chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-22)

chore: daily update 2026-08-22
chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-21)
2026-08-22 02:30:02 +08:00 · 2026-08-22 02:17:39 +08:00 · 2026-08-21 02:30:02 +08:00 · 2026-08-21 02:27:31 +08:00 · 2026-08-20 02:30:02 +08:00 · 2026-08-20 02:15:52 +08:00
32 changed files with 1556 additions and 168 deletions
@@ -1,5 +1,5 @@
 {
-  "updatedAt": "2026-08-10T18:09:51.993Z",
+  "updatedAt": "2026-08-21T18:16:08.658Z",
  "command": "update",
  "model": "MiniMax-M3",
  "status": "complete",
@@ -1,7 +1,8 @@
 ---
 type: "Reference"
 title: "OpenWiki 现状 + 操作手册 (2026-07-27)"
-openwiki_generated: true
+description: "Activation status + operations manual for Robin's local OpenWiki knowledge base as of 2026-07-27. Documents 4 active connectors (HN + git-repo + Tavily + RAGFlow) and the per-source sync scripts (HN top+best feeds, Tavily web-search with TAVILY_API_KEY, git-repo Obsidian vault at /home/ldw/workspace, RAGFlow full-text retrieval at 10.10.10.254:9980). Captures the on-disk Gitea commit + push pattern."
 tags: [openwiki, operations, manual, activation, 2026-07-27]
 ---
 # OpenWiki 现状 + 操作手册 (2026-07-27)
@@ -2,7 +2,7 @@
 type: "Reference"
 title: "Commitments"
 description: "Active work tasks, follow-ups, approvals, and scheduled items extracted from sources (web-search, git-repo, literature flywheel-sync, etc.). Personal errands live in /personal-logistics.md instead."
-tags: [commitments, work, follow-ups, distributors-2026-08-07-refresh, dong-huiqun-ji-nan-chengquan-link]
+tags: [commitments, work, follow-ups, distributors-2026-08-07-refresh, dong-huiqun-ji-nan-chengquan-link, liang-2026-celvivo-clinostar-positioning, guo-2026-organoid-irb-checklist-rollout]
 ---
 # Commitments
@@ -88,6 +88,13 @@ Concrete work tasks, follow-ups, approvals, and scheduled items extracted from G
 - Status: open
 - Notes: **Strongest CelVivo ClinoStar product relevance rating (5) in any of the 3 new flywheel-sync papers** — the vHLPO single 3D EB co-induction (mesoderm+endoderm) protocol depends on 3D EB self-organization in low-shear rotating culture, which is exactly what ClinoStar provides. vHLPO 7% ECs vs traditional HLPO 0% is a clinically-meaningful differentiator that no competing 2D / static culture can match. Sales ammunition: "your lung organoid model is missing 100% of vasculature — ClinoStar co-differentiation gives you 7% ECs vs 0%". Cross-vendor co-marketing: CelVivo ClinoStar (culture) + Cellink BIO X (decellularized lung scaffold) + 3Brain HD-MEA (functional readout on the neural mesenchyme). Robin should fold this into the CelVivo industrial-customers program (existing `CelVivo_中国工业客户开发研究报告` v1 + v2 in vault) and pitch to pediatric-hospital pharma R&D accounts (FOXF1 ACDMPV rare disease).
 ### liang-2026-celvivo-clinostar-positioning: fold Liang 2026 长程成熟 + 体外纤维化模型 story into CelVivo ClinoStar / ClinoReactor sales narrative
 - Owner: me
 - Source: git-repo-1 2026-08-12 (vault commit cluster `e542c977` → `8699a154` → `aacba7aa` → `297f106d`) — Liang Y, Ye Y, Xie H, Lui VCH, Chen Y, Tam PKH. (2026) *Scientific Reports* DOI 10.1038/s41598-026-42990-2, PMID 41857098; Wiki.js Id 1716, NocoDB Id 770; SeaFile PDF https://fb.biokingdom.top/f/9d53cfaaa88a45b49b72/?dl=1 + 7 真图 (Fig1-7); vault path `04-Literature/Deep-Reads/Liver/2026-08-12_Liang_2026_SciRep_liver_organoid_fibrosis_platform.md` (170 lines; 4-commit LDR cycle)
 - Due: unscheduled
 - Status: open
 - Notes: **Parallel CelVivo ClinoStar rating 4 + ClinoReactor rating 4 to the existing `miao-2025-celvivo-clinostar-positioning`** but for **liver organoid (long-term maturation + fibrosis modeling)** rather than lung organoid (vascularization). Single tissue 3-轨道 (Hep-Orgs + Cho-Orgs + HSC) → DAPT (Notch 抑制) + Dexamethasone for **P1-P10 长程稳定成熟** (single DAPT only sustains P5; DAPT+Dex 协同才实现 P10) → TGFβ 5-7 day activation of qHSC → aHSC (Acta2/Col1a1 上调) → aHSC 共培养诱导 Hep-Orgs **EMT (Snail/Twist/Vimentin ↑; ALB/CK8 ↓; Lgr5/EpCAM ↓; Ki67 ↓)** = **体外肝纤维化模型**. Sales ammunition: "你的肝类器官只能短期培养? DAPT+Dex P1-P10 稳定成熟 + 单组织 3 轨道 + 14 天纤维化模型 — ClinoStar + ClinoReactor 一站搞定"; paired with "你的抗纤维化药筛需要 14+ 天 3D 多细胞模型 — ClinoReactor 6 通道一次测 6 药". Cross-vendor co-marketing: **CelVivo ClinoStar (P1-P10 旋转扩增) + CelVivo ClinoReactor (3 轨道分通道灌流 + TGFβ 时间程序精确切换) + 3Brain HD-MEA (肝-神经互作延伸, 胆碱能投射场景)**. Customer entry: (a) 药企临床前 — 抗纤维化药筛 14+ 天 3D 多细胞模型 (traditional 2D 或单细胞模型失真); (b) 临床肝活检中心 — 1-2 mg 组织 → 3 轨道 → 3 周内药敏测试 (患者来源 anti-fibrosis drug sensitivity); (c) 学术 PI — 2D 静态分化效率低 → 3D 旋转培养效率提升 2-3 倍. Robin should fold this into the CelVivo industrial-customers program (existing `CelVivo_中国工业客户开发研究报告` v1 + v2 in vault) alongside the Miao 2025 vHLPO entry — these two papers together give a liver + lung CelVivo ClinoStar sales narrative with no 3D-bioprinting vendor dependency. The paper's `related:` field already names `[[MOC-类器官与3D培养]]` (the 2026-08-10 first MOC) — confirms the MOC pattern is in active use on real deep-reads on the day of publication.
 ### robin-picked-papers-nocodb-table: capture the structural change — new NocoDB table for Robin-handpicked papers
 - Owner: me
 - Source: literature flywheel-sync 2026-08-08 — Liu 2026 is the **first entry** in the new NocoDB table `Robin_Picked_Papers` (table_id `mbjo0wb56qv1qly`), created 2026-08-08 per Robin instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage. The table is separate from the existing `Organoid_Literature` table.
@@ -109,6 +116,13 @@ Concrete work tasks, follow-ups, approvals, and scheduled items extracted from G
 - Status: open
 - Notes: 8-07 baseline differs from 7-24 baseline in: (a) total 261 → 259 (华北 74 → 72); (b) 济南成全生物科技有限公司 (曹沛起) cross-region registration (华北 + 山东); (c) new `_known_associations.md` index maps CelVivo → 济南成全 / FemtoBiomed → 9X Bio → TriArm / 3Brain + Cellink → 0. Cross-reference: [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) has been updated to the 8-07 baseline + new associations table; [`/sources/agents.md`](/sources/agents.md) still needs the 董慧群 → 济南成全 link; [`/commitments.md`](/commitments.md) has follow-up for 成都百乐 vs 成都立德赛 decision (open-question `chengdu-baile-vs-lidesai-for-ou-xianhong`). End-customer coverage for 3Brain / Cellink / FemtoBiomed still 0 in the 259 baseline — see open-question `distributors-3brain-cellink-zero-coverage`.
 ### guo-2026-organoid-irb-checklist-rollout: commit IRB application checklist template + add Guo 2026 deep-read synthesis page + fold into CelVivo industrial-customers program
 - Owner: me
 - Source: git-repo-1 2026-08-17 — vault commit cluster `2e6f5989` → `00f824f2` → `a4fa5a32` (Guo Z & Zhang N 2026 Front Cell Dev Biol organoid IRB / ethics systematic review, Wiki.js ID 1724, NocoDB Id 3298, DOI 10.3389/fcell.2026.1721946) + new untracked `templates/类器官IRB申请清单.md` v1.0 (180 lines, Robin 8-16 实战沉淀, derived from the Guo 2026 paper)
 - Due: unscheduled
 - Status: open
 - Notes: **First customer-facing template produced from a single deep-read** in Robin's vault — the IRB application checklist is the canonical "Robin 培训客户 IRB 申请" core material for class A tertiary hospitals running organoid IRB submissions. The 7 mandatory points + 5 customer Q&A + China vs International flow table + 10 attachments + 7 citations map directly to the CelVivo ClinoStar clinical-translation sales narrative (Guo 2026 lists CelVivo ClinoStar ⭐⭐⭐⭐ for IRB compliance ammunition). **Three follow-ups needed**: (a) **commit** `templates/类器官IRB申请清单.md` to `main` (currently untracked); (b) add a wiki-side deep-read synthesis page at `/sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md` mirroring the pattern at `/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`; (c) fold the IRB checklist into the existing `05-Documents/Products/Celvivo/Industrial-Customers/` CelVivo commercial docs subtree (or, if the `templates/` folder convention holds, fold it into the new `templates/` vault subtree instead — see Robin decision). Companion commitment to fold into Chinese customer IRB conversations: the checklist covers China《人类遗传资源管理条例》+ 《涉及人的生命科学和医学研究伦理审查办法》2023 — directly applicable to the next Class A tertiary hospital Robin visits for CelVivo or 3Brain training.
 <!--
 Structure for new entries:
@@ -5,14 +5,15 @@ okf_version: "0.1"
 # Files
 - [Commitments](commitments.md) - Active work tasks, follow-ups, approvals, and scheduled items extracted from sources (web-search, git-repo, literature flywheel-sync, etc.). Personal errands live in /personal-logistics.md instead.
- [2026-07-16 工具链打通战报](memory-2026-07-16-tools-final.md)
+- [2026-07-16 工具链打通战报](memory-2026-07-16-tools-final.md) - After-action report on Robin's 2026-07-16 end-to-end toolchain integration: OpenWiki + Gitea + NocoDB + RAGFlow + Wiki.js + MiniMax code all wired together and working in production. Snapshot of the pre-flywheel-sync state — pre-dates the 2026-07-26 HN + Tavily launches and the 2026-07-29 Tavily cluster / 2026-08-08 literature flywheel-sync milestones.
 - [Open Questions](open-questions.md) - Active, Answered, and Stale unresolved questions about Robin's memory, recurring routines, people, projects, and wiki quality. Source-document TODOs and product questions live on their source pages instead.
 - [Personal Logistics](personal-logistics.md) - Personal errands, appointments, pickups, travel, household/life-admin deadlines, and other non-work logistics. Work commitments live in /commitments.md.
 - [Robin's Local Knowledge Base](quickstart.md) - OpenWiki entrypoint and orientation — Robin's personal knowledge base with 5 synthesis themes (organoid equipment, bioprinting, AI agents, local LLM, personal research), navigation map, current connector status, and backlog.
- [OpenWiki 现状 + 操作手册 (2026-07-27)](README-ACTIVATION.md)
+- [OpenWiki 现状 + 操作手册 (2026-07-27)](README-ACTIVATION.md) - Activation status + operations manual for Robin's local OpenWiki knowledge base as of 2026-07-27. Documents 4 active connectors (HN + git-repo + Tavily + RAGFlow) and the per-source sync scripts (HN top+best feeds, Tavily web-search with TAVILY_API_KEY, git-repo Obsidian vault at /home/ldw/workspace, RAGFlow full-text retrieval at 10.10.10.254:9980). Captures the on-disk Gitea commit + push pattern.
 - [Themes](themes.md) - Recurring topics, signals, and trends observed across Robin's sources. Index of theme rows with confidence labels and source citations; details live on the linked source and synthesis pages.
 # Directories
 - [large_tool_results](large_tool_results/)
 - [sources](sources/)
 - [themes](themes/)
@@ -1,7 +1,8 @@
 ---
 type: "Reference"
 title: "2026-07-16 工具链打通战报"
-openwiki_generated: true
+description: "After-action report on Robin's 2026-07-16 end-to-end toolchain integration: OpenWiki + Gitea + NocoDB + RAGFlow + Wiki.js + MiniMax code all wired together and working in production. Snapshot of the pre-flywheel-sync state — pre-dates the 2026-07-26 HN + Tavily launches and the 2026-07-29 Tavily cluster / 2026-08-08 literature flywheel-sync milestones."
 tags: [toolchain-integration, openwiki, gitea, nocodb, ragflow, wikijs, milimax-code, 2026-07-16]
 ---
 # 2026-07-16 工具链打通战报
@@ -1,7 +1,8 @@
 ---
 type: "Reference"
 title: "4-27 SOP 实战 vs 实现差异 (2026-07-27 Tasevska 2025 重做教训)"
-openwiki_generated: true
+description: "Lessons-learned capture from Robin's 2026-07-27 Tasevska 2025 EJPS deep-read redo — 9-step comparison table of 4-27 SOP范本 vs 7-27 凭印象实操 (Tasevska + Raji 2 篇) vs 4-27 SOP 走通 (Tasevska 重做); detailed PyMuPDF 嵌入图过滤 rules, Ollama 视觉 fallback chain, NocoDB v1 vs v2 protocol, and the 9-step mandatory format. Applies to every literature-deep-read invocation. Companion to `/sources/ldr-report-template.md`."
 tags: [literature-deep-read, sop-vs-implementation, lessons-learned, pymupdf, ollama, nocodb, 2026-08-13]
 ---
 # 4-27 SOP 实战 vs 实现差异 (2026-07-27 Tasevska 2025 重做教训)
@@ -1,7 +1,8 @@
 ---
 type: "Reference"
 title: "OpenWiki 速查手册 (Robin 一次聊清, 直接拿来用)"
-openwiki_generated: true
+description: "Compact OpenWiki cheat-sheet that condenses the 2026-07-27 6-conversation walkthrough into a single ready-to-share document. Designed for one-shot delivery to any agent / colleague / customer / manager who asks 'what is OpenWiki?' — covers the core concept, structure, sync model, and 4 active connectors in one page."
 tags: [openwiki, cheat-sheet, reference, onboarding, 2026-07-27]
 ---
 # OpenWiki 速查手册 (Robin 一次聊清, 直接拿来用)
@@ -2,7 +2,8 @@
 type: "Reference"
 title: "Sources"
 description: "Per-connector evidence indexes and ingestion coverage for the local knowledge wiki; durable synthesis lives on canonical pages."
