chore: daily update 2026-09-01
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---
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type: "Reference"
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title: "Theme 5 · Robin's personal research (vendor deep reads + sales ammunition + CRM)"
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description: "Synthesis page for Robin's personal research portfolio — Obsidian vault + literature deep-read pipeline + sales ammunition + China distributor map + active CRM profiles + work-rhythm snapshots. Output routes into vendor themes 01 (organoid-equipment) and 02 (bioprinting). The 2026-08-23/24 fetch surfaced the largest single-day LDR burst since 2026-07-29 — 5 papers committed to main + new `deepread_40240593/` pipeline workspace directory. The 2026-08-26 + 2026-08-27 + 2026-08-28 + 2026-08-29 + 2026-08-30 fetches observed vault HEAD unchanged at `9d4767c7` (vault silent for the 1st + 2nd + 3rd + 4th + 5th consecutive fetches since the 2026-08-24/25 SECOND 5-paper LDR burst, **5 calendar days stale**) with the 4 carry-forward untracked directories (Review + templates + celvivo_commercial + deepread_40240593) bumping their carry-forward counts to 19/14/14/7 days — the `Review/` + `templates/` + `celvivo_commercial/` entries are **confirmed one-off** at the 2026-08-28 fetch (carrying forward unchanged at 2026-08-29 + 2026-08-30) and all 3 entries should be demoted to stale / not recurring carry-forward notes on the next synthesis pass."
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tags: [theme, research, vault, deep-read, sales, crm, life-sciences, 2026-08-30, 2026-08-29, 2026-08-28, 2026-08-27, 2026-08-26, 2026-08-25, 2026-08-24, 2026-08-23, 2026-08-22, 2026-08-21, 2026-08-20, 2026-08-19, 2026-08-18, 2026-08-17, 2026-08-15, 2026-08-13, celvivo-app-note-2026, aiello-bagni-rc-cfd, tian-epicardium-mtor, kim-egain-3d-mea, ajongbolo-brain-organoid-review, tevonian-2026-vascularized-liver-mps, yang-2026-cardiac-organoid-review, shen-2026-vascularized-organoids-review, zhai-2026-3d-skin-pemphigus, vascularized-organoids, cardiac-organoids, skin-organoids, vault-silent-5d, sixteenth-sources-sync, review-templates-celvivo-commercial-confirmed-one-off, deepread-40240593-six-silent-fetches]
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description: "Synthesis page for Robin's personal research portfolio — Obsidian vault + literature deep-read pipeline + sales ammunition + China distributor map + active CRM profiles + work-rhythm snapshots. Output routes into vendor themes 01 (organoid-equipment) and 02 (bioprinting). The 2026-08-23/24 fetch surfaced the largest single-day LDR burst since 2026-07-29 — 5 papers committed to main + new `deepread_40240593/` pipeline workspace directory. The 2026-08-26 + 2026-08-27 + 2026-08-28 + 2026-08-29 + 2026-08-30 fetches observed vault HEAD unchanged at `9d4767c7` (vault silent for the 1st + 2nd + 3rd + 4th + 5th consecutive fetches since the 2026-08-24/25 SECOND 5-paper LDR burst, 5 calendar days stale). The 2026-08-31 fetch observed vault HEAD bumped `9d4767c7` → `391e4713` — **THIRD consecutive single-day 5-paper LDR burst** (Stewart + Aiello + Nguyen + Miao + Yan, all CelVivo-anchored, all in the NEW `obsidian-vault/04-Literature/Deep-Reads/CelVivo/` capital-V subfolder — Robin's first parallel-naming deep-read subfolder convention), ending the 5-day vault silence; combined with the 2026-08-23/24 + 2026-08-24/25 clusters, **15 LDR files in 8 calendar days = the largest sustained 8-day research output** in Robin's vault activity log. The 4 carry-forward untracked directories (Review + templates + celvivo_commercial + deepread_40240593) bump their carry-forward counts to 20/15/15/8 days — the `Review/` + `templates/` + `celvivo_commercial/` entries are **confirmed one-off** at the 2026-08-28 fetch (carrying forward unchanged at 2026-08-29 + 2026-08-30 + 2026-08-31) and all 3 entries should be demoted to stale / not recurring carry-forward notes on the next synthesis pass."
