openwiki-wiki/themes.md

Themes

Recurring topics, signals, and trends observed across Robin's sources. Detailed evidence and item lists live on the relevant /sources/<connector>.md or topic page; this file is the index.

Index kept narrow by design: only themes that map to Robin's actual work (life-sciences PM at Femtobiomed / 9X Bio, CelVivo / 3Brain / Cellink / Femtobiomed product portfolio, plus the AI agent tooling stack that drives his daily workflow). High-engagement HN topics outside this scope are noted in /sources/hackernews.md under "Themes not refreshed this run" but are not promoted to theme rows here.

Topic key	Theme / Signal	First seen	Last seen	Confidence	Sources	Evidence count	Status	Evidence
class-organoid-3d-bioprinting	Recurring organoid, 3D bioprinting, and 3D-cell-culture automation coverage; this window adds Nature evidence on standardized liver-spheroid workflows and organ-on-chip pharmacomicrobiomics, still application-level rather than vendor launches	2026-07-16	2026-07-26	source-backed	hackernews, web-search	14+	active	HN cluster; Tavily evidence
china-cde-cell-gene-therapy-rules-2026	China CDE (under NMPA) published technical guidelines defining scope & classification of cell and gene therapy drugs; standardizes CMC planning for Chinese pharma/CDMO/biotech customers	2026-07-24	2026-07-24	source-backed	web-search	1	watchlist	Tavily: cisema.com 2026-07-24
MiniMax-m3	MiniMax-M3 (1M context multimodal) HuggingFace model card + Twitter launch; the daily-driver inference provider behind every OpenWiki run and most of Robin's agent work; haimaker.ai July 2026 third-party eval ranks models for Hermes Agent usage	2026-07-16	2026-07-23	watchlist	hackernews, web-search	3	watchlist	HN: M3 model cluster (huggingface + twitter); Tavily: Hermes Agent best-models eval
openwiki-brand	langchain-ai/openwiki (96 pts) — same product family as Robin's OpenWiki; high-engagement on HN	2026-07-16	2026-07-16	source-backed	hackernews	1 (+ 2 adjacent wrappers)	watchlist	HN: openwiki cluster
agent-memory-architecture	Show HN items on structured memory / trust layers for agents (Worklog SQLite, Open Knowledge format v0.2, Assumption Ledger) — directly adjacent to OpenWiki's role	2026-07-26	2026-07-26	watchlist	hackernews	3	watchlist	HN: 49059959, 49059889, 49060215

Notes

• Promote a watchlist signal to a full theme row only after it recurs or comes from a high-quality source.
• Keep prose here to 1-2 sentences per theme; link out for detail.
• HN evidence rules: low-engagement items are watchlist by default; promotion requires recurrence, strong engagement, or corroboration.
• Scope discipline (per ~/.openwiki/INSTRUCTIONS.md): themes that do not anchor to one of (a) the 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed), (b) Robin's active customers, (c) the 4 application domains (3D cell culture, 3D bioprinting, neuroscience in vitro, organoid workflows), or (d) the daily-driver AI agent stack (Hermes Agent, MiniMax, OpenWiki, RAGFlow, NocoDB, SeaFile) → drop from this index even when HN engagement is high.
• Topic rows like coding-agent-tooling, context-engineering-claude5, ai-safety-debate, open-weight-ai, computer-use-agents, codex-openai, llm-on-old-hardware, local-LLM-stream are deliberately absent here. Their evidence lives in /sources/hackernews.md for traceability but they do not earn a themes.md row.
• Vendor brand signal: CelVivo, 3Brain, Cellink, ClinoStar, ClinoReactor, Femtobiomed CellShot/CellPick/TriArm still have no material Hacker News footprint (see /sources/hackernews.md query-hit table). The web-search connector (Tavily) is the better lane for these — see /sources/web-search.md for the first pull on 2026-07-26.