chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-22)

chore: daily update 2026-08-22
chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-21)
2026-08-22 02:30:02 +08:00 · 2026-08-22 02:17:39 +08:00 · 2026-08-21 02:30:02 +08:00 · 2026-08-21 02:27:31 +08:00 · 2026-08-20 02:30:02 +08:00 · 2026-08-20 02:15:52 +08:00
18 changed files with 1120 additions and 196 deletions
@@ -1,5 +1,5 @@
 {
-  "updatedAt": "2026-08-15T18:15:44.470Z",
+  "updatedAt": "2026-08-21T18:16:08.658Z",
  "command": "update",
  "model": "MiniMax-M3",
  "status": "complete",
@@ -2,7 +2,7 @@
 type: "Reference"
 title: "Commitments"
 description: "Active work tasks, follow-ups, approvals, and scheduled items extracted from sources (web-search, git-repo, literature flywheel-sync, etc.). Personal errands live in /personal-logistics.md instead."
-tags: [commitments, work, follow-ups, distributors-2026-08-07-refresh, dong-huiqun-ji-nan-chengquan-link, liang-2026-celvivo-clinostar-positioning]
+tags: [commitments, work, follow-ups, distributors-2026-08-07-refresh, dong-huiqun-ji-nan-chengquan-link, liang-2026-celvivo-clinostar-positioning, guo-2026-organoid-irb-checklist-rollout]
 ---
 # Commitments
@@ -116,6 +116,13 @@ Concrete work tasks, follow-ups, approvals, and scheduled items extracted from G
 - Status: open
 - Notes: 8-07 baseline differs from 7-24 baseline in: (a) total 261 → 259 (华北 74 → 72); (b) 济南成全生物科技有限公司 (曹沛起) cross-region registration (华北 + 山东); (c) new `_known_associations.md` index maps CelVivo → 济南成全 / FemtoBiomed → 9X Bio → TriArm / 3Brain + Cellink → 0. Cross-reference: [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) has been updated to the 8-07 baseline + new associations table; [`/sources/agents.md`](/sources/agents.md) still needs the 董慧群 → 济南成全 link; [`/commitments.md`](/commitments.md) has follow-up for 成都百乐 vs 成都立德赛 decision (open-question `chengdu-baile-vs-lidesai-for-ou-xianhong`). End-customer coverage for 3Brain / Cellink / FemtoBiomed still 0 in the 259 baseline — see open-question `distributors-3brain-cellink-zero-coverage`.
 ### guo-2026-organoid-irb-checklist-rollout: commit IRB application checklist template + add Guo 2026 deep-read synthesis page + fold into CelVivo industrial-customers program
 - Owner: me
 - Source: git-repo-1 2026-08-17 — vault commit cluster `2e6f5989` → `00f824f2` → `a4fa5a32` (Guo Z & Zhang N 2026 Front Cell Dev Biol organoid IRB / ethics systematic review, Wiki.js ID 1724, NocoDB Id 3298, DOI 10.3389/fcell.2026.1721946) + new untracked `templates/类器官IRB申请清单.md` v1.0 (180 lines, Robin 8-16 实战沉淀, derived from the Guo 2026 paper)
 - Due: unscheduled
 - Status: open
 - Notes: **First customer-facing template produced from a single deep-read** in Robin's vault — the IRB application checklist is the canonical "Robin 培训客户 IRB 申请" core material for class A tertiary hospitals running organoid IRB submissions. The 7 mandatory points + 5 customer Q&A + China vs International flow table + 10 attachments + 7 citations map directly to the CelVivo ClinoStar clinical-translation sales narrative (Guo 2026 lists CelVivo ClinoStar ⭐⭐⭐⭐ for IRB compliance ammunition). **Three follow-ups needed**: (a) **commit** `templates/类器官IRB申请清单.md` to `main` (currently untracked); (b) add a wiki-side deep-read synthesis page at `/sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md` mirroring the pattern at `/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`; (c) fold the IRB checklist into the existing `05-Documents/Products/Celvivo/Industrial-Customers/` CelVivo commercial docs subtree (or, if the `templates/` folder convention holds, fold it into the new `templates/` vault subtree instead — see Robin decision). Companion commitment to fold into Chinese customer IRB conversations: the checklist covers China《人类遗传资源管理条例》+ 《涉及人的生命科学和医学研究伦理审查办法》2023 — directly applicable to the next Class A tertiary hospital Robin visits for CelVivo or 3Brain training.
 <!--
 Structure for new entries:
@@ -14,5 +14,6 @@ okf_version: "0.1"
 # Directories
 - [large_tool_results](large_tool_results/)
 - [sources](sources/)
 - [themes](themes/)
@@ -2,7 +2,8 @@
 type: "Reference"
 title: "Sources"
 description: "Per-connector evidence indexes and ingestion coverage for the local knowledge wiki; durable synthesis lives on canonical pages."
-tags: [sources, connectors, evidence, ingestion]
+tags: [sources, connectors, evidence, ingestion, 2026-08-21]
 timestamp: 2026-08-21T18:35:00Z
 ---
 # Sources
@@ -13,9 +14,9 @@ Per-connector evidence indexes. Each connector gets its own page (for example `g
 | Connector | Page | Status |
 | --- | --- | --- |
-| Hacker News (`hackernews-1`, LLM-agent topics) | [/sources/hackernews.md](/sources/hackernews.md) | active |
+| Hacker News (`hackernews-1`, LLM-agent topics) | [/sources/hackernews.md](/sources/hackernews.md) | active (last 2026-08-21 18:00 UTC — tenth pull since 2026-08-07 with an empty / noise-only Algolia lane on vendor queries, all six Algolia queries (`organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents`) returning fully-zero hits — a stricter all-zero Algolia lane than the 2026-08-20 noise-only lane, with no application-domain thematic hits; the strongest named-stack-adjacent item is `49386163` "DeepSeek-v4-flash-vision-exp" 379 pts top+best (DeepSeek vision capability extension — DeepSeek V4 Flash is the canonical DeepSeek-M3 comparison benchmark cited on the `MiniMax-m3` row via benchlm.ai 2026-08-01, V4 vision is a V4-Flash capability milestone that expands into the same multimodal territory MiniMax-M3 occupies per the MyClaw.ai 2026-07-29 confirmation), with three secondary adjacents flagged for traceability: `49390739` Show HN Proliferate 11 pts (self-hostable open-source "Codex for any coding agent" — **Codex CLI is on Robin's named stack** but Proliferate is not, so adjacent-not-promoted per scope), `49378957` "The August 17 outage" 617 pts best / 722 cmts (GitHub blog post-mortem on the August 17 incident affecting Actions + Packages + Pages + Codespaces + API + webhooks; off-scope per scope but the highest-engagement infrastructure post-mortem of the pull), `49390463` "Building an (almost) fully self-hosted, sandboxed, agentic software factory" 16 pts top (4th entry in the 5-day self-hosted-agentic-substrate cluster after DeepSeek Harness 2026-08-13 + machine0 2026-08-18 + OneCLI 2026-08-19; cluster is now a recurring-signal watchlist candidate)) |
-| Git repo (`git-repo-1`, Obsidian vault + OpenWiki wiki) | [/sources/git-repo.md](/sources/git-repo.md) | active (last 2026-08-15 18:07 UTC) |
+| Git repo (`git-repo-1`, Obsidian vault + OpenWiki wiki) | [/sources/git-repo.md](/sources/git-repo.md) | active (last 2026-08-21 18:09 UTC — 0 new vault commits since 2026-08-20T18:09Z fetch (vault silent for the 5th consecutive fetch, **5 calendar days stale** since the 2026-08-16 Quintard + Guo cluster); 2 new automated wiki commits since 2026-08-20T18:09Z fetch (`b6dc337` daily update 2026-08-21 + `f6c2576` sources-sync 2026-08-21, the seventh consecutive sources-sync re-applying the 2026-08-15 count-data wipe pattern)) |
-| Web Search (`web-search-1`, Tavily) | [/sources/web-search.md](/sources/web-search.md) | active (latest pull 2026-08-03; 2026-08-08, 2026-08-10, 2026-08-12, and 2026-08-15 update attempts skipped — connector not enabled, `TAVILY_API_KEY` missing) |
+| Web Search (`web-search-1`, Tavily) | [/sources/web-search.md](/sources/web-search.md) | active (latest pull 2026-08-03; 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, 2026-08-17, 2026-08-18, 2026-08-19, and 2026-08-20 update attempts skipped — connector not enabled, `TAVILY_API_KEY` missing) |
 Additional connectors appear here automatically once they are authenticated and ingested at least once.
@@ -27,9 +28,9 @@ Additional connectors appear here automatically once they are authenticated and
 | Slack | not configured | `openwiki auth slack` | Needs `search:read` for definitive self-message search; otherwise falls back to recent conversations. |
 | Notion | not configured | Notion MCP credentials | Discovery via `openwiki_list_mcp_tools`; do not guess tool names. |
 | X / Twitter | not configured | `OPENWIKI_X_ACCESS_TOKEN` via `openwiki auth x` | Streams: `home_timeline`, `user_posts`, `mentions`, `bookmarks`, `list_posts`. |
-| Web Search | **active** (`web-search-1`) | `TAVILY_API_KEY` (currently empty) | Tavily via LangChain; reads configured queries. Latest successful pull 2026-08-03 18:08 UTC; the 2026-08-08, 2026-08-10, 2026-08-12, and 2026-08-15 update attempts were skipped because the connector was not enabled in the runtime registry. Evidence at [/sources/web-search.md](/sources/web-search.md). |
+| Web Search | **active** (`web-search-1`) | `TAVILY_API_KEY` (currently empty) | Tavily via LangChain; reads configured queries. Latest successful pull 2026-08-03 18:08 UTC; the 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, 2026-08-17, 2026-08-18, 2026-08-19, 2026-08-20, and 2026-08-21 update attempts were skipped because the connector was not enabled in the runtime registry (ninth consecutive skip on the same code path; nightly searxng-fallback slot for 2026-08-20 is also empty on disk). Evidence at [/sources/web-search.md](/sources/web-search.md). |
-| Hacker News | **active** (`hackernews-1`) | _(public, no auth)_ | Public feeds (`top`, `new`, `best`) + Algolia HN search queries. Source-specific query set: `organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents` (LLM-agent topics per the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories"). Last successful pull 2026-08-10 18:00 UTC — fourth consecutive "no promotable hits" pull under the 6-query set (empty-pulls-on-vendor-queries is normal cadence, not an outage). Evidence at [/sources/hackernews.md](/sources/hackernews.md). |
+| Hacker News | **active** (`hackernews-1`) | _(public, no auth)_ | Public feeds (`top`, `new`, `best`) + Algolia HN search queries. Source-specific query set: `organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents` (LLM-agent topics per the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories"). Last successful pull 2026-08-21 18:00 UTC — **tenth pull since 2026-08-07 with an empty / noise-only Algolia lane on vendor queries** (after the 2026-08-08 03:15 + 2026-08-08 18:00 + 2026-08-13 + 2026-08-15 + 2026-08-16 + 2026-08-18 + 2026-08-19 fully-zero pulls + the 2026-08-10 + 2026-08-12 + 2026-08-17 + 2026-08-20 noise-only pulls where vendor queries returned substring-fragment noise; the **2026-08-21 pull returns to fully-zero across all four vendor queries + both workflow queries — a stricter "all-zero Algolia lane" than the 2026-08-20 noise-only lane**, with no application-domain thematic hits to soften the absence; empty-pulls-on-vendor-queries is normal cadence, not an outage). The strongest named-stack-adjacent item of the pull is `49386163` "DeepSeek-v4-flash-vision-exp" 379 pts top+best (DeepSeek vision capability extension; DeepSeek V4 Flash is the canonical DeepSeek-M3 comparison benchmark cited on the `MiniMax-m3` row via benchlm.ai 2026-08-01 + the unsloth `unsloth/DeepSeek-V4-Flash-GGUF` quantized local-LLM run path; V4 vision is a V4-Flash capability milestone that expands into the same multimodal territory MiniMax-M3 occupies per the MyClaw.ai 2026-07-29 confirmation); three secondary adjacents flagged for traceability: `49390739` Show HN Proliferate 11 pts (self-hostable "Codex for any coding agent" — Codex CLI is on Robin's named stack so this is the strongest named-stack direct cross-walk of the pull by name, but Proliferate is not on the named stack and 11-pt engagement is below the 21-pt OneCLI / 19-pt machine0 / 46-pt MCP Memory / 100-pt vendor release bar; adjacent-not-promoted per scope), `49378957` "The August 17 outage" 617 pts best / 722 cmts (GitHub post-mortem; off-scope per scope but the highest-engagement infrastructure post-mortem of the pull), `49390463` "Building an (almost) fully self-hosted, sandboxed, agentic software factory" 16 pts top (4th entry in the 5-day self-hosted-agentic-substrate cluster after DeepSeek Harness 2026-08-13 + machine0 2026-08-18 + OneCLI 2026-08-19 — cluster is now a recurring-signal watchlist candidate). The 2026-08-20 pull (prior) produced the `class-organoid-3d-bioprinting` theme-row Last-seen refresh 2026-08-12 → 2026-08-20 via the recurrence criterion (the `49366519` Nature organoid-time-passage paper 18 pts + `49373812` Science Alert cross-walk — second neural-organoid HN signal in 9 pulls); that refresh carries forward unchanged into the 2026-08-21 pull (no organoid / 3D-bioprinting item on the 2026-08-21 pull). All four 2026-08-21 adjacents stay adjacent-not-promoted per scope discipline. Evidence at [/sources/hackernews.md](/sources/hackernews.md). |
-| Git repo | **active** (`git-repo-1`) | local repo path | Local Obsidian vault at `/home/ldw/workspace` + OpenWiki wiki at `/home/ldw/.openwiki/wiki` (two configured repos per `~/.openwiki/connectors/git-repo/config.json`). Writes compact manifest; repo itself is source of truth. Evidence at [/sources/git-repo.md](/sources/git-repo.md). Last updated 2026-08-15 18:07 UTC. |
+| Git repo | **active** (`git-repo-1`) | local repo path | Local Obsidian vault at `/home/ldw/workspace` + OpenWiki wiki at `/home/ldw/.openwiki/wiki` (two configured repos per `~/.openwiki/connectors/git-repo/config.json`). Writes compact manifest; repo itself is source of truth. Evidence at [/sources/git-repo.md](/sources/git-repo.md). Last updated 2026-08-21 18:09 UTC — **0 new vault commits in the 24-hour window** (vault silent for the 5th consecutive fetch; the 2026-08-16 Quintard 2024 + Guo 2026 cluster remains the most recent vault activity, **5 calendar days stale**); 2 new automated wiki commits since the 2026-08-20 fetch (`b6dc337` daily update 2026-08-21 + `f6c2576` sources-sync 2026-08-21, the **seventh** consecutive sources-sync re-applying the 2026-08-15 count-data wipe pattern after `997b648` 2026-08-16 + `be49285` 2026-08-17 + `1fc73ae` 2026-08-18 + `dcb53a2` 2026-08-19 + `bd30339` 2026-08-20 + now `f6c2576` 2026-08-21). |
 ## How new source pages get created
@@ -39,4 +40,4 @@ When a connector ingests for the first time, an update run will:
 2. Create `/sources/<connector>.md` with the ingestion manifest, freshness, and compact evidence notes.
 3. Route durable items into the canonical pages and add a row in `/themes.md` if a recurring signal emerges.
-Until then, the new connector only has a row in the active connectors table above and no evidence page of its own..
+Until then, the new connector only has a row in the active connectors table above and no evidence page of its own..its own..
@@ -1,10 +1,10 @@
 ---
 type: "Reference"
 title: "Git repo — evidence index (Obsidian vault, Robin)"
-description: "Compact manifest of Robin's Obsidian vault + the local OpenWiki wiki, ingested through the local git-repo connector. Two configured repos: obsidian-vault at /home/ldw/workspace (main branch, HEAD 297f106d, 2026-08-12, unchanged across the 2026-08-13 / 2026-08-15 fetches) and openwiki-wiki at /home/ldw/.openwiki/wiki (main branch, HEAD 2507925, 2026-08-15). This page is a navigation index — content ingestion (paper deep reads, sales scripts, customer files) happens via the Hermes skill and RAGFlow, not here."
+description: "Compact manifest of Robin's Obsidian vault + the local OpenWiki wiki, ingested through the local git-repo connector. Two configured repos: obsidian-vault at /home/ldw/workspace (main branch, HEAD a4fa5a32, 2026-08-16, **0 new vault commits in the 2026-08-20T18:09Z → 2026-08-21T18:09Z 24-hour window — vault is silent for the 5th consecutive fetch after the 2026-08-16 Quintard + Guo cluster, 5 calendar days stale**) and openwiki-wiki at /home/ldw/.openwiki/wiki (main branch, HEAD f6c2576, 2026-08-21, **2 new automated wiki commits in the 2026-08-20T18:09Z → 2026-08-21T18:09Z window: `b6dc337` daily update 2026-08-21 + `f6c2576` sources-sync 2026-08-21 — the seventh consecutive sources-sync re-applying the 2026-08-15 count-data wipe pattern**). This page is a navigation index — content ingestion (paper deep reads, sales scripts, customer files) happens via the Hermes skill and RAGFlow, not here."
 resource: "~/.openwiki/connectors/git-repo/config.json"
-tags: [git-repo, evidence, vault, openwiki-wiki, source, 2026-08-15, 2026-08-13]
+tags: [git-repo, evidence, vault, openwiki-wiki, source, 2026-08-21, 2026-08-20, 2026-08-19, 2026-08-18, 2026-08-17, 2026-08-15, 2026-08-13]
-timestamp: 2026-08-15T18:07:49Z
+timestamp: 2026-08-21T18:09:00Z
 ---
 # Git repo — evidence index (Obsidian vault + OpenWiki wiki)
@@ -22,53 +22,106 @@ help locate things in the vault, not summarize their content.
  `~/.openwiki/connectors/git-repo/config.json`)
 - **Configured repos:**
  - `obsidian-vault` → `/home/ldw/workspace` (Robin Obsidian vault, on
-    `main`, HEAD `297f106d2b137af3480261052ff080cbc48d5b48` as of
+    `main`, HEAD `a4fa5a323d6dcabeb9eccad49e636ee6ba5f87a6` as of
-    2026-08-12 — unchanged across the 2026-08-13 and 2026-08-15 fetches,
+    2026-08-16 +0800 — 7 new vault commits in the
-    0 new vault commits in either 24-hour window).
+    2026-08-15T18:07Z → 2026-08-17T18:09Z 48-hour window: the 2026-08-16
    **Quintard 2024 Nat Commun 4-commit LDR cycle** (`0fc8db24` adds
    file 189 lines → `290e9635` -v2 修图床/双 H1/落款 → `24c713de`
    -v3 Wiki.js 自带图床 6 张图 → `4073abf4` -v4 转发语标题/落款加粗/删
    3Brain) + the 2026-08-16 **Guo 2026 Front Cell Dev Biol 3-commit LDR
    cycle** (`2e6f5989` adds file 170 lines → `00f824f2` -v2 修图床 →
    `a4fa5a32` -v3 补 Fig 1) — the first time two new paper LDR cycles
    land within the same 48-hour window since the 2026-07-28 / 2026-07-29
    Parate / Lee / Hodge cluster. The 2026-08-12 Liang 2026 4-commit LDR
    cycle remains the prior baseline cluster).
  - `openwiki-wiki` → `/home/ldw/.openwiki/wiki` (the OpenWiki knowledge
-    base itself, on `main`, HEAD `2507925e27b83b4f9d2e6f3b9c939d081a90f9f2`
+    base itself, on `main`, HEAD `dcb53a2873d37b6396de682d658433c2ea85b376`
-    as of 2026-08-15T02:31 +0800 — 4 new wiki-side commits in the
+    as of 2026-08-19T +0800 — 8 new wiki-side commits across the
-    2026-08-14T18:08Z → 2026-08-15T18:07Z window: `021e929` daily
+    2026-08-15T18:07Z → 2026-08-19T18:08Z window: `151d22b` daily
-    update 2026-08-14 + `6258717` sources-sync 2026-08-14 + `173b58c`
+    update 2026-08-16 + `997b648` sources-sync 2026-08-16 + `5c70881`
-    daily update 2026-08-15 + `2507925` sources-sync 2026-08-15).
+    daily update 2026-08-17 + `be49285` sources-sync 2026-08-17 +
    `8127797` daily update 2026-08-18 + `1fc73ae` sources-sync
    2026-08-18 + `7e904ec` daily update 2026-08-19 + `dcb53a2`
    sources-sync 2026-08-19; the `5c70881` daily update also created
    the new `sources/openwiki-version-drift.md` auto-generated page;
    the 4 sources-syncs (`997b648` + `be49285` + `1fc73ae` + `dcb53a2`)
    all re-applied the `2507925` 2026-08-15 count-data wipe pattern).
 - **Auth:** local paths only — no remote, no credentials.
- **Latest fetch:** `2026-08-15T18:07:49Z` (raw manifest
+- **Latest fetch:** `2026-08-21T18:09:00Z` (raw manifest
-  `~/.openwiki/connectors/git-repo/raw/2026-08-15T18-07-49-711Z/manifest.json`).
+  `~/.openwiki/connectors/git-repo/raw/2026-08-21T18-08-59-795Z/manifest.json`).
 - **Source config:** `~/.openwiki/connectors/git-repo/config.json`
 - **State:** `~/.openwiki/connectors/git-repo/state.json` records
-  `latestIds` per repo; the 2026-08-15 fetch observed vault HEAD
+  `latestIds` per repo; the 2026-08-21T18:09Z fetch observed vault HEAD
-  unchanged at `297f106d` (no new vault commits in the 24-hour window —
+  unchanged at `a4fa5a32` (2026-08-16 — same as the 2026-08-17T18:09Z +
-  the 2026-08-12 Liang 2026 cluster of 4 commits is still the most
+  2026-08-18T18:10Z + 2026-08-19T18:08Z + 2026-08-20T18:09Z +
-  recent vault activity, and the 2026-08-13 cluster of 3 frontmatter-hygiene
+  2026-08-21T18:09Z fetches;
-  + MOC-discipline commits + the 2026-08-11 cluster of 4 PMID deep-read
+  **0 new vault commits in the 24-hour window — vault is silent for
-  commits are all already merged into `297f106d`) and bumped
+  the 5th consecutive fetch** after the 2026-08-16 Quintard + Guo
-  `openwiki-wiki` from `1737454` (2026-08-13) to `2507925` (2026-08-15,
+  cluster, **5 calendar days stale**), and observed `openwiki-wiki`
-  4 new commits — `021e929` + `6258717` + `173b58c` + `2507925`).
+  bumped from `bd30339` (2026-08-20T18:09Z fetch) to `f6c2576`
  (2 new automated wiki commits in the 24-hour window: `b6dc337` daily
  update 2026-08-21 + `f6c2576` sources-sync 2026-08-21 — the
  **seventh** consecutive sources-sync re-applying the 2026-08-15
  count-data wipe pattern after `997b648` 2026-08-16 + `be49285`
  2026-08-17 + `1fc73ae` 2026-08-18 + `dcb53a2` 2026-08-19 + `bd30339`
  2026-08-20 + now `f6c2576` 2026-08-21).
-## obsidian-vault — working-tree status (2026-08-15)
+## obsidian-vault — working-tree status (2026-08-21)
 - **Branch:** `main`
- **HEAD:** `297f106d2b137af3480261052ff080cbc48d5b48` (vault HEAD
+- **HEAD:** `a4fa5a323d6dcabeb9eccad49e636ee6ba5f87a6` (vault HEAD
-  **unchanged** across the 2026-08-13 and 2026-08-15 fetches — 0 new
+  **unchanged** at `a4fa5a32` across the 2026-08-21T18:09Z fetch —
-  commits in either 24-hour window; the 2026-08-12 Liang 2026 cluster of
+  **0 new commits** in the 2026-08-20T18:09Z → 2026-08-21T18:09Z
-  4 commits remains the most recent vault activity).
+  24-hour window; the vault is silent for the **5th consecutive
- **Ahead of origin/main:** 13 commits new since 2026-08-03 fetch (same
+  fetch** after the 2026-08-17T18:09Z + 2026-08-18T18:10Z +
-  count as the 2026-08-13 fetch — the 2026-08-12 Liang 2026 cluster of 4
+  2026-08-19T18:08Z + 2026-08-20T18:09Z silent windows. The 2026-08-16
-  commits is still the most recent vault activity).
+  Quintard 2024 Nat Commun 4-commit LDR cycle + Guo 2026 Front Cell
  Dev Biol 3-commit LDR cycle remain the most recent committed vault
  activity (vault HEAD last bumped on 2026-08-16, **5 calendar
  days before this fetch** — same state as the
  2026-08-17T18:09Z + 2026-08-18T18:10Z + 2026-08-19T18:08Z +
  2026-08-20T18:09Z fetches).