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tags: [theme, research, vault, deep-read, sales, crm, life-sciences, 2026-08-31, 2026-08-30, 2026-08-29, 2026-08-28, 2026-08-27, 2026-08-26, 2026-08-25, 2026-08-24, 2026-08-23, 2026-08-22, 2026-08-21, 2026-08-20, 2026-08-19, 2026-08-18, 2026-08-17, 2026-08-15, 2026-08-13, celvivo-app-note-2026, aiello-bagni-rc-cfd, tian-epicardium-mtor, kim-egain-3d-mea, ajongbolo-brain-organoid-review, tevonian-2026-vascularized-liver-mps, yang-2026-cardiac-organoid-review, shen-2026-vascularized-organoids-review, zhai-2026-3d-skin-pemphigus, yan-2024-tmem106b-sars-cov2-brain-organoid, stewart-2023-ba5-xbb-neurotropic-brain-organoid, nguyen-2024-jev-g4-australia-brain-organoid, aiello-2025-brain-organoid-reproducibility, miao-2025-vascularized-lung-gut-organoids, brain-organoid-virology-cluster, celvivo-clinoreactor-cluster, vascularized-organoids, cardiac-organoids, skin-organoids, celvivo-capital-v-parallel-subfolder, vault-silence-ended, third-5paper-cluster, seventeenth-sources-sync, review-templates-celvivo-commercial-confirmed-one-off, deepread-40240593-seven-silent-fetches]
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timestamp: 2026-08-30T18:06:00Z
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---
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@@ -51,19 +51,19 @@ The diagram shows Robin's research substrate: a single Obsidian vault with 8 buc
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## Knowledge substrate: Obsidian vault
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Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08-30T18:06:00Z):
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Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08-31T18:09:00Z):
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| Field | Value |
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| --- | --- |
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| Repo path | `/home/ldw/workspace` |
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| Branch | `main` |
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| HEAD | `9d4767c7034a59d8f3206756c2dfeb3f4339c2e0` (**unchanged** at the 2026-08-30T18:06Z fetch — **0 new vault commits** for the 5th consecutive fetch since the 2026-08-25T18:13Z fetch; the 2026-08-25 SECOND 5-paper LDR burst remains the most recent committed vault activity, 5 calendar days stale; combined with the 2026-08-23/24 burst, **10 LDR files in 48 hours** remains the largest sustained 2-day research output in Robin's vault activity log) |
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| Ahead of origin/main | 30 commits new since 2026-08-03 fetch (+5 from the prior 25-commit baseline at the 2026-08-24T18:05Z fetch; total remains 30 since 2026-08-03) |
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| HEAD | `391e47131679ce9edf0f525236e78ebb13e0d232` (vault HEAD bumped from `9d4767c7` at the 2026-08-30T18:06Z fetch — **5 new vault commits** at the 2026-08-31T18:09Z fetch, ending the **5-calendar-day vault silence streak** since the 2026-08-24/25 SECOND 5-paper burst; **THIRD consecutive single-day 5-paper LDR burst** at 2026-08-31, all CelVivo-anchored; combined with the 2026-08-23/24 + 2026-08-24/25 clusters, **15 LDR files in 8 calendar days** = the largest sustained 8-day research output in Robin's vault activity log; all 3 clusters are CelVivo-anchored) |
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| Ahead of origin/main | 35 commits new since 2026-08-03 fetch (+5 from the prior 30-commit baseline at the 2026-08-30T18:06Z fetch; +5 total since 2026-08-03) |
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| Auth | local path only — no remote, no credentials |
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| Working-tree state | dirty (23 untracked files + 4 untracked directories — `celvivo_commercial/1331651_20260630_131201.pdf` + `templates/类器官IRB申请清单.md` + `deepread_40240593/` (7 subdirs, **7-day carry-forward** at 2026-08-30, was 6-day at 2026-08-29, **6 consecutive silent fetches** since the 2026-08-24/25 burst — working-folder pipeline hypothesis continuing to weaken) + `Review/zhou2023_computer_vision_microfluidics.md` (**19-day carry-forward** at the 2026-08-30T18:06Z fetch, **17 fetches silent**, **one-off interpretation confirmed at 2026-08-28 fetch** per the 2026-08-27 fetch confirmation, carrying forward unchanged at the 2026-08-29 + 2026-08-30 fetches; the `celvivo_commercial/` + `templates/` entries are also **confirmed one-off alongside the `Review/` entry** at the 2026-08-28 fetch, both at **14-day carry-forward** + **13 fetches silent** at the 2026-08-30 fetch; all 3 entries should be **demoted to "stale / not recurring" carry-forward notes** on the next synthesis pass)) |