-tags: [sources, connectors, evidence, ingestion]
+tags: [sources, connectors, evidence, ingestion, 2026-08-21]
 timestamp: 2026-08-21T18:35:00Z
 ---
 # Sources
@@ -13,9 +14,9 @@ Per-connector evidence indexes. Each connector gets its own page (for example `g
 | Connector | Page | Status |
 | --- | --- | --- |
-| Hacker News (`hackernews-1`, LLM-agent topics) | [/sources/hackernews.md](/sources/hackernews.md) | active |
+| Hacker News (`hackernews-1`, LLM-agent topics) | [/sources/hackernews.md](/sources/hackernews.md) | active (last 2026-08-21 18:00 UTC — tenth pull since 2026-08-07 with an empty / noise-only Algolia lane on vendor queries, all six Algolia queries (`organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents`) returning fully-zero hits — a stricter all-zero Algolia lane than the 2026-08-20 noise-only lane, with no application-domain thematic hits; the strongest named-stack-adjacent item is `49386163` "DeepSeek-v4-flash-vision-exp" 379 pts top+best (DeepSeek vision capability extension — DeepSeek V4 Flash is the canonical DeepSeek-M3 comparison benchmark cited on the `MiniMax-m3` row via benchlm.ai 2026-08-01, V4 vision is a V4-Flash capability milestone that expands into the same multimodal territory MiniMax-M3 occupies per the MyClaw.ai 2026-07-29 confirmation), with three secondary adjacents flagged for traceability: `49390739` Show HN Proliferate 11 pts (self-hostable open-source "Codex for any coding agent" — **Codex CLI is on Robin's named stack** but Proliferate is not, so adjacent-not-promoted per scope), `49378957` "The August 17 outage" 617 pts best / 722 cmts (GitHub blog post-mortem on the August 17 incident affecting Actions + Packages + Pages + Codespaces + API + webhooks; off-scope per scope but the highest-engagement infrastructure post-mortem of the pull), `49390463` "Building an (almost) fully self-hosted, sandboxed, agentic software factory" 16 pts top (4th entry in the 5-day self-hosted-agentic-substrate cluster after DeepSeek Harness 2026-08-13 + machine0 2026-08-18 + OneCLI 2026-08-19; cluster is now a recurring-signal watchlist candidate)) |
-| Git repo (`git-repo-1`, Obsidian vault + OpenWiki wiki) | [/sources/git-repo.md](/sources/git-repo.md) | active (last 2026-08-08 18:11 UTC) |
+| Git repo (`git-repo-1`, Obsidian vault + OpenWiki wiki) | [/sources/git-repo.md](/sources/git-repo.md) | active (last 2026-08-21 18:09 UTC — 0 new vault commits since 2026-08-20T18:09Z fetch (vault silent for the 5th consecutive fetch, **5 calendar days stale** since the 2026-08-16 Quintard + Guo cluster); 2 new automated wiki commits since 2026-08-20T18:09Z fetch (`b6dc337` daily update 2026-08-21 + `f6c2576` sources-sync 2026-08-21, the seventh consecutive sources-sync re-applying the 2026-08-15 count-data wipe pattern)) |
-| Web Search (`web-search-1`, Tavily) | [/sources/web-search.md](/sources/web-search.md) | active (latest pull 2026-08-03; 2026-08-08 and 2026-08-10 update attempts skipped — connector not enabled, `TAVILY_API_KEY` missing) |
+| Web Search (`web-search-1`, Tavily) | [/sources/web-search.md](/sources/web-search.md) | active (latest pull 2026-08-03; 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, 2026-08-17, 2026-08-18, 2026-08-19, and 2026-08-20 update attempts skipped — connector not enabled, `TAVILY_API_KEY` missing) |
 Additional connectors appear here automatically once they are authenticated and ingested at least once.
@@ -27,9 +28,9 @@ Additional connectors appear here automatically once they are authenticated and
 | Slack | not configured | `openwiki auth slack` | Needs `search:read` for definitive self-message search; otherwise falls back to recent conversations. |
 | Notion | not configured | Notion MCP credentials | Discovery via `openwiki_list_mcp_tools`; do not guess tool names. |
 | X / Twitter | not configured | `OPENWIKI_X_ACCESS_TOKEN` via `openwiki auth x` | Streams: `home_timeline`, `user_posts`, `mentions`, `bookmarks`, `list_posts`. |
-| Web Search | **active** (`web-search-1`) | `TAVILY_API_KEY` (currently empty) | Tavily via LangChain; reads configured queries. Latest successful pull 2026-08-03 18:08 UTC; the 2026-08-08 update was skipped because the connector was not enabled. Evidence at [/sources/web-search.md](/sources/web-search.md). |
+| Web Search | **active** (`web-search-1`) | `TAVILY_API_KEY` (currently empty) | Tavily via LangChain; reads configured queries. Latest successful pull 2026-08-03 18:08 UTC; the 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, 2026-08-17, 2026-08-18, 2026-08-19, 2026-08-20, and 2026-08-21 update attempts were skipped because the connector was not enabled in the runtime registry (ninth consecutive skip on the same code path; nightly searxng-fallback slot for 2026-08-20 is also empty on disk). Evidence at [/sources/web-search.md](/sources/web-search.md). |
-| Hacker News | **active** (`hackernews-1`) | _(public, no auth)_ | Public feeds (`top`, `new`, `best`) + Algolia HN search queries. Source-specific query set: `organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents` (LLM-agent topics per the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories"). Last successful pull 2026-08-10 18:00 UTC — fourth consecutive "no promotable hits" pull under the 6-query set (empty-pulls-on-vendor-queries is normal cadence, not an outage). Evidence at [/sources/hackernews.md](/sources/hackernews.md). |
+| Hacker News | **active** (`hackernews-1`) | _(public, no auth)_ | Public feeds (`top`, `new`, `best`) + Algolia HN search queries. Source-specific query set: `organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents` (LLM-agent topics per the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories"). Last successful pull 2026-08-21 18:00 UTC — **tenth pull since 2026-08-07 with an empty / noise-only Algolia lane on vendor queries** (after the 2026-08-08 03:15 + 2026-08-08 18:00 + 2026-08-13 + 2026-08-15 + 2026-08-16 + 2026-08-18 + 2026-08-19 fully-zero pulls + the 2026-08-10 + 2026-08-12 + 2026-08-17 + 2026-08-20 noise-only pulls where vendor queries returned substring-fragment noise; the **2026-08-21 pull returns to fully-zero across all four vendor queries + both workflow queries — a stricter "all-zero Algolia lane" than the 2026-08-20 noise-only lane**, with no application-domain thematic hits to soften the absence; empty-pulls-on-vendor-queries is normal cadence, not an outage). The strongest named-stack-adjacent item of the pull is `49386163` "DeepSeek-v4-flash-vision-exp" 379 pts top+best (DeepSeek vision capability extension; DeepSeek V4 Flash is the canonical DeepSeek-M3 comparison benchmark cited on the `MiniMax-m3` row via benchlm.ai 2026-08-01 + the unsloth `unsloth/DeepSeek-V4-Flash-GGUF` quantized local-LLM run path; V4 vision is a V4-Flash capability milestone that expands into the same multimodal territory MiniMax-M3 occupies per the MyClaw.ai 2026-07-29 confirmation); three secondary adjacents flagged for traceability: `49390739` Show HN Proliferate 11 pts (self-hostable "Codex for any coding agent" — Codex CLI is on Robin's named stack so this is the strongest named-stack direct cross-walk of the pull by name, but Proliferate is not on the named stack and 11-pt engagement is below the 21-pt OneCLI / 19-pt machine0 / 46-pt MCP Memory / 100-pt vendor release bar; adjacent-not-promoted per scope), `49378957` "The August 17 outage" 617 pts best / 722 cmts (GitHub post-mortem; off-scope per scope but the highest-engagement infrastructure post-mortem of the pull), `49390463` "Building an (almost) fully self-hosted, sandboxed, agentic software factory" 16 pts top (4th entry in the 5-day self-hosted-agentic-substrate cluster after DeepSeek Harness 2026-08-13 + machine0 2026-08-18 + OneCLI 2026-08-19 — cluster is now a recurring-signal watchlist candidate). The 2026-08-20 pull (prior) produced the `class-organoid-3d-bioprinting` theme-row Last-seen refresh 2026-08-12 → 2026-08-20 via the recurrence criterion (the `49366519` Nature organoid-time-passage paper 18 pts + `49373812` Science Alert cross-walk — second neural-organoid HN signal in 9 pulls); that refresh carries forward unchanged into the 2026-08-21 pull (no organoid / 3D-bioprinting item on the 2026-08-21 pull). All four 2026-08-21 adjacents stay adjacent-not-promoted per scope discipline. Evidence at [/sources/hackernews.md](/sources/hackernews.md). |
-| Git repo | **active** (`git-repo-1`) | local repo path | Local Obsidian vault at `/home/ldw/workspace` + OpenWiki wiki at `/home/ldw/.openwiki/wiki` (two configured repos per `~/.openwiki/connectors/git-repo/config.json`). Writes compact manifest; repo itself is source of truth. Evidence at [/sources/git-repo.md](/sources/git-repo.md). Last updated 2026-08-08 18:11 UTC. |
+| Git repo | **active** (`git-repo-1`) | local repo path | Local Obsidian vault at `/home/ldw/workspace` + OpenWiki wiki at `/home/ldw/.openwiki/wiki` (two configured repos per `~/.openwiki/connectors/git-repo/config.json`). Writes compact manifest; repo itself is source of truth. Evidence at [/sources/git-repo.md](/sources/git-repo.md). Last updated 2026-08-21 18:09 UTC — **0 new vault commits in the 24-hour window** (vault silent for the 5th consecutive fetch; the 2026-08-16 Quintard 2024 + Guo 2026 cluster remains the most recent vault activity, **5 calendar days stale**); 2 new automated wiki commits since the 2026-08-20 fetch (`b6dc337` daily update 2026-08-21 + `f6c2576` sources-sync 2026-08-21, the **seventh** consecutive sources-sync re-applying the 2026-08-15 count-data wipe pattern after `997b648` 2026-08-16 + `be49285` 2026-08-17 + `1fc73ae` 2026-08-18 + `dcb53a2` 2026-08-19 + `bd30339` 2026-08-20 + now `f6c2576` 2026-08-21). |
 ## How new source pages get created
@@ -39,4 +40,4 @@ When a connector ingests for the first time, an update run will:
 2. Create `/sources/<connector>.md` with the ingestion manifest, freshness, and compact evidence notes.
 3. Route durable items into the canonical pages and add a row in `/themes.md` if a recurring signal emerges.
-Until then, the new connector only has a row in the active connectors table above and no evidence page of its own..
+Until then, the new connector only has a row in the active connectors table above and no evidence page of its own..its own..
@@ -1,7 +1,8 @@
 ---
 type: "Reference"
 title: "飞书邮箱 (Robin customer mailbox)"
-openwiki_generated: true
+description: "Planned cross-agent mailbox sync target for Robin's Feishu (飞书) mailbox (imap.feishu.cn:993 / imap.larksuite.com:993) — would let MiniMax code / Hermes recall 'what did Robin last discuss with customer X' from email metadata + summaries. Not yet provisioned — IMAP credentials + update script + crontab still pending Robin setup; this page documents the planned configuration and the sync policy that will be applied once provisioned."
 tags: [feishu-mail, evidence-index, source, mailbox, planned, 2026-08-13]
 ---
 # 飞书邮箱 (Robin customer mailbox)
@@ -1,28 +1,29 @@
 # Files
- [4-27 SOP 实战 vs 实现差异 (2026-07-27 Tasevska 2025 重做教训)](2026-07-27-4-27-sop-vs-implementation.md)
+- [4-27 SOP 实战 vs 实现差异 (2026-07-27 Tasevska 2025 重做教训)](2026-07-27-4-27-sop-vs-implementation.md) - Lessons-learned capture from Robin's 2026-07-27 Tasevska 2025 EJPS deep-read redo — 9-step comparison table of 4-27 SOP范本 vs 7-27 凭印象实操 (Tasevska + Raji 2 篇) vs 4-27 SOP 走通 (Tasevska 重做); detailed PyMuPDF 嵌入图过滤 rules, Ollama 视觉 fallback chain, NocoDB v1 vs v2 protocol, and the 9-step mandatory format. Applies to every literature-deep-read invocation. Companion to `/sources/ldr-report-template.md`.
 - [Agents 代理商档案索引 — 跨 agent CRM 同步](agents.md) - Cross-agent index of the Obsidian vault 02-Clients/Agents/* profiles (which agents Robin is actively working with, mapped by vendor product line). Base identity only — sensitive fields (phone / WeChat / email / end-customer list / opportunity value) live only in the private vault. Updated 2026-08-07 with _known_associations.md product-line → agent → end-customer mapping.
 - [全国经销商地图 (2026-08-07 时点)](distributors-china-2026.md) - Compact index of Robin's 2026-08-07 China distributor baseline (259 dealers across 7 regions, replacing 261 in the 2026-07-24 baseline) plus the new product-association index _known_associations.md. Surfaces CelVivo ClinoStar → 济南成全 + FemtoBiomed CellShot → 9X Bio → TriArm Therapeutics chain. Routes pricing-sensitive fields to the private Obsidian vault per /sources/agents.md privacy rule.
- [飞书邮箱 (Robin customer mailbox)](feishu-mail.md)
+- [飞书邮箱 (Robin customer mailbox)](feishu-mail.md) - Planned cross-agent mailbox sync target for Robin's Feishu (飞书) mailbox (imap.feishu.cn:993 / imap.larksuite.com:993) — would let MiniMax code / Hermes recall 'what did Robin last discuss with customer X' from email metadata + summaries. Not yet provisioned — IMAP credentials + update script + crontab still pending Robin setup; this page documents the planned configuration and the sync policy that will be applied once provisioned.
- [Git repo — evidence index (Obsidian vault, Robin)](git-repo.md) - Compact manifest of Robin's Obsidian vault + the local OpenWiki wiki, ingested through the local git-repo connector. Two configured repos: obsidian-vault at /home/ldw/workspace (main branch, HEAD d97b39ed, 2026-08-10) and openwiki-wiki at /home/ldw/.openwiki/wiki (main branch, HEAD 2bc03f3, 2026-08-09). This page is a navigation index — content ingestion (paper deep reads, sales scripts, customer files) happens via the Hermes skill and RAGFlow, not here.
