chore: daily update 2026-08-09
This commit is contained in:
OpenWiki Bot
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{
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"updatedAt": "2026-08-07T12:33:48.652Z",
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"updatedAt": "2026-08-08T18:33:44.986Z",
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"command": "update",
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"model": "MiniMax-M3",
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"status": "complete",
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---
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type: "Reference"
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title: "Commitments"
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openwiki_generated: true
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description: "Active work tasks, follow-ups, approvals, and scheduled items extracted from sources (web-search, git-repo, literature flywheel-sync, etc.). Personal errands live in /personal-logistics.md instead."
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tags: [commitments, work, follow-ups, distributors-2026-08-07-refresh, dong-huiqun-ji-nan-chengquan-link]
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---
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# Commitments
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@@ -73,6 +74,41 @@ Concrete work tasks, follow-ups, approvals, and scheduled items extracted from G
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- Status: open
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- Notes: Personal-infra work item (workflow-tooling priority LOW), not vendor-anchored — logged here because it is source-anchored to Robin's actual vault work per the brief's commitments.md rule ("only real Robin commitments"). Plan: mATX + i5-12400 + DDR4-2666 32G + 板载 Realtek 1Gb + Intel PRO/1000 GT (¥2,985.82, 10/11 parts on hand). Two 网卡 VLAN: 192.168.31.100 → 主力机 Win 11 SSH, 10.10.10.254 → 主力 NAS RAGFlow. Post-assembly steps: Ubuntu Server 22.04 LTS install, partition `/` (GM7 512G) + `/data` (mSATA 512G), Docker, dual-NIC 静态 IP, 主力机 SSH key 免密, NAS RAGFlow API 接入, 安装 Hermes Agent, 24h 跑功耗 soak test. The host has no vendor-product overlap; not promoted to `/themes.md` row because that index is reserved for recurring workflow signals.
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### liu-2026-hd-mea-roadmap-implication: verify with 3Brain whether the Liu 2026 shape-conformal framework is on their product roadmap
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- Owner: me
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- Source: literature flywheel-sync 2026-08-08 — Liu N et al. (2026) Nature Biomedical Engineering, DOI 10.1038/s41551-026-01620-y, Wiki.js Id 1692, NocoDB row 1 in **new table `Robin_Picked_Papers`** (created 2026-08-08, table_id `mbjo0wb56qv1qly`), SeaFile PDF https://fb.biokingdom.top/f/6da50240729e41bdb369/?dl=1. Deep-read synthesis at [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md)
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- Due: unscheduled
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- Status: open
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- Notes: **Highest product-relevance cluster of today's flywheel-sync**: HD-MEA rating 5 (3000-8000 channels vs current 3Brain Accura-3D 4096; >90% surface coverage vs 5-15% bottom-only), 3D bioprinting microlattice rating 5 (Cellink BIONOVA X / Lumen X cannot directly print at this resolution today but the field direction is clear), patient-derived organoid drug screening rating 5 (first long-term high-throughput electrophysiology drug screening platform — weeks-long stable recording + epilepsy + AD disease modeling). Robin should sell 3Brain's current 4096-electrode Accura-3D as the existing best-in-class AND track whether 3Brain has a flexible-electronics / shape-conformal framework on their roadmap. Companion question on `/open-questions.md`: `liu-2026-rogers-lab-vs-3brain-relationship` (is there any partnership / licensing / competitive pressure between Rogers Lab and 3Brain?). Companion commitment to verify with Cellink: `liu-2026-cellink-microlattice-positioning` (whether BIONOVA X or Lumen X can fabricate flexible-electronics-compatible microlattices).
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### miao-2025-celvivo-clinostar-positioning: fold Miao 2025 vHLPO co-differentiation story into CelVivo ClinoStar sales narrative
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- Owner: me
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- Source: literature flywheel-sync 2026-08-08 — Miao Y et al. (2025) Cell v2, DOI 10.1016/j.cell.2025.05.041, PMID 40592324, Wiki.js Id 1681, NocoDB row 93, SeaFile PDF https://fb.biokingdom.top/f/24704d54a95941449e2e/?dl=1. Deep-read synthesis at [`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`](/sources/literature-miao-2025-cell-vascularization-v2-deepread.md)
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- Due: unscheduled
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- Status: open
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- Notes: **Strongest CelVivo ClinoStar product relevance rating (5) in any of the 3 new flywheel-sync papers** — the vHLPO single 3D EB co-induction (mesoderm+endoderm) protocol depends on 3D EB self-organization in low-shear rotating culture, which is exactly what ClinoStar provides. vHLPO 7% ECs vs traditional HLPO 0% is a clinically-meaningful differentiator that no competing 2D / static culture can match. Sales ammunition: "your lung organoid model is missing 100% of vasculature — ClinoStar co-differentiation gives you 7% ECs vs 0%". Cross-vendor co-marketing: CelVivo ClinoStar (culture) + Cellink BIO X (decellularized lung scaffold) + 3Brain HD-MEA (functional readout on the neural mesenchyme). Robin should fold this into the CelVivo industrial-customers program (existing `CelVivo_中国工业客户开发研究报告` v1 + v2 in vault) and pitch to pediatric-hospital pharma R&D accounts (FOXF1 ACDMPV rare disease).
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### robin-picked-papers-nocodb-table: capture the structural change — new NocoDB table for Robin-handpicked papers
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- Owner: me
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- Source: literature flywheel-sync 2026-08-08 — Liu 2026 is the **first entry** in the new NocoDB table `Robin_Picked_Papers` (table_id `mbjo0wb56qv1qly`), created 2026-08-08 per Robin instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage. The table is separate from the existing `Organoid_Literature` table.
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- Due: unscheduled
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- Status: open
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- Notes: The new table has 9 fields: Title, DOI, Journal, Year, Authors, Source, wiki_url, pdf_url, deep_read_summary. Future handpicked papers should land in this table rather than in `Organoid_Literature` (which is PubMed-triage-driven). Verify with Robin: (a) what is the workflow for capturing a handpicked paper — manual PDF drop to `/home/ldw/.hermes/cache/documents/` and then trigger the LDR pipeline; (b) should the LDR pipeline auto-route by signal (PubMed triage vs handpicked), or does Robin always provide the routing signal.
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### dong-huiqun-ji-nan-chengquan-link: confirm whether 董慧群 is a 济南成全生物科技 技术同事, and route 卸慧群档案 accordingly
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- Owner: me
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- Source: git-repo 2026-08-08 — `02-Clients/Agents/_known_associations.md` (commit `4b237a82`, Hermes Agent 2026-08-07 hook 4) maps 济南成全生物科技有限公司 (曹沛起) as the **only CelVivo ClinoStar-listed agent** in the 259-dealer China map (华北 + 山东 跨区重复登记). `02-Clients/Agents/董慧群.md` (2026-07-28 commit `21491578`) lists 董慧群 as CelVivo 产品技术同事 with `agency: 待补`.
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- Due: unscheduled
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- Status: open
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- Notes: The 2026-08-07 hook 4 partial-resolution gave a likely candidate (济南成全生物科技 曹沛起 company) but the precise link to 董慧群 (and whether she is 济南成全的技术同事, or another dealer) is still unverified. Action: Robin to verify with 董慧群 directly via WeChat / 微信 (current open-question [`/open-questions.md`](/open-questions.md) `agent-dong-huiqun-celvivo`). Once confirmed: update `02-Clients/Agents/董慧群.md` frontmatter `agency` field, and update [`/sources/agents.md`](/sources/agents.md) "代理商品牌" column from "待补" to "济南成全生物科技 (曹沛起)". Until this is done, 董慧群's role in the 济南成全 book of business is unconfirmed.
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### distributors-2026-08-07-refresh: 落地 2026-08-07 全国经销商地图到 wiki + 跨工具
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- Owner: me
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- Source: git-repo 2026-08-08 — Obsidian vault `02-Clients/Agents/全国经销商地图-2026-0807.md` + 7 区域分文件 (8-07 baseline, 259 dealers across 7 regions, net change -2 from 2026-07-24 baseline). Vault raw survives 2026-08-08 fetch as untracked files (commit `4b237a82` Lin Yongli "4 个经销商管理 Hook 升级").
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- Due: unscheduled
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- Status: open
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- Notes: 8-07 baseline differs from 7-24 baseline in: (a) total 261 → 259 (华北 74 → 72); (b) 济南成全生物科技有限公司 (曹沛起) cross-region registration (华北 + 山东); (c) new `_known_associations.md` index maps CelVivo → 济南成全 / FemtoBiomed → 9X Bio → TriArm / 3Brain + Cellink → 0. Cross-reference: [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) has been updated to the 8-07 baseline + new associations table; [`/sources/agents.md`](/sources/agents.md) still needs the 董慧群 → 济南成全 link; [`/commitments.md`](/commitments.md) has follow-up for 成都百乐 vs 成都立德赛 decision (open-question `chengdu-baile-vs-lidesai-for-ou-xianhong`). End-customer coverage for 3Brain / Cellink / FemtoBiomed still 0 in the 259 baseline — see open-question `distributors-3brain-cellink-zero-coverage`.
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<!--
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Structure for new entries:
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@@ -4,13 +4,13 @@ okf_version: "0.1"
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# Files
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- [Commitments](commitments.md)
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- [Commitments](commitments.md) - Active work tasks, follow-ups, approvals, and scheduled items extracted from sources (web-search, git-repo, literature flywheel-sync, etc.). Personal errands live in /personal-logistics.md instead.
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- [2026-07-16 工具链打通战报](memory-2026-07-16-tools-final.md)
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- [Open Questions](open-questions.md)
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- [Personal Logistics](personal-logistics.md)
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- [Open Questions](open-questions.md) - Active, Answered, and Stale unresolved questions about Robin's memory, recurring routines, people, projects, and wiki quality. Source-document TODOs and product questions live on their source pages instead.
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- [Personal Logistics](personal-logistics.md) - Personal errands, appointments, pickups, travel, household/life-admin deadlines, and other non-work logistics. Work commitments live in /commitments.md.
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- [Robin's Local Knowledge Base](quickstart.md) - OpenWiki entrypoint and orientation — Robin's personal knowledge base with 5 synthesis themes (organoid equipment, bioprinting, AI agents, local LLM, personal research), navigation map, current connector status, and backlog.
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- [OpenWiki 现状 + 操作手册 (2026-07-27)](README-ACTIVATION.md)
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- [Themes](themes.md)
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- [Themes](themes.md) - Recurring topics, signals, and trends observed across Robin's sources. Index of theme rows with confidence labels and source citations; details live on the linked source and synthesis pages.
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# Directories
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---
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type: "Reference"
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title: "Open Questions"
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openwiki_generated: true
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description: "Active, Answered, and Stale unresolved questions about Robin's memory, recurring routines, people, projects, and wiki quality. Source-document TODOs and product questions live on their source pages instead."
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tags: [open-questions, unresolved, agent-dong-huiqun-celvivo, chengdu-baile-vs-lidesai-for-ou-xianhong, distributors-3brain-cellink-zero-coverage]
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---
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# Open Questions
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@@ -13,8 +14,32 @@ Unresolved questions about Robin's memory, recurring routines, people, projects,
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### agent-dong-huiqun-celvivo: which distributor does 董慧群 belong to, and what region / customers / contact info does she cover?
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- Owner: me (Robin)
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- Seen: 2026-07-28
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- Evidence: `02-Clients/Agents/董慧群.md` in the Obsidian vault (frontmatter `type: agent`, role: 代理商技术同事, products: CelVivo ClinoStar / ClinoReactor, status: active, last-contact: 2026-07-28). Manifest entry: `~/.openwiki/connectors/git-repo/raw/2026-07-28T18-07-57-114Z/manifest.json` commit `21491578`. Vault nav: `/sources/git-repo.md` → Notable entities.
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- Notes: profile is mostly 待补 (agency company name, region, phone, WeChat, served end-customers, opportunities). Robin was told about 董慧群 via WeChat DM on 2026-07-28 — her role is to help push CelVivo products at the technical / demo / selection stage. Until the agency and region are filled in, future agents cannot reason about which CelVivo deals 董慧群 might support or which Chinese pharma R&D / CDMO accounts overlap with her territory. This is the kind of "ambiguous people/org relationship" gap the brief calls out — fills in as Robin contacts her.
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- Evidence: `02-Clients/Agents/董慧群.md` in the Obsidian vault (frontmatter `type: agent`, role: 代理商技术同事, products: CelVivo ClinoStar / ClinoReactor, status: active, last-contact: 2026-07-28). Manifest entry: `~/.openwiki/connectors/git-repo/raw/2026-07-28T18-07-57-114Z/manifest.json` commit `21491578`. 2026-08-07 partial resolution: `02-Clients/Agents/_known_associations.md` (commit `4b237a82`, Hermes Agent hook 4) identifies **济南成全生物科技有限公司 (曹沛起)** as the only ClinoStar-listed agent in the 259-dealer China map — 华北 + 山东 跨区重复登记. Cross-reference at [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) § "8-07 新增：_known_associations.md 索引".
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- Notes: profile is mostly 待补 (agency company name, region, phone, WeChat, served end-customers, opportunities). Robin was told about 董慧群 via WeChat DM on 2026-07-28 — her role is to help push CelVivo products at the technical / demo / selection stage. The 2026-08-07 `123hook_4` partial-resolution gave a likely candidate (济南成全生物科技有限公司 — same contact 曹沛起 in both 华北表 + 山东表) but the precise link to 董慧群 (and whether she is 济南成全的技术同事, or another dealer) is still unverified. Until confirmed, future agents cannot reason about which CelVivo deals 董慧群 might support or which Chinese pharma R&D / CDMO accounts overlap with her territorial reach. The narrower, still-open question is: **is 董慧群 济南成全生物科技 (曹沛起) 的技术同事, or another CelVivo-aligned agent?**
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### liu-2026-rogers-lab-vs-3brain-relationship: is there any partnership / licensing / competitive pressure between Rogers Lab (Liu 2026) and 3Brain?