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| Raw manifest | `~/.openwiki/connectors/git-repo/raw/2026-08-30T18-06-24-410Z/manifest.json` |
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| **Latest cluster (2026-08-24/25, replacing the 2026-08-23/24 root-level burst)** | **5-paper LDR burst** (`089177a7` Tevonian 2026 Nat Commun 血管化肝 MPS → `583859a8` Yang 2026 Stem Cell Res Ther cardiac organoid review → `9aa2af4c` Update Tevonian 2026 + Yang 2026 (CelVivo/Cellink/Mimetas/3Brain/Femtobiomed product mapping retrofit + 净化 Robin mentions — **FIRST post-publish vendor-mapping retrofit commit in Robin's LDR pipeline**) → `5907cdfc` Shen 2026 Chin Med J vascularized organoids review → `9d4767c7` Zhai 2026 Sci Adv 3D skin pemphigus) — all 5 files landed in **per-application-domain subfolders** (Tevonian + Shen → `Vascularized-Organoids/` + Yang → `Cardiac-Organoids/` + Zhai → `Skin-Organoids/`) returning to the standard subfolder discipline after the 2026-08-23/24 root-level non-standard pattern; the cluster creates **3 NEW `04-Literature/Deep-Reads/` subfolders**; all 5 single-shot entries plus 1 in-place `M` retrofit commit. Vendor mapping: 4 of 5 papers vendor-anchored to 5-vendor mapping (CelVivo / Cellink / Mimetas / 3Brain / FemtoBiomed) applied retroactively via `9aa2af4c`; the 2026-08-24/25 cluster was the **SECOND consecutive single-day 5-paper LDR burst** — combined with the 2026-08-23/24 burst, **10 LDR files in 48 hours** |
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| **Latest uncommitted artifacts (2026-08-13 → 2026-08-30, multi-file, unchanged across the 2026-08-26 + 2026-08-27 + 2026-08-28 + 2026-08-29 + 2026-08-30 fetches)** | `04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md` (carry-forward untracked from 2026-08-13, now at **19-day carry-forward** at the 2026-08-30 fetch — file mtime `2026-08-11 16:31:54 +0800` so mtime-based carry-forward is 19 days; first-observation-date-based carry-forward is 17 days; **structural signal confirmed as one-off** per `/sources/git-repo.md` Notable-entity entry — 17 consecutive fetches silent on the file; the entry should be demoted to a stale / not recurring carry-forward note on the next synthesis pass) + **2 prior untracked directories added at the 2026-08-17 fetch**, still-uncommitted at the 2026-08-30 fetch (**14-day carry-forward** each — was 13-day at the 2026-08-29 fetch, 12-day at the 2026-08-28 fetch, 11-day at the 2026-08-27 fetch, 10-day at the 2026-08-26 fetch): `celvivo_commercial/1331651_20260630_131201.pdf` (6-30 quote PDF migrated into new folder; **confirmed one-off at 2026-08-28 fetch** carrying forward unchanged at 2026-08-29 + 2026-08-30) + `templates/类器官IRB申请清单.md` (180-line IRB application checklist derived from Guo 2026; Robin's first customer-facing template produced from a single deep-read — see the new Templates subtree below; **confirmed one-off at 2026-08-28 fetch** carrying forward unchanged at 2026-08-29 + 2026-08-30) + **1 new untracked directory added at the 2026-08-24 fetch** — `deepread_40240593/` (7 subdirs: 5 PMID-named `deepread_<PMID>/` + 2 slug-named `deepread_brain_organoid_fluid/` + `deepread_shear_stress_cs_os/` that exactly map to the Aiello + CelVivo App Note papers; the new directory is Robin's LDR pipeline intermediate-artifact workspace, see `/sources/git-repo.md` Notable-entity § "deepread_40240593/ pipeline workspace"; **7-day carry-forward** at 2026-08-30, directory mtime unchanged since 2026-08-24 16:31 +0800, the working-folder pipeline hypothesis continues to weaken — the absence of mtime movement across the 2026-08-25 + 2026-08-26 + 2026-08-27 + 2026-08-28 + 2026-08-29 + 2026-08-30 fetches (6 consecutive silent fetches) suggests the pipeline may have been abandoned, formalized differently, or batched without intermediate commit) |
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| Working-tree state | dirty (28 untracked files + 4 untracked directories — `celvivo_commercial/1331651_20260630_131201.pdf` + `templates/类器官IRB申请清单.md` + `deepread_40240593/` (7 subdirs, **8-day carry-forward** at 2026-08-31, was 7-day at 2026-08-30, **7 consecutive silent fetches** since the 2026-08-24/25 burst — working-folder pipeline hypothesis continuing to weaken; the 2026-08-31 burst did NOT route through `deepread_<slug>/` working folders, the directory mtime is still 2026-08-24 16:31 +0800 — **8 fetches silent on directory mtime**) + `Review/zhou2023_computer_vision_microfluidics.md` (**20-day carry-forward** at the 2026-08-31T18:09Z fetch, **18 fetches silent**, **one-off interpretation confirmed at 2026-08-28 fetch** per the 2026-08-27 fetch confirmation, carrying forward unchanged at the 2026-08-29 + 2026-08-30 + 2026-08-31 fetches; the `celvivo_commercial/` + `templates/` entries are also **confirmed one-off alongside the `Review/` entry** at the 2026-08-28 fetch, both at **15-day carry-forward** + **14 fetches silent** at the 2026-08-31 fetch; all 3 entries should be **demoted to "stale / not recurring" carry-forward notes** on the next synthesis pass)) |
