development / diabetes). Vault path: `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` (189 lines + 6 真图).
 - **Liang 2026 Sci Rep (mouse liver organoid 3-轨道 + fibrosis modeling, 2026-08-12)** — CelVivo ClinoStar rating 4 (P1-P10 长程扩增对应旋转培养 30+ 天无剪切; single DAPT only sustains P5, DAPT+Dex 协同才实现 P10 稳定成熟), CelVivo ClinoReactor rating 4 (单组织 3 轨道 [Hep/Cho/HSC] 分通道灌流; TGFβ 时间程序精确切换实现纤维化激活模型), CelVivo PhaseHolographic 成像 rating 3 (3D 球体直径/CV 实时 QC), 3Brain HD-MEA rating 3 (肝-神经互作延伸场景). 3 轨道 from 单份小鼠肝组织 (密度梯度离心 + 差速贴壁) → DAPT+Dex P1-P10 长程稳定成熟 (ALB / PAS / LDL / CYP 跨代保持) → TGFβ 5-7 天激活 qHSC → aHSC (Acta2/Col1a1 上调) → aHSC 共培养诱导 Hep-Orgs EMT (Snail/Twist/Vimentin ↑; ALB/CK8 ↓; Lgr5/EpCAM ↓; Ki67 ↓) = 体外肝纤维化模型. Wiki.js Id=1716, NocoDB Id=770, PMID 41857098. Page 946 9 项 SOP 重写版 + page 934 修齐 标杆 (4-commit LDR cycle 2026-08-12). **First deep-read whose `related:` field already names `[[MOC-类器官与3D培养]]`** on the day of publication — confirms MOC pattern in active use on real deep-reads. Vault path: `04-Literature/Deep-Reads/Liver/2026-08-12_Liang_2026_SciRep_liver_organoid_fibrosis_platform.md` (170 lines). Sales ammunition: "你的肝类器官只能短期培养? DAPT+Dex P1-P10 稳定成熟 + 单组织 3 轨道 + 14 天纤维化模型 — ClinoStar + ClinoReactor 一站搞定". Customer entry: 药企临床前 (抗纤维化药筛 14+ 天 3D 多细胞模型) + 临床肝活检中心 (1-2 mg 组织 → 3 周药敏 → ClinoReactor 6 通道一次测 6 药). Tracks in `/commitments.md` as `liang-2026-celvivo-clinostar-positioning`.
 - **Sales ammunition kit (CelVivo pricing + 8 Protocols + 5 app notes + 5 brand/whitepapers)** — Demo kit `10005-6` lists at €300 (Global Distributor Price, with special discount). 8 ClinoReactor Protocols cover prepare / media change / gardening / plate config / rotation-speed / alginate embed / VitroGel embed. 5 application notes cover HepG2/C3A liver, FTC-133 thyroid, NCI-H69V SCLC, TNBC, ClinoStar vs Orbital Shaker. Synthesis at [`/sources/sales-ammunition.md`](/sources/sales-ammunition.md).
 - **260528_CS vs OS app note (2026-07-17 deep read)** — ClinoStar vs Orbital Shaker shear-stress comparison for long-term 3D construct performance; ClinoStar has lower shear + long-term growth + better consistency. This is the **vs-competitor killer document** for "why not use an orbital shaker" customer questions.
 - **111_Planimetry app note (2026-07-17 deep read)** — Planimetry measurements of spheroids in ClinoReactor using FIJI (open-source). Standard answer for "how to quantify spheroids".
 ### 3Brain evidence
 - **Raji 2026 Mol Psychiatry (hMOs + 3Brain HD-MEA, 2026-07-27 deep read)** — WNT-modulated human midbrain organoids + 3Brain BioCAM DupleX + Accura-3D (4096 electrodes) + BrainWave 5. **TH+ 58% at 12 weeks** (vs 2D 18%, 3D static 32%). DA release 76 pg/mL (vs 2D 12, 3D static 28). α-synuclein PFF → DA neurons -35% / TH -40% / DA release -45% — establishes the **PD drug screening platform**. Shear-stress 15x lower than orbital shaking (0.13 dyn/cm² vs 2.03 dyn/cm²). Synthesis at [`/sources/literature-raji-2026-deepread.md`](/sources/literature-raji-2026-deepread.md).
 - **Liu 2026 Nat Biomed Eng (shape-conformal porous framework, full-coverage neural organoid e-phys, Rogers Lab)** — HD-MEA rating 5: **3000-8000 channels per organoid vs traditional MEA 200-1000 (10-50× improvement), >90% surface coverage vs 5-15%, weeks-long stable recording + bi-directional electrical + optogenetic stimulation, epilepsy + AD disease modeling**. The framework is the **direct next-generation design reference** for 3Brain's current 4096-electrode Accura-3D; Robin should sell Accura-3D as the existing best-in-class and Liu 2026 as the forward-looking 3D-coverage direction. Synthesis at [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md). Tracks as `liu-2026-hd-mea-roadmap-implication` commitment (verify with 3Brain whether flexible-electronics / shape-conformal framework is on their roadmap).
 - **Sharma 2026 Cell Stem Cell (vascularized retinal organoids, RGC survival)** — HD-MEA rating 4: paper uses 60-channel MCS MEA2100-Lite; 3Brain HD-MEA is same-generation HD technology, technical route is transferable. The W31 ON/OFF/ON-OFF light-response recording paradigm is the kind of long-duration, multi-class recording where HD spatial resolution matters most. CelVivo ClinoStar rating 3 (vascular network regresses in static culture → ClinoStar low-shear route candidate). W18 RGC yield **18.2% vs ctrl-RO 1.21% (15× improvement)** through C3 endothelial monolayer integration. Synthesis at [`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`](/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md).
 - **3Brain Sample Holder Set / PressNet (UK GB2624872)** — Mechanical net-press device for CorePlate 1W/6W; load force 250–1250 µN. Recorded 2026-07-07 (untracked in vault). Carryover evidence in [`/sources/git-repo.md`](/sources/git-repo.md) Notable entities.
 - **3Brain end-customer dossiers** — 11+ dossiers under `03-Resources/End-Customers/` covering 神经所 (上海), 北京大学, 北京天坛医院, 浙大一附院, 中科院昆明动物所, 西南医科大学, 贵州医科大学, plus TCM accounts at 云南中医药大学 and 天津创新中药. Listed in [`/sources/git-repo.md`](/sources/git-repo.md) Notable entities.
 - **Vendor-channel strand (Tavily 2026-07-30 → 2026-08-03)** — 3Brain's official website + LinkedIn (booth 412 at ISSCR 2026; booth 4 at ELRIG Drug Discovery; Utrecht Summer School "Human Brain Models" course 2026-07-29). Tracks in `/commitments.md` as `3brain-coreplate-2026-conference-positioning` (verify which conference posts are current and pull application notes).
 ## Cross-vendor workflow links
 - **CelVivo + 3Brain joint workflow** (from Raji 2026): hMOs are cultured in a **bioreactor** (CelVivo-class, low-shear rotating-wall) for 12 weeks; transplanted to **3Brain Accura-3D** (4096-electrode HD-MEA chip) for 24h spike-train recording via BrainWave 5. Two pieces of hardware from two vendors compose the **PD drug screening platform** Robin sells.
 - **CelVivo + 3Brain next-gen workflow** (from Liu 2026): the shape-conformal porous framework (Rogers Lab, next-gen HD-MEA design) records 3000-8000 channels per organoid vs current 4096 — **forward-looking direction** for the CelVivo → 3Brain pipeline. Track in `/commitments.md` as `liu-2026-hd-mea-roadmap-implication`.
 - **CelVivo + 3Brain vascularized organoid workflow** (from Miao 2025 v2 + Sharma 2026): vHLPO and vRO use single 3D EB co-induction (mesoderm+endoderm) or C3 endothelial monolayer integration. The vascular-like networks regress in static culture — **CelVivo ClinoStar low-shear rotating culture is the candidate route to extend maturation**. Functional readout remains 3Brain HD-MEA territory (60-channel MEA in Sharma; future HD-MEA for vascularized organoids).
 - **CelVivo + TheWell Bioscience xeno-free workflow** (Tavily 2026-07-21/23/25): TheWell's hydrogel-media workflow pages position **ClinoReactor as the scale-up vessel for apical-out organoids + hMSC expansion**. Tracks in `/commitments.md` as `celvivo-clinoreactor-thewell-bioscience-xeno-free` (verify whether sanctioned co-marketing).
 - **CelVivo + Femtobiomed** (small but complementary): Femtobiomed CellShot / CellPick / TriArm for hiPSC electroporation upstream of CelVivo 3D culture.
 ## Distribution and customer layer
 - **Agents (vendor-side technical contacts)** — [`/sources/agents.md`](/sources/agents.md) tracks Robin's actual distributor/agent network. Currently **1 active profile**: 董慧群 (CelVivo ClinoStar/ClinoReactor distributor technical contact; most fields 待补). Open question: see [`/open-questions.md`](/open-questions.md) `agent-dong-huiqun-celvivo` (agency company, region, contact info).
 - **Distributor map (261 dealers across 7 regions, 2026-07-24)** — [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md). Regional distribution: 华北 74 / 华东 68 / 华南 62 / 山东 25 / 湖北 19 / 西北 6 / 西南 7. Brand keyword map (top brands by region) is preserved. **Sensitive fields (phone/微信/邮箱/终端客户清单/商机金额) are not stored here** — they live in the private Obsidian vault.
 - **Active CelVivo commercial docs** — `05-Documents/Products/Celvivo/Industrial-Customers/` (惠百生物 demo discount agreement, 2026-06-21 PO盖章版, 2026 global distributor price book) — see [`/sources/git-repo.md`](/sources/git-repo.md) Notable entities.
 ## Regulatory and China-specific context
 - **China CDE cell & gene therapy classification rules (2026-07-24)** — affects CelVivo-class deals in the Chinese pharma R&D / CDMO customer base. Tracks in [`/commitments.md`](/commitments.md) `china-cde-cell-gene-therapy-rules-2026`.
 - **China Order No. 818 (effective 2026-05-01)** — accelerated clinical-translation pathway for cell therapy and 3D bioprinting at qualified hospitals. Tracks as `china-order-no-818-clinical-translation`.
 - **Guo 2026 Front Cell Dev Biol organoid IRB / ethics systematic review (2026-08-16)** — CelVivo ClinoStar ⭐⭐⭐⭐ clinical-translation IRB compliance; **Robin 推广 ClinoStar 给三甲医院时, 可附带 Guo 2026 框架作为增值**. The paper structures the IRB review framework as 7 mandatory points (sample provenance + donor informed consent + data privacy & de-identification + co-culture agency + animal welfare 3R + cross-border regulation + long-term storage & termination) + a 5-jurisdiction cross-border table (China《人类遗传资源管理条例》+《涉及人的生命科学和医学研究伦理审查办法》2023 vs US HIPAA + Common Rule + NIH GDS vs EU GDPR + Clinical Trials Regulation 536/2014 vs Japan / Korea). 3-commit LDR cycle 2026-08-16 (`2e6f5989` → `00f824f2` → `a4fa5a32`). Wiki.js ID 1724, NocoDB Id 3298, DOI 10.3389/fcell.2026.1721946. **Robin translated the paper into a customer-facing IRB application checklist template** at `templates/类器官IRB申请清单.md` v1.0 (180 lines; 7 mandatory points checklist + 5 customer Q&A + China vs International flow table + 10 attachments + 7 citations). Tracks in `/commitments.md` as `guo-2026-organoid-irb-checklist-rollout` (Owner: me; fold IRB application checklist into CelVivo industrial-customers program + Robin customer-training core material; commit the template and add a synthesis page at `/sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md`). Vault path: `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` (170 lines + 3 真图).
 - **China CGT 2026-07 developments** — Merck–Bio-Techne $11.3B acquisition, CARsgen satri-cel solid-tumor CAR-T approval (positive); gene-editing trial death + regulatory backlash (negative). Tracks as `china-cgt-2026-july-developments`.
 ## Cross-cutting relationship
 - **Vendor-channel evidence flows:** [`/sources/web-search.md`](/sources/web-search.md) is the primary vendor-news surface; Tavily answer text is **untrusted** (mis-attribution is common on this lane — see the consistent MO:BOT mis-attribution as ClinoReactor / 3Brain EEG-headset mis-attribution as CorePlate). Trust URLs + score + published date; treat answer text as low-confidence.
 - **Literature deep-read pipeline:** [`/sources/literature.md`](/sources/literature.md) tracks every paper Robin has read. Recent 30-day CelVivo count: 5; 3Brain: 1; adjacent vendors: 2. Most deep reads are routed into [`/themes/05-robin-research.md`](/themes/05-robin-research.md).
 - **Daily-driver AI tools touch this theme** through [`/themes/03-ai-agents.md`](/themes/03-ai-agents.md) (literature-deep-read SOP, RAGFlow KB cross-query). The MiniMax-M3 model is what reads CelVivo/3Brain PDFs during the LDR workflow.
 ## What to read next
 | Question | Go to |
 | --- | --- |
 | What is ClinoReactor's pricing? | [`/sources/sales-ammunition.md`](/sources/sales-ammunition.md) |
 | What does the CelVivo brain organoid whitepaper actually say? | [`/sources/literature-celvivo-brain-whitepaper-2026.md`](/sources/literature-celvivo-brain-whitepaper-2026.md) |
 | What is Raji 2026's PD drug screening story? | [`/sources/literature-raji-2026-deepread.md`](/sources/literature-raji-2026-deepread.md) |
 | What is Miao 2025's vascularized lung/gut organoid story? | [`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`](/sources/literature-miao-2025-cell-vascularization-v2-deepread.md) |
 | What is Liu 2026's shape-conformal neural organoid e-phys story? | [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md) |
 | What is Sharma 2026's vascularized retinal organoid RGC story? | [`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`](/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md) |
 | What is Liang 2026's liver organoid fibrosis platform story? | `04-Literature/Deep-Reads/Liver/2026-08-12_Liang_2026_SciRep_liver_organoid_fibrosis_platform.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
 | What is Quintard 2024's vascularized organoid chip story? | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
 | What is Guo 2026's organoid IRB / ethics story? | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
 | What is the IRB application checklist for organoid research? | `templates/类器官IRB申请清单.md` v1.0 (vault path; untracked) |
 | What distributors am I actually working with? | [`/sources/agents.md`](/sources/agents.md) |
 | Which Chinese dealers carry our brand? | [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) |
 | What regulatory shifts affect our Chinese pharma deals? | [`/commitments.md`](/commitments.md) China CDE / Order No. 818 / Guo 2026 IRB / China CGT items |
 | What conferences is 3Brain at this season? | [`/commitments.md`](/commitments.md) `3brain-coreplate-2026-conference-positioning` |
 | What's the CelVivo → 3Brain joint workflow? | [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) (this page) Workflow chain section |
@@ -0,0 +1,99 @@
 ---
 type: "Reference"
 title: "Theme 2 · 3D bioprinting (Cellink / BIONOVA)"
 description: "Synthesis page for Robin's 3D bioprinting theme — Cellink BIO X / BIONOVA X / Lumen X extrusion and DLP printing hardware for tissue engineering, drug tablets, and scaffold fabrication."
 tags: [theme, bioprinting, cellink, bionova, life-sciences]
 ---
 # Theme 2 · 3D bioprinting (Cellink / BIONOVA)
 This is the synthesis page for **3D 生物打印** — Robin's 3D bioprinting product line combining extrusion-based and DLP-based printers (Cellink BIO X / BIONOVA X / Lumen X) for tissue engineering scaffolds, personalized drug tablets, and 3D cell constructs.
 ## What this theme covers
 - **Vendor portfolio:** Cellink (BICO group) — BIO X, BIONOVA X, Lumen X, BIO X6.
 - **Application domains:** tissue engineering scaffolds, personalized-dose pharmaceutical tablets (SSE / DLP), 3D-printed organoid scaffolds, cell-laden hydrogel constructs, drug-delivery devices.
 - **Customer lane:** pharmaceutical R&D (personalized-dose oral solid dosage), tissue engineering labs, scaffold fabrication groups.
 - **Adjacent vendors:** Femtobiomed (electroporation upstream) — cross-references [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md).
