---
type: "Reference"
title: "Literature Deep-Reads — 跨 agent 精读索引"
openwiki_generated: true
---

# Literature Deep-Reads — 跨 agent 精读索引

> 数据源: Obsidian vault `04-Literature/Deep-Reads/<vendor>/<DOI>.md` (git-repo connector 自动同步)
> 用途: MiniMax code / Hermes 跨 agent 检索 "Robin 最近精读了什么文献"
> 更新: OpenWiki cron 每天 02:00 自动扫 vault mtime, 增量更新本文件

## 最近 30 天精读 (按 mtime 倒序)

### 2026-08-08
| DOI | Vendor | 类器官 | 标题 | 路径 |
|---|---|---|---|---|
| `10.1016/j.stem.2025.12.013` | (无 vendor, Research) | 视网膜类器官 | Sharma K et al. (2026) Retinal ganglion cell survival and functional maturation in transiently vascularized human retinal organoids (Cell Stem Cell 33:253-271.e13, PMID 41529691, vRO 第18周 RGC 18.2% vs ctrl-RO 1.21% p<0.001, 第31周 ON/OFF/ON-OFF 光响应) | `Retina-StemCell/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc.md` |

### 2026-07-29
| DOI | Vendor | 类器官 | 标题 | 路径 |
|---|---|---|---|---|
| `10.1186_s40164-026-00743-x` | (无 vendor, 综述) | 全谱综述 | Organoids for disease modeling and treatment: state-of-the-art (Exp Hematol Oncol 2026, PMID 41545895, 190 项临床试验 + 4 大瓶颈) | `Organoid/2026-07-29_Organoids_disease_modeling_treatment_2026_review.md` |

### 2026-07-28
| DOI | Vendor | 类器官 | 标题 | 路径 |
|---|---|---|---|---|
| `10.1080_17460751.2025.2572177` | Ronawk Bio-Block (KB 0 命中) | MSC / 脂肪源 | Comparison of 3D culture systems on MSC longevity, regenerative potential, and secretome production | `RegenMed/2026-07-28_Hodge_2025_RegenMed_MSC_3D_Bio-Block.md` |
| `10.3389/fvets.2025.1500267` | (无 vendor) | 犬脂肪 MSC 3D 球体 | Lee E et al. (2025) Enhanced immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells in 3D culture (Front Vet Sci 12:1500267, ULA 板 48h, 3D CM 显著压低 LPS-DH82 M1 p<0.0001) | `Other/2026-07-28_Lee_2025_FrontVetSci_canine_MSC_3D_spheroid.md` |

### 2026-07-17
| DOI | Vendor | 类器官 | 标题 | 路径 |
|---|---|---|---|---|
| `260528_appnote` | CelVivo | 通用 | Influence of shear stress on long-term 3D construct performance: Comparison of orbital shaker and ClinoStar system (vs 竞品杀手文档) | `Celvivo/260528_CS_versus_OS_appnote_2026-07-17.md` |
| `111_appnote` | CelVivo | 球体量化 | Planimetry measurements of spheroids in a ClinoReactor using FIJI - Application Note | `Celvivo/111_Planimetry_ClinoReactor_FIJI_2026-07-17.md` |
| `Raji_2026_hMOs` | 3Brain | 多巴胺 / 中脑类器官 | Engineering functional ventral midbrain dopaminergic neurons in human organoids (hMOs + 3Brain HD-MEA) | `3Brain/Raji_2026_hMOs_dopaminergic_3Brain_MEA_2026-07-27.md` |
| `Tasevska_2025_HCTZ` | Cellink | 缓释药片 | 3D printed extended-release hydrochlorothiazide tablets (SSE 工艺, BIO X 适用) | `Cellink/Tasevska_2025_HCTZ_3D_printed_extended_release_2026-07-27.md` |

### 2026-07-05
| DOI | Vendor | 类器官 | 标题 | 路径 |
|---|---|---|---|---|
| `10.1002_btpr.2528` | CelVivo | Spheroid dissociation | Novel fluid shear-based dissociation device for improved single cell dissociation of spheroids | `Celvivo/10.1002_btpr.2528.md` |

### 2026-06-25 (2 篇)
| DOI | Vendor | 类器官 | 标题 | 路径 |
|---|---|---|---|---|
| `10.1016_j.stemcr.2025.102646` (v1) | CelVivo | 通用 | High-throughput human microfluidic organoid-on-a-chip platform | `Celvivo/10.1016_j.stemcr.2025.102646.md` |
| `10.1016_j.stemcr.2025.102646_v2` | CelVivo | 通用 | 同上 v2 (重写) | `Celvivo/10.1016_j.stemcr.2025.102646_v2.md` |

### 2026-06-24 (2 篇)
| DOI | Vendor | 类器官 | 标题 | 路径 |
|---|---|---|---|---|
| `10.1021_acsomega.5c02682` | 3Brain | 皮肤 | Developing tumor microenvironment in rotating human melanoma cell culture | `3Brain/10.1021_acsomega.5c02682.md` |
| `10.1016_j.xpro.2025.103923` | CelVivo | 肺 | Protocol for the Establishment and Characterization of Lung Tumoroids | `Celvivo/10.1016_j.xpro.2025.103923.md` |