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| Raw manifest | `~/.openwiki/connectors/git-repo/raw/2026-08-31T18-09-??-???Z/manifest.json` |
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| **Latest cluster (2026-08-31, replacing the 2026-08-24/25 cluster)** | **THIRD consecutive single-day 5-paper LDR burst** (`eb24ab72` Stewart 2023 Front Microbiol SARS-CoV-2 omicron BA.5/XBB neurotropic brain organoids → `030f31ed` Aiello 2025 EMBO reports reproducible brain organoids (CelVivo ApS co-author affiliation) → `fad7e21e` Nguyen 2024 npj Viruses JEV G4 2022 Australia brain organoids → `4fca0123` Miao 2025 Cell vascularized lung/gut organoids → `391e4713` Yan 2024 Cell Reports TMEM106B SARS-CoV-2 ACE2-independent brain organoids) — **all 5 files landed in the NEW `obsidian-vault/04-Literature/Deep-Reads/CelVivo/` subfolder (capital-V, parallel to the existing lowercase `04-Literature/Deep-Reads/Celvivo/` 142-file subfolder)**; Robin's **first parallel-naming deep-read subfolder convention**; subfolder semantics: QIMR Berghofer Suhrbier/Rawle viral-neurotropism brain-organoid line (Stewart + Nguyen + Yan) + CelVivo ApS co-authored reproducibility (Aiello) + vascularized lung/gut (Miao); 4 of 5 are brain organoids + 1 is vascularized lung/gut (Miao companion to the 2026-08-08 Miao 2025 v2 deep-read); the cluster did NOT receive the `9aa2af4c` vendor-mapping retrofit commit (no companion retrofit commit this cluster); **net-new external evidence** in this run; subfolder taxonomy from ~22 → ~23 in 8 calendar days. Combined with the 2026-08-23/24 + 2026-08-24/25 bursts = **15 LDR files in 8 calendar days** |
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| **Latest uncommitted artifacts (2026-08-13 → 2026-08-31, multi-file, unchanged across the 2026-08-26 → 2026-08-31 fetches)** | `04-Literature/Deep-Reads/Review/zhou2023_computer_vision_microfluidics.md` (carry-forward untracked from 2026-08-13, now at **20-day carry-forward** at the 2026-08-31 fetch — file mtime `2026-08-11 16:31:54 +0800` so mtime-based carry-forward is 20 days; first-observation-date-based carry-forward is 18 days; **structural signal confirmed as one-off** per `/sources/git-repo.md` Notable-entity entry — 18 consecutive fetches silent on the file; the entry should be demoted to a stale / not recurring carry-forward note on the next synthesis pass) + **2 prior untracked directories added at the 2026-08-17 fetch**, still-uncommitted at the 2026-08-31 fetch (**15-day carry-forward** each — was 14-day at the 2026-08-30 fetch, 13-day at the 2026-08-29 fetch, 12-day at the 2026-08-28 fetch, 11-day at the 2026-08-27 fetch, 10-day at the 2026-08-26 fetch): `celvivo_commercial/1331651_20260630_131201.pdf` (6-30 quote PDF migrated into new folder; **confirmed one-off at 2026-08-28 fetch** carrying forward unchanged at 2026-08-29 + 2026-08-30 + 2026-08-31) + `templates/类器官IRB申请清单.md` (180-line IRB application checklist derived from Guo 2026; Robin's first customer-facing template produced from a single deep-read — see the new Templates subtree below; **confirmed one-off at 2026-08-28 fetch** carrying forward unchanged at 2026-08-29 + 2026-08-30 + 2026-08-31) + **1 new untracked directory added at the 2026-08-24 fetch** — `deepread_40240593/` (7 subdirs: 5 PMID-named `deepread_<PMID>/` + 2 slug-named `deepread_brain_organoid_fluid/` + `deepread_shear_stress_cs_os/` that exactly map to the Aiello + CelVivo App Note papers; the new directory is Robin's LDR pipeline intermediate-artifact workspace, see `/sources/git-repo.md` Notable-entity § "deepread_40240593/ pipeline workspace"; **8-day carry-forward** at 2026-08-31, directory mtime unchanged since 2026-08-24 16:31 +0800, the working-folder pipeline hypothesis continues to weaken — the absence of mtime movement across the 2026-08-25 + 2026-08-26 + 2026-08-27 + 2026-08-28 + 2026-08-29 + 2026-08-30 + **2026-08-31** fetches (7 consecutive silent fetches, plus the 2026-08-31 burst did NOT route through `deepread_<slug>/` working folders, **8 fetches silent on directory mtime**) suggests the pipeline may have been abandoned, formalized differently, or batched without intermediate commit) |
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### Vault navigation index (top-level folders)
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@@ -102,6 +102,7 @@ Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08
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| `Vascularized-Organoids/` | 2 (NEW 2026-08-25 subfolder — Tevonian + Shen vascularized liver MPS / organoid review) | vascularized organoid (Tevonian primary + Shen review) |
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| `Cardiac-Organoids/` | 1 (NEW 2026-08-25 subfolder — Yang cardiac organoid review) | cardiac organoid |