 ## Vendor product mapping
 | Vendor | Hardware | Printing technology | Use case |
 | --- | --- | --- | --- |
 | Cellink | **BIO X** | Extrusion-based, modular printhead system (SSE / FDM / inkjet) | Tissue scaffolds, cell-laden hydrogels, tablets |
 | Cellink | **BIO X Gen 3** | Latest extrusion generation; observed in customer installs | Tissue engineering |
 | Cellink | **BIO X6** | Higher-throughput multi-printhead | Customer facility installs (e.g. U. Miami) |
 | Cellink | **BIONOVA X** | DLP / volumetric | High-resolution 3D structures |
 | Cellink | **Lumen X** | Volumetric DLP bioprinter | Fast volumetric bioprinting (seconds) |
 | Cellink | **New Lumen X** (2026-07-28 release, joint with Volumetric) | Next-gen volumetric | Watchlist — see below |
 ## Vendor evidence anchors
 ### Cellink BIO X — pharmaceutical printing
 - **Tasevska 2025 EJPS (HCTZ extended-release tablets, BIO X SSE)** — [`/sources/literature-tasevska-2025-deepread.md`](/sources/literature-tasevska-2025-deepread.md) is the canonical evidence. SSE half-solid extrusion vs DLP digital light processing comparison. **3D-SSE 12h release 85% (vs 58% pressed tablets)**, R²=0.94 (zero-order kinetics). 6-month accelerated stability ≥95% across 25/30/40°C (ICH Q1A compliant). 4x dose personalization (12.5/25/50 mg HCTZ) on the same BIO X system. Sales ammunition: "BIO X nozzle directly reproduces EJPS 2025 SSE process, 17-page appendix gives complete parameters, customer can replicate in 1 day, China HCTZ generic market >¥1B annual".
 - **BIO X customer installs (Tavily 2026-07)** — first vendor-anchored Cellink signal after 5 prior pulls of zero Cellink product mentions. Sources:
  - Nuclear Mechano-Oncology LinkedIn 2026-07 (BIO X Gen 3 installed, first hands-on training)
  - CELLINK official LinkedIn 2026-07-28 (BIO X6 at University of Miami 3D Bioprinting Facility)
  - Third-party market report LinkedIn 2026-07-28 (Cellink revenue uptick following strategic acquisitions)
  - appellaser.ro practical selection guide 2026-07-24 (BIO X Gen 3 general-purpose positioning)
 - Tracks in [`/commitments.md`](/commitments.md) as `cellink-bio-x-gen3-customer-evidence` — verify product-naming currency and whether named customer accounts map to active Chinese pharma R&D / CDMO opportunities.
 ### Cellink Lumen X — volumetric bioprinting
 - **CELLINK × Volumetric "New Lumen X" release (2026-07-28)** — 3DPrint.com top-hit (score 0.819). Tavily answer text corroborates with BioMET '26 Vellore India (2026-08-05 → 2026-08-07) showcase detail. Companion evidence: Cellink LinkedIn 2026-07-29 (BioMET '26 exhibiting post, score 0.762); CELLINK Facebook 2026-07-28 (second-conference post, score 0.632).
 - Tracks in [`/commitments.md`](/commitments.md) as `cellink-volumetric-lumen-x-release` — **first credible direct Cellink product / partnership release evidence on the Robin portfolio** after 10 prior Tavily pulls of mis-attribution or BIO X Gen 3 / BIO X6 customer evidence. Open verification questions: (a) CELLINK ↔ Volumetric relationship (co-marketing / OEM / distribution / acquisition); (b) "New Lumen X" SKU vs original Lumen X (volumetric DLP); (c) whether BioMET '26 Vellore maps to Chinese pharma R&D / CDMO / biotech opportunities (India channel rather than China channel — adjacent to Robin's region).
 ### Application-domain evidence (3D bioprinted organoids)
 The 3D bioprinting lane also captures application-domain papers that bioprint scaffolds for organoid culture — these are **vendor-adjacent** signals that fold into the [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) organoid culture theme rather than into Cellink hardware sales:
 - **Liu 2026 Nat Biomed Eng (shape-conformal porous framework, Rogers Lab, 2026-08-08 deep read)** — flexible-electronics microlattice fabrication as a 3D-bioprinting-adjacent technology for neural organoid scaffolds. **3D bioprinting rating 5** — the microlattice fabrication technique depends on 3D printing-class resolution (Cellink BIO X / BIONOVA X / Lumen X cannot directly print at this resolution today, but the field direction is clear: future bioprinters will integrate flexible-electronics fabrication). The framework records 3000-8000 channels per organoid (>90% surface coverage, weeks-long stable recording, epilepsy + AD disease modeling) — Robin should pitch Liu 2026 to Cellink to understand whether BIONOVA X or Lumen X can fabricate flexible-electronics-compatible microlattices. Synthesis at [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md). First entry in the new NocoDB table `Robin_Picked_Papers` (created 2026-08-08).
 - **MDPI Cells 2026-07-27** — "Rapid Volumetric Bioprinting Coupled with Dynamic Perfusion Enhances Human Hepatic Organoid Toxicity Testing"
 - **GEN 2026-07-29** — "Large Bioprinted Tissues Get a Precision Boost"
 - **HepatoBiliary Surgery and Nutrition 2026-08-01** — "Spatial architecture and dynamic surveillance: 3D bioprinting and microfluidics converge" (strongest same-week cross-anchor between organ-on-chip and 3D-bioprinting)
 - **npj Biomedical Innovations 2026-07-29** — microvasculature bioprinting review
 - **Molecular Cancer 2026-07-28** — patient-derived 3D-bioprinted primary liver cancer (Peking Union Medical College Hospital)
 These are vendor-adjacent signals in the `class-organoid-3d-bioprinting` theme row on [`/themes.md`](/themes.md), not vendor-anchored Cellink evidence.
 ## Cross-vendor workflow links
 - **Cellink BIO X ↔ CelVivo ClinoStar (scaffold + culture)** — bioprinted scaffold (BIO X) is seeded with cells and matured in ClinoStar/ClinoReactor. Joint workflow opportunity: pharmaceutical-grade 3D-printed scaffolds for organoid maturation (cross-references [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) Workflow chain section).
 - **Cellink ↔ Femtobiomed CellShot** — CellShot (continuous-flow electroporation) prepares hiPSC cells that are then bioprinted into scaffolds via BIO X. Adjacent cross-sell for both vendors.
 ## Distribution and customer layer
 - **Distributor map (261 dealers across 7 regions)** — [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) — same regional breakdown as CelVivo/3Brain. Brand keyword map: Thermo 19 / Bio-Rad 11 / 蔡司 6 / Cytiva 6 / 伯乐 6 / 徕卡 6 / 赛多利斯 5 / Eppendorf 5 / Leica 5 / Beckman 4 / Merck 4 / Waters 4 / Azure 3 / Bruker 3 / Oxford Nanopore 3 / Agilent 3 / Sartorius 3. **Cellink-specific regional distribution is not yet broken out** (deferred to next update).
 - **Agents currently in the network** — [`/sources/agents.md`](/sources/agents.md) — currently focused on CelVivo (董慧群); **no Cellink-specific distributor technical contact** is recorded. Open question: do existing CelVivo contacts also push Cellink, or is there a separate Cellink distributor?
 ## Regulatory and standards context
 - **FDA NAMs framework (2026-07-27)** — organ-on-chip included among New Approach Methodologies alongside June 2026 cell/gene-therapy draft guidance. Bioprinted tissue constructs fit into the NAMs framing. Folds into the existing `class-organoid-3d-bioprinting` theme row evidence on [`/themes.md`](/themes.md).
 - **China Order No. 818 (effective 2026-05-01)** — accelerated clinical-translation pathway covers **3D bioprinting** alongside cell therapy. Tracks as `china-order-no-818-clinical-translation` on [`/commitments.md`](/commitments.md).
 ## Cross-cutting relationship
 - **Vendor-channel evidence flows:** [`/sources/web-search.md`](/sources/web-search.md) is the primary surface; the Tavily query lane that surfaces Cellink evidence uses the vendor-anchored query `Cellink BIO X bioprinter 2026`. Tavily answer text mis-attribution is **common** on this lane — the consistent `MO:BOT` mis-attribution as BIO X / ClinoReactor / BIO X Gen 3 means the underlying URL is the only trustworthy signal.
 - **Hacker News footprint:** zero. [`/sources/hackernews.md`](/sources/hackernews.md) confirms that `Cellink` returns only string-collision hits (Popkorn CSS, Reflect Orbital, Draco scraper). Tavily remains the only signal lane.
 - **Literature deep-read pipeline:** [`/sources/literature.md`](/sources/literature.md) — Cellink_literature NocoDB table has 2,499 entries (largest single-vendor corpus); Cellink vault `04-Literature/Deep-Reads/Cellink/` has 129 deep-read notes. Only 1 recent deep read (Tasevska 2025, 2026-07-27); the pipeline is under-loaded relative to corpus size.
 ## Backlog for this theme
 The bioprinting theme is **evidence-light compared to theme 1 (organoid-equipment)** — only 1 recent vendor deep read (Tasevska) and 1 vendor-channel release (CELLINK × Volumetric new Lumen X). To deepen:
 - **Cellink BIONOVA X evidence** — no deep-read or vendor-channel evidence yet; surface on next Tavily pull.
 - **Cellink-specific distributor coverage in China** — extend [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) to break out Cellink-bearing dealers by region.
 - **Scaffold + organoid joint workflow case studies** — the cross-vendor CelVivo+Cellink workflow is the most differentiated sales story; document at least one end-to-end example.
 - **3D-printed scaffold for neural/cardiac organoids** — overlaps with theme 1 (3Brain readout). Add case study after next literature pass.
 ## What to read next
 | Question | Go to |
 | --- | --- |
 | What is the BIO X SSE process for HCTZ tablets? | [`/sources/literature-tasevska-2025-deepread.md`](/sources/literature-tasevska-2025-deepread.md) |
 | Is the New Lumen X product release verified? | [`/commitments.md`](/commitments.md) `cellink-volumetric-lumen-x-release` |
 | Are there BIO X Gen 3 / BIO X6 customer installs in China? | [`/commitments.md`](/commitments.md) `cellink-bio-x-gen3-customer-evidence` |
 | What distributors carry Cellink in China? | [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) |
 | What 3D bioprinted-organoid reviews have come out this month? | [`/sources/web-search.md`](/sources/web-search.md) 2026-07-29 / 2026-07-30 / 2026-08-03 pulls |
 | What is Liu 2026's shape-conformal neural organoid framework story (microlattice + flexible electronics)? | [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md) |
@@ -0,0 +1,146 @@
 ---
 type: "Reference"
 title: "Theme 3 · AI Agent tools (Hermes / Codex / MiniMax code)"
 description: "Synthesis page for Robin's daily-driver AI agent stack — Hermes Agent on WSL, MiniMax code on the desktop, Codex CLI fallback, OpenWiki as cross-agent memory substrate, and supporting toolchain (RustDesk, Gitea, Wiki.js, RAGFlow)."
 tags: [theme, ai-agent, hermes, codex, openwiki, workflow-tooling]
 ---
 # Theme 3 · AI Agent tools (Hermes / Codex / MiniMax code)
 This is the synthesis page for **AI Agent 工具** — Robin's daily-driver stack for autonomous work. The stack has three primary agent surfaces (Hermes Agent on WSL, MiniMax code on the desktop, Codex CLI), with OpenWiki as the cross-agent memory substrate and a local-fleet support layer (RustDesk remote, Gitea wiki, RAGFlow KB cross-query).
 ## What this theme covers
 - **Primary agent surfaces:** Hermes Agent v0.19 "Quicksilver" (→ v0.20.0 in 2026-08-03), MiniMax code (desktop), Codex CLI (fallback).
 - **Inference provider:** MiniMax-M3 (1M context multimodal) → MiniMax-H3 frontier model (2026-08-03 launch cluster).
 - **Memory substrate:** OpenWiki (LangChain open-source, local markdown wiki) + Gitea (public read-only mirror).
 - **Cross-agent tooling:** 4 OpenWiki bridge skills (MiniMax code reads OpenWiki); literature-deep-read SOP; sales-ammunition query skill; 4-connector cron pipeline.
 - **Remote / access:** RustDesk self-hosted hbbs + hbbr for ITX host remote control (2026-08-05).
 ## Agent stack architecture
 ```mermaid
 flowchart TD
    User[Robin · desktop / mobile]
    subgraph DesktopWSL[WSL · primary host]
        Hermes[Hermes Agent v0.19 Quicksilver]
        Cron1["cron 02:00 (openwiki-update.sh)"]
    end
    subgraph DesktopPC[Windows desktop · secondary]
        MiniMaxCode["MiniMax code (+ 4 bridge skills)"]
        CodexCLI[Codex CLI fallback]
    end
    subgraph Remote[ITX 24h host · future]
        ITXHermes["Hermes Agent (on Ubuntu 22.04)"]
    end
    subgraph Memory[Memory substrate]
        OpenWiki[("OpenWiki (local markdown wiki)")]
        Gitea["Gitea public mirror (10.10.10.254:3080)"]
    end
    subgraph KB[Knowledge backends · NAS]
        RAGFlowKB["RAGFlow (18 KB · 32709 docs)"]
        NocoDBDB["NocoDB (13 lit tables)"]
        SeaFileStore["SeaFile (4 repos · 77 GB)"]
        WikiJS["Wiki.js (1500+ pages)"]
    end
    subgraph LLM[Local inference · see theme 04]
        MiniMaxM3[MiniMax-M3 1M context]
        Ollama[Ollama · qwen2.5vl:7b]
        Reranker[bge-reranker]
    end
    User -->|primary chat| Hermes
    User -->|desktop tasks| MiniMaxCode
    User -->|fallback| CodexCLI
    Hermes -->|reads / writes| OpenWiki
    MiniMaxCode -->|bridge skills read| OpenWiki
    Cron1 -->|HN + Tavily + git-repo ingest| OpenWiki
    Cron1 -->|M3 agent synthesis| OpenWiki
    OpenWiki -->|commit + push| Gitea
    Hermes -->|cross-query| RAGFlowKB
    Hermes -->|metadata| NocoDBDB
    Hermes -->|PDF retrieval| SeaFileStore
    Hermes -->|published deep reads| WikiJS
    ITXHermes -.future.-> OpenWiki
    Hermes -.inference.-> MiniMaxM3
    RAGFlowKB -.embedding.-> Ollama
    RAGFlowKB -.rerank.-> Reranker
 ```
 The architecture shows three agent surfaces sharing the OpenWiki memory substrate, which mirrors to a public Gitea repo for cross-device reading. The four NAS-backed knowledge systems (RAGFlow / NocoDB / SeaFile / Wiki.js) are queried by Hermes on demand and route evidence into the wiki synthesis layer.
 ## Primary agent surfaces
 ### Hermes Agent (WSL primary)
 - **v0.19 "Quicksilver" release (2026-07-25)** — first-token delay 4.3s → 0.9s, profile routing, live subagent, delivery ledger, 1Password/Bitwarden integration. Tracks on [`/themes.md`](/themes.md) `hermes-agent-v0-19-quicksilver` row.
 - **v0.19.1 patch (2026-08-02)** — NousResearch issues/77000 GitHub bug report ("gpt-5.6-luna + opencode-go"). Confirms patch-version activity on the v0.19.x track between v0.19 and v0.20.0.
 - **v0.20.0 release (2026-08-03, tag `v2026.8.3`)** — next major version after v0.19 Quicksilver. HN item `49159200` (1pt day-of, but the GitHub release is the authoritative primary source). Last-seen refresh applied to `hermes-agent-v0-19-quicksilver` row description; v0.20.0 features not yet documented in source-page synthesis.
 - **`configuration.md` (2026-07-26)** — documents iteration-budget behavior change (April 2026: removed premature 70%/90% warnings; now single wrap-up at 500/500 with grace call).
 - **`features/api-server.md` (2026-07-27)** — documents new `/v1/runs/{run_id}/stop` + `/approval` endpoints with MiniMax-M3 as the documented default model. Updated 2026-07-30 with a per-profile `API_SERVER_KEY` breaking-change warning and a runs API for long-form sessions.
 - **MCP 2026-07-28 protocol revision (adjacent watchlist)** — finalized not-backward-compatible revision. Relevant to OpenWiki's MCP server architecture. Folded into `hermes-agent-v0-19-quicksilver` evidence column.