+- [Git repo — evidence index (Obsidian vault, Robin)](git-repo.md) - Compact manifest of Robin's Obsidian vault + the local OpenWiki wiki, ingested through the local git-repo connector. Two configured repos: obsidian-vault at /home/ldw/workspace (main branch, HEAD a4fa5a32, 2026-08-16, **0 new vault commits in the 2026-08-20T18:09Z → 2026-08-21T18:09Z 24-hour window — vault is silent for the 5th consecutive fetch after the 2026-08-16 Quintard + Guo cluster, 5 calendar days stale**) and openwiki-wiki at /home/ldw/.openwiki/wiki (main branch, HEAD f6c2576, 2026-08-21, **2 new automated wiki commits in the 2026-08-20T18:09Z → 2026-08-21T18:09Z window: `b6dc337` daily update 2026-08-21 + `f6c2576` sources-sync 2026-08-21 — the seventh consecutive sources-sync re-applying the 2026-08-15 count-data wipe pattern**). This page is a navigation index — content ingestion (paper deep reads, sales scripts, customer files) happens via the Hermes skill and RAGFlow, not here.
 - [Hacker News — evidence index](hackernews.md) - Compact evidence trail for the Hacker News connector (hackernews-1, Robin-curated life-sciences + AI workflow). Synthesis lives on /themes.md, /commitments.md, etc.; this page only records ingestion coverage and notable items.
- [文献精读 Master Template (Robin 7-27 实战版, "真适合浏览" 1 文件)](ldr-report-template.md)
+- [文献精读 Master Template (Robin 7-27 实战版, "真适合浏览" 1 文件)](ldr-report-template.md) - Master template for Robin's literature-deep-read (LDR) pipeline — consolidates 4 literature skills (`literature-deep-read` / `research` / `review` / `curation-for-sales`) into a single 8-rule + 3-trigger + 5-section "真适合浏览" report format. Synthesized from 4-27 SOP范本 + 7-27 实战 lessons (Tasevska / Raji / Bosnjakovic). Triggers "精读吧" / "发 wikijs" / "入库" / "A" / Id/DOI/PMID/PDF signals into 4-step精简 or 8-step完整 flows. PDF全文必传 + PyMuPDF xref去重 + 9项强制 + SeaFile hostname `fb.biokingdom.top` + NocoDB v1 JSON + 3张真图 + `journal-year-topic` 报告路径.
- [Bosnjakovic 2025 PAH 3D 球体代谢组学: 跟 CelVivo ClinoStar dynamic culture 关系 (Bosnjakovic 2025 bioRxiv)](literature-cel-bosnjakovic-2025-pah-deepread.md)
+- [Bosnjakovic 2025 PAH 3D 球体代谢组学: 跟 CelVivo ClinoStar dynamic culture 关系 (Bosnjakovic 2025 bioRxiv)](literature-cel-bosnjakovic-2025-pah-deepread.md) - Deep-read synthesis of Bosnjakovic A et al. 2025 bioRxiv preprint (DOI 10.1101/2025.07.10.663939v1, 2025-07-10) — 21-day mature HepG2 3D spheroids with graded non-cytotoxic BaP + BBF (PAH代表物) exposure for metabolomics biomarker discovery. Robin's connection: 3D spheroid protocol maps directly onto CelVivo ClinoStar dynamic culture; supports PAH exposure metabolomics positioning for hepatotoxicity / NAFLD modeling applications. 精读 2026-07-27.
- [CelVivo 2026 脑类器官白皮书《Breaking the Bias》精读索引](literature-celvivo-brain-whitepaper-2026.md)
+- [CelVivo 2026 脑类器官白皮书《Breaking the Bias》精读索引](literature-celvivo-brain-whitepaper-2026.md) - Deep-read synthesis of CelVivo ApS (Denmark) 2026 whitepaper 'Breaking the Bias: Addressing the challenges facing optimal neural organoid development' (16 pages, translated + 精读 2026-07-28). Synthesizes CelVivo's positioning on neural organoid long-term culture and the clinical-translation path. Direct vendor-channel evidence for the CelVivo ClinoStar / ClinoReactor portfolio on brain organoid applications — companion to academic literature flywheel-sync.
 - [Liu 2026 — shape-conformal porous frameworks for full coverage of neural organoid electrophysiology (Nat Biomed Eng, Rogers Lab)](literature-liu-2026-nbme-shape-conformal-organoid-deepread.md) - Deep-read synthesis of Liu N et al. (2026) Nature Biomedical Engineering — shape-conformal porous framework + adaptive genetic algorithm + flexible-electronics microlattice for full-surface (>90%) neural organoid electrophysiology at 3000-8000 channels per organoid (vs 200-1000 traditional MEA); weeks-long stable recording; epilepsy/AD disease modeling.
 - [Miao 2025 — co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids (Cell v2)](literature-miao-2025-cell-vascularization-v2-deepread.md) - Deep-read synthesis of Miao Y et al. (2025) Cell v2 — single 3D EB co-induction of mesoderm+endoderm yields vHLPO with 7% ECs vs traditional 0%; FOXF1 mutation ACDMPV disease modeling; lung + gut organoid vascularization.
- [Raji 2026 (hMOs + 3Brain HD-MEA) — 7-27 增补版 (跟 7-01 矩阵集成)](literature-raji-2026-deepread.md)
+- [Raji 2026 (hMOs + 3Brain HD-MEA) — 7-27 增补版 (跟 7-01 矩阵集成)](literature-raji-2026-deepread.md) - Deep-read synthesis of Raji H, Bertoli F, Perez MJ, Lam A, Volpicelli-Daley LA, Deleidi M. 2026 Molecular Psychiatry (Nature 子刊, s41380-026-03667-4, DOI 10.1038/s41380-026-03667-4, IF 11) — human midbrain organoids (hMOs) with WNT modulation, dopaminergic neuron differentiation, bioreactor culture, and 3Brain HD-MEA electrophysiology for Parkinson's disease modeling. 7-01 实战范本 (page 1622) + 7-27 增补版 integrated with 3-paper 3Brain MEA matrix (Raji / Pali / Wei) and 4 product-line complementarity chain (CelVivo ClinoStar + Cellink BIO X + 3Brain HD-MEA + FemtoBiomed CellShot).
 - [Sharma 2026 — vascularized retinal organoid RGC survival and maturation (Cell Stem Cell)](literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md) - Deep-read synthesis of Sharma K et al. (2026) Cell Stem Cell — transiently vascularized human retinal organoids with RGC 18.2% vs ctrl-RO 1.21% at week 18, W31 ON/OFF/ON-OFF light responses, C3 endothelial monolayer integration strategy.
- [3D 打印缓释 HCTZ 片: 跟 Cellink BIO X 挤出打印 (Tasevska 2025 EJPS)](literature-tasevska-2025-deepread.md)
+- [3D 打印缓释 HCTZ 片: 跟 Cellink BIO X 挤出打印 (Tasevska 2025 EJPS)](literature-tasevska-2025-deepread.md) - Deep-read synthesis of Tasevska T et al. 2025 European Journal of Pharmaceutical Sciences 206:106998 (DOI 10.1016/j.ejps.2024.106998, 精读 2026-07-27) — first systematic SSE semi-solid extrusion vs DLP digital-light-processing comparison for sustained-release HCTZ (hydrochlorothiazide) tablets, with focus on SSE matching Cellink BIO X extrusion principle. Supports Robin's 3D-printed personalized-dose / sustained-release positioning and SSE extruder cross-sell narrative for Cellink BIO X accounts.
- [Literature Deep-Reads — cross-agent deep-read index](literature.md) - Cross-agent index of Robin's literature deep-reads across the 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed) and adjacent application domains. Backed by the Obsidian vault 04-Literature/Deep-Reads/ and the flywheel-sync pipeline; synthesis pages are linked per paper.
+- [Literature Deep-Reads — cross-agent deep-read index](literature.md) - Cross-agent index of Robin's literature deep-reads across the 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed) and adjacent application domains (organoid IRB / ethics, vascularized organoids, microfluidic / organ-on-chip). Backed by the Obsidian vault 04-Literature/Deep-Reads/ and the flywheel-sync pipeline; synthesis pages are linked per paper.
 - [NocoDB 文献库索引 — 跨 agent 数据层](nocodb.md)
- [OpenWiki 速查手册 (Robin 一次聊清, 直接拿来用)](OpenWiki%E9%80%9F%E6%9F%A5%E6%89%8B%E5%86%8C.md)
+- [OpenWiki Upgrade Drift (auto-generated)](openwiki-version-drift.md)
- [RAGFlow 文档采样索引](ragflow-documents.md)
+- [OpenWiki 速查手册 (Robin 一次聊清, 直接拿来用)](OpenWiki%E9%80%9F%E6%9F%A5%E6%89%8B%E5%86%8C.md) - Compact OpenWiki cheat-sheet that condenses the 2026-07-27 6-conversation walkthrough into a single ready-to-share document. Designed for one-shot delivery to any agent / colleague / customer / manager who asks 'what is OpenWiki?' — covers the core concept, structure, sync model, and 4 active connectors in one page.
 - [RAGFlow 文档采样索引](ragflow-documents.md) - Document-level sample index of Robin's RAGFlow instance (http://10.10.10.254:9980) — 18 KBs / 32709 total docs / 401 sample entries (last sync 2026-08-03). Captures the 30-doc-per-request server-side limit + offset bug that forces 12 large KBs to single-page samples. Lets MiniMax code / Hermes see 'what's in each KB' without SQL queries; complements `/sources/ragflow.md` (KB-level health + counts).
 - [RAGFlow 全文检索索引 (Robin KB system)](ragflow.md)
 - [Sources](README.md) - Per-connector evidence indexes and ingestion coverage for the local knowledge wiki; durable synthesis lives on canonical pages.
- [RustDesk 自建 hbbs 完整配置笔记 (2026-08-05)](rustdesk-sop.md)
+- [RustDesk 自建 hbbs 完整配置笔记 (2026-08-05)](rustdesk-sop.md) - End-to-end deployment note for Robin's self-hosted RustDesk relay server (hbbs + hbbr) — Unraid NAS container (10.10.10.254) + OpenWrt reverse-proxy (10.10.10.252) + Tencent Light Cloud (43.160.207.177) + ITX client (192.168.31.14), with permanent password + key config. Supports remote control of the ITX 24h host (per `/commitments.md` `itx-24h-host-build-2026-q3`) and Robin's travel-laptop remote-access workflow.
- [CelVivo 销售弹药清单 (2026-07-16 实战索引)](sales-ammunition.md)
+- [CelVivo 销售弹药清单 (2026-07-16 实战索引)](sales-ammunition.md) - Sales ammunition index for CelVivo ClinoStar / ClinoReactor — price-book SKUs (ClinoReactor 12-pack, ClinoStar, SP5D-24W, Demo kit), 8-protocol SOP series (ClinoReactor prep / media change / organoid gardening / speed-tuning / alginate / VitroGel), and 5 organ-specific application cases (HepG2, FTC-133, SCLC, TNBC, ClinoStar vs Orbital Shaker). Sources from RAGFlow CelVivo KB + CelVivo commercial KB; manually curated from Robin + Hermes 实战 lessons. Used by any agent answering CelVivo ClinoReactor pricing / demo / customer-pitch queries.
 - [SeaFile 大文件存储索引](seafile.md)
- [CelVivo + Vault 实时 mtime 快照 (2026-07-16 快照)](vault-mtime-snapshot-2026-07-16.md)
+- [CelVivo + Vault 实时 mtime 快照 (2026-07-16 快照)](vault-mtime-snapshot-2026-07-16.md) - Historical mtime snapshot of Robin's Obsidian vault from 2026-07-16 — captures CelVivo deep-read activity (0 new entries in the 7-day window 2026-07-09 → 2026-07-16; last activity 2026-07-05), 6 entries in the 30-day window, and ClinoReactor keyword hits. Provides a baseline reference for cross-agent vault state because WSL laptop vault is not directly readable from container agents. Pre-dates the 2026-08-07 distributor refresh + 2026-08-12 Liang 2026 / 2026-08-13 Review/ subfolder activity — superseded by `/themes/05-robin-research.md` for current vault state.
 - [Web Search Evidence](web-search.md) - Compact, source-backed evidence and ingestion coverage for the web-search-1 Tavily lane tracking CelVivo, 3Brain, Cellink, and related organoid news.
 - [Wiki.js 索引 — 跨 agent 文档发布层](wikijs.md)
@@ -1,7 +1,8 @@
 ---
 type: "Reference"
 title: "文献精读 Master Template (Robin 7-27 实战版, \"真适合浏览\" 1 文件)"
-openwiki_generated: true
+description: "Master template for Robin's literature-deep-read (LDR) pipeline — consolidates 4 literature skills (`literature-deep-read` / `research` / `review` / `curation-for-sales`) into a single 8-rule + 3-trigger + 5-section \"真适合浏览\" report format. Synthesized from 4-27 SOP范本 + 7-27 实战 lessons (Tasevska / Raji / Bosnjakovic). Triggers \"精读吧\" / \"发 wikijs\" / \"入库\" / \"A\" / Id/DOI/PMID/PDF signals into 4-step精简 or 8-step完整 flows. PDF全文必传 + PyMuPDF xref去重 + 9项强制 + SeaFile hostname `fb.biokingdom.top` + NocoDB v1 JSON + 3张真图 + `journal-year-topic` 报告路径."
 tags: [ldr-template, literature-deep-read, sop, reference, 2026-08-13]
 ---
 # 文献精读 Master Template (Robin 7-27 实战版, "真适合浏览" 1 文件)
@@ -1,7 +1,8 @@
 ---
 type: "Reference"
 title: "Bosnjakovic 2025 PAH 3D 球体代谢组学: 跟 CelVivo ClinoStar dynamic culture 关系 (Bosnjakovic 2025 bioRxiv)"
-openwiki_generated: true
+description: "Deep-read synthesis of Bosnjakovic A et al. 2025 bioRxiv preprint (DOI 10.1101/2025.07.10.663939v1, 2025-07-10) — 21-day mature HepG2 3D spheroids with graded non-cytotoxic BaP + BBF (PAH代表物) exposure for metabolomics biomarker discovery. Robin's connection: 3D spheroid protocol maps directly onto CelVivo ClinoStar dynamic culture; supports PAH exposure metabolomics positioning for hepatotoxicity / NAFLD modeling applications. 精读 2026-07-27."
 tags: [literature-deep-read, celvivo-clinostar, hepG2, PAH, metabolomics, 3d-spheroid, 2026-08-13]
 ---
 # Bosnjakovic 2025 PAH 3D 球体代谢组学: 跟 CelVivo ClinoStar dynamic culture 关系 (Bosnjakovic 2025 bioRxiv)
@@ -1,7 +1,8 @@
 ---
 type: "Reference"
 title: "CelVivo 2026 脑类器官白皮书《Breaking the Bias》精读索引"
-openwiki_generated: true
+description: "Deep-read synthesis of CelVivo ApS (Denmark) 2026 whitepaper 'Breaking the Bias: Addressing the challenges facing optimal neural organoid development' (16 pages, translated + 精读 2026-07-28). Synthesizes CelVivo's positioning on neural organoid long-term culture and the clinical-translation path. Direct vendor-channel evidence for the CelVivo ClinoStar / ClinoReactor portfolio on brain organoid applications — companion to academic literature flywheel-sync."