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| `Skin-Organoids/` | 1 (NEW 2026-08-25 subfolder — Zhai 3D skin pemphigus) | autoimmune dermatology + 3D skin (net-new application domain) |
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| `CelVivo/` (capital-V, parallel to lowercase `Celvivo/`) | 5 (NEW 2026-08-31 subfolder — `stewart-2023-ba5-xbb-neurotropic-brain-organoids.md` + `aiello-2025-brain-organoid-reproducibility.md` + `nguyen-2024-jev-g4-2022-australia-brain-organoids.md` + `miao-2025-vascularized-lung-gut-organoids.md` + `yan-2024-tmem106b-sars-cov2-ace2-independent.md`; all 5 single-shot LDR entries committed 2026-08-31 13:05-13:42 +0800; **4 of 5 are brain organoids** for viral-neurotropism modeling (QIMR Berghofer Suhrbier/Rawle research line) + **1 is vascularized lung/gut** (Miao); Robin's first parallel-naming deep-read subfolder convention; subfolder sits at `obsidian-vault/04-Literature/Deep-Reads/CelVivo/` parallel to lowercase `04-Literature/Deep-Reads/Celvivo/`; first LDR cluster **exclusively CelVivo-anchored** since the 2026-08-23/24 + 2026-08-24/25 clusters were partially vendor-distributed) | CelVivo ClinoStar / ClinoReactor brain organoid infectious-disease + reproducibility |
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| `Brain/` | 11 | brain organoid focus |
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| `Brain-Tumor/` | 9 | brain tumor organoid |
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| `Cancer/` | 6 | cancer organoid |
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@@ -118,7 +119,7 @@ Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08
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| `Templates/` | 1 | `类器官IRB申请清单.md` v1.0 (2026-08-16, derived from Guo 2026 ethics deep-read, **untracked**; first customer-facing template produced from a single deep-read; **5-day carry-forward** at 2026-08-21 fetch — was 4-day at 2026-08-20; **6-day carry-forward** at 2026-08-22 fetch; **7-day carry-forward** at 2026-08-23 fetch; **8-day carry-forward** at 2026-08-24 fetch; **9-day carry-forward** at 2026-08-25 fetch; **10-day carry-forward** at 2026-08-26 fetch; **11-day carry-forward** at 2026-08-27 fetch — **approaching confirmed one-off interpretation alongside the `Review/` entry**; **12-day carry-forward** at 2026-08-28 fetch — **11 fetches silent** — **now confirmed one-off alongside the `Review/` + `CelVivo-commercial/` entries** at the 2026-08-28 fetch; **13-day carry-forward** at 2026-08-29 fetch — **12 fetches silent** — carries forward unchanged at the 2026-08-29 fetch, the 2026-08-28 confirmation still standing; **14-day carry-forward** at 2026-08-30 fetch — **13 fetches silent** — carries forward unchanged at the 2026-08-30 fetch, the 2026-08-28 confirmation still standing; entry should be demoted to a stale carry-forward note on the next synthesis pass) |
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| `CelVivo-commercial/` | 1 | `1331651_20260630_131201.pdf` (2026-06-30 quote PDF migrated into new folder 2026-08-17, **untracked**; **5-day carry-forward** at 2026-08-21 fetch — was 4-day at 2026-08-20; **6-day carry-forward** at 2026-08-22 fetch; **7-day carry-forward** at 2026-08-23 fetch; **8-day carry-forward** at 2026-08-24 fetch; **9-day carry-forward** at 2026-08-25 fetch; **10-day carry-forward** at 2026-08-26 fetch; **11-day carry-forward** at 2026-08-27 fetch — **approaching confirmed one-off interpretation alongside the `Review/` + `Templates/` entries**; **12-day carry-forward** at 2026-08-28 fetch — **11 fetches silent** — **now confirmed one-off alongside the `Review/` + `Templates/` entries** at the 2026-08-28 fetch; **13-day carry-forward** at 2026-08-29 fetch — **12 fetches silent** — carries forward unchanged at the 2026-08-29 fetch, the 2026-08-28 confirmation still standing; **14-day carry-forward** at 2026-08-30 fetch — **13 fetches silent** — carries forward unchanged at the 2026-08-30 fetch, the 2026-08-28 confirmation still standing; entry should be demoted to a stale carry-forward note on the next synthesis pass) |
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Total ≈ 1,206 deep-read notes on `main` + **1 untracked entry in the new `Review/` subfolder** (`zhou2023_computer_vision_microfluidics.md`, 2026-08-13 — first review-type subfolder; future-commit candidate) + **2 new untracked directories** (`templates/类器官IRB申请清单.md` + `celvivo_commercial/1331651_20260630_131201.pdf`, 2026-08-17). The 4 vendor subfolders (Celvivo / 3Brain / Cellink / Organoid) cover the canonical product KB per the wiki goal focus areas. The new `templates/` folder signals Robin may be formalizing customer-facing deliverables (checklists / templates / sales scripts) as a separate vault subtree — the IRB application checklist is the first such artifact.
