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chore: daily update 2026-08-13

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type: "Reference"
title: "Commitments"
description: "Active work tasks, follow-ups, approvals, and scheduled items extracted from sources (web-search, git-repo, literature flywheel-sync, etc.). Personal errands live in /personal-logistics.md instead."
tags: [commitments, work, follow-ups, distributors-2026-08-07-refresh, dong-huiqun-ji-nan-chengquan-link]
tags: [commitments, work, follow-ups, distributors-2026-08-07-refresh, dong-huiqun-ji-nan-chengquan-link, liang-2026-celvivo-clinostar-positioning]
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# Commitments
@@ -88,6 +88,13 @@ Concrete work tasks, follow-ups, approvals, and scheduled items extracted from G
- Status: open
- Notes: **Strongest CelVivo ClinoStar product relevance rating (5) in any of the 3 new flywheel-sync papers** — the vHLPO single 3D EB co-induction (mesoderm+endoderm) protocol depends on 3D EB self-organization in low-shear rotating culture, which is exactly what ClinoStar provides. vHLPO 7% ECs vs traditional HLPO 0% is a clinically-meaningful differentiator that no competing 2D / static culture can match. Sales ammunition: "your lung organoid model is missing 100% of vasculature — ClinoStar co-differentiation gives you 7% ECs vs 0%". Cross-vendor co-marketing: CelVivo ClinoStar (culture) + Cellink BIO X (decellularized lung scaffold) + 3Brain HD-MEA (functional readout on the neural mesenchyme). Robin should fold this into the CelVivo industrial-customers program (existing `CelVivo_中国工业客户开发研究报告` v1 + v2 in vault) and pitch to pediatric-hospital pharma R&D accounts (FOXF1 ACDMPV rare disease).
### liang-2026-celvivo-clinostar-positioning: fold Liang 2026 长程成熟 + 体外纤维化模型 story into CelVivo ClinoStar / ClinoReactor sales narrative
- Owner: me
- Source: git-repo-1 2026-08-12 (vault commit cluster `e542c977` → `8699a154` → `aacba7aa` → `297f106d`) — Liang Y, Ye Y, Xie H, Lui VCH, Chen Y, Tam PKH. (2026) *Scientific Reports* DOI 10.1038/s41598-026-42990-2, PMID 41857098; Wiki.js Id 1716, NocoDB Id 770; SeaFile PDF https://fb.biokingdom.top/f/9d53cfaaa88a45b49b72/?dl=1 + 7 真图 (Fig1-7); vault path `04-Literature/Deep-Reads/Liver/2026-08-12_Liang_2026_SciRep_liver_organoid_fibrosis_platform.md` (170 lines; 4-commit LDR cycle)
- Due: unscheduled
- Status: open
- Notes: **Parallel CelVivo ClinoStar rating 4 + ClinoReactor rating 4 to the existing `miao-2025-celvivo-clinostar-positioning`** but for **liver organoid (long-term maturation + fibrosis modeling)** rather than lung organoid (vascularization). Single tissue 3-轨道 (Hep-Orgs + Cho-Orgs + HSC) → DAPT (Notch 抑制) + Dexamethasone for **P1-P10 长程稳定成熟** (single DAPT only sustains P5; DAPT+Dex 协同才实现 P10) → TGFβ 5-7 day activation of qHSC → aHSC (Acta2/Col1a1 上调) → aHSC 共培养诱导 Hep-Orgs **EMT (Snail/Twist/Vimentin ↑; ALB/CK8 ↓; Lgr5/EpCAM ↓; Ki67 ↓)** = **体外肝纤维化模型**. Sales ammunition: "你的肝类器官只能短期培养? DAPT+Dex P1-P10 稳定成熟 + 单组织 3 轨道 + 14 天纤维化模型 — ClinoStar + ClinoReactor 一站搞定"; paired with "你的抗纤维化药筛需要 14+ 天 3D 多细胞模型 — ClinoReactor 6 通道一次测 6 药". Cross-vendor co-marketing: **CelVivo ClinoStar (P1-P10 旋转扩增) + CelVivo ClinoReactor (3 轨道分通道灌流 + TGFβ 时间程序精确切换) + 3Brain HD-MEA (肝-神经互作延伸, 胆碱能投射场景)**. Customer entry: (a) 药企临床前 — 抗纤维化药筛 14+ 天 3D 多细胞模型 (traditional 2D 或单细胞模型失真); (b) 临床肝活检中心 — 1-2 mg 组织 → 3 轨道 → 3 周内药敏测试 (患者来源 anti-fibrosis drug sensitivity); (c) 学术 PI — 2D 静态分化效率低 → 3D 旋转培养效率提升 2-3 倍. Robin should fold this into the CelVivo industrial-customers program (existing `CelVivo_中国工业客户开发研究报告` v1 + v2 in vault) alongside the Miao 2025 vHLPO entry — these two papers together give a liver + lung CelVivo ClinoStar sales narrative with no 3D-bioprinting vendor dependency. The paper's `related:` field already names `[[MOC-类器官与3D培养]]` (the 2026-08-10 first MOC) — confirms the MOC pattern is in active use on real deep-reads on the day of publication.
### robin-picked-papers-nocodb-table: capture the structural change — new NocoDB table for Robin-handpicked papers
- Owner: me
- Source: literature flywheel-sync 2026-08-08 — Liu 2026 is the **first entry** in the new NocoDB table `Robin_Picked_Papers` (table_id `mbjo0wb56qv1qly`), created 2026-08-08 per Robin instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage. The table is separate from the existing `Organoid_Literature` table.