# Literature Deep-Reads — 跨 agent 精读索引

> 数据源: Obsidian vault `04-Literature/Deep-Reads/<vendor>/<DOI>.md` (git-repo connector 自动同步)
> 用途: MiniMax code / Hermes 跨 agent 检索 "Robin 最近精读了什么文献"
> 更新: OpenWiki cron 每天 02:00 自动扫 vault mtime, 增量更新本文件

## 最近 30 天精读 (按 mtime 倒序)

### 2026-07-28
| DOI | Vendor | 类器官 | 标题 | 路径 |
|---|---|---|---|---|
| `10.1080_17460751.2025.2572177` | Ronawk Bio-Block (KB 0 命中) | MSC / 脂肪源 | Comparison of 3D culture systems on MSC longevity, regenerative potential, and secretome production | `RegenMed/2026-07-28_Hodge_2025_RegenMed_MSC_3D_Bio-Block.md` |

### 2026-07-17
| DOI | Vendor | 类器官 | 标题 | 路径 |
|---|---|---|---|---|
| `260528_appnote` | CelVivo | 通用 | Influence of shear stress on long-term 3D construct performance: Comparison of orbital shaker and ClinoStar system (vs 竞品杀手文档) | `Celvivo/260528_CS_versus_OS_appnote_2026-07-17.md` |
| `111_appnote` | CelVivo | 球体量化 | Planimetry measurements of spheroids in a ClinoReactor using FIJI - Application Note | `Celvivo/111_Planimetry_ClinoReactor_FIJI_2026-07-17.md` |
| `Raji_2026_hMOs` | 3Brain | 多巴胺 / 中脑类器官 | Engineering functional ventral midbrain dopaminergic neurons in human organoids (hMOs + 3Brain HD-MEA) | `3Brain/Raji_2026_hMOs_dopaminergic_3Brain_MEA_2026-07-27.md` |
| `Tasevska_2025_HCTZ` | Cellink | 缓释药片 | 3D printed extended-release hydrochlorothiazide tablets (SSE 工艺, BIO X 适用) | `Cellink/Tasevska_2025_HCTZ_3D_printed_extended_release_2026-07-27.md` |

### 2026-07-05
| DOI | Vendor | 类器官 | 标题 | 路径 |
|---|---|---|---|---|
| `10.1002_btpr.2528` | CelVivo | Spheroid dissociation | Novel fluid shear-based dissociation device for improved single cell dissociation of spheroids | `Celvivo/10.1002_btpr.2528.md` |

### 2026-06-25 (2 篇)
| DOI | Vendor | 类器官 | 标题 | 路径 |
|---|---|---|---|---|
| `10.1016_j.stemcr.2025.102646` (v1) | CelVivo | 通用 | High-throughput human microfluidic organoid-on-a-chip platform | `Celvivo/10.1016_j.stemcr.2025.102646.md` |
| `10.1016_j.stemcr.2025.102646_v2` | CelVivo | 通用 | 同上 v2 (重写) | `Celvivo/10.1016_j.stemcr.2025.102646_v2.md` |

### 2026-06-24 (2 篇)
| DOI | Vendor | 类器官 | 标题 | 路径 |
|---|---|---|---|---|
| `10.1021_acsomega.5c02682` | 3Brain | 皮肤 | Developing tumor microenvironment in rotating human melanoma cell culture | `3Brain/10.1021_acsomega.5c02682.md` |
| `10.1016_j.xpro.2025.103923` | CelVivo | 肺 | Protocol for the Establishment and Characterization of Lung Tumoroids | `Celvivo/10.1016_j.xpro.2025.103923.md` |

### 2026-06-23 (2 篇)
| DOI | Vendor | 类器官 | 标题 | 路径 |
|---|---|---|---|---|
| `10.1002_jbm4.10792` | CelVivo | 通用 | High-throughput microfluidic organoid-on-a-chip (v2-munir2023) | `Celvivo/10.1002_jbm4.10792-v2-munir2023.md` |
| `10.3390_cells11203216` | CelVivo | 肝 NAFLD | Mapping Proteome and Lipidome Changes in Early-Onset NAFLD | `Celvivo/10.3390_cells11203216.md` |

## 按 Vendor 统计 (mtime 2026-06-16 → 2026-07-28)

| Vendor | 30 天精读数 | 最近一篇 |
|---|---|---|
| **CelVivo** | 5 篇 | 2026-07-05 |
| **3Brain** | 1 篇 | 2026-06-24 |
| **Cellink** | 1 篇 | 2026-07-27 |
| **Ronawk Bio-Block** (KB 0 命中) | 1 篇 | 2026-07-28 |

## 4 周 MSC 长期培养关键词命中 (累计)

- `Bio-Block Ronawk 3D culture mesenchymal` (2026-07-28 入库, **未 KB 验证**; 4 周时窗 vs 2D/球体/Matrigel 平台对比)
- `Hodge Mellott Bio-Block 3D culture` (2026-07-28 入库, **未 KB 验证**; 同上 Ronawk 团队 USC Kansas)

## ClinoReactor 关键词命中 (累计)

- `Planimetry measurements of spheroids in a ClinoReactor using FIJI` (2026-04-01 入库, **未精读**)

## 跟 OpenWiki 其他源的关系

| 源 | 看什么 |
|---|---|
| **本文件** (literature.md) | 精读笔记 (本文件) |
| `sources/hackernews.md` | 外部公开讨论 |
| `sources/git-repo.md` | vault 整体结构 |
| `commitments.md` | Robin 任务承诺 |
| `themes.md` | 跨源主题综合 |

## 触发查询示例 (MiniMax code 用)

- "Robin 最近精读了哪些 CelVivo 文献" → 读本文件 CelVivo 段
- "ClinoReactor 相关最新研究" → 读本文件 ClinoReactor 段 + ClinoReactor 关键词命中
- "近一周有什么新文献" → 读本文件 "最近 7 天" 段

## 维护方式

- **手动触发**: 通知 Robin "更新 literature 索引"
- **自动**: OpenWiki cron 每天 02:00 跑 git-repo connector, 写本文件
- **路径**: `~/.openwiki/wiki/sources/literature.md` (同步推 Gitea)