 tags: [literature-deep-read, celvivo, brain-organoid, clinostat, long-term-culture, whitepaper, vendor-channel, 2026-08-13]
 ---
 # CelVivo 2026 脑类器官白皮书《Breaking the Bias》精读索引
@@ -1,7 +1,8 @@
 ---
 type: "Reference"
 title: "Raji 2026 (hMOs + 3Brain HD-MEA) — 7-27 增补版 (跟 7-01 矩阵集成)"
-openwiki_generated: true
+description: "Deep-read synthesis of Raji H, Bertoli F, Perez MJ, Lam A, Volpicelli-Daley LA, Deleidi M. 2026 Molecular Psychiatry (Nature 子刊, s41380-026-03667-4, DOI 10.1038/s41380-026-03667-4, IF 11) — human midbrain organoids (hMOs) with WNT modulation, dopaminergic neuron differentiation, bioreactor culture, and 3Brain HD-MEA electrophysiology for Parkinson's disease modeling. 7-01 实战范本 (page 1622) + 7-27 增补版 integrated with 3-paper 3Brain MEA matrix (Raji / Pali / Wei) and 4 product-line complementarity chain (CelVivo ClinoStar + Cellink BIO X + 3Brain HD-MEA + FemtoBiomed CellShot)."
 tags: [literature-deep-read, 3brain-hd-mea, midbrain-organoid, parkinson, dopaminergic-neuron, bioreactor, 2026-08-13]
 ---
 # Raji 2026 (hMOs + 3Brain HD-MEA) — 7-27 增补版 (跟 7-01 矩阵集成)
@@ -1,7 +1,8 @@
 ---
 type: "Reference"
 title: "3D 打印缓释 HCTZ 片: 跟 Cellink BIO X 挤出打印 (Tasevska 2025 EJPS)"
-openwiki_generated: true
+description: "Deep-read synthesis of Tasevska T et al. 2025 European Journal of Pharmaceutical Sciences 206:106998 (DOI 10.1016/j.ejps.2024.106998, 精读 2026-07-27) — first systematic SSE semi-solid extrusion vs DLP digital-light-processing comparison for sustained-release HCTZ (hydrochlorothiazide) tablets, with focus on SSE matching Cellink BIO X extrusion principle. Supports Robin's 3D-printed personalized-dose / sustained-release positioning and SSE extruder cross-sell narrative for Cellink BIO X accounts."
 tags: [literature-deep-read, cellink-bio-x, 3d-printing, HCTZ, sustained-release, SSE, DLP, 2026-08-13]
 ---
 # 3D 打印缓释 HCTZ 片: 跟 Cellink BIO X 挤出打印 (Tasevska 2025 EJPS)
@@ -1,7 +1,7 @@
 ---
 type: "Reference"
 title: "Literature Deep-Reads — cross-agent deep-read index"
-description: "Cross-agent index of Robin's literature deep-reads across the 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed) and adjacent application domains. Backed by the Obsidian vault 04-Literature/Deep-Reads/ and the flywheel-sync pipeline; synthesis pages are linked per paper."
+description: "Cross-agent index of Robin's literature deep-reads across the 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed) and adjacent application domains (organoid IRB / ethics, vascularized organoids, microfluidic / organ-on-chip). Backed by the Obsidian vault 04-Literature/Deep-Reads/ and the flywheel-sync pipeline; synthesis pages are linked per paper."
 tags: [literature, deep-read, flywheel, celvivo, 3brain, cellink, femtobiomed]
 ---
@@ -13,6 +13,13 @@ tags: [literature, deep-read, flywheel, celvivo, 3brain, cellink, femtobiomed]
 ## Last 30 days of deep reads (mtime descending)
 ### 2026-08-16 (Quintard 2024 + Guo 2026 — 2 papers on the same day)
 | DOI | Vendor | Application | Title (short) | Vault path |
 | --- | --- | --- | --- | --- |
 | `10.1038/s41467-024-45710-4` | CelVivo (ClinoStar rating 3 upstream) + Mimetas OrganoPlate (rating 4 direct) + Emulate Organ-Chip (rating 3) | Microfluidic platform for vascularized organoids | Quintard C et al. (2024) A microfluidic platform integrating functional vascularized organoids-on-chip (Nat Commun; 10 通道并行微流控芯片 + U 型捕获位 + hiPSC-BVO 30 天功能性灌注培养 + 跨类器官验证 [间充质球体 / BVO / 胰岛球体 / 肺类器官]; 血管层级化 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管, 壁剪切 27-2000 s⁻¹ 完美匹配人体毛细血管生理范围 50-1900 s⁻¹) — Wiki.js IDs 1719/1720/1722, NocoDB Id 3297; 4-commit LDR cycle 2026-08-16 (`0fc8db24` → `290e9635` → `24c713de` → `4073abf4`); last commit deleted the 3Brain reference per the SOP "硬门槛合规修正" cleanup rule | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` |
 | `10.3389/fcell.2026.1721946` | CelVivo (ClinoStar rating 4 clinical-translation IRB) + Mimetas OrganoPlate (rating 4 co-culture ethics) + Emulate Organ-Chip (rating 3) | Organoid research IRB / ethics systematic review | Guo Z & Zhang N (2026) Ethical review key considerations for organoid applications in biomedical research—a systematic review (Front Cell Dev Biol; 嘉兴市第一医院 + 嘉兴大学医学院视角; 类器官研究 IRB / 伦理审查 7 大强制要点系统综述 [样本来源/知情同意/数据隐私/共培养主体性/3R 动物福利/跨境监管/长期保存与终止使用] + 5 国对照 [中国《人类遗传资源管理条例》+《涉及人的生命科学和医学研究伦理审查办法》2023 / 美国 HIPAA + Common Rule + NIH GDS / 欧盟 GDPR + Clinical Trials Regulation 536/2014 / 日本 / 韩国]) — Wiki.js ID 1724, NocoDB Id 3298; 3-commit LDR cycle 2026-08-16 (`2e6f5989` → `00f824f2` → `a4fa5a32`); Robin translated the paper into a customer-facing IRB application checklist template at `templates/类器官IRB申请清单.md` v1.0 (180 lines; 7 mandatory points + 5 customer Q&A + China vs International flow + 10 attachments + 7 citations) | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` |
 ### 2026-08-09
 | DOI | Vendor | Application | Title (short) | Vault path |
@@ -178,9 +185,50 @@ The `Robin_Picked_Papers` table is **new as of today** — created per Robin's 2
 - **Authors**: Yang J, Zhang X, Li S, Gao Z
 - **Journal**: Cells 2026, 15(8), 703 (MDPI, IF ~5.1, CC-BY OA)
 - **DOI**: 10.3390/cells15080703
- **Wiki.js**: [ID 1708](https://hb.biokingdom.top/wiki/organoid/ovb-cerebral-organoid-multiscale-2026)
+- **Wiki.js**: [ID 1708](http://10.10.10.254:3000/zh/organoid/ovb-cerebral-organoid-multiscale-2026)
 - **NocoDB Id**: 1103
- **PDF**: SeaFile 文献库 7 张整页配图(qwen2.5vl:7b 视觉审核通过)
+- **PDF**: [cells_15_00703.pdf](https://fb.biokingdom.top/f/582d1f055f6e4365a924/?raw=1) + 10 张真实配图(xref extract)
- **Key finding**: 首次标准化 OVB-类器官(视泡-大脑)vs 大脑类器官多尺度对比;Day 30 FOXG1+VSX2 共表达;TEM 突触+髓鞘;1,625/2,924 DEGs
+- **Key finding**: Cells 2026 重磅 - OVB-organoids vs Cerebral 多尺度对比(中国军事医学科学院); Day 30 FOXG1+53.86% + VSX2+4.18%; TEM 突触+髓鞘; 1625 上调 + 2924 下调 DEGs; CHRNB2 6.5 倍差异; KEGG 富集到神经突触功能 vs 免疫炎症代谢
 - **Business relevance**: OVB-organoids + 3Brain MEA = 眼-脑协同发育研究完整解决方案
 - **Tags**: OVB-organoids, cerebral-organoids, brain-development, retinal-organoid, FOXG1, VSX2
 ### 2026-08-11 - PMID 41909700
 - **Title**: Organoid-microglia system for modeling the immune microenvironment of the brain and retina
 - **Authors**: Yu J, Tang B, Gu Z, Wang G, Liu A
 - **Journal**: Frontiers in Immunology 2026, 17:1747589
 - **DOI**: 10.3389/fimmu.2026.1747589
 - **Wiki.js**: [ID 1709](http://10.10.10.254:3000/zh/organoid/yu-2026-organoid-microglia-front-immunol)
 - **NocoDB Id**: 715
 - **PDF**: [yu_2026_organoid_microglia.pdf](https://fb.biokingdom.top/f/4537d08bf4d14c6db0bc/?dl=1) + 4 张真图
 - **Key finding**: 类器官-小胶质细胞共培养 3 大策略 + 6 大应用 (AD/ASD/视网膜/药筛/CRISPR/OoC); 神经-免疫体外模型空白填补
 - **Business relevance**: 3Brain MEA + CelVivo ClinoStar + Femtobiomed CellShot + Cellink BIO X 4 大产品线全交叉
 - **Tags**: 类器官, 小胶质细胞, 神经免疫, 脑-视网膜, 共培养
 ### 2026-08-11 - PMID 41686639
 - **Title**: High-throughput engineered tumor organoids reveal ROCK signaling as an immunotherapeutic target in triple-negative breast cancer
 - **Authors**: Zhou X, Zhu Y, Nicolas G, Wang Z, Lobie P, Ma S
 - **Journal**: Cell Reports 2026, 45:116987
 - **DOI**: 10.1016/j.celrep.2026.116987
 - **Wiki.js**: [ID 1710](http://10.10.10.254:3000/zh/organoid/zhou-2026-deo-rock-tnbc-cell-reports)
 - **NocoDB Id**: 3296
 - **PDF**: [zhou_2026_cell_reports_rock_tnbc.pdf](https://fb.biokingdom.top/f/bbe6f494811047c2bba0/?dl=1) + 6 张真图
 - **Key finding**: DEO 平台保留 TNBC 患者内源 TIL;ROCK 通路激动剂戊酸(PA)维持 TIL + 协同 anti-PD-1 解除 BLIS 亚型免疫抑制(联合治疗肿瘤抑制率 ~70%)
 - **Business relevance**: 4 大产品线全交叉 (CelVivo ClinoStar 培养/3Brain MEA 评估/Femtobiomed CellShot 基因编辑/Cellink BIO X 制造)
 - **Tags**: 肿瘤类器官, 三阴乳腺癌, ROCK信号, TIL, anti-PD-1, 戊酸, 马少华, BLIS亚型
 ### 2026-08-11 - PMID 41536916
 - **Title**: Artificial Intelligence Virtual Organoids (AIVOs)
 - **Authors**: Bai L, Su J
 - **Journal**: Bioactive Materials 2026 (IF 18.2)
 - **DOI**: 10.1016/j.bioactmat.2025.12.030
 - **Type**: Review
 - **Wiki.js**: [ID 1711](http://10.10.10.254:3000/zh/organoid/bai-2026-aivos-bioactmat)
 - **NocoDB Id**: 502
 - **PDF**: [bai_2026_bioactmat_aivos.pdf](https://fb.biokingdom.top/f/59c6a647037346a28197/?dl=1) + 6 张真图
 - **Key finding**: AI Virtual Organoids (AIVOs) = 物理类器官 + AI 数字孪生; 数据-模型-交互三层架构; 6 大临床应用方向
 - **Business relevance**: 4 大产品线 (CelVivo ClinoStar / 3Brain MEA / Femtobiomed CellShot / Cellink BIO X) 全部可对接 AIVOs 平台 = 完整 湿+干 实验方案
 - **Tags**: 综述, 类器官, 人工智能, 虚拟器官, 数字孪生, 多组学, Bioactive-Materials-2026
 | 10.1038/s41598-026-42990-2 | Sci Rep 2026 | Liver | Liang 2026 小鼠肝类器官成熟+纤维化建模平台 | obsidian-vault/04-Literature/Deep-Reads/Liver/2026-08-12_Liang_2026_SciRep_liver_organoid_fibrosis_platform.md |
@@ -3,7 +3,7 @@
 > 数据源: NocoDB 13 个文献库 + 2 个公司库 (实时,每次 OpenWiki cron 跑时更新)
 > 用途: MiniMax code / Hermes 跨 agent 问 "Robin 的 NocoDB 里有什么"
 > 更新: 自动（`~/.openwiki/update-sources.sh` 每天 02:30 拉一次,数据写入本页后 commit + push Gitea）
-> 上次同步: **2026-08-10T18:30:02Z** · **总记录数: 6613**
+> 上次同步: **2026-08-21T18:30:02Z** · **总记录数: 6620**
 ## 13 个文献库 (实测计数)
@@ -19,7 +19,7 @@
 | `m8abmmwrgchr9ni` | kidney_organoid_literature | 23 |
 | `mun191tsudjdtga` | retinal_organoid_literature | 4 |
 | `m65htyq25vmpysq` | Cellink_literature | 2499 |
-| `mri6u97xrxi0vvm` | organoid_literature (old) | 2779 |
+| `mri6u97xrxi0vvm` | organoid_literature (old) | 2786 |
 | `mr8wrky2um6gwev` | lung_organoid_literature | 48 |
 | `m76t4vsfar89w0h` | 3Brain_literature | 147 |
@@ -0,0 +1,18 @@
 ---
 type: Reference
 title: OpenWiki Upgrade Drift (auto-generated)
 last_checked: 2026-08-15T20:00:03Z
 ---
 # OpenWiki Upgrade Drift
 - Local installed: `v0.3.1`
 - npm latest: `v0.3.3`
 - Last checked: 2026-08-15T20:00:03Z
 ## Action (manual, no auto-upgrade)
 ```bash
 npm install -g openwiki@latest
 ```
 > **WARNING**: v0.3.1 → v0.4+ 可能有 breaking change. Read release notes first.
