chore: daily update 2026-08-28

sources/literature.md

@@ -2,8 +2,8 @@
 type: "Reference"
 title: "Literature Deep-Reads — cross-agent deep-read index"
 description: "Cross-agent index of Robin's literature deep-reads across the 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed) and adjacent application domains (organoid IRB / ethics, vascularized organoids, microfluidic / organ-on-chip). Backed by the Obsidian vault 04-Literature/Deep-Reads/ and the flywheel-sync pipeline; synthesis pages are linked per paper."
-tags: [literature, deep-read, flywheel, celvivo, 3brain, cellink, femtobiomed, tevonian-2026-vascularized-liver-mps, yang-2026-cardiac-organoid-review, shen-2026-vascularized-organoids-review, zhai-2026-3d-skin-pemphigus, 2026-08-25]
-timestamp: 2026-08-25T18:13:00Z
+tags: [literature, deep-read, flywheel, celvivo, 3brain, cellink, femtobiomed, tevonian-2026-vascularized-liver-mps, yang-2026-cardiac-organoid-review, shen-2026-vascularized-organoids-review, zhai-2026-3d-skin-pemphigus, pasca-2025-nature-assembloid, microgravity-reproductive-review-2026, 2026-08-27, 2026-08-25, 2026-08-24, 2026-08-23, vascularized-organoids, cardiac-organoids, skin-organoids, second-5paper-burst]
+timestamp: 2026-08-27T18:25:00Z
 ---
 
 # Literature Deep-Reads — cross-agent deep-read index
@@ -336,3 +336,31 @@ The `Robin_Picked_Papers` table is **new as of today** — created per Robin's 2
 - **Wiki ID**: 1752
 - **关键发现**: 3D 打印 + 自组织多层血管化皮肤模型, 建模天疱疮自身免疫 + EGFR 靶向治疗 + ML 辅助药筛
 - **Robin 业务对接**: 皮肤自身免疫病药筛 + 3D 打印客户 + 精准医疗应用
+
+## https://fb.biokingdom.top/api/v4/file/content/m99qHL/0/pasca...
+
+- **Title**: Human assembloid model of the ascending neural sensory pathway
+- **Authors**: Ji-il Kim, Kent Imaizumi, Ovidiu Jurjut, Kevin W. Kelley, Dong Wang, Mayuri V. Thete, Zuzana Hudacova, Neal D. Amin, Rebecca J. Levy, Gregory Scherrer, Sergiu P. Pasca
+- **Venue**: Nature (5 June 2025)
+- **DOI**: 10.1038/s41586-025-08808-3
+- **PMID**: 40205039 | **PMC**: PMC12137141
+- **Wiki.js**: https://wiki.biokingdom.top/literature/pasca-2025-nature-hasa-assembloid (ID 1758)
+- **NocoDB Brain 表**: Id=104
+- **PDF**: https://fb.biokingdom.top/api/v4/file/content/m99qHL/0/pasca-2025-assembloid-20260827.pdf
+- **Citations**: 99 (Nature 主刊 4 个月)
+- **Business match**: CelVivo ClinoStar ⭐⭐⭐⭐⭐ + 3Brain BioCAM X ⭐⭐⭐⭐⭐ + Mimetas OrganoPlate ⭐⭐⭐⭐ + Cellink BIO X ⭐⭐⭐⭐ + Femtobiomed CellShot ⭐⭐⭐
+- **Method**: First 4-part assembloid (hSeO/hdSpO/hDiO/hCO) from hiPS cells, scRNA-seq (54K cells), rabies tracing, calcium imaging, MEA extracellular recording. SCN9A/NaV1.7 KO reproduces CIP (Congenital Insensitivity to Pain).
+- **Date added**: 2026-08-27
+
+## iScience 2026 - Microgravity Reproductive Review
+
+- **Title**: A systematic review of microgravity on reproductive systems: Implications for space biology and human health
+- **Authors**: C.-F.L., C.-Y.C., P.-T.L., Y.-C.H. (corresponding)
+- **Venue**: iScience (13 Jan 2026)
+- **DOI**: 10.1016/j.isci.2026.114663
+- **PMID**: 41675042 | **PMC**: PMC12886544
+- **Wiki.js**: https://wiki.biokingdom.top/literature/microgravity-reproductive-review-2026 (ID 1759)
+- **NocoDB Brain 表**: Id=105
+- **PDF Status**: 5 路径 + S2 + Europe PMC 镜像全失败 (Robin 8-26 撞坑诚实停手);RAGFlow 解析文本 82546B 可下
+- **Method**: First cross-paradigm review (spaceflight + SMG + animal + human). 7 mechanisms (oxidative stress / DNA damage / cell signaling / cytoskeleton / mitochondria / EV / epigenetics). Countermeasures: AG / antioxidants / cryopreservation / RNAi.
+- **Date added**: 2026-08-27