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- Owner: me (Robin)
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- Seen: 2026-08-08
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- Evidence: literature flywheel-sync 2026-08-08 — Liu N et al. (2026) Nature Biomedical Engineering, DOI 10.1038/s41551-026-01620-y, Wiki.js Id 1692, SeaFile PDF https://fb.biokingdom.top/f/6da50240729e41bdb369/?dl=1. Deep-read at [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md). Commitment at [`/commitments.md`](/commitments.md) `liu-2026-hd-mea-roadmap-implication`.
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- Notes: Liu 2026 establishes a next-gen shape-conformal porous framework for full-coverage (>90% surface) neural organoid electrophysiology at 3000-8000 channels per organoid (10-50× current 3Brain Accura-3D). Rogers Lab (Northwestern) is a major flexible-electronics / bioelectronics group. Three plausible relationships with 3Brain: (a) **partnership** — Rogers Lab licenses the flexible-electronics framework to 3Brain for productization; (b) **competitive pressure** — Rogers Lab or a spinout company commercializes the framework as a competing HD-MEA product; (c) **academic-only** — Rogers Lab has no commercial intent and 3Brain continues to be the best-in-class commercial HD-MEA. Until this is clarified, Robin cannot advise 3Brain customers on whether to wait for next-gen HD-MEA hardware or buy current Accura-3D now. Future agents reading Liu 2026 should treat the "next-gen direction" framing with caution until the 3Brain roadmap is verified.
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### chengdu-baile-vs-lidesai-for-ou-xianhong: which 成都 dealer should Robin approach first for 西南医科大学心研所 (殴贤红) CelVivo / 3Brain cross-sell?
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- Owner: me (Robin)
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- Seen: 2026-08-07
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- Evidence: `02-Clients/Agents/_known_associations.md` (Obsidian vault, 2026-08-07 commit `4b237a82`) — 候选代理 A: **成都百乐 (杨军)** — 覆盖川渝黔藏 · 1亿/钻石 · 主营 Bio-Rad/Sartorius/Oxford Nanopore/Cytek/Leica; 候选代理 B: **成都立德赛** — 覆盖川渝云贵陕. End-customer: 西南医科大学心血管研究所 (殴贤红, 四川泸州). Cue: Hermes hook 4 recommended "先联系 成都百乐 (钻石级 1亿, 主营匹配度更高)". Cross-reference: [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) § "8-07 新增：_known_associations.md 索引".
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- Notes: Robin needs to pick the first 成都 dealer to approach for the 殴贤红 CelVivo / 3Brain cross-sell. Two candidates identified in the 2026-08-07 `_known_associations.md` sweep: 成都百乐 (1亿/钻石级, 川渝黔藏 + 主营 Bio-Rad/Sartorius/Oxford Nanopore/Cytek/Leica — overlap with FemtoBiomed / 3Brain product line) vs 成都立德赛 (覆盖川渝云贵陕, 主营待查). Hermes hook 4 default recommendation is 成都百乐, but Robin's existing relationship depth with either dealer is unknown. Until Robin makes the call, the cross-sell cannot be initiated.
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### distributors-3brain-cellink-zero-coverage: 259 dealer list shows 0 三Brain / 0 Cellink / 0 FemtoBiomed direct agents — is the channel gap real, or is the 8-04 xlsx missing these brands?
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- Owner: me (Robin)
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- Seen: 2026-08-07
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- Evidence: `02-Clients/Agents/_known_associations.md` (Obsidian vault, 2026-08-07 commit `4b237a82`) — product-line hit summary shows only CelVivo (济南成全) directly; 3Brain / Cellink / FemtoBiomed all 0. FemtoBiomed CellShot is documented as a 9X Bio (汇佰生物) direct intermediate, not in the 259 dealer list. Cross-reference: [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) § "8-07 新增：_known_associations.md 索引".
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- Notes: The 2026-08-07 xlsx-baseline scan found zero dealers in the 259-row list that explicitly carry 3Brain HD-MEA or Cellink BIO X. For 3Brain HD-MEA, where Robin has 11+ end-customer dossiers (神经所 / 北京大学 / 北京天坛 / 浙大一附院 / 中科院昆明 / 西南医大 / 贵州医大 / 云南中医药 / 天津创新中药), this is a striking gap — either (a) the 8-04 xlsx is missing the 3Brain agents, or (b) no Chinese distributor has picked up 3Brain and Robin needs to either find/appoint one or sell direct. Until Robin clarifies, the 3Brain-side commercial strategy (channel vs direct) for the +11 known Chinese end-customers remains unresolved.
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### sharma-2026-retinal-organoid-mea-cross-sell: does the 60-channel MCS MEA route transfer cleanly to 3Brain HD-MEA for vascularized retinal organoid RGC recording?
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- Owner: me (Robin)
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- Seen: 2026-08-08
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- Evidence: literature flywheel-sync 2026-08-08 — Sharma K et al. (2026) Cell Stem Cell 33:253-271.e13, DOI 10.1016/j.stem.5.12.013, PMID 41529691, Wiki.js Id 1678, NocoDB row 700, SeaFile PDF https://fb.biokingdom.top/f/861202f029004d75b456/?dl=1. Deep-read at [`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`](/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md).
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- Notes: Sharma 2026 records vascularized retinal organoid (vRO) W31 ON/OFF/ON-OFF light responses using **60-channel MCS MEA2100-Lite** (not HD-MEA) — 60 channels at 32 kHz, no HD spatial resolution. The RGC fraction (W18: 18.2% vs 1.21% ctrl-RO) and the W31 light responses are clinically meaningful, but the MEA is bottom-surface-only (no 3D spatial resolution). Robin's own flywheel audit flagged product_relevance.rating=4 for 3Brain HD-MEA on the basis that "technical route is transferable" — but the actual technical transfer requires verifying that 3Brain's Accura-3D chip supports opsin + optogenetic + light-response recording at week-31+ retinal organoid maturity (long-duration stability). Without this confirmation, the cross-sell pitch to 3Brain's retinal-organoid accounts is theoretical. Future agents pitching Sharma 2026 to 3Brain prospects should verify the technical route end-to-end before committing.
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<!--
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Structure for new entries:
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@@ -1,7 +1,8 @@
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---
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type: "Reference"
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title: "Personal Logistics"
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openwiki_generated: true
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description: "Personal errands, appointments, pickups, travel, household/life-admin deadlines, and other non-work logistics. Work commitments live in /commitments.md."
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tags: [personal-logistics, life-admin, travel]
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---
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# Personal Logistics
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---
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type: "Reference"
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title: "Sources"
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openwiki_generated: true
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description: "Per-connector evidence indexes and ingestion coverage for the local knowledge wiki; durable synthesis lives on canonical pages."
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tags: [sources, connectors, evidence, ingestion]
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---
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# Sources
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@@ -13,7 +14,8 @@ Per-connector evidence indexes. Each connector gets its own page (for example `g
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| Connector | Page | Status |
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| --- | --- | --- |
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| Hacker News (`hackernews-1`, LLM-agent topics) | [/sources/hackernews.md](/sources/hackernews.md) | active |
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| Git repo (`obsidian-robin`, Obsidian vault) | [/sources/git-repo.md](/sources/git-repo.md) | active |
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| Git repo (`git-repo-1`, Obsidian vault + OpenWiki wiki) | [/sources/git-repo.md](/sources/git-repo.md) | active (last 2026-08-08 18:11 UTC) |
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| Web Search (`web-search-1`, Tavily) | [/sources/web-search.md](/sources/web-search.md) | active (latest pull 2026-08-03; 2026-08-08 update skipped — connector not enabled, `TAVILY_API_KEY` missing) |
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Additional connectors appear here automatically once they are authenticated and ingested at least once.
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@@ -25,9 +27,9 @@ Additional connectors appear here automatically once they are authenticated and
|
||||
| Slack | not configured | `openwiki auth slack` | Needs `search:read` for definitive self-message search; otherwise falls back to recent conversations. |
|
||||
| Notion | not configured | Notion MCP credentials | Discovery via `openwiki_list_mcp_tools`; do not guess tool names. |
|
||||
| X / Twitter | not configured | `OPENWIKI_X_ACCESS_TOKEN` via `openwiki auth x` | Streams: `home_timeline`, `user_posts`, `mentions`, `bookmarks`, `list_posts`. |
|
||||
| Web Search | not configured | `TAVILY_API_KEY` | Tavily via LangChain; reads configured queries. |
|
||||
| Web Search | **active** (`web-search-1`) | `TAVILY_API_KEY` (currently empty) | Tavily via LangChain; reads configured queries. Latest successful pull 2026-08-03 18:08 UTC; the 2026-08-08 update was skipped because the connector was not enabled. Evidence at [/sources/web-search.md](/sources/web-search.md). |
|
||||
| Hacker News | **active** (`hackernews-1`) | _(public, no auth)_ | Public feeds (`top`, `new`, `best`) + Algolia HN search queries. Evidence at [/sources/hackernews.md](/sources/hackernews.md). |
|
||||
| Git repo | **active** (`obsidian-robin`) | local repo path | Local Obsidian vault under `~/.openclaw/workspace`. Writes compact manifest; repo itself is source of truth. Evidence at [/sources/git-repo.md](/sources/git-repo.md). |
|
||||
| Git repo | **active** (`git-repo-1`) | local repo path | Local Obsidian vault at `/home/ldw/workspace` + OpenWiki wiki at `/home/ldw/.openwiki/wiki` (two configured repos per `~/.openwiki/connectors/git-repo/config.json`). Writes compact manifest; repo itself is source of truth. Evidence at [/sources/git-repo.md](/sources/git-repo.md). Last updated 2026-08-08 18:11 UTC. |
|
||||
|
||||
## How new source pages get created
|
||||
|
||||
|
||||
+18
-3
@@ -1,7 +1,8 @@
|
||||
---
|
||||
type: "Reference"
|
||||
title: "Agents 代理商档案索引 — 跨 agent CRM 同步"
|
||||
openwiki_generated: true
|
||||
description: "Cross-agent index of the Obsidian vault 02-Clients/Agents/* profiles (which agents Robin is actively working with, mapped by vendor product line). Base identity only — sensitive fields (phone / WeChat / email / end-customer list / opportunity value) live only in the private vault. Updated 2026-08-07 with _known_associations.md product-line → agent → end-customer mapping."
|
||||
tags: [agents, distributors, crm, celvivo, 3brain, cellink, femtobiomed, source]
|
||||
---
|
||||
|
||||
# Agents 代理商档案索引 — 跨 agent CRM 同步
|
||||
@@ -9,7 +10,7 @@ openwiki_generated: true
|
||||
> 数据源: Obsidian vault `02-Clients/Agents/*.md` (git-repo connector 自动同步)
|
||||
> 用途: MiniMax code / Hermes 跨 agent 问 "Robin 当前在跟哪些代理商 / 谁在帮推什么产品"
|
||||
> 更新: 自动（`~/.openwiki/update-sources.sh` 每天 02:00 拉一次 mtime,数据写入本页后 commit + push Gitea）
|
||||
> 上次同步: **2026-07-28**
|
||||
> 上次同步: **2026-07-28** (current); 2026-08-07 hook 4 partial resolution via `_known_associations.md` (see below)
|
||||
|
||||
## 4 大产品线
|
||||
|
||||
@@ -24,7 +25,7 @@ openwiki_generated: true
|
||||
|
||||
| 姓名 | 角色 | 代理商品牌 | 主推产品 | 首次记录 | 状态 | Vault 路径 |
|
||||
|---|---|---|---|---|---|---|
|
||||
| 董慧群 | 技术同事 | 待补 | CelVivo (ClinoStar / ClinoReactor) | 2026-07-28 | active | `02-Clients/Agents/董慧群.md` |
|
||||
| 董慧群 | 技术同事 | 待补 (8-07 hook 4 候选: **济南成全生物科技 (曹沛起)**) | CelVivo (ClinoStar / ClinoReactor) | 2026-07-28 | active | `02-Clients/Agents/董慧群.md` |
|
||||
|
||||
## 跟其他工具的互补关系
|
||||
|
||||
@@ -56,3 +57,17 @@ openwiki_generated: true
|
||||
- **02-Clients/Agents/** 现只有 1 个条目 — Robin 大部分代理商应该是已有的，需要主动说"把 X 也加进来"
|
||||
- 建议 Robin 每接一个新代理商 / 新联系人时 1 句话提示，我立即同步两边
|
||||
- 是否要加 **End-Customers/** 同步索引到 OpenWiki（按同样模式）？目前 `02-Clients/End-Customers/西南医科大学心研所-殴贤红.md` 已存在但未在本文件列
|
||||
|
||||
## 2026-08-07 关联索引 (Hermes hook 4)
|
||||
|
||||
`02-Clients/Agents/_known_associations.md` (commit `4b237a82`, Hermes Agent 2026-08-07 hook 4) maps 现有关联 to 259-dealer 2026-08-07 baseline. Public index (privacy rule preserved):
|
||||
|
||||
| 产品线 | 关联代理 / 中间方 | 关联客户 / 商机 |
|
||||
|---|---|---|
|
||||
| CelVivo | **济南成全生物科技 (曹沛起)** — 华北 + 山东 跨区 | 董慧群 (技术同事) — 8-07 候选 |
|
||||
| FemtoBiomed | **9X Bio (汇佰生物)** — 中间方 (不在 259 dealer list) | TriArm Therapeutics (翁靖傑 上海 CGT/CAR-T, 128 万 Phase1 / 8-10 至 8-14 现场 demo) |
|
||||
| 3Brain | 0 家代理 | 11+ end-customer dossiers (西南医大 殴贤红 pending 成都 dealer 2选1) |
|
||||
| Cellink | 0 家代理 | — |
|
||||
| FemtoBiomed (direct) | 0 家代理 | (9X Bio 中间方 handles) |
|
||||
|
||||
See [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) § "8-07 新增" for full mapping + 待补缺口. Open-question `agent-dong-huiqun-celvivo` and commitment `dong-huiqun-ji-nan-chengquan-link` track the 董慧群 → 济南成全 confirmation.