 ### MiniMax code (Windows desktop)
 - **4 OpenWiki bridge skills** — allow MiniMax code to cross-agent query the OpenWiki memory substrate (reads [`/sources/literature.md`](/sources/literature.md) on "what did Robin recently read", reads [`/sources/agents.md`](/sources/agents.md) on "who are the distributors", reads [`/sources/wikijs.md`](/sources/wikijs.md) on "is there an X topic in Wiki.js", reads [`/sources/sales-ammunition.md`](/sources/sales-ammunition.md) on "ClinoReactor sales ammunition"). See [`/sources/OpenWiki速查手册.md`](/sources/OpenWiki速查手册.md) §5.
 - **Inference provider:** MiniMax-M3 (1M context multimodal) — daily-driver model for cross-agent tasks. See [`/themes/04-local-llm.md`](/themes/04-local-llm.md) for the broader local-LLM fleet.
 - **Adjacent: openclaw-bridge v1.5** — MiniMax code cross-agent index, sits on top of the 4 OpenWiki bridge skills.
 ### Codex CLI (fallback)
 - **Used only when Hermes or MiniMax code is unavailable** — not the primary surface. Codex CLI itself has 42 HN hits in the 2026-08-03 pull (`49159200` Hermes + MiniMax-H3 cluster is the only workflow-relevant signal), all of which are surface-level generic agent wrappers/TUIs/skills products (e.g. `49107749` Agent-Manager Tmux TUI 80 pts; `49110007` Aggregated Claude Code sessions 1 pt). Codex CLI itself is **not** the canonical Robin agent — it is the fallback.
 ## Cross-agent memory substrate: OpenWiki
 - **OpenWiki = LangChain 7/10 open-source "personal brain" framework.** Local markdown wiki rooted at `~/.openwiki/wiki`, mirrored to Gitea public `http://10.10.10.254:3080/Robin/openwiki-wiki`. Cron pipeline: every night 02:00 `openwiki-update.sh` (HN + Tavily + git-repo + M3 agent synthesis) → commit → push to Gitea. Every 02:30 `openwiki-update-sources.sh` (NocoDB + SeaFile + Wiki.js + RAGFlow health checks) → commit → push.
 - **Five canonical synthesis pages** — [`/quickstart.md`](/quickstart.md), [`/themes.md`](/themes.md), [`/commitments.md`](/commitments.md), [`/open-questions.md`](/open-questions.md), [`/personal-logistics.md`](/personal-logistics.md). Five detailed theme pages under [`/themes/`](/themes/).
 - **Evidence layer** — 21 source pages under [`/sources/`](/sources/), one per active connector or subsystem.
 - **Activation manual:** [`/README-ACTIVATION.md`](/README-ACTIVATION.md) (2026-07-27 update). 8 sections covering TL;DR / connectors not yet on / daily operations / what Robin manually does / what Robin never touches / cross-tool cheat sheet / today's real system status / changes from 7-26 / next steps.
 - **Cheat sheet:** [`/sources/OpenWiki速查手册.md`](/sources/OpenWiki速查手册.md) (2026-07-27 one-shot reference for talking to colleagues / boss / agents about what OpenWiki is).
 ## Supporting toolchain (AI-side)
 ### Literature-deep-read (LDR) skill
 - **Master template:** [`/sources/ldr-report-template.md`](/sources/ldr-report-template.md) — 8 铁律 + 3 trigger modes (精简 4 步 vs 完整 8 步 vs 自动) + 5-section report template (做什么 / 3 发现 / 4 维产品对接 / 局限 / 转发语+落款+PDF). Total report length 800–1500 characters.
 - **SOP lessons:** [`/sources/2026-07-27-4-27-sop-vs-implementation.md`](/sources/2026-07-27-4-27-sop-vs-implementation.md) — 9-step SOP vs 7-27 凭印象实操 comparison. PyMuPDF xref dedup + 30KB filter + p1 logo 剔除. NocoDB v1 + JSON body (范本 v2 fails 3x). SeaFile `?dl=1` suffix required. 3-frame SeaFile image 嵌入 markdown.
 - **Toolchain打通战报:** [`/memory-2026-07-16-tools-final.md`](/memory-2026-07-16-tools-final.md) — 2026-07-16 OpenWiki + Gitea + NocoDB + RAGFlow + Wiki.js + MiniMax code 端到端打通. 9 链路.
 ### Remote access (RustDesk)
 - **Self-hosted hbbs + hbbr:** [`/sources/rustdesk-sop.md`](/sources/rustdesk-sop.md) — NAS Unraid container, OpenWrt frpc → Tencent 轻量云 frps, ITX rustdesk 1.4.9 client. Permanent password `Ldw811223!`, ITX ID `263 739 134`. Supports Robin's planned 24h ITX host build ([`/commitments.md`](/commitments.md) `itx-24h-host-build-2026-q3`).
 - **ITX 24h host build plan** — mATX + i5-12400 + DDR4-2666 32G + dual-NIC (板载 Realtek 1Gb + Intel PRO/1000 GT) NAS isolation. Budget ¥2,985.82, 10/11 parts arrived. Plan: Ubuntu Server 22.04 LTS install + 双网卡静态 IP + Hermes Agent install + 24h soak test.
 ### Public mirror (Gitea)
 - **Gitea repo:** `Robin/openwiki-wiki` public, `http://10.10.10.254:3080`. Robin can read on phone / desktop browser without auth. Commit + push happens automatically after each OpenWiki cron run.
 ## Adjacent workflow signals (HN / Tavily)
 - **`agent-memory-architecture` theme row** on [`/themes.md`](/themes.md) — clusters Karpathy LLM Wiki + Google OKF + MCP + verginglabs.com "A Markdown wiki outscored every AI agent memory product we benchmarked" (HN `49156055`, 2 pts, watchlist). 15+ distinct sources on the shared-agent-memory pattern. OpenWiki aligns with this lane (Open Knowledge Format front-matter is the structural backbone).
 - **Tavily / Hermes / MiniMax-M3 lane** — Tavily answer text on this lane is **partially fabricated** (e.g. Tavily claimed a "release date of June 1, 2026" for Hermes v0.19 Quicksilver; the actual release is 2026-07-25 per Nous Research). Trust underlying URLs + GitHub release tags; ignore Tavily answer text.
 ## Cross-cutting relationships
 - **Depends on [`/themes/04-local-llm.md`](/themes/04-local-llm.md)** — every Hermes / MiniMax code call is served by local-LLM inference (Ollama / bge-reranker / RAGFlow retrieval). When the desktop AI service is down (7997 / 8090 / 11434), cross-agent RAGFlow queries fall back to metadata-only.
 - **Writes to [`/themes/05-robin-research.md`](/themes/05-robin-research.md)** — the M3 agent synthesis step is what routes evidence into the personal-research theme (deep reads, vendor product signals, demo plans).
 - **Touches [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md)** and [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md)** through the LDR pipeline — every deep read on CelVivo / 3Brain / Cellink / Femtobiomed goes through the LDR master template + SOP.
 ## Backlog for this theme
 - **Codex CLI adoption question** — currently the fallback agent; no active usage notes. Decide whether to expand Codex into a second-primary surface or keep as fallback-only.
 - **Hermes v0.20.0 feature documentation** — only the GitHub release tag is in evidence; the changelog has not been deep-read. Add to next Tavily pull's `Hermes Agent MiniMax M3 changelog 2026` query.
 - **OpenWiki bridge skill expansion** — currently 4 skills. Decide whether to add cross-KB retrieval skills (RAGFlow live query) now that embedding service is intermittent.
 - **MiniMax-H3 adoption** — HN launch cluster 2026-08-03 (ComfyUI 167pts + HuggingFace 8pts + LMSYS Twitter 2pts); decide whether H3 replaces M3 as the daily-driver inference.
 ## What to read next
 | Question | Go to |
 | --- | --- |
 | What is OpenWiki and how do I use it? | [`/sources/OpenWiki速查手册.md`](/sources/OpenWiki速查手册.md) |
 | What connectors does OpenWiki have? | [`/README-ACTIVATION.md`](/README-ACTIVATION.md) |
 | What is the LDR report format? | [`/sources/ldr-report-template.md`](/sources/ldr-report-template.md) |
 | What are the LDR SOP lessons? | [`/sources/2026-07-27-4-27-sop-vs-implementation.md`](/sources/2026-07-27-4-27-sop-vs-implementation.md) |
 | How is RustDesk configured? | [`/sources/rustdesk-sop.md`](/sources/rustdesk-sop.md) |
 | What did Robin do on 2026-07-16 (toolchain通)? | [`/memory-2026-07-16-tools-final.md`](/memory-2026-07-16-tools-final.md) |
 | What is the ITX 24h host build? | [`/commitments.md`](/commitments.md) `itx-24h-host-build-2026-q3` |
@@ -0,0 +1,217 @@
 ---
 type: "Reference"
 title: "Theme 4 · Local LLM deployment (Ollama / bge-reranker / RAGFlow)"
 description: "Synthesis page for Robin's local-LLM fleet — Ollama serve + qwen2.5vl:7b vision model + BAAI/bge-m3 embeddings (Ollama + LM Studio) + bge-reranker rerank + RAGFlow KB retrieval + adjacent NAS subsystems (NocoDB / SeaFile / Wiki.js / Feishu mail)."
 tags: [theme, local-llm, ollama, bge-reranker, ragflow, workflow-tooling]
 ---
 # Theme 4 · Local LLM deployment (Ollama / bge-reranker / RAGFlow)
 This is the synthesis page for **本地大模型部署** — Robin's local inference and retrieval layer that serves the entire agent stack documented in [`/themes/03-ai-agents.md`](/themes/03-ai-agents.md). The fleet combines an Ollama serve with multimodal + embedding models, an LM Studio instance running `BAAI/bge-m3`, a bge-reranker rerank service, and a RAGFlow KB layer; four adjacent NAS subsystems (NocoDB / SeaFile / Wiki.js / Feishu mail) sit alongside RAGFlow and share the same daily cron health-check pipeline.
 ## What this theme covers
 - **Local inference runtime:** Ollama serve on the desktop (host `192.168.192.67`, port `11434`) running `qwen2.5vl:7b` for vision and `nomic-embed-text` / `BAAI/bge-m3` for embeddings.
 - **Local reranker:** bge-reranker served on desktop port `8090`.
 - **Local embedder (LM Studio):** `BAAI/bge-m3` on port `7997` (LM Studio OpenAI-compatible API).
 - **KB retrieval layer:** RAGFlow (`http://10.10.10.254:9980`) — 18 KB / 32,709 docs / 116,254 chunks as of last sync 2026-08-03.
 - **Adjacent NAS subsystems:** NocoDB (`http://10.10.10.254:8081`), SeaFile (`http://10.10.10.254:9898`), Wiki.js (`http://10.10.10.254:3000`), Feishu mail (IMAP polling, awaiting Robin's IT password).
 ## Local-LLM fleet architecture
 ```mermaid
 flowchart TD
    subgraph Desktop["Desktop · 192.168.192.67"]
        OllamaServe["Ollama serve :11434"]
        QwenV["qwen2.5vl:7b (vision)"]
        NomicE["nomic-embed-text (embed)"]
        LMStudio["LM Studio :7997"]
        BgeM3LM["BAAI/bge-m3 (embed via LM Studio)"]
        Reranker["bge-reranker :8090"]
        OllamaServe --> QwenV
        OllamaServe --> NomicE
        LMStudio --> BgeM3LM
    end
    subgraph NAS["NAS · 10.10.10.254"]
        RAGFlow["RAGFlow KB :9980 (18 KB / 32,709 docs)"]
        NocoDB["NocoDB :8081 (13 lit tables)"]
        SeaFile["SeaFile :9898 (4 repos / 77 GB)"]
        WikiJS["Wiki.js :3000 (~1500 pages)"]
        Feishu["Feishu mail IMAP poll (awaiting creds)"]
    end
    subgraph Agents["Agents (see theme 03)"]
        Hermes[Hermes Agent]
        MiniMaxCode[MiniMax code]
        CronDaily["cron 02:30 update-sources.sh"]
    end
    RAGFlow -.embedding.-> OllamaServe
    RAGFlow -.embedding.-> LMStudio
    RAGFlow -.rerank.-> Reranker
    Hermes -->|query| RAGFlow
    MiniMaxCode -->|cross-query| RAGFlow
    Hermes -->|metadata| NocoDB
    Hermes -->|PDF retrieval| SeaFile
    Hermes -->|published deep reads| WikiJS
    MiniMaxCode -.future.-> Feishu
    CronDaily -->|health probe| RAGFlow
    CronDaily -->|count refresh| NocoDB
    CronDaily -->|count refresh| SeaFile
    CronDaily -->|count refresh| WikiJS
    QwenV -.vision OCR.-> LDR["LDR SOP (theme 05)"]
 ```
 The diagram shows the three local inference services (Ollama serve, LM Studio, bge-reranker) feeding the RAGFlow KB layer, with the four NAS subsystems (NocoDB / SeaFile / Wiki.js / Feishu mail) attached at the metadata / file / published-deep-read / IMAP layer. All three inference services and all four subsystems are probed nightly by `update-sources.sh` at 02:30.
 ## Service-down incident (2026-07-17 → ongoing)
 This is the **dominant operational fact** for the theme right now.
 - **Incident start:** Desktop AI service on `192.168.192.67` stopped responding at 2026-07-17. Affected ports: `7997` (LM Studio embed), `8090` (bge-reranker), `11434` (Ollama serve). All three local inference endpoints are simultaneously offline. Documented in [`/sources/2026-07-27-4-27-sop-vs-implementation.md`](/sources/2026-07-27-4-27-sop-vs-implementation.md) §4 (Ollama visual-review degradation).
 - **Operational impact:** LDR SOP Step 4 (Ollama visual review of extracted PDF figures) cannot run — Robin's literature-deep-read pipeline falls back to human-in-the-loop visual review of SeaFile-hosted figures. Cross-agent RAGFlow queries fall back to metadata-only (NocoDB tables, Wiki.js GraphQL, SeaFile file listing) since vector retrieval depends on the embedder and reranker.
 - **Recovery procedure:** documented at `/sources/2026-07-27-4-27-sop-vs-implementation.md` §4 — Robin to run `ollama serve &` and `ollama pull qwen2.5vl:7b` on the desktop, then verify with the `ollama_vision` smoke test in the same file.
 - **Status note:** This is a watchlist item, not a `themes.md` row, because the underlying root cause (desktop service restart) is operational not recurring. Tracked implicitly through the LDR SOP and the daily cron health probe — when RAGFlow's `/api/v1/health` returns 200 and `/api/v1/datasets` returns 401 (auth-only), the KB inventory is still readable; the dependency is on the embed/rerank services for retrieval quality.
 ## RAGFlow KB inventory (18 KB / 32,709 docs / 116,254 chunks)
 Snapshot from [`/sources/ragflow.md`](/sources/ragflow.md) (last sync 2026-08-03T18:30:02Z, landing 200, `/api/v1/health` 404, `/api/v1/datasets` 401 — auth confirmed, retrieval path not exercised since the incident).
 | KB name | Dataset ID (prefix) | Docs | Chunks | Embed model |
 | --- | --- | ---: | ---: | --- |
 | 废弃库 | `daa9ee226765` | 15,922 | 1,604 | nomic-embed-text@Ollama |
 | Organoid1 | `8dfa438274e5` | 7,815 | 8,714 | BAAI/bge-m3@LM-Studio |
 | Organoid2 | `044cdb547620` | 4,974 | 5,888 | BAAI/bge-m3@LM-Studio |
 | Organoid | `3c063ce2559c` | 2,514 | 30,978 | nomic-embed-text@Ollama |
 | 3Brian | `06af5550559d` | 454 | 19,374 | nomic-embed-text@Ollama |
 | Cellink | `cf973e0e559f` | 340 | 26,200 | nomic-embed-text@Ollama |
 | Celvivo | `1555e5b27832` | 154 | 9,027 | BAAI/bge-m3@LM-Studio |
 | RAGFlow | `e3203cec58ff` | 128 | 1,268 | nomic-embed-text@Ollama |
 | FemtoBiomed_electroporation | `c97eb5606aa8` | 123 | 142 | BAAI/bge-m3@LM-Studio |
 | Celvivo1 | `a83244a855c2` | 90 | 4,699 | nomic-embed-text@Ollama |
 | seer | `79bfa1386a26` | 81 | 3,194 | text-embedding-v4@Tongyi-Qianwen |
 | cellshot | `35d3e1bc680c` | 73 | 3,556 | BAAI/bge-m3@LM-Studio |
 | LaminarWash | `1ccc414278d2` | 21 | 1,257 | BAAI/bge-m3@LM-Studio |
 | Celvivo commercial | `922cde0880aa` | 10 | 40 | BAAI/bge-m3@LM-Studio |
 | Cellshot厂家 | `437d31de7a7b` | 5 | 49 | BAAI/bge-m3@LM-Studio |
 | huibaibio | `92604bda7aab` | 3 | 107 | BAAI/bge-m3@LM-Studio |
 | Organoid3 | `29d5de0a7ff5` | 1 | 57 | BAAI/bge-m3@LM-Studio |
 | nanotemper | `496748f66a26` | 1 | 100 | nomic-embed-text@Ollama |
 | **TOTAL** | — | **32,709** | **116,254** | — |
 Embed-model distribution shows the migration story: earlier KBs (Organoid, 3Brain, Cellink, RAGFlow, Celvivo1, nanotemper, 废弃库) were embedded with `nomic-embed-text@Ollama`; later KBs (Organoid1, Organoid2, Celvivo, FemtoBiomed_electroporation, cellshot, LaminarWash, Celvivo commercial, Cellshot厂家, huibaibio, Organoid3) were embedded with `BAAI/bge-m3@LM-Studio`. The `seer` KB is the only one using a non-local embedder (`text-embedding-v4@Tongyi-Qianwen`). This is a real production fleet, not a single notebook.