 - **mtime activity in window:** **0 new mtime changes** in the
  2026-08-20T18:09Z → 2026-08-21T18:09Z 24-hour window. The 2
  untracked dirs from the 2026-08-17T18:09Z fetch are unchanged:
  `celvivo_commercial/` last touched 2026-08-17 15:04 +0800 (= 07:04
  UTC, **before** the 24h window) + `templates/` last touched
  2026-08-16 10:27 +0800 (= 02:27 UTC, well before the window). The
  `Review/zhou2023_computer_vision_microfluidics.md` first-entry
  file is unchanged from the 2026-08-17T18:09Z fetch (mtime
  2026-08-11, **10-day carry-forward** in the untracked set at this
  fetch — was 9-day at the 2026-08-20T18:09Z fetch; the structural
  signal continues to weaken per the Notable-entity entry on the
  `Review/` subfolder).
 - **Ahead of origin/main:** 20 commits new since 2026-08-03 fetch (unchanged from the 2026-08-17T18:09Z + 2026-08-18T18:10Z + 2026-08-19T18:08Z + 2026-08-20T18:09Z fetches — vault is silent in the 2026-08-20T18:09Z → 2026-08-21T18:09Z window).
 - **Dirty:** yes — the untracked file set is **unchanged** from the
-  2026-08-13 fetch (no new untracked files appeared in the 2026-08-15
+  2026-08-17T18:09Z fetch (no new untracked files or directories
-  24-hour window). The set is: 8 × `02-Clients/Agents/区域-2026-0807.md`
+  appeared in the 2026-08-17T18:09Z → 2026-08-18T18:10Z 24-hour
-  distributor-rebuild files (per the 2026-08-07 Hermes hook 4 sweep) +
+  window, no new untracked files or directories appeared in the
-  the existing 15 working-folder files (Parfitt 2024 DJ1 LOF midbrain +
+  2026-08-18T18:10Z → 2026-08-19T18:08Z 24-hour window, no new
-  Liu2026 / Miao2025 v2 / Miao2025 vascularized / Microbioreactor 2026 /
+  untracked files or directories appeared in the 2026-08-19T18:08Z →
-  `__pycache__/literature_deepread_v6.cpython-312.pyc` / `dify精读进度-20260805.md`
+  2026-08-20T18:09Z 24-hour window, and no new untracked files or
-  / `literature_deepread_v6.py` / `obsidian-vault/04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md`
+  directories appeared in the 2026-08-20T18:09Z → 2026-08-21T18:09Z
  24-hour window either). The 25+ untracked entries from the
  2026-08-17T18:09Z fetch carry forward unchanged: 8 ×
  `02-Clients/Agents/区域-2026-0807.md` distributor-rebuild files
  (per the 2026-08-07 Hermes hook 4 sweep) + 14 working-folder files
  (Parfitt 2024 DJ1 LOF midbrain + Liu2026 / Miao2025 v2 /
  Miao2025 vascularized / Microbioreactor 2026 /
  `__pycache__/literature_deepread_v6.cpython-312.pyc` /
  `dify精读进度-20260805.md` / `literature_deepread_v6.py` /
  `obsidian-vault/04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md`
  / `obsidian-vault/rustdesk-selfhosted-2026-08-05.md` /
-  `retinal_organoid_deep_read_2026-08-07.md` / `文悦精读流水线.yml` + v2/v3/v4/v5-clean
+  `retinal_organoid_deep_read_2026-08-07.md` / `文悦精读流水线.yml` +
-  variants). The **`Review/zhou2023_computer_vision_microfluidics.md`
+  v2/v3/v4/v5-clean variants) + 2 new untracked working-tree
  directories from the 2026-08-17T18:09Z fetch (`celvivo_commercial/`
  + `templates/`). The **`Review/zhou2023_computer_vision_microfluidics.md`
  first entry in the new `Review/` subfolder** is still **untracked**
-  (Robin has not yet committed it) — the structural signal carried
+  (Robin has not yet committed it) — **10-day carry-forward** at this
-  forward from the 2026-08-13 fetch.
+  fetch (was 9-day at the 2026-08-20T18:09Z fetch); the structural
  signal continues to weaken per the Notable-entity entry on the
  `Review/` subfolder (the subfolder has been a single-entry watchlist
  since 2026-08-13, now **8 fetches silent**).
 - **Working-tree status (raw manifest, abbreviated):**
  | Status | Path |
@@ -77,6 +130,8 @@ help locate things in the vault, not summarize their content.
  | `M` (committed 2026-08-12, `8699a154`) | same Liang 2026 file — page 946 9 项 SOP 重写版 (105+/122- lines) |
  | `M` (committed 2026-08-12, `aacba7aa`) | same Liang 2026 file — frontmatter title 改中文 + 与正文 H1 一致 (1-line touch) |
  | `M` (committed 2026-08-12, `297f106d`) | same Liang 2026 file — 修齐 page 934 标杆 (H1 去括号/元数据用bold/📄PDF文件名, 5+/4- lines) |
  | `A` (committed 2026-08-16, `a4fa5a32`) | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` — **NEW external evidence** (Guo Z, Zhang N 2026 Front Cell Dev Biol DOI 10.3389/fcell.2026.1721946 — IRB / ethics systematic review; Wiki ID 1724, NocoDB Id 3298, 170 lines + 3 张真图; "与我们的产品" table lists CelVivo ClinoStar ⭐⭐⭐⭐ [临床转化类器官的伦理合规——7 大要点直接适用 IRB 申请] + Mimetas OrganoPlate ⭐⭐⭐⭐ [类器官 + 免疫细胞共培养伦理审查依据] + Emulate Organ-Chip ⭐⭐⭐; 3 commits `2e6f5989` → `00f824f2` → `a4fa5a32` = adds → -v2 修图床 → -v3 补 Fig 1) |
 | `A` (committed 2026-08-16, `0fc8db24`) | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` — **NEW external evidence** (Quintard C et al. 2024 Nat Commun DOI 10.1038/s41467-024-45710-4 — microfluidic platform for vascularized organoid chips; Wiki IDs 1719/1720/1722, NocoDB Id 3297; 4 commits `0fc8db24` → `290e9635` → `24c713de` → `4073abf4` = adds 189 lines → -v2 修图床/双 H1/落款 → -v3 Wiki.js 自带图床 6 张图 → -v4 转发语标题/落款加粗/删 3Brain; "与我们的产品" table lists Mimetas OrganoPlate ⭐⭐⭐⭐ [直接对标: Phaseguide 微流控技术用于血管化/肾/肠 organ-on-chip] + CelVivo ClinoStar ⭐⭐⭐ [类器官前段成熟期培养: BVO 在 hiPSC 分化到 day 15 需要悬浮旋转培养, ClinoStar 是该步骤的金标准; day 15 后才转入芯片, ClinoStar 是完整工作流的前置] + Emulate Organ-Chip ⭐⭐⭐) |
 | `M` (committed 2026-08-10) | `04-Literature/Deep-Reads/Organoid/2026-07-29_Organoids_disease_modeling_treatment_2026_review.md` (Phase A batch frontmatter — `volume` / `pages` / `authors` array; also touched by `6b717aef` for related back-link) |
  | `M` (committed 2026-08-10) | `CelVivo_精读报告_04_bioRxiv_PAH_Metabolomics.md` (Phase A batch frontmatter — `volume` / `pages` / `authors` array; also touched by `6b717aef`) |
  | `M` (committed 2026-08-10) | `obsidian-vault/04-Literature/Deep-Reads/3Brain/shin-2024-thalamocortical-organoids-22q11ds.md` (Phase A batch frontmatter; also touched by `6b717aef`) |
@@ -86,6 +141,8 @@ help locate things in the vault, not summarize their content.
  | `M` (committed 2026-08-10) | `04-Literature/Deep-Reads/wang2024-org-on-chip.md` (方案 2 样品 — 6 frontmatter fields + 7 alt descriptions; also touched by `6b717aef`) |
  | `A` (committed 2026-08-10) | `04-Literature/Deep-Reads/MOCs/MOC-类器官与3D培养.md` (方案 1 — **first MOC file**; 95 lines; 沙牛《AI 时代的 Obsidian 公开课》课时 1 pattern; `related:` already lists `[[MOC-3Brain-HD-MEA]]` as a forward link) |
  | `??` (untracked) | `02-Clients/Agents/全国经销商地图-2026-0807.md` + 7 区域 `*2026-0807.md` files (8-07 distributor baseline refresh — see below) |
  | `??` (untracked, **NEW 2026-08-17**) | `celvivo_commercial/1331651_20260630_131201.pdf` — **NEW** untracked directory; the 6-30 quote PDF Robin migrated into a new `celvivo_commercial/` folder; companion to the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree |
  | `??` (untracked, **NEW 2026-08-17**) | `templates/类器官IRB申请清单.md` — **NEW** untracked directory; the IRB application checklist derived from the Guo 2026 ethics-review deep-read (180 lines; 7 mandatory points [样本来源/知情同意/数据隐私/共培养主体性/3R 动物福利/跨境监管/长期保存与终止使用] + 5 customer Q&A + China vs International flow table + 10 attachments + 7 citations); Robin's **first customer-facing template** derived from a single deep-read — materializes the "Robin 业务定位: 类器官厂家给三甲医院 IRB 申请的标准模板 + Robin 客户培训材料核心" framing from the Guo 2026 deep-read |
  | `??` (untracked) | `04-Literature/Deep-Reads/Brain/2026-08-06_Parfitt_GM_et_al_NatCommun_2024_DJ1_LOF_midbrain_organoid_PD.md` |
  | `??` (untracked) | `Liu2026_NBME_shape_conformal_organoid.md` |
  | `??` (untracked) | `Miao2025_Cell_v2.md` |
@@ -111,6 +168,13 @@ help locate things in the vault, not summarize their content.
 | Date | Hash | Note |
 | --- | --- | --- |
 | 2026-08-16 | `a4fa5a32` | **literature: review 类 Guo 2026 -v3 补 Fig 1** — in-place update ID 1724, 3 张图全 |
 | 2026-08-16 | `00f824f2` | **literature: review 类 Guo 2026 -v2 修图床** — in-place update ID 1724, 加 2 张 Wiki.js 自带图 |
 | 2026-08-16 | `2e6f5989` | **literature: 精读 Guo 2026 Front Cell Dev Biol - 类器官伦理审查** (review 类, Wiki ID 1724, NocoDB Id 3298) — **NEW external evidence** (类器官研究 IRB / 伦理审查 7 大强制要点系统综述, 嘉兴市第一医院 + 嘉兴大学医学院视角) |
 | 2026-08-16 | `4073abf4` | **literature: 精读 Quintard 2024 -v4** — 转发语标题/落款加粗/删3Brain |
 | 2026-08-16 | `24c713de` | **literature: 精读 Quintard 2024 -v3 Wiki.js 自带图床** (ID 1722, 6 张图永久) |
 | 2026-08-16 | `290e9635` | **literature: 精读 Quintard 2024 -v2 修图床/双 H1/落款** (Wiki ID 1720) |
 | 2026-08-16 | `0fc8db24` | **literature: 精读 Quintard 2024 Nat Commun - 微流控血管化类器官芯片** (Wiki ID 1719, NocoDB Id 3297) — **NEW external evidence** (10 通道并行微流控 + hiPSC-BVO 30 天功能性灌注培养 + 跨类器官验证) |
 | 2026-08-12 | `297f106d` | **literature: 修齐 page 934 标杆** — H1 去括号 / 元数据用 bold / 📄PDF 文件名 (Liang 2026 v3) |
 | 2026-08-12 | `aacba7aa` | **literature: frontmatter title 改中文 + 与正文 H1 一致** (Liang 2026 v2) |
 | 2026-08-12 | `8699a154` | **literature: Liang 2026 Sci Rep liver organoid fibrosis - page 946 9 项 SOP 重写版** (Liang 2026 v2; 105+/122- lines; core-question / research-model / 6-finding 3-stage tables / 6 SeaFile Fig / "与我们的产品" 4-star / 4-paper refs / 转发语 / 完整落款) |
@@ -140,6 +204,60 @@ help locate things in the vault, not summarize their content.
 | 2026-07-28 | `2718e46d` | feat(literature): Parate 2020 SCRT — PEMF 增强 MSC 旁分泌功能促软骨再生 |
 | 2026-07-28 | `032de92f` | feat: 精读 Lee 2025 Front Vet Sci 犬脂肪源 MSC 3D 球体 |
 The **2026-08-16 cluster** is a **two-paper LDR cycle on the same day**
 covering both an **organ-on-chip microfluidic platform paper** and an
 **organoid ethical-review systematic-review paper**:
 - **Quintard C et al. (2024) Nat Commun DOI 10.1038/s41467-024-45710-4**
  — a microfluidic platform for vascularized organoids-on-chip. The
  paper establishes: (i) 10-channel parallel microfluidic chip (COC
  热压成型, U 型捕获位 300-800 µm 可调); (ii) fibrin + Matrigel hydrogel
  with Landau-Levich-Bretherton 效应 → 100% 捕获效率 in 10 sec per
  channel; (iii) hiPSC-derived blood vessel organoids (BVO, day 15)
  + GFP-HUVEC + 纤维细胞共培养 → 30 天功能性灌注培养; (iv) 壁剪切速率
  27-2000 s⁻¹, mean 134-531 s⁻¹ (与人体毛细血管生理范围 50-1900 s⁻¹
  完美匹配); (v) 层级化血管: 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管.
  The 4 commits are the same single file
  `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md`
  walked through Robin's standard LDR cycle: (a) **`0fc8db24`** adds
  the file (189 lines, single-pass entry); (b) **`290e9635`** rewrites
  to -v2 修图床/双 H1/落款; (c) **`24c713de`** adds -v3 Wiki.js 自带
  图床 6 张图 (永久); (d) **`4073abf4`** is the -v4 转发语标题/落款
  加粗 + 删 3Brain 工具名硬门槛合规修正. The "与我们的产品" table on
  the paper lists **Mimetas OrganoPlate ⭐⭐⭐⭐ (直接对标: Phaseguide
  微流控技术)** + **CelVivo ClinoStar ⭐⭐⭐ (类器官前段成熟期培养:
  BVO 在 hiPSC 分化到 day 15 需要悬浮旋转培养, ClinoStar 是该步骤
  的金标准; day 15 后才转入芯片, ClinoStar 是完整工作流的前置)** +
  **Emulate Organ-Chip ⭐⭐⭐**.
 - **Guo Z, Zhang N (2026) Front Cell Dev Biol DOI 10.3389/fcell.2026.1721946**
  — an IRB / ethical-review systematic-review paper for organoid
  biomedical research. The paper establishes: (i) **7 大强制要点**
  (样本来源合法性 / 捐赠者知情同意 [unlimited expansion / long-term
  cryopreservation / inter-lab sharing / cross-border / future
  unspecified research / commercial use / withdrawal mechanism] /
  数据隐私与去标识化 / 共培养产物主体性评估 [Guo 2026 首次提出] /
  动物福利 3R 原则 / 跨境监管合规 [中国 / 美国 / 欧盟 / 日本 / 韩国
  对照表] / 长期保存与终止使用); (ii) **中国 IRB 实务视角 + 国际
  ISSCR / GDPR / OHRP 双重参照** (作者团队 = 嘉兴市第一医院医学伦理
  委员会 + 嘉兴大学医学院, 中国 IRB 实践者); (iii) **共培养产物
  "新伦理实体" 框架** = 类器官 + 免疫细胞共培养 (CAR-T 培养) 不构成
  "新生物体" 但构成 "新伦理实体", 需要独立审查. The 3 commits are
  the same single file
  `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md`
  walked through Robin's standard LDR cycle: (a) **`2e6f5989`** adds
  the file (170 lines, single-pass entry); (b) **`00f824f2`** -v2 修
  图床 (加 2 张 Wiki.js 自带图); (c) **`a4fa5a32`** -v3 补 Fig 1
  (3 张图全) — Fig 1 is the "类器官共培养模型" 概念图 (Robin 8-16
  实战反思: 综述类概念图通常较小, 提取阈值要从 0KB 起步全收, 再按
  caption 关联; 之前 >200KB 过滤漏了 Fig 1). The "与我们的产品"
  table on the paper lists **CelVivo ClinoStar ⭐⭐⭐⭐ (临床转化类
  器官的伦理合规——本文 7 大要点直接适用于 ClinoStar 客户 IRB 申请;
  Robin 推广 ClinoStar 给三甲医院时, 可附带本框架作为增值)** +
  **Mimetas OrganoPlate ⭐⭐⭐⭐ (类器官共培养芯片的伦理审查依据——
  Mimetas 主打"类器官 + 免疫细胞共培养", 本文主题 B 的共培养伦理
  框架直接适用)** + **Emulate Organ-Chip ⭐⭐⭐ (类器官 + 微流控
  芯片的跨境监管参考)**.
 The **2026-08-12 cluster** is a **single-paper LDR cycle** on
 **Liang Y et al. (2026) Sci Rep DOI 10.1038/s41598-026-42990-2** — a
 mouse liver organoid platform paper from 澳门科技大学 + 香港大学 that
@@ -175,6 +293,21 @@ working tree this fetch:
 — the **first entry in a new `Review/` subfolder** (see the
 Notable-entity section below).
 **7 new vault commits landed in the 2026-08-15T18:07Z →
 2026-08-17T18:09Z window** — the vault HEAD bumped from `297f106d`
 to `a4fa5a32`. The two 2026-08-16 LDR cycles (Quintard 2024
 microfluidic organ-on-chip + Guo 2026 organoid ethics systematic
 review) are the **first time since the 2026-07-28 / 2026-07-29
 Parate / Lee / Hodge cluster** that two new paper deep-reads landed
 on `main` in the same 48-hour window. The 2026-08-16 cluster
 replaces the 2026-08-12 Liang 2026 cluster as the most recent
 committed vault activity. Two new untracked directories appeared in
 the working tree this fetch: `celvivo_commercial/1331651_20260630_131201.pdf`
 (the 6-30 quote PDF migrated into a new folder) + `templates/类器官IRB申请清单.md`
 (the IRB application checklist derived from Guo 2026 — Robin's first
 customer-facing sales ammunition template produced from a single
 deep-read; see the Notable-entity section below for synthesis).
 The **2026-08-10 cluster** is a **frontmatter-hygiene + MOC-discipline
 sprint** rather than new external evidence: (a) **Phase A batch**
 (`d97b39ed`) standardized 6 deep-read notes with the structured 6-field
@@ -198,60 +331,148 @@ indexed on [`/sources/literature.md`](/sources/literature.md). The
 `1614ccf9`) are the 8-step SOP rewrite cycle (v3 → v11) Robin re-ran
 on the same paper.
-## openwiki-wiki — working-tree status (2026-08-15)
+## openwiki-wiki — working-tree status (2026-08-21)
 - **Branch:** `main`
- **HEAD:** `2507925e27b83b4f9d2e6f3b9c939d081a90f9f2` (the
+- **HEAD:** `f6c2576` (the
  `chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts
-  (sources-sync 2026-08-15)` commit — see Notable-entity §
+  (sources-sync 2026-08-21)` commit — same auto-source-sync job that
-  "2026-08-15 sources-sync bug" for the count-data wipe this commit
+  carried the 2026-08-15 count-data wipe + re-applied the pattern on
-  carried into the source pages).
+  2026-08-16 + 2026-08-17 + 2026-08-18 + 2026-08-19 + 2026-08-20 + now
- **Working-tree state:** 10 modified files (uncommitted — pending next
+  2026-08-21; see Notable-entity § "2026-08-15 sources-sync bug" for the
-  CLI orchestration). The dirty file set is the **accumulated
+  operational note). The 2026-08-21T18:09Z fetch observed wiki HEAD
-  synthesis-layer edits from the prior 3 runs in this same 24-hour
+  bumped from `bd30339` (2026-08-20T18:09Z fetch) to `f6c2576` —
-  window** (HN-1 2026-08-13 + HN-1 2026-08-15 + web-search-1 2026-08-15
+  **2 new automated wiki commits** in the 2026-08-20T18:09Z →
-  + this git-repo-1 2026-08-15 run). The 10 dirty files are:
+  2026-08-21T18:09Z 24-hour window: (a) `b6dc337` chore: daily update
  2026-08-21 (2026-08-21 02:27 +0800); (b) `f6c2576` chore(sources):
  refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync
  2026-08-21, 2026-08-21 02:30 +0800). Both commits are routine
  auto-orchestration — the `b6dc337` daily update carried the
  synthesis-layer edits from the prior HN-1 2026-08-21T18:00Z +
  web-search-1 2026-08-21 (skipped) + git-repo-1 2026-08-20T18:09Z
  runs; the `f6c2576` sources-sync re-applied the count-data wipe
  pattern on NocoDB / SeaFile / Wiki.js / RAGFlow for the **seventh**
  consecutive time (after `997b648` 2026-08-16 + `be49285`
  2026-08-17 + `1fc73ae` 2026-08-18 + `dcb53a2` 2026-08-19 +
  `bd30339` 2026-08-20 + now `f6c2576` 2026-08-21).
 - **Working-tree state:** 9 modified files (uncommitted — pending
  next CLI orchestration). The 2026-08-21T18:09Z fetch observed the
  working tree drop from 10 uncommitted files (per the 2026-08-20T18:09Z
  fetch) to 9 uncommitted files (per `git status` at the 2026-08-21
  fetch) — the `sources/index.md` file that was re-appearing as dirty
  in the working tree at the 2026-08-20 fetch has now been committed
  by `b6dc337` 2026-08-21 daily update. The 9 dirty files at this
  fetch are:
  - `.last-update.json` — CLI metadata, will be updated when this run's
    `status: complete` lands.
  - `quickstart.md` — contains the accumulated "Latest update"
    paragraphs from the prior HN-1 2026-08-15 + web-search-1 2026-08-15
-    + git-repo-1 2026-08-13 runs, plus the new "Latest update —
+    + git-repo-1 2026-08-13 runs, plus the "Latest update —
-    git-repo-1 (2026-08-15T18:07Z)" paragraph this run is adding.
+    git-repo-1 (2026-08-15T18:07Z)" + "Latest update — git-repo-1
    (2026-08-17T18:09Z)" + "Latest update — git-repo-1
    (2026-08-18T18:10Z)" + "Latest update — git-repo-1
    (2026-08-19T18:08Z)" + "Latest update — git-repo-1
    (2026-08-20T18:09Z)" paragraphs added by the 2026-08-15 +
    2026-08-17 + 2026-08-18 + 2026-08-19 + 2026-08-20 git-repo runs;
    this git-repo-1 2026-08-21T18:09Z run adds the "Latest update —
    git-repo-1 (2026-08-21T18:09Z)" paragraph and updates the
    Backlog git-repo entry to reflect the new wiki HEAD `f6c2576`.
  - `sources/README.md` — refreshed connector-roll table row for
-    web-search-1 (added the 2026-08-15 skip to the 4-entry skip streak)
+    web-search-1 (added the 2026-08-15 + 2026-08-17 + 2026-08-18 +
-    + added frontmatter placeholders to nocodb.md / ragflow.md /
+    2026-08-19 + 2026-08-20 + 2026-08-21 skips to the 9-entry skip
    streak) + added frontmatter placeholders to nocodb.md / ragflow.md /
    seafile.md / wikijs.md during the 2026-08-15 daily update.
  - `sources/hackernews.md` — accumulated "Latest update —
-    2026-08-15 18:00 UTC" section from the HN-1 2026-08-15 run (Auto-research
+    2026-08-15 18:00 UTC" + "Latest update — 2026-08-16 18:00 UTC" +
-    with codex 232x Faster Kernel flag-for-traceability + Working with AI
+    "Latest update — 2026-08-17 18:00 UTC" + "Latest update —
-    as Leadership + Yadda 3.0.0 BDD adjacent-off-scope callout section +
+    2026-08-18 18:00 UTC" + "Latest update — 2026-08-19 18:00 UTC"
-    4th consecutive fully-zero Algolia lane streak note) — landed in
+    + "Latest update — 2026-08-20 18:00 UTC" + "Latest update —
-    uncommitted state during the HN-1 2026-08-15 run.
+    2026-08-21 18:00 UTC" sections from the prior HN-1 runs
-  - `sources/index.md` — accumulated description-only edits for
+    (Auto-research with codex 232x Faster Kernel + Anthropic
-    nocodb.md / ragflow.md / seafile.md / wikijs.md (frontmatter was
+    multi-agent + Stripe/OpenRouter + Copilot Autofix + Qwen 3.8
-    re-applied by the 2026-08-15 daily update, description lines
+    27B + Agent Mesh + machine0 YC S26 + Amazon order emails
-    removed since they no longer match the placeholder scheme).
+    AI-agent data + OpenRouter-Stripe formal confirmation + OneCLI
-  - `sources/nocodb.md` — frontmatter re-added during the 2026-08-15
+    + Extensible Software + Frugal Tokens + the Nature brain
-    daily update; **count data wiped** by `2507925` sources-sync
+    organoid time-passage paper + Anthropic Claude Code AGENTS.md
-    (NocoDB went from 6614 → 0 records).
+    feature request + Unsloth Dynamic 3.0 GGUFs + DeepSeek-v4-flash-
-  - `sources/ragflow.md` — frontmatter re-added during the 2026-08-15
+    vision-exp + Show HN Proliferate + self-hosted sandboxed agentic
-    daily update; **count data wiped** by `2507925` sources-sync
+    software factory + GitHub August 17 outage post-mortem +
-    (landing went from 200 → 000).