|
||||
|
||||
@@ -1,61 +1,86 @@
|
||||
---
|
||||
type: "Reference"
|
||||
title: "全国经销商地图 · 2026-07-24 时点"
|
||||
openwiki_generated: true
|
||||
title: "全国经销商地图 (2026-08-07 时点)"
|
||||
description: "Compact index of Robin's 2026-08-07 China distributor baseline (259 dealers across 7 regions, replacing 261 in the 2026-07-24 baseline) plus the new product-association index _known_associations.md. Surfaces CelVivo ClinoStar → 济南成全 + FemtoBiomed CellShot → 9X Bio → TriArm Therapeutics chain. Routes pricing-sensitive fields to the private Obsidian vault per /sources/agents.md privacy rule."
|
||||
resource: "/home/ldw/workspace/02-Clients/Agents/全国经销商地图-2026-0807.md"
|
||||
tags:
|
||||
- distributors
|
||||
- china
|
||||
- 2026
|
||||
- vendors
|
||||
- source
|
||||
---
|
||||
|
||||
# 全国经销商地图 · 2026-07-24 时点
|
||||
# 全国经销商地图 · 2026-08-07 时点
|
||||
|
||||
> **数据源**: Obsidian vault `02-Clients/Agents/*.md`（git-repo connector 自动同步，2026-08-07 写入）
|
||||
> **覆盖范围**: 全国 7 大区域 / 261 家生命科学仪器经销商
|
||||
> **整理**: Hermes Agent（Robin 2026-08-07 上传 `2026经销商信息统计表-全国0724.xlsx`）
|
||||
> **数据源**: Obsidian vault `02-Clients/Agents/*.md`（git-repo connector 自动同步，2026-08-07 写入 — 替换 2026-07-24 baseline）
|
||||
> **覆盖范围**: 全国 7 大区域 / **259** 家生命科学仪器经销商（汇总表口径；明细表 261：差 2 家 = 华北表 74 vs 汇总 72）
|
||||
> **整理**: Hermes Agent（Robin 2026-08-07 11:11 上传 `b7f52af896c1e3a9.xlsx`）
|
||||
> **关联索引**: `02-Clients/Agents/_known_associations.md`（2026-08-07 added — 5 命中产品-代理映射）
|
||||
|
||||
## 隐私边界
|
||||
|
||||
按 [[sources/agents.md]] 既定规则，本文件**只含基础身份**：
|
||||
按 [`/sources/agents.md`](/sources/agents.md) 既定规则，本文件**只含基础身份**：
|
||||
- ✅ 公司名 / 区域 / 主营品牌关键词 / 主战场
|
||||
- ❌ **不**含：电话 / 微信 / 邮箱 / 联系人姓名 / 终端客户清单 / 商机金额 / 销售人数
|
||||
|
||||
**详细联系方式** → 必须读 Obsidian vault `02-Clients/Agents/{区域}-2026-0724.md`（git 私有）
|
||||
**详细联系方式** → 必须读 Obsidian vault `02-Clients/Agents/{区域}-2026-0807.md`（git 私有）
|
||||
|
||||
## 关键统计
|
||||
|
||||
| 维度 | 数值 |
|
||||
|---|---|
|
||||
| 总经销商数 | **261** 家（明细表口径，比汇总表"公司数量"259 多 2 家 — 差异来自华北表）|
|
||||
| 总经销商数 | **259** 家（汇总表口径；明细表 261 — 差 2 家 = 华北表 74 vs 汇总 72）|
|
||||
| 覆盖区域 | 7 大区 |
|
||||
| 平均每地区 | 37 家 |
|
||||
| 上次 baseline | 2026-07-24（261 家） |
|
||||
| 净变更 | -2 家（华北：74 → 72） |
|
||||
|
||||
| 地区 | 家数 | 占% | 主战场 |
|
||||
|---|---|---|---|
|
||||
| 华北 | 74 | 28.4% | 北京 (54家) |
|
||||
| 华东 | 68 | 26.1% | 上海 (53家) |
|
||||
| 华南 | 62 | 23.8% | 广州 (44家) |
|
||||
| 山东 | 25 | 9.6% | 济南 (22家) |
|
||||
| 湖北 | 19 | 7.3% | 武汉 (12家) |
|
||||
| 西北 | 6 | 2.3% | 西安 (6家) |
|
||||
| 西南 | 7 | 2.7% | 重庆 (3家) |
|
||||
| 地区 | 家数 (8-07) | 家数 (7-24) | 净变更 | 主战场 |
|
||||
|---|---:|---:|---:|---|
|
||||
| 华北 | 72 | 74 | -2 | 北京 (54家) |
|
||||
| 华东 | 68 | 68 | 0 | 上海 (53家) |
|
||||
| 华南 | 62 | 62 | 0 | 广州 (44家) |
|
||||
| 山东 | 25 | 25 | 0 | 济南 (22家) |
|
||||
| 湖北 | 19 | 19 | 0 | 武汉 (12家) |
|
||||
| 西北 | 6 | 6 | 0 | 西安 (6家) |
|
||||
| 西南 | 7 | 7 | 0 | 重庆 (3家) |
|
||||
| **TOTAL** | **259** | **261** | **-2** | — |
|
||||
|
||||
### 8-07 baseline 独有的数据异常
|
||||
|
||||
- **济南成全生物科技有限公司 (曹沛起)** 同时登记在 **华北表 + 山东表**（geographic
|
||||
cross-region duplicate，合法 — 山东公司辐射华北是常见经销模式）。 This is the
|
||||
**only CelVivo ClinoStar agent** in the 259-dealer list — the hook to
|
||||
cross-reference with `02-Clients/Agents/董慧群.md`（见
|
||||
[`/open-questions.md`](/open-questions.md) `agent-dong-huiqun-celvivo`）
|
||||
- **华北表 序号 63 / 67** 两个空 company-name 字段（继承 from 2026-07-24
|
||||
baseline）；明细表 74 vs 汇总表 72 的差 2 家，就是这 2 行
|
||||
|
||||
## 与 4 大产品线的潜在关联
|
||||
|
||||
> 以下统计仅展示**代理过我们 4 大产品线品牌**的经销商家数。**不等于**Robin 实际在跟的代理商 — 那份见 [[sources/agents.md]]。
|
||||
> 以下统计仅展示**代理过我们 4 大产品线品牌**的经销商家数。**不等于**Robin 实际在跟的代理商 — 那份见 [`/sources/agents.md`](/sources/agents.md)。
|
||||
|
||||
| 产品线 | 涉及品牌 | 全国关联经销商数 |
|
||||
|---|---|---|
|
||||
| CelVivo (ClinoStar / ClinoReactor) | CelVivo / ClinoStar | 待详细匹配 |
|
||||
| 3Brain (HD-MEA) | 3Brain | 待详细匹配 |
|
||||
| Cellink (BIO X) | Cellink | 待详细匹配 |
|
||||
| FemtoBiomed (CellShot / PROLIVA) | Femtobiomed / CellShot | 待详细匹配 |
|
||||
| 产品线 | 涉及品牌 | 全国关联经销商数 | 8-07 命中 |
|
||||
|---|---|---:|---|
|
||||
| CelVivo (ClinoStar / ClinoReactor) | CelVivo / ClinoStar | 1 | **济南成全生物科技 (曹沛起)** — 华北 + 山东 (跨区重复) |
|
||||
| FemtoBiomed (CellShot / PROLIVA) | Femtobiomed / CellShot | 0 | (9X Bio / 汇佰生物 is direct intermediate, 不在 259 dealer list) |
|
||||
| 3Brain (HD-MEA) | 3Brain | 0 | — |
|
||||
| Cellink (BIO X) | Cellink | 0 | — |
|
||||
|
||||
**详细 + 客户-代理映射：** 见 `02-Clients/Agents/_known_associations.md`（2026-08-07 added）。
|
||||
|
||||
## 详细分地区索引（不含敏感字段）
|
||||
|
||||
- 华北 (74 家) — 见 Obsidian vault `02-Clients/Agents/华北-2026-0724.md`
|
||||
- 华东 (68 家) — 见 Obsidian vault `02-Clients/Agents/华东-2026-0724.md`
|
||||
- 华南 (62 家) — 见 Obsidian vault `02-Clients/Agents/华南-2026-0724.md`
|
||||
- 山东 (25 家) — 见 Obsidian vault `02-Clients/Agents/山东-2026-0724.md`
|
||||
- 湖北 (19 家) — 见 Obsidian vault `02-Clients/Agents/湖北-2026-0724.md`
|
||||
- 西北 (6 家) — 见 Obsidian vault `02-Clients/Agents/西北-2026-0724.md`
|
||||
- 西南 (7 家) — 见 Obsidian vault `02-Clients/Agents/西南-2026-0724.md`
|
||||
- 华北 (72 家) — 见 Obsidian vault `02-Clients/Agents/华北-2026-0807.md`
|
||||
- 华东 (68 家) — 见 Obsidian vault `02-Clients/Agents/华东-2026-0807.md`
|
||||
- 华南 (62 家) — 见 Obsidian vault `02-Clients/Agents/华南-2026-0807.md`
|
||||
- 山东 (25 家) — 见 Obsidian vault `02-Clients/Agents/山东-2026-0807.md`
|
||||
- 湖北 (19 家) — 见 Obsidian vault `02-Clients/Agents/湖北-2026-0807.md`
|
||||
- 西北 (6 家) — 见 Obsidian vault `02-Clients/Agents/西北-2026-0807.md`
|
||||
- 西南 (7 家) — 见 Obsidian vault `02-Clients/Agents/西南-2026-0807.md`
|
||||
|
||||
> **2026-07-24 baseline 文件** (`*2026-0724.md` × 7 + `全国经销商地图-2026-0724.md`) 仍 in repo but 已被 8-07 替换。Robin upload 2026-08-07 11:11 时是 **8-04 同名 + 新增 2-3 家** = 259 汇总口径。
|
||||
|
||||
## 品牌关键词地图（粗略）
|
||||
|
||||
@@ -84,11 +109,61 @@ openwiki_generated: true
|
||||
| Agilent | 3 | 1 | 0 | 0 | 2 | 0 | 0 | 0 |
|
||||
| Sartorius | 3 | 1 | 0 | 0 | 1 | 0 | 0 | 1 |
|
||||
|
||||
## 8-07 新增：`_known_associations.md` 索引
|
||||
|
||||
`02-Clients/Agents/_known_associations.md` 是 2026-08-07 由 Hermes Agent
|
||||
hook 4（4 个经销商管理 Hook 升级）输出的产品-代理-客户映射。摘录：
|
||||
|
||||
### CelVivo / ClinoStar 链
|
||||
|
||||
| 项 | 内容 |
|
||||
|---|---|
|
||||
| 代理 | **济南成全生物科技有限公司 (曹沛起)** — 华北 + 山东 跨区重复登记 |
|
||||
| 关联中间方 | 董慧群 (CelVivo 技术同事) — agency 待 Robin 确认 |
|
||||
| 关联客户 | (待 Robin 确认) |
|
||||
| 关联商机 | (待 Robin 确认) |
|
||||
|
||||
### FemtoBiomed (CellShot / PROLIVA) 链
|
||||
|
||||
| 项 | 内容 |
|
||||
|---|---|
|
||||
| 中间方 | **9X Bio (汇佰生物)** — FemtoBiomed CellShot / PROLIVA 中国中间方 |
|
||||
| 259 dealer 命中 | 0 家 (9X Bio 直接对接 TriArm, 不在代理渠道表里) |
|
||||
| 关联终端客户 | **TriArm Therapeutics (翁靖傑, 上海 CGT/CAR-T)** |
|
||||
| 关联商机 | `02-Active-Deals/CellShot-TriArm-Demo-*` (4 个文件, 7-17 会议 + 7-20 计划 v1/v2) |
|
||||
| 备注 | 128 万 Phase1 / 8-10 至 8-14 现场 demo |
|
||||
|
||||
### 西南医科大学心研所 殴贤红 → 2 选 1
|
||||
|
||||
| 项 | 内容 |
|
||||
|---|---|
|
||||
| 地区 | 四川泸州 |
|
||||
| 候选代理 A | **成都百乐 (杨军)** — 覆盖川渝黔藏 · 1亿/钻石 · 主营 Bio-Rad/Sartorius/Oxford Nanopore/Cytek/Leica |
|
||||
| 候选代理 B | **成都立德赛** — 覆盖川渝云贵陕 |
|
||||
| 关联商机 | (待 Robin 决策) |
|
||||
| 推荐 | **先联系 成都百乐** (钻石级 1亿, 主营匹配度更高) |
|
||||
|
||||
### 产品线代理映射（259 dealer 表已知）
|
||||
|
||||
| 产品线 | 命中代理 | 关联客户 |
|
||||
|---|---|---|
|
||||
| CelVivo | 济南成全 (曹沛起) | 董慧群关联 |
|
||||
| FemtoBiomed | 0 (9X Bio 中间方) | TriArm |
|
||||
| 3Brain | 0 | — |
|
||||
| Cellink | 0 | — |
|
||||
|
||||
### 待补缺口（Robin 优先补全）
|
||||
|
||||
1. 董慧群 是 济南成全的哪个具体技术同事? 还是另一家代理?
|
||||
2. 西南医大 殴贤红 → 成都百乐 还是 成都立德赛?
|
||||
3. 邓昊伦 (02-Contacts/) 蛇类神经方向 → 3Brain HD-MEA 拜访?
|
||||
4. 259 dealer 表里**无 3Brain / Cellink 代理** → 缺销售漏掉了 or 要主动找?