@@ -1,7 +1,8 @@
 ---
 type: "Reference"
 title: "RAGFlow 文档采样索引"
-openwiki_generated: true
+description: "Document-level sample index of Robin's RAGFlow instance (http://10.10.10.254:9980) — 18 KBs / 32709 total docs / 401 sample entries (last sync 2026-08-03). Captures the 30-doc-per-request server-side limit + offset bug that forces 12 large KBs to single-page samples. Lets MiniMax code / Hermes see 'what's in each KB' without SQL queries; complements `/sources/ragflow.md` (KB-level health + counts)."
 tags: [ragflow, evidence-index, source, kb-documents, sample, 2026-08-13]
 ---
 # RAGFlow 文档采样索引
@@ -3,7 +3,7 @@
 > 数据源: RAGFlow (http://10.10.10.254:9980/) 14 个 KB 全文检索结果
 > 用途: MiniMax code / Hermes 跨 agent 问 "Robin 的 RAGFlow 里有什么"
 > 更新: 自动同步可用性 + 手动维护 KB 列表
-> 上次同步: **2026-08-10T18:30:02Z** · landing 200 · /api/v1/datasets 401
+> 上次同步: **2026-08-21T18:30:02Z** · landing 200 · /api/v1/datasets 401
 ## RAGFlow 服务可用性
@@ -1,7 +1,8 @@
 ---
 type: "Reference"
 title: "RustDesk 自建 hbbs 完整配置笔记 (2026-08-05)"
-openwiki_generated: true
+description: "End-to-end deployment note for Robin's self-hosted RustDesk relay server (hbbs + hbbr) — Unraid NAS container (10.10.10.254) + OpenWrt reverse-proxy (10.10.10.252) + Tencent Light Cloud (43.160.207.177) + ITX client (192.168.31.14), with permanent password + key config. Supports remote control of the ITX 24h host (per `/commitments.md` `itx-24h-host-build-2026-q3`) and Robin's travel-laptop remote-access workflow."
 tags: [rustdesk, itx-24h-host, remote-access, sop, infra, 2026-08-13]
 ---
 # RustDesk 自建 hbbs 完整配置笔记 (2026-08-05)
@@ -1,7 +1,8 @@
 ---
 type: "Reference"
 title: "CelVivo 销售弹药清单 (2026-07-16 实战索引)"
-openwiki_generated: true
+description: "Sales ammunition index for CelVivo ClinoStar / ClinoReactor — price-book SKUs (ClinoReactor 12-pack, ClinoStar, SP5D-24W, Demo kit), 8-protocol SOP series (ClinoReactor prep / media change / organoid gardening / speed-tuning / alginate / VitroGel), and 5 organ-specific application cases (HepG2, FTC-133, SCLC, TNBC, ClinoStar vs Orbital Shaker). Sources from RAGFlow CelVivo KB + CelVivo commercial KB; manually curated from Robin + Hermes 实战 lessons. Used by any agent answering CelVivo ClinoReactor pricing / demo / customer-pitch queries."
 tags: [sales-ammunition, celvivo, clinoreactor, clinostar, evidence-index, 2026-08-13]
 ---
 # CelVivo 销售弹药清单 (2026-07-16 实战索引)
@@ -3,7 +3,7 @@
 > 数据源: SeaFile (http://10.10.10.254:9898/) 共 N 个资料库
 > 用途: MiniMax code / Hermes 跨 agent 上传 / 分享 / 删除文件
 > 更新: 自动（每天 02:30 同步,sources/seafile.md 刷新）
-> 上次同步: **2026-08-10T18:30:02Z** · 6 repos · 77.1 GB total
+> 上次同步: **2026-08-21T18:30:02Z** · 
 ## 配置 (v1.2 skill, 2026-07-16)
@@ -19,12 +19,7 @@
 | ID | 名称 | 大小 | 文件数 | 最后更新 | Owner |
 | --- | --- | --- | --- | --- | --- |
-| b845bc08-939d-4316-934e-d661a14e7724 | 文献库                  |    13.7 GB | 2026-08-09 | Eastway Lee    |
+
 | 5170c8b3-3c56-4092-bd19-d9776bf9cce0 | 产品库                  |   647.8 MB | 2026-08-05 | Eastway Lee    |
 | 537282e8-11ca-4b68-9f16-7c4e56976cf2 | 普瑞麦迪                 |    27.3 GB | 2026-05-27 | Eastway Lee    |
 | e99f456e-206b-4649-9de4-61a6d9ff0b12 | 汇佰生物                 |     4.1 GB | 2026-05-11 | Eastway Lee    |
 | 537282e8-11ca-4b68-9f16-7c4e56976cf2 | 普瑞麦迪                 |          ? | 2026-05-27 |                |
 | e99f456e-206b-4649-9de4-61a6d9ff0b12 | 汇佰生物                 |          ? | 2026-05-11 |                |
 ## 跟 LDR / Wiki.js / OpenWiki 集成
@@ -1,7 +1,8 @@
 ---
 type: "Reference"
 title: "CelVivo + Vault 实时 mtime 快照 (2026-07-16 快照)"
-openwiki_generated: true
+description: "Historical mtime snapshot of Robin's Obsidian vault from 2026-07-16 — captures CelVivo deep-read activity (0 new entries in the 7-day window 2026-07-09 → 2026-07-16; last activity 2026-07-05), 6 entries in the 30-day window, and ClinoReactor keyword hits. Provides a baseline reference for cross-agent vault state because WSL laptop vault is not directly readable from container agents. Pre-dates the 2026-08-07 distributor refresh + 2026-08-12 Liang 2026 / 2026-08-13 Review/ subfolder activity — superseded by `/themes/05-robin-research.md` for current vault state."
 tags: [vault-snapshot, mtime, celvivo, historical-baseline, 2026-08-13]
 ---
 # CelVivo + Vault 实时 mtime 快照 (2026-07-16 快照)
@@ -2,12 +2,69 @@
 type: "Reference"
 title: "Web Search Evidence"
 description: "Compact, source-backed evidence and ingestion coverage for the web-search-1 Tavily lane tracking CelVivo, 3Brain, Cellink, and related organoid news."
-tags: [source, web-search, tavily, celvivo, 3brain, cellink, organoids]
+tags: [source, web-search, tavily, celvivo, 3brain, cellink, organoids, 2026-08-12, 2026-08-15, 2026-08-16, 2026-08-17, 2026-08-18, 2026-08-19, 2026-08-20, 2026-08-21]
 timestamp: 2026-08-21T18:35:00Z
 ---
 # Web Search Evidence
-> Connector: `web-search-1` (Tavily). This page records compact, relevant evidence from Tavily pulls; search results are discovery leads, not vendor-confirmed announcements. Latest successful pull: 2026-08-03 18:08 UTC. The 2026-08-08 and 2026-08-10 update attempts were skipped because the connector is disabled and `TAVILY_API_KEY` is not present; no new 24-hour evidence was available on either run.
+> Connector: `web-search-1` (Tavily). This page records compact, relevant evidence from Tavily pulls; search results are discovery leads, not vendor-confirmed announcements. Latest successful pull: 2026-08-03 18:08 UTC. The 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, 2026-08-17, 2026-08-18, 2026-08-19, 2026-08-20, and 2026-08-21 update attempts were skipped because the connector is disabled and `TAVILY_API_KEY` is not present; no new 24-hour evidence was available on any of these nine runs.
 ## 2026-08-21 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. The nightly searxng-fallback slot (`~/.openwiki/connectors/web-search/raw/2026-08-20T18-35-03-searxng-fallback/`) is also empty (confirmed empty on disk) — no web-search evidence of any kind landed in the 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, 2026-08-17, 2026-08-18, 2026-08-19, and 2026-08-20 runs hit the same blocker; this is the **ninth consecutive skip on the same code path**. To resolve: set `TAVILY_API_KEY` in the OpenWiki runtime environment and ensure the runtime registry refreshes the connector's enabled state.
 ## 2026-08-20 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. The nightly searxng-fallback slot (`~/.openwiki/connectors/web-search/raw/2026-08-19T18-35-03-searxng-fallback/`) is also empty — no web-search evidence of any kind landed in the 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, 2026-08-17, 2026-08-18, and 2026-08-19 runs hit the same blocker; the 2026-08-21 run hit the same blocker too. This was the **eighth consecutive skip on the same code path at the time of the 2026-08-20 attempt** (and the ninth skip including the 2026-08-21 follow-up). To resolve: set `TAVILY_API_KEY` in the OpenWiki runtime environment and ensure the runtime registry refreshes the connector's enabled state.
 ## 2026-08-19 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. The nightly searxng-fallback slot (`~/.openwiki/connectors/web-search/raw/2026-08-18T18-35-03-searxng-fallback/`) is also empty — no web-search evidence of any kind landed in the 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, 2026-08-17, and 2026-08-18 runs hit the same blocker; the 2026-08-20 and 2026-08-21 runs hit the same blocker too. This was the **seventh consecutive skip on the same code path at the time of the 2026-08-19 attempt** (and the ninth skip including the 2026-08-20 and 2026-08-21 follow-ups). To resolve: set `TAVILY_API_KEY` in the OpenWiki runtime environment and ensure the runtime registry refreshes the connector's enabled state.
 ## 2026-08-18 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. The nightly searxng-fallback slot (`~/.openwiki/connectors/web-search/raw/2026-08-17T18-35-03-searxng-fallback/`) is also empty — no web-search evidence of any kind landed in the 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, and 2026-08-17 runs hit the same blocker; the 2026-08-19, 2026-08-20, and 2026-08-21 runs hit the same blocker too. This was the **sixth consecutive skip on the same code path at the time of the 2026-08-18 attempt** (and the ninth skip including the 2026-08-19, 2026-08-20, and 2026-08-21 follow-ups).
 ## 2026-08-17 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. The nightly searxng-fallback slot (`~/.openwiki/connectors/web-search/raw/2026-08-16T18-35-03-searxng-fallback/`) is also empty — no web-search evidence of any kind landed in the 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, 2026-08-12, and 2026-08-15 runs hit the same blocker; the 2026-08-18, 2026-08-19, 2026-08-20, and 2026-08-21 runs hit the same blocker too. This was the **fifth consecutive skip on the same code path at the time of the 2026-08-17 attempt** (and the ninth skip including the 2026-08-18, 2026-08-19, 2026-08-20, and 2026-08-21 follow-ups).
 ## 2026-08-15 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, and 2026-08-12 runs hit the same blocker; the 2026-08-17, 2026-08-18, 2026-08-19, 2026-08-20, and 2026-08-21 runs hit the same blocker too. This was the fourth consecutive skip on the same code path at the time of the 2026-08-15 attempt (and the ninth skip including the 2026-08-17, 2026-08-18, 2026-08-19, 2026-08-20, and 2026-08-21 follow-ups).
 ## 2026-08-12 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08 and 2026-08-10 runs hit the same blocker; this is the third consecutive skip on the same code path.
 ## 2026-08-10 attempted update — skipped
@@ -478,6 +535,7 @@ Every query in the 10-query lane returned the same structured error (no answer t
 - Pull 10: fetched 2026-08-02T18:07:53Z — raw `~/.openwiki/connectors/web-search/raw/2026-08-02T18-06-12-521Z/web-search-results.json` — **all 10 queries returned `"error": "fetch failed"`; no usable evidence**
 - Pull 11: fetched 2026-08-03T18:08:50Z — raw `~/.openwiki/connectors/web-search/raw/2026-08-03T18-07-31-803Z/web-search-results.json` — **first successful pull after the 3-day outage streak; Tavily back online; see section below**
 - Pull 12: attempted 2026-08-10T18:35Z — **skipped** (connector reported disabled; `TAVILY_API_KEY` not present; no raw files written; no synthesis update)
 - 2026-08-12 / 2026-08-15 / 2026-08-17 / 2026-08-18 / 2026-08-19 / 2026-08-20 / 2026-08-21 update attempts: all **skipped** on the same code path (connector reported disabled; `TAVILY_API_KEY` not present; no raw files written; no synthesis update; ninth consecutive skip including 2026-08-21); see individual sections above for per-day operational notes
 - Queries: pulls 1, 2, 4, 5, 6, 7, 8, 9, 10, 11 = 10 queries each; pull 3 = 6 queries (vendor-anchored only)
 - Instance: `web-search-1`
@@ -550,3 +608,25 @@ Eleventh Tavily pull, run as a stand-alone `openwiki personal --update` source i
 - **Tavily answer-text quality:** the 3Brain answer is now correct (first time in 11 pulls); the Cellink Lumen X answer is substantive; the Hermes/M3 answer is partially fabricated ("release date of June 1, 2026") — treat as untrusted. Connector-side quality flag for future pulls: continue to treat Tavily answer text as untrusted; trust the underlying URL + score + published_date.
 - **Operational note for the connector:** Tavily is back online after a 3-day outage streak. The pull 8 / pull 9 / pull 10 advice to check `TAVILY_API_KEY`, Tavily status, and rate-limit posture no longer applies — the lane is functional again. No connector-side configuration change is required.
 - **Coverage:** fetched `2026-08-03T18:08:50.866Z`; 10 queries; raw `~/.openwiki/connectors/web-search/raw/2026-08-03T18-07-31-803Z/web-search-results.json`; instance `web-search-1`.
 on the existing `3brain-coreplate-2026-conference-positioning` verification commitment. No new commitment; existing commitment Notes are extended.
  3. **CelVivo ClinoStar 2 / Thailand Lab 2026** — independent confirmation from an Indian distributor event page on the existing `celvivo-clinostar-2-nams-demo-2026` verification commitment. No new commitment; existing commitment Notes are extended.
 - **Workflow tooling refreshes:** `agent-memory-architecture` Last seen → 2026-08-03 (akitaonrails/ai-memory research doc added). `hermes-agent-v0-19-quicksilver` and `MiniMax-m3` evidence columns refreshed with same-week artifacts (Last seen unchanged at 2026-08-03 from the HN pull).
 - **Tavily answer-text quality:** the 3Brain answer is now correct (first time in 11 pulls); the Cellink Lumen X answer is substantive; the Hermes/M3 answer is partially fabricated ("release date of June 1, 2026") — treat as untrusted. Connector-side quality flag for future pulls: continue to treat Tavily answer text as untrusted; trust the underlying URL + score + published_date.
 - **Operational note for the connector:** Tavily is back online after a 3-day outage streak. The pull 8 / pull 9 / pull 10 advice to check `TAVILY_API_KEY`, Tavily status, and rate-limit posture no longer applies — the lane is functional again. No connector-side configuration change is required.
 - **Coverage:** fetched `2026-08-03T18:08:50.866Z`; 10 queries; raw `~/.openwiki/connectors/web-search/raw/2026-08-03T18-07-31-803Z/web-search-results.json`; instance `web-search-1`.
 queries; raw `~/.openwiki/connectors/web-search/raw/2026-08-03T18-07-31-803Z/web-search-results.json`; instance `web-search-1`.
 ion commitment. No new commitment; existing commitment Notes are extended.
  3. **CelVivo ClinoStar 2 / Thailand Lab 2026** — independent confirmation from an Indian distributor event page on the existing `celvivo-clinostar-2-nams-demo-2026` verification commitment. No new commitment; existing commitment Notes are extended.
 - **Workflow tooling refreshes:** `agent-memory-architecture` Last seen → 2026-08-03 (akitaonrails/ai-memory research doc added). `hermes-agent-v0-19-quicksilver` and `MiniMax-m3` evidence columns refreshed with same-week artifacts (Last seen unchanged at 2026-08-03 from the HN pull).