+    LiteLLM hiring flag-for-traceability callouts + the 4th / 5th /
-  - `sources/seafile.md` — frontmatter re-added during the 2026-08-15
+    6th / 7th / 8th / 9th / 10th consecutive empty / noise-only
-    daily update; **count data wiped** by `2507925` sources-sync
+    Algolia lane streak notes) — landed in uncommitted state during
-    (libraries table emptied).
+    the HN-1 runs.
  - `sources/nocodb.md` — `openwiki_generated: true` placeholder
    frontmatter auto-applied during the 2026-08-15 daily update +
    carried forward in 2026-08-16 + 2026-08-17 + 2026-08-18 +
    2026-08-19 + 2026-08-20 + 2026-08-21 daily updates; **placeholder
    resolved by the 2026-08-18T18:10Z update run** (proper `type` /
    `title` / `description` / `tags` frontmatter now in place);
    **count data wiped** by `2507925` 2026-08-15 sources-sync (NocoDB
    went from 6614 → 0 records) and the wipe persists across the 6
    subsequent sources-syncs (`997b648` 2026-08-16 + `be49285`
    2026-08-17 + `1fc73ae` 2026-08-18 + `dcb53a2` 2026-08-19 +
    `bd30339` 2026-08-20 + now `f6c2576` 2026-08-21 — the count
    stays at 0 across all 7 sources-syncs); body content (13
    literature tables + record counts from `1737454` baseline)
    remains intact.
  - `sources/ragflow.md` — same `openwiki_generated: true` placeholder
    auto-applied during the 2026-08-15 daily update;
    **placeholder resolved by the 2026-08-18T18:10Z update run**
    (proper `type` / `title` / `description` / `tags` frontmatter now
    in place); **count data wiped** by `2507925` 2026-08-15
    sources-sync (landing went from 200 → 000); body content (14 KBs +
    service-availability table + degraded-path note) remains intact.
  - `sources/seafile.md` — same `openwiki_generated: true` placeholder
    auto-applied during the 2026-08-15 daily update;
    **placeholder resolved by the 2026-08-18T18:10Z update run**
    (proper `type` / `title` / `description` / `tags` frontmatter now
    in place); **count data wiped** by `2507925` 2026-08-15
    sources-sync (libraries table emptied — SeaFile was already empty
    in `1737454` already — a separate, older cron issue not introduced
    by `2507925`); body content (API config + integration chain)
    remains intact.
  - `sources/web-search.md` — accumulated "2026-08-15 attempted
-    update — skipped" section from the web-search-1 2026-08-15 run
+    update — skipped" + "2026-08-17 attempted update — skipped" +
-    (4th consecutive skip).
+    "2026-08-18 attempted update — skipped" + "2026-08-19 attempted
-  - `sources/wikijs.md` — frontmatter re-added during the 2026-08-15
+    update — skipped" + "2026-08-20 attempted update — skipped" +
-    daily update; **count data wiped** by `2507925` sources-sync
+    "2026-08-21 attempted update — skipped" sections from the
-    (Wiki.js went from 83 → 0 unique pages; ID range 22..1704 → 0..0).
+    web-search-1 2026-08-15 + web-search-1 2026-08-17 + web-search-1
    2026-08-18 + web-search-1 2026-08-19 + web-search-1 2026-08-20 +
    web-search-1 2026-08-21 runs (5th + 6th + 7th + 8th + 9th + 10th
    consecutive skips on the same code path).
  - `sources/wikijs.md` — same `openwiki_generated: true` placeholder
    auto-applied during the 2026-08-15 daily update; **count data
    wiped** by `2507925` 2026-08-15 sources-sync (Wiki.js went from
    83 → 0 unique pages; ID range 22..1704 → 0..0) and the wipe
    persists across the 6 subsequent sources-syncs (`997b648`
    2026-08-16 + `be49285` 2026-08-17 + `1fc73ae` 2026-08-18 +
    `dcb53a2` 2026-08-19 + `bd30339` 2026-08-20 + now `f6c2576`
    2026-08-21).
 - **Auth:** local path only — no remote, no credentials.
 - **New file in this window:** `sources/openwiki-version-drift.md`
  was created in the 2026-08-17 daily update commit `5c70881` (auto-
  generated page that tracks OpenWiki installed-vs-npm-latest version
  drift; reports v0.3.1 local → v0.3.3 npm latest as of
  2026-08-15T20:00:03Z; the page sits on the wiki to surface the
  drift without an external daemon).
 - **Auth:** local path only — no remote, no credentials.
 ### Recent commits (latest first)
 | Date | Hash | Note |
 | --- | --- | --- |
 | 2026-08-21 | `f6c2576` | chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-21) — **count-data wipe re-applied** for the **seventh** consecutive sources-sync (after 2026-08-15 `2507925` + 2026-08-16 `997b648` + 2026-08-17 `be49285` + 2026-08-18 `1fc73ae` + 2026-08-19 `dcb53a2` + 2026-08-20 `bd30339`); see Notable-entity § "2026-08-15 sources-sync bug" |
 | 2026-08-21 | `b6dc337` | chore: daily update 2026-08-21 (synthesis-layer edits accumulated from the prior HN-1 2026-08-21T18:00Z + web-search-1 2026-08-21 (skipped) + git-repo-1 2026-08-20T18:09Z runs; committed `sources/index.md` from the 2026-08-20 dirty set) |
 | 2026-08-20 | `bd30339` | chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-20) — **count-data wipe re-applied** for the **sixth** consecutive sources-sync (after 2026-08-15 `2507925` + 2026-08-16 `997b648` + 2026-08-17 `be49285` + 2026-08-18 `1fc73ae` + 2026-08-19 `dcb53a2`); see Notable-entity § "2026-08-15 sources-sync bug" |
 | 2026-08-20 | `a44f284` | chore: daily update 2026-08-20 (synthesis-layer edits accumulated from the prior HN-1 2026-08-20T18:00Z + web-search-1 2026-08-20 (skipped) + git-repo-1 2026-08-19T18:08Z runs) |
 | 2026-08-19 | `dcb53a2` | chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-19) — **count-data wipe re-applied** for the **fifth** consecutive sources-sync (after 2026-08-15 `2507925` + 2026-08-16 `997b648` + 2026-08-17 `be49285` + 2026-08-18 `1fc73ae`); see Notable-entity § "2026-08-15 sources-sync bug" |
 | 2026-08-19 | `7e904ec` | chore: daily update 2026-08-19 (synthesis-layer edits accumulated from the prior HN-1 2026-08-19T18:00Z + web-search-1 2026-08-19 + git-repo-1 2026-08-18T18:10Z runs + the prior `sources/openwiki-version-drift.md` carryover) |
 | 2026-08-18 | `1fc73ae` | chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-18) — **count-data wipe re-applied** for the **fourth** consecutive sources-sync (after 2026-08-15 `2507925` + 2026-08-16 `997b648` + 2026-08-17 `be49285`); see Notable-entity § "2026-08-15 sources-sync bug" |
 | 2026-08-18 | `8127797` | chore: daily update 2026-08-18 (synthesis-layer edits accumulated from the prior HN-1 2026-08-18T18:00Z + git-repo-1 2026-08-17T18:09Z runs + the new `sources/openwiki-version-drift.md` carryover) |
 | 2026-08-17 | `be49285` | chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-17) |
 | 2026-08-17 | `5c70881` | chore: daily update 2026-08-17 (added `sources/openwiki-version-drift.md` auto-generated page + refreshed HN-1 / web-search-1 / git-repo-1 sections) |
 | 2026-08-16 | `997b648` | chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-16) |
 | 2026-08-16 | `151d22b` | chore: daily update 2026-08-16 (committed `sources/index.md` from the 2026-08-15 dirty set; refreshed HN-1 / web-search-1 / git-repo-1 / themes/05-robin-research sections) |
 | 2026-08-15 | `2507925` | chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-15) — **count-data wipe** (NocoDB 6614 → 0, Wiki.js 83 → 0, RAGFlow landing 200 → 000); see Notable-entity § "2026-08-15 sources-sync bug" |
 | 2026-08-15 | `173b58c` | chore: daily update 2026-08-15 (added OKF frontmatter to nocodb.md / ragflow.md / seafile.md / wikijs.md) |
 | 2026-08-14 | `6258717` | chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-14) |
@@ -316,14 +537,18 @@ from 2026-08-11 / 2026-08-12 (`7556e31` / `431ee6a` daily +
 next wiki commit should add a fuller Liang 2026 row when the synthesis
 pipeline catches up.
-### Summary of last 24 hours
+### Summary of last 48 hours
 | Window (UTC) | Vault | Wiki |
 | --- | --- | --- |
-| 2026-08-13T18:08:25Z → 2026-08-15T18:07:49Z | HEAD `297f106d` → `297f106d` (**0 new commits**; the 2026-08-12 Liang 2026 4-commit LDR cycle remains the most recent vault activity across both 2026-08-13 and 2026-08-15 fetches) | HEAD `1737454` → `2507925` (**4 new commits**: `021e929` daily update 2026-08-14 + `6258717` sources-sync 2026-08-14 + `173b58c` daily update 2026-08-15 + `2507925` sources-sync 2026-08-15) |
+| 2026-08-15T18:07:49Z → 2026-08-17T18:09:32Z | HEAD `297f106d` → `a4fa5a32` (**7 new commits**: `0fc8db24` + `290e9635` + `24c713de` + `4073abf4` Quintard 2024 Nat Commun microfluidic vascularized organoid chip 4-commit LDR cycle + `2e6f5989` + `00f824f2` + `a4fa5a32` Guo 2026 Front Cell Dev Biol organoid ethics systematic review 3-commit LDR cycle — **first time since the 2026-07-28 / 2026-07-29 Parate / Lee / Hodge cluster that two new paper deep-reads landed on `main` in the same 48-hour window**) | HEAD `2507925` → `be49285` (**4 new commits**: `151d22b` daily update 2026-08-16 + `997b648` sources-sync 2026-08-16 + `5c70881` daily update 2026-08-17 + `be49285` sources-sync 2026-08-17) |
-| **Net new external evidence** | **none** — vault HEAD unchanged, untracked file set unchanged (the `Review/zhou2023_computer_vision_microfluidics.md` first-entry-in-Review/-subfolder is still untracked, carrying forward from the 2026-08-13 fetch) | **none** — synthesis layer only (HN-1 2026-08-13 MCP Memory using OKF refresh + HN-1 2026-08-15 Auto-research with codex flag-for-traceability + web-search-1 2026-08-15 4th-skip streak note all committed earlier; this run's edits are pending the next CLI commit) |
+| 2026-08-17T18:09:32Z → 2026-08-18T18:10:12Z | HEAD **unchanged** at `a4fa5a32` (**0 new commits**, **0 new mtime changes** — vault is silent in this 24-hour window; the 2026-08-16 Quintard 2024 + Guo 2026 cluster remains the most recent vault activity) | HEAD `be49285` → `1fc73ae` (**2 new automated commits**: `8127797` chore: daily update 2026-08-18 + `1fc73ae` chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-18, the **fourth** consecutive sources-sync re-applying the `2507925` 2026-08-15 count-data wipe pattern)) |
-| Untracked → committed migrations | none | none — the 10 dirty files (`.last-update.json` + `quickstart.md` + `sources/{README,hackernews,index,nocodb,ragflow,seafile,web-search,wikijs}.md`) are uncommitted synthesis edits accumulated across the prior HN-1 2026-08-13 + HN-1 2026-08-15 + web-search-1 2026-08-15 + git-repo-1 2026-08-15 runs, awaiting the next CLI commit cycle |
+| 2026-08-19T18:08:24Z → 2026-08-20T18:09:15Z | HEAD **unchanged** at `a4fa5a32` (**0 new commits**, **0 new mtime changes** — vault is silent in this 24-hour window for the **4th consecutive fetch**; the 2026-08-16 Quintard 2024 + Guo 2026 cluster remains the most recent vault activity, **4 calendar days stale**) | HEAD `dcb53a2` → `bd30339` (**2 new automated commits**: `a44f284` chore: daily update 2026-08-20 + `bd30339` chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-20, the **sixth** consecutive sources-sync re-applying the `2507925` 2026-08-15 count-data wipe pattern after `997b648` 2026-08-16 + `be49285` 2026-08-17 + `1fc73ae` 2026-08-18 + `dcb53a2` 2026-08-19 + now `bd30339` 2026-08-20)) |
-| **Operational issue surfaced this run** | n/a | **`2507925` 2026-08-15 sources-sync bug**: this sync committed empty NocoDB / SeaFile / Wiki.js / RAGFlow count values (NocoDB 6614 → 0, Wiki.js 83 → 0, RAGFlow landing 200 → 000). The on-disk `~/.openwiki/connectors/web-search/config.json` is unaffected — this is a wiki-side CRON issue with the auto-source-sync job, not a connector config issue. Recorded for traceability on `/sources/git-repo.md` Notable-entity § "2026-08-15 sources-sync bug" and on each affected `/sources/{nocodb,ragflow,seafile,wikijs}.md` page (each of those pages now shows `上次同步: 2026-08-14T18:30:42Z` — the prior successful sync — plus zero / null / 000 count values from the failed 2026-08-15 sync). The data is recoverable from `git show 8ddc6d9:sources/nocodb.md` etc. for any future recovery commit |
+| 2026-08-18T18:10:12Z → 2026-08-19T18:08:24Z | HEAD **unchanged** at `a4fa5a32` (**0 new commits**, **0 new mtime changes** — vault is silent in this 24-hour window for the **3rd consecutive fetch**; the 2026-08-16 Quintard 2024 + Guo 2026 cluster remains the most recent vault activity, **3 calendar days stale**) | HEAD `1fc73ae` → `dcb53a2` (**2 new automated commits**: `7e904ec` chore: daily update 2026-08-19 + `dcb53a2` chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-19, the **fifth** consecutive sources-sync re-applying the `2507925` 2026-08-15 count-data wipe pattern after `997b648` 2026-08-16 + `be49285` 2026-08-17 + `1fc73ae` 2026-08-18 + now `dcb53a2` 2026-08-19)) |
 | 2026-08-20T18:09:15Z → 2026-08-21T18:09:00Z | HEAD **unchanged** at `a4fa5a32` (**0 new commits**, **0 new mtime changes** — vault is silent in this 24-hour window for the **5th consecutive fetch**; the 2026-08-16 Quintard 2024 + Guo 2026 cluster remains the most recent vault activity, **5 calendar days stale**) | HEAD `bd30339` → `f6c2576` (**2 new automated commits**: `b6dc337` chore: daily update 2026-08-21 + `f6c2576` chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-21, the **seventh** consecutive sources-sync re-applying the `2507925` 2026-08-15 count-data wipe pattern after `997b648` 2026-08-16 + `be49285` 2026-08-17 + `1fc73ae` 2026-08-18 + `dcb53a2` 2026-08-19 + `bd30339` 2026-08-20 + now `f6c2576` 2026-08-21)) |
 | **Net new external evidence** | **2 new paper deep-reads** (from the 2026-08-15T18:07Z → 2026-08-17T18:09Z window): Quintard 2024 Nat Commun microfluidic vascularized organoid chip + Guo 2026 Front Cell Dev Biol organoid ethics systematic review. **2 new untracked directories** (from the same window): `celvivo_commercial/1331651_20260630_131201.pdf` (the 6-30 quote PDF migrated into a new folder) + `templates/类器官IRB申请清单.md` (the IRB application checklist derived from Guo 2026 — Robin's first customer-facing sales ammunition template produced from a single deep-read). The `Review/zhou2023_computer_vision_microfluidics.md` first-entry-in-Review/-subfolder is still untracked, carrying forward from the 2026-08-13 fetch (**10-day carry-forward** at the 2026-08-21T18:09Z fetch — was 9-day at the 2026-08-20T18:09Z fetch). **No new vault evidence in the 2026-08-20T18:09Z → 2026-08-21T18:09Z 24-hour window** | **1 new wiki file** (from the 2026-08-17 daily update `5c70881`): `sources/openwiki-version-drift.md` (auto-generated OpenWiki version-drift monitor; v0.3.1 local → v0.3.3 npm latest as of 2026-08-15T20:00:03Z). **Wiki-side**: the 2026-08-21T18:09Z fetch observed wiki HEAD bump `bd30339` → `f6c2576` — 2 new automated wiki commits (`b6dc337` daily update 2026-08-21 + `f6c2576` sources-sync 2026-08-21 — the **seventh** consecutive sources-sync re-applying the `2507925` 2026-08-15 count-data wipe pattern). Synthesis-layer edits accumulated across the prior HN-1 2026-08-13 + HN-1 2026-08-15 + HN-1 2026-08-16 + HN-1 2026-08-17 + HN-1 2026-08-18 + HN-1 2026-08-19 + HN-1 2026-08-20 + HN-1 2026-08-21 + web-search-1 2026-08-15 + web-search-1 2026-08-17 + web-search-1 2026-08-18 + web-search-1 2026-08-19 + web-search-1 2026-08-20 (skipped) + web-search-1 2026-08-21 (skipped) + git-repo-1 2026-08-13 + git-repo-1 2026-08-15 + git-repo-1 2026-08-17 + git-repo-1 2026-08-18 + git-repo-1 2026-08-19 + git-repo-1 2026-08-20 + this git-repo-1 2026-08-21 runs are pending the next CLI commit cycle |
 | Untracked → committed migrations | **Quintard 2024 file (4 commits)** + **Guo 2026 file (3 commits)** all moved from absent → committed on `main` (in the 2026-08-15T18:07Z → 2026-08-17T18:09Z window); **the 2 new untracked directories** are net-new in the same window. **None** in the 2026-08-17T18:09Z → 2026-08-18T18:10Z 24-hour window (vault silent) or the 2026-08-18T18:10Z → 2026-08-19T18:08Z 24-hour window (vault silent for the 3rd consecutive fetch) or the 2026-08-19T18:08Z → 2026-08-20T18:09Z 24-hour window (vault silent for the 4th consecutive fetch) or the 2026-08-20T18:09Z → 2026-08-21T18:09Z 24-hour window (vault silent for the 5th consecutive fetch). | **2026-08-15T18:07Z → 2026-08-17T18:09Z window**: the `sources/index.md` from the 2026-08-15 dirty set was committed by the 2026-08-16 daily update `151d22b`; the remaining 9 dirty files are uncommitted synthesis edits accumulated across the prior HN-1 + web-search-1 + git-repo-1 runs. **2026-08-17T18:09Z → 2026-08-18T18:10Z window**: the `8127797` 2026-08-18 daily update committed a subset of the synthesis-layer edits from the prior HN-1 2026-08-18T18:00Z + git-repo-1 2026-08-17T18:09Z runs (touching `commitments.md` + `index.md` + `quickstart.md` + `sources/{README,git-repo,hackernews,index,literature,nocodb,ragflow,seafile,web-search,wikijs}.md` + `themes/{01-organoid-equipment,05-robin-research}.md` per `git show --stat 8127797`); the 9 dirty files re-appear in the working tree because the very next synthesis edits from this git-repo-1 2026-08-18T18:10Z run re-touch the same files. **2026-08-18T18:10Z → 2026-08-19T18:08Z window**: the `7e904ec` 2026-08-19 daily update committed a subset of the synthesis-layer edits from the prior HN-1 2026-08-19T18:00Z + web-search-1 2026-08-19 + git-repo-1 2026-08-18T18:10Z runs (touching `.last-update.json` + `quickstart.md` + `sources/{README,git-repo,hackernews,index,nocodb,ragflow,seafile,web-search,wikijs}.md` + `themes/05-robin-research.md` per `git show --stat 7e904ec`); the 10 dirty files (`.last-update.json` + `quickstart.md` + `sources/{README,hackernews,index,nocodb,ragflow,seafile,web-search,wikijs}.md`) re-appear in the working tree because the very next synthesis edits from this git-repo-1 2026-08-19T18:08Z run re-touch the same files. **2026-08-19T18:08Z → 2026-08-20T18:09Z window**: the `a44f284` 2026-08-20 daily update committed a subset of the synthesis-layer edits from the prior HN-1 2026-08-20T18:00Z + web-search-1 2026-08-20 (skipped) + git-repo-1 2026-08-19T18:08Z runs; the 10 dirty files re-appear in the working tree because the very next synthesis edits from this git-repo-1 2026-08-20T18:09Z run re-touch the same files. **2026-08-20T18:09Z → 2026-08-21T18:09Z window**: the `b6dc337` 2026-08-21 daily update committed a subset of the synthesis-layer edits from the prior HN-1 2026-08-21T18:00Z + web-search-1 2026-08-21 (skipped) + git-repo-1 2026-08-20T18:09Z runs; **`sources/index.md` was committed by `b6dc337`** (was re-appearing as dirty since 2026-08-16 daily update). The 9 dirty files (`.last-update.json` + `quickstart.md` + `sources/{README,hackernews,nocodb,ragflow,seafile,web-search,wikijs}.md`) re-appear in the working tree because the very next synthesis edits from this git-repo-1 2026-08-21T18:09Z run re-touch the same files. The 9 dirty files are awaiting the next CLI commit cycle |
 | **Operational issue carried over from prior runs** | n/a | **`2507925` 2026-08-15 sources-sync bug** + the 2026-08-16 `997b648` + 2026-08-17 `be49285` + 2026-08-18 `1fc73ae` + 2026-08-19 `dcb53a2` + 2026-08-20 `bd30339` + 2026-08-21 `f6c2576` sources-syncs (which re-applied the same operational pattern as `2507925` — NocoDB / Wiki.js / RAGFlow count values stayed zero across all **7** sources-syncs). The on-disk `~/.openwiki/connectors/web-search/config.json` is unaffected — this is a wiki-side CRON issue with the auto-source-sync job, not a connector config issue. Recorded for traceability on `/sources/git-repo.md` Notable-entity § "2026-08-15 sources-sync bug" and on each affected `/sources/{nocodb,ragflow,seafile,wikijs}.md` page. The data is recoverable from `git show 8ddc6d9:sources/nocodb.md` etc. for any future recovery commit |
 ## Vault navigation index
@@ -357,7 +582,7 @@ Markdown file counts per deep-read subfolder:
 | Subfolder | .md count |
 | --- | --- |
-| `Organoid/` | 659 |
+| `Organoid/` | 661 (+2 from 2026-08-16 — Quintard 2024 Nat Commun microfluidic vascularized organoid chip + Guo 2026 Front Cell Dev Biol organoid ethics systematic review) |
 | `Celvivo/` | 142 |
 | `3Brain/` | 136 |
 | `Cellink/` | 129 |
@@ -375,14 +600,14 @@ Markdown file counts per deep-read subfolder:
 | `Retinal/` | 1 |
 | `Microbioreactor/` | 1 (new as of 2026-08-07 — Rosero 2026 Front Bioeng Biotechnol) |
 | `Cells/` | 1 (new as of 2026-08-08 — Fernandez Vallone 2026 Cells THSDC) |
-| `Review/` | 1 (new as of 2026-08-13 — Zhou 2023 computer vision + microfluidics, **untracked**) |
+| `Review/` | 1 (new as of 2026-08-13 — Zhou 2023 computer vision + microfluidics, **untracked**, **8-day carry-forward** at 2026-08-19 fetch, **6 fetches silent** — structural signal continuing to weaken) |
 | `templates/` | 1 (new as of 2026-08-17 — `类器官IRB申请清单.md`, derived from the Guo 2026 ethics deep-read; Robin's first customer-facing template produced from a single deep-read, **untracked**, **4-day carry-forward** at 2026-08-20 fetch (was 3-day at 2026-08-19) |
 | `celvivo_commercial/` | 1 (new as of 2026-08-17 — `1331651_20260630_131201.pdf`, the 6-30 quote PDF migrated into a new folder, **untracked**, **4-day carry-forward** at 2026-08-20 fetch (was 3-day at 2026-08-19) |
-Total ≈ 1,205 deep-read notes (+1 from the 2026-08-13 cluster:
+Total ≈ 1,207 deep-read notes on `main` (+2 from the 2026-08-16 Quintard 2024 + Guo 2026 clusters).
 Review/ zhou2023 computer vision + microfluidics, **untracked** — only
-counts once committed). The 2026-08-07 / 2026-08-08 cluster (Microbioreactor
+counts once committed; +2 working-tree files in the new `templates/` +
-+ Cells) remains the most recent committed deep-read additions. CelVivo,
+`celvivo_commercial/` directories, both untracked). The 2026-08-16 Quintard 2024 + Guo 2026 cluster is the most recent committed deep-read additions; the 2026-08-07 / 2026-08-08 cluster (Microbioreactor + Cells) remains the prior committed cluster. CelVivo, 3Brain, Cellink, and the broad `Organoid/` bucket cover Robin's product KB per the wiki goal focus areas (类器官培养与设备, 3D 生物打印). The new `templates/` folder signals Robin may be formalizing customer-facing deliverables (checklists / templates / sales scripts) as a separate vault subtree — the IRB application checklist is the first such artifact.
 3Brain, Cellink, and the broad `Organoid/` bucket cover Robin's product
 KB per the wiki goal focus areas (类器官培养与设备, 3D 生物打印).
 ## Distributor map refresh (2026-08-07)
@@ -443,7 +668,11 @@ fields still 待补).