|
||||
|
||||
## 与现有 sources/agents.md 关系
|
||||
|
||||
- `sources/agents.md` 记录**Robin 实际在跟的代理商**（按 4 大产品线维度，目前 1 个: 董慧群）→ "在跟"
|
||||
- `sources/distributors-china-2026.md`（本文件）记录**全国 261 家渠道全量** → "全景"
|
||||
- 两份互补，**不可合并**：合并会污染"在跟"列表（混入未接触的 260 家）
|
||||
- [`/sources/agents.md`](/sources/agents.md) 记录**Robin 实际在跟的代理商**（按 4 大产品线维度，目前 1 个: 董慧群）→ "在跟"
|
||||
- `/sources/distributors-china-2026.md`（本文件）记录**全国 259 家渠道全量 (8-07 baseline)** + 8-07 新增 `_known_associations.md` 索引 → "全景 + 关联"
|
||||
- 两份互补，**不可合并**：合并会污染"在跟"列表（混入未接触的 258 家）
|
||||
|
||||
## 关键数据缺口
|
||||
|
||||
@@ -103,4 +178,5 @@ openwiki_generated: true
|
||||
---
|
||||
|
||||
*由 Hermes Agent 自动整理 · 2026-08-07*
|
||||
*本文件不含敏感信息，按 [[sources/agents.md]] 隐私规则*
|
||||
*本文件不含敏感信息，按 [`/sources/agents.md`](/sources/agents.md) 隐私规则*
|
||||
*Raw manifest: `~/.openwiki/connectors/git-repo/raw/2026-08-08T18-11-31-856Z/manifest.json`*
|
||||
|
||||
+224
-172
@@ -1,89 +1,154 @@
|
||||
---
|
||||
type: "Reference"
|
||||
title: "Git repo — evidence index (Obsidian vault, Robin)"
|
||||
openwiki_generated: true
|
||||
description: "Compact manifest of Robin's Obsidian vault + the local OpenWiki wiki, ingested through the local git-repo connector. Two configured repos: obsidian-vault at /home/ldw/workspace (main branch, HEAD d7df3830, 2026-08-08) and openwiki-wiki at /home/ldw/.openwiki/wiki (main branch, HEAD c94940c7, 2026-08-08). This page is a navigation index — content ingestion (paper deep reads, sales scripts, customer files) happens via the Hermes skill and RAGFlow, not here."
|
||||
resource: "~/.openwiki/connectors/git-repo/config.json"
|
||||
tags: [git-repo, evidence, vault, openwiki-wiki, source]
|
||||
---
|
||||
|
||||
# Git repo — evidence index (Obsidian vault, Robin)
|
||||
# Git repo — evidence index (Obsidian vault + OpenWiki wiki)
|
||||
|
||||
Compact manifest of Robin's Obsidian vault, ingested through the local `git-repo`
|
||||
connector. This page is a **navigation index** — content ingestion (paper deep
|
||||
reads, sales scripts, customer files) happens via the Hermes skill and RAGFlow,
|
||||
not here. Keep this page terse and structural; it should help locate things in
|
||||
the vault, not summarize their content.
|
||||
Compact manifest of the two local git repos configured under the
|
||||
`git-repo` connector: Robin's Obsidian vault and the local OpenWiki
|
||||
wiki. This page is a **navigation index** — content ingestion (paper
|
||||
deep reads, sales scripts, customer files) happens via the Hermes skill
|
||||
and RAGFlow, not here. Keep this page terse and structural; it should
|
||||
help locate things in the vault, not summarize their content.
|
||||
|
||||
## Connector
|
||||
|
||||
- **Instance:** `obsidian-robin` (source id `obsidian-robin-1`)
|
||||
- **Repo path:** `/mnt/c/Users/20864/.openclaw/workspace`
|
||||
- **Branch:** `main`
|
||||
- **HEAD:** `1a81e485b6f8a4496122464f1151702d09f03cf0` (2026-07-29, unchanged
|
||||
since 2026-07-29 — no new commits have landed on `main` in the last five
|
||||
fetches, this run included)
|
||||
- **Ahead of origin/main:** 9 commits (3 CellShot-TriArm-Demo plans + 4 dated
|
||||
2026-07-28: Hodge 2025 / Lee 2025 / Parate 2020 deep reads + 董慧群
|
||||
CelVivo distributor technical-contact profile + 2 dated 2026-07-29:
|
||||
`81671c69` Organoids 2026 综述 feat deep-read + `1a81e485` SOP-rewrite
|
||||
pass on the same file — un-pushed as of this run)
|
||||
- **Auth:** local path only — no remote, no credentials
|
||||
- **Latest fetch:** `2026-08-03T18:13:23Z` (HEAD unchanged at `1a81e485`;
|
||||
no new commit, working-tree path, or tracked/untracked file mtime in the
|
||||
last 24 hours was observed. The `03-Resources/ITX-24h-Host/` directory and
|
||||
the 5 previously-untracked files remain present; the
|
||||
`skills/openclaw-workspace` modified/submodule-dirty status also remains
|
||||
unchanged. The current manifest is byte-identical to the
|
||||
`2026-08-02T18-11-41-399Z` fetch except for the `generatedAt` timestamp —
|
||||
vault truly has had 0 changes in the last 24 hours.)
|
||||
- **Raw manifest:** `~/.openwiki/connectors/git-repo/raw/2026-08-03T18-13-23-151Z/manifest.json`
|
||||
- **Source instance:** `git-repo-1` (configured under
|
||||
`~/.openwiki/connectors/git-repo/config.json`)
|
||||
- **Configured repos:**
|
||||
- `obsidian-vault` → `/home/ldw/workspace` (Robin Obsidian vault, on
|
||||
`main`, HEAD `d7df3830a28a48b0129a46729ab2357e231a2ec5` as of
|
||||
2026-08-08).
|
||||
- `openwiki-wiki` → `/home/ldw/.openwiki/wiki` (the OpenWiki knowledge
|
||||
base itself, on `main`, HEAD `c94940c7d24bdf77680822a86c81355acff93ebf`
|
||||
as of 2026-08-08).
|
||||
- **Auth:** local paths only — no remote, no credentials.
|
||||
- **Latest fetch:** `2026-08-08T18:11:31Z` (raw manifest
|
||||
`~/.openwiki/connectors/git-repo/raw/2026-08-08T18-11-31-856Z/manifest.json`).
|
||||
- **Source config:** `~/.openwiki/connectors/git-repo/config.json`
|
||||
- **State:** `~/.openwiki/connectors/git-repo/state.json` records
|
||||
`latestIds` per repo; the 2026-08-08 fetch bumped both `obsidian-vault`
|
||||
(from `2341383e` to `d7df3830`) and `openwiki-wiki` (from `45af5a4` /
|
||||
`9e80977` to `c94940c7`).
|
||||
|
||||
## Working-tree status
|
||||
## obsidian-vault — working-tree status (2026-08-08)
|
||||
|
||||
- **Dirty:** yes
|
||||
- **Modified:** `skills/openclaw-workspace` — the nested workspace remains dirty
|
||||
at recorded commit `4e81a914b5f4ed52d88e0b31476354f92fcd4be7`. The current
|
||||
outer manifest reports the same path-level modification as the prior pull;
|
||||
content-level ingestion is intentionally out of scope for this navigation
|
||||
index.
|
||||
- **Untracked (1 directory + 5 files):**
|
||||
- `03-Resources/ITX-24h-Host/ITX_24h_Host_v18_Config_2026-07-31.md`
|
||||
— *carryover from the prior fetch.* Robin's 24h ITX host build plan (mATX + i5-12400
|
||||
+ DDR4-2666 32G + 板载 Realtek 1Gb + Intel PRO/1000 GT 双网卡
|
||||
NAS 隔离) for hosting Hermes Agent + AI workflow stack. Budget
|
||||
¥2,985.82 / 10/11 parts arrived. See "Notable entities" below for
|
||||
routing.
|
||||
- `04-Literature/Deep-Reads/3Brain/3Brain_Sample_Holder_Set_PressNet_2026-07-07.md`
|
||||
— 3Brain UK GB2624872 Sample Holder Set / CorePlate 压网装置 note
|
||||
(load force 250–1250 µN). Date stamp 2026-07-07. *(carryover from prior pull)*
|
||||
- `04-Literature/Deep-Reads/3Brain/Raji_2026_hMOs_dopaminergic_3Brain_MEA_2026-07-27.md`
|
||||
— Raji 2026 Mol Psychiatry: WNT-modulated hMOs + 3Brain HD-MEA
|
||||
(BioCAM DupleX + Accura-3D, 4096 electrodes); TH+ 58% at 12 weeks.
|
||||
Date stamp 2026-07-27. *(carryover from prior pull)*
|
||||
- `04-Literature/Deep-Reads/Cellink/Tasevska_2025_HCTZ_3D_printed_extended_release_2026-07-27.md`
|
||||
— Tasevska 2025 EJPS: SSE-printed HCTZ extended-release tablets,
|
||||
BIO X-compatible; 12 h release 85% vs 58% (pressed), 6-month
|
||||
stability ≥95%. Date stamp 2026-07-27. *(carryover from prior pull)*
|
||||
- `04-Literature/Deep-Reads/Celvivo/Bosnjakovic_2025_PAH_3D_spheroid_CelVivo_ClinoStar_2026-07-27.md`
|
||||
— Bosnjakovic 2025 bioRxiv: HepG2 3D spheroid (ClinoStar dynamic
|
||||
culture, 21-day maturation) + BaP/BBF exposure, 4 metabolomic
|
||||
markers only visible in 3D. Date stamp 2026-07-27. *(carryover from prior pull)*
|
||||
- `OpenWiki速查手册_2026-07-27.md` (vault root) — Robin's OpenWiki
|
||||
cheat sheet ("一天 6 次对话的完整沉淀"). Date stamp 2026-07-27.
|
||||
*(carryover from prior pull)*
|
||||
- **Branch:** `main`
|
||||
- **HEAD:** `d7df3830a28a48b0129a46729ab2357e231a2ec5` (obsidian-vault top
|
||||
of new remote / post-8-07 sweep)
|
||||
- **Ahead of origin/main:** 9 commits (the 2026-07-29 / 2026-07-28 cluster
|
||||
was extended by 4–5 new deep-read commits on 2026-08-07 / 2026-08-08).
|
||||
- **Dirty:** yes — 8 untracked 8-07 distributor/agent files + the
|
||||
literature-stage files Robin works on between commits.
|
||||
- **Working-tree status (raw manifest, abbreviated):**
|
||||
|
||||
This run records **0 new commits** on `main` — HEAD is still `1a81e485`,
|
||||
unchanged from the 2026-08-02T18:11:41 fetch. The current manifest is
|
||||
byte-identical to the prior fetch except for the `generatedAt` timestamp
|
||||
(it still reports the existing `skills/openclaw-workspace` modification, and
|
||||
the ITX directory plus five untracked files listed below are carryovers; no
|
||||
new path was observed in this run). Since zero new commits, the "vault
|
||||
fresh" staleness rule (7-day window) does not need to fire — it is already
|
||||
in the clear based on the 2026-07-28 / 2026-07-29 commit cluster documented
|
||||
in the prior pull.
|
||||
Companion deep-read pages already exist for the three carryover vendor-paper
|
||||
notes: `/sources/literature-raji-2026-deepread.md`,
|
||||
`/sources/literature-tasevska-2025-deepread.md`, and
|
||||
`/sources/literature-cel-bosnjakovic-2025-pah-deepread.md`.
|
||||
| Status | Path |
|
||||
| --- | --- |
|
||||
| `M` (committed 2026-08-08) | `obsidian-vault/04-Literature/Deep-Reads/Cells/fernandez-vallone-2026-thsdc-brain-organoids.md` (cells paper v2: 双 H1 + 5张真图) |
|
||||
| `M` (committed 2026-08-07) | `obsidian-vault/04-Literature/Deep-Reads/Microbioreactor/literature-microbioreactor-eukaryotic-cell-biomedical-2026.md` (fix v2 with SeaFile links) |
|
||||
| `??` (untracked) | `02-Clients/Agents/全国经销商地图-2026-0807.md` |
|
||||
| `??` (untracked) | `02-Clients/Agents/华北-2026-0807.md` |
|
||||
| `??` (untracked) | `02-Clients/Agents/华东-2026-0807.md` |
|
||||
| `??` (untracked) | `02-Clients/Agents/华南-2026-0807.md` |
|
||||
| `??` (untracked) | `02-Clients/Agents/山东-2026-0807.md` |
|
||||
| `??` (untracked) | `02-Clients/Agents/湖北-2026-0807.md` |
|
||||
| `??` (untracked) | `02-Clients/Agents/西北-2026-0807.md` |
|
||||
| `??` (untracked) | `02-Clients/Agents/西南-2026-0807.md` |
|
||||
| `??` (untracked) | `04-Literature/Deep-Reads/Brain/2026-08-06_Parfitt_GM_et_al_NatCommun_2024_DJ1_LOF_midbrain_organoid_PD.md` |
|
||||
| `??` (untracked) | `Liu2026_NBME_shape_conformal_organoid.md` |
|
||||
| `??` (untracked) | `Miao2025_Cell_v2.md` |
|
||||
| `??` (untracked) | `Miao2025_Cell_vascularized_organoid.md` |
|
||||
| `??` (untracked) | `Microbioreactor_2026_Rosero_FrontBioeng.md` |
|
||||
| `??` (untracked) | `dify精读进度-20260805.md` |
|
||||
| `??` (untracked) | `literature_deepread_v6.py` |
|
||||
| `??` (untracked) | `obsidian-vault/rustdesk-selfhosted-2026-08-05.md` |
|
||||
| `??` (untracked) | `retinal_organoid_deep_read_2026-08-07.md` |
|
||||
| `??` (untracked) | `文悦精读流水线.yml` + v2/v3/v4/v5-clean variants |
|
||||
|
||||
The 8 untracked `*2026-0807.md` files in `02-Clients/Agents/` are the
|
||||
**2026-08-07 distributor baseline refresh** — see the "Distributor
|
||||
map refresh (2026-08-07)" section below for synthesis.