 - **Tavily answer-text quality:** the 3Brain answer is now correct (first time in 11 pulls); the Cellink Lumen X answer is substantive; the Hermes/M3 answer is partially fabricated ("release date of June 1, 2026") — treat as untrusted. Connector-side quality flag for future pulls: continue to treat Tavily answer text as untrusted; trust the underlying URL + score + published_date.
 - **Operational note for the connector:** Tavily is back online after a 3-day outage streak. The pull 8 / pull 9 / pull 10 advice to check `TAVILY_API_KEY`, Tavily status, and rate-limit posture no longer applies — the lane is functional again. No connector-side configuration change is required.
 - **Coverage:** fetched `2026-08-03T18:08:50.866Z`; 10 queries; raw `~/.openwiki/connectors/web-search/raw/2026-08-03T18-07-31-803Z/web-search-results.json`; instance `web-search-1`.
 queries; raw `~/.openwiki/connectors/web-search/raw/2026-08-03T18-07-31-803Z/web-search-results.json`; instance `web-search-1`.
 .
 h-1`.
 penwiki/connectors/web-search/raw/2026-08-03T18-07-31-803Z/web-search-results.json`; instance `web-search-1`.
 h-1`.
 nwiki/connectors/web-search/raw/2026-08-03T18-07-31-803Z/web-search-results.json`; instance `web-search-1`.
 h-1`.
@@ -3,7 +3,7 @@
 > 数据源: Wiki.js (http://10.10.10.254:3000/graphql) Biokingdom 实例
 > 用途: MiniMax code / Hermes 跨 agent 检索 "Robin 在 Wiki.js 发布了什么"
 > 更新: 自动同步计数 + 手动维护目录
-> 上次同步: **2026-08-10T18:30:02Z** · GraphQL sample (5 orderBy union): **83 unique pages** · ID range 22..1704 · 分布 en=5, zh=78
+> 上次同步: **2026-08-21T18:30:02Z** · GraphQL sample (5 orderBy union): **83 unique pages** · ID range 22..1704 · 分布 en=5, zh=78
 ## Wiki.js 概况
@@ -61,6 +61,8 @@ The state diagram shows the canonical CelVivo → 3Brain workflow: 3D suspension
 - **Bosnjakovic 2025 bioRxiv (PAH HepG2 3D spheroid, ClinoStar dynamic culture)** — 21-day maturation + 24h/96h BaP/BBF exposure; **4 metabolic markers (phenylalanine, TCA intermediates, GSH depletion, sphingolipid dysregulation) only appear in 3D, completely invisible in 2D**. Sales ammunition: "your 2D model is missing 100% of environmental toxicology early signals". Synthesis at [`/sources/literature-cel-bosnjakovic-2025-pah-deepread.md`](/sources/literature-cel-bosnjakovic-2025-pah-deepread.md).
 - **Miao 2025 Cell v2 (co-differentiation mesoderm + endoderm, vascularized lung/gut organoids, ClinoStar rotating culture)** — single 3D EB co-induction strategy yields **vHLPO with 7% ECs vs traditional HLPO 0%**, organ-specific endothelium + mesenchyme scRNA-seq validation, in-vivo functional integration with host circulation, FOXF1 mutation ACDMPV dual-pathology disease modeling. Product relevance: CelVivo ClinoStar rating 5 (co-differentiation depends on 3D EB self-organization in low-shear rotating culture — ClinoStar is the canonical hardware), HD-MEA rating 4, 3D bioprinting rating 3, patient-derived organoid drug screening rating 5. Synthesis at [`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`](/sources/literature-miao-2025-cell-vascularization-v2-deepread.md).
 - **Liu 2026 Nat Biomed Eng (shape-conformal porous framework for neural organoid e-phys, Rogers Lab)** — CelVivo ClinoStar rating 4 (organoid culture downstream of the shape-conformal framework; long-term maturation + functional readout is the canonical ClinoStar → HD-MEA workflow). Synthesis at [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md). See 3Brain evidence for the HD-MEA read side.
 - **Quintard 2024 Nat Commun (microfluidic platform integrating functional vascularized organoids-on-chip, 2026-08-16)** — CelVivo ClinoStar rating 3 (upstream workflow: BVO differentiation day 0-15 needs rotating-wall suspension culture; ClinoStar is the canonical hardware for this stage; the paper's day 15 → chip-on-board handoff is the canonical CelVivo → organ-on-chip workflow). Mimetas OrganoPlate rating 4 (direct Phaseguide-based vascularized / kidney / intestine organ-on-chip competitor — Robin's portfolio does not currently cover Mimetas but the platform represents a candidate cross-sell if Robin's customers ask "where do I run my CelVivo-matured organoids in a vascularized microenvironment?"). Emulate Organ-Chip rating 3 (Colon-Intestine-Liver platform companion). 10 通道并行微流控芯片 + hiPSC-BVO + 间充质球体 + 胰岛球体 + 肺类器官 跨类器官验证; 血管层级化 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管; 壁剪切 27-2000 s⁻¹ 完美匹配人体毛细血管生理范围 50-1900 s⁻¹. 4-commit LDR cycle 2026-08-16 (commits `0fc8db24` → `290e9635` → `24c713de` → `4073abf4` — last commit deleted the 3Brain reference per the SOP "硬门槛合规修正" cleanup rule because Quintard is organ-on-chip territory rather than 3Brain territory). Wiki IDs 1719/1720/1722, NocoDB Id 3297, DOI 10.1038/s41467-024-45710-4. Sales ammunition: "你的类器官前段培养到 day 15, 后段血管化怎么接? 我们的 CelVivo ClinoStar 提供 day 0-15 金标准旋转培养, 后接 Quintard 2024 微流控芯片做 30 天功能性血管化灌注". Customer entry: 药企临床前 (vascularized drug screening) + 微流控 organ-on-chip 平台集成商 (Mimetas / Emulate channel partners) + academic PI (vascular development / diabetes). Vault path: `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` (189 lines + 6 真图).
 - **Liang 2026 Sci Rep (mouse liver organoid 3-轨道 + fibrosis modeling, 2026-08-12)** — CelVivo ClinoStar rating 4 (P1-P10 长程扩增对应旋转培养 30+ 天无剪切; single DAPT only sustains P5, DAPT+Dex 协同才实现 P10 稳定成熟), CelVivo ClinoReactor rating 4 (单组织 3 轨道 [Hep/Cho/HSC] 分通道灌流; TGFβ 时间程序精确切换实现纤维化激活模型), CelVivo PhaseHolographic 成像 rating 3 (3D 球体直径/CV 实时 QC), 3Brain HD-MEA rating 3 (肝-神经互作延伸场景). 3 轨道 from 单份小鼠肝组织 (密度梯度离心 + 差速贴壁) → DAPT+Dex P1-P10 长程稳定成熟 (ALB / PAS / LDL / CYP 跨代保持) → TGFβ 5-7 天激活 qHSC → aHSC (Acta2/Col1a1 上调) → aHSC 共培养诱导 Hep-Orgs EMT (Snail/Twist/Vimentin ↑; ALB/CK8 ↓; Lgr5/EpCAM ↓; Ki67 ↓) = 体外肝纤维化模型. Wiki.js Id=1716, NocoDB Id=770, PMID 41857098. Page 946 9 项 SOP 重写版 + page 934 修齐 标杆 (4-commit LDR cycle 2026-08-12). **First deep-read whose `related:` field already names `[[MOC-类器官与3D培养]]`** on the day of publication — confirms MOC pattern in active use on real deep-reads. Vault path: `04-Literature/Deep-Reads/Liver/2026-08-12_Liang_2026_SciRep_liver_organoid_fibrosis_platform.md` (170 lines). Sales ammunition: "你的肝类器官只能短期培养? DAPT+Dex P1-P10 稳定成熟 + 单组织 3 轨道 + 14 天纤维化模型 — ClinoStar + ClinoReactor 一站搞定". Customer entry: 药企临床前 (抗纤维化药筛 14+ 天 3D 多细胞模型) + 临床肝活检中心 (1-2 mg 组织 → 3 周药敏 → ClinoReactor 6 通道一次测 6 药). Tracks in `/commitments.md` as `liang-2026-celvivo-clinostar-positioning`.
 - **Sales ammunition kit (CelVivo pricing + 8 Protocols + 5 app notes + 5 brand/whitepapers)** — Demo kit `10005-6` lists at €300 (Global Distributor Price, with special discount). 8 ClinoReactor Protocols cover prepare / media change / gardening / plate config / rotation-speed / alginate embed / VitroGel embed. 5 application notes cover HepG2/C3A liver, FTC-133 thyroid, NCI-H69V SCLC, TNBC, ClinoStar vs Orbital Shaker. Synthesis at [`/sources/sales-ammunition.md`](/sources/sales-ammunition.md).
 - **260528_CS vs OS app note (2026-07-17 deep read)** — ClinoStar vs Orbital Shaker shear-stress comparison for long-term 3D construct performance; ClinoStar has lower shear + long-term growth + better consistency. This is the **vs-competitor killer document** for "why not use an orbital shaker" customer questions.
 - **111_Planimetry app note (2026-07-17 deep read)** — Planimetry measurements of spheroids in ClinoReactor using FIJI (open-source). Standard answer for "how to quantify spheroids".
@@ -92,6 +94,7 @@ The state diagram shows the canonical CelVivo → 3Brain workflow: 3D suspension
 - **China CDE cell & gene therapy classification rules (2026-07-24)** — affects CelVivo-class deals in the Chinese pharma R&D / CDMO customer base. Tracks in [`/commitments.md`](/commitments.md) `china-cde-cell-gene-therapy-rules-2026`.
 - **China Order No. 818 (effective 2026-05-01)** — accelerated clinical-translation pathway for cell therapy and 3D bioprinting at qualified hospitals. Tracks as `china-order-no-818-clinical-translation`.
 - **Guo 2026 Front Cell Dev Biol organoid IRB / ethics systematic review (2026-08-16)** — CelVivo ClinoStar ⭐⭐⭐⭐ clinical-translation IRB compliance; **Robin 推广 ClinoStar 给三甲医院时, 可附带 Guo 2026 框架作为增值**. The paper structures the IRB review framework as 7 mandatory points (sample provenance + donor informed consent + data privacy & de-identification + co-culture agency + animal welfare 3R + cross-border regulation + long-term storage & termination) + a 5-jurisdiction cross-border table (China《人类遗传资源管理条例》+《涉及人的生命科学和医学研究伦理审查办法》2023 vs US HIPAA + Common Rule + NIH GDS vs EU GDPR + Clinical Trials Regulation 536/2014 vs Japan / Korea). 3-commit LDR cycle 2026-08-16 (`2e6f5989` → `00f824f2` → `a4fa5a32`). Wiki.js ID 1724, NocoDB Id 3298, DOI 10.3389/fcell.2026.1721946. **Robin translated the paper into a customer-facing IRB application checklist template** at `templates/类器官IRB申请清单.md` v1.0 (180 lines; 7 mandatory points checklist + 5 customer Q&A + China vs International flow table + 10 attachments + 7 citations). Tracks in `/commitments.md` as `guo-2026-organoid-irb-checklist-rollout` (Owner: me; fold IRB application checklist into CelVivo industrial-customers program + Robin customer-training core material; commit the template and add a synthesis page at `/sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md`). Vault path: `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` (170 lines + 3 真图).
 - **China CGT 2026-07 developments** — Merck–Bio-Techne $11.3B acquisition, CARsgen satri-cel solid-tumor CAR-T approval (positive); gene-editing trial death + regulatory backlash (negative). Tracks as `china-cgt-2026-july-developments`.
 ## Cross-cutting relationship
@@ -110,8 +113,12 @@ The state diagram shows the canonical CelVivo → 3Brain workflow: 3D suspension
 | What is Miao 2025's vascularized lung/gut organoid story? | [`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`](/sources/literature-miao-2025-cell-vascularization-v2-deepread.md) |
 | What is Liu 2026's shape-conformal neural organoid e-phys story? | [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md) |
 | What is Sharma 2026's vascularized retinal organoid RGC story? | [`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`](/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md) |
 | What is Liang 2026's liver organoid fibrosis platform story? | `04-Literature/Deep-Reads/Liver/2026-08-12_Liang_2026_SciRep_liver_organoid_fibrosis_platform.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
 | What is Quintard 2024's vascularized organoid chip story? | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
 | What is Guo 2026's organoid IRB / ethics story? | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
 | What is the IRB application checklist for organoid research? | `templates/类器官IRB申请清单.md` v1.0 (vault path; untracked) |
 | What distributors am I actually working with? | [`/sources/agents.md`](/sources/agents.md) |
 | Which Chinese dealers carry our brand? | [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) |
-| What regulatory shifts affect our Chinese pharma deals? | [`/commitments.md`](/commitments.md) China CDE / Order No. 818 / China CGT items |
+| What regulatory shifts affect our Chinese pharma deals? | [`/commitments.md`](/commitments.md) China CDE / Order No. 818 / Guo 2026 IRB / China CGT items |
 | What conferences is 3Brain at this season? | [`/commitments.md`](/commitments.md) `3brain-coreplate-2026-conference-positioning` |
 | What's the CelVivo → 3Brain joint workflow? | [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) (this page) Workflow chain section |
@@ -2,7 +2,8 @@
 type: "Reference"
 title: "Theme 5 · Robin's personal research (vendor deep reads + sales ammunition + CRM)"
 description: "Synthesis page for Robin's personal research portfolio — Obsidian vault + literature deep-read pipeline + sales ammunition + China distributor map + active CRM profiles + work-rhythm snapshots. Output routes into vendor themes 01 (organoid-equipment) and 02 (bioprinting)."