 ## Notable entities surfaced by the vault (structural hints only)
- **Review/ subfolder — first entry (2026-08-13, still uncommitted at 2026-08-15)** — `obsidian-vault/04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md` is the **first file in a new `Review/` subfolder** under `04-Literature/Deep-Reads/`. The file is **untracked** at the 2026-08-15 fetch (Robin has not yet committed it — same state as the 2026-08-13 fetch, 0 progress in the 2026-08-13 → 2026-08-15 24-hour window), so the synthesis is provisional, but the path naming convention (`zhou2023_computer_vision_microfluidics.md`) matches Robin's standard deep-read naming pattern (`author-year-keyword-keyword.md`). Likely content: Zhou et al. (2023) computer-vision + microfluidics cross-review paper — a **review-type** paper (rather than an original-research paper) that Robin is collecting as part of his broader organoid + microfluidic cross-anchor reading list. **Structural significance**: the `Review/` subfolder is new — none of the existing 19 subfolders (`Organoid/`, `Celvivo/`, `3Brain/`, `Cellink/`, `Organoid-List/`, `Product-Reports/`, `Brain/`, `Brain-Tumor/`, `Cancer/`, `Liver/`, `Other/`, `RegenMed/`, `3Brain MEA/`, `Cardiac/`, `Kidney/`, `Retinal/`, `Microbioreactor/`, `Cells/`) explicitly segregates review-type papers. A `Review/` subfolder signals Robin may be formalizing the review-paper stream separately from the original-research stream. **No synthesis routes** until the file is committed — the deep-read synthesis page + any vendor-mapping should land after Robin commits the file and the standard 8-step LDR pipeline publishes it to Wiki.js / NocoDB / SeaFile. Track on the next git-repo fetch whether (a) the file is committed, (b) the `Review/` subfolder accumulates additional entries, and (c) the standard page-946 9 项 SOP + page-934 修齐 alignment is applied. **Carry-forward status** (2026-08-13 → 2026-08-15): unchanged. The `Review/` subfolder is still single-entry, still untracked, no follow-up paper landed in this subfolder in the 48-hour window since the first observation. Watchlist trigger: if the file remains uncommitted at the next fetch (2026-08-17 or later), the structural signal weakens (single-entry subfolder could be a one-off rather than a recurring pattern).
+- **Quintard 2024 Nat Commun microfluidic vascularized organoid chip (2026-08-16, 7 commits in 48-hour window)** — `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` (189 lines; 4-commit LDR cycle `0fc8db24` adds → `290e9635` -v2 修图床/双 H1/落款 → `24c713de` -v3 Wiki.js 自带图床 6 张图 → `4073abf4` -v4 转发语标题/落款加粗/删 3Brain; Wiki IDs 1719/1720/1722, NocoDB Id 3297). The paper is **the first microfluidic / organ-on-chip platform paper** Robin has deep-read in the 2026-08 window; the platform combines (i) 10-channel parallel microfluidic chips with U-shaped capture sites (300-800 µm adjustable), (ii) fibrin + Matrigel hydrogel layer deposition using Landau-Levich-Bretherton effect, (iii) ~10 s capture efficiency ~100%, (iv) dynamic perfusion 7-30 days with HUVEC + fibroblast co-culture + hiPSC-derived BVO + islet spheroid + lung organoid cross-validation, (v) hierarchical vasculature (37 µm upstream artery-vein + 8 µm BVO capillaries, matching physiological ranges 50-1900 s⁻¹). **Net-new external evidence** in this run (git-repo-1 2026-08-17). The 4-star "与我们的产品" table lists **Mimetas OrganoPlate ⭐⭐⭐⭐** (direct Phaseguide-based vascularized / kidney / intestine organ-on-chip competitor) + **CelVivo ClinoStar ⭐⭐⭐** (upstream workflow step: BVO differentiation day 0-15 needs rotating-wall suspension culture; ClinoStar is the canonical hardware for this stage; the paper's day 15 → chip-on-board handoff is the canonical CelVivo → organ-on-chip workflow) + **Emulate Organ-Chip ⭐⭐⭐** (Colon-Intestine-Liver platform companion). Synthesis routes into `/themes/05-robin-research.md` (新增 by-vendor entry) and `/sources/literature.md` (last-30-days deep-read table). Vendor-anchor mapping: CelVivo-adjacent (workflow upstream) + Mimetas OrganoPlate / Emulate Organ-Chip (organ-on-chip product lane that Robin's portfolio does not currently cover but represents a potential cross-sell if Robin's customers ask "where do I run my CelVivo-matured organoids in a vascularized microenvironment?"). Customer-entry: 药企临床前 (vascularized drug screening) + 微流控 organ-on-chip 平台集成商 (Mimetas / Emulate channel partners) + academic PI (vascular development / diabetes). **Track on next fetch** whether Robin publishes a `/sources/literature-quintard-2024-nat-commun-vasorganoid-chip-deepread.md` synthesis page; the deep-read pipeline currently only carries `liang-2026-celvivo-clinostar-positioning` + `miao-2025-celvivo-clinostar-positioning` + `liu-2026-hd-mea-roadmap-implication` + `sharma-2026-retinal-organoid-mea-cross-sell` — no Quintard synthesis page yet.
 - **Guo 2026 Front Cell Dev Biol organoid ethics systematic review (2026-08-16, 7 commits in 48-hour window)** — `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` (170 lines + 3 真图; 3-commit LDR cycle `2e6f5989` adds → `00f824f2` -v2 修图床 (加 2 张 Wiki.js 自带图) → `a4fa5a32` -v3 补 Fig 1; Wiki ID 1724, NocoDB Id 3298). The paper is **the first organoid-research ethics / IRB systematic review** Robin has deep-read in any window — fills the methodological gap on the IRB-side that the prior clinical-translation evidence (CDE classification + Order No. 818) does not directly cover. The paper structures the IRB review framework as **7 mandatory points** (sample provenance + donor informed consent + data privacy & de-identification + co-culture agency + animal welfare 3R + cross-border regulation + long-term storage & termination); the cross-border table compares China (《人类遗传资源管理条例》+ 《涉及人的生命科学和医学研究伦理审查办法》2023), US (HIPAA + Common Rule + NIH GDS), EU (GDPR + Clinical Trials Regulation 536/2014), Japan, Korea. The 4-star "与我们的产品" table lists **CelVivo ClinoStar ⭐⭐⭐⭐** (clinical-translation IRB compliance — the 7 mandatory points directly apply to ClinoStar customer IRB submissions; **Robin 推广 ClinoStar 给三甲医院时, 可附带本框架作为增值**) + **Mimetas OrganoPlate ⭐⭐⭐⭐** (co-culture ethics — Mimetas 主营类器官 + 免疫细胞共培养, the co-culture agency framework from Guo 2026 point 4 directly applies) + **Emulate Organ-Chip ⭐⭐⭐** (organoid + microfluidic cross-border regulation reference). **Net-new external evidence** in this run (git-repo-1 2026-08-17). Robin translated the paper into a **customer-facing sales ammunition template** at `templates/类器官IRB申请清单.md` (180 lines; 7 mandatory points checklist + 5 customer Q&A + China vs International flow table + 10 attachments + 7 citations; v1.0 dated 2026-08-16, "Robin 8-16 实战沉淀") — see the templates/ entry in the next bullet. Customer-entry: 临床转化型医院 (class A tertiary hospitals running organoid IRB submissions) + 类器官厂家 Robin 培训客户 (the IRB checklist is the canonical "Robin 培训客户 IRB 申请" core material) + academic PI (cross-border collaboration IRB paperwork). **Track on next fetch** whether (a) the templates/ IRB checklist gets committed, (b) the Robin-author attribution in the template is recognized as a wiki-side customer-training artifact, (c) Robin produces a deep-read synthesis page at `/sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md`, and (d) the IRB checklist routes into the existing CelVivo industrial-customers program (which currently lives at `05-Documents/Products/Celvivo/Industrial-Customers/`) as a standard customer-training artifact.
 - **Review/ subfolder — first entry (2026-08-13, still uncommitted at 2026-08-21, 10-day carry-forward, watchlist signal continuing to weaken)** — `obsidian-vault/04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md` is the **first file in a new `Review/` subfolder** under `04-Literature/Deep-Reads/`. The file is **untracked** at the 2026-08-21 fetch (Robin has not yet committed it — same state as the 2026-08-13 + 2026-08-15 + 2026-08-17 + 2026-08-18 + 2026-08-19 + 2026-08-20 fetches, **0 progress in the 2026-08-13 → 2026-08-21 192-hour window**, **8 consecutive fetches silent on the file**). **Watchlist signal continuing to weaken at this fetch**: per the 2026-08-15 watchlist-trigger rubric ("if the file remains uncommitted at the next fetch (2026-08-17 or later), the structural signal weakens"), the `Review/` subfolder at the 2026-08-21 fetch is **still single-entry, still untracked** — the structural signal **continues to weaken** at this fetch (**10-day carry-forward** with no commit, no follow-up paper landed in the subfolder across **8 consecutive fetches**). The `Review/` subfolder is more likely to be a one-off than a recurring pattern. The file should either be committed on a future fetch (which would re-strengthen the signal) or remain untracked indefinitely (which would confirm the one-off interpretation). No synthesis routes until the file is committed.
 - **`templates/` subfolder — first entry (2026-08-16, NEW this run)** — `templates/类器官IRB申请清单.md` (180 lines, mtime 2026-08-16, untracked) is the **first file in a new `templates/` directory** at the vault root. The file is Robin's **first customer-facing sales ammunition template produced from a single deep-read** (the Guo 2026 IRB ethics systematic review). Content: 7 mandatory IRB review points checklist (样本来源/知情同意/数据隐私/共培养主体性/3R 动物福利/跨境监管/长期保存与终止使用) + 5 customer Q&A ("类器官研究要不要 IRB 申请?" / "类器官共培养产品怎么申请 IRB?" / "类器官跨境研究怎么报?" / "3R 原则怎么写?" / "类器官 + 免疫细胞共培养 = CAR-T 体外培养, 算不算新生物体? 伦理上算什么?") + China vs International flow comparison table + 10-row 申请附件清单 + 7 references (Guo 2026 + ISSCR 2021 + OHRP 2016 + GDPR 2018 + China 2023 + China 2019 + Cambridge 2020). The template's `version: v1.0 (2026-08-16, Robin 8-16 实战沉淀)` and `Robin 业务定位: 类器官厂家给三甲医院 IRB 申请的标准模板 + Robin 客户培训材料核心` framing makes it explicit that this is the canonical "Robin 培训客户 IRB 申请" core material. **Structural significance**: the `templates/` directory is new — none of the existing top-level folders (`01-Active-Sales/` / `02-Clients/` / `02-Active-Deals/` / `02-Contacts/` / `03-Product/` / `03-Resources/` / `04-Literature/` / `05-Documents/` / `06-Sales/` / `99-Templates/` / `memory/`) provides a vendor-agnostic customer-training-artifact slot at the vault root. The Obsidian vault already has `99-Templates/` for reusable Obsidian templates (note templates, daily-report templates — per `99-Templates/` size hint 14 .md), but the new `templates/` directory is **for customer-facing sales ammunition**, not Obsidian note templates — a different artifact type. The naming convention overlaps with `99-Templates/` and may need disambiguation; Robin's intent (per the file header) is for this `templates/` to be the **canonical customer-training artifact directory**, distinct from `99-Templates/` Obsidian-note templates. **Customer-entry scenarios** called out in the template: (a) 类器官厂家研发负责人 = IRB 申请准备, (b) Robin 客户开发 = 培训客户 IRB 申请核心材料, (c) 医院 IRB 委员会 = 类器官研究 IRB 审查标准参考, (d) 学术合作方 = 跨境合作时多国法规差异对照. **Carry-forward status** (2026-08-21): untracked, **5-day carry-forward** since first observation (2026-08-17 fetch — was 4-day at the 2026-08-20 fetch), future-commit candidate. **Track on next fetch** whether (a) Robin commits the file to `main`, (b) more templates land in the directory (extending the customer-training-artifact slot), (c) the `templates/` and `99-Templates/` naming overlap gets resolved (rename / docs / conventions). Synthesis routes into `/themes/05-robin-research.md` (sales ammunition pipeline section).
 - **`celvivo_commercial/` subfolder — first entry (2026-08-17, NEW this run)** — `celvivo_commercial/1331651_20260630_131201.pdf` (56 KB PDF, mtime 2026-08-17, untracked) is the **first file in a new `celvivo_commercial/` directory** at the vault root. The PDF is the existing 6-30 quote PDF that Robin migrated into a new folder. The file is **a quote PDF**, not a synthesis target — the on-disk evidence is the existing 6-30 quote document that already exists in `05-Documents/Products/Celvivo/Industrial-Customers/` (per the 2026-08-15 synthesis-policy section above, "commercial docs (8 files: Exhibit 1 Price Book / Exhibit 3 SuperUser certification / Huibai demo discount agreement / 惠百 PO 盖章版 / Celvivo Distribution Agreement 2026 Huibai Bio / 1331651_20260630_131201 (6-30 quote) / Packing Slip Ordre 726_1 / Packing Slip Ordre 726_2)"). **Structural significance**: the `celvivo_commercial/` directory is new — Robin has migrated the 6-30 quote out of wherever it was previously (presumably a working folder or `05-Documents/Products/Celvivo/` deep path) into a top-level dedicated directory. **The migration is unfinished** — only 1 file in the new directory; if Robin intends the directory to consolidate all 8 commercial docs from `05-Documents/Products/Celvivo/Industrial-Customers/`, the other 7 files (Exhibit 1 Price Book / Exhibit 3 SuperUser certification / Huibai demo discount agreement / 惠百 PO 盖章版 / Celvivo Distribution Agreement 2026 / Packing Slip Ordre 726_1 / Packing Slip Ordre 726_2) should eventually land here too. **No synthesis routes** until Robin commits the file or migrates more docs into the directory. Carry-forward status (2026-08-21): untracked, single-entry, **5-day carry-forward** since first observation (2026-08-17 fetch — was 4-day at the 2026-08-20 fetch), future-commit candidate. Track on next fetch whether (a) the file gets committed, (b) more commercial docs migrate into the directory.
 - **2026-08-15 sources-sync bug — count-data wipe (operational)** — the `2507925e27b83b4f9d2e6f3b9c939d081a90f9f2` `chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-15)` commit at 2026-08-15 +0800 02:31 committed **empty count values** for NocoDB / Wiki.js / RAGFlow (SeaFile was already empty so the commit was a no-op there): (a) NocoDB: 6614 → **0** total records, with all 13 per-table counts (brain_organoid_literature / intestinal_organoid_literature / Celvivo_literature / cardiac_organoid_literature / cancer_organoid_literature / liver_organoid_literature / other_organoid_literature / kidney_organoid_literature / retinal_organoid_literature / Cellink_literature / organoid_literature_old / lung_organoid_literature / 3Brain_literature) cleared to empty cells; (b) SeaFile: libraries table unchanged (was empty in `1737454` already — a separate, older cron issue not introduced by `2507925`); (c) Wiki.js: 83 → **0** unique pages, ID range 22..1704 → **0..0**, Locale 分布 → empty, Top-level 路径分布 → empty; (d) RAGFlow: landing 200 → **000**, `/api/v1/health` 404 → **000**, `/api/v1/datasets` 401 → **000**. The header lines on each affected `/sources/{nocodb,ragflow,seafile,wikijs}.md` page still report `上次同步: 2026-08-14T18:30:42Z` (the prior successful sync timestamp), but the body count values are wiped. **Probable root cause**: the auto-source-sync CRON job ran but the underlying NocoDB / Wiki.js / RAGFlow API calls failed (likely the same operational issue already documented on `/sources/web-search.md` and `/sources/README.md` — runtime registry disagreement on `enabled: true` vs. disabled); the script committed the empty values instead of skipping the commit on failure. **Impact**: 3 source pages now show misleading zero/null values (NocoDB / Wiki.js / RAGFlow); Tavily / HN / git-repo synthesis is unaffected. **Recovery**: the wiped data is recoverable from the prior wiki commit (`git show 1737454:sources/nocodb.md` etc. will restore the pre-wipe state). This run restored the wiped data on all 3 affected pages (plus an operational note documenting the bug) so the wiki is internally consistent again. **Wiki-synthesis concern**: **none** — the synthesis layer (themes / commitments / open-questions / personal-logistics) is independent of the source-page counters. **Operational concern**: **yes** — the auto-source-sync job should (a) check connectivity before committing, (b) skip the commit on API failure rather than committing empty values, or (c) preserve the prior counter values when a fresh pull returns null/empty. Recorded for traceability here + on each affected `/sources/{nocodb,ragflow,seafile,wikijs}.md` page.
 - **Liang 2026 liver organoid fibrosis platform (2026-08-12)** — `04-Literature/Deep-Reads/Liver/2026-08-12_Liang_2026_SciRep_liver_organoid_fibrosis_platform.md` (170 lines; `[[MOC-类器官与3D培养]]` already names this paper via `related:` back-link). The paper is **the net-new external evidence** this run (git-repo-1 2026-08-12) brought into the vault; see synthesis at `/themes/01-organoid-equipment.md` § CelVivo evidence (added 2026-08-12) and `/commitments.md` `liang-2026-celvivo-clinostar-positioning`. Single-paper LDR cycle: 4 commits (`e542c977` → `8699a154` → `aacba7aa` → `297f106d`) walked Robin's standard 3-stage SOP on the same file (186 lines → 105+/122- page 946 rewrite → page 934 修齐 micro-revisions). The 4-star "与我们的产品" table on the paper lists **CelVivo ClinoStar ⭐⭐⭐⭐** (P1-P10 长程扩增对应旋转培养 30+ 天无剪切; HSC 静止态在模拟微重力下 7+ 天维持) + **CelVivo ClinoReactor ⭐⭐⭐⭐** (单组织 3 轨道分通道灌流; TGFβ 时间程序精确切换) — **parallel CelVivo ClinoStar rating 5 to Miao 2025 v2's ClinoStar rating 5** from the 2026-08-08 flywheel-sync, but for liver organoid (long-term maturation + fibrosis modeling) rather than lung organoid (vascularization). 7 SeaFile Fig (Fig1-7) + 4-paper 参考文献 (Huch 2013 / Huch 2015 / Clevers 2016). Customer-entry: 药企临床前 (抗纤维化药筛) + 临床肝活检中心 (1-2 mg → 3 周药敏) + 学术 PI (2D vs 3D 旋转 efficiency). **MOC linkage**: the paper's `related:` field already names `[[MOC-类器官与3D培养]]` (the first MOC, created 2026-08-10) — confirming the MOC pattern is in active use on real deep-reads.
 - **CelVivo industrial customers program** — a dedicated subfolder under
@@ -526,15 +755,413 @@ fields still 待补).
 ## Synthesis policy for this source
- **This run (2026-08-15, git-repo-1 18:07Z):** **0 new vault commits**
+- **This run (2026-08-21, git-repo-1 18:09Z):** **0 new vault commits**
-  in the 2026-08-13T18:08Z → 2026-08-15T18:07Z window — the vault HEAD
+  in the 2026-08-20T18:09Z → 2026-08-21T18:09Z 24-hour window — the
-  is unchanged at `297f106d` across **both** the 2026-08-13 and
+  vault HEAD is **unchanged at `a4fa5a32`** for the **5th consecutive
-  2026-08-15 fetches (the 2026-08-12 Liang 2026 4-commit LDR cluster
+  fetch** (the 2026-08-16 Quintard 2024 Nat Commun 4-commit LDR cycle
-  remains the most recent vault activity). **No new untracked files**
+  + Guo 2026 Front Cell Dev Biol 3-commit LDR cycle remain the most
-  in the 24-hour window — the untracked file set is unchanged from
+  recent vault activity, **5 calendar days stale** at this fetch).
-  the 2026-08-13 fetch (the `Review/zhou2023_computer_vision_microfluidics.md`
+  **0 new vault mtime changes** — the 2 untracked directories
-  first-entry-in-Review/-subfolder is still untracked, carrying
+  (`celvivo_commercial/` + `templates/`) and the 23+ untracked files
-  forward). Wiki-side: **4 new wiki commits** landed (`021e929` daily
+  from the 2026-08-17T18:09Z fetch carry forward unchanged. The
  `Review/zhou2023_computer_vision_microfluidics.md` first-entry in the
  new `Review/` subfolder is **10-day carry-forward** at this fetch
  (uncommitted since 2026-08-11); the structural signal for `Review/`
  continues to weaken per the Notable-entity entry (the subfolder has
  been a single-entry watchlist since 2026-08-13, now **8 fetches
  silent**). Wiki-side: **2 new automated wiki commits** landed in
  the 24-hour window — `b6dc337` chore: daily update 2026-08-21
  (2026-08-21 02:27 +0800) + `f6c2576` chore(sources): refresh
  NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-21,
  2026-08-21 02:30 +0800) — advancing wiki HEAD from `bd30339`
  (2026-08-20T18:09Z fetch) to `f6c2576`. Both commits are routine
  auto-orchestration: (a) the `b6dc337` daily update carried the
  synthesis-layer edits from the prior HN-1 2026-08-21T18:00Z +
  web-search-1 2026-08-21 (skipped) + git-repo-1 2026-08-20T18:09Z
  runs; the `b6dc337` daily update committed `sources/index.md`
  from the 2026-08-20 dirty set (reducing uncommitted-file count
  from 10 → 9 at this fetch); (b) the `f6c2576` sources-sync
  re-applied the count-data wipe pattern on NocoDB / SeaFile /
  Wiki.js / RAGFlow for the **seventh** consecutive sources-sync
  (after 2026-08-15 `2507925` + 2026-08-16 `997b648` + 2026-08-17
  `be49285` + 2026-08-18 `1fc73ae` + 2026-08-19 `dcb53a2` +
  2026-08-20 `bd30339`).
  **No new external evidence** in this run (vault silent), **no
  new theme row**, **no new commitment row**, **no new open-question
  row**, **no new personal-logistics item** — the synthesis layer
  is unchanged. Wiki edits this run: (a) `/sources/git-repo.md` (this
  page) — refreshed frontmatter HEAD pointers (vault HEAD unchanged at
  `a4fa5a32`, wiki HEAD `bd30339` → `f6c2576`, tags + `2026-08-21`,
  timestamp → `2026-08-21T18:09:00Z`), refreshed the Connector /
  State section to the new `2026-08-21T18-08-59-795Z` raw manifest,
  refreshed the obsidian-vault working-tree-status section to
  2026-08-21 (0 new commits, 0 new mtime changes, untracked set
  unchanged; `Review/` 9-day → 10-day + `templates/` + `celvivo_commercial/`
  4-day → 5-day carry-forward), refreshed the openwiki-wiki
  working-tree-status section to 2026-08-21 (2 new automated wiki
  commits + 9 uncommitted synthesis-layer edits, down from 10 because
  `sources/index.md` was committed by `b6dc337`),
  added 2 new entries at the top of the Recent-commits-for-wiki
  table (`f6c2576` sources-sync 2026-08-21 + `b6dc337` daily update
  2026-08-21), refreshed the Summary-of-last-48-hours table to add
  the 2026-08-20T18:09Z → 2026-08-21T18:09Z window data (0 vault
  commits / 2 wiki commits / operational row noting the **seventh**
  consecutive sources-sync re-applying the count-data wipe pattern),
  refreshed the Notable-entity `Review/` entry (9-day → 10-day carry-
  forward, **7 fetches silent** → **8 fetches silent**) + bumped
  `templates/` + `celvivo_commercial/` 4-day → 5-day, refreshed
  the Synthesis-policy section with this run's delta summary;
  (b) `/themes/05-robin-research.md` — vault-snapshot metadata
  refreshed (fetch timestamp → `2026-08-21T18:09:00Z`, raw-manifest path
  → the new `2026-08-21T18-08-59-795Z` manifest); the vault HEAD
  pointer stays `a4fa5a32` (unchanged across the 2026-08-17 +
  2026-08-18 + 2026-08-19 + 2026-08-20 + 2026-08-21 fetches);
  `Review/` 9-day → 10-day carry-forward; `Templates/` +
  `CelVivo-commercial/` 4-day → 5-day; (c) `/quickstart.md` —
  added the "Latest update — git-repo-1 (2026-08-21T18:09Z)"
  paragraph; updated the Backlog git-repo entry to reflect the
  new wiki HEAD `f6c2576` + 2 new automated wiki commits + 9
  uncommitted synthesis-layer edits (down from 10) + the
  **seventh** consecutive sources-sync note; (d) `/sources/README.md`
  — refreshed Active connectors Git repo row + Connector roll Git
  repo row to mention the 2026-08-21 18:09 UTC fetch + the
  **seventh** consecutive sources-sync. **No `/themes.md` row
  change, no `/commitments.md` row, no `/open-questions.md` row,
  no `/personal-logistics.md` item** — the vault delta is empty and
  the wiki delta is automated maintenance only. The "vault is silent
  on a 24-hour window" pattern continues to be normal cadence for
  Robin's workflow (the 2026-08-13 + 2026-08-15 + 2026-08-18 +
  2026-08-19 + 2026-08-20 fetches were also 0-new-vault-commits
  daily-cycle follow-ups; the 2026-08-21 fetch makes it **6
  consecutive 0-new-vault-commit fetches**). The synthesis layer
  (themes / commitments / open-questions / personal-logistics) is
  independent of the wiki-side automated maintenance commits.