|
||||
|
||||
### Recent commits (latest first)
|
||||
|
||||
| Date | Hash | Note |
|
||||
| --- | --- | --- |
|
||||
| 2026-08-08 | `d7df3830` | cells paper v2: 双 H1 + 5张真图 (xref) — Fernandez Vallone 2026 |
|
||||
| 2026-08-08 | `6c16dc05` | 精读: Fernandez Vallone 2026 Cells hiPSC 脑类器官 THSDC |
|
||||
| 2026-08-07 | `65fef021` | fix: v2 with SeaFile links — Microbioreactor 2026 |
|
||||
| 2026-08-07 | `18bee69f` | feat: Microbioreactor design 2026 Front Bioeng Biotechnol Mini Review (PMID 42516424) |
|
||||
| 2026-08-08 | `1614ccf9` | fix: v11 - forwarding per skill template (Liu 2026) |
|
||||
| 2026-08-08 | `a7cfb8a4` | fix: final - per Research SOP strict + clean internal traces (Liu 2026) |
|
||||
| 2026-08-08 | `d1e8c6dd` | fix: v5 - per Research SOP + page 946 benchmark (Liu 2026) |
|
||||
| 2026-08-08 | `b7882b81` | fix: v4 - add forward message (Liu 2026) |
|
||||
| 2026-08-08 | `84e93402` | fix: v3 - Fig 3 restored from page 6, audit table removed (Liu 2026) |
|
||||
| 2026-08-08 | `a69ad9c4` | literature: liu 2026 NBME shape-conformal organoid |
|
||||
| 2026-08-08 | `1c05eee7` | literature: miao 2025 cell organoid vascularization v2 |
|
||||
| 2026-08-08 | `a0810433` | 精读: Sharma K 2026 Cell Stem Cell 视网膜类器官血管化RGC存活与功能成熟 |
|
||||
| 2026-07-29 | `2341383e` | fix(hook4): 湖北行去掉 'Robin 8 月出差高发地' 残留 (Robin 真实出差意图) |
|
||||
| 2026-07-29 | `aa8fd2bc` | fix(hook4): 改标题 '下次出差' → '按 xlsx 缺口', Robin 后续自规划出差路径 |
|
||||
| 2026-07-29 | `4b237a82` | feat(hook): 4 个经销商管理 Hook 升级 |
|
||||
| 2026-07-29 | `b9da34dc` | fix(literature): Organoids 2026 综述 - 按 literature-deep-read-review SOP 重写 |
|
||||
| 2026-07-29 | `0cd44fa0` | feat(literature): 精读 Organoids for disease modeling and treatment 2026 综述 |
|
||||
| 2026-07-28 | `642e3dc6` | feat(agent): 新增代理商技术同事董慧群档案 (推 CelVivo 产品) |
|
||||
| 2026-07-28 | `2718e46d` | feat(literature): Parate 2020 SCRT — PEMF 增强 MSC 旁分泌功能促软骨再生 |
|
||||
| 2026-07-28 | `032de92f` | feat: 精读 Lee 2025 Front Vet Sci 犬脂肪源 MSC 3D 球体 |
|
||||
|
||||
The **2026-08-08 cluster** is the literature flywheel-sync output (Liu
|
||||
2026, Miao 2025 v2, Sharma 2026) — already indexed on
|
||||
[`/sources/literature.md`](/sources/literature.md). The
|
||||
**2026-08-07 / 2026-08-08 micro-revisions** on Liu 2026 (`a69ad9c4` →
|
||||
`1614ccf9`) are the 8-step SOP rewrite cycle (v3 → v11) Robin re-ran
|
||||
on the same paper.
|
||||
|
||||
## openwiki-wiki — working-tree status (2026-08-08)
|
||||
|
||||
- **Branch:** `main`
|
||||
- **HEAD:** `c94940c7d24bdf77680822a86c81355acff93ebf` (the
|
||||
`feat: add Microbioreactor 2026 v4` update commit for the
|
||||
literature index)
|
||||
- **Working-tree state:** 17 staged-but-not-yet-committed file changes
|
||||
(this OpenWiki run's own edits, plus 3 new literature deep-read
|
||||
synthesis pages from the 2026-08-08 flywheel-sync:
|
||||
`sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`,
|
||||
`sources/literature-miao-2025-cell-vascularization-v2-deepread.md`,
|
||||
`sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`).
|
||||
- **Auth:** local path only — no remote, no credentials.
|
||||
|
||||
### Recent commits (latest first)
|
||||
|
||||
| Date | Hash | Note |
|
||||
| --- | --- | --- |
|
||||
| 2026-08-08 | `c94940c7` | feat: add Microbioreactor 2026 v4 (PMID 42516424, ID 1696) |
|
||||
| 2026-08-08 | `7f65024` | feat: add Microbioreactor 2026 v3 (PMID 42516424) |
|
||||
| 2026-08-08 | `ea4f14a` | feat: add Microbioreactor 2026 v2 (PMID 42516424) |
|
||||
| 2026-08-08 | `a193e46` | feat: add Microbioreactor 2026 (PMID 42516424) deep-read entry |
|
||||
| 2026-08-08 | `bf90a91` | fix: liu 2026 wiki link to main path |
|
||||
| 2026-08-08 | `cf1dbe0` | fix: liu 2026 final link |
|
||||
| 2026-08-08 | `26efd2f` | fix: liu 2026 v5 link |
|
||||
| 2026-08-08 | `e18993a` | fix: liu 2026 v4 link |
|
||||
| 2026-08-08 | `b206bd9` | fix: liu 2026 v3 link |
|
||||
| 2026-08-08 | `c26dbdf` | fix: liu 2026 wiki link to v2 |
|
||||
| 2026-08-08 | `703c3d4` | literature: liu 2026 NBME shape-conformal organoid |
|
||||
| 2026-08-08 | `1b78735` | literature: miao 2025 cell v2 |
|
||||
| 2026-08-08 | `5adc406` | chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-08) |
|
||||
| 2026-08-08 | `037c5f3` | lit: add Sharma K 2026 Cell Stem Cell vRO retinal organoid (PMID 41529691) |
|
||||
| 2026-08-07 | `9e80977` | feat(openwiki): complete data flywheel activation (2026-08-07) |
|
||||
| 2026-08-07 | `45af5a4` | chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-07) |
|
||||
| 2026-08-07 | `bcd4a4f` | chore(sources): refresh NocoDB/SeaFile/Wiki.js/RAGFlow counts (sources-sync 2026-08-07) |
|
||||
| 2026-08-07 | `0bbef0f` | feat(openwiki v0.3.1 --update): generate themes 4-5 + index.md + themes/ + sources/ index (2026-08-07) |
|
||||
| 2026-08-07 | `285c53b` | feat(openwiki v0.3.1): add YAML frontmatter + install-id markers from initial init run (2026-08-07) |
|
||||
| 2026-07-24 | `3102e96` | feat(sources): 全国 261 家经销商地图 (2026-07-24, 不含敏感信息) |
|
||||
|
||||
The wiki repo is the OpenWiki output itself — it persists across
|
||||
update runs. The 2026-08-08 cluster (3 literature deep-read synthesis
|
||||
+ 11 sources-sync + 4 Liu 2026 link fixes) is the work-surface for
|
||||
the 2026-08-08 flywheel-sync, and is the canonical record of what
|
||||
was surfaced to the user during that sync.
|
||||
|
||||
## Vault navigation index
|
||||
|
||||
@@ -133,102 +198,70 @@ Markdown file counts per deep-read subfolder:
|
||||
| `Cardiac/` | 2 |
|
||||
| `Kidney/` | 2 |
|
||||
| `Retinal/` | 1 |
|
||||
| `Microbioreactor/` | 1 (new as of 2026-08-07 — Rosero 2026 Front Bioeng Biotechnol) |
|
||||
| `Cells/` | 1 (new as of 2026-08-08 — Fernandez Vallone 2026 Cells THSDC) |
|
||||
|
||||
Total ≈ 1,202 deep-read notes (+3 committed 2026-07-28 vendor/adjacent
|
||||
deep-reads since the pull before that: +2 `Other/` — Lee 2025 Front Vet Sci
|
||||
canine MSC 3D spheroid + Parate 2020 SCRT PEMF MSC paracrine cartilage;
|
||||
+1 new `RegenMed/` bucket — Hodge 2025 Bio-Block MSC 4-week comparison;
|
||||
the Organoid/ bucket is now +1 from this run's two new commits
|
||||
(`81671c69` Organoids 2026 综述 feat deep-read + `1a81e485` SOP-rewrite
|
||||
of the same file) — neither `Other/` nor `RegenMed/` changed this run).
|
||||
CelVivo, 3Brain, Cellink, and the broad `Organoid/` bucket cover Robin's
|
||||
product KB per the wiki goal focus areas (类器官培养与设备, 3D 生物打印).
|
||||
The new `RegenMed/` bucket is application-domain adjacent (Bio-Block vs.
|
||||
spheroid vs. Matrigel MSC long-term culture) and is the kind of vendor-
|
||||
adjacent signal the existing `class-organoid-3d-bioprinting` row folds in.
|
||||
Total ≈ 1,204 deep-read notes (+2 from the 2026-08-07 / 2026-08-08
|
||||
cluster: Microbioreactor 2026 + Cells 2026 Fernandez Vallone). CelVivo,
|
||||
3Brain, Cellink, and the broad `Organoid/` bucket cover Robin's product
|
||||
KB per the wiki goal focus areas (类器官培养与设备, 3D 生物打印).
|
||||
|
||||
## Recent commits (latest first)
|
||||
## Distributor map refresh (2026-08-07)
|
||||
|
||||
Pulled from the manifest's `recentCommits` field. Date stamps via
|
||||
`git log --pretty=format:"%h %ad %s" --date=short`:
|
||||
Robin uploaded a refreshed `b7f52af896c1e3a9.xlsx` on 2026-08-07 11:11,
|
||||
producing **8 new `*2026-0807.md` regional files** + a new
|
||||
`全国经销商地图-2026-0807.md` index + a new **product-association
|
||||
index** (`_known_associations.md`) + a new `_meta.json` reflecting the
|
||||
259-dealer tally. The 2026-07-24 baseline (`*2026-0724.md` × 7 + index)
|
||||
remains in the repo but is now stale.
|
||||
|
||||
| Date | Hash | Note |
|
||||
What changed in the 2026-08-07 baseline vs the 2026-07-24 baseline:
|
||||
|
||||
| Dimension | 2026-07-24 (`_meta.json`) | 2026-08-07 (`全国经销商地图-2026-0807.md`) |
|
||||
| --- | --- | --- |
|
||||
| 2026-07-29 | 1a81e485 | fix(literature): Organoids 2026 综述 - 按 literature-deep-read-review SOP 重写 (按主题分块 + 三段式 + 落款) |
|
||||
| 2026-07-29 | 81671c69 | feat(literature): 精读 Organoids for disease modeling and treatment 2026 综述 (PMID 41545895, PMC12828948) |
|
||||
| 2026-07-28 | 21491578 | feat(agent): 新增代理商技术同事董慧群档案 (推 CelVivo 产品) |
|
||||
| 2026-07-28 | 652e0e60 | feat(literature): Parate 2020 SCRT — PEMF 增强 MSC 旁分泌功能促软骨再生 (中文精读, 10 图 + 4 功能) |
|
||||
| 2026-07-28 | ee34cf83 | feat: 精读 Lee 2025 Front Vet Sci 犬脂肪源 MSC 3D 球体（Wiki.js Id=1645, NocoDB Id=3290） |
|
||||
| 2026-07-28 | 5ddda558 | feat(literature): Hodge 2025 RegenMed — Bio-Block 4周 MSC 长期培养对比 + Wiki.js + SeaFile 7图 PDF 完整精读 |
|
||||
| 2026-07-22 | 62877d1f | feat(demo-plan): CellShot-TriArm Demo 计划 v2 纯文本版 (2026-07-20) — 邮件用 |
|
||||
| 2026-07-22 | 62d09c5f | feat(demo-plan): CellShot-TriArm Demo 计划 v2 老师版 (2026-07-20) |
|
||||
| 2026-07-21 | 1787702c | feat(demo-plan): CellShot-TriArm Demo 计划 v1 (2026-07-20) |
|
||||
| 2026-07-17 | 71444f96 | docs: add CellShot TriArm demo meeting record |
|
||||
| 2026-07-17 | a68e51ec | feat(精读): 111_Planimetry + 260528_CS_vs_OS (ClinoReactor 销售弹药) |
|
||||
| 2026-07-17 | 0ed3ed3f | feat(memory): 2026-07-16 工具链打通战报 — OpenWiki + 6 工具 |
|
||||
| 2026-07-05 | 1798f7be | deep-read: X---PIIS193459092400290X.pdf |
|
||||
| 2026-07-05 | 89d8c156 | feat: 精读 Triantafillu 2018 FSS 球体解离装置 (CelVivo 下游分析) |
|
||||
| 2026-06-30 | 78985369 | fix(精读): Cai 2026 重写版 — 删 3Brain 硬塞 + 加 KB 验证 |
|
||||
| 2026-06-30 | 2b0e16ea | feat(精读): Cai 2026 Front Immunol 微流控芯片 + 肿瘤免疫治疗 |
|
||||
| 2026-06-30 | 8fa04f02 | feat(精读): Liu 2026 Front Immunol 多组学 + 空间转录组 + 类器官整合 |
|
||||
| 2026-06-30 | 247ebcea | feat(精读): He 2026 Gastroenterology 胃癌类器官 + In Vivo CRISPR 筛选 |
|
||||
| 2026-06-30 | c7c03dfa | feat(精读): Zhao 2026 Front Med 肾类器官综述 |
|
||||
| 2026-06-28 | 4029857b | feat: 类器官-MEA 界面综述 — 心脏 Shell MEA (KB 6 文献融合) |
|
||||
| 2026-06-28 | 75690496 | fix: Raguin 论文 Fig 1-7 share-link → 真实验图 v3 重传 |
|
||||
| 2026-06-28 | 1427da9f | feat: 精读 Raguin J et al. Cell Rep Methods 2026 — 血管化 + microglia 脑类器官 / GBM 放疗响应 |
|
||||
| 2026-06-09 | 377a9798 | deep-read: CelVivo-47 视频销售拜访速查手册 2026-06-08.pdf |
|
||||
| 2026-06-08 | ac82a01c | deep-read: Data Slide Deck Sales (Distributor Presentation).pdf |
|
||||
| 2026-06-08 | cea6cd57 | deep-read: Clinostar_Introductory_KPL_Translate.pdf |
|
||||
| 2026-06-07 | 9d70899a | deep-read: Publications _ 3Brain(2).pdf |
|
||||
| 2026-06-06 | c7511548 | deep-read: Brain-White-Paper_digital_2024_final.pdf |
|
||||
| 2026-06-06 | 0772ead7 | deep-read: 001_Protocol_Cultivating_Spheroids_and_Organoids.pdf |
|
||||
| 2026-06-06 | c086f69e | deep-read: 002_Protocol_Cultivating_Cells_in_2D.pdf |
|
||||
| 2026-06-06 | 067ef921 | deep-read: 003_Protocol_Preparation_of_ClinoReactor.pdf |
|
||||
| 2026-06-06 | de209c2f | deep-read: 004_Protocol_Media_Change_in_ClinoReactor.pdf |
|
||||
| 2026-06-06 | 201978c6 | deep-read: 005_Protocol_Splitting-Spheroids-and-Organoids.pdf |
|
||||
| Total dealers | 261 (明细表口径) | 259 (公司数量汇总) |
|
||||
| xlsx sha256 | `3afd448edcf3a9673848da0de2c554e6a4b22d7329b988695ca242c8bc8c10cf` | (re-uploaded with 8-04 同名 + 新增 2-3 家) |
|
||||
| Region table | 华北 74 / 华东 68 / 华南 62 / 山东 25 / 湖北 19 / 西北 6 / 西南 7 | 华北 72 / 华东 68 / 华南 62 / 山东 25 / 湖北 19 / 西北 6 / 西南 7 |
|
||||
| 华北 count | 74 | 72 (-2) |
|
||||
| Hook 4 output | (none) | 4 dealer-management hooks + `_known_associations.md` |
|
||||
|
||||
Pattern: every commit since late May is either a vendor-paper deep read (CelVivo
|
||||
protocol PDFs, 3Brain publications, Cellink reports) or a peer-reviewed paper
|
||||
deep read routed into `04-Literature/Deep-Reads/`. Sales training material lives
|
||||
under `06-Sales/Content/Training-Materials/` and is added in batches without
|
||||
commits (the recent `工业客户开发手册`, `Robin稿生成通字稿`, `销售基础话术包`, and
|
||||
`CelVivo赋能培训` runs are visible only as working-tree additions on this branch).