 ### RAGFlow 0.17 server-side cap (operational note)
 `/sources/ragflow-documents.md` documents that RAGFlow 0.17 server-side caps `/api/v1/documents` to 30 docs per request and silently ignores the `offset` parameter. Coverage in the documents sample:
 - 6 small KBs (≤30 docs): 100% coverage
 - 12 large KBs (>30 docs): only first 30 sampled, no pagination possible from the API alone
 - Total sample: 401 doc-name rows across 18 KBs
 Workaround for full enumeration: read the KB directly through Wiki.js, NocoDB metadata, or the `RAGFlow` doc PDF dump under SeaFile. Documented at [`/sources/ragflow-documents.md`](/sources/ragflow-documents.md) header.
 ## Adjacent NAS subsystems (one-line summaries)
 Each subsystem has its own source page; the bullets below are the cross-agent query affordances.
 ### NocoDB — metadata store
 - **Endpoint:** `http://10.10.10.254:8081` · 13 lit tables · 6,604 records (2026-07-27 snapshot; **`/sources/nocodb.md` last-sync timestamp `$(date -u +%Y-%m-%dT%H:%M:%SZ)` is unrendered** — the cron that wrote the source page left the template unfilled).
 - **Per-table scale** (last full census): `brain_organoid_literature` 103, `intestinal_organoid_literature` 9, `Celvivo_literature` 109, `cardiac_organoid_literature` 11, `cancer_organoid_literature` 129, `liver_organoid_literature` 28, `other_organoid_literature` 724, `kidney_organoid_literature` 23, `retinal_organoid_literature` 4, `Cellink_literature` 2,499 (largest), `organoid_literature` (old) 2,777, `lung_organoid_literature` 48, `3Brain_literature` 147.
 - **API quirk:** Cellink library `已精读` SingleSelect `options=[]` (NocoDB bug) — cannot PATCH "是". Documented at [`/sources/2026-07-27-4-27-sop-vs-implementation.md`](/sources/2026-07-27-4-27-sop-vs-implementation.md) §3. Workaround: write 精读摘要 + 精读日期 to PATCH-able fields; mark `已精读 = 是` via the wiki synthesis layer instead.
 - **Cross-link:** [`/sources/nocodb.md`](/sources/nocodb.md)
 ### SeaFile — large-file storage
 - **Endpoint:** `http://10.10.10.254:9898/api2/` · public domain `https://fb.biokingdom.top` for share-links · 4 repos / 77 GB total.
 - **API quirk:** port 5000 is the Web UI reverse proxy, **not** the API. Token auth via `Authorization: Token ***` header. Share-link `?dl=1` suffix is required for direct download.
 - **Daily use:** LDR SOP Step 5 uploads PDF + 3 extracted figures → SeaFile → embeds `![]()` markdown in Obsidian / Wiki.js / OpenWiki. Documented at [`/sources/ldr-report-template.md`](/sources/ldr-report-template.md) §4 and §5.
 - **Cross-link:** [`/sources/seafile.md`](/sources/seafile.md)
 ### Wiki.js — published deep-read layer
 - **Endpoint:** `http://10.10.10.254:3000/graphql` · estimated ≥ 1,648 pages (based on max page id 1633) · zh/literature subpath is the primary publishing target.
 - **API quirk:** `pages.list(limit:N)` server-side caps to ~50 regardless of N; real count requires 5-orderBy union (TITLE / UPDATED / CREATED / ID / PATH) — documented at [`/sources/wikijs.md`](/sources/wikijs.md) header. The "47" number from earlier 7-27 evidence is a server-side cap artifact, not the true count.
 - **Daily use:** LDR SOP Step 7 publishes deep-read reports to Wiki.js for cross-device / customer-facing reading. Maintenance is owned by `wikijs-obsidian-sync` skill (Robin + LDR auto-publish).
 - **Cross-link:** [`/sources/wikijs.md`](/sources/wikijs.md)
 ### Feishu mail — IMAP polling (awaiting credentials)
 - **Endpoint:** `imap.feishu.cn:993` (CN) or `imap.larksuite.com:993` (INTL) · `LOGIN` auth · 16-char app password required.
 - **Status:** script `~/.local/bin/openwiki-update-feishu-mail.sh` is drafted (Robin 2026-07-29 spec); cron entry `*/30 * * * *` is not yet in `crontab`. Page at [`/sources/feishu-mail.md`](/sources/feishu-mail.md) is intentionally blank pending credentials.
 - **Operational rule (Robin 7-28):** Feishu mailbox **is not** the same as Gmail — `openwiki auth google` does not reach it. Feishu needs a separate IMAP credentials path through `~/.openwiki_env.sh`.
 - **Cross-link:** [`/sources/feishu-mail.md`](/sources/feishu-mail.md)
 ## Daily operations
 Two cron pipelines drive the local-LLM fleet:
 ```mermaid
 flowchart LR
    subgraph Cron1["02:00 daily · openwiki-update.sh"]
        HN[Hacker News ingest]
        Tavily[Tavily web search ingest]
        GitRepo[git-repo ingest]
        M3["M3 agent synthesis (writes /themes + /commitments)"]
    end
    subgraph Cron2["02:30 daily · openwiki-update-sources.sh"]
        NocoDBP[NocoDB count refresh]
        SeaFileP[SeaFile count refresh]
        WikiJSP[Wiki.js count refresh]
        RAGFlowP[RAGFlow health probe]
    end
    subgraph Cron3["*:30 daily · openwiki-update-feishu-mail.sh (waiting)"]
        FeishuP[Feishu INBOX poll]
    end
    subgraph Runtime["Local inference runtime"]
        OllamaEmbed["Ollama :11434 (nomic-embed-text)"]
        LMStudioEmbed["LM Studio :7997 (BAAI/bge-m3)"]
        RerankerSvc["bge-reranker :8090"]
    end
    subgraph Sink["Wiki sink"]
        OpenWiki[OpenWiki (commit and push Gitea)]
    end
    Cron1 --> OpenWiki
    Cron2 --> OpenWiki
    Cron3 -.future.-> OpenWiki
    RAGFlowP -.depends on.-> OllamaEmbed
    RAGFlowP -.depends on.-> LMStudioEmbed
    RAGFlowP -.depends on.-> RerankerSvc
 ```
 The 02:00 cron pulls 3 connectors and runs M3 agent synthesis (writes to `/themes/` and `/commitments/`). The 02:30 cron pulls counts from the 4 NAS subsystems. The 30-min Feishu cron is queued but inactive until IMAP creds land. After each cron, OpenWiki commits and pushes to the Gitea public mirror.
 - **Health check:** `~/.local/bin/openwiki-update-sources.sh` probes each NAS subsystem's API; on success the source page is rewritten; on failure the previous good state remains.
 - **Cross-agent query:** Hermes / MiniMax code reads `sources/{ragflow,nocodb,seafile,wikijs,feishu-mail}.md` to discover "what's in this system" without an SQL/GraphQL round-trip; the 4 OpenWiki bridge skills route the cross-agent queries (see [`/themes/03-ai-agents.md`](/themes/03-ai-agents.md) §"MiniMax code").
 ## Cross-cutting relationship
 - **Consumed by [`/themes/03-ai-agents.md`](/themes/03-ai-agents.md)** — every Hermes / MiniMax code / Codex call depends on the local LLM fleet (Ollama / bge-reranker / RAGFlow). The 2026-07-17 desktop service-down incident is the live dependency that breaks the cross-agent workflow.
 - **Hosts the evidence layer for [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md), [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md), and [`/themes/05-robin-research.md`](/themes/05-robin-research.md)** — RAGFlow KBs (Celvivo / 3Brian / Cellink / Organoid1-3 / etc.) are the deep retrieval surface behind every vendor deep read; NocoDB is the metadata catalog; Wiki.js is the public publishing target.
 - **Privacy rule (Robin 7-28):** Feishu mailbox is **not** Gmail. The `/sources/feishu-mail.md` page exists precisely to prevent future agents from trying `openwiki auth google` against it. Permanent memory record.
 ## Backlog for this theme
 - **Bring desktop AI service back up** — restart `ollama serve` + `ollama pull qwen2.5vl:7b` + LM Studio + bge-reranker on `192.168.192.67`. Without this, the LDR SOP visual review step is degraded and RAGFlow vector retrieval is metadata-only.
 - **Fix NocoDB `/sources/nocodb.md` unrendered timestamp** — the page contains literal `$(date -u +%Y-%m-%dT%H:%M:%SZ)` in the header; needs the cron template to actually substitute the variable. Documented but not yet fixed at the source page level.
 - **SeaFile source-page library-name template** — `/sources/seafile.md` has 6 library rows with `?` placeholders for ID / size / file count / last update; the upstream `update-sources.sh` is not filling them. Either fix the script or remove the table.
 - **RAGFlow `废弃库` (15,922 docs / 1,604 chunks) cleanup question** — Robin 7-27 said "永久不动". Currently the largest KB by doc count but only the 4th-largest by chunk count. Surface again only if Robin changes stance; do not auto-clean.
 - **Wiki.js ≥ 1,648 page real count** — server-side cap of ~50 in `pages.list(limit:N)` is a known RAGFlow 0.17-style artifact. Full enumeration requires either a Wiki.js DB-direct query or a frontend crawler. Documented as a known limitation in [`/sources/wikijs.md`](/sources/wikijs.md).
 - **Feishu IMAP integration** — script drafted; awaiting Robin IT to enable IMAP/SMTP and provide a 16-char app password. Once landed, `crontab` adds `*/30 * * * *` entry and `/sources/feishu-mail.md` starts receiving real evidence rows.
 ## What to read next
 | Question | Go to |
 | --- | --- |
 | What is the RAGFlow KB inventory? | [`/sources/ragflow.md`](/sources/ragflow.md) |
 | What does each RAGFlow KB actually contain (sample docs)? | [`/sources/ragflow-documents.md`](/sources/ragflow-documents.md) |
 | What are the 13 NocoDB lit tables? | [`/sources/nocodb.md`](/sources/nocodb.md) |
 | What is in SeaFile? | [`/sources/seafile.md`](/sources/seafile.md) |
 | What is in Wiki.js? | [`/sources/wikijs.md`](/sources/wikijs.md) |
 | What is the Feishu mail integration status? | [`/sources/feishu-mail.md`](/sources/feishu-mail.md) |
 | How are the LDR PDFs and figures uploaded to SeaFile? | [`/sources/ldr-report-template.md`](/sources/ldr-report-template.md) §4-5 |
 | What did the 7-27 SOP-vs-implementation pass reveal about the service-down incident? | [`/sources/2026-07-27-4-27-sop-vs-implementation.md`](/sources/2026-07-27-4-27-sop-vs-implementation.md) §4 |
 | What is the daily cron pipeline? | [`/README-ACTIVATION.md`](/README-ACTIVATION.md) §3 |
 | How does MiniMax code read this stack? | [`/sources/OpenWiki速查手册.md`](/sources/OpenWiki速查手册.md) §5.8 |
 | How does the agent layer depend on this fleet? | [`/themes/03-ai-agents.md`](/themes/03-ai-agents.md) |
@@ -0,0 +1,417 @@
 ---
 type: "Reference"
 title: "Theme 5 · Robin's personal research (vendor deep reads + sales ammunition + CRM)"
 description: "Synthesis page for Robin's personal research portfolio — Obsidian vault + literature deep-read pipeline + sales ammunition + China distributor map + active CRM profiles + work-rhythm snapshots. Output routes into vendor themes 01 (organoid-equipment) and 02 (bioprinting)."
 tags: [theme, research, vault, deep-read, sales, crm, life-sciences, 2026-08-22, 2026-08-21, 2026-08-20, 2026-08-19, 2026-08-18, 2026-08-17, 2026-08-15, 2026-08-13]
 timestamp: 2026-08-22T18:13:00Z
 ---
 # Theme 5 · Robin's personal research (vendor deep reads + sales ammunition + CRM)
 This is the synthesis page for **Robin 个人研究项目** — the durable body of work Robin builds on the 4-vendor product line: vendor-paper deep reads, vendor whitepaper deep reads, sales ammunition (pricing + protocols + app notes), the China distributor map, the active CRM profile set, and the weekly work-rhythm snapshot. Output is fed back into the vendor themes ([`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) and [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md)) and into `/commitments.md`.
 ## What this theme covers
 - **Research identity & scope:** 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed) + adjacent application domains (MSC spheroids, PDO, brain organoids, hMOs, assembloids, 3D bioprinting, electroporation).
 - **Knowledge substrate:** Obsidian vault rooted at `/mnt/c/Users/20864/.openclaw/workspace` (per `~/.openwiki/connectors/git-repo/config.json`), HEAD `1a81e485`, ahead of origin/main by 9 commits.
 - **Research process:** LDR master template + SOP-vs-implementation lessons (Tasevska / Raji / Bosnjakovic as canonical worked examples).
 - **Research output:** 1,202 deep-read notes in `04-Literature/Deep-Reads/` + sales training material in `06-Sales/Content/Training-Materials/` + active CelVivo industrial-customers program.
 - **CRM + market research:** 1 active distributor profile (`02-Clients/Agents/董慧群.md`) + 261-dealer China map + 11+ end-customer dossiers under `03-Resources/End-Customers/`.
 - **Work-rhythm evidence:** 2026-07-16 vault mtime snapshot showing Robin's actual activity cadence across deep reads / training material / daily / weekly reports.
 ## Research output — data model
 ```mermaid
 erDiagram
    VAULT["Obsidian vault (a4fa5a32)"] ||--o{ DEEPREADS["Deep-read notes ~1,207"]
    VAULT ||--o{ TRAIN["Sales training (CelVivo赋能培训 v1-v9)"]
    VAULT ||--o{ SALES["Active sales pipeline (惠百生物 PO + 中间商)"]
    VAULT ||--o{ CRM["Distributor profiles (董慧群 + 待补)"]
    VAULT ||--o{ ENDCUST["End-customer dossiers (11+ 神经/中药/肿瘤所)"]
    VAULT ||--o{ INDUSTRIAL["Industrial customers (CelVivo中国工业客户开发)"]
    VAULT ||--o{ MEMORY["Daily + weekly reports (memory/ 147 .md)"]
    VAULT ||--o{ ITX["ITX 24h host build (untracked)"]
    VAULT ||--o{ MOC["MOCs (类器官与3D培养 first, +planned)"]
    VAULT ||--o{ TEMPLATES["Templates (类器官IRB申请清单 v1.0, untracked)"]
    DEEPREADS }o--|| VENDOR["Vendor mapping"]
    VENDOR ||--|{ CelVivo["CelVivo (ClinoStar / ClinoReactor)"]
    VENDOR ||--|{ ThreeBrain["3Brain (BioCAM / Accura-3D / CorePlate)"]
    VENDOR ||--|{ Cellink["Cellink (BIO X / BIONOVA X / Lumen X)"]
    VENDOR ||--|{ Femtobiomed["Femtobiomed (CellShot / TriArm / CellPick)"]
    SALES }o--|| CelVivo
    CRM }o--|| CelVivo
    ENDCUST }o--|| ThreeBrain
    INDUSTRIAL }o--|| CelVivo
    TRAIN }o--|| CelVivo
 ```
 The diagram shows Robin's research substrate: a single Obsidian vault with 8 buckets of artifacts, most of which are vendor-anchored to one of the 4 product lines. Vendor-anchored output flows out of the vault and into the canonical synthesis themes (`01` CelVivo / 3Brain; `02` Cellink; with Femtobiomed as adjacent cross-sell for both).