 - **Previous run (2026-08-20, git-repo-1 18:09Z):** **0 new vault commits**
  in the 2026-08-19T18:08Z → 2026-08-20T18:09Z 24-hour window — the
  vault HEAD is **unchanged at `a4fa5a32`** for the **4th consecutive
  fetch** (the 2026-08-16 Quintard 2024 Nat Commun 4-commit LDR cycle
  + Guo 2026 Front Cell Dev Biol 3-commit LDR cycle remain the most
  recent vault activity, **4 calendar days stale** at this fetch).
  **0 new vault mtime changes** — the 2 untracked directories
  (`celvivo_commercial/` + `templates/`) and the 23+ untracked files
  from the 2026-08-17T18:09Z fetch carry forward unchanged. The
  `Review/zhou2023_computer_vision_microfluidics.md` first-entry in the
  new `Review/` subfolder is **9-day carry-forward** at this fetch
  (uncommitted since 2026-08-11); the structural signal for `Review/`
  continues to weaken per the Notable-entity entry (the subfolder has
  been a single-entry watchlist since 2026-08-13, now **7 fetches
  silent**). Wiki-side: **2 new automated wiki commits** landed in
  the 24-hour window — `a44f284` chore: daily update 2026-08-20
  (2026-08-20 02:23 +0800) + `bd30339` chore(sources): refresh
  NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-20,
  2026-08-20 02:30 +0800) — advancing wiki HEAD from `dcb53a2`
  (2026-08-19T18:08Z fetch) to `bd30339`. Both commits are routine
  auto-orchestration: (a) the `a44f284` daily update carried the
  synthesis-layer edits from the prior HN-1 2026-08-20T18:00Z +
  web-search-1 2026-08-20 (skipped) + git-repo-1 2026-08-19T18:08Z
  runs; (b) the `bd30339` sources-sync re-applied the count-data wipe
  pattern on NocoDB / SeaFile / Wiki.js / RAGFlow for the **sixth**
  consecutive sources-sync (after 2026-08-15 `2507925` + 2026-08-16
  `997b648` + 2026-08-17 `be49285` + 2026-08-18 `1fc73ae` +
  2026-08-19 `dcb53a2`).
  **No new external evidence** in this run (vault silent), **no
  new theme row**, **no new commitment row**, **no new open-question
  row**, **no new personal-logistics item** — the synthesis layer
  is unchanged. Wiki edits this run: (a) `/sources/git-repo.md` (this
  page) — refreshed frontmatter HEAD pointers (vault HEAD unchanged at
  `a4fa5a32`, wiki HEAD `dcb53a2` → `bd30339`, tags + `2026-08-20`,
  timestamp → `2026-08-20T18:09:15Z`), refreshed the Connector /
  State section to the new `2026-08-20T18-09-15-122Z` raw manifest,
  refreshed the obsidian-vault working-tree-status section to
  2026-08-20 (0 new commits, 0 new mtime changes, untracked set
  unchanged; `Review/` 8-day → 9-day + `templates/` + `celvivo_commercial/`
  3-day → 4-day carry-forward), refreshed the openwiki-wiki
  working-tree-status section to 2026-08-20 (2 new automated wiki
  commits + the carry-forward 10 uncommitted synthesis-layer edits),
  added 2 new entries at the top of the Recent-commits-for-wiki
  table (`bd30339` sources-sync 2026-08-20 + `a44f284` daily update
  2026-08-20), refreshed the Summary-of-last-48-hours table to add
  the 2026-08-19T18:08Z → 2026-08-20T18:09Z window data (0 vault
  commits / 2 wiki commits / operational row noting the **sixth**
  consecutive sources-sync re-applying the count-data wipe pattern),
  refreshed the Notable-entity `Review/` entry (8-day → 9-day carry-
  forward, **6 fetches silent** → **7 fetches silent**) + bumped
  `templates/` + `celvivo_commercial/` 3-day → 4-day, refreshed
  the Synthesis-policy section with this run's delta summary;
  (b) `/themes/05-robin-research.md` — vault-snapshot metadata
  refreshed (fetch timestamp → `2026-08-20T18:09:15Z`, raw-manifest path
  → the new `2026-08-20T18-09-15-122Z` manifest); the vault HEAD
  pointer stays `a4fa5a32` (unchanged across the 2026-08-17 +
  2026-08-18 + 2026-08-19 + 2026-08-20 fetches); `Review/`
  8-day → 9-day carry-forward; `Templates/` + `CelVivo-commercial/`
  3-day → 4-day; (c) `/quickstart.md` — added the "Latest update
  — git-repo-1 (2026-08-20T18:09Z)" paragraph; updated the Backlog
  git-repo entry to reflect the new wiki HEAD `bd30339` + 2 new
  automated wiki commits + the carry-forward 10 uncommitted files +
  the **sixth** consecutive sources-sync note; (d) `/sources/README.md`
  — refreshed Active connectors Git repo row + Connector roll Git
  repo row to mention the 2026-08-20 18:09 UTC fetch + the **sixth**
  consecutive sources-sync. **No `/themes.md` row change, no
  `/commitments.md` row, no `/open-questions.md` row, no
  `/personal-logistics.md` item** — the vault delta is empty and the
  wiki delta is automated maintenance only. The "vault is silent on
  a 24-hour window" pattern continues to be normal cadence for Robin's
  workflow (the 2026-08-13 + 2026-08-15 + 2026-08-18 + 2026-08-19
  fetches were also 0-new-vault-commits daily-cycle follow-ups; the
  2026-08-20 fetch makes it **5 consecutive 0-new-vault-commit
  fetches**). The synthesis layer (themes / commitments /
  open-questions / personal-logistics) is independent of the wiki-side
  automated maintenance commits.
 - **Previous run (2026-08-19, git-repo-1 18:08Z):** **0 new vault commits**
  in the 2026-08-18T18:10Z → 2026-08-19T18:08Z 24-hour window — the
  vault HEAD is **unchanged at `a4fa5a32`** for the **3rd consecutive
  fetch** (the 2026-08-16 Quintard 2024 Nat Commun 4-commit LDR cycle
  + Guo 2026 Front Cell Dev Biol 3-commit LDR cycle remain the most
  recent vault activity, **3 calendar days stale** at this fetch).
  **0 new vault mtime changes** — the 2 untracked directories
  (`celvivo_commercial/` + `templates/`) and the 23+ untracked files
  from the 2026-08-17T18:09Z fetch carry forward unchanged. The
  `Review/zhou2023_computer_vision_microfluidics.md` first-entry in the
  new `Review/` subfolder is **8-day carry-forward** at this fetch
  (uncommitted since 2026-08-11); the structural signal for `Review/`
  continues to weaken per the Notable-entity entry (the subfolder has
  been a single-entry watchlist since 2026-08-13, now **6 fetches
  silent**). Wiki-side: **2 new automated wiki commits** landed in
  the 24-hour window — `7e904ec` chore: daily update 2026-08-19
  (2026-08-19 02:23 +0800) + `dcb53a2` chore(sources): refresh
  NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-19,
  2026-08-19 02:30 +0800) — advancing wiki HEAD from `1fc73ae`
  (2026-08-18T18:10Z fetch) to `dcb53a2`. Both commits are routine
  auto-orchestration: (a) the `7e904ec` daily update carried the
  synthesis-layer edits from the prior HN-1 2026-08-19T18:00Z +
  web-search-1 2026-08-19 + git-repo-1 2026-08-18T18:10Z runs
  (touching `.last-update.json` + `quickstart.md` +
  `sources/{README,git-repo,hackernews,index,nocodb,ragflow,seafile,web-search,wikijs}.md`
  + `themes/05-robin-research.md` per `git show --stat 7e904ec`);
  (b) the `dcb53a2` sources-sync re-applied the count-data wipe
  pattern on NocoDB / SeaFile / Wiki.js / RAGFlow for the **fifth**
  consecutive sources-sync (after 2026-08-15 `2507925` + 2026-08-16
  `997b648` + 2026-08-17 `be49285` + 2026-08-18 `1fc73ae`).
  **No new external evidence** in this run (vault silent), **no
  new theme row**, **no new commitment row**, **no new open-question
  row**, **no new personal-logistics item** — the synthesis layer
  is unchanged. Wiki edits this run: (a) `/sources/git-repo.md` (this
  page) — refreshed frontmatter HEAD pointers (vault HEAD unchanged at
  `a4fa5a32`, wiki HEAD `1fc73ae` → `dcb53a2`, tags + `2026-08-19`,
  timestamp → `2026-08-19T18:08:24Z`), refreshed the Connector /
  State section to the new `2026-08-19T18-08-24-164Z` raw manifest,
  refreshed the obsidian-vault working-tree-status section to
  2026-08-19 (0 new commits, 0 new mtime changes, untracked set
  unchanged), refreshed the openwiki-wiki working-tree-status section
  to 2026-08-19 (2 new automated wiki commits + the carry-forward 10
  uncommitted synthesis-layer edits — `sources/index.md` re-appears
  as dirty in the working tree at this fetch), added 2 new entries at
  the top of the Recent-commits-for-wiki table (`dcb53a2` +
  `7e904ec`), refreshed the Summary-of-last-48-hours table to add the
  2026-08-18T18:10Z → 2026-08-19T18:08Z window data (0 vault commits /
  2 wiki commits / operational row noting the **fifth** consecutive
  sources-sync re-applying the count-data wipe pattern), refreshed
  the Synthesis-policy section with this run's delta summary; (b)
  `/themes/05-robin-research.md` — vault-snapshot metadata refreshed
  (fetch timestamp → `2026-08-19T18:08:24Z`, raw-manifest path → the
  new `2026-08-19T18-08-24-164Z` manifest); the vault HEAD pointer
  stays `a4fa5a32` (unchanged across the 2026-08-17 + 2026-08-18 +
  2026-08-19 fetches); (c) `/quickstart.md` — added the "Latest update
  — git-repo-1 (2026-08-19T18:08Z)" paragraph; updated the Backlog
  git-repo entry to reflect the new wiki HEAD `dcb53a2` + 2 new
  automated wiki commits + the carry-forward 10 uncommitted files +
  the **fifth** consecutive sources-sync note. **No `/themes.md` row
  change, no `/commitments.md` row, no `/open-questions.md` row, no
  `/personal-logistics.md` item** — the vault delta is empty and the
  wiki delta is automated maintenance only. The "vault is silent on
  a 24-hour window" pattern continues to be normal cadence for Robin's
  workflow (the 2026-08-13 + 2026-08-15 + 2026-08-18 fetches were
  also 0-new-vault-commits daily-cycle follow-ups; the 2026-08-19
  fetch made it **4 consecutive 0-new-vault-commit fetches**).
  The synthesis layer (themes / commitments / open-questions /
  personal-logistics) is independent of the wiki-side automated
  maintenance commits.
 - **Previous run (2026-08-18, git-repo-1 18:10Z):** **0 new vault commits**
  in the 2026-08-17T18:09Z → 2026-08-18T18:10Z 24-hour window — the
  vault HEAD is **unchanged at `a4fa5a32`** (the 2026-08-16 Quintard
  2024 Nat Commun 4-commit LDR cycle + Guo 2026 Front Cell Dev Biol
  3-commit LDR cycle remain the most recent vault activity, 2 calendar
  days stale at this fetch). **0 new vault mtime changes** — the 2
  untracked directories (`celvivo_commercial/` + `templates/`) and the
  23+ untracked files from the 2026-08-17T18:09Z fetch carry forward
  unchanged. The `Review/zhou2023_computer_vision_microfluidics.md`
  first-entry in the new `Review/` subfolder is **7-day carry-forward**
  at this fetch (uncommitted since 2026-08-11); the structural signal
  for `Review/` continues to weaken per the Notable-entity entry (the
  subfolder has been a single-entry watchlist since 2026-08-13).
  Wiki-side: **2 new automated wiki commits** landed in the 24-hour
  window — `8127797` chore: daily update 2026-08-18 (2026-08-18
  02:23 +0800) + `1fc73ae` chore(sources): refresh
  NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-18,
  2026-08-18 02:30 +0800) — advancing wiki HEAD from `be49285`
  (2026-08-17T18:09Z fetch) to `1fc73ae`. Both commits are routine
  auto-orchestration: (a) the `8127797` daily update carried the
  synthesis-layer edits from the prior HN-1 2026-08-18T18:00Z run +
  this git-repo-1 2026-08-17T18:09Z run (touching `commitments.md` +
  `index.md` + `quickstart.md` + `sources/{README,git-repo,hackernews,index,literature,nocodb,ragflow,seafile,web-search,wikijs}.md`
  + `themes/{01-organoid-equipment,05-robin-research}.md` per
  `git show --stat 8127797`); (b) the `1fc73ae` sources-sync
  re-applied the count-data wipe pattern on NocoDB / SeaFile / Wiki.js
  / RAGFlow for the **fourth** consecutive sources-sync (after
  2026-08-15 `2507925` + 2026-08-16 `997b648` + 2026-08-17 `be49285`).
  **No new external evidence** in this run (vault silent), **no
  new theme row**, **no new commitment row**, **no new open-question
  row**, **no new personal-logistics item** — the synthesis layer
  is unchanged. Wiki edits this run: (a) `/sources/git-repo.md` (this
  page) — refreshed frontmatter HEAD pointers (vault HEAD unchanged at
  `a4fa5a32`, wiki HEAD `be49285` → `1fc73ae`, tags + `2026-08-18`,
  timestamp → `2026-08-18T18:10:12Z`), refreshed the Connector /
  State section to the new `2026-08-18T18-10-12-916Z` raw manifest,
  refreshed the obsidian-vault working-tree-status section to
  2026-08-18 (0 new commits, 0 new mtime changes, untracked set
  unchanged), refreshed the openwiki-wiki working-tree-status section
  to 2026-08-18 (2 new automated wiki commits + the carry-forward 9
  uncommitted synthesis-layer edits), added 2 new entries at the top
  of the Recent-commits-for-wiki table (`1fc73ae` + `8127797`),
  refreshed the Summary-of-last-48-hours table to add the
  2026-08-17T18:09Z → 2026-08-18T18:10Z window data (0 vault commits /
  2 wiki commits / operational row noting the **fourth** consecutive
  sources-sync re-applying the count-data wipe pattern), refreshed
  the Synthesis-policy section with this run's delta summary; (b)
  `/themes/05-robin-research.md` — vault-snapshot metadata refreshed
  (fetch timestamp → `2026-08-18T18:10:12Z`, raw-manifest path → the
  new `2026-08-18T18-10-12-916Z` manifest); the vault HEAD pointer
  stays `a4fa5a32` (unchanged across both 2026-08-17 and 2026-08-18
  fetches); (c) `/quickstart.md` — added the "Latest update —
  git-repo-1 (2026-08-18T18:10Z)" paragraph; updated the Backlog
  git-repo entry to reflect the new wiki HEAD `1fc73ae` + 2 new
  automated wiki commits + the carry-forward 9 uncommitted files +
  the **fourth** consecutive sources-sync note. **No `/themes.md` row
  change, no `/commitments.md` row, no `/open-questions.md` row, no
  `/personal-logistics.md` item** — the vault delta is empty and the
  wiki delta is automated maintenance only. The "vault is silent on
  a 24-hour window" pattern continues to be normal cadence for Robin's
  workflow (the 2026-08-13 fetch was also a 0-new-vault-commits
  daily-cycle follow-up; the 2026-08-15 fetch was also a 0-new-vault-
  commits daily-cycle follow-up). The synthesis layer (themes /
  commitments / open-questions / personal-logistics) is independent
  of the wiki-side automated maintenance commits.
 - **Previous run (2026-08-17, git-repo-1 18:09Z):** **7 new vault commits**
  landed in the 2026-08-15T18:07Z → 2026-08-17T18:09Z window — the vault
  HEAD bumped from `297f106d` (the 2026-08-12 Liang 2026 cluster) to
  `a4fa5a32` (the 2026-08-16 Quintard 2024 + Guo 2026 cluster). The
  cluster breaks down as: (a) **Quintard 2024 Nat Commun 4-commit LDR
  cycle** (`0fc8db24` adds 189 lines → `290e9635` -v2 修图床/双 H1/落款
  → `24c713de` -v3 Wiki.js 自带图床 6 张图 → `4073abf4` -v4 转发语标题/
  落款加粗/删 3Brain) on `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md`;
  (b) **Guo 2026 Front Cell Dev Biol 3-commit LDR cycle** (`2e6f5989`
  adds 170 lines → `00f824f2` -v2 修图床 (加 2 张 Wiki.js 自带图) →
  `a4fa5a32` -v3 补 Fig 1) on
  `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md`.
  The 2026-08-16 cluster is **the first time since the 2026-07-28 /
  2026-07-29 Parate / Lee / Hodge cluster** that two new paper deep-reads
  landed on `main` in the same 48-hour window, and **the first time a
  review-type IRB / ethics systematic review (Guo 2026) was deep-read**
  in any vault window. **2 new untracked directories** appeared in
  the working tree this fetch: (a) `celvivo_commercial/1331651_20260630_131201.pdf`
  (the 6-30 quote PDF migrated into a new folder); (b) `templates/类器官IRB申请清单.md`
  (the IRB application checklist Robin produced from the Guo 2026
  review — Robin's **first customer-facing sales ammunition template**
  derived from a single deep-read). The 23 untracked working-tree
  files from the 2026-08-13 fetch are unchanged at this fetch (the
  `Review/zhou2023_computer_vision_microfluidics.md` first-entry-in-Review/-subfolder
  is still untracked, now a **4-day carry-forward** with watchlist
  signal weakening per the Notable-entity entry). Wiki-side: **4 new
  wiki commits** landed (`151d22b` daily update 2026-08-16 +
  `997b648` sources-sync 2026-08-16 + `5c70881` daily update 2026-08-17
  (created the new `sources/openwiki-version-drift.md` auto-generated
  page) + `be49285` sources-sync 2026-08-17), advancing HEAD from
  `2507925` (2026-08-15) to `be49285` (2026-08-17). 9 dirty wiki files
  in the working tree (`.last-update.json` + `quickstart.md` +
  `sources/README.md` + `sources/hackernews.md` + `sources/nocodb.md`
  + `sources/ragflow.md` + `sources/seafile.md` + `sources/web-search.md`
  + `sources/wikijs.md`) are **accumulated** synthesis-layer edits
  from the prior HN-1 2026-08-15 + HN-1 2026-08-16 + HN-1 2026-08-17 +
  web-search-1 2026-08-15 + web-search-1 2026-08-17 + git-repo-1
  2026-08-15 runs that are pending the next CLI orchestration commit
  (down from 10 dirty files at the 2026-08-15 fetch — `sources/index.md`
  got committed in the `151d22b` 2026-08-16 daily update). One
  **new wiki file** added in the window: `sources/openwiki-version-drift.md`
  (auto-generated OpenWiki version drift monitor; reports `v0.3.1` local
  → `v0.3.3` npm latest as of 2026-08-15T20:00:03Z with a manual
  `npm install -g openwiki@latest` action and a WARNING that v0.3.1 →
  v0.4+ may have breaking changes; the page is informational, not a
  synthesis target). **No `/commitments.md` row, no
  `/open-questions.md` row, no `/personal-logistics.md` item**
  added this run beyond the canonical synthesis pipeline — the
  Quintard 2024 deep-read has no existing synthesis page yet (the
  deep-read pipeline currently only carries `liang-2026-celvivo-clinostar-positioning`
  + `miao-2025-celvivo-clinostar-positioning` + `liu-2026-hd-mea-roadmap-implication`
  + `sharma-2026-retinal-organoid-mea-cross-sell`); the Guo 2026 IRB
  review is the first ethics-side deep-read and the IRB checklist
  template is the first customer-facing sales ammunition template,
  both of which warrant a commitment + a synthesis page on a future
  fetch. Wiki edits this run: (a) `/sources/git-repo.md` (this page)
  — refreshed frontmatter HEAD pointers (vault HEAD `297f106d` →
  `a4fa5a32`, wiki HEAD `2507925` → `be49285`, tags + `2026-08-17`,
  timestamp → `2026-08-17T18:09:32Z`), refreshed the Connector / State
  section to the new `2026-08-17T18-09-32-895Z` raw manifest, refreshed
  the obsidian-vault working-tree-status section to 2026-08-17 (7 new
  vault commits, 2 new untracked dirs, the `Review/zhou2023_computer_vision_microfluidics.md`
  carries forward as still-untracked), refreshed the
  Recent-commits-for-vault table to put the 7 new 2026-08-16 commits
  on top of the 2026-08-12 cluster, refreshed the openwiki-wiki
  working-tree-status section to 2026-08-17 (4 new wiki commits + 9
  uncommitted synthesis-layer edits — `sources/index.md` got committed
  in `151d22b`), refreshed the Recent-commits-for-wiki table to put
  the 4 new 2026-08-16/2026-08-17 commits on top of the 2026-08-15
  cluster, refreshed the Summary-of-last-48-hours table to add the
  2026-08-15T18:07Z → 2026-08-17T18:09Z window data (7 vault commits /
  4 wiki commits / 9 uncommitted wiki files / 1 new wiki file +
  2 new untracked dirs + 4-day carry-forward on `Review/` subfolder),
  refreshed the Notable-entity section to add (a) "Quintard 2024
  microfluidic vascularized organoid chip" entry (with 4-star
  Mimetas/CelVivo/Emulate mapping), (b) "Guo 2026 organoid ethics
  systematic review" entry (with 4-star Mimetas/CelVivo/Emulate
  mapping + IRB checklist template cross-link), (c) refreshed
  "Review/ subfolder" entry with watchlist-trigger-met note, (d)
  new "templates/ subfolder" entry (first customer-facing sales
  ammunition template), (e) new "celvivo_commercial/ subfolder" entry
  (the 6-30 quote PDF migration), refreshed the Synthesis-policy
  section with this run's delta summary. **No `/themes.md` row change**
  — the new external evidence routes into the existing
  `class-organoid-3d-bioprinting` theme row (Quintard 2024 is
  organ-on-chip adjacent to Robin's 4 application domains; Guo 2026
  is IRB-side adjacent to the same row); the Robin-authored
  IRB checklist template routes into the existing
  `/themes/05-robin-research.md` "Sales ammunition pipeline" section
  rather than a new theme row. **No `/open-questions.md` row, no
  `/personal-logistics.md` item** — the IRB checklist is a
  vendor-anchored customer-training artifact, not a memory-graph
  uncertainty. (b) `/themes/05-robin-research.md` — vault-snapshot
  metadata refreshed (fetch timestamp → `2026-08-17T18:09:32Z`,
  raw-manifest path → the new `2026-08-17T18-09-32-895Z` manifest;
  vault HEAD `297f106d` → `a4fa5a32`; untracked-dir set refreshed
  with `celvivo_commercial/` + `templates/` entries; `04-Literature/Deep-Reads/Organoid/`
  count `659` → `661` (Quintard + Guo); 30-day research output
  table extended with the 2026-08-16 Quintard 2024 + Guo 2026 row;
  by-vendor table extended with `Microfluidic / organ-on-chip
  adjacent` and `Ethics / IRB` rows; Sales ammunition pipeline section
  extended with the `templates/类器官IRB申请清单.md` IRB checklist
  template). (c) `/themes/01-organoid-equipment.md` — Quintard 2024
  added to CelVivo evidence anchors (CelVivo ClinoStar rating 3
  upstream workflow step) and Guo 2026 added to the Regulatory /
  China-specific context section (CelVivo ClinoStar rating 4 IRB
  compliance ammunition; companion to the existing CDE classification
  + Order No. 818 items). (d) `/sources/literature.md` — Quintard 2024
  + Guo 2026 added to the 30-day deep-read index. (e) `/sources/README.md`
  — git-repo last-updated refreshed from `2026-08-15 18:07 UTC` to
  `2026-08-17 18:09 UTC`. (f) `/quickstart.md` — added the
  "Latest update — git-repo-1 (2026-08-17T18:09Z)" paragraph. Wiki-side: **4 new wiki commits** landed (`021e929` daily
  update 2026-08-14 + `6258717` sources-sync 2026-08-14 + `173b58c`
  daily update 2026-08-15 + `2507925` sources-sync 2026-08-15),
  advancing HEAD from `1737454` (2026-08-13) to `2507925` (2026-08-15).
@@ -644,3 +1271,4 @@ fields still 待补).
 Run `openwiki_ingest_connector connectorId=git-repo` (or
 `openwiki personal --update`) to refresh. Expect HEAD bump, refreshed
 `recentCommits`, and updated working-tree status.
 rking-tree status.
@@ -4,7 +4,7 @@
 - [Agents 代理商档案索引 — 跨 agent CRM 同步](agents.md) - Cross-agent index of the Obsidian vault 02-Clients/Agents/* profiles (which agents Robin is actively working with, mapped by vendor product line). Base identity only — sensitive fields (phone / WeChat / email / end-customer list / opportunity value) live only in the private vault. Updated 2026-08-07 with _known_associations.md product-line → agent → end-customer mapping.
 - [全国经销商地图 (2026-08-07 时点)](distributors-china-2026.md) - Compact index of Robin's 2026-08-07 China distributor baseline (259 dealers across 7 regions, replacing 261 in the 2026-07-24 baseline) plus the new product-association index _known_associations.md. Surfaces CelVivo ClinoStar → 济南成全 + FemtoBiomed CellShot → 9X Bio → TriArm Therapeutics chain. Routes pricing-sensitive fields to the private Obsidian vault per /sources/agents.md privacy rule.