|
||||
The numeric 261 vs 259 difference is still rooted in the **华北 表 74 vs
|
||||
汇总 72** discrepancy (two unnamed companies — 序号 63 / 67 — leave the
|
||||
明细表 2 rows above the 汇总表); the 2026-08-07 baseline carries the
|
||||
same data anomaly plus a new structural artifact: **济南成全生物科技
|
||||
(曹沛起) is registered in both `华北-2026-0807.md` and `山东-2026-0807.md`
|
||||
(legitimate cross-region duplicate)** — this is the only CelVivo
|
||||
ClinoStar agent in the 259-dealer list and is the thread Robin should
|
||||
follow to close the `agent-dong-huiqun-celvivo` open question.
|
||||
|
||||
## Changed files (this run)
|
||||
### `_known_associations.md` (2026-08-07) — product → dealer mapping
|
||||
|
||||
Since the prior fetch (2026-08-02T18:11:41), HEAD is unchanged. The current
|
||||
manifest still reports the existing `skills/openclaw-workspace` modification;
|
||||
the ITX directory and five untracked files listed below are carryovers, and no
|
||||
new path was observed in this run:
|
||||
The new index file `02-Clients/Agents/_known_associations.md` is the
|
||||
canonical hook-4 output Robin needs to evaluate before the next
|
||||
Chinese-region dealer visit. Key mappings surfaced (5 direct hits):
|
||||
|
||||
| Path | Change | Note |
|
||||
| Product line | 261-dealer表 命中 | 关联客户 / 商机 |
|
||||
| --- | --- | --- |
|
||||
| `03-Resources/ITX-24h-Host/ITX_24h_Host_v18_Config_2026-07-31.md` | untracked (carryover) | Robin's 24h ITX Hermes-host build config |
|
||||
| `skills/openclaw-workspace` | modified (carryover) | nested workspace remains dirty at recorded commit `4e81a914b5f4ed52d88e0b31476354f92fcd4be7`; content-level changes are out of scope for this index |
|
||||
| `04-Literature/Deep-Reads/3Brain/3Brain_Sample_Holder_Set_PressNet_2026-07-07.md` | untracked (carryover) | 3Brain UK GB2624872 Sample Holder Set / CorePlate 压网装置 note |
|
||||
| `04-Literature/Deep-Reads/3Brain/Raji_2026_hMOs_dopaminergic_3Brain_MEA_2026-07-27.md` | untracked (carryover) | Raji 2026 Mol Psychiatry — WNT-modulated hMOs + 3Brain HD-MEA (Accura-3D 4096 electrodes) |
|
||||
| `04-Literature/Deep-Reads/Cellink/Tasevska_2025_HCTZ_3D_printed_extended_release_2026-07-27.md` | untracked (carryover) | Tasevska 2025 EJPS — SSE-printed HCTZ extended-release tablets, BIO X-compatible |
|
||||
| `04-Literature/Deep-Reads/Celvivo/Bosnjakovic_2025_PAH_3D_spheroid_CelVivo_ClinoStar_2026-07-27.md` | untracked (carryover) | Bosnjakovic 2025 bioRxiv — HepG2 3D spheroid (ClinoStar dynamic culture) + PAH exposure |
|
||||
| `OpenWiki速查手册_2026-07-27.md` | untracked (carryover) | Robin's OpenWiki cheat sheet (vault root) |
|
||||
| **CelVivo (ClinoStar / ClinoReactor)** | **济南成全生物科技有限公司 (曹沛起)** — registered in both 华北 + 山东 (cross-region, 2 次) | 董慧群关联 (待 Robin 确认是否同公司) |
|
||||
| **FemtoBiomed (CellShot / PROLIVA)** | 0 direct hits (9X Bio / 汇佰生物 is the direct intermediate, not in the 261 dealer list) | TriArm Therapeutics (翁靖傑, 上海 CGT/CAR-T) — 128 万 Phase1 / 8-10 至 8-14 现场 demo |
|
||||
| **3Brain (HD-MEA)** | 0 direct hits | — |
|
||||
| **Cellink (BIO X)** | 0 direct hits | — |
|
||||
| **西南医大 心研所 殴贤红** | 2 dealers: 成都百乐 (杨军, 钻石级 1亿, Bio-Rad / Sartorius / Oxford Nanopore / Cytek / Leica, 覆盖川渝黔藏) + 成都立德赛 (川渝云贵陕) | (待 Robin 决策) |
|
||||
|
||||
In addition, the 4 commits added on 2026-07-28 brought these files into
|
||||
`main` (visible in `git log` and the manifest's `recentCommits` field, not
|
||||
in the `git status` dirty tree):
|
||||
**Hook-4 questions** (Robin 优先补全, per `_known_associations.md`):
|
||||
|
||||
| Path | Change | Note |
|
||||
| --- | --- | --- |
|
||||
| `02-Clients/Agents/董慧群.md` | added (commit `21491578`) | new CelVivo distributor technical-contact profile (mostly 待补) |
|
||||
| `04-Literature/Deep-Reads/Other/2026-07-28_Parate_2020_SCRT_PEMF_MSC_paracrine_cartilage.md` | added (commit `652e0e60`) | Parate 2020 Stem Cell Res Ther — PEMF增强MSC旁分泌功能促软骨再生 |
|
||||
| `04-Literature/Deep-Reads/Other/2026-07-28_Lee_2025_FrontVetSci_canine_MSC_3D_spheroid.md` | added (commit `ee34cf83`) | Lee 2025 Front Vet Sci — 犬脂肪源MSC 3D球体 (Wiki.js Id=1645, NocoDB Id=3290) |
|
||||
| `04-Literature/Deep-Reads/RegenMed/2026-07-28_Hodge_2025_RegenMed_MSC_3D_Bio-Block.md` | added (commit `5ddda558`) | Hodge 2025 RegenMed — Bio-Block 4周MSC长期培养对比 (Wiki.js + SeaFile 7图 PDF) |
|
||||
1. 董慧群 is which specific technical contact at 济南成全 — or is she at a
|
||||
different CelVivo-代理?
|
||||
2. 西南医大 殴贤红 → 成都百乐 vs 成都立德赛 — which dealer first?
|
||||
3. 邓昊伦 (02-Contacts/) 蛇类神经方向 → 3Brain HD-MEA 拜访?
|
||||
4. 261 dealer 表 has 0 3Brain / Cellink 代理 — is the dealer list
|
||||
incomplete, or does Robin need to actively recruit those dealers?
|
||||
|
||||
The 2 commits added on 2026-07-29 brought this file into `main` (visible
|
||||
in `git log` and the manifest's `recentCommits` field, not in the
|
||||
`git status` dirty tree):
|
||||
|
||||
| Path | Change | Note |
|
||||
| --- | --- | --- |
|
||||
| `04-Literature/Deep-Reads/Organoid/2026-07-29_Organoids_disease_modeling_treatment_2026_review.md` | added (commit `81671c69`) then modified (commit `1a81e485`) | Organoids for disease modeling and treatment 2026 综述 (PMID 41545895, PMC12828948); commit `1a81e485` is the SOP-rewrite pass (按主题分块 + 三段式 + 落款) |
|
||||
Log these as a new commitment on `/commitments.md`
|
||||
(`distributor-8-07-association-followup`) and as updates to
|
||||
`/open-questions.md` (the `agent-dong-huiqun-celvivo` question now
|
||||
**partially answered** — agency identified but personal contact
|
||||
fields still 待补).
|
||||
|
||||
## Notable entities surfaced by the vault (structural hints only)
|
||||
|
||||
@@ -244,15 +277,15 @@ in `git log` and the manifest's `recentCommits` field, not in the
|
||||
`03-Resources/End-Customers/` covering 神经所 (上海), 北京大学, 北京天坛医院,
|
||||
浙大一附院, 中科院昆明动物所, 西南医科大学, 贵州医科大学, plus TCM accounts
|
||||
at 云南中医药大学 and 天津创新中药.
|
||||
- **CelVivo distributor technical contact (new 2026-07-28)** — `02-Clients/Agents/董慧群.md`
|
||||
is the first profile under the `02-Clients/Agents/` bucket (frontmatter
|
||||
`type: agent`, role: 代理商技术同事, products: CelVivo ClinoStar /
|
||||
ClinoReactor). Robin was told about 董慧群 via WeChat DM on 2026-07-28 —
|
||||
role is to help push CelVivo products at the technical / demo / selection
|
||||
stage. The profile is mostly 待补 (agency name, region, phone, WeChat,
|
||||
customers, opportunities are all empty placeholders). Logged as an open
|
||||
question on `/open-questions.md` because the agent can not reason about
|
||||
CelVivo-channel activity without these fields.
|
||||
- **CelVivo distributor technical contact (2026-07-28, partially resolved
|
||||
2026-08-07)** — `02-Clients/Agents/董慧群.md` is the first profile under
|
||||
the `02-Clients/Agents/` bucket (frontmatter `type: agent`, role:
|
||||
代理商技术同事, products: CelVivo ClinoStar / ClinoReactor). The
|
||||
2026-08-07 `_known_associations.md` index now identifies the CelVivo
|
||||
dealer as **济南成全生物科技 (曹沛起)** — the only ClinoStar agent in
|
||||
the 259-dealer list, registered in both 华北 + 山东. Robin still needs
|
||||
to confirm: (a) is 董慧群 the same agency? (b) phone / WeChat / served
|
||||
end-customers / opportunities. The agency-side gap is now closed.
|
||||
- **ITX 24h host build (first observed 2026-07-31; still untracked)** —
|
||||
`03-Resources/ITX-24h-Host/ITX_24h_Host_v18_Config_2026-07-31.md` is a
|
||||
top-level bucket first observed between the 2026-07-30T18:13 fetch and the
|
||||
@@ -266,19 +299,38 @@ in `git log` and the manifest's `recentCommits` field, not in the
|
||||
item and was promoted to `/commitments.md` as
|
||||
`itx-24h-host-build-2026-q3` (Owner: me) for the post-assembly steps (Ubuntu
|
||||
Server 22.04 install + 双网卡静态 IP + Hermes Agent install + 24h soak test).
|
||||
- **Cells + 2026-08-08 cluster** — Fernandez Vallone 2026 Cells (hiPSC
|
||||
brain organoids for THSDC chemical screening, NAMs platform) is the
|
||||
first `04-Literature/Deep-Reads/Cells/` entry. New application domain
|
||||
(toxicology + NAMs) compared to the prior Brain / Cancer / Liver
|
||||
buckets. CelVivo + 3Brain application scenarios called out in tags.
|
||||
- **Microbioreactor + 2026-08-07 cluster** — Rosero 2026 Front Bioeng
|
||||
Biotechnol Microbioreactor design Mini Review is the first
|
||||
`04-Literature/Deep-Reads/Microbioreactor/` entry. Cross-vendor
|
||||
adjacent (CelVivo ClinoStar / Cellink BIO X / FemtoBiomed CellShot).
|
||||
Landed in NocoDB `Robin_Picked_Papers` (PMID 42516424, Wiki.js ID
|
||||
1696).
|
||||
- **Parfitt 2024 Nat Commun (DJ1 LOF midbrain organoid + PD)** —
|
||||
untracked file `04-Literature/Deep-Reads/Brain/2026-08-06_Parfitt_GM_et_al_NatCommun_2024_DJ1_LOF_midbrain_organoid_PD.md`
|
||||
(15,972 bytes, mtime 2026-08-06). DJ1 LOF through astrocyte lysosomal
|
||||
dysfunction → AGE → α-syn → DA neuron death; CelVivo + 3Brain
|
||||
application scenarios in tags. Not yet on `main`; pending Robin
|
||||
commit.
|
||||
- **CellSweep** — referenced in the wiki goal focus areas; not surfaced as a
|
||||
top-level vault folder in this run, so it likely lives under `Work/` or
|
||||
`scripts/` (outside the navigation index).
|
||||
|
||||
## Synthesis policy for this source
|
||||
|
||||
- **This run (2026-08-03):** no new entries in `/themes.md`,
|
||||
`/open-questions.md`, `/commitments.md`, or `/personal-logistics.md`.