 ## Knowledge substrate: Obsidian vault
 Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08-22T18:13:00Z):
 | Field | Value |
 | --- | --- |
 | Repo path | `/home/ldw/workspace` |
 | Branch | `main` |
 | HEAD | `a4fa5a323d6dcabeb9eccad49e636ee6ba5f87a6` (**unchanged** at the 2026-08-22T18:13Z fetch — **0 new vault commits** in the 2026-08-21T18:09Z → 2026-08-22T18:13Z 24-hour window; vault is silent for the **6th consecutive fetch** after the 2026-08-17T18:09Z + 2026-08-18T18:10Z + 2026-08-19T18:08Z + 2026-08-20T18:09Z + 2026-08-21T18:09Z silent windows; **6 calendar days stale** since the last vault HEAD bump on 2026-08-16; the 2026-08-16 Quintard 2024 Nat Commun 4-commit LDR cycle + Guo 2026 Front Cell Dev Biol 3-commit LDR cycle remain the most recent vault activity) |
 | Ahead of origin/main | 20 commits new since 2026-08-03 fetch (unchanged from the 2026-08-17 + 2026-08-18 + 2026-08-19 + 2026-08-20 + 2026-08-21 + 2026-08-22 fetches) |
 | Auth | local path only — no remote, no credentials |
 | Working-tree state | dirty (23 untracked files + 2 new untracked directories — `celvivo_commercial/1331651_20260630_131201.pdf` + `templates/类器官IRB申请清单.md` — both untracked; the `Review/zhou2023_computer_vision_microfluidics.md` first-entry-in-Review/-subfolder is still-uncommitted, carrying forward from the 2026-08-13 fetch, **11-day carry-forward** at the 2026-08-22T18:13Z fetch — **9 fetches silent** on the file) |
 | Raw manifest | `~/.openwiki/connectors/git-repo/raw/2026-08-22T18-13-00-193Z/manifest.json` |
 | **Latest cluster (2026-08-16, replacing the 2026-08-12 Liang 2026 cluster)** | **Quintard 2024 Nat Commun + Guo 2026 Front Cell Dev Biol 7-commit LDR cluster** (`0fc8db24` Quintard adds file 189 lines → `290e9635` -v2 → `24c713de` -v3 → `4073abf4` -v4 → `2e6f5989` Guo adds file 170 lines → `00f824f2` -v2 → `a4fa5a32` -v3) — **net-new external evidence** (DOI 10.1038/s41598-026-42990-2, PMID 41857098, mouse liver 3-轨道 Hep-Orgs + Cho-Orgs + HSC + DAPT+Dex P1-P10 长程成熟 + TGFβ 激活体外纤维化模型) |
 | **Latest uncommitted artifact (2026-08-13 → 2026-08-22, multi-file, unchanged at the 2026-08-22T18:13Z fetch)** | `04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md` (carry-forward untracked from 2026-08-13, now at **11-day carry-forward** at the 2026-08-22 fetch — file mtime `2026-08-11 16:31:54 +0800` so mtime-based carry-forward is 11 days; first-observation-date-based carry-forward is 9 days; **structural signal continuing to weaken** per `/sources/git-repo.md` Notable-entity entry — 9 consecutive fetches silent on the file; subfolder is more likely a one-off than a recurring pattern) + **2 new untracked directories added at the 2026-08-17 fetch**, still-uncommitted at the 2026-08-22 fetch (**6-day carry-forward** each — was 5-day at the 2026-08-21 fetch): `celvivo_commercial/1331651_20260630_131201.pdf` (6-30 quote PDF migrated into new folder) + `templates/类器官IRB申请清单.md` (180-line IRB application checklist derived from Guo 2026; Robin's first customer-facing template produced from a single deep-read — see the new Templates subtree below) |
 ### Vault navigation index (top-level folders)
 | Dir | Purpose | Size hint |
 | --- | --- | --- |
 | `01-Active-Sales/` | Active sales pipeline (board + per-account) | 6 .md |
 | `02-Active-Deals/` | Deal-level active docs | 1 .md |
 | `02-Clients/`, `02-Contacts/` | Client & contact records | sparse |
 | `03-Product/` | Product briefs (e.g. 3Brain-Maxwell comparison) | 1 .md |
 | `03-Resources/Agents/` | Distributor / agent profiles | a handful |
 | `03-Resources/End-Customers/` | End-customer dossiers (3Brain MEA accounts, etc.) | 11+ .md |
 | `03-Resources/ITX-24h-Host/` | Personal 24h Hermes-Agent host build config (2026-07-31 untracked) | 1 .md |
 | `04-Literature/` | Paper deep-reads + curated vendor PDFs | see breakdown below |
 | `05-Documents/Contracts/` | Signed/pending contracts (Celvivo subfolder) | — |
 | `05-Documents/Products/` | Vendor-facing product docs (Celvivo/Industrial-Customers) | — |
 | `05-Documents/{Proposals,Quotes,Visit-Plans}/` | Active commercial docs | — |
 | `05-Products/` | In-house product briefs (MappingLab family) | 2 .md |
 | `06-Sales/Competitors/` | Competitor tracking | — |
 | `06-Sales/Configurations/` | Product configurations | — |
 | `06-Sales/Content/{FAQ,Pain-Points,PPT-Scripts,Success-Stories,Training-Materials,推文模板}/` | Sales content library | — |
 | `06-Sales/{Price-List,Product-Mapping,Recommendation-Engine}/` | Sales tooling | — |
 | `99-Templates/` | Reusable Obsidian templates | 14 .md |
 | `memory/` | Daily reports, weekly digests, `.dreams`, archive | 147 .md |
 ### `04-Literature/Deep-Reads/` breakdown
 | Subfolder | .md count | Vendor / scope |
 | --- | ---: | --- |
 | `Organoid/` | 661 (+2 from 2026-08-16 — Quintard 2024 Nat Commun microfluidic vascularized organoid chip + Guo 2026 Front Cell Dev Biol organoid ethics systematic review) | broad organoid literature |
 | `Celvivo/` | 142 | CelVivo vendor + CelVivo-adjacent papers |
 | `3Brain/` | 136 | 3Brain vendor + 3Brain-adjacent papers |
 | `Cellink/` | 129 | Cellink vendor + Cellink-adjacent papers |
 | `Organoid-List/` | 51 | curated organoid reading lists |
 | `Product-Reports/` | 38 | vendor product reports |
 | `Brain/` | 11 | brain organoid focus |
 | `Brain-Tumor/` | 9 | brain tumor organoid |
 | `Cancer/` | 6 | cancer organoid |
 | `Liver/` | 7 | liver organoid / HepG2 (Liang 2026 4-commit LDR cycle 2026-08-12) |
 | `Other/` | 6 | uncategorised |
 | `RegenMed/` | 1 | Ronawk Bio-Block MSC 4-week (added 2026-07-28) |
 | `3Brain MEA/` | 3 | 3Brain HD-MEA papers |
 | `Cardiac/` | 2 | cardiac organoid |
 | `Kidney/` | 2 | kidney organoid |
 | `Retinal/` | 1 | retinal organoid |
 | `Microbioreactor/` | 1 | Rosero 2026 Front Bioeng Biotechnol (added 2026-08-07) |
 | `Cells/` | 1 | Fernandez Vallone 2026 Cells THSDC (added 2026-08-08) |
 | `Review/` | 1 | Zhou 2023 computer vision + microfluidics (added 2026-08-13, **untracked**, **10-day carry-forward** at 2026-08-21 fetch (was 9-day at 2026-08-20) — **8 fetches silent** — structural signal continuing to weaken; **11-day carry-forward** at 2026-08-22 fetch — **9 fetches silent**) |
 | `Templates/` | 1 | `类器官IRB申请清单.md` v1.0 (2026-08-16, derived from Guo 2026 ethics deep-read, **untracked**; first customer-facing template produced from a single deep-read; **5-day carry-forward** at 2026-08-21 fetch — was 4-day at 2026-08-20; **6-day carry-forward** at 2026-08-22 fetch) |
 | `CelVivo-commercial/` | 1 | `1331651_20260630_131201.pdf` (2026-06-30 quote PDF migrated into new folder 2026-08-17, **untracked**; **5-day carry-forward** at 2026-08-21 fetch — was 4-day at 2026-08-20; **6-day carry-forward** at 2026-08-22 fetch) |
 Total ≈ 1,206 deep-read notes on `main` + **1 untracked entry in the new `Review/` subfolder** (`zhou2023_computer_vision_microfluidics.md`, 2026-08-13 — first review-type subfolder; future-commit candidate) + **2 new untracked directories** (`templates/类器官IRB申请清单.md` + `celvivo_commercial/1331651_20260630_131201.pdf`, 2026-08-17). The 4 vendor subfolders (Celvivo / 3Brain / Cellink / Organoid) cover the canonical product KB per the wiki goal focus areas. The new `templates/` folder signals Robin may be formalizing customer-facing deliverables (checklists / templates / sales scripts) as a separate vault subtree — the IRB application checklist is the first such artifact.
 ## Literature deep-read (LDR) pipeline
 The 4-27 SOP (referenced from `/sources/ldr-report-template.md` and `/sources/2026-07-27-4-27-sop-vs-implementation.md`) is the canonical research workflow Robin uses to convert a vendor-paper PDF into a publishable, indexed, cross-system deep read.
 ```mermaid
 stateDiagram-v2
    [*] --> PubmedVerify: Id / DOI / PMID / PDF
    PubmedVerify --> PDFPull: PubMed eSummary 验真
    PDFPull --> ImgExtract: ragflow_direct_download.py / direct path
    ImgExtract --> VisionReview: PyMuPDF xref dedup + 30KB + p1 logo
    VisionReview --> ReportWrite: Ollama qwen2.5vl:7b (降级 if 服务宕)
    ReportWrite --> SeaFileUpload: 5 段模板 (做了什么 / 3 发现 / 4 维对接 / 局限 / 转发语)
    SeaFileUpload --> WikiPublish: PDF + 3 真图 → ?dl=1
    WikiPublish --> NocoDB: GraphQL 5-orderBy union
    NocoDB --> Commit: NocoDB v1 + JSON body (PATCH preferred)
    Commit --> [*]: OpenWiki git commit + Gitea push
    note right of VisionReview
      2026-07-17 起 Ollama 服务宕
      视觉审核降级 → 人工肉眼
    end note
    note right of NocoDB
      Cellink 库 "已精读" SingleSelect options=[]
      PATCH 失败, 在精读摘要里写
    end note
 ```
 The state diagram shows the canonical LDR pipeline: PDF → images → report → SeaFile → Wiki.js → NocoDB → commit. Two known operational degradations are called out: the Ollama visual-review step falls back to human review since 2026-07-17 (see [`/themes/04-local-llm.md`](/themes/04-local-llm.md)), and the Cellink library `已精读` SingleSelect is a NocoDB bug that blocks PATCH (workaround documented in the SOP-vs-implementation file).
 ### LDR SOP — 8 铁律 + 3 trigger modes + 5-section report
 From [`/sources/ldr-report-template.md`](/sources/ldr-report-template.md) (Robin 7-27 实战版):
 | 铁律 | 出处 | 实操 |
 | --- | --- | --- |
 | 1. PDF 全文必传 (SeaFile 永久链接, `?dl=1` 后缀) | 7-27 教训 | `upload.py` 上传 PDF, `?dl=1` 写 link |
 | 2. PyMuPDF xref 去重 + 30KB 过滤 + p1 logo 剔除 | 7-27 教训 (Tasevska p1 logo) | `extract_image(xref)` per page, MD5 dedup |
 | 3. 9 项强制 + 创新点/局限性/学术启示 3 段 | 7-27 教训 (2 篇缺 3 段) | 模板 §3 |
 | 4. SeaFile URL hostname `fb.biokingdom.top` | 7-27 教训 (5 URL 错) | 验证 share-link 真能开 |
 | 5. NocoDB v1 + JSON body (范本 v2 失败 3 次) | 7-27 Tasevska 入库 | `POST /api/v1/db/data/wzg1wtad/p2z4g0s687axyvu/{table_id}` |
 | 6. 3 张真图 `![]()` (SeaFile URL), 不**只**文字图说啥 | 7-27 教训 | markdown image syntax (`alt text` + parenthesized URL) |
 | 7. 报告路径 `journal-year-topic` (4-27 SOP 范本) | 7-27 教训 | `ejps-2025-hctz-sse-3d-printing` 风格 |
 | 8. 精简 4 步 vs 完整 8 步按 Robin 信号自动判断 | 7-27 实战 | 模板 §2 |
 **3 trigger modes:**
 | Robin says | I take | 耗时 |
 | --- | --- | --- |
 | "精读吧" (any PDF, no publish intent) | **精简 4 步** (PDF → PyMuPDF → 写报告 → Obsidian) | 20-30 min |
 | "A" / "发 wikijs" / "SeaFile 永久" / "入库" / "NocoDB" | **完整 8 步** (精简 4 步 + Ollama 视觉 + SeaFile + Wiki.js + NocoDB) | 45-60 min |
 | "X 还是 Y" / "你定" / "继续下一篇" | **自动** | — |
 **5-section report template (800–1500 chars):** 1. 做了什么 / 2. 3 关键发现 (每发现 3 段式表) / 3. 4 维产品对接 (CelVivo / 3Brain / Cellink / Femtobiomed) / 4. 局限 / 5. 转发语 + 落款 + PDF.
