From 523ee7f540a80802fed5b74afe7e9b00f02658f1 Mon Sep 17 00:00:00 2001
From: Robin <20864114@qq.com>
Date: Tue, 11 Aug 2026 13:40:38 +0800
Subject: [PATCH] lit: PMID 41686639 Cell Reports TNBC DEO + ROCK (Wiki.js
 1710)

---
 sources/literature.md | 13 +++++++++++++
 1 file changed, 13 insertions(+)

diff --git a/sources/literature.md b/sources/literature.md
index 6738086..7a74efd 100644
--- a/sources/literature.md
+++ b/sources/literature.md
@@ -197,3 +197,16 @@ The `Robin_Picked_Papers` table is **new as of today** — created per Robin's 2
 - **Key finding**: 类器官-小胶质细胞共培养 3 大策略 + 6 大应用 (AD/ASD/视网膜/药筛/CRISPR/OoC); 神经-免疫体外模型空白填补
 - **Business relevance**: 3Brain MEA + CelVivo ClinoStar + Femtobiomed CellShot + Cellink BIO X 4 大产品线全交叉
 - **Tags**: 类器官, 小胶质细胞, 神经免疫, 脑-视网膜, 共培养
+
+### 2026-08-11 - PMID 41686639
+
+- **Title**: High-throughput engineered tumor organoids reveal ROCK signaling as an immunotherapeutic target in triple-negative breast cancer
+- **Authors**: Zhou X, Zhu Y, Nicolas G, Wang Z, Lobie P, Ma S
+- **Journal**: Cell Reports 2026, 45:116987
+- **DOI**: 10.1016/j.celrep.2026.116987
+- **Wiki.js**: [ID 1710](http://10.10.10.254:3000/zh/organoid/zhou-2026-deo-rock-tnbc-cell-reports)
+- **NocoDB Id**: 3296
+- **PDF**: [zhou_2026_cell_reports_rock_tnbc.pdf](https://fb.biokingdom.top/f/bbe6f494811047c2bba0/?dl=1) + 6 张真图
+- **Key finding**: DEO 平台保留 TNBC 患者内源 TIL;ROCK 通路激动剂戊酸(PA)维持 TIL + 协同 anti-PD-1 解除 BLIS 亚型免疫抑制(联合治疗肿瘤抑制率 ~70%)
+- **Business relevance**: 4 大产品线全交叉 (CelVivo ClinoStar 培养/3Brain MEA 评估/Femtobiomed CellShot 基因编辑/Cellink BIO X 制造)
+- **Tags**: 肿瘤类器官, 三阴乳腺癌, ROCK信号, TIL, anti-PD-1, 戊酸, 马少华, BLIS亚型