-tags: [theme, research, vault, deep-read, sales, crm, life-sciences]
+tags: [theme, research, vault, deep-read, sales, crm, life-sciences, 2026-08-21, 2026-08-20, 2026-08-19, 2026-08-18, 2026-08-17, 2026-08-15, 2026-08-13]
 timestamp: 2026-08-21T18:09:00Z
 ---
 # Theme 5 · Robin's personal research (vendor deep reads + sales ammunition + CRM)
@@ -22,7 +23,7 @@ This is the synthesis page for **Robin 个人研究项目** — the durable body
 ```mermaid
 erDiagram
-    VAULT["Obsidian vault (d97b39ed)"] ||--o{ DEEPREADS["Deep-read notes ~1,202"]
+    VAULT["Obsidian vault (a4fa5a32)"] ||--o{ DEEPREADS["Deep-read notes ~1,207"]
    VAULT ||--o{ TRAIN["Sales training (CelVivo赋能培训 v1-v9)"]
    VAULT ||--o{ SALES["Active sales pipeline (惠百生物 PO + 中间商)"]
    VAULT ||--o{ CRM["Distributor profiles (董慧群 + 待补)"]
@@ -31,6 +32,7 @@ erDiagram
    VAULT ||--o{ MEMORY["Daily + weekly reports (memory/ 147 .md)"]
    VAULT ||--o{ ITX["ITX 24h host build (untracked)"]
    VAULT ||--o{ MOC["MOCs (类器官与3D培养 first, +planned)"]
    VAULT ||--o{ TEMPLATES["Templates (类器官IRB申请清单 v1.0, untracked)"]
    DEEPREADS }o--|| VENDOR["Vendor mapping"]
    VENDOR ||--|{ CelVivo["CelVivo (ClinoStar / ClinoReactor)"]
@@ -49,18 +51,19 @@ The diagram shows Robin's research substrate: a single Obsidian vault with 8 buc
 ## Knowledge substrate: Obsidian vault
-Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08-10T18:06:19Z):
+Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08-21T18:09:00Z):
 | Field | Value |
 | --- | --- |
 | Repo path | `/home/ldw/workspace` |
 | Branch | `main` |
-| HEAD | `d97b39edb328b7e15d28de4a54a6d0bc2dd51274` (2026-08-10) |
+| HEAD | `a4fa5a323d6dcabeb9eccad49e636ee6ba5f87a6` (**unchanged** at the 2026-08-21T18:09Z fetch — **0 new vault commits** in the 2026-08-20T18:09Z → 2026-08-21T18:09Z 24-hour window; vault is silent for the **5th consecutive fetch** after the 2026-08-17T18:09Z + 2026-08-18T18:10Z + 2026-08-19T18:08Z + 2026-08-20T18:09Z silent windows; **5 calendar days stale** since the last vault HEAD bump on 2026-08-16; the 2026-08-16 Quintard 2024 Nat Commun 4-commit LDR cycle + Guo 2026 Front Cell Dev Biol 3-commit LDR cycle remain the most recent vault activity) |
-| Ahead of origin/main | 12 commits new since 2026-08-03 fetch (Fernandez Vallone 2026 + Microbioreactor 2026 + Liu 2026 v2-v11 + 4 经销商 hook 升级 + Wang 2024 Theranostics + **Phase A metadata batch + 2 sample runs**); plus 19 untracked files in working tree |
+| Ahead of origin/main | 20 commits new since 2026-08-03 fetch (unchanged from the 2026-08-17 + 2026-08-18 + 2026-08-19 + 2026-08-20 + 2026-08-21 fetches) |
 | Auth | local path only — no remote, no credentials |
-| Working-tree state | dirty (1 nested-submodule + 1 untracked dir + 19 untracked files including 8 new `02-Clients/Agents/区域-2026-0807.md`) |
+| Working-tree state | dirty (23 untracked files + 2 new untracked directories — `celvivo_commercial/1331651_20260630_131201.pdf` + `templates/类器官IRB申请清单.md` — both untracked; the `Review/zhou2023_computer_vision_microfluidics.md` first-entry-in-Review/-subfolder is still-uncommitted, carrying forward from the 2026-08-13 fetch, **10-day carry-forward** at the 2026-08-21T18:09Z fetch — **8 fetches silent** on the file) |
-| Raw manifest | `~/.openwiki/connectors/git-repo/raw/2026-08-10T18-06-18-966Z/manifest.json` |
+| Raw manifest | `~/.openwiki/connectors/git-repo/raw/2026-08-21T18-08-59-795Z/manifest.json` |
-| **Latest cluster (2026-08-10)** | **Phase A metadata batch** (`d97b39ed`) + **MOC 方案 1 样品** (`6b717aef`, first MOC `MOC-类器官与3D培养.md`) + **wang2024 方案 2 样品** (`3b929c2f`, 7 image alt descriptions) — frontmatter-hygiene + MOC-discipline sprint, no new external evidence |
+| **Latest cluster (2026-08-16, replacing the 2026-08-12 Liang 2026 cluster)** | **Quintard 2024 Nat Commun + Guo 2026 Front Cell Dev Biol 7-commit LDR cluster** (`0fc8db24` Quintard adds file 189 lines → `290e9635` -v2 → `24c713de` -v3 → `4073abf4` -v4 → `2e6f5989` Guo adds file 170 lines → `00f824f2` -v2 → `a4fa5a32` -v3) — **net-new external evidence** (DOI 10.1038/s41598-026-42990-2, PMID 41857098, mouse liver 3-轨道 Hep-Orgs + Cho-Orgs + HSC + DAPT+Dex P1-P10 长程成熟 + TGFβ 激活体外纤维化模型) |
 | **Latest uncommitted artifact (2026-08-13 → 2026-08-21, multi-file, unchanged at the 2026-08-21T18:09Z fetch)** | `04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md` (carry-forward untracked from 2026-08-13, now at **10-day carry-forward** at the 2026-08-21 fetch — file mtime `2026-08-11 16:31:54 +0800` so mtime-based carry-forward is 10 days; first-observation-date-based carry-forward is 8 days; **structural signal continuing to weaken** per `/sources/git-repo.md` Notable-entity entry — 8 consecutive fetches silent on the file; subfolder is more likely a one-off than a recurring pattern) + **2 new untracked directories added at the 2026-08-17 fetch**, still-uncommitted at the 2026-08-21 fetch (**5-day carry-forward** each — was 4-day at the 2026-08-20 fetch): `celvivo_commercial/1331651_20260630_131201.pdf` (6-30 quote PDF migrated into new folder) + `templates/类器官IRB申请清单.md` (180-line IRB application checklist derived from Guo 2026; Robin's first customer-facing template produced from a single deep-read — see the new Templates subtree below) |
 ### Vault navigation index (top-level folders)
@@ -89,7 +92,7 @@ Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08
 | Subfolder | .md count | Vendor / scope |
 | --- | ---: | --- |
-| `Organoid/` | 659 | broad organoid literature |
+| `Organoid/` | 661 (+2 from 2026-08-16 — Quintard 2024 Nat Commun microfluidic vascularized organoid chip + Guo 2026 Front Cell Dev Biol organoid ethics systematic review) | broad organoid literature |
 | `Celvivo/` | 142 | CelVivo vendor + CelVivo-adjacent papers |
 | `3Brain/` | 136 | 3Brain vendor + 3Brain-adjacent papers |
 | `Cellink/` | 129 | Cellink vendor + Cellink-adjacent papers |
@@ -98,15 +101,20 @@ Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08
 | `Brain/` | 11 | brain organoid focus |
 | `Brain-Tumor/` | 9 | brain tumor organoid |
 | `Cancer/` | 6 | cancer organoid |
-| `Liver/` | 6 | liver organoid / HepG2 |
+| `Liver/` | 7 | liver organoid / HepG2 (Liang 2026 4-commit LDR cycle 2026-08-12) |
 | `Other/` | 6 | uncategorised |
 | `RegenMed/` | 1 | Ronawk Bio-Block MSC 4-week (added 2026-07-28) |
 | `3Brain MEA/` | 3 | 3Brain HD-MEA papers |
 | `Cardiac/` | 2 | cardiac organoid |
 | `Kidney/` | 2 | kidney organoid |
 | `Retinal/` | 1 | retinal organoid |
 | `Microbioreactor/` | 1 | Rosero 2026 Front Bioeng Biotechnol (added 2026-08-07) |
 | `Cells/` | 1 | Fernandez Vallone 2026 Cells THSDC (added 2026-08-08) |
 | `Review/` | 1 | Zhou 2023 computer vision + microfluidics (added 2026-08-13, **untracked**, **9-day carry-forward** at 2026-08-20 fetch (was 8-day at 2026-08-19) — **7 fetches silent** — structural signal continuing to weaken) |
 | `Templates/` | 1 | `类器官IRB申请清单.md` v1.0 (2026-08-16, derived from Guo 2026 ethics deep-read, **untracked**; first customer-facing template produced from a single deep-read; **4-day carry-forward** at 2026-08-20 fetch — was 3-day at 2026-08-19) |
 | `CelVivo-commercial/` | 1 | `1331651_20260630_131201.pdf` (2026-06-30 quote PDF migrated into new folder 2026-08-17, **untracked**; **4-day carry-forward** at 2026-08-20 fetch — was 3-day at 2026-08-19) |
-Total ≈ 1,202 deep-read notes. The 4 vendor subfolders (Celvivo / 3Brain / Cellink / Organoid) cover the canonical product KB per the wiki goal focus areas.
+Total ≈ 1,206 deep-read notes on `main` + **1 untracked entry in the new `Review/` subfolder** (`zhou2023_computer_vision_microfluidics.md`, 2026-08-13 — first review-type subfolder; future-commit candidate) + **2 new untracked directories** (`templates/类器官IRB申请清单.md` + `celvivo_commercial/1331651_20260630_131201.pdf`, 2026-08-17). The 4 vendor subfolders (Celvivo / 3Brain / Cellink / Organoid) cover the canonical product KB per the wiki goal focus areas. The new `templates/` folder signals Robin may be formalizing customer-facing deliverables (checklists / templates / sales scripts) as a separate vault subtree — the IRB application checklist is the first such artifact.
 ## Literature deep-read (LDR) pipeline
@@ -175,13 +183,17 @@ From [`/sources/ldr-report-template.md`](/sources/ldr-report-template.md) (Robin
 | Sharma 2026 Cell Stem Cell (2026-08-08 flywheel-sync) | 3Brain + CelVivo adjacent | `/home/ldw/workspace/retinal_organoid_deep_read_2026-08-07.md` | [`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`](/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md) |
 | Miao 2025 Cell v2 (2026-08-08 flywheel-sync) | CelVivo (ClinoStar rating 5) | `/home/ldw/workspace/Miao2025_Cell_v2.md` | [`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`](/sources/literature-miao-2025-cell-vascularization-v2-deepread.md) |
 | Liu 2026 Nat Biomed Eng (2026-08-08 flywheel-sync) | 3Brain (HD-MEA rating 5) + Cellink (microlattice rating 5) | `/home/ldw/workspace/Liu2026_NBME_shape_conformal_organoid.md` | [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md) |
 | Quintard 2024 Nat Commun (2026-08-16 vault LDR cluster) | CelVivo (ClinoStar rating 3 upstream) + Mimetas OrganoPlate (rating 4 direct) + Emulate Organ-Chip (rating 3) | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` | (not yet synthesized to `/sources/`) |
 | Guo 2026 Front Cell Dev Biol (2026-08-16 vault LDR cluster) | CelVivo (ClinoStar rating 4 clinical-translation IRB) + Mimetas OrganoPlate (rating 4 co-culture ethics) + Emulate Organ-Chip (rating 3) | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` | (not yet synthesized to `/sources/`; derived customer-facing template at `templates/类器官IRB申请清单.md` v1.0) |
-## Recent 30-day research output (mtime 2026-06-16 → 2026-08-10)
+## Recent 30-day research output (mtime 2026-06-16 → 2026-08-12)
 From [`/sources/literature.md`](/sources/literature.md) last sync, broken out by vendor and date:
 | Date | DOI / slug | Vendor | Topic |
 | --- | --- | --- | --- |
 | 2026-08-16 | **Quintard 2024 Nat Commun + Guo 2026 Front Cell Dev Biol 7-commit LDR cluster** (commits `0fc8db24` + `290e9635` + `24c713de` + `4073abf4` Quintard + `2e6f5989` + `00f824f2` + `a4fa5a32` Guo) | **CelVivo adjacent + Mimetas OrganoPlate ⭐⭐⭐⭐ + Emulate Organ-Chip ⭐⭐⭐** (Quintard) / **CelVivo ClinoStar ⭐⭐⭐⭐ + Mimetas OrganoPlate ⭐⭐⭐⭐ + Emulate Organ-Chip ⭐⭐⭐** (Guo) | Quintard C et al. (2024) A microfluidic platform integrating functional vascularized organoids-on-chip (Nat Commun DOI 10.1038/s41467-024-45710-4, Wiki ID 1719/1720/1722, NocoDB Id 3297; 10 通道并行微流控 + hiPSC-BVO 30 天功能性灌注培养 + 跨类器官验证 [间充质球体 / BVO / 胰岛球体 / 肺类器官]; 血管层级化 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管, 壁剪切 27-2000 s⁻¹, 完美匹配人体毛细血管生理范围 50-1900 s⁻¹) + Guo Z & Zhang N (2026) Ethical review key considerations for organoid applications in biomedical research—a systematic review (Front Cell Dev Biol DOI 10.3389/fcell.2026.1721946, Wiki ID 1724, NocoDB Id 3298; 嘉兴市第一医院 + 嘉兴大学医学院视角; 类器官研究 IRB / 伦理审查 7 大强制要点系统综述 [样本来源/知情同意/数据隐私/共培养主体性/3R 动物福利/跨境监管/长期保存与终止使用] + 中国《人类遗传资源管理条例》+ 国际 ISSCR/GDPR/HIPAA 多国对照表). **Robin translated Guo 2026 into a customer-facing IRB application checklist template** (`templates/类器官IRB申请清单.md` v1.0 180 lines) — first customer-facing template produced from a single deep-read. |
 | 2026-08-12 | **Liang 2026 liver organoid fibrosis platform 4-commit LDR cycle** (commits `e542c977` + `8699a154` + `aacba7aa` + `297f106d`) | **CelVivo (ClinoStar rating 5 + ClinoReactor rating 5)** | Liang Y et al. (2026) A robust mouse liver organoid platform enables sustained multicellular maturation and fibrosis modeling from a single tissue sample (Sci Rep DOI 10.1038/s41598-026-42990-2, PMID 41857098; Wiki.js Id 1716, NocoDB Id 770; 3 轨道 Hep-Orgs + Cho-Orgs + HSC 同步分离; DAPT+Dex P1-P10 长程稳定成熟 [ALB/PAS/LDL/CYP 跨代保持]; TGFβ 激活 qHSC → aHSC [Acta2/Col1a1 上调]; aHSC 共培养诱导 Hep-Orgs EMT [Snail/Twist/Vimentin↑; ALB/CK8↓; Lgr5/EpCAM↓; Ki67↓] = 体外肝纤维化模型) — page 946 9 项 SOP 重写版 + page 934 修齐 标杆; 7/7 Ollama qwen2.5vl 视觉审核通过; SeaFile 7/7 公网 200 验真. First paper whose `related:` field already names `[[MOC-类器官与3D培养]]` (the 2026-08-10 first MOC) on the day of publication. |
 | 2026-08-10 | **Phase A metadata batch + first MOC** (commits `d97b39ed` + `6b717aef` + `3b929c2f`) | (process discipline) | 6 deep-reads received the 6-field frontmatter (doi/journal/year/volume/pages/authors/pmid); first MOC `MOC-类器官与3D培养.md` (95 lines, 沙牛《AI 时代的 Obsidian 公开课》课时 1 pattern) created at `04-Literature/Deep-Reads/MOCs/`; 7 image alt descriptions added on `wang2024-org-on-chip.md`. No new external evidence. |
 | 2026-08-09 | `10.7150/thno.90492` (Wang 2024) | (4 类共性硬件 — Organoid-on-Chip 综述) | Wang H et al. (2024) Human organoids-on-chips for biomedical research and applications (Theranostics 14(2):788-818, PMID 38169573; 7 图覆盖 7 大主题板块) — Wiki.js ID 1700 (v2 - grp:3 ghost page 累加) |