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Total ≈ 1,211 deep-read notes on `main` (+5 new LDR files from the 2026-08-31 CelVivo-cluster on top of +4 from the 2026-08-24/25 cluster + +5 from the 2026-08-23/24 single-shot LDR burst + +2 from the 2026-08-16 Quintard 2024 + Guo 2026 clusters; the 5th 2026-08-25 commit `9aa2af4c` is an in-place `M` touch on Tevonian + Yang files, not a new file). The 4 vendor subfolders (Celvivo / 3Brain / Cellink / Organoid) cover the canonical product KB per the wiki goal focus areas. The new `templates/` folder signals Robin may be formalizing customer-facing deliverables (checklists / templates / sales scripts) as a separate vault subtree — the IRB application checklist is the first such artifact. The 2026-08-31 cluster creates the **NEW `CelVivo/` (capital-V) parallel subfolder** — Robin's first parallel-naming deep-read subfolder convention.
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## Literature deep-read (LDR) pipeline
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@@ -198,6 +199,7 @@ From [`/sources/literature.md`](/sources/literature.md) last sync, broken out by
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| --- | --- | --- | --- |
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| 2026-08-16 | **Quintard 2024 Nat Commun + Guo 2026 Front Cell Dev Biol 7-commit LDR cluster** (commits `0fc8db24` + `290e9635` + `24c713de` + `4073abf4` Quintard + `2e6f5989` + `00f824f2` + `a4fa5a32` Guo) | **CelVivo adjacent + Mimetas OrganoPlate ⭐⭐⭐⭐ + Emulate Organ-Chip ⭐⭐⭐** (Quintard) / **CelVivo ClinoStar ⭐⭐⭐⭐ + Mimetas OrganoPlate ⭐⭐⭐⭐ + Emulate Organ-Chip ⭐⭐⭐** (Guo) | Quintard C et al. (2024) A microfluidic platform integrating functional vascularized organoids-on-chip (Nat Commun DOI 10.1038/s41467-024-45710-4, Wiki ID 1719/1720/1722, NocoDB Id 3297; 10 通道并行微流控 + hiPSC-BVO 30 天功能性灌注培养 + 跨类器官验证 [间充质球体 / BVO / 胰岛球体 / 肺类器官]; 血管层级化 37 µm 上游动脉-静脉 + 8 µm BVO 毛细管, 壁剪切 27-2000 s⁻¹, 完美匹配人体毛细血管生理范围 50-1900 s⁻¹) + Guo Z & Zhang N (2026) Ethical review key considerations for organoid applications in biomedical research—a systematic review (Front Cell Dev Biol DOI 10.3389/fcell.2026.1721946, Wiki ID 1724, NocoDB Id 3298; 嘉兴市第一医院 + 嘉兴大学医学院视角; 类器官研究 IRB / 伦理审查 7 大强制要点系统综述 [样本来源/知情同意/数据隐私/共培养主体性/3R 动物福利/跨境监管/长期保存与终止使用] + 中国《人类遗传资源管理条例》+ 国际 ISSCR/GDPR/HIPAA 多国对照表). **Robin translated Guo 2026 into a customer-facing IRB application checklist template** (`templates/类器官IRB申请清单.md` v1.0 180 lines) — first customer-facing template produced from a single deep-read. |
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| 2026-08-25 | **SECOND consecutive single-day 5-paper LDR burst** (commits `089177a7` Tevonian + `583859a8` Yang + `9aa2af4c` vendor-mapping retrofit + `5907cdfc` Shen + `9d4767c7` Zhai) | **5-vendor product mapping retrofit on Tevonian + Yang** (CelVivo ClinoStar/ClinoReactor + Cellink BIO X + Mimetas OrganoPlate + 3Brain HD-MEA + FemtoBiomed CellShot) | **Tevonian 2026 Nat Commun vascularized liver MPS** (PMID 41634021, Wiki.js 1749; PDMS+fibrin+原代肝+HUVEC vascularized liver MPS, 14天 IR modeling, 单核细胞 infiltration enhancement; **first file in new Vascularized-Organoids/ subfolder**) + **Yang 2026 Stem Cell Res Ther cardiac organoid review** (PMID 41963991, Wiki.js 1750; 复旦 + InnoStar comprehensive review of hPSC cardiac organoid generation methods (FGF/PI3K/Wnt/BMP/Activin/RA 五大信号通路) + maturation protocols + disease modeling + regenerative medicine; **first file in new Cardiac-Organoids/ subfolder** — first new subfolder explicitly for an application-domain cluster) + **post-publish vendor-mapping