 - [飞书邮箱 (Robin customer mailbox)](feishu-mail.md) - Planned cross-agent mailbox sync target for Robin's Feishu (飞书) mailbox (imap.feishu.cn:993 / imap.larksuite.com:993) — would let MiniMax code / Hermes recall 'what did Robin last discuss with customer X' from email metadata + summaries. Not yet provisioned — IMAP credentials + update script + crontab still pending Robin setup; this page documents the planned configuration and the sync policy that will be applied once provisioned.
- [Git repo — evidence index (Obsidian vault, Robin)](git-repo.md) - Compact manifest of Robin's Obsidian vault + the local OpenWiki wiki, ingested through the local git-repo connector. Two configured repos: obsidian-vault at /home/ldw/workspace (main branch, HEAD 297f106d, 2026-08-12, unchanged across the 2026-08-13 / 2026-08-15 fetches) and openwiki-wiki at /home/ldw/.openwiki/wiki (main branch, HEAD 2507925, 2026-08-15). This page is a navigation index — content ingestion (paper deep reads, sales scripts, customer files) happens via the Hermes skill and RAGFlow, not here.
+- [Git repo — evidence index (Obsidian vault, Robin)](git-repo.md) - Compact manifest of Robin's Obsidian vault + the local OpenWiki wiki, ingested through the local git-repo connector. Two configured repos: obsidian-vault at /home/ldw/workspace (main branch, HEAD a4fa5a32, 2026-08-16, **0 new vault commits in the 2026-08-20T18:09Z → 2026-08-21T18:09Z 24-hour window — vault is silent for the 5th consecutive fetch after the 2026-08-16 Quintard + Guo cluster, 5 calendar days stale**) and openwiki-wiki at /home/ldw/.openwiki/wiki (main branch, HEAD f6c2576, 2026-08-21, **2 new automated wiki commits in the 2026-08-20T18:09Z → 2026-08-21T18:09Z window: `b6dc337` daily update 2026-08-21 + `f6c2576` sources-sync 2026-08-21 — the seventh consecutive sources-sync re-applying the 2026-08-15 count-data wipe pattern**). This page is a navigation index — content ingestion (paper deep reads, sales scripts, customer files) happens via the Hermes skill and RAGFlow, not here.
 - [Hacker News — evidence index](hackernews.md) - Compact evidence trail for the Hacker News connector (hackernews-1, Robin-curated life-sciences + AI workflow). Synthesis lives on /themes.md, /commitments.md, etc.; this page only records ingestion coverage and notable items.
 - [文献精读 Master Template (Robin 7-27 实战版, "真适合浏览" 1 文件)](ldr-report-template.md) - Master template for Robin's literature-deep-read (LDR) pipeline — consolidates 4 literature skills (`literature-deep-read` / `research` / `review` / `curation-for-sales`) into a single 8-rule + 3-trigger + 5-section "真适合浏览" report format. Synthesized from 4-27 SOP范本 + 7-27 实战 lessons (Tasevska / Raji / Bosnjakovic). Triggers "精读吧" / "发 wikijs" / "入库" / "A" / Id/DOI/PMID/PDF signals into 4-step精简 or 8-step完整 flows. PDF全文必传 + PyMuPDF xref去重 + 9项强制 + SeaFile hostname `fb.biokingdom.top` + NocoDB v1 JSON + 3张真图 + `journal-year-topic` 报告路径.
 - [Bosnjakovic 2025 PAH 3D 球体代谢组学: 跟 CelVivo ClinoStar dynamic culture 关系 (Bosnjakovic 2025 bioRxiv)](literature-cel-bosnjakovic-2025-pah-deepread.md) - Deep-read synthesis of Bosnjakovic A et al. 2025 bioRxiv preprint (DOI 10.1101/2025.07.10.663939v1, 2025-07-10) — 21-day mature HepG2 3D spheroids with graded non-cytotoxic BaP + BBF (PAH代表物) exposure for metabolomics biomarker discovery. Robin's connection: 3D spheroid protocol maps directly onto CelVivo ClinoStar dynamic culture; supports PAH exposure metabolomics positioning for hepatotoxicity / NAFLD modeling applications. 精读 2026-07-27.
@@ -14,8 +14,9 @@
 - [Raji 2026 (hMOs + 3Brain HD-MEA) — 7-27 增补版 (跟 7-01 矩阵集成)](literature-raji-2026-deepread.md) - Deep-read synthesis of Raji H, Bertoli F, Perez MJ, Lam A, Volpicelli-Daley LA, Deleidi M. 2026 Molecular Psychiatry (Nature 子刊, s41380-026-03667-4, DOI 10.1038/s41380-026-03667-4, IF 11) — human midbrain organoids (hMOs) with WNT modulation, dopaminergic neuron differentiation, bioreactor culture, and 3Brain HD-MEA electrophysiology for Parkinson's disease modeling. 7-01 实战范本 (page 1622) + 7-27 增补版 integrated with 3-paper 3Brain MEA matrix (Raji / Pali / Wei) and 4 product-line complementarity chain (CelVivo ClinoStar + Cellink BIO X + 3Brain HD-MEA + FemtoBiomed CellShot).
 - [Sharma 2026 — vascularized retinal organoid RGC survival and maturation (Cell Stem Cell)](literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md) - Deep-read synthesis of Sharma K et al. (2026) Cell Stem Cell — transiently vascularized human retinal organoids with RGC 18.2% vs ctrl-RO 1.21% at week 18, W31 ON/OFF/ON-OFF light responses, C3 endothelial monolayer integration strategy.
 - [3D 打印缓释 HCTZ 片: 跟 Cellink BIO X 挤出打印 (Tasevska 2025 EJPS)](literature-tasevska-2025-deepread.md) - Deep-read synthesis of Tasevska T et al. 2025 European Journal of Pharmaceutical Sciences 206:106998 (DOI 10.1016/j.ejps.2024.106998, 精读 2026-07-27) — first systematic SSE semi-solid extrusion vs DLP digital-light-processing comparison for sustained-release HCTZ (hydrochlorothiazide) tablets, with focus on SSE matching Cellink BIO X extrusion principle. Supports Robin's 3D-printed personalized-dose / sustained-release positioning and SSE extruder cross-sell narrative for Cellink BIO X accounts.
- [Literature Deep-Reads — cross-agent deep-read index](literature.md) - Cross-agent index of Robin's literature deep-reads across the 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed) and adjacent application domains. Backed by the Obsidian vault 04-Literature/Deep-Reads/ and the flywheel-sync pipeline; synthesis pages are linked per paper.
+- [Literature Deep-Reads — cross-agent deep-read index](literature.md) - Cross-agent index of Robin's literature deep-reads across the 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed) and adjacent application domains (organoid IRB / ethics, vascularized organoids, microfluidic / organ-on-chip). Backed by the Obsidian vault 04-Literature/Deep-Reads/ and the flywheel-sync pipeline; synthesis pages are linked per paper.
 - [NocoDB 文献库索引 — 跨 agent 数据层](nocodb.md)
 - [OpenWiki Upgrade Drift (auto-generated)](openwiki-version-drift.md)
 - [OpenWiki 速查手册 (Robin 一次聊清, 直接拿来用)](OpenWiki%E9%80%9F%E6%9F%A5%E6%89%8B%E5%86%8C.md) - Compact OpenWiki cheat-sheet that condenses the 2026-07-27 6-conversation walkthrough into a single ready-to-share document. Designed for one-shot delivery to any agent / colleague / customer / manager who asks 'what is OpenWiki?' — covers the core concept, structure, sync model, and 4 active connectors in one page.
 - [RAGFlow 文档采样索引](ragflow-documents.md) - Document-level sample index of Robin's RAGFlow instance (http://10.10.10.254:9980) — 18 KBs / 32709 total docs / 401 sample entries (last sync 2026-08-03). Captures the 30-doc-per-request server-side limit + offset bug that forces 12 large KBs to single-page samples. Lets MiniMax code / Hermes see 'what's in each KB' without SQL queries; complements `/sources/ragflow.md` (KB-level health + counts).
 - [RAGFlow 全文检索索引 (Robin KB system)](ragflow.md)
@@ -1,7 +1,7 @@
 ---
 type: "Reference"
 title: "Literature Deep-Reads — cross-agent deep-read index"
-description: "Cross-agent index of Robin's literature deep-reads across the 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed) and adjacent application domains. Backed by the Obsidian vault 04-Literature/Deep-Reads/ and the flywheel-sync pipeline; synthesis pages are linked per paper."
+description: "Cross-agent index of Robin's literature deep-reads across the 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed) and adjacent application domains (organoid IRB / ethics, vascularized organoids, microfluidic / organ-on-chip). Backed by the Obsidian vault 04-Literature/Deep-Reads/ and the flywheel-sync pipeline; synthesis pages are linked per paper."
 tags: [literature, deep-read, flywheel, celvivo, 3brain, cellink, femtobiomed]
 ---
@@ -13,6 +13,13 @@ tags: [literature, deep-read, flywheel, celvivo, 3brain, cellink, femtobiomed]
 ## Last 30 days of deep reads (mtime descending)
 ### 2026-08-16 (Quintard 2024 + Guo 2026 — 2 papers on the same day)
 | DOI | Vendor | Application | Title (short) | Vault path |
 | --- | --- | --- | --- | --- |
 | `10.1038/s41467-024-45710-4` | CelVivo (ClinoStar rating 3 upstream) + Mimetas OrganoPlate (rating 4 direct) + Emulate Organ-Chip (rating 3) | Microfluidic platform for vascularized organoids | Quintard C et al. (2024) A microfluidic platform integrating functional vascularized organoids-on-chip (Nat Commun; 10 通道并行微流控芯片 + U 型捕获位 + hiPSC-BVO 30 天功能性灌注培养 + 跨类器官验证 [间充质球体 / BVO / 胰岛球体 / 肺类器官]; 血管层级化 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管, 壁剪切 27-2000 s⁻¹ 完美匹配人体毛细血管生理范围 50-1900 s⁻¹) — Wiki.js IDs 1719/1720/1722, NocoDB Id 3297; 4-commit LDR cycle 2026-08-16 (`0fc8db24` → `290e9635` → `24c713de` → `4073abf4`); last commit deleted the 3Brain reference per the SOP "硬门槛合规修正" cleanup rule | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` |
 | `10.3389/fcell.2026.1721946` | CelVivo (ClinoStar rating 4 clinical-translation IRB) + Mimetas OrganoPlate (rating 4 co-culture ethics) + Emulate Organ-Chip (rating 3) | Organoid research IRB / ethics systematic review | Guo Z & Zhang N (2026) Ethical review key considerations for organoid applications in biomedical research—a systematic review (Front Cell Dev Biol; 嘉兴市第一医院 + 嘉兴大学医学院视角; 类器官研究 IRB / 伦理审查 7 大强制要点系统综述 [样本来源/知情同意/数据隐私/共培养主体性/3R 动物福利/跨境监管/长期保存与终止使用] + 5 国对照 [中国《人类遗传资源管理条例》+《涉及人的生命科学和医学研究伦理审查办法》2023 / 美国 HIPAA + Common Rule + NIH GDS / 欧盟 GDPR + Clinical Trials Regulation 536/2014 / 日本 / 韩国]) — Wiki.js ID 1724, NocoDB Id 3298; 3-commit LDR cycle 2026-08-16 (`2e6f5989` → `00f824f2` → `a4fa5a32`); Robin translated the paper into a customer-facing IRB application checklist template at `templates/类器官IRB申请清单.md` v1.0 (180 lines; 7 mandatory points + 5 customer Q&A + China vs International flow + 10 attachments + 7 citations) | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` |
 ### 2026-08-09
 | DOI | Vendor | Application | Title (short) | Vault path |
@@ -1,15 +1,9 @@
 ---
 type: "Reference"
 title: "NocoDB 文献库索引 — 跨 agent 数据层"
 openwiki_generated: true
 ---
 # NocoDB 文献库索引 — 跨 agent 数据层
 > 数据源: NocoDB 13 个文献库 + 2 个公司库 (实时,每次 OpenWiki cron 跑时更新)
 > 用途: MiniMax code / Hermes 跨 agent 问 "Robin 的 NocoDB 里有什么"
 > 更新: 自动（`~/.openwiki/update-sources.sh` 每天 02:30 拉一次,数据写入本页后 commit + push Gitea）
-> 上次同步: **2026-08-12T18:30:03Z** · **总记录数: 6614**
+> 上次同步: **2026-08-21T18:30:02Z** · **总记录数: 6620**
 ## 13 个文献库 (实测计数)
@@ -25,7 +19,7 @@ openwiki_generated: true
 | `m8abmmwrgchr9ni` | kidney_organoid_literature | 23 |
 | `mun191tsudjdtga` | retinal_organoid_literature | 4 |
 | `m65htyq25vmpysq` | Cellink_literature | 2499 |
-| `mri6u97xrxi0vvm` | organoid_literature (old) | 2780 |
+| `mri6u97xrxi0vvm` | organoid_literature (old) | 2786 |
 | `mr8wrky2um6gwev` | lung_organoid_literature | 48 |
 | `m76t4vsfar89w0h` | 3Brain_literature | 147 |
@@ -42,7 +36,3 @@ openwiki_generated: true
 - 自动触发: `~/.local/bin/openwiki-update-sources.sh` (每天 02:30 触发)
 - 手动触发: `bash ~/.local/bin/openwiki-update-sources.sh`
 - 数据格式: 跟 `openclaw-imports/nocodb` skill 共用
 ## 操作注意 (2026-08-15)
 > 2026-08-15 02:31 (sources-sync 2507925) 抓取失败 / 数据被清空:本页 `上次同步` 字段从 `2026-08-12T18:30:03Z · 6614` 变为 `2026-08-14T18:30:42Z · 0`,13 个表记录数全部被清空。`2507925` commit 把空数据写入了 HEAD。`git show 1737454:sources/nocodb.md` 包含上一次成功抓取的 6614 记录数 — 该快照保留在这里以便后续修复。下次 sources-sync cron 跑时,如果 2507925 bug 不复现,本表会再次填满。**当前 HEAD 上的数据是损坏的快照,不是真实 NocoDB 数据**;真实 NocoDB 数据按上次成功抓取记录是 6614。
@@ -0,0 +1,18 @@
 ---
 type: Reference
 title: OpenWiki Upgrade Drift (auto-generated)
 last_checked: 2026-08-15T20:00:03Z
 ---
 # OpenWiki Upgrade Drift
 - Local installed: `v0.3.1`
 - npm latest: `v0.3.3`
 - Last checked: 2026-08-15T20:00:03Z
 ## Action (manual, no auto-upgrade)
 ```bash
 npm install -g openwiki@latest
 ```
 > **WARNING**: v0.3.1 → v0.4+ 可能有 breaking change. Read release notes first.
@@ -1,15 +1,9 @@
 ---
 type: "Reference"
 title: "RAGFlow 全文检索索引 (Robin KB system)"
 openwiki_generated: true
 ---
 # RAGFlow 全文检索索引 (Robin KB system)
 > 数据源: RAGFlow (http://10.10.10.254:9980/) 14 个 KB 全文检索结果
 > 用途: MiniMax code / Hermes 跨 agent 问 "Robin 的 RAGFlow 里有什么"
 > 更新: 自动同步可用性 + 手动维护 KB 列表
-> 上次同步: **2026-08-12T18:30:03Z** · landing 200 · /api/v1/datasets 401
+> 上次同步: **2026-08-21T18:30:02Z** · landing 200 · /api/v1/datasets 401
 ## RAGFlow 服务可用性
@@ -21,9 +15,5 @@ openwiki_generated: true
 > 注意: 2026-07-17 起 Robin 桌面 embedding / bge-reranker 服务宕机,导致 NAS 上 RAGFlow KB retrieval (向量检索) 不可用,但元数据 + 文档下载仍 OK,KB 内容同步 (chunks 拉 + 本地 keyword grep) 走降级路径。
 ## 操作注意 (2026-08-15)
 > 2026-08-15 02:31 (sources-sync 2507925) 抓取失败 / 数据被清空:本页 `上次同步` 字段从 `2026-08-12T18:30:03Z · landing 200 · /api/v1/datasets 401` 变为 `2026-08-14T18:31:10Z · landing 000 · /api/v1/datasets 000`,可用性表三个 endpoint 都从 200/404/401 变为 000/000/000。`2507925` commit 把空数据写入了 HEAD。**当前 HEAD 上的 RAGFlow 可用性是损坏的快照,不是真实数据**;真实 RAGFlow 状态按上次成功抓取记录是 landing 200 + /api/v1/datasets 401 (即控制台可达、API KB 列表 endpoint 返回 401)。
 ## 14 个 KB 状态 (验证于 2026-07-16)
 ...
@@ -1,15 +1,9 @@
 ---
 type: "Reference"
 title: "SeaFile 大文件存储索引"
 openwiki_generated: true
 ---
 # SeaFile 大文件存储索引
 > 数据源: SeaFile (http://10.10.10.254:9898/) 共 N 个资料库
 > 用途: MiniMax code / Hermes 跨 agent 上传 / 分享 / 删除文件
 > 更新: 自动（每天 02:30 同步,sources/seafile.md 刷新）
-> 上次同步: **2026-08-12T18:30:03Z** · 
+> 上次同步: **2026-08-21T18:30:02Z** · 
 ## 配置 (v1.2 skill, 2026-07-16)
@@ -37,7 +31,3 @@ openwiki_generated: true
 - 自动触发: `~/.local/bin/openwiki-update-sources.sh` (每天 02:30)
 - 手动触发: `bash ~/.local/bin/openwiki-update-sources.sh`
 - 数据格式: 跟 `seafile-util` skill 共用 (Token / 9898 port / 401 fallback)
 ## 操作注意 (2026-08-15)
 > 2026-08-15 02:31 (sources-sync 2507925) 抓取失败 / 数据被清空:本页 `上次同步` 字段从 `2026-08-12T18:30:03Z` 变为 `2026-08-14T18:30:45Z`。注:SeaFile 资料库表 (4-6 个) 在 2026-08-12 已为空 (172ea96 等历史 commit 也是空表头 + 空内容),所以 2026-08-15 的清空对 SeaFile 来说是无操作 (没有从非空到空的状态变化);真正受 2026-08-15 bug 影响的是 NocoDB / Wiki.js / RAGFlow (从 6614/83/200 变为 0/0/000)。SeaFile 资料库表为空本身是更早的、尚未被修复的 cron issue — `git show 1737454:sources/seafile.md` 与 `git show 2507925:sources/seafile.md` 表内容一致(都是空)。
@@ -2,12 +2,53 @@
 type: "Reference"
 title: "Web Search Evidence"
 description: "Compact, source-backed evidence and ingestion coverage for the web-search-1 Tavily lane tracking CelVivo, 3Brain, Cellink, and related organoid news."
-tags: [source, web-search, tavily, celvivo, 3brain, cellink, organoids, 2026-08-12, 2026-08-15]
+tags: [source, web-search, tavily, celvivo, 3brain, cellink, organoids, 2026-08-12, 2026-08-15, 2026-08-16, 2026-08-17, 2026-08-18, 2026-08-19, 2026-08-20, 2026-08-21]
 timestamp: 2026-08-21T18:35:00Z
 ---
 # Web Search Evidence
-> Connector: `web-search-1` (Tavily). This page records compact, relevant evidence from Tavily pulls; search results are discovery leads, not vendor-confirmed announcements. Latest successful pull: 2026-08-03 18:08 UTC. The 2026-08-08, 2026-08-10, 2026-08-12, and 2026-08-15 update attempts were skipped because the connector is disabled and `TAVILY_API_KEY` is not present; no new 24-hour evidence was available on any of these four runs.
+> Connector: `web-search-1` (Tavily). This page records compact, relevant evidence from Tavily pulls; search results are discovery leads, not vendor-confirmed announcements. Latest successful pull: 2026-08-03 18:08 UTC. The 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, 2026-08-17, 2026-08-18, 2026-08-19, 2026-08-20, and 2026-08-21 update attempts were skipped because the connector is disabled and `TAVILY_API_KEY` is not present; no new 24-hour evidence was available on any of these nine runs.
 ## 2026-08-21 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. The nightly searxng-fallback slot (`~/.openwiki/connectors/web-search/raw/2026-08-20T18-35-03-searxng-fallback/`) is also empty (confirmed empty on disk) — no web-search evidence of any kind landed in the 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, 2026-08-17, 2026-08-18, 2026-08-19, and 2026-08-20 runs hit the same blocker; this is the **ninth consecutive skip on the same code path**. To resolve: set `TAVILY_API_KEY` in the OpenWiki runtime environment and ensure the runtime registry refreshes the connector's enabled state.
 ## 2026-08-20 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. The nightly searxng-fallback slot (`~/.openwiki/connectors/web-search/raw/2026-08-19T18-35-03-searxng-fallback/`) is also empty — no web-search evidence of any kind landed in the 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, 2026-08-17, 2026-08-18, and 2026-08-19 runs hit the same blocker; the 2026-08-21 run hit the same blocker too. This was the **eighth consecutive skip on the same code path at the time of the 2026-08-20 attempt** (and the ninth skip including the 2026-08-21 follow-up). To resolve: set `TAVILY_API_KEY` in the OpenWiki runtime environment and ensure the runtime registry refreshes the connector's enabled state.
 ## 2026-08-19 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. The nightly searxng-fallback slot (`~/.openwiki/connectors/web-search/raw/2026-08-18T18-35-03-searxng-fallback/`) is also empty — no web-search evidence of any kind landed in the 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, 2026-08-17, and 2026-08-18 runs hit the same blocker; the 2026-08-20 and 2026-08-21 runs hit the same blocker too. This was the **seventh consecutive skip on the same code path at the time of the 2026-08-19 attempt** (and the ninth skip including the 2026-08-20 and 2026-08-21 follow-ups). To resolve: set `TAVILY_API_KEY` in the OpenWiki runtime environment and ensure the runtime registry refreshes the connector's enabled state.
 ## 2026-08-18 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. The nightly searxng-fallback slot (`~/.openwiki/connectors/web-search/raw/2026-08-17T18-35-03-searxng-fallback/`) is also empty — no web-search evidence of any kind landed in the 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, 2026-08-12, 2026-08-15, and 2026-08-17 runs hit the same blocker; the 2026-08-19, 2026-08-20, and 2026-08-21 runs hit the same blocker too. This was the **sixth consecutive skip on the same code path at the time of the 2026-08-18 attempt** (and the ninth skip including the 2026-08-19, 2026-08-20, and 2026-08-21 follow-ups).
 ## 2026-08-17 attempted update — skipped
 - **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. The nightly searxng-fallback slot (`~/.openwiki/connectors/web-search/raw/2026-08-16T18-35-03-searxng-fallback/`) is also empty — no web-search evidence of any kind landed in the 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
 - **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, 2026-08-12, and 2026-08-15 runs hit the same blocker; the 2026-08-18, 2026-08-19, 2026-08-20, and 2026-08-21 runs hit the same blocker too. This was the **fifth consecutive skip on the same code path at the time of the 2026-08-17 attempt** (and the ninth skip including the 2026-08-18, 2026-08-19, 2026-08-20, and 2026-08-21 follow-ups).
 ## 2026-08-15 attempted update — skipped
@@ -15,7 +56,7 @@ tags: [source, web-search, tavily, celvivo, 3brain, cellink, organoids, 2026-08-
 - **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
 - **Coverage:** no raw data files were written for this attempted 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
 - **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
- **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, and 2026-08-12 runs hit the same blocker; this is the fourth consecutive skip on the same code path.
+- **Operational note (cross-check):** the on-disk `~/.openwiki/connectors/web-search/config.json` does show `enabled: true` plus 6 Chinese-language queries (`CelVivo ClinoStar ClinoReactor 类器官培养新进展`, `3Brain HD-MEA 高密度微电极阵列 电生理`, `Cellink BIO X 3D生物打印 类器官`, `Femtobiomed CellShot 流式电转 精准医疗`, `类器官 vendor 2026年新发布`, `MiniMax M3 智能体 Hermes`). The agent runtime still reports the connector as disabled, so there is a discrepancy between disk config and runtime registry. This is an operational concern (connector enable / auth / re-registration), not a wiki-synthesis concern, and is recorded here for traceability rather than triggering wiki edits. The 2026-08-08, 2026-08-10, and 2026-08-12 runs hit the same blocker; the 2026-08-17, 2026-08-18, 2026-08-19, 2026-08-20, and 2026-08-21 runs hit the same blocker too. This was the fourth consecutive skip on the same code path at the time of the 2026-08-15 attempt (and the ninth skip including the 2026-08-17, 2026-08-18, 2026-08-19, 2026-08-20, and 2026-08-21 follow-ups).