 ### Worked examples (canonical deep reads)
 | Deep read | Vendor | Path | Synthesized at |
 | --- | --- | --- | --- |
 | Bosnjakovic 2025 bioRxiv | CelVivo | `04-Literature/Deep-Reads/Celvivo/Bosnjakovic_2025_PAH_3D_spheroid_CelVivo_ClinoStar_2026-07-27.md` | [`/sources/literature-cel-bosnjakovic-2025-pah-deepread.md`](/sources/literature-cel-bosnjakovic-2025-pah-deepread.md) |
 | Raji 2026 Mol Psychiatry | 3Brain | `04-Literature/Deep-Reads/3Brain/Raji_2026_hMOs_dopaminergic_3Brain_MEA_2026-07-27.md` | [`/sources/literature-raji-2026-deepread.md`](/sources/literature-raji-2026-deepread.md) |
 | Tasevska 2025 EJPS | Cellink | `04-Literature/Deep-Reads/Cellink/Tasevska_2025_HCTZ_3D_printed_extended_release_2026-07-27.md` | [`/sources/literature-tasevska-2025-deepread.md`](/sources/literature-tasevska-2025-deepread.md) |
 | CelVivo 2026 brain organoid whitepaper (16 pp) | CelVivo | under `04-Literature/Deep-Reads/Celvivo/` | [`/sources/literature-celvivo-brain-whitepaper-2026.md`](/sources/literature-celvivo-brain-whitepaper-2026.md) |
 | Hodge 2025 RegenMed | Ronawk Bio-Block (KB 0 命中) | `04-Literature/Deep-Reads/RegenMed/2026-07-28_Hodge_2025_RegenMed_MSC_3D_Bio-Block.md` | (not yet synthesized to `/sources/`) |
 | Lee 2025 Front Vet Sci | (no vendor) | `04-Literature/Deep-Reads/Other/2026-07-28_Lee_2025_FrontVetSci_canine_MSC_3D_spheroid.md` | (not yet synthesized) |
 | Parate 2020 SCRT | (no vendor) | `04-Literature/Deep-Reads/Other/2026-07-28_Parate_2020_SCRT_PEMF_MSC_paracrine_cartilage.md` | (not yet synthesized) |
 | Sharma 2026 Cell Stem Cell (2026-08-08 flywheel-sync) | 3Brain + CelVivo adjacent | `/home/ldw/workspace/retinal_organoid_deep_read_2026-08-07.md` | [`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`](/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md) |
 | Miao 2025 Cell v2 (2026-08-08 flywheel-sync) | CelVivo (ClinoStar rating 5) | `/home/ldw/workspace/Miao2025_Cell_v2.md` | [`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`](/sources/literature-miao-2025-cell-vascularization-v2-deepread.md) |
 | Liu 2026 Nat Biomed Eng (2026-08-08 flywheel-sync) | 3Brain (HD-MEA rating 5) + Cellink (microlattice rating 5) | `/home/ldw/workspace/Liu2026_NBME_shape_conformal_organoid.md` | [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md) |
 | Quintard 2024 Nat Commun (2026-08-16 vault LDR cluster) | CelVivo (ClinoStar rating 3 upstream) + Mimetas OrganoPlate (rating 4 direct) + Emulate Organ-Chip (rating 3) | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` | (not yet synthesized to `/sources/`) |
 | Guo 2026 Front Cell Dev Biol (2026-08-16 vault LDR cluster) | CelVivo (ClinoStar rating 4 clinical-translation IRB) + Mimetas OrganoPlate (rating 4 co-culture ethics) + Emulate Organ-Chip (rating 3) | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` | (not yet synthesized to `/sources/`; derived customer-facing template at `templates/类器官IRB申请清单.md` v1.0) |
 ## Recent 30-day research output (mtime 2026-06-16 → 2026-08-12)
 From [`/sources/literature.md`](/sources/literature.md) last sync, broken out by vendor and date:
 | Date | DOI / slug | Vendor | Topic |
 | --- | --- | --- | --- |
 | 2026-08-16 | **Quintard 2024 Nat Commun + Guo 2026 Front Cell Dev Biol 7-commit LDR cluster** (commits `0fc8db24` + `290e9635` + `24c713de` + `4073abf4` Quintard + `2e6f5989` + `00f824f2` + `a4fa5a32` Guo) | **CelVivo adjacent + Mimetas OrganoPlate ⭐⭐⭐⭐ + Emulate Organ-Chip ⭐⭐⭐** (Quintard) / **CelVivo ClinoStar ⭐⭐⭐⭐ + Mimetas OrganoPlate ⭐⭐⭐⭐ + Emulate Organ-Chip ⭐⭐⭐** (Guo) | Quintard C et al. (2024) A microfluidic platform integrating functional vascularized organoids-on-chip (Nat Commun DOI 10.1038/s41467-024-45710-4, Wiki ID 1719/1720/1722, NocoDB Id 3297; 10 通道并行微流控 + hiPSC-BVO 30 天功能性灌注培养 + 跨类器官验证 [间充质球体 / BVO / 胰岛球体 / 肺类器官]; 血管层级化 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管, 壁剪切 27-2000 s⁻¹, 完美匹配人体毛细血管生理范围 50-1900 s⁻¹) + Guo Z & Zhang N (2026) Ethical review key considerations for organoid applications in biomedical research—a systematic review (Front Cell Dev Biol DOI 10.3389/fcell.2026.1721946, Wiki ID 1724, NocoDB Id 3298; 嘉兴市第一医院 + 嘉兴大学医学院视角; 类器官研究 IRB / 伦理审查 7 大强制要点系统综述 [样本来源/知情同意/数据隐私/共培养主体性/3R 动物福利/跨境监管/长期保存与终止使用] + 中国《人类遗传资源管理条例》+ 国际 ISSCR/GDPR/HIPAA 多国对照表). **Robin translated Guo 2026 into a customer-facing IRB application checklist template** (`templates/类器官IRB申请清单.md` v1.0 180 lines) — first customer-facing template produced from a single deep-read. |
 | 2026-08-12 | **Liang 2026 liver organoid fibrosis platform 4-commit LDR cycle** (commits `e542c977` + `8699a154` + `aacba7aa` + `297f106d`) | **CelVivo (ClinoStar rating 5 + ClinoReactor rating 5)** | Liang Y et al. (2026) A robust mouse liver organoid platform enables sustained multicellular maturation and fibrosis modeling from a single tissue sample (Sci Rep DOI 10.1038/s41598-026-42990-2, PMID 41857098; Wiki.js Id 1716, NocoDB Id 770; 3 轨道 Hep-Orgs + Cho-Orgs + HSC 同步分离; DAPT+Dex P1-P10 长程稳定成熟 [ALB/PAS/LDL/CYP 跨代保持]; TGFβ 激活 qHSC → aHSC [Acta2/Col1a1 上调]; aHSC 共培养诱导 Hep-Orgs EMT [Snail/Twist/Vimentin↑; ALB/CK8↓; Lgr5/EpCAM↓; Ki67↓] = 体外肝纤维化模型) — page 946 9 项 SOP 重写版 + page 934 修齐 标杆; 7/7 Ollama qwen2.5vl 视觉审核通过; SeaFile 7/7 公网 200 验真. First paper whose `related:` field already names `[[MOC-类器官与3D培养]]` (the 2026-08-10 first MOC) on the day of publication. |
 | 2026-08-10 | **Phase A metadata batch + first MOC** (commits `d97b39ed` + `6b717aef` + `3b929c2f`) | (process discipline) | 6 deep-reads received the 6-field frontmatter (doi/journal/year/volume/pages/authors/pmid); first MOC `MOC-类器官与3D培养.md` (95 lines, 沙牛《AI 时代的 Obsidian 公开课》课时 1 pattern) created at `04-Literature/Deep-Reads/MOCs/`; 7 image alt descriptions added on `wang2024-org-on-chip.md`. No new external evidence. |
 | 2026-08-09 | `10.7150/thno.90492` (Wang 2024) | (4 类共性硬件 — Organoid-on-Chip 综述) | Wang H et al. (2024) Human organoids-on-chips for biomedical research and applications (Theranostics 14(2):788-818, PMID 38169573; 7 图覆盖 7 大主题板块) — Wiki.js ID 1700 (v2 - grp:3 ghost page 累加) |
 | 2026-08-08 | `10.3390/cells15110963` (Fernandez Vallone 2026) | (NAMs adjacent, hiPSC brain organoid) | THSDC chemical evaluation platform using hiPSC brain organoids (Cells, v2 5 张真图 + 双 H1; Wiki.js Id 1698) |
 | 2026-08-08 | `10.3389/fbioe.2026.1854988` (Rosero 2026) | CelVivo + Cellink + FemtoBiomed adjacent | Microbioreactor design Mini Review (Front Bioeng Biotechnol; 6× productivity vs T-flask; 4 applications: CAR-T / mAb / iPSC / organoid) |
 | 2026-08-08 | `10.1038/s41551-026-01620-y` (Liu 2026) | 3Brain (HD-MEA rating 5) + Cellink (microlattice rating 5) | Shape-conformal porous framework for full-coverage neural organoid e-phys — Rogers Lab, Nat Biomed Eng |
 | 2026-08-08 | `10.1016/j.cell.2025.05.041` (Miao 2025 v2) | CelVivo (ClinoStar rating 5) | Co-development mesoderm+endoderm for vascularized lung/gut organoids (Cell v2) |
 | 2026-08-08 | `10.1016/j.stem.2025.12.013` (Sharma 2026) | 3Brain (HD-MEA rating 4) + CelVivo (ClinoStar rating 3) | Vascularized retinal organoid RGC survival (Cell Stem Cell) |
 | 2026-08-06 | `10.1038/s41467-024-44732-2` (Parfitt 2024) | CelVivo + 3Brain adjacent | DJ1 LOF midbrain organoid PD model — α-syn via astrocyte lysosomal degradation (Nat Commun, untracked) |
 | 2026-07-29 | Organoids for disease modeling and treatment 2026 综述 (PMID 41545895, PMC12828948) | review | Exp Hematol Oncol 2026 — 190 项临床试验 + 4 大瓶颈 |
 | 2026-07-28 | `10.1080_17460751.2025.2572177` (Hodge 2025) | Ronawk Bio-Block | MSC longevity 4-week comparison |
 | 2026-07-28 | `10.3389/fvets.2025.1500267` (Lee 2025) | (no vendor) | canine adipose MSC 3D spheroid |
 | 2026-07-28 | `10.1186_s13287-018-1085-9` (Komatsu 2018) | CelVivo + Cellink | Type I collagen + YAP/TAZ |
 | 2026-07-28 | `10.1186_s13287-020-1566-5` (Parate 2020) | (no vendor) | PEMF potentiate MSC paracrine cartilage |
 | 2026-07-27 | `Raji_2026_hMOs` | 3Brain | hMOs dopaminergic + HD-MEA |
 | 2026-07-27 | `Tasevska_2025_HCTZ` | Cellink | SSE-printed HCTZ extended-release |
 | 2026-07-17 | `260528_CS_vs_OS` appnote | CelVivo | ClinoStar vs Orbital Shaker shear stress |
 | 2026-07-17 | `111_Planimetry` appnote | CelVivo | FIJI planimetry on ClinoReactor |
 | 2026-07-05 | `10.1002_btpr.2528` | CelVivo | Spheroid dissociation device |
 | 2026-06-25 | `10.1016_j.stemcr.2025.102646` | CelVivo | High-throughput microfluidic organoid-on-a-chip |
 | 2026-06-24 | `10.1021_acsomega.5c02682` | 3Brain | rotating human melanoma cell culture |
 | 2026-06-24 | `10.1016_j.xpro.2025.103923` | CelVivo | Lung Tumoroids protocol |
 | 2026-06-23 | `10.1002_jbm4.10792` | CelVivo | microfluidic organoid-on-a-chip (v2-munir2023) |
 | 2026-06-23 | `10.3390_cells11203216` | CelVivo | NAFLD mapping proteome/lipidome |
 By vendor (30-day mtime):
 | Vendor | Most recent | 2026-08-08 / 2026-08-10 / 2026-08-12 / 2026-08-16 additions |
 | --- | --- | --- |
 | CelVivo | 2026-08-12 (Liang 2026 — ClinoStar rating 5 + ClinoReactor rating 5) | +Liang 2026 (P1-P10 长程成熟 + 单组织 3 轨道分通道灌流 + TGFβ 时间程序精确切换 — liver organoid fibrosis platform), +Miao 2025 v2 (ClinoStar co-differentiation), +Sharma 2026 (ClinoStar rating 3 adjacent), +Liu 2026 (ClinoStar rating 4 adjacent), +Quintard 2024 (CelVivo ClinoStar rating 3 — upstream workflow step: BVO day 0-15 needs rotating-wall suspension culture), +Guo 2026 (CelVivo ClinoStar rating 4 — clinical-translation IRB compliance for 三甲医院 客户) |
 | 3Brain | 2026-08-08 (Liu 2026 — HD-MEA rating 5) | +Liu 2026 (shape-conformal framework, next-gen HD-MEA), +Sharma 2026 (HD-MEA rating 4 adjacent), +Shin 2024 (Phase A frontmatter hygiene on existing note), **−3Brain reference removed from Quintard 2024 -v4 (per commit `4073abf4` — "精读 Quintard 2024 -v4 (转发语标题/落款加粗/删3Brain)" was the explicit SOP rule "硬门槛合规修正" cleanup; Quintard is vendor-adjacent CelVivo/Mimetas/Emulate rather than 3Brain territory)** |
 | Cellink | 2026-07-27 (Tasevska 2025) | +Liu 2026 (microlattice fabrication rating 5 adjacent), **+Quintard 2024 (microfluidic organ-on-chip adjacent, no direct Cellink rating — but the platform architecture is a candidate cross-sell with Cellink BIO X for vascularized scaffold fabrication)** |
 | Adjacent (no vendor) | 2026-08-08 (Sharma 2026 retinal vascularization) | +Sharma 2026 (retinal organoid application domain) |
 | (Process discipline) | 2026-08-10 (Phase A batch + first MOC) | +6 deep-reads received 6-field frontmatter; +first MOC `MOC-类器官与3D培养.md` created; +7 image alt descriptions on Wang 2024 — no new external evidence |
 | (Subfolder expansion, uncommitted) | 2026-08-13 (new `Review/` subfolder) | +1 untracked file `Review/zhou2023_computer_vision_microfluidics.md` (first review-type subfolder — review papers stream separately from original research) |
 | (Customer-facing template, uncommitted) | 2026-08-16 (new `templates/` subfolder + IRB application checklist v1.0) | +1 untracked file `templates/类器官IRB申请清单.md` 180 lines (Guo 2026 ethics deep-read → IRB checklist template; 7 mandatory points + 5 customer Q&A + China vs International flow + 10 attachments + 7 citations; Robin's first customer-facing template produced from a single deep-read; will route into CelVivo industrial-customers program once committed) |
 | (Commercial quote PDF, untracked) | 2026-08-17 (new `celvivo_commercial/` subfolder) | +1 untracked file `celvivo_commercial/1331651_20260630_131201.pdf` (6-30 quote PDF migrated into a new folder; companion to the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree) |
 The pipeline is **vendor-balanced** — CelVivo, 3Brain, Cellink each have a recent deep read, and the 2026-08-08 flywheel-sync adds **3 papers spanning all 3 primary vendors + the retinal organoid application domain** (Sharma), all 3 rated 4-5 on at least one vendor's product line. The 2026-08-10 cluster is **process discipline** (Phase A metadata batch + first MOC creation + Wang 2024 alt-description sample), not new external evidence — the 6 deep-reads already existed on `main`; the 3 commits only normalize their metadata and add a knowledge-graph index layer. The 2026-08-12 cluster adds **net-new external evidence**: Liang 2026 Sci Rep liver organoid fibrosis platform (4-commit LDR cycle on a single paper, CelVivo ClinoStar ⭐⭐⭐⭐ + ClinoReactor ⭐⭐⭐⭐); this is the **first paper on `main` whose `related:` field already names `[[MOC-类器官与3D培养]]` on the day of publication**, confirming the MOC pattern is in active use on real deep-reads (vs the prior 2026-08-10 "MOC `related:` lists future MOCs" framing which was only prospective). The **first entry in the new NocoDB table `Robin_Picked_Papers`** is Liu 2026 (created 2026-08-08 per Robin instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage). The **first MOC** `MOC-类器官与3D培养.md` is the start of a Map-of-Content layer Robin appears to be building (the MOC's own `related:` already names `[[MOC-3Brain-HD-MEA]]` as the next planned MOC). The 2026-08-13 cluster (no vault commits, 1 new untracked file) **adds a new `Review/` subfolder to the deep-read tree** — Robin appears to be expanding the folder taxonomy to separate review-type papers from original-research papers; whether this is a one-off subfolder or the start of a recurring folder pattern is a watchlist item for the next git-repo fetch. **The 2026-08-16 cluster (Quintard 2024 + Guo 2026) is the largest single-window vault delta since the 2026-07-28 / 2026-07-29 cluster** — 7 new vault commits spanning 2 new paper deep-reads, 2 new untracked working-tree directories, and 1 customer-facing sales-ammunition template derived from a single deep-read. The Quintard 2024 microfluidic / organ-on-chip platform (CelVivo ClinoStar upstream + Mimetas OrganoPlate direct competitor + Emulate Organ-Chip) extends Robin's vendor mapping into the organ-on-chip product lane that his portfolio doesn't currently cover; the Guo 2026 organoid ethics systematic review (7 mandatory points + 5 jurisdiction comparison) introduces the IRB / ethics domain to Robin's deep-read set and spawned `templates/类器官IRB申请清单.md` (180 lines, Robin's first customer-facing template) as the canonical "Robin 培训客户 IRB 申请" core material. The new `templates/` + `celvivo_commercial/` directories appear alongside the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree — Robin may be formalizing customer-facing deliverables (checklists / templates / sales scripts) as a separate vault subtree. The `Review/zhou2023_computer_vision_microfluidics.md` carry-forward untracked file is still-uncommitted at this fetch (now 4 days past the 2026-08-13 first observation); the watchlist trigger is if it remains uncommitted at the next fetch.
 ## Sales ammunition pipeline
 Robin maintains a working sales library that consumes LDR output and routes into the `/sources/sales-ammunition.md` page:
 - **Pricing + SKUs:** Demo kit `10005-6` lists at €300 (Global Distributor Price, with special discount); `10004-12` ClinoReactor 12-pack; `30003` ClinoStar; `SP5D-24W` low-adherence plate. Pricing source: `Exhibit 1_Celvivo Price Book 2026_Global_Distributior.xlsx` (RAGFlow KB full-text).
 - **8 ClinoReactor Protocols:** 003 (prepare) / 004 (media change) / 006 (gardening) / 009 (plate config) / 010 (ClinoReactor prepare) / 012 (rotation speed — core selling point) / 014 (alginate embed) / 015 (VitroGel embed).