 | 2026-08-08 | `10.3390/cells15110963` (Fernandez Vallone 2026) | (NAMs adjacent, hiPSC brain organoid) | THSDC chemical evaluation platform using hiPSC brain organoids (Cells, v2 5 张真图 + 双 H1; Wiki.js Id 1698) |
@@ -208,15 +220,18 @@ From [`/sources/literature.md`](/sources/literature.md) last sync, broken out by
 By vendor (30-day mtime):
-| Vendor | Most recent | 2026-08-08 / 2026-08-10 additions |
+| Vendor | Most recent | 2026-08-08 / 2026-08-10 / 2026-08-12 / 2026-08-16 additions |
 | --- | --- | --- |
-| CelVivo | 2026-08-08 (Miao 2025 v2 — ClinoStar rating 5) | +Miao 2025 v2 (ClinoStar co-differentiation), +Sharma 2026 (ClinoStar rating 3 adjacent), +Liu 2026 (ClinoStar rating 4 adjacent) |
+| CelVivo | 2026-08-12 (Liang 2026 — ClinoStar rating 5 + ClinoReactor rating 5) | +Liang 2026 (P1-P10 长程成熟 + 单组织 3 轨道分通道灌流 + TGFβ 时间程序精确切换 — liver organoid fibrosis platform), +Miao 2025 v2 (ClinoStar co-differentiation), +Sharma 2026 (ClinoStar rating 3 adjacent), +Liu 2026 (ClinoStar rating 4 adjacent), +Quintard 2024 (CelVivo ClinoStar rating 3 — upstream workflow step: BVO day 0-15 needs rotating-wall suspension culture), +Guo 2026 (CelVivo ClinoStar rating 4 — clinical-translation IRB compliance for 三甲医院 客户) |
-| 3Brain | 2026-08-08 (Liu 2026 — HD-MEA rating 5) | +Liu 2026 (shape-conformal framework, next-gen HD-MEA), +Sharma 2026 (HD-MEA rating 4 adjacent), +Shin 2024 (Phase A frontmatter hygiene on existing note) |
+| 3Brain | 2026-08-08 (Liu 2026 — HD-MEA rating 5) | +Liu 2026 (shape-conformal framework, next-gen HD-MEA), +Sharma 2026 (HD-MEA rating 4 adjacent), +Shin 2024 (Phase A frontmatter hygiene on existing note), **−3Brain reference removed from Quintard 2024 -v4 (per commit `4073abf4` — "精读 Quintard 2024 -v4 (转发语标题/落款加粗/删3Brain)" was the explicit SOP rule "硬门槛合规修正" cleanup; Quintard is vendor-adjacent CelVivo/Mimetas/Emulate rather than 3Brain territory)** |
-| Cellink | 2026-07-27 (Tasevska 2025) | +Liu 2026 (microlattice fabrication rating 5 adjacent) |
+| Cellink | 2026-07-27 (Tasevska 2025) | +Liu 2026 (microlattice fabrication rating 5 adjacent), **+Quintard 2024 (microfluidic organ-on-chip adjacent, no direct Cellink rating — but the platform architecture is a candidate cross-sell with Cellink BIO X for vascularized scaffold fabrication)** |
 | Adjacent (no vendor) | 2026-08-08 (Sharma 2026 retinal vascularization) | +Sharma 2026 (retinal organoid application domain) |
 | (Process discipline) | 2026-08-10 (Phase A batch + first MOC) | +6 deep-reads received 6-field frontmatter; +first MOC `MOC-类器官与3D培养.md` created; +7 image alt descriptions on Wang 2024 — no new external evidence |
 | (Subfolder expansion, uncommitted) | 2026-08-13 (new `Review/` subfolder) | +1 untracked file `Review/zhou2023_computer_vision_microfluidics.md` (first review-type subfolder — review papers stream separately from original research) |
 | (Customer-facing template, uncommitted) | 2026-08-16 (new `templates/` subfolder + IRB application checklist v1.0) | +1 untracked file `templates/类器官IRB申请清单.md` 180 lines (Guo 2026 ethics deep-read → IRB checklist template; 7 mandatory points + 5 customer Q&A + China vs International flow + 10 attachments + 7 citations; Robin's first customer-facing template produced from a single deep-read; will route into CelVivo industrial-customers program once committed) |
 | (Commercial quote PDF, untracked) | 2026-08-17 (new `celvivo_commercial/` subfolder) | +1 untracked file `celvivo_commercial/1331651_20260630_131201.pdf` (6-30 quote PDF migrated into a new folder; companion to the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree) |
-The pipeline is **vendor-balanced** — CelVivo, 3Brain, Cellink each have a recent deep read, and the 2026-08-08 flywheel-sync adds **3 papers spanning all 3 primary vendors + the retinal organoid application domain** (Sharma), all 3 rated 4-5 on at least one vendor's product line. The 2026-08-10 cluster is **process discipline** (Phase A metadata batch + first MOC creation + Wang 2024 alt-description sample), not new external evidence — the 6 deep-reads already existed on `main`; the 3 commits only normalize their metadata and add a knowledge-graph index layer. The **first entry in the new NocoDB table `Robin_Picked_Papers`** is Liu 2026 (created 2026-08-08 per Robin instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage). The **first MOC** `MOC-类器官与3D培养.md` is the start of a Map-of-Content layer Robin appears to be building (the MOC's own `related:` already names `[[MOC-3Brain-HD-MEA]]` as the next planned MOC).
+The pipeline is **vendor-balanced** — CelVivo, 3Brain, Cellink each have a recent deep read, and the 2026-08-08 flywheel-sync adds **3 papers spanning all 3 primary vendors + the retinal organoid application domain** (Sharma), all 3 rated 4-5 on at least one vendor's product line. The 2026-08-10 cluster is **process discipline** (Phase A metadata batch + first MOC creation + Wang 2024 alt-description sample), not new external evidence — the 6 deep-reads already existed on `main`; the 3 commits only normalize their metadata and add a knowledge-graph index layer. The 2026-08-12 cluster adds **net-new external evidence**: Liang 2026 Sci Rep liver organoid fibrosis platform (4-commit LDR cycle on a single paper, CelVivo ClinoStar ⭐⭐⭐⭐ + ClinoReactor ⭐⭐⭐⭐); this is the **first paper on `main` whose `related:` field already names `[[MOC-类器官与3D培养]]` on the day of publication**, confirming the MOC pattern is in active use on real deep-reads (vs the prior 2026-08-10 "MOC `related:` lists future MOCs" framing which was only prospective). The **first entry in the new NocoDB table `Robin_Picked_Papers`** is Liu 2026 (created 2026-08-08 per Robin instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage). The **first MOC** `MOC-类器官与3D培养.md` is the start of a Map-of-Content layer Robin appears to be building (the MOC's own `related:` already names `[[MOC-3Brain-HD-MEA]]` as the next planned MOC). The 2026-08-13 cluster (no vault commits, 1 new untracked file) **adds a new `Review/` subfolder to the deep-read tree** — Robin appears to be expanding the folder taxonomy to separate review-type papers from original-research papers; whether this is a one-off subfolder or the start of a recurring folder pattern is a watchlist item for the next git-repo fetch. **The 2026-08-16 cluster (Quintard 2024 + Guo 2026) is the largest single-window vault delta since the 2026-07-28 / 2026-07-29 cluster** — 7 new vault commits spanning 2 new paper deep-reads, 2 new untracked working-tree directories, and 1 customer-facing sales-ammunition template derived from a single deep-read. The Quintard 2024 microfluidic / organ-on-chip platform (CelVivo ClinoStar upstream + Mimetas OrganoPlate direct competitor + Emulate Organ-Chip) extends Robin's vendor mapping into the organ-on-chip product lane that his portfolio doesn't currently cover; the Guo 2026 organoid ethics systematic review (7 mandatory points + 5 jurisdiction comparison) introduces the IRB / ethics domain to Robin's deep-read set and spawned `templates/类器官IRB申请清单.md` (180 lines, Robin's first customer-facing template) as the canonical "Robin 培训客户 IRB 申请" core material. The new `templates/` + `celvivo_commercial/` directories appear alongside the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree — Robin may be formalizing customer-facing deliverables (checklists / templates / sales scripts) as a separate vault subtree. The `Review/zhou2023_computer_vision_microfluidics.md` carry-forward untracked file is still-uncommitted at this fetch (now 4 days past the 2026-08-13 first observation); the watchlist trigger is if it remains uncommitted at the next fetch.
 ## Sales ammunition pipeline
@@ -230,6 +245,8 @@ Robin maintains a working sales library that consumes LDR output and routes into
 Cross-link to the canonical synthesis: [`/sources/sales-ammunition.md`](/sources/sales-ammunition.md).
 **2026-08-16 addition — `templates/类器官IRB申请清单.md` v1.0** (180 lines, Robin 8-16 实战沉淀, **untracked**; derived from Guo 2026 Front Cell Dev Biol IRB / ethics systematic review — Wiki.js ID 1724, NocoDB Id 3298). The IRB application checklist is **Robin 第一份 customer-facing template produced from a single deep-read** and consists of: (a) **7 强制要点** [样本来源合法性 + 捐赠者知情同意 + 数据隐私与去标识化 + 共培养产物主体性评估 + 动物福利 3R + 跨境监管合规 + 长期保存与终止使用]; (b) **5 customer Q&A** [类器官研究是否要 IRB 申请 / 类器官共培养产品怎么申请 IRB / 类器官跨境研究怎么报 / 3R 原则怎么写 / 类器官 + 免疫细胞共培养 = CAR-T 体外培养, 算不算新生物体]; (c) **China vs International flow comparison table** [中国 2023 新规 vs 美国 Common Rule vs 欧盟 GDPR]; (d) **10 申请附件清单** [IRB 申请表 + 知情同意书 + 研究方案 + DMP + 样本采集机构 IRB 批件 + ...]; (e) **7 引用** [Guo 2026 + ISSCR 2021 + OHRP 2016 + GDPR + 中国 2023 + 中国 2019 + Cambridge 2020]. **Vendor relevance**: CelVivo ClinoStar ⭐⭐⭐⭐ (the 7 mandatory points directly apply to ClinoStar customer IRB submissions; **Robin 推广 ClinoStar 给三甲医院时, 可附带本框架作为增值**). Tracks as `/commitments.md` `guo-2026-organoid-irb-checklist-rollout` (Owner: me; fold IRB application checklist into CelVivo industrial-customers program + Robin customer-training core material; commit `templates/类器官IRB申请清单.md` and add a synthesis page at `/sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md`).
 ## Sales training cluster (working-tree additions)
 Per `/sources/git-repo.md` §"Notable entities", `06-Sales/Content/Training-Materials/` contains the following working-tree additions not yet on `main`:
@@ -300,6 +317,8 @@ A dedicated subfolder under `05-Documents/Products/Celvivo/Industrial-Customers/
 This is a self-contained CelVivo China commercial effort. The latest mtime census (2026-07-16 snapshot) shows `CelVivo_中国工业客户开发研究报告_20260626_v2.md` as the most-recent file (18 KB, 06-26 11:52). Documented at [`/sources/git-repo.md`](/sources/git-repo.md) §Notable entities.
 **2026-08-17 working-tree addition — `celvivo_commercial/1331651_20260630_131201.pdf`** (56 KB, 2026-06-30 quote PDF migrated into a new folder; **untracked**) — companion to the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree. The new folder name signals Robin may be consolidating "Celvivo commercial" documents into a separate vault subtree rather than continuing to nest them under `05-Documents/Products/Celvivo/Industrial-Customers/` (which is the prior convention). If the convention holds, future CelVivo commercial PDFs / quotes / pricing tables will land in `celvivo_commercial/` instead of `05-Documents/Products/Celvivo/Industrial-Customers/`; if it doesn't hold, it's a one-off folder for the 6-30 quote. Watchlist trigger: if a second PDF or commercial doc lands in `celvivo_commercial/` by the next git-repo fetch, the convention change is real; if it stays single-entry, it's a one-off.
 ## Work-rhythm snapshot (2026-07-16)
 From [`/sources/vault-mtime-snapshot-2026-07-16.md`](/sources/vault-mtime-snapshot-2026-07-16.md) (last full mtime census):
@@ -392,3 +411,7 @@ These are source-anchored but not vendor-anchored — they live here for traceab
 | How does the local-LLM fleet host this evidence? | [`/themes/04-local-llm.md`](/themes/04-local-llm.md) |
 | Where does CelVivo + 3Brain output land? | [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) |
 | Where does Cellink output land? | [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md) |
 | What does Quintard 2024 say about vascularized organoid chips? | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
 | What does Guo 2026 say about organoid IRB ethics? | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
 | What's the IRB application checklist for organoid research? | `templates/类器官IRB申请清单.md` v1.0 (vault path; untracked) ||th; deep-read synthesis not yet split out to `/sources/`) |
 | What's the IRB application checklist for organoid research? | `templates/类器官IRB申请清单.md` v1.0 (vault path; untracked) ||
Author	SHA1	Message	Date
OpenWiki Bot	43d45483b5	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-22)	2026-08-22 02:30:02 +08:00
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OpenWiki Bot	bd30339182	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-20)	2026-08-20 02:30:02 +08:00
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OpenWiki Bot	dcb53a2873	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-19)	2026-08-19 02:30:02 +08:00
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OpenWiki Bot	be49285533	chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-17)	2026-08-17 02:30:02 +08:00
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Robin	b64ae41f3f	lit: PMID 41536916 Bioactive Materials AIVOs 综述 (Wiki.js 1711)	2026-08-11 15:18:38 +08:00
Robin	523ee7f540	lit: PMID 41686639 Cell Reports TNBC DEO + ROCK (Wiki.js 1710)	2026-08-11 13:40:38 +08:00
Robin	9be4f55435	lit: PMID 41909700 Front Immunol 2026 类器官-小胶质细胞综述 (Wiki.js 1709)	2026-08-11 13:28:52 +08:00
Robin	cc69eceb51	lit: PMID 42041571 v4 - 按 literature-deep-read-research 9 项强制格式	2026-08-11 12:35:37 +08:00
Robin	b4bc8d9081	lit: PMID 42041571 修正 - 真实PDF + 10张真图链接	2026-08-11 12:29:29 +08:00
Robin	12480ab166	lit: 修正 wiki_url 到真实内网地址	2026-08-11 12:14:12 +08:00