### 2026-06-23 (2 篇)
| DOI | Vendor | 类器官 | 标题 | 路径 |
|---|---|---|---|---|
| `10.1002_jbm4.10792` | CelVivo | 通用 | High-throughput microfluidic organoid-on-a-chip (v2-munir2023) | `Celvivo/10.1002_jbm4.10792-v2-munir2023.md` |
| `10.3390_cells11203216` | CelVivo | 肝 NAFLD | Mapping Proteome and Lipidome Changes in Early-Onset NAFLD | `Celvivo/10.3390_cells11203216.md` |

## 按 Vendor 统计 (mtime 2026-06-16 → 2026-07-28)

| Vendor | 30 天精读数 | 最近一篇 |
|---|---|---|
| **CelVivo** | 5 篇 | 2026-07-05 |
| **3Brain** | 1 篇 | 2026-06-24 |
| **Cellink** | 1 篇 | 2026-07-27 |
| **Ronawk Bio-Block** (KB 0 命中) | 1 篇 | 2026-07-28 |

## 4 周 MSC 长期培养关键词命中 (累计)

- `Bio-Block Ronawk 3D culture mesenchymal` (2026-07-28 入库, **未 KB 验证**; 4 周时窗 vs 2D/球体/Matrigel 平台对比)
- `Hodge Mellott Bio-Block 3D culture` (2026-07-28 入库, **未 KB 验证**; 同上 Ronawk 团队 USC Kansas)

## ClinoReactor 关键词命中 (累计)

- `Planimetry measurements of spheroids in a ClinoReactor using FIJI` (2026-04-01 入库, **未精读**)

## 跟 OpenWiki 其他源的关系

| 源 | 看什么 |
|---|---|
| **本文件** (literature.md) | 精读笔记 (本文件) |
| `sources/hackernews.md` | 外部公开讨论 |
| `sources/git-repo.md` | vault 整体结构 |
| `commitments.md` | Robin 任务承诺 |
| `themes.md` | 跨源主题综合 |

## 触发查询示例 (MiniMax code 用)

- "Robin 最近精读了哪些 CelVivo 文献" → 读本文件 CelVivo 段
- "ClinoReactor 相关最新研究" → 读本文件 ClinoReactor 段 + ClinoReactor 关键词命中
- "近一周有什么新文献" → 读本文件 "最近 7 天" 段

## 维护方式

- **手动触发**: 通知 Robin "更新 literature 索引"
- **自动**: OpenWiki cron 每天 02:00 跑 git-repo connector, 写本文件
- **路径**: `~/.openwiki/wiki/sources/literature.md` (同步推 Gitea)
### 2026-07-28
| DOI | Vendor | 类器官 | 标题 | 路径 |
|---|---|---|---|---|
| `10.1080_17460751.2025.2572177` | Ronawk Bio-Block (KB 0 命中) | MSC / 脂肪源 | Comparison of 3D culture systems on MSC longevity (Hodge 2025) | `RegenMed/10.1080_17460751.2025.2572177.md` |
| `10.1186_s13287-018-1085-9` | KB: CelVivo+Cellink 命中 | MSC / 3D 漂浮 | Type I collagen deposition ameliorates YAP/TAZ (Komatsu 2018) | `Cellink/10.1186_s13287-018-1085-9.md` |
| `10.3389_fvets.2025.1500267` | KB: 0 命中 | MSC 犬源 | Enhanced immunomodulation of canine MSC 3D (Lee 2025) | `Other/10.3389_fvets.2025.1500267.md` |
| `10.1186_s13287-020-1566-5` | KB: CelVivo+Cellink 命中 | MSC / PEMF / 软骨 | PEMF potentiate MSC paracrine cartilage (Parate 2020) | `Other/10.1186_s13287-020-1566-5.md` |

### 2026-08-04 (ITX 端 hermes test)
| DOI | Vendor | 类器官 | 标题 | 路径 |
|---|---|---|---|---|
| `10.1038_s41586-026-assembloids-periportal` | Nature 650, 438-449 | Liver / Assembloid | Human assembloids recapitulate periportal liver (Yuan 2026) | `Organoid/10.1038_s41586-026-assembloids-periportal.md` |

### 2026-08-08
| 10.1016/j.cell.2025.05.041 | Miao 2025 Cell - 共分化中胚层-内胚层实现类器官血管化 | Cell | 2025 | https://wiki.biokingdom.top/zh/literature/miao-2025-cell-organoid-vascularization-v2 |

### 2026-08-08
| 10.1038/s41551-026-01620-y | Liu 2026 Nat Biomed Eng - Shape-conformal porous frameworks for neural organoids + HD-MEA electrophysiology | Nature Biomedical Engineering | 2026 | https://wiki.biokingdom.top/zh/literature/liu-2026-nbme-shape-conformal-organoid-final |