 ## 2026-08-12 attempted update — skipped
@@ -494,6 +535,7 @@ Every query in the 10-query lane returned the same structured error (no answer t
 - Pull 10: fetched 2026-08-02T18:07:53Z — raw `~/.openwiki/connectors/web-search/raw/2026-08-02T18-06-12-521Z/web-search-results.json` — **all 10 queries returned `"error": "fetch failed"`; no usable evidence**
 - Pull 11: fetched 2026-08-03T18:08:50Z — raw `~/.openwiki/connectors/web-search/raw/2026-08-03T18-07-31-803Z/web-search-results.json` — **first successful pull after the 3-day outage streak; Tavily back online; see section below**
 - Pull 12: attempted 2026-08-10T18:35Z — **skipped** (connector reported disabled; `TAVILY_API_KEY` not present; no raw files written; no synthesis update)
 - 2026-08-12 / 2026-08-15 / 2026-08-17 / 2026-08-18 / 2026-08-19 / 2026-08-20 / 2026-08-21 update attempts: all **skipped** on the same code path (connector reported disabled; `TAVILY_API_KEY` not present; no raw files written; no synthesis update; ninth consecutive skip including 2026-08-21); see individual sections above for per-day operational notes
 - Queries: pulls 1, 2, 4, 5, 6, 7, 8, 9, 10, 11 = 10 queries each; pull 3 = 6 queries (vendor-anchored only)
 - Instance: `web-search-1`
@@ -566,3 +608,25 @@ Eleventh Tavily pull, run as a stand-alone `openwiki personal --update` source i
 - **Tavily answer-text quality:** the 3Brain answer is now correct (first time in 11 pulls); the Cellink Lumen X answer is substantive; the Hermes/M3 answer is partially fabricated ("release date of June 1, 2026") — treat as untrusted. Connector-side quality flag for future pulls: continue to treat Tavily answer text as untrusted; trust the underlying URL + score + published_date.
 - **Operational note for the connector:** Tavily is back online after a 3-day outage streak. The pull 8 / pull 9 / pull 10 advice to check `TAVILY_API_KEY`, Tavily status, and rate-limit posture no longer applies — the lane is functional again. No connector-side configuration change is required.
 - **Coverage:** fetched `2026-08-03T18:08:50.866Z`; 10 queries; raw `~/.openwiki/connectors/web-search/raw/2026-08-03T18-07-31-803Z/web-search-results.json`; instance `web-search-1`.
 on the existing `3brain-coreplate-2026-conference-positioning` verification commitment. No new commitment; existing commitment Notes are extended.
  3. **CelVivo ClinoStar 2 / Thailand Lab 2026** — independent confirmation from an Indian distributor event page on the existing `celvivo-clinostar-2-nams-demo-2026` verification commitment. No new commitment; existing commitment Notes are extended.
 - **Workflow tooling refreshes:** `agent-memory-architecture` Last seen → 2026-08-03 (akitaonrails/ai-memory research doc added). `hermes-agent-v0-19-quicksilver` and `MiniMax-m3` evidence columns refreshed with same-week artifacts (Last seen unchanged at 2026-08-03 from the HN pull).
 - **Tavily answer-text quality:** the 3Brain answer is now correct (first time in 11 pulls); the Cellink Lumen X answer is substantive; the Hermes/M3 answer is partially fabricated ("release date of June 1, 2026") — treat as untrusted. Connector-side quality flag for future pulls: continue to treat Tavily answer text as untrusted; trust the underlying URL + score + published_date.
 - **Operational note for the connector:** Tavily is back online after a 3-day outage streak. The pull 8 / pull 9 / pull 10 advice to check `TAVILY_API_KEY`, Tavily status, and rate-limit posture no longer applies — the lane is functional again. No connector-side configuration change is required.
 - **Coverage:** fetched `2026-08-03T18:08:50.866Z`; 10 queries; raw `~/.openwiki/connectors/web-search/raw/2026-08-03T18-07-31-803Z/web-search-results.json`; instance `web-search-1`.
 queries; raw `~/.openwiki/connectors/web-search/raw/2026-08-03T18-07-31-803Z/web-search-results.json`; instance `web-search-1`.
 ion commitment. No new commitment; existing commitment Notes are extended.
  3. **CelVivo ClinoStar 2 / Thailand Lab 2026** — independent confirmation from an Indian distributor event page on the existing `celvivo-clinostar-2-nams-demo-2026` verification commitment. No new commitment; existing commitment Notes are extended.
 - **Workflow tooling refreshes:** `agent-memory-architecture` Last seen → 2026-08-03 (akitaonrails/ai-memory research doc added). `hermes-agent-v0-19-quicksilver` and `MiniMax-m3` evidence columns refreshed with same-week artifacts (Last seen unchanged at 2026-08-03 from the HN pull).
 - **Tavily answer-text quality:** the 3Brain answer is now correct (first time in 11 pulls); the Cellink Lumen X answer is substantive; the Hermes/M3 answer is partially fabricated ("release date of June 1, 2026") — treat as untrusted. Connector-side quality flag for future pulls: continue to treat Tavily answer text as untrusted; trust the underlying URL + score + published_date.
 - **Operational note for the connector:** Tavily is back online after a 3-day outage streak. The pull 8 / pull 9 / pull 10 advice to check `TAVILY_API_KEY`, Tavily status, and rate-limit posture no longer applies — the lane is functional again. No connector-side configuration change is required.
 - **Coverage:** fetched `2026-08-03T18:08:50.866Z`; 10 queries; raw `~/.openwiki/connectors/web-search/raw/2026-08-03T18-07-31-803Z/web-search-results.json`; instance `web-search-1`.
 queries; raw `~/.openwiki/connectors/web-search/raw/2026-08-03T18-07-31-803Z/web-search-results.json`; instance `web-search-1`.
 .
 h-1`.
 penwiki/connectors/web-search/raw/2026-08-03T18-07-31-803Z/web-search-results.json`; instance `web-search-1`.
 h-1`.
 nwiki/connectors/web-search/raw/2026-08-03T18-07-31-803Z/web-search-results.json`; instance `web-search-1`.
 h-1`.
@@ -1,15 +1,9 @@
 ---
 type: "Reference"
 title: "Wiki.js 索引 — 跨 agent 文档发布层"
 openwiki_generated: true
 ---
 # Wiki.js 索引 — 跨 agent 文档发布层
 > 数据源: Wiki.js (http://10.10.10.254:3000/graphql) Biokingdom 实例
 > 用途: MiniMax code / Hermes 跨 agent 检索 "Robin 在 Wiki.js 发布了什么"
 > 更新: 自动同步计数 + 手动维护目录
-> 上次同步: **2026-08-12T18:30:03Z** · GraphQL sample (5 orderBy union): **83 unique pages** · ID range 22..1704 · 分布 en=5, zh=78
+> 上次同步: **2026-08-21T18:30:02Z** · GraphQL sample (5 orderBy union): **83 unique pages** · ID range 22..1704 · 分布 en=5, zh=78
 ## Wiki.js 概况
@@ -28,10 +22,6 @@ openwiki_generated: true
 > ⚠️ **GraphQL `pages.list(limit:N)` 实际 server-side cap 到 ~50**,无论 N 多大。**Robin 的真实 Wiki.js 库 ≥ 1000+ 页** (按 max page id 推断),我 7/27 早的 "47" sample 是 server-side cap 的产物,**不是真实数**。多种 orderBy (TITLE / UPDATED / CREATED / ID / PATH) 5 个排序 union 才能看到 max_id,但仍未遍历完 1500+ 全部 page。完整全量只能通过爬 frontend / 直查 DB / 翻 Wiki.js 内部 API — 本 cron 不做。
 ## 操作注意 (2026-08-15)
 > 2026-08-15 02:31 (sources-sync 2507925) 抓取失败 / 数据被清空:本页 `上次同步` 字段从 `2026-08-12T18:30:03Z · 83 unique pages · ID range 22..1704` 变为 `2026-08-14T18:31:00Z · 0 unique pages · ID range 0..0`,概况表所有计数被清空 (estimated count → ≥0 / sample union → 0 / min/max ID → 0/0 / Locale 分布 → empty / 路径分布 → empty)。`2507925` commit 把空数据写入了 HEAD。`git show 1737454:sources/wikijs.md` 包含上一次成功抓取的 83 unique pages + ID range 22..1704 — 该快照保留在这里以便后续修复。**当前 HEAD 上的 Wiki.js 计数是损坏的快照,不是真实数据**;真实 Wiki.js 数据按上次成功抓取记录是 ≥1704 全页 / sample union 83 / ID range 22..1704。
 ## 主要页面分类 (按 URL path)
 ### 类器官 (organoid/list/*)
@@ -61,6 +61,7 @@ The state diagram shows the canonical CelVivo → 3Brain workflow: 3D suspension
 - **Bosnjakovic 2025 bioRxiv (PAH HepG2 3D spheroid, ClinoStar dynamic culture)** — 21-day maturation + 24h/96h BaP/BBF exposure; **4 metabolic markers (phenylalanine, TCA intermediates, GSH depletion, sphingolipid dysregulation) only appear in 3D, completely invisible in 2D**. Sales ammunition: "your 2D model is missing 100% of environmental toxicology early signals". Synthesis at [`/sources/literature-cel-bosnjakovic-2025-pah-deepread.md`](/sources/literature-cel-bosnjakovic-2025-pah-deepread.md).
 - **Miao 2025 Cell v2 (co-differentiation mesoderm + endoderm, vascularized lung/gut organoids, ClinoStar rotating culture)** — single 3D EB co-induction strategy yields **vHLPO with 7% ECs vs traditional HLPO 0%**, organ-specific endothelium + mesenchyme scRNA-seq validation, in-vivo functional integration with host circulation, FOXF1 mutation ACDMPV dual-pathology disease modeling. Product relevance: CelVivo ClinoStar rating 5 (co-differentiation depends on 3D EB self-organization in low-shear rotating culture — ClinoStar is the canonical hardware), HD-MEA rating 4, 3D bioprinting rating 3, patient-derived organoid drug screening rating 5. Synthesis at [`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`](/sources/literature-miao-2025-cell-vascularization-v2-deepread.md).
 - **Liu 2026 Nat Biomed Eng (shape-conformal porous framework for neural organoid e-phys, Rogers Lab)** — CelVivo ClinoStar rating 4 (organoid culture downstream of the shape-conformal framework; long-term maturation + functional readout is the canonical ClinoStar → HD-MEA workflow). Synthesis at [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md). See 3Brain evidence for the HD-MEA read side.
 - **Quintard 2024 Nat Commun (microfluidic platform integrating functional vascularized organoids-on-chip, 2026-08-16)** — CelVivo ClinoStar rating 3 (upstream workflow: BVO differentiation day 0-15 needs rotating-wall suspension culture; ClinoStar is the canonical hardware for this stage; the paper's day 15 → chip-on-board handoff is the canonical CelVivo → organ-on-chip workflow). Mimetas OrganoPlate rating 4 (direct Phaseguide-based vascularized / kidney / intestine organ-on-chip competitor — Robin's portfolio does not currently cover Mimetas but the platform represents a candidate cross-sell if Robin's customers ask "where do I run my CelVivo-matured organoids in a vascularized microenvironment?"). Emulate Organ-Chip rating 3 (Colon-Intestine-Liver platform companion). 10 通道并行微流控芯片 + hiPSC-BVO + 间充质球体 + 胰岛球体 + 肺类器官 跨类器官验证; 血管层级化 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管; 壁剪切 27-2000 s⁻¹ 完美匹配人体毛细血管生理范围 50-1900 s⁻¹. 4-commit LDR cycle 2026-08-16 (commits `0fc8db24` → `290e9635` → `24c713de` → `4073abf4` — last commit deleted the 3Brain reference per the SOP "硬门槛合规修正" cleanup rule because Quintard is organ-on-chip territory rather than 3Brain territory). Wiki IDs 1719/1720/1722, NocoDB Id 3297, DOI 10.1038/s41467-024-45710-4. Sales ammunition: "你的类器官前段培养到 day 15, 后段血管化怎么接? 我们的 CelVivo ClinoStar 提供 day 0-15 金标准旋转培养, 后接 Quintard 2024 微流控芯片做 30 天功能性血管化灌注". Customer entry: 药企临床前 (vascularized drug screening) + 微流控 organ-on-chip 平台集成商 (Mimetas / Emulate channel partners) + academic PI (vascular development / diabetes). Vault path: `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` (189 lines + 6 真图).
 - **Liang 2026 Sci Rep (mouse liver organoid 3-轨道 + fibrosis modeling, 2026-08-12)** — CelVivo ClinoStar rating 4 (P1-P10 长程扩增对应旋转培养 30+ 天无剪切; single DAPT only sustains P5, DAPT+Dex 协同才实现 P10 稳定成熟), CelVivo ClinoReactor rating 4 (单组织 3 轨道 [Hep/Cho/HSC] 分通道灌流; TGFβ 时间程序精确切换实现纤维化激活模型), CelVivo PhaseHolographic 成像 rating 3 (3D 球体直径/CV 实时 QC), 3Brain HD-MEA rating 3 (肝-神经互作延伸场景). 3 轨道 from 单份小鼠肝组织 (密度梯度离心 + 差速贴壁) → DAPT+Dex P1-P10 长程稳定成熟 (ALB / PAS / LDL / CYP 跨代保持) → TGFβ 5-7 天激活 qHSC → aHSC (Acta2/Col1a1 上调) → aHSC 共培养诱导 Hep-Orgs EMT (Snail/Twist/Vimentin ↑; ALB/CK8 ↓; Lgr5/EpCAM ↓; Ki67 ↓) = 体外肝纤维化模型. Wiki.js Id=1716, NocoDB Id=770, PMID 41857098. Page 946 9 项 SOP 重写版 + page 934 修齐 标杆 (4-commit LDR cycle 2026-08-12). **First deep-read whose `related:` field already names `[[MOC-类器官与3D培养]]`** on the day of publication — confirms MOC pattern in active use on real deep-reads. Vault path: `04-Literature/Deep-Reads/Liver/2026-08-12_Liang_2026_SciRep_liver_organoid_fibrosis_platform.md` (170 lines). Sales ammunition: "你的肝类器官只能短期培养? DAPT+Dex P1-P10 稳定成熟 + 单组织 3 轨道 + 14 天纤维化模型 — ClinoStar + ClinoReactor 一站搞定". Customer entry: 药企临床前 (抗纤维化药筛 14+ 天 3D 多细胞模型) + 临床肝活检中心 (1-2 mg 组织 → 3 周药敏 → ClinoReactor 6 通道一次测 6 药). Tracks in `/commitments.md` as `liang-2026-celvivo-clinostar-positioning`.
 - **Sales ammunition kit (CelVivo pricing + 8 Protocols + 5 app notes + 5 brand/whitepapers)** — Demo kit `10005-6` lists at €300 (Global Distributor Price, with special discount). 8 ClinoReactor Protocols cover prepare / media change / gardening / plate config / rotation-speed / alginate embed / VitroGel embed. 5 application notes cover HepG2/C3A liver, FTC-133 thyroid, NCI-H69V SCLC, TNBC, ClinoStar vs Orbital Shaker. Synthesis at [`/sources/sales-ammunition.md`](/sources/sales-ammunition.md).
 - **260528_CS vs OS app note (2026-07-17 deep read)** — ClinoStar vs Orbital Shaker shear-stress comparison for long-term 3D construct performance; ClinoStar has lower shear + long-term growth + better consistency. This is the **vs-competitor killer document** for "why not use an orbital shaker" customer questions.
@@ -93,6 +94,7 @@ The state diagram shows the canonical CelVivo → 3Brain workflow: 3D suspension
 - **China CDE cell & gene therapy classification rules (2026-07-24)** — affects CelVivo-class deals in the Chinese pharma R&D / CDMO customer base. Tracks in [`/commitments.md`](/commitments.md) `china-cde-cell-gene-therapy-rules-2026`.
 - **China Order No. 818 (effective 2026-05-01)** — accelerated clinical-translation pathway for cell therapy and 3D bioprinting at qualified hospitals. Tracks as `china-order-no-818-clinical-translation`.
 - **Guo 2026 Front Cell Dev Biol organoid IRB / ethics systematic review (2026-08-16)** — CelVivo ClinoStar ⭐⭐⭐⭐ clinical-translation IRB compliance; **Robin 推广 ClinoStar 给三甲医院时, 可附带 Guo 2026 框架作为增值**. The paper structures the IRB review framework as 7 mandatory points (sample provenance + donor informed consent + data privacy & de-identification + co-culture agency + animal welfare 3R + cross-border regulation + long-term storage & termination) + a 5-jurisdiction cross-border table (China《人类遗传资源管理条例》+《涉及人的生命科学和医学研究伦理审查办法》2023 vs US HIPAA + Common Rule + NIH GDS vs EU GDPR + Clinical Trials Regulation 536/2014 vs Japan / Korea). 3-commit LDR cycle 2026-08-16 (`2e6f5989` → `00f824f2` → `a4fa5a32`). Wiki.js ID 1724, NocoDB Id 3298, DOI 10.3389/fcell.2026.1721946. **Robin translated the paper into a customer-facing IRB application checklist template** at `templates/类器官IRB申请清单.md` v1.0 (180 lines; 7 mandatory points checklist + 5 customer Q&A + China vs International flow table + 10 attachments + 7 citations). Tracks in `/commitments.md` as `guo-2026-organoid-irb-checklist-rollout` (Owner: me; fold IRB application checklist into CelVivo industrial-customers program + Robin customer-training core material; commit the template and add a synthesis page at `/sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md`). Vault path: `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` (170 lines + 3 真图).
 - **China CGT 2026-07 developments** — Merck–Bio-Techne $11.3B acquisition, CARsgen satri-cel solid-tumor CAR-T approval (positive); gene-editing trial death + regulatory backlash (negative). Tracks as `china-cgt-2026-july-developments`.
 ## Cross-cutting relationship
@@ -112,8 +114,11 @@ The state diagram shows the canonical CelVivo → 3Brain workflow: 3D suspension
 | What is Liu 2026's shape-conformal neural organoid e-phys story? | [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md) |
 | What is Sharma 2026's vascularized retinal organoid RGC story? | [`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`](/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md) |
 | What is Liang 2026's liver organoid fibrosis platform story? | `04-Literature/Deep-Reads/Liver/2026-08-12_Liang_2026_SciRep_liver_organoid_fibrosis_platform.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
 | What is Quintard 2024's vascularized organoid chip story? | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
 | What is Guo 2026's organoid IRB / ethics story? | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
 | What is the IRB application checklist for organoid research? | `templates/类器官IRB申请清单.md` v1.0 (vault path; untracked) |
 | What distributors am I actually working with? | [`/sources/agents.md`](/sources/agents.md) |
 | Which Chinese dealers carry our brand? | [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) |
-| What regulatory shifts affect our Chinese pharma deals? | [`/commitments.md`](/commitments.md) China CDE / Order No. 818 / China CGT items |
+| What regulatory shifts affect our Chinese pharma deals? | [`/commitments.md`](/commitments.md) China CDE / Order No. 818 / Guo 2026 IRB / China CGT items |
 | What conferences is 3Brain at this season? | [`/commitments.md`](/commitments.md) `3brain-coreplate-2026-conference-positioning` |
 | What's the CelVivo → 3Brain joint workflow? | [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) (this page) Workflow chain section |
@@ -2,8 +2,8 @@
 type: "Reference"
 title: "Theme 5 · Robin's personal research (vendor deep reads + sales ammunition + CRM)"
 description: "Synthesis page for Robin's personal research portfolio — Obsidian vault + literature deep-read pipeline + sales ammunition + China distributor map + active CRM profiles + work-rhythm snapshots. Output routes into vendor themes 01 (organoid-equipment) and 02 (bioprinting)."
-tags: [theme, research, vault, deep-read, sales, crm, life-sciences, 2026-08-15, 2026-08-13]
+tags: [theme, research, vault, deep-read, sales, crm, life-sciences, 2026-08-21, 2026-08-20, 2026-08-19, 2026-08-18, 2026-08-17, 2026-08-15, 2026-08-13]
-timestamp: 2026-08-15T18:07:49Z
+timestamp: 2026-08-21T18:09:00Z
 ---
 # Theme 5 · Robin's personal research (vendor deep reads + sales ammunition + CRM)
@@ -23,7 +23,7 @@ This is the synthesis page for **Robin 个人研究项目** — the durable body
 ```mermaid
 erDiagram
-    VAULT["Obsidian vault (297f106d)"] ||--o{ DEEPREADS["Deep-read notes ~1,205"]
+    VAULT["Obsidian vault (a4fa5a32)"] ||--o{ DEEPREADS["Deep-read notes ~1,207"]
    VAULT ||--o{ TRAIN["Sales training (CelVivo赋能培训 v1-v9)"]
    VAULT ||--o{ SALES["Active sales pipeline (惠百生物 PO + 中间商)"]
    VAULT ||--o{ CRM["Distributor profiles (董慧群 + 待补)"]
@@ -32,6 +32,7 @@ erDiagram
    VAULT ||--o{ MEMORY["Daily + weekly reports (memory/ 147 .md)"]
    VAULT ||--o{ ITX["ITX 24h host build (untracked)"]
    VAULT ||--o{ MOC["MOCs (类器官与3D培养 first, +planned)"]
    VAULT ||--o{ TEMPLATES["Templates (类器官IRB申请清单 v1.0, untracked)"]
    DEEPREADS }o--|| VENDOR["Vendor mapping"]
    VENDOR ||--|{ CelVivo["CelVivo (ClinoStar / ClinoReactor)"]
@@ -50,19 +51,19 @@ The diagram shows Robin's research substrate: a single Obsidian vault with 8 buc
 ## Knowledge substrate: Obsidian vault
-Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08-15T18:07:49Z):
+Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08-21T18:09:00Z):
 | Field | Value |
 | --- | --- |
 | Repo path | `/home/ldw/workspace` |
 | Branch | `main` |
-| HEAD | `297f106d2b137af3480261052ff080cbc48d5b48` (**unchanged** across both 2026-08-13 and 2026-08-15 fetches — 0 new vault commits in the 2026-08-13T18:08Z → 2026-08-15T18:07Z 48-hour window; the 2026-08-12 Liang 2026 4-commit LDR cycle remains the most recent vault activity) |
+| HEAD | `a4fa5a323d6dcabeb9eccad49e636ee6ba5f87a6` (**unchanged** at the 2026-08-21T18:09Z fetch — **0 new vault commits** in the 2026-08-20T18:09Z → 2026-08-21T18:09Z 24-hour window; vault is silent for the **5th consecutive fetch** after the 2026-08-17T18:09Z + 2026-08-18T18:10Z + 2026-08-19T18:08Z + 2026-08-20T18:09Z silent windows; **5 calendar days stale** since the last vault HEAD bump on 2026-08-16; the 2026-08-16 Quintard 2024 Nat Commun 4-commit LDR cycle + Guo 2026 Front Cell Dev Biol 3-commit LDR cycle remain the most recent vault activity) |
-| Ahead of origin/main | 13 commits new since 2026-08-03 fetch (Fernandez Vallone 2026 + Microbioreactor 2026 + Liu 2026 v2-v11 + 4 经销商 hook 升级 + Wang 2024 Theranostics + **Phase A metadata batch + 2 sample runs** + **Liang 2026 liver organoid fibrosis platform 4-commit LDR cycle**); plus **23 untracked files** in working tree (unchanged from the 2026-08-13 fetch — 0 new untracked files appeared in the 2026-08-13T18:08Z → 2026-08-15T18:07Z 24-hour window) |
+| Ahead of origin/main | 20 commits new since 2026-08-03 fetch (unchanged from the 2026-08-17 + 2026-08-18 + 2026-08-19 + 2026-08-20 + 2026-08-21 fetches) |
 | Auth | local path only — no remote, no credentials |
-| Working-tree state | dirty (1 nested-submodule + 1 untracked dir + 23 untracked files including 8 new `02-Clients/Agents/区域-2026-0807.md` + the still-untracked `Review/zhou2023_computer_vision_microfluidics.md` first-entry-in-Review/-subfolder file) |
+| Working-tree state | dirty (23 untracked files + 2 new untracked directories — `celvivo_commercial/1331651_20260630_131201.pdf` + `templates/类器官IRB申请清单.md` — both untracked; the `Review/zhou2023_computer_vision_microfluidics.md` first-entry-in-Review/-subfolder is still-uncommitted, carrying forward from the 2026-08-13 fetch, **10-day carry-forward** at the 2026-08-21T18:09Z fetch — **8 fetches silent** on the file) |
-| Raw manifest | `~/.openwiki/connectors/git-repo/raw/2026-08-15T18-07-49-711Z/manifest.json` |
+| Raw manifest | `~/.openwiki/connectors/git-repo/raw/2026-08-21T18-08-59-795Z/manifest.json` |
-| **Latest cluster (2026-08-12, unchanged across both 2026-08-13 + 2026-08-15 fetches)** | **Liang 2026 Sci Rep liver organoid fibrosis platform 4-commit LDR cycle** (`e542c977` adds file 186 lines → `8699a154` page 946 9 项 SOP 重写版 105+/122- → `aacba7aa` frontmatter title 改中文 1 line → `297f106d` page 934 修齐 5+/4-) — **net-new external evidence** (DOI 10.1038/s41598-026-42990-2, PMID 41857098, mouse liver 3-轨道 Hep-Orgs + Cho-Orgs + HSC + DAPT+Dex P1-P10 长程成熟 + TGFβ 激活体外纤维化模型) |
+| **Latest cluster (2026-08-16, replacing the 2026-08-12 Liang 2026 cluster)** | **Quintard 2024 Nat Commun + Guo 2026 Front Cell Dev Biol 7-commit LDR cluster** (`0fc8db24` Quintard adds file 189 lines → `290e9635` -v2 → `24c713de` -v3 → `4073abf4` -v4 → `2e6f5989` Guo adds file 170 lines → `00f824f2` -v2 → `a4fa5a32` -v3) — **net-new external evidence** (DOI 10.1038/s41598-026-42990-2, PMID 41857098, mouse liver 3-轨道 Hep-Orgs + Cho-Orgs + HSC + DAPT+Dex P1-P10 长程成熟 + TGFβ 激活体外纤维化模型) |
-| **Latest uncommitted file (2026-08-13, still-uncommitted at 2026-08-15)** | `04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md` — **first entry in the new `Review/` subfolder**; review-type papers stream separately from original-research stream; carry-forward status unchanged across the 2026-08-13 + 2026-08-15 fetches |
+| **Latest uncommitted artifact (2026-08-13 → 2026-08-21, multi-file, unchanged at the 2026-08-21T18:09Z fetch)** | `04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md` (carry-forward untracked from 2026-08-13, now at **10-day carry-forward** at the 2026-08-21 fetch — file mtime `2026-08-11 16:31:54 +0800` so mtime-based carry-forward is 10 days; first-observation-date-based carry-forward is 8 days; **structural signal continuing to weaken** per `/sources/git-repo.md` Notable-entity entry — 8 consecutive fetches silent on the file; subfolder is more likely a one-off than a recurring pattern) + **2 new untracked directories added at the 2026-08-17 fetch**, still-uncommitted at the 2026-08-21 fetch (**5-day carry-forward** each — was 4-day at the 2026-08-20 fetch): `celvivo_commercial/1331651_20260630_131201.pdf` (6-30 quote PDF migrated into new folder) + `templates/类器官IRB申请清单.md` (180-line IRB application checklist derived from Guo 2026; Robin's first customer-facing template produced from a single deep-read — see the new Templates subtree below) |
 ### Vault navigation index (top-level folders)
@@ -91,7 +92,7 @@ Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08
 | Subfolder | .md count | Vendor / scope |
 | --- | ---: | --- |
-| `Organoid/` | 659 | broad organoid literature |
+| `Organoid/` | 661 (+2 from 2026-08-16 — Quintard 2024 Nat Commun microfluidic vascularized organoid chip + Guo 2026 Front Cell Dev Biol organoid ethics systematic review) | broad organoid literature |
 | `Celvivo/` | 142 | CelVivo vendor + CelVivo-adjacent papers |
 | `3Brain/` | 136 | 3Brain vendor + 3Brain-adjacent papers |
 | `Cellink/` | 129 | Cellink vendor + Cellink-adjacent papers |
@@ -109,9 +110,11 @@ Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08
 | `Retinal/` | 1 | retinal organoid |
 | `Microbioreactor/` | 1 | Rosero 2026 Front Bioeng Biotechnol (added 2026-08-07) |
 | `Cells/` | 1 | Fernandez Vallone 2026 Cells THSDC (added 2026-08-08) |
-| `Review/` | 1 | Zhou 2023 computer vision + microfluidics (added 2026-08-13, **untracked**) |
+| `Review/` | 1 | Zhou 2023 computer vision + microfluidics (added 2026-08-13, **untracked**, **9-day carry-forward** at 2026-08-20 fetch (was 8-day at 2026-08-19) — **7 fetches silent** — structural signal continuing to weaken) |
 | `Templates/` | 1 | `类器官IRB申请清单.md` v1.0 (2026-08-16, derived from Guo 2026 ethics deep-read, **untracked**; first customer-facing template produced from a single deep-read; **4-day carry-forward** at 2026-08-20 fetch — was 3-day at 2026-08-19) |
 | `CelVivo-commercial/` | 1 | `1331651_20260630_131201.pdf` (2026-06-30 quote PDF migrated into new folder 2026-08-17, **untracked**; **4-day carry-forward** at 2026-08-20 fetch — was 3-day at 2026-08-19) |
-Total ≈ 1,204 deep-read notes on `main` + **1 untracked entry in the new `Review/` subfolder** (`zhou2023_computer_vision_microfluidics.md`, 2026-08-13 — first review-type subfolder; future-commit candidate). The 4 vendor subfolders (Celvivo / 3Brain / Cellink / Organoid) cover the canonical product KB per the wiki goal focus areas.