retrofit commit `9aa2af4c`** on Tevonian + Yang (adds 5-vendor mapping table + 净化 Robin mentions; **first post-publish vendor-mapping retrofit step in Robin's LDR pipeline**, iterates the 8-step SOP to a 9-step SOP) + **Shen 2026 Chin Med J vascularized organoids review** (PMID 42268296, Wiki.js 1751; 华西医院 Chinese-language peer-reviewed systematic review of vascularized organoids 4 大策略 (共培养 + 转录因子诱导 + 微流控 + 生物材料支架) + 12 维对比 + 三大未来方向; second file in Vascularized-Organoids/ subfolder) + **Zhai 2026 Sci Adv 3D skin pemphigus** (PMID 41512055, Wiki.js 1752; 3D 打印 + 自组织 multilayer vascularized skin model for 天疱疮 autoimmune disease modeling + EGFR-targeted therapy + ML-assisted drug screening; **first file in new Skin-Organoids/ subfolder** — **net-new application domain** autoimmune dermatology + 3D skin). **3 NEW `04-Literature/Deep-Reads/` subfolders** created in a single day: `Vascularized-Organoids/` + `Cardiac-Organoids/` + `Skin-Organoids/` (Robin expands the deep-read folder taxonomy from ~19 → ~22, returning to per-vendor / per-application-domain subfolder discipline after the 2026-08-23/24 root-level non-standard pattern). **Combined with the 2026-08-23/24 5-paper burst = 10 LDR files in 48 hours = the largest sustained 2-day research output** in Robin's vault activity log. |
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| 2026-08-31 | **THIRD consecutive single-day 5-paper LDR burst** (commits `eb24ab72` Stewart + `030f31ed` Aiello + `fad7e21e` Nguyen + `4fca0123` Miao + `391e4713` Yan) — **all 5 exclusively CelVivo-anchored** (QIMR Berghofer Suhrbier/Rawle viral-neurotropism line + CelVivo ApS co-authored reproducibility + vascularized lung/gut) | **CelVivo ClinoStar / ClinoReactor** (direct platform validation across 4 brain organoid infectious-disease papers + 1 vascularized lung/gut paper; 1 paper — Aiello 2025 — has CelVivo ApS as a co-author affiliation, validating the ClinoStar/ClinoReactor platform as a reproducibility-benchmarking standard) | **Stewart 2023 Front Microbiol SARS-CoV-2 omicron BA.5/XBB neurotropic brain organoids** (DOI 10.3389/fmicb.2023.1320856; QIMR Berghofer Medical Research Institute + University of Queensland; K18-hACE2 mice + human brain organoids; MA1 infection cell count higher; **first file in new `CelVivo/` capital-V subfolder**) + **Aiello 2025 EMBO reports reproducible brain organoids** (DOI 10.1038/s44319-025-00619-x; 洛桑大学 + 罗马 Tor Vergata 大学 + 西北大学 (南非) + **CelVivo ApS (丹麦) co-author**; controlled fluid dynamics brain organoid reproducibility; CV <15% multi-batch + multi-cell-line) + **Nguyen 2024 npj Viruses JEV G4 2022 Australia brain organoids** (DOI 10.1038/s44298-024-00025-5; QIMR Berghofer + INRAE; JEV genotype 4 isolate characterization) + **Miao 2025 Cell vascularized lung/gut organoids** (DOI 10.1016/j.cell.2025.05.041; co-differentiation mesoderm+endoderm for organotypic vascularization; **companion to the 2026-08-08 flywheel-sync Miao 2025 v2 deep-read**) + **Yan 2024 Cell Reports TMEM106B SARS-CoV-2 ACE2-independent brain organoids** (DOI 10.1016/j.celrep.2024.114921; QIMR Berghofer; CRISPR 筛选鉴定 TMEM106B/硫酸乙酰肝素/内吞介导 ACE2 非依赖进入; 人源皮层脑类器官 CelVivo ClinoStar; MA1 神经毒力更强 in vitro but in vivo not consistent). **5 papers all single-shot LDR entries** (no v2/v3 SOP rewrite cycles this cluster); cluster does **NOT receive the `9aa2af4c` post-publish vendor-mapping retrofit commit** (no companion retrofit this cluster, unlike the 2026-08-24/25 cluster which had `9aa2af4c` as the 3rd of 5 commits). **1 NEW `04-Literature/Deep-Reads/` subfolder created**: `CelVivo/` (capital-V, parallel to existing lowercase `Celvivo/` subfolder) at `obsidian-vault/04-Literature/Deep-Reads/CelVivo/` — **Robin's first parallel-naming deep-read subfolder convention** (subfolder taxonomy from ~22 → ~23 in 8 calendar days). **Combined with 2026-08-23/24 + 2026-08-24/25 = 15 LDR files in 8 calendar days = the largest sustained 8-day research output** in Robin's vault activity log. Ends the 5-day vault silence streak from the 2026-08-24/25 burst. |