 - **5 application notes by organ:** HepG2/C3A liver / FTC-133 thyroid / NCI-H69V SCLC / TNBC / ClinoStar vs Orbital Shaker.
 - **5 brand / whitepapers:** Brochure 2026 update_for print + _online version / Cancer White Paper 2026 / 2026.04.01.715868v1 (biorxiv 2026 preprint) / ijms-24-13506-v2.
 - **8 commercial docs:** Exhibit 1 Price Book / Exhibit 3 SuperUser certification / Huibai demo discount agreement / 惠百 PO 盖章版 / Celvivo Distribution Agreement 2026 Huibai Bio / 1331651_20260630_131201 (6-30 quote) / Packing Slip Ordre 726_1 / Packing Slip Ordre 726_2.
 Cross-link to the canonical synthesis: [`/sources/sales-ammunition.md`](/sources/sales-ammunition.md).
 **2026-08-16 addition — `templates/类器官IRB申请清单.md` v1.0** (180 lines, Robin 8-16 实战沉淀, **untracked**; derived from Guo 2026 Front Cell Dev Biol IRB / ethics systematic review — Wiki.js ID 1724, NocoDB Id 3298). The IRB application checklist is **Robin 第一份 customer-facing template produced from a single deep-read** and consists of: (a) **7 强制要点** [样本来源合法性 + 捐赠者知情同意 + 数据隐私与去标识化 + 共培养产物主体性评估 + 动物福利 3R + 跨境监管合规 + 长期保存与终止使用]; (b) **5 customer Q&A** [类器官研究是否要 IRB 申请 / 类器官共培养产品怎么申请 IRB / 类器官跨境研究怎么报 / 3R 原则怎么写 / 类器官 + 免疫细胞共培养 = CAR-T 体外培养, 算不算新生物体]; (c) **China vs International flow comparison table** [中国 2023 新规 vs 美国 Common Rule vs 欧盟 GDPR]; (d) **10 申请附件清单** [IRB 申请表 + 知情同意书 + 研究方案 + DMP + 样本采集机构 IRB 批件 + ...]; (e) **7 引用** [Guo 2026 + ISSCR 2021 + OHRP 2016 + GDPR + 中国 2023 + 中国 2019 + Cambridge 2020]. **Vendor relevance**: CelVivo ClinoStar ⭐⭐⭐⭐ (the 7 mandatory points directly apply to ClinoStar customer IRB submissions; **Robin 推广 ClinoStar 给三甲医院时, 可附带本框架作为增值**). Tracks as `/commitments.md` `guo-2026-organoid-irb-checklist-rollout` (Owner: me; fold IRB application checklist into CelVivo industrial-customers program + Robin customer-training core material; commit `templates/类器官IRB申请清单.md` and add a synthesis page at `/sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md`).
 ## Sales training cluster (working-tree additions)
 Per `/sources/git-repo.md` §"Notable entities", `06-Sales/Content/Training-Materials/` contains the following working-tree additions not yet on `main`:
 - `CelVivo_销售培训_PPT_v9_给销售看版.pptx` (3.9 MB, 06-26 14:13) — latest PPT
 - `CelVivo_Robin老师逐字稿_v6_深度版_20260626.md` (63 KB, 06-26 13:45) — latest verbatim script
 - `CelVivo_销售培训_讲义_v2_20260626.md` (13 KB, 06-26 12:14) — latest handout
 - `Robin稿生成通字稿` family (v3–v6) and `CelVivo赋能培训` family (v1–v9, depth-flavored edits)
 - `销售基础话术包` pair
 The version progression is `基础 → 5大管线 → 深度版 → 终稿修正 → 销量仅看` — the cluster is iterated in place, not committed. See [`/sources/vault-mtime-snapshot-2026-07-16.md`](/sources/vault-mtime-snapshot-2026-07-16.md) for the latest mtime census (CelVivo_销售培训_PPT_v9 = 2026-06-26 14:13).
 ## China distributor map (259 dealers across 7 regions — 2026-08-07 baseline)
 From [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) (Hermes整理, 2026-08-07; **replaces 2026-07-24 baseline of 261 dealers**):
 | Region | 8-07 count | 7-24 count | Δ | Share | Main city |
 | --- | ---: | ---: | ---: | ---: | --- |
 | 华北 | 72 | 74 | -2 | 27.8% | 北京 (54) |
 | 华东 | 68 | 68 | 0 | 26.3% | 上海 (53) |
 | 华南 | 62 | 62 | 0 | 23.9% | 广州 (44) |
 | 山东 | 25 | 25 | 0 | 9.7% | 济南 (22) |
 | 湖北 | 19 | 19 | 0 | 7.3% | 武汉 (12) |
 | 西北 | 6 | 6 | 0 | 2.3% | 西安 (6) |
 | 西南 | 7 | 7 | 0 | 2.7% | 重庆 (3) |
 | **TOTAL** | **259** | **261** | **-2** | 100% | — |
 Brand keyword map (top 20 by 全国 count): BI 19 / Thermo 19 / Bio-Rad 11 / 赛默飞 8 / 安捷伦 7 / 蔡司 6 / Cytiva 6 / 伯乐 6 / 徕卡 6 / 赛多利斯 5 / Eppendorf 5 / Leica 5 / Beckman 4 / Merck 4 / Waters 4 / Azure 3 / Bruker 3 / Oxford Nanopore 3 / Agilent 3 / Sartorius 3.
 **8-07 独有产品-代理映射 (from `_known_associations.md`):**
 | 产品线 | 关联代理 / 中间方 | 关联客户 / 商机 |
 |---|---|---|
 | CelVivo (ClinoStar) | **济南成全生物科技 (曹沛起)** — 华北 + 山东 跨区重复 | 董慧群 (CelVivo 技术同事) — 8-07 hook 4 候选 |
 | FemtoBiomed (CellShot / PROLIVA) | **9X Bio (汇佰生物)** — 中间方 (0 hit in 259 dealer 表) | TriArm Therapeutics (翁靖傑 上海 CGT/CAR-T, 128 万 Phase1 / 8-10 至 8-14 现场 demo) |
 | 3Brain (HD-MEA) | 0 家代理命中 | 11+ end-customer dossiers (需要补 direct agent or sell direct) |
 | Cellink (BIO X) | 0 家代理命中 | (待补) |
 **Data gap (regional filling rate):** 华东 营收 0/68 / 湖北 营收 0/19 / 华南 销售人数 0/62 — needs补 before next field visit. Documented at [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) §关键数据缺口.
 **4-vendor break-out is partially resolved:** the 2026-08-07 `_known_associations.md` index identifies CelVivo → 济南成全 + FemtoBiomed → 9X Bio; 3Brain / Cellink direct agents are still 0 (open-question `distributors-3brain-cellink-zero-coverage`).
 ## CRM — active distributor profiles
 From [`/sources/agents.md`](/sources/agents.md) (last sync 2026-07-28; 2026-08-07 `_known_associations.md` partial resolution):
 | 姓名 | 角色 | 代理商品牌 | 主推产品 | 首次记录 | 状态 | Vault 路径 |
 | --- | --- | --- | --- | --- | --- | --- |
 | 董慧群 | 代理商技术同事 | 待补 | CelVivo (ClinoStar / ClinoReactor) | 2026-07-28 | active | `02-Clients/Agents/董慧群.md` |
 This is the only profile currently in the agents bucket. Robin was told about 董慧群 via WeChat DM on 2026-07-28; her role is to help push CelVivo products at the technical / demo / selection stage. Most fields are 待补 (agency name, region, phone, WeChat, customers, opportunities) — this is the only active open question in `/open-questions.md` (see `agent-dong-huiqun-celvivo`).
 **2026-08-07 partial resolution (Hermes hook 4):** 4 个经销商管理 Hook 升级 (`02-Clients/Agents/_known_associations.md` commit `4b237a82`) identifies **济南成全生物科技有限公司 (曹沛起)** as the only CelVivo ClinoStar-listed agent in the 259-dealer China map (华北 + 山东 跨区重复登记). Whether 董慧群 is 济南成全的技术同事 or another dealer is still unverified — tracked as commitment `dong-huiqun-ji-nan-chengquan-link` in `/commitments.md`. The same hook 4 file maps FemtoBiomed CellShot → 9X Bio (汇佰生物) → TriArm Therapeutics (翁靖傑 上海 CGT/CAR-T, 128 万 Phase1 / 8-10 至 8-14 现场 demo), and 3Brain / Cellink / FemtoBiomed direct agents → 0 in the 259 baseline (open-question `distributors-3brain-cellink-zero-coverage`).
 **Privacy rule (Robin 7-28):** `/sources/agents.md` and `/sources/distributors-china-2026.md` contain only base identity (name / role / vendor / region); sensitive fields (phone / WeChat / email / end-customer list / opportunity value) live only in the private Obsidian vault. The 2026-08-07 `_known_associations.md` index adds the **product-line → agent → end-customer → opportunity** mapping chain — but does not break the privacy rule because sensitive fields remain in the private vault files.
 ## End-customer dossier set
 11+ dossiers under `03-Resources/End-Customers/` covering 3Brain HD-MEA accounts at: 神经所 (上海), 北京大学, 北京天坛医院, 浙大一附院, 中科院昆明动物所, 西南医科大学, 贵州医科大学, plus TCM accounts at 云南中医药大学 and 天津创新中药. Dossier content lives in the private vault — only the vault paths are surfaced to the wiki. Documented at [`/sources/git-repo.md`](/sources/git-repo.md) §Notable entities.
 ## CelVivo industrial-customers program (China commercial)
 A dedicated subfolder under `05-Documents/Products/Celvivo/Industrial-Customers/` holds:
 - `CelVivo_中国工业客户开发研究报告` (v1 + v2)
 - `客户管线定位_1页图`
 - `工业客户开发手册-v3`
 This is a self-contained CelVivo China commercial effort. The latest mtime census (2026-07-16 snapshot) shows `CelVivo_中国工业客户开发研究报告_20260626_v2.md` as the most-recent file (18 KB, 06-26 11:52). Documented at [`/sources/git-repo.md`](/sources/git-repo.md) §Notable entities.
 **2026-08-17 working-tree addition — `celvivo_commercial/1331651_20260630_131201.pdf`** (56 KB, 2026-06-30 quote PDF migrated into a new folder; **untracked**) — companion to the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree. The new folder name signals Robin may be consolidating "Celvivo commercial" documents into a separate vault subtree rather than continuing to nest them under `05-Documents/Products/Celvivo/Industrial-Customers/` (which is the prior convention). If the convention holds, future CelVivo commercial PDFs / quotes / pricing tables will land in `celvivo_commercial/` instead of `05-Documents/Products/Celvivo/Industrial-Customers/`; if it doesn't hold, it's a one-off folder for the 6-30 quote. Watchlist trigger: if a second PDF or commercial doc lands in `celvivo_commercial/` by the next git-repo fetch, the convention change is real; if it stays single-entry, it's a one-off.
 ## Work-rhythm snapshot (2026-07-16)
 From [`/sources/vault-mtime-snapshot-2026-07-16.md`](/sources/vault-mtime-snapshot-2026-07-16.md) (last full mtime census):
 ```
 2026-07-05  CelVivo 文献精读最后一次 (1 篇)
 2026-06-26  销售培训物料最后一次更新 (v9 PPT + 逐字稿)
 2026-06-18  memory/ 最后一次 daily report
 2026-06-09  vault commit 最后一次
 2026-06-06  CelVivo protocol 系列入库最后一次
 2026-06-04  weekly report 最后一次
 ```
 **Conclusion (snapshot date):** Past 3 weeks (post 2026-07-05) had 0 CelVivo activity. This is **real state**, not an OpenWiki gap. The snapshot recommends Robin write a `memory/2026-07-16-*.md` daily report to capture the gap. This also means the OpenWiki cron `vault-mtime-snapshot` connector is the canonical work-rhythm evidence — it complements the git-repo connector (commit history) and NocoDB (last-touched metadata).
 ## Cross-vendor route map
 Each research output eventually lands in one of the vendor synthesis themes:
 | Research artifact | Primary route | Secondary |
 | --- | --- | --- |
 | CelVivo deep reads + sales ammunition | [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) | CelVivo industrial-customers program → `/commitments.md` |
 | 3Brain deep reads + end-customer dossiers | [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) | 3Brain conference positioning → `/commitments.md` `3brain-coreplate-2026-conference-positioning` |
 | Cellink deep reads + BIO X customer evidence | [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md) | New Lumen X release → `/commitments.md` `cellink-volumetric-lumen-x-release` |
 | Femtobiomed deep reads + CellShot-TriArm demo plans | (theme gap — Femtobiomed has no synthesis theme yet) | `01-Active-Sales/` plans → `/commitments.md` |
 | Adjacent non-vendor (MSC / canine / PEMF / 综述) | `class-organoid-3d-bioprinting` theme row on [`/themes.md`](/themes.md) | — |
 | China regulatory (CDE / Order 818 / CGT) | `/commitments.md` items `china-cde-cell-gene-therapy-rules-2026` / `china-order-no-818-clinical-translation` / `china-cgt-2026-july-developments` | — |
 | Distributor / agent | [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) + [`/sources/agents.md`](/sources/agents.md) + `/open-questions.md` `agent-dong-huiqun-celvivo` | — |
 ## Personal-infra and adjacent work
 These are source-anchored but not vendor-anchored — they live here for traceability but do **not** earn a `/themes.md` row:
 - **ITX 24h host build (first observed 2026-07-31; still untracked)** — `03-Resources/ITX-24h-Host/ITX_24h_Host_v18_Config_2026-07-31.md`. Plan: mATX + i5-12400 + DDR4-2666 32G + 板载 Realtek 1Gb + Intel PRO/1000 GT 双网卡 NAS 隔离. Budget ¥2,985.82, 10/11 parts arrived. Status: paused awaiting last #8/#9 cable parts. Tracked as `/commitments.md` `itx-24h-host-build-2026-q3` (Owner: me).
 - **OpenWiki cheat sheet (2026-07-27)** — `OpenWiki速查手册_2026-07-27.md` (vault root, untracked). Companion to [`/sources/OpenWiki速查手册.md`](/sources/OpenWiki速查手册.md) (the wiki copy).
 - **4 vendor + 4 application + 4 agents SOP iterations** — the cluster of training materials under `06-Sales/Content/Training-Materials/` is iterated in place without commits; latest is `CelVivo_销售培训_PPT_v9` (06-26 14:13).
 ## Cross-cutting relationship
 - **Touched by [`/themes/03-ai-agents.md`](/themes/03-ai-agents.md)** — M3 agent synthesis step (02:00 cron) writes research evidence into the synthesis themes; literature-deep-read SOP is what produces the canonical deep-read pages; sales-ammunition query skill routes ClinoReactor-related questions.
 - **Touched by [`/themes/04-local-llm.md`](/themes/04-local-llm.md)** — RAGFlow KB (Celvivo / 3Brian / Cellink) is the deep retrieval surface behind every vendor deep read; SeaFile is the PDF + figure storage; NocoDB is the metadata catalog; Wiki.js is the public publishing target. The 2026-07-17 desktop service-down incident materially degrades the LDR pipeline.
 - **Output routes into [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) and [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md)** — most of the deep reads and vendor evidence in this theme ends up at the vendor synthesis themes.
 - **Outputs routed into `/commitments.md`** — China regulatory items + vendor-channel verification items + ITX host build + CellShot-TriArm demo plans.
 - **Outputs routed into `/open-questions.md`** — `agent-dong-huiqun-celvivo` is the only currently active entry; it is anchored to `02-Clients/Agents/董慧群.md` and is the kind of "ambiguous people/org relationship" gap the wiki brief calls out.
 ## Backlog for this theme
 - **Femtobiomed synthesis page** — `Femtobiomed CellShot / CellPick / TriArm` has a vault bucket and a `FemtoBiomed_electroporation` RAGFlow KB (123 docs) but no synthesis theme. Currently routes as adjacent cross-sell into `01` and `02`. Consider promoting to `themes/06-femtobiomed.md` if vendor-channel evidence accrues.
 - **Hodge / Lee / Parate synthesis** — 3 adjacent deep reads added 2026-07-28 are not yet synthesized to `/sources/`. Run LDR Step 8 (NocoDB PATCH + Wiki.js publish + OpenWiki commit) when ready.
 - **Work-rhythm snapshot connector** — currently a one-shot `find -mtime` shell command (see `/sources/vault-mtime-snapshot-2026-07-16.md` header). Promote to a weekly cron + auto-write to `/sources/vault-mtime-snapshot-weekly.md` so the work-rhythm signal is durable, not single-snapshot.