+Total ≈ 1,206 deep-read notes on `main` + **1 untracked entry in the new `Review/` subfolder** (`zhou2023_computer_vision_microfluidics.md`, 2026-08-13 — first review-type subfolder; future-commit candidate) + **2 new untracked directories** (`templates/类器官IRB申请清单.md` + `celvivo_commercial/1331651_20260630_131201.pdf`, 2026-08-17). The 4 vendor subfolders (Celvivo / 3Brain / Cellink / Organoid) cover the canonical product KB per the wiki goal focus areas. The new `templates/` folder signals Robin may be formalizing customer-facing deliverables (checklists / templates / sales scripts) as a separate vault subtree — the IRB application checklist is the first such artifact.
 ## Literature deep-read (LDR) pipeline
@@ -180,6 +183,8 @@ From [`/sources/ldr-report-template.md`](/sources/ldr-report-template.md) (Robin
 | Sharma 2026 Cell Stem Cell (2026-08-08 flywheel-sync) | 3Brain + CelVivo adjacent | `/home/ldw/workspace/retinal_organoid_deep_read_2026-08-07.md` | [`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`](/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md) |
 | Miao 2025 Cell v2 (2026-08-08 flywheel-sync) | CelVivo (ClinoStar rating 5) | `/home/ldw/workspace/Miao2025_Cell_v2.md` | [`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`](/sources/literature-miao-2025-cell-vascularization-v2-deepread.md) |
 | Liu 2026 Nat Biomed Eng (2026-08-08 flywheel-sync) | 3Brain (HD-MEA rating 5) + Cellink (microlattice rating 5) | `/home/ldw/workspace/Liu2026_NBME_shape_conformal_organoid.md` | [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md) |
 | Quintard 2024 Nat Commun (2026-08-16 vault LDR cluster) | CelVivo (ClinoStar rating 3 upstream) + Mimetas OrganoPlate (rating 4 direct) + Emulate Organ-Chip (rating 3) | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` | (not yet synthesized to `/sources/`) |
 | Guo 2026 Front Cell Dev Biol (2026-08-16 vault LDR cluster) | CelVivo (ClinoStar rating 4 clinical-translation IRB) + Mimetas OrganoPlate (rating 4 co-culture ethics) + Emulate Organ-Chip (rating 3) | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` | (not yet synthesized to `/sources/`; derived customer-facing template at `templates/类器官IRB申请清单.md` v1.0) |
 ## Recent 30-day research output (mtime 2026-06-16 → 2026-08-12)
@@ -187,6 +192,7 @@ From [`/sources/literature.md`](/sources/literature.md) last sync, broken out by
 | Date | DOI / slug | Vendor | Topic |
 | --- | --- | --- | --- |
 | 2026-08-16 | **Quintard 2024 Nat Commun + Guo 2026 Front Cell Dev Biol 7-commit LDR cluster** (commits `0fc8db24` + `290e9635` + `24c713de` + `4073abf4` Quintard + `2e6f5989` + `00f824f2` + `a4fa5a32` Guo) | **CelVivo adjacent + Mimetas OrganoPlate ⭐⭐⭐⭐ + Emulate Organ-Chip ⭐⭐⭐** (Quintard) / **CelVivo ClinoStar ⭐⭐⭐⭐ + Mimetas OrganoPlate ⭐⭐⭐⭐ + Emulate Organ-Chip ⭐⭐⭐** (Guo) | Quintard C et al. (2024) A microfluidic platform integrating functional vascularized organoids-on-chip (Nat Commun DOI 10.1038/s41467-024-45710-4, Wiki ID 1719/1720/1722, NocoDB Id 3297; 10 通道并行微流控 + hiPSC-BVO 30 天功能性灌注培养 + 跨类器官验证 [间充质球体 / BVO / 胰岛球体 / 肺类器官]; 血管层级化 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管, 壁剪切 27-2000 s⁻¹, 完美匹配人体毛细血管生理范围 50-1900 s⁻¹) + Guo Z & Zhang N (2026) Ethical review key considerations for organoid applications in biomedical research—a systematic review (Front Cell Dev Biol DOI 10.3389/fcell.2026.1721946, Wiki ID 1724, NocoDB Id 3298; 嘉兴市第一医院 + 嘉兴大学医学院视角; 类器官研究 IRB / 伦理审查 7 大强制要点系统综述 [样本来源/知情同意/数据隐私/共培养主体性/3R 动物福利/跨境监管/长期保存与终止使用] + 中国《人类遗传资源管理条例》+ 国际 ISSCR/GDPR/HIPAA 多国对照表). **Robin translated Guo 2026 into a customer-facing IRB application checklist template** (`templates/类器官IRB申请清单.md` v1.0 180 lines) — first customer-facing template produced from a single deep-read. |
 | 2026-08-12 | **Liang 2026 liver organoid fibrosis platform 4-commit LDR cycle** (commits `e542c977` + `8699a154` + `aacba7aa` + `297f106d`) | **CelVivo (ClinoStar rating 5 + ClinoReactor rating 5)** | Liang Y et al. (2026) A robust mouse liver organoid platform enables sustained multicellular maturation and fibrosis modeling from a single tissue sample (Sci Rep DOI 10.1038/s41598-026-42990-2, PMID 41857098; Wiki.js Id 1716, NocoDB Id 770; 3 轨道 Hep-Orgs + Cho-Orgs + HSC 同步分离; DAPT+Dex P1-P10 长程稳定成熟 [ALB/PAS/LDL/CYP 跨代保持]; TGFβ 激活 qHSC → aHSC [Acta2/Col1a1 上调]; aHSC 共培养诱导 Hep-Orgs EMT [Snail/Twist/Vimentin↑; ALB/CK8↓; Lgr5/EpCAM↓; Ki67↓] = 体外肝纤维化模型) — page 946 9 项 SOP 重写版 + page 934 修齐 标杆; 7/7 Ollama qwen2.5vl 视觉审核通过; SeaFile 7/7 公网 200 验真. First paper whose `related:` field already names `[[MOC-类器官与3D培养]]` (the 2026-08-10 first MOC) on the day of publication. |
 | 2026-08-10 | **Phase A metadata batch + first MOC** (commits `d97b39ed` + `6b717aef` + `3b929c2f`) | (process discipline) | 6 deep-reads received the 6-field frontmatter (doi/journal/year/volume/pages/authors/pmid); first MOC `MOC-类器官与3D培养.md` (95 lines, 沙牛《AI 时代的 Obsidian 公开课》课时 1 pattern) created at `04-Literature/Deep-Reads/MOCs/`; 7 image alt descriptions added on `wang2024-org-on-chip.md`. No new external evidence. |
 | 2026-08-09 | `10.7150/thno.90492` (Wang 2024) | (4 类共性硬件 — Organoid-on-Chip 综述) | Wang H et al. (2024) Human organoids-on-chips for biomedical research and applications (Theranostics 14(2):788-818, PMID 38169573; 7 图覆盖 7 大主题板块) — Wiki.js ID 1700 (v2 - grp:3 ghost page 累加) |
@@ -214,16 +220,18 @@ From [`/sources/literature.md`](/sources/literature.md) last sync, broken out by
 By vendor (30-day mtime):
-| Vendor | Most recent | 2026-08-08 / 2026-08-10 / 2026-08-12 additions |
+| Vendor | Most recent | 2026-08-08 / 2026-08-10 / 2026-08-12 / 2026-08-16 additions |
 | --- | --- | --- |
-| CelVivo | 2026-08-12 (Liang 2026 — ClinoStar rating 5 + ClinoReactor rating 5) | +Liang 2026 (P1-P10 长程成熟 + 单组织 3 轨道分通道灌流 + TGFβ 时间程序精确切换 — liver organoid fibrosis platform), +Miao 2025 v2 (ClinoStar co-differentiation), +Sharma 2026 (ClinoStar rating 3 adjacent), +Liu 2026 (ClinoStar rating 4 adjacent) |
+| CelVivo | 2026-08-12 (Liang 2026 — ClinoStar rating 5 + ClinoReactor rating 5) | +Liang 2026 (P1-P10 长程成熟 + 单组织 3 轨道分通道灌流 + TGFβ 时间程序精确切换 — liver organoid fibrosis platform), +Miao 2025 v2 (ClinoStar co-differentiation), +Sharma 2026 (ClinoStar rating 3 adjacent), +Liu 2026 (ClinoStar rating 4 adjacent), +Quintard 2024 (CelVivo ClinoStar rating 3 — upstream workflow step: BVO day 0-15 needs rotating-wall suspension culture), +Guo 2026 (CelVivo ClinoStar rating 4 — clinical-translation IRB compliance for 三甲医院 客户) |
-| 3Brain | 2026-08-08 (Liu 2026 — HD-MEA rating 5) | +Liu 2026 (shape-conformal framework, next-gen HD-MEA), +Sharma 2026 (HD-MEA rating 4 adjacent), +Shin 2024 (Phase A frontmatter hygiene on existing note) |
+| 3Brain | 2026-08-08 (Liu 2026 — HD-MEA rating 5) | +Liu 2026 (shape-conformal framework, next-gen HD-MEA), +Sharma 2026 (HD-MEA rating 4 adjacent), +Shin 2024 (Phase A frontmatter hygiene on existing note), **−3Brain reference removed from Quintard 2024 -v4 (per commit `4073abf4` — "精读 Quintard 2024 -v4 (转发语标题/落款加粗/删3Brain)" was the explicit SOP rule "硬门槛合规修正" cleanup; Quintard is vendor-adjacent CelVivo/Mimetas/Emulate rather than 3Brain territory)** |
-| Cellink | 2026-07-27 (Tasevska 2025) | +Liu 2026 (microlattice fabrication rating 5 adjacent) |
+| Cellink | 2026-07-27 (Tasevska 2025) | +Liu 2026 (microlattice fabrication rating 5 adjacent), **+Quintard 2024 (microfluidic organ-on-chip adjacent, no direct Cellink rating — but the platform architecture is a candidate cross-sell with Cellink BIO X for vascularized scaffold fabrication)** |
 | Adjacent (no vendor) | 2026-08-08 (Sharma 2026 retinal vascularization) | +Sharma 2026 (retinal organoid application domain) |
 | (Process discipline) | 2026-08-10 (Phase A batch + first MOC) | +6 deep-reads received 6-field frontmatter; +first MOC `MOC-类器官与3D培养.md` created; +7 image alt descriptions on Wang 2024 — no new external evidence |
 | (Subfolder expansion, uncommitted) | 2026-08-13 (new `Review/` subfolder) | +1 untracked file `Review/zhou2023_computer_vision_microfluidics.md` (first review-type subfolder — review papers stream separately from original research) |
 | (Customer-facing template, uncommitted) | 2026-08-16 (new `templates/` subfolder + IRB application checklist v1.0) | +1 untracked file `templates/类器官IRB申请清单.md` 180 lines (Guo 2026 ethics deep-read → IRB checklist template; 7 mandatory points + 5 customer Q&A + China vs International flow + 10 attachments + 7 citations; Robin's first customer-facing template produced from a single deep-read; will route into CelVivo industrial-customers program once committed) |
 | (Commercial quote PDF, untracked) | 2026-08-17 (new `celvivo_commercial/` subfolder) | +1 untracked file `celvivo_commercial/1331651_20260630_131201.pdf` (6-30 quote PDF migrated into a new folder; companion to the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree) |
-The pipeline is **vendor-balanced** — CelVivo, 3Brain, Cellink each have a recent deep read, and the 2026-08-08 flywheel-sync adds **3 papers spanning all 3 primary vendors + the retinal organoid application domain** (Sharma), all 3 rated 4-5 on at least one vendor's product line. The 2026-08-10 cluster is **process discipline** (Phase A metadata batch + first MOC creation + Wang 2024 alt-description sample), not new external evidence — the 6 deep-reads already existed on `main`; the 3 commits only normalize their metadata and add a knowledge-graph index layer. The 2026-08-12 cluster adds **net-new external evidence**: Liang 2026 Sci Rep liver organoid fibrosis platform (4-commit LDR cycle on a single paper, CelVivo ClinoStar ⭐⭐⭐⭐ + ClinoReactor ⭐⭐⭐⭐); this is the **first paper on `main` whose `related:` field already names `[[MOC-类器官与3D培养]]` on the day of publication**, confirming the MOC pattern is in active use on real deep-reads (vs the prior 2026-08-10 "MOC `related:` lists future MOCs" framing which was only prospective). The **first entry in the new NocoDB table `Robin_Picked_Papers`** is Liu 2026 (created 2026-08-08 per Robin instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage). The **first MOC** `MOC-类器官与3D培养.md` is the start of a Map-of-Content layer Robin appears to be building (the MOC's own `related:` already names `[[MOC-3Brain-HD-MEA]]` as the next planned MOC). The 2026-08-13 cluster (no vault commits, 1 new untracked file) **adds a new `Review/` subfolder to the deep-read tree** — Robin appears to be expanding the folder taxonomy to separate review-type papers from original-research papers; whether this is a one-off subfolder or the start of a recurring folder pattern is a watchlist item for the next git-repo fetch.
+The pipeline is **vendor-balanced** — CelVivo, 3Brain, Cellink each have a recent deep read, and the 2026-08-08 flywheel-sync adds **3 papers spanning all 3 primary vendors + the retinal organoid application domain** (Sharma), all 3 rated 4-5 on at least one vendor's product line. The 2026-08-10 cluster is **process discipline** (Phase A metadata batch + first MOC creation + Wang 2024 alt-description sample), not new external evidence — the 6 deep-reads already existed on `main`; the 3 commits only normalize their metadata and add a knowledge-graph index layer. The 2026-08-12 cluster adds **net-new external evidence**: Liang 2026 Sci Rep liver organoid fibrosis platform (4-commit LDR cycle on a single paper, CelVivo ClinoStar ⭐⭐⭐⭐ + ClinoReactor ⭐⭐⭐⭐); this is the **first paper on `main` whose `related:` field already names `[[MOC-类器官与3D培养]]` on the day of publication**, confirming the MOC pattern is in active use on real deep-reads (vs the prior 2026-08-10 "MOC `related:` lists future MOCs" framing which was only prospective). The **first entry in the new NocoDB table `Robin_Picked_Papers`** is Liu 2026 (created 2026-08-08 per Robin instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage). The **first MOC** `MOC-类器官与3D培养.md` is the start of a Map-of-Content layer Robin appears to be building (the MOC's own `related:` already names `[[MOC-3Brain-HD-MEA]]` as the next planned MOC). The 2026-08-13 cluster (no vault commits, 1 new untracked file) **adds a new `Review/` subfolder to the deep-read tree** — Robin appears to be expanding the folder taxonomy to separate review-type papers from original-research papers; whether this is a one-off subfolder or the start of a recurring folder pattern is a watchlist item for the next git-repo fetch. **The 2026-08-16 cluster (Quintard 2024 + Guo 2026) is the largest single-window vault delta since the 2026-07-28 / 2026-07-29 cluster** — 7 new vault commits spanning 2 new paper deep-reads, 2 new untracked working-tree directories, and 1 customer-facing sales-ammunition template derived from a single deep-read. The Quintard 2024 microfluidic / organ-on-chip platform (CelVivo ClinoStar upstream + Mimetas OrganoPlate direct competitor + Emulate Organ-Chip) extends Robin's vendor mapping into the organ-on-chip product lane that his portfolio doesn't currently cover; the Guo 2026 organoid ethics systematic review (7 mandatory points + 5 jurisdiction comparison) introduces the IRB / ethics domain to Robin's deep-read set and spawned `templates/类器官IRB申请清单.md` (180 lines, Robin's first customer-facing template) as the canonical "Robin 培训客户 IRB 申请" core material. The new `templates/` + `celvivo_commercial/` directories appear alongside the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree — Robin may be formalizing customer-facing deliverables (checklists / templates / sales scripts) as a separate vault subtree. The `Review/zhou2023_computer_vision_microfluidics.md` carry-forward untracked file is still-uncommitted at this fetch (now 4 days past the 2026-08-13 first observation); the watchlist trigger is if it remains uncommitted at the next fetch.
 ## Sales ammunition pipeline
@@ -237,6 +245,8 @@ Robin maintains a working sales library that consumes LDR output and routes into
 Cross-link to the canonical synthesis: [`/sources/sales-ammunition.md`](/sources/sales-ammunition.md).
 **2026-08-16 addition — `templates/类器官IRB申请清单.md` v1.0** (180 lines, Robin 8-16 实战沉淀, **untracked**; derived from Guo 2026 Front Cell Dev Biol IRB / ethics systematic review — Wiki.js ID 1724, NocoDB Id 3298). The IRB application checklist is **Robin 第一份 customer-facing template produced from a single deep-read** and consists of: (a) **7 强制要点** [样本来源合法性 + 捐赠者知情同意 + 数据隐私与去标识化 + 共培养产物主体性评估 + 动物福利 3R + 跨境监管合规 + 长期保存与终止使用]; (b) **5 customer Q&A** [类器官研究是否要 IRB 申请 / 类器官共培养产品怎么申请 IRB / 类器官跨境研究怎么报 / 3R 原则怎么写 / 类器官 + 免疫细胞共培养 = CAR-T 体外培养, 算不算新生物体]; (c) **China vs International flow comparison table** [中国 2023 新规 vs 美国 Common Rule vs 欧盟 GDPR]; (d) **10 申请附件清单** [IRB 申请表 + 知情同意书 + 研究方案 + DMP + 样本采集机构 IRB 批件 + ...]; (e) **7 引用** [Guo 2026 + ISSCR 2021 + OHRP 2016 + GDPR + 中国 2023 + 中国 2019 + Cambridge 2020]. **Vendor relevance**: CelVivo ClinoStar ⭐⭐⭐⭐ (the 7 mandatory points directly apply to ClinoStar customer IRB submissions; **Robin 推广 ClinoStar 给三甲医院时, 可附带本框架作为增值**). Tracks as `/commitments.md` `guo-2026-organoid-irb-checklist-rollout` (Owner: me; fold IRB application checklist into CelVivo industrial-customers program + Robin customer-training core material; commit `templates/类器官IRB申请清单.md` and add a synthesis page at `/sources/literature-guo-2026-front-cell-dev-biol-organoid-ethics-deepread.md`).
 ## Sales training cluster (working-tree additions)
 Per `/sources/git-repo.md` §"Notable entities", `06-Sales/Content/Training-Materials/` contains the following working-tree additions not yet on `main`:
@@ -307,6 +317,8 @@ A dedicated subfolder under `05-Documents/Products/Celvivo/Industrial-Customers/
 This is a self-contained CelVivo China commercial effort. The latest mtime census (2026-07-16 snapshot) shows `CelVivo_中国工业客户开发研究报告_20260626_v2.md` as the most-recent file (18 KB, 06-26 11:52). Documented at [`/sources/git-repo.md`](/sources/git-repo.md) §Notable entities.
 **2026-08-17 working-tree addition — `celvivo_commercial/1331651_20260630_131201.pdf`** (56 KB, 2026-06-30 quote PDF migrated into a new folder; **untracked**) — companion to the existing `05-Documents/Products/Celvivo/Industrial-Customers/` commercial-docs subtree. The new folder name signals Robin may be consolidating "Celvivo commercial" documents into a separate vault subtree rather than continuing to nest them under `05-Documents/Products/Celvivo/Industrial-Customers/` (which is the prior convention). If the convention holds, future CelVivo commercial PDFs / quotes / pricing tables will land in `celvivo_commercial/` instead of `05-Documents/Products/Celvivo/Industrial-Customers/`; if it doesn't hold, it's a one-off folder for the 6-30 quote. Watchlist trigger: if a second PDF or commercial doc lands in `celvivo_commercial/` by the next git-repo fetch, the convention change is real; if it stays single-entry, it's a one-off.
 ## Work-rhythm snapshot (2026-07-16)
 From [`/sources/vault-mtime-snapshot-2026-07-16.md`](/sources/vault-mtime-snapshot-2026-07-16.md) (last full mtime census):
@@ -398,4 +410,8 @@ These are source-anchored but not vendor-anchored — they live here for traceab
 | How does the agent stack consume this output? | [`/themes/03-ai-agents.md`](/themes/03-ai-agents.md) |
 | How does the local-LLM fleet host this evidence? | [`/themes/04-local-llm.md`](/themes/04-local-llm.md) |
 | Where does CelVivo + 3Brain output land? | [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) |
-| Where does Cellink output land? | [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md) ||
+| Where does Cellink output land? | [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md) |
 | What does Quintard 2024 say about vascularized organoid chips? | `obsidian-vault/Literature/Deep-Reads/Organoid/quintard_2024_vasorganoid_chip.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
 | What does Guo 2026 say about organoid IRB ethics? | `obsidian-vault/Literature/Deep-Reads/Organoid/guo_2026_organoid_ethical_review.md` (vault path; deep-read synthesis not yet split out to `/sources/`) |
 | What's the IRB application checklist for organoid research? | `templates/类器官IRB申请清单.md` v1.0 (vault path; untracked) ||th; deep-read synthesis not yet split out to `/sources/`) |
 | What's the IRB application checklist for organoid research? | `templates/类器官IRB申请清单.md` v1.0 (vault path; untracked) ||
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