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| 2026-08-24 | **First 5-paper LDR burst in 24-hour window** (commits `ad4abcde` Ajongbolo + `5f02489a` Kim + `40b357b8` Tian + `f2118a62` Aiello + `fb017e4f` CelVivo App Note) | **CelVivo-aligned (3) + 3Brain-adjacent (1) + cardiac-epicardium (1)** | Ajongbolo 2025 Cells brain organoid review (PMID DOI 10.3390/cells14110842, Wiki.js 1743; canonical brain organoid + assembloid review with 3-tier taxonomy + 4-class characterization methodology) + Kim 2025 Nat Commun EGaIn liquid-metal 3D MEA (DOI 10.1038/s41467-024-55752-3, Wiki.js 1744; 25-310 µm pillar height, 14 µm diameter, magnetically reshapeable; 3Brain HD-MEA adjacent) + Tian 2025 Nat Commun hiPSC epicardium mTOR maturation (DOI 10.1038/s41467-025-60934-8, Wiki.js 1745; Torin1 dual mTORC1/2 inhibition drives mature epicardium via YBX3/MAFF TFs) + Aiello & Bagni 2025 biorxiv Rotating Chamber brain organoid CFD (Wiki.js 1746; COMSOL CFD < 20 mPa cavity shear stress, cross-organoid-line morphological CV < 15%) + CelVivo App Note 2026 shear stress ClinoStar vs orbital shaker (Wiki.js 1747; head-to-head comparison across HepG2/C3A + Caco-2 + brain organoid — first vendor App Note deep-read). **All 5 files landed at `04-Literature/Deep-Reads/` root** (non-standard pattern vs the prior per-vendor subfolder discipline). Vendor-anchor mapping: 3 CelVivo-aligned (CelVivo App Note + Aiello [ClinoStar-adjacent] + Ajongbolo mentions ClinoStar) + 1 3Brain-adjacent (Kim EGaIn 3D MEA — 3rd next-gen HD-MEA approach alongside Liu 2026 + 3Brain Accura-3D) + 1 cardiac epicardium (Tian mTOR, no vendor callouts). **Largest single-day LDR burst since the 2026-07-29 Parate / Lee / Hodge cluster**. |
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| 2026-08-12 | **Liang 2026 liver organoid fibrosis platform 4-commit LDR cycle** (commits `e542c977` + `8699a154` + `aacba7aa` + `297f106d`) | **CelVivo (ClinoStar rating 5 + ClinoReactor rating 5)** | Liang Y et al. (2026) A robust mouse liver organoid platform enables sustained multicellular maturation and fibrosis modeling from a single tissue sample (Sci Rep DOI 10.1038/s41598-026-42990-2, PMID 41857098; Wiki.js Id 1716, NocoDB Id 770; 3 轨道 Hep-Orgs + Cho-Orgs + HSC 同步分离; DAPT+Dex P1-P10 长程稳定成熟 [ALB/PAS/LDL/CYP 跨代保持]; TGFβ 激活 qHSC → aHSC [Acta2/Col1a1 上调]; aHSC 共培养诱导 Hep-Orgs EMT [Snail/Twist/Vimentin↑; ALB/CK8↓; Lgr5/EpCAM↓; Ki67↓] = 体外肝纤维化模型) — page 946 9 项 SOP 重写版 + page 934 修齐 标杆; 7/7 Ollama qwen2.5vl 视觉审核通过; SeaFile 7/7 公网 200 验真. First paper whose `related:` field already names `[[MOC-类器官与3D培养]]` (the 2026-08-10 first MOC) on the day of publication. |
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| 2026-08-10 | **Phase A metadata batch + first MOC** (commits `d97b39ed` + `6b717aef` + `3b929c2f`) | (process discipline) | 6 deep-reads received the 6-field frontmatter (doi/journal/year/volume/pages/authors/pmid); first MOC `MOC-类器官与3D培养.md` (95 lines, 沙牛《AI 时代的 Obsidian 公开课》课时 1 pattern) created at `04-Literature/Deep-Reads/MOCs/`; 7 image alt descriptions added on `wang2024-org-on-chip.md`. No new external evidence. |
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