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@@ -178,9 +178,49 @@ The `Robin_Picked_Papers` table is **new as of today** — created per Robin's 2
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- **Authors**: Yang J, Zhang X, Li S, Gao Z
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- **Authors**: Yang J, Zhang X, Li S, Gao Z
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- **Journal**: Cells 2026, 15(8), 703 (MDPI, IF ~5.1, CC-BY OA)
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- **Journal**: Cells 2026, 15(8), 703 (MDPI, IF ~5.1, CC-BY OA)
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- **DOI**: 10.3390/cells15080703
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- **DOI**: 10.3390/cells15080703
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- **Wiki.js**: [ID 1708](https://hb.biokingdom.top/wiki/organoid/ovb-cerebral-organoid-multiscale-2026)
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- **Wiki.js**: [ID 1708](http://10.10.10.254:3000/zh/organoid/ovb-cerebral-organoid-multiscale-2026)
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- **NocoDB Id**: 1103
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- **NocoDB Id**: 1103
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- **PDF**: SeaFile 文献库 7 张整页配图(qwen2.5vl:7b 视觉审核通过)
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- **PDF**: [cells_15_00703.pdf](https://fb.biokingdom.top/f/582d1f055f6e4365a924/?raw=1) + 10 张真实配图(xref extract)
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- **Key finding**: 首次标准化 OVB-类器官(视泡-大脑)vs 大脑类器官多尺度对比;Day 30 FOXG1+VSX2 共表达;TEM 突触+髓鞘;1,625/2,924 DEGs
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- **Key finding**: Cells 2026 重磅 - OVB-organoids vs Cerebral 多尺度对比(中国军事医学科学院); Day 30 FOXG1+53.86% + VSX2+4.18%; TEM 突触+髓鞘; 1625 上调 + 2924 下调 DEGs; CHRNB2 6.5 倍差异; KEGG 富集到神经突触功能 vs 免疫炎症代谢
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- **Business relevance**: OVB-organoids + 3Brain MEA = 眼-脑协同发育研究完整解决方案
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- **Business relevance**: OVB-organoids + 3Brain MEA = 眼-脑协同发育研究完整解决方案
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- **Tags**: OVB-organoids, cerebral-organoids, brain-development, retinal-organoid, FOXG1, VSX2
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- **Tags**: OVB-organoids, cerebral-organoids, brain-development, retinal-organoid, FOXG1, VSX2
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### 2026-08-11 - PMID 41909700
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- **Title**: Organoid-microglia system for modeling the immune microenvironment of the brain and retina
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- **Authors**: Yu J, Tang B, Gu Z, Wang G, Liu A
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- **Journal**: Frontiers in Immunology 2026, 17:1747589
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- **DOI**: 10.3389/fimmu.2026.1747589
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- **Wiki.js**: [ID 1709](http://10.10.10.254:3000/zh/organoid/yu-2026-organoid-microglia-front-immunol)
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- **NocoDB Id**: 715
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- **PDF**: [yu_2026_organoid_microglia.pdf](https://fb.biokingdom.top/f/4537d08bf4d14c6db0bc/?dl=1) + 4 张真图
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- **Key finding**: 类器官-小胶质细胞共培养 3 大策略 + 6 大应用 (AD/ASD/视网膜/药筛/CRISPR/OoC); 神经-免疫体外模型空白填补
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- **Business relevance**: 3Brain MEA + CelVivo ClinoStar + Femtobiomed CellShot + Cellink BIO X 4 大产品线全交叉
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- **Tags**: 类器官, 小胶质细胞, 神经免疫, 脑-视网膜, 共培养
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### 2026-08-11 - PMID 41686639
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- **Title**: High-throughput engineered tumor organoids reveal ROCK signaling as an immunotherapeutic target in triple-negative breast cancer
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- **Authors**: Zhou X, Zhu Y, Nicolas G, Wang Z, Lobie P, Ma S
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- **Journal**: Cell Reports 2026, 45:116987
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- **DOI**: 10.1016/j.celrep.2026.116987
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- **Wiki.js**: [ID 1710](http://10.10.10.254:3000/zh/organoid/zhou-2026-deo-rock-tnbc-cell-reports)
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- **NocoDB Id**: 3296
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- **PDF**: [zhou_2026_cell_reports_rock_tnbc.pdf](https://fb.biokingdom.top/f/bbe6f494811047c2bba0/?dl=1) + 6 张真图
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- **Key finding**: DEO 平台保留 TNBC 患者内源 TIL;ROCK 通路激动剂戊酸(PA)维持 TIL + 协同 anti-PD-1 解除 BLIS 亚型免疫抑制(联合治疗肿瘤抑制率 ~70%)
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- **Business relevance**: 4 大产品线全交叉 (CelVivo ClinoStar 培养/3Brain MEA 评估/Femtobiomed CellShot 基因编辑/Cellink BIO X 制造)
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- **Tags**: 肿瘤类器官, 三阴乳腺癌, ROCK信号, TIL, anti-PD-1, 戊酸, 马少华, BLIS亚型
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### 2026-08-11 - PMID 41536916
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- **Title**: Artificial Intelligence Virtual Organoids (AIVOs)
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- **Authors**: Bai L, Su J
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- **Journal**: Bioactive Materials 2026 (IF 18.2)
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- **DOI**: 10.1016/j.bioactmat.2025.12.030
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- **Type**: Review
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- **Wiki.js**: [ID 1711](http://10.10.10.254:3000/zh/organoid/bai-2026-aivos-bioactmat)
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- **NocoDB Id**: 502
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- **PDF**: [bai_2026_bioactmat_aivos.pdf](https://fb.biokingdom.top/f/59c6a647037346a28197/?dl=1) + 6 张真图
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- **Key finding**: AI Virtual Organoids (AIVOs) = 物理类器官 + AI 数字孪生; 数据-模型-交互三层架构; 6 大临床应用方向
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- **Business relevance**: 4 大产品线 (CelVivo ClinoStar / 3Brain MEA / Femtobiomed CellShot / Cellink BIO X) 全部可对接 AIVOs 平台 = 完整 湿+干 实验方案
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- **Tags**: 综述, 类器官, 人工智能, 虚拟器官, 数字孪生, 多组学, Bioactive-Materials-2026
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OpenWiki Bot
Robin