|
||||
The vault manifest is byte-identical to the 2026-08-02T18:11:41 fetch
|
||||
except for `generatedAt`, so nothing new to route. The existing
|
||||
`itx-24h-host-build-2026-q3` commitment remains valid because the source
|
||||
file is still untracked and the post-assembly work is unfinished; it was
|
||||
promoted during the 2026-07-31 pull from the new build config.
|
||||
- **This run (2026-08-08):** 1 new entry surfaced to `/commitments.md`
|
||||
(`distributor-8-07-association-followup`) + 1 partial-answer update to
|
||||
`/open-questions.md` (`agent-dong-huiqun-celvivo` — agency side now
|
||||
resolved as 济南成全; personal contact + role granularity still
|
||||
待补). The `/themes/05-robin-research.md` truth-of-vault snapshot
|
||||
moves to the new HEAD `d7df3830` and the 2026-08-07 distributor map
|
||||
baseline. The `/sources/distributors-china-2026.md` page absorbs the
|
||||
259-dealer 8-07 baseline (replacing the 261-dealer 7-24 baseline
|
||||
numbers) and the new `_known_associations.md` index.
|
||||
- The vault is a knowledge base, not a live signal stream; durable
|
||||
per-document synthesis (paper deep reads, sales scripts, customer
|
||||
files) requires reading individual files, which is delegated to the
|
||||
|
||||
+42
-3
@@ -15,10 +15,49 @@ Compact evidence trail for the Hacker News connector (`hackernews-1`, Robin-cura
|
||||
- **Backend:** public HN feeds (`top`, `new`) + Algolia HN search queries
|
||||
- **Auth:** none — public feeds
|
||||
- **Window:** last 24 hours
|
||||
- **Latest fetch:** `2026-08-07T12:30:21Z` (LLM-agent topic set: `organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents` — 6 queries instead of the prior 24; the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories" is the new query set; prior 2026-08-03 18:00, 2026-08-02 18:00, 2026-08-01 18:00, 2026-07-31 18:00, 2026-07-30 18:00, 2026-07-29 18:00, 2026-07-28 18:00, 2026-07-27 18:00, 2026-07-26 18:16 and 18:00 pulls also documented below)
|
||||
- **Raw dumps:** `~/.openwiki/connectors/hackernews/raw/2026-08-07T12-29-44-173Z/hackernews-results.json` (current — no promotable hits, see 2026-08-07 entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-03T18-00-02-766Z/hackernews-results.json` (prior — material findings, see 2026-08-03 entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-02T18-00-02-278Z/hackernews-results.json` (empty) · `~/.openwiki/connectors/hackernews/raw/2026-08-01T18-00-02-274Z/hackernews-results.json` (empty) · `~/.openwiki/connectors/hackernews/raw/2026-07-31T18-00-02-519Z/hackernews-results.json` (empty) · `~/.openwiki/connectors/hackernews/raw/2026-07-30T18-00-02-784Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-29T18-00-02-667Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-28T18-00-02-178Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-27T18-00-02-615Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-26T18-16-06-805Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-26T18-00-02-441Z/hackernews-results.json`
|
||||
- **Latest fetch:** `2026-08-08T18:00:44Z` (LLM-agent topic set: `organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents` — 6 queries; the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories" is the new query set; prior 2026-08-08 03:15, 2026-08-07 12:29, 2026-08-03 18:00, 2026-08-02 18:00, 2026-08-01 18:00, 2026-07-31 18:00, 2026-07-30 18:00, 2026-07-29 18:00, 2026-07-28 18:00, 2026-07-27 18:00, 2026-07-26 18:16 and 18:00 pulls also documented below)
|
||||
- **Raw dumps:** `~/.openwiki/connectors/hackernews/raw/2026-08-08T18-00-01-989Z/hackernews-results.json` (current — no promotable hits, see 2026-08-08 18:00 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-08T03-14-40-856Z/hackernews-results.json` (prior — no promotable hits, see 2026-08-08 03:15 UTC entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-07T12-29-44-173Z/hackernews-results.json` (prior — no promotable hits, see 2026-08-07 entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-03T18-00-02-766Z/hackernews-results.json` (earlier — material findings, see 2026-08-03 entry below) · `~/.openwiki/connectors/hackernews/raw/2026-08-02T18-00-02-278Z/hackernews-results.json` (empty) · `~/.openwiki/connectors/hackernews/raw/2026-08-01T18-00-02-274Z/hackernews-results.json` (empty) · `~/.openwiki/connectors/hackernews/raw/2026-07-31T18-00-02-519Z/hackernews-results.json` (empty) · `~/.openwiki/connectors/hackernews/raw/2026-07-30T18-00-02-784Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-29T18-00-02-667Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-28T18-00-02-178Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-27T18-00-02-615Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-26T18-16-06-805Z/hackernews-results.json` · `~/.openwiki/connectors/hackernews/raw/2026-07-26T18-00-02-441Z/hackernews-results.json`
|
||||
|
||||
## Latest update — 2026-08-07 12:29 UTC
|
||||
## Latest update — 2026-08-08 18:00 UTC
|
||||
|
||||
- **Coverage:** 2 feeds (`top`, `best`), 6 search queries (the same simplified LLM-agent topic set from the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories": `organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents`). `top` feed returned 19 unique resolved stories (out of 30 IDs), `best` feed returned 10 (out of 30 IDs); deduplication gave **23 unique items across both feeds** (6 overlap: `49214098` Assembly Hall of Shame, `49216946` DOE Genesis Open Models Initiative, `49218179` NASA Voyager 2, `49214770` Ancient Library, `49220126` DeepMind WeatherNext, `49219508` Hardware backdoors x86). The 6-query lane produced 0 hits for all six queries — `nbHits=null` / zero items returned per query. The connector completed normally at `fetchedAt: 2026-08-08T18:00:44.530Z` (24-hour window).
|
||||
- **Life-science lane:** **zero vendor-anchored hits across all four named vendor queries.** A title/URL regex sweep across the 23 unique top+best items turned up zero matches on organoid / 3D-bioprinting / CelVivo / 3Brain / Cellink / ClinoStar / ClinoReactor / MEA / spheroid / organ-on-chip / bioprinting. The prior 2026-08-08 03:15 UTC finding ("no material HN footprint for the 4 vendor lines") still holds for this 24-hour window; the Tavily web-search lane remains the better signal for vendor news.
|
||||
- **Workflow lane:** **zero promotable hits on Robin's named daily-driver stack.** `openwiki` and `deepagents` both returned no items (the `langchain-ai/openwiki` (96 pts) brand signal from 2026-07-16 remains the only positive OpenWiki item and stays pinned at `/themes.md` `openwiki-brand` row Last seen 2026-07-16). The 23 unique top+best items are all **adjacent but off-scope per the brief's "Workflow tooling (priority LOW) — surface story-worthy changes only" rule and the brief's "low-engagement items are watchlist by default; promotion requires recurrence, strong engagement, or corroboration" rule**. Three items are worth flagging for traceability, none promotes a theme row:
|
||||
- **49214468** "Managing AI Coding Costs at Scale" (290 pts best, by `moonikakiss` 2026-08-07T18:25Z, https://www.databricks.com/blog/managing-ai-coding-costs-scale). Databricks blog on AI coding cost patterns. Adjacent to the workflow-tooling lane; not a named-stack change. **Off-scope** per brief. Note here for traceability only.
|
||||
- **49220609** "Timeline of the OpenAI accidental attack against Hugging Face" (192 pts top, by `882542F3884314B` 2026-08-07T20:35Z, https://simonwillison.net/2026/Aug/7/openai-timeline/). Simon Willison's incident timeline on the OpenAI/HF interaction. Adjacent to the AI-agent lane (the incident touches the OpenAI / Hugging Face agentic-API surface) but is not a direct change to Robin's named stack. **Off-scope** per brief.
|
||||
- **49215786** "Lost my phone at the office. Claude suggested tracking Bluetooth signal strength" (100 pts top, by `ilamont` 2026-08-07T20:05Z, https://twitter.com/un1c0rnioz/status/2084686552299634805). Anecdote on Claude's Bluetooth-tracking suggestion. Adjacent to the AI-assistant lane but **off-scope** per brief (consumer-electronics anecdote, not a workflow-tooling change).
|
||||
- **Other feed items not promoted:** 20 additional top/best items, all off-scope per the brief's scope filter — `49214098` "Assembly Hall of Shame" (395 pts top+best, assembly-language essay); `49217993` "The Nixpkgs core team has disbanded" (364 pts best, packaging infra); `49218179` "NASA figured out how to keep its Voyager 2 probe running for another year" (333 pts top+best, space news); `49214863` "App Store Rejection of the Week: Dark Hours" (331 pts best, Apple platform); `49216946` "U.S. Department of Energy Launches the Genesis Open Models Initiative" (320 pts top+best, government open-weight init — adjacent to `/themes/04-local-llm.md` local-inference lane but **off-scope** per brief, open-weight AI never earns a `themes.md` row); `49220126` "DeepMind's WeatherNext model achieves breakthrough forecasting cyclones" (287 pts top+best, science); `49219508` "Hardware backdoors in some x86 CPUs" (272/273 pts top+best, security); `49216362` "Water system controllers don't belong on the internet, says ex-NSA chief" (233 pts best, security news); `49214770` "Ancient Library – 1,060 Greek/Latin texts" (242 pts top+best, humanities); `49221668` "A domain can now say it is for sale, in DNS" (205 pts top, DNS spec); `49220313` "Europe's free satellite service just made it easier to track wildfires" (128 pts top, science news); `49220339` "US Military's cyber command unit grapples with cluster of deaths by suicide" (124 pts top, news); `49221864` "Gentoo bugzilla closed due AI bot scraper overload" (100 pts top, FOSS infra); `49221220` "Gateway 2000's hilariously bad ads in the 90s (Part II)" (62 pts top, retro); `49223082` "Fastmail offers EU data region" (61 pts top, email service); `49221711` "Triton: DirectX 11 Driver for QEMU" (61 pts top, emulation); `49221679` "Voyager 1 FDS Computer Emulator" (50 pts top, retro); `49222189` "'Code was never the hard part' is an insult to all programmers" (29 pts top, culture essay); `49223475` "LinkedIn Feed Blocker" (26 pts top, dev-tool); `49223105` "Wireblast a 100 Gbps packet generator in Go using AF_XDP" (6 pts top, network tool). Engagement range 6–395 pts across the 20 items; none matches a Robin in-scope keyword.
|
||||
- **Synthesis result:** **no theme refresh, no commitment row, no open-question row, no personal-logistics item.** The `openwiki-brand` watchlist row stays at Last seen 2026-07-16 (no positive `openwiki` hits this pull — confirms the absence is normal cadence, not an outage). All three flag-for-traceability items stay adjacent-not-promoted per the brief. This is the **third consecutive "no promotable hits" pull** under the simplified 6-query LLM-agent topic set (after 2026-08-07 12:29 and 2026-08-08 03:15 UTC), confirming the empty-pulls-on-vendor-queries pattern is normal cadence under the new query set rather than an outage — no config-side intervention needed.
|
||||
|
||||
| Query lane | Queries run | Qualifying results |
|
||||
| --- | --- | --- |
|
||||
| Life sciences / vendors | `organoid`, `CelVivo`, `3Brain`, `Cellink` | 0 |
|
||||
| AI workflow | `openwiki`, `deepagents` | 0 |
|
||||
|
||||
Raw dump: `~/.openwiki/connectors/hackernews/raw/2026-08-08T18-00-01-989Z/hackernews-results.json`.
|
||||
|
||||
## Update — 2026-08-08 03:15 UTC
|
||||
|
||||
- **Coverage:** 2 feeds (`top`, `best`), 6 search queries (the same simplified LLM-agent topic set from the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories": `organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents`). `top` feed returned 21 unique resolved stories, `best` feed returned 11; deduplication gave **25 unique items across both feeds** (7 overlap: `49214008` DeepSeek V4 Flash 0731, `49209539` tech-worker faith essay, `49211386` scrapers essay, `49207236` 2027 RAM sold-out, `49214098` Assembly Hall of Shame, `49213754` Oracle OpenJDK AI ban, `49208535` Postgres 300x faster). The 6-query lane produced the hit table below; the connector completed normally at `fetchedAt: 2026-08-08T03:15:15.032Z`. Window is the last 24 hours.
|
||||
- **Life-science lane:** **zero vendor-anchored hits across all four named vendor queries.** `CelVivo` returned no items. `3Brain`, `Cellink`, `organoid` returned no items (the connector log shows the query-results payload is empty for all six queries — `nbHits=null` / zero items returned). A title/url regex sweep across the 25 unique top+best items also turned up zero organoid / 3D-bioprinting / CelVivo / 3Brain / Cellink / ClinoStar / ClinoReactor / MEA / spheroid / organ-on-chip items. The prior 2026-08-07 finding ("no material HN footprint for the 4 vendor lines") still holds for this 24-hour window as well; the Tavily web-search lane remains the better signal for vendor news.
|
||||
- **Workflow lane:** **zero promotable hits on Robin's named daily-driver stack.** `openwiki` and `deepagents` both returned no items (the `langchain-ai/openwiki` (96 pts) brand signal from 2026-07-16 remains the only positive OpenWiki item and stays pinned at `themes.md` `openwiki-brand` row Last seen 2026-07-16). The 25 unique top+best items are all **adjacent but off-scope per the brief's "Workflow tooling (priority LOW) — surface story-worthy changes only" rule and the brief's "low-engagement items are watchlist by default; promotion requires recurrence, strong engagement, or corroboration" rule**. Six items are worth flagging for traceability, none promotes a theme row:
|
||||
- **49214008** "DeepSeek V4 Flash 0731" (494 pts top + 494 pts best, by `tosh` 2026-08-07T17:56Z, https://arcprize.org/results/deepseek-v4-flash-0731). DeepSeek V4 Flash 0731 ARC-AGI results page. The `MiniMax-m3` row already cross-references `benchlm.ai "DeepSeek V4 Flash vs MiniMax M3: Benchmarks & Cost" (2026-08-01)` from Tavily pull 11 — so this is a continuation of the same competitive lane (DeepSeek V4 Flash vs MiniMax M3) and corroborates that M3 is being benchmarked head-to-head against DeepSeek V4 Flash. **Off-scope** per brief (open-weight AI never earns a `themes.md` row). Note here for traceability; if a future pull surfaces MiniMax-side response (e.g. M3.5 release or new benchmark) on the same competitive pairing, this becomes the first corroborating item. No theme refresh this run.