 - **End-customer dossier cross-agent page** — 11+ dossiers live in private vault; consider adding a redacted `[name, focus, vendor, region, vault-path]` table to `/sources/agents.md` parallel to the distributor profile pattern. Robin decision pending.
 - **CellShot-TriArm demo plan v3** — current demo plans are v1 (2026-07-21) and v2 (2026-07-22, 邮件用 + 老师版 two-commit split). No v3 yet; the v2 plan lives in vault commit history `1787702c` / `62877d1f` / `62d09c5f`. Promote to `/commitments.md` when v3 lands.
 - **MOC pattern extension (2026-08-10 onward)** — Robin created the first MOC
  (`04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md`, commit `6b717aef`,
  95 lines, 沙牛《AI 时代的 Obsidian 公开课》课时 1 pattern); the MOC's
  `related:` list already names the next planned MOC —
  `[[MOC-3Brain-HD-MEA]]` — plus
  `[[02-Clients/Agents/_known_associations]]` and
  `[[02-Active-Deals/CellShot-TriArm-Demo-计划-v2-老师版-2026-07-20]]`.
  Track on the next git-repo fetch whether the MOC pattern extends to
  MOC-3Brain-HD-MEA, MOC-Cellink-BIO-X, MOC-Femtobiomed-CellShot, etc.
  If ≥3 MOCs land, consider adding a `/themes.md` annex row on
  `vault-knowledge-architecture` and a `/sources/` page that maps the
  MOC graph (file → topics → cross-refs → flywheel cron hooks).
 - **Phase A frontmatter batch rollout (2026-08-10 onward)** — Phase A
  standardized 6 deep-read notes with the 6-field frontmatter
  (doi / journal / year / volume / pages / authors / pmid); ~1,196
  deep-read notes remain without the new fields. Track rollout
  cadence — if Robin completes the batch on a fixed cadence (e.g.
  daily/weekly cron), document the cadence here so future agents can
  answer "what is the frontmatter hygiene status of the vault?".
 ## What to read next
 | Question | Go to |
 | --- | --- |
 | What is the canonical LDR master template? | [`/sources/ldr-report-template.md`](/sources/ldr-report-template.md) |
 | What did the 7-27 SOP-vs-implementation pass reveal? | [`/sources/2026-07-27-4-27-sop-vs-implementation.md`](/sources/2026-07-27-4-27-sop-vs-implementation.md) |
 | What is the current Obsidian vault manifest? | [`/sources/git-repo.md`](/sources/git-repo.md) |
 | What is the 30-day literature deep-read digest? | [`/sources/literature.md`](/sources/literature.md) |
 | What is in the CelVivo sales ammunition kit? | [`/sources/sales-ammunition.md`](/sources/sales-ammunition.md) |
 | What is the China 261-dealer map? | [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) |
 | Who is Robin actively working with? | [`/sources/agents.md`](/sources/agents.md) |
 | What is the work-rhythm cadence? | [`/sources/vault-mtime-snapshot-2026-07-16.md`](/sources/vault-mtime-snapshot-2026-07-16.md) |
 | What does the CelVivo 2026 whitepaper say? | [`/sources/literature-celvivo-brain-whitepaper-2026.md`](/sources/literature-celvivo-brain-whitepaper-2026.md) |
 | What does the Bosnjakovic 2025 PAH paper say? | [`/sources/literature-cel-bosnjakovic-2025-pah-deepread.md`](/sources/literature-cel-bosnjakovic-2025-pah-deepread.md) |
 | What is the Raji 2026 hMOs + 3Brain story? | [`/sources/literature-raji-2026-deepread.md`](/sources/literature-raji-2026-deepread.md) |
 | What is the Tasevska 2025 BIO X SSE story? | [`/sources/literature-tasevska-2025-deepread.md`](/sources/literature-tasevska-2025-deepread.md) |
 | How does the agent stack consume this output? | [`/themes/03-ai-agents.md`](/themes/03-ai-agents.md) |
 | How does the local-LLM fleet host this evidence? | [`/themes/04-local-llm.md`](/themes/04-local-llm.md) |
 | Where does CelVivo + 3Brain output land? | [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) |
 | Where does Cellink output land? | [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md) |
 | What does Quintard 2024 say about vascularized organoid chips? | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
 | What does Guo 2026 say about organoid IRB ethics? | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
 | What's the IRB application checklist for organoid research? | `templates/类器官IRB申请清单.md` v1.0 (vault path; untracked) ||th; deep-read synthesis not yet split out to `/sources/`) |
 | What's the IRB application checklist for organoid research? | `templates/类器官IRB申请清单.md` v1.0 (vault path; untracked) ||t path; untracked) ||
@@ -0,0 +1,7 @@
 # Files
 - [Theme 1 · Organoid culture and equipment (CelVivo / 3Brain)](01-organoid-equipment.md) - Synthesis page for Robin's organoid culture and equipment theme — CelVivo ClinoStar/ClinoReactor for 3D suspension culture and 3Brain HD-MEA for neural/cardiac electrophysiology readout.
 - [Theme 2 · 3D bioprinting (Cellink / BIONOVA)](02-bioprinting.md) - Synthesis page for Robin's 3D bioprinting theme — Cellink BIO X / BIONOVA X / Lumen X extrusion and DLP printing hardware for tissue engineering, drug tablets, and scaffold fabrication.
 - [Theme 3 · AI Agent tools (Hermes / Codex / MiniMax code)](03-ai-agents.md) - Synthesis page for Robin's daily-driver AI agent stack — Hermes Agent on WSL, MiniMax code on the desktop, Codex CLI fallback, OpenWiki as cross-agent memory substrate, and supporting toolchain (RustDesk, Gitea, Wiki.js, RAGFlow).
 - [Theme 4 · Local LLM deployment (Ollama / bge-reranker / RAGFlow)](04-local-llm.md) - Synthesis page for Robin's local-LLM fleet — Ollama serve + qwen2.5vl:7b vision model + BAAI/bge-m3 embeddings (Ollama + LM Studio) + bge-reranker rerank + RAGFlow KB retrieval + adjacent NAS subsystems (NocoDB / SeaFile / Wiki.js / Feishu mail).
 - [Theme 5 · Robin's personal research (vendor deep reads + sales ammunition + CRM)](05-robin-research.md) - Synthesis page for Robin's personal research portfolio — Obsidian vault + literature deep-read pipeline + sales ammunition + China distributor map + active CRM profiles + work-rhythm snapshots. Output routes into vendor themes 01 (organoid-equipment) and 02 (bioprinting).
Author	SHA1	Message	Date
OpenWiki Bot	a9568d86d5	chore: daily update 2026-08-23	2026-08-23 02:33:39 +08:00
OpenWiki Bot	8f8f767886	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-23)	2026-08-23 02:30:02 +08:00
OpenWiki Bot	43d45483b5	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-22)	2026-08-22 02:30:02 +08:00
OpenWiki Bot	d8e2277205	chore: daily update 2026-08-22	2026-08-22 02:17:39 +08:00
OpenWiki Bot	f6c2576c2f	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-21)	2026-08-21 02:30:02 +08:00
OpenWiki Bot	b6dc337830	chore: daily update 2026-08-21	2026-08-21 02:27:31 +08:00
OpenWiki Bot	bd30339182	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-20)	2026-08-20 02:30:02 +08:00
OpenWiki Bot	a44f284dc9	chore: daily update 2026-08-20	2026-08-20 02:15:52 +08:00
OpenWiki Bot	dcb53a2873	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-19)	2026-08-19 02:30:02 +08:00
OpenWiki Bot	7e904ecd7a	chore: daily update 2026-08-19	2026-08-19 02:22:15 +08:00
OpenWiki Bot	1fc73aeeff	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-18)	2026-08-18 02:30:02 +08:00
OpenWiki Bot	812779732b	chore: daily update 2026-08-18	2026-08-18 02:23:43 +08:00
OpenWiki Bot	be49285533	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-17)	2026-08-17 02:30:02 +08:00
OpenWiki Bot	5c70881b28	chore: daily update 2026-08-17	2026-08-17 02:05:16 +08:00
OpenWiki Bot	997b648cbd	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-16)	2026-08-16 02:30:03 +08:00
OpenWiki Bot	151d22bbc6	chore: daily update 2026-08-16	2026-08-16 02:17:19 +08:00
OpenWiki Bot	2507925e27	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-15)	2026-08-15 02:31:10 +08:00
OpenWiki Bot	173b58c5dd	chore: daily update 2026-08-15	2026-08-15 02:00:57 +08:00
OpenWiki Bot	62587177b1	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-14)	2026-08-14 02:30:03 +08:00
OpenWiki Bot	021e929b92	chore: daily update 2026-08-14	2026-08-14 02:18:06 +08:00
OpenWiki Bot	1737454ad1	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-13)	2026-08-13 02:30:03 +08:00
OpenWiki Bot	8ddc6d9559	chore: daily update 2026-08-13	2026-08-13 02:19:02 +08:00
OpenWiki Bot	c57ead4bf1	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-12)	2026-08-12 02:30:02 +08:00
OpenWiki Bot	431ee6a413	chore: daily update 2026-08-12	2026-08-12 02:00:45 +08:00
Robin	b64ae41f3f	lit: PMID 41536916 Bioactive Materials AIVOs 综述 (Wiki.js 1711)	2026-08-11 15:18:38 +08:00
Robin	523ee7f540	lit: PMID 41686639 Cell Reports TNBC DEO + ROCK (Wiki.js 1710)	2026-08-11 13:40:38 +08:00
Robin	9be4f55435	lit: PMID 41909700 Front Immunol 2026 类器官-小胶质细胞综述 (Wiki.js 1709)	2026-08-11 13:28:52 +08:00
Robin	cc69eceb51	lit: PMID 42041571 v4 - 按 literature-deep-read-research 9 项强制格式	2026-08-11 12:35:37 +08:00
Robin	b4bc8d9081	lit: PMID 42041571 修正 - 真实PDF + 10张真图链接	2026-08-11 12:29:29 +08:00
Robin	12480ab166	lit: 修正 wiki_url 到真实内网地址	2026-08-11 12:14:12 +08:00
Robin	cdc59c5962	lit: PMID 42041571 OVB-organoids vs cerebral organoids Cells 2026	2026-08-11 12:07:23 +08:00
OpenWiki Bot	2bcde39546	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-11)	2026-08-11 02:30:02 +08:00
OpenWiki Bot	7556e31a61	chore: daily update 2026-08-11	2026-08-11 02:11:51 +08:00
OpenWiki Bot	2bc03f3ddb	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-10)	2026-08-10 02:30:02 +08:00
Robin	dde053a6b0	auto: 2026-08-09 Wang 2024 Theranostics OrgOC 综述精读入口	2026-08-09 12:42:45 +08:00
OpenWiki Bot	3267338ba9	chore: daily update 2026-08-09	2026-08-09 02:33:45 +08:00
OpenWiki Bot	06f60e166b	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-09)	2026-08-09 02:30:02 +08:00
Robin	c94940c7d2	feat: add Microbioreactor 2026 v4 (PMID 42516424, ID 1696)	2026-08-08 15:58:09 +08:00
Robin	7f65024ac4	feat: add Microbioreactor 2026 v3 (PMID 42516424)	2026-08-08 15:52:55 +08:00
Robin	ea4f14aeeb	feat: add Microbioreactor 2026 v2 (PMID 42516424)	2026-08-08 15:48:27 +08:00
Robin	a193e46b3f	feat: add Microbioreactor 2026 (PMID 42516424) deep-read entry	2026-08-08 15:43:55 +08:00
Robin	bf90a919f4	fix: liu 2026 wiki link to main path	2026-08-08 10:49:09 +08:00
Robin	cf1dbe0c37	fix: liu 2026 final link	2026-08-08 10:34:25 +08:00
Robin	26efd2f693	fix: liu 2026 v5 link	2026-08-08 10:29:37 +08:00
Robin	e18993a637	fix: liu 2026 v4 link	2026-08-08 10:24:25 +08:00
Robin	b206bd911c	fix: liu 2026 v3 link	2026-08-08 10:22:12 +08:00
Robin	c26dbdf071	fix: liu 2026 wiki link to v2	2026-08-08 10:18:24 +08:00
Robin	703c3d4c99	literature: liu 2026 NBME shape-conformal organoid	2026-08-08 09:58:59 +08:00
Robin	1b78735e88	literature: miao 2025 cell v2	2026-08-08 09:15:32 +08:00
OpenWiki Bot	5adc4069aa	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-08)	2026-08-08 02:30:04 +08:00
Robin	037c5f3756	lit: add Sharma K 2026 Cell Stem Cell vRO retinal organoid (PMID 41529691)	2026-08-08 02:01:28 +08:00
OpenWiki v0.3.1	9e80977d4a	feat(openwiki): complete data flywheel activation (2026-08-07)	2026-08-07 20:36:36 +08:00
OpenWiki Bot	45af5a460d	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-07)	2026-08-07 19:16:11 +08:00
OpenWiki Bot	bcd4a4fdec	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-07)	2026-08-07 19:11:21 +08:00
OpenWiki v0.3.1	0bbef0f82b	feat(openwiki v0.3.1 --update): generate themes 4-5 + index.md + themes/ + sources/ index (2026-08-07)	2026-08-07 18:45:54 +08:00
OpenWiki v0.3.1	285c53b80a	feat(openwiki v0.3.1): add YAML frontmatter + install-id markers from initial init run (2026-08-07)	2026-08-07 18:35:38 +08:00
Robin	3102e968c4	feat(sources): 全国 261 家经销商地图 (2026-07-24, 不含敏感信息) - 新建 sources/distributors-china-2026.md - 含 7 地区索引 + 20 主流品牌 x 地区矩阵 - 按 sources/agents.md 隐私规则: 不含电话/微信/邮箱/联系人 - 数据源: Obsidian vault 02-Clients/Agents/*.md (2026-08-07 整理) - 与 agents.md 互补: agents='在跟' (1家), distributors='全景' (261家)	2026-08-07 11:44:04 +08:00
Robin	2e2bf120f2	test	2026-08-05 17:03:40 +08:00
Robin	ffbd5ab72f	v2: add GUI config iron rule (SSH toml overwritten), notebook install notes, Win11 user=20864	2026-08-05 09:58:05 +08:00
Robin	71d077d976	add RustDesk self-hosted setup notes 2026-08-05	2026-08-05 08:51:45 +08:00
Robin	cc25a26a03	literature: Yuan 2026 assembloids (ITX 端 hermes test)	2026-08-04 11:03:24 +08:00
OpenWiki Bot	aaafc2a58b	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-04)	2026-08-04 02:30:07 +08:00
OpenWiki Bot	196651f348	chore: daily update 2026-08-04	2026-08-04 02:20:19 +08:00
OpenWiki Bot	d2faf8fed5	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-03)	2026-08-03 02:30:14 +08:00
OpenWiki Bot	427f7be65a	chore: daily update 2026-08-03	2026-08-03 02:24:34 +08:00
OpenWiki Bot	7d8d754b4d	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-02)	2026-08-02 02:30:14 +08:00
OpenWiki Bot	32a43c9836	chore: daily update 2026-08-02	2026-08-02 02:22:26 +08:00
OpenWiki Bot	a01002d0f1	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-01)	2026-08-01 02:30:08 +08:00
OpenWiki Bot	dc9ce48fca	chore: daily update 2026-08-01	2026-08-01 02:13:52 +08:00
OpenWiki Bot	7d9ea64eb2	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-07-31)	2026-07-31 02:30:13 +08:00
OpenWiki Bot	79ef9939c7	chore: daily update 2026-07-31	2026-07-31 02:21:11 +08:00
OpenWiki Bot	5fbc0077b3	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-07-30)	2026-07-30 02:30:07 +08:00
OpenWiki Bot	e7d4f64e85	chore: daily update 2026-07-30	2026-07-30 02:13:32 +08:00
Hermes	61b7c0858b	feat(openwiki): append literature.md - Organoids disease modeling treatment 2026 review (PMID 41545895)	2026-07-29 19:52:21 +08:00
OpenWiki Bot	d5fce74d61	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-07-29)	2026-07-29 02:30:44 +08:00
OpenWiki Bot	61cd78a06a	chore: daily update 2026-07-29	2026-07-29 02:12:55 +08:00