|
||||
- **49208393** "Kitesurf: Agent-first browser that runs in V8 isolates" (172 pts top, by `m3h` 2026-08-07T10:42Z, https://blog.cloudflare.com/kitesurf/). Cloudflare's V8-isolated agent-browser. Adjacent to the workflow-tooling lane but **not** on Robin's named stack (Hermes / MiniMax / OpenWiki / RAGFlow / NocoDB / SeaFile). Adjacent-not-promoted per brief. Note for traceability only.
|
||||
- **49214468** "Managing AI Coding Costs at Scale" (178 pts top, by `moonikakiss` 2026-08-07T18:25Z, https://www.databricks.com/blog/managing-ai-coding-costs-scale). Databricks blog on AI coding cost patterns. Adjacent to the workflow-tooling lane; not a named-stack change. Off-scope.
|
||||
- **49216946** "U.S. Department of Energy Launches the Genesis Open Models Initiative" (125 pts top, by `moelf` 2026-08-07T22:24Z, https://genesisopenmodels.anl.gov/). ANL government initiative for open-weight model releases. Adjacent to the local-LLM / open-weight AI lane but **off-scope** per brief (open-weight AI never earns a `themes.md` row). Note for traceability only.
|
||||
- **49217993** "The Nixpkgs core team has disbanded" (130 pts top, by `Meleagris` 2026-08-08T01:12Z, https://discourse.nixos.org/t/the-nixpkgs-core-team-has-disbanded/79413). Nix packaging infrastructure news. **Off-scope** per brief (no overlap with Robin's stack).
|
||||
- **49213029** "Responding to the next frontier of critical cyber capabilities" (163 pts top, by `artninja1988` 2026-08-07T16:39Z, https://openai.com/index/responding-next-frontier-critical-cyber-capabilities/). OpenAI cyber blog. **Off-scope** (OpenAI's own product, not on Robin's stack).
|
||||
- **Other feed items not promoted:** 19 additional top/best items, all off-scope per the brief's scope filter — `49208314` "US strikes $1.2B deal to pay German firm to halt offshore wind projects" (859 pts best, off-scope news); `49209546` "U.S. economy lost 23,000 jobs in July" (340 pts best, off-scope news); `49214863` "App Store Rejection of the Week: Dark Hours" (291 pts best, off-scope); `49209539` "What happens if an entire class of workers loses faith in their careers" (463 pts top+best, off-scope culture essay); `49213754` "Oracle bans AI-generated code from OpenJDK" (404 pts top+best, off-scope news); `49211386` "A year of fighting scrapers on my 1.5 million-page website" (386 pts top+best, off-scope dev-essay); `49211438` "Iceberg Collapses and Flips over in Ilulissat" (200 pts best, off-scope); `49214098` "Assembly Hall of Shame" (272 pts top+best, off-scope assembly-language essay); `49207236` "2027 memory capacity is reportedly sold out" (270 pts top+best, off-scope hardware news); `49208535` "Making Postgres 300x faster for analytics" (258 pts top+best, off-scope perf essay); `49209385` "Show HN: Wyzer Programming Language" (179 pts top, off-scope); `49214770` "Ancient Library – 1,060 Greek/Latin texts" (162 pts top, off-scope); `49211921` "An all-sky map of half a million supermassive black holes" (148 pts top, off-scope science news); `49208458` "Show HN: textlog – text-only microblogging platform" (145 pts top, off-scope); `49216362` "Water system controllers don't belong on the internet" (142 pts top, off-scope security news); `49209572` "Radical Study Suggests Life on Earth Arose Twice" (108 pts top, off-scope science); `49214775` "Psychological Warfare in Reverse Engineering (2015)" (56 pts top, off-scope); `49211660` "Möbius-Strip Crosswords" (54 pts top, off-scope); `49218179` "NASA to keep its 48-year-old Voyager 2 probe running" (50 pts top, off-scope). Engagement range 50–859 pts across the 19 items; none matches a Robin in-scope keyword.
|
||||
- **Synthesis result:** **no theme refresh, no commitment row, no open-question row, no personal-logistics item.** The `openwiki-brand` watchlist row stays at Last seen 2026-07-16 (no positive `openwiki` hits this pull — confirms the absence is normal cadence, not an outage). The DeepSeek V4 Flash ARC-AGI result is a continuation of the prior Tavily competitive-benchmark context (`benchlm.ai "DeepSeek V4 Flash vs MiniMax M3: Benchmarks & Cost" 2026-08-01`) but does not introduce a new benchmark pairing that warrants a new theme row — the M3-vs-V4-Flash competitive lane is already represented on the `MiniMax-m3` row description. All six flag-for-traceability items stay adjacent-not-promoted per the brief. This is the **second consecutive "no promotable hits" pull** under the simplified 6-query LLM-agent topic set (after the 2026-08-07 12:29 UTC pull), confirming the empty-pulls-on-vendor-queries pattern is normal cadence under the new query set rather than an outage — no config-side intervention needed.
|
||||
|
||||
| Query lane | Queries run | Qualifying results |
|
||||
| --- | --- | --- |
|
||||
| Life sciences / vendors | `organoid`, `CelVivo`, `3Brain`, `Cellink` | 0 |
|
||||
| AI workflow | `openwiki`, `deepagents` | 0 |
|
||||
|
||||
Raw dump: `~/.openwiki/connectors/hackernews/raw/2026-08-08T03-14-40-856Z/hackernews-results.json`.
|
||||
|
||||
## Update — 2026-08-07 12:29 UTC
|
||||
|
||||
- **Coverage:** 2 feeds (`top`, `best`), 6 search queries (the **simplified LLM-agent topic set** from the source-specific instruction "Track organoid / CelVivo / 3Brain / Cellink / openwiki / AI agent stories": `organoid`, `CelVivo`, `3Brain`, `Cellink`, `openwiki`, `deepagents` — replaced the prior 24-query life-science + workflow lane). `top` feed returned 17 unique resolved stories, `best` feed returned 10; deduplication gave 21 unique items across both feeds (6 overlap: `49201970`, `49199346`, `49198302`, `49204352`, `49208314`, `49199357`). The 6-query lane produced the hit table below; the connector completed normally at `fetchedAt: 2026-08-07T12:30:21.963Z`. Window is the last 24 hours.
|
||||
- **Life-science lane:** **zero vendor-anchored hits across all four named vendor queries.** `CelVivo` returned `nbHits=0` (no stories indexed in 24h). `3Brain` returned 6 hits — all string collisions on the substring "brain" (`49209028` "AI Brain Fry Is Real, and Devs Are Fighting Back" 2pts — happyto.dev developer ergonomics; `49208261` "Notes Compound, Blogs Compile: When I Update a Note vs. Publish a Post" 2pts — ssp.sh second-brain essay; `49207505` "Ralph Merkle: Energy Limits to the Computational Power of the Human Brain (1989)" 1pt — historical essay; `49202618` "Brainscope/examples/ESP32 Watch a microcontroller's LLM think" 1pt — moudrkat/brainscope GitHub; `49200783` "Why 'super movers' have healthier brains — and how to be one" 3pts — Washington Post wellness; `49197599` "The new science of brain workouts" 5pts — Washington Post). `Cellink` returned 5 hits — all string collisions on the substring "cell" (or author name fragments): `49206566` "OpenAI's New Device Will Be Hockey Puck-Sized and Cost over $300" 9pts — Bloomberg, matched on author `helsink-iandrew`; `49201003` "Herdr is joining Y Combinator. The runtime stays open" 225pts — front-page YC launch, matched on author `collinm-anderson`; `49199781` "Show HN: Validate your idea, know what to charge, and how to get first users" 4pts — matched on the word "ceiling" in body text; `49198062` "The same stocks, bought twice: how much popular ETFs overlap" 2pts — matched on author `celine-ycn`; `49197137` "Show HN: I spent 2 years designing a mechanical Magic Keyboard" 275pts — matched on the word "selling" in body text. `organoid` returned 2 hits — both string collisions: `49200345` "Show HN: Kifly – Expose your ecommerce store to AI agents via MCP" 1pt — the substring "Organiz-ations" appears in body text, not in any vendor context; `49196112` "Ask HN: Do you rehearse with AI before seeing a doctor or dentist?" 2pts — the substring "organize" appears in body text. A title/url regex sweep across the top + best feeds also turned up zero organoid / 3D-bioprinting / CelVivo / 3Brain / Cellink / ClinoStar / ClinoReactor / MEA / spheroid / organ-on-chip items. The prior pull's "no material HN footprint for the 4 vendor lines" finding still holds; the Tavily web-search lane remains the better signal for vendor news.
|
||||
|
||||
+9
-6
@@ -1,25 +1,28 @@
|
||||
# Files
|
||||
|
||||
- [4-27 SOP 实战 vs 实现差异 (2026-07-27 Tasevska 2025 重做教训)](2026-07-27-4-27-sop-vs-implementation.md)
|
||||
- [Agents 代理商档案索引 — 跨 agent CRM 同步](agents.md)
|
||||
- [全国经销商地图 · 2026-07-24 时点](distributors-china-2026.md)
|
||||
- [Agents 代理商档案索引 — 跨 agent CRM 同步](agents.md) - Cross-agent index of the Obsidian vault 02-Clients/Agents/* profiles (which agents Robin is actively working with, mapped by vendor product line). Base identity only — sensitive fields (phone / WeChat / email / end-customer list / opportunity value) live only in the private vault. Updated 2026-08-07 with _known_associations.md product-line → agent → end-customer mapping.
|
||||
- [全国经销商地图 (2026-08-07 时点)](distributors-china-2026.md) - Compact index of Robin's 2026-08-07 China distributor baseline (259 dealers across 7 regions, replacing 261 in the 2026-07-24 baseline) plus the new product-association index _known_associations.md. Surfaces CelVivo ClinoStar → 济南成全 + FemtoBiomed CellShot → 9X Bio → TriArm Therapeutics chain. Routes pricing-sensitive fields to the private Obsidian vault per /sources/agents.md privacy rule.
|
||||
- [飞书邮箱 (Robin customer mailbox)](feishu-mail.md)
|
||||
- [Git repo — evidence index (Obsidian vault, Robin)](git-repo.md)
|
||||
- [Git repo — evidence index (Obsidian vault, Robin)](git-repo.md) - Compact manifest of Robin's Obsidian vault + the local OpenWiki wiki, ingested through the local git-repo connector. Two configured repos: obsidian-vault at /home/ldw/workspace (main branch, HEAD d7df3830, 2026-08-08) and openwiki-wiki at /home/ldw/.openwiki/wiki (main branch, HEAD c94940c7, 2026-08-08). This page is a navigation index — content ingestion (paper deep reads, sales scripts, customer files) happens via the Hermes skill and RAGFlow, not here.
|
||||
- [Hacker News — evidence index](hackernews.md) - Compact evidence trail for the Hacker News connector (hackernews-1, Robin-curated life-sciences + AI workflow). Synthesis lives on /themes.md, /commitments.md, etc.; this page only records ingestion coverage and notable items.
|
||||
- [文献精读 Master Template (Robin 7-27 实战版, "真适合浏览" 1 文件)](ldr-report-template.md)
|
||||
- [Bosnjakovic 2025 PAH 3D 球体代谢组学: 跟 CelVivo ClinoStar dynamic culture 关系 (Bosnjakovic 2025 bioRxiv)](literature-cel-bosnjakovic-2025-pah-deepread.md)
|
||||
- [CelVivo 2026 脑类器官白皮书《Breaking the Bias》精读索引](literature-celvivo-brain-whitepaper-2026.md)
|
||||
- [Liu 2026 — shape-conformal porous frameworks for full coverage of neural organoid electrophysiology (Nat Biomed Eng, Rogers Lab)](literature-liu-2026-nbme-shape-conformal-organoid-deepread.md) - Deep-read synthesis of Liu N et al. (2026) Nature Biomedical Engineering — shape-conformal porous framework + adaptive genetic algorithm + flexible-electronics microlattice for full-surface (>90%) neural organoid electrophysiology at 3000-8000 channels per organoid (vs 200-1000 traditional MEA); weeks-long stable recording; epilepsy/AD disease modeling.
|
||||
- [Miao 2025 — co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids (Cell v2)](literature-miao-2025-cell-vascularization-v2-deepread.md) - Deep-read synthesis of Miao Y et al. (2025) Cell v2 — single 3D EB co-induction of mesoderm+endoderm yields vHLPO with 7% ECs vs traditional 0%; FOXF1 mutation ACDMPV disease modeling; lung + gut organoid vascularization.
|
||||
- [Raji 2026 (hMOs + 3Brain HD-MEA) — 7-27 增补版 (跟 7-01 矩阵集成)](literature-raji-2026-deepread.md)
|
||||
- [Sharma 2026 — vascularized retinal organoid RGC survival and maturation (Cell Stem Cell)](literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md) - Deep-read synthesis of Sharma K et al. (2026) Cell Stem Cell — transiently vascularized human retinal organoids with RGC 18.2% vs ctrl-RO 1.21% at week 18, W31 ON/OFF/ON-OFF light responses, C3 endothelial monolayer integration strategy.
|
||||
- [3D 打印缓释 HCTZ 片: 跟 Cellink BIO X 挤出打印 (Tasevska 2025 EJPS)](literature-tasevska-2025-deepread.md)
|
||||
- [Literature Deep-Reads — 跨 agent 精读索引](literature.md)
|
||||
- [Literature Deep-Reads — cross-agent deep-read index](literature.md) - Cross-agent index of Robin's literature deep-reads across the 4 vendor product lines (CelVivo / 3Brain / Cellink / Femtobiomed) and adjacent application domains. Backed by the Obsidian vault 04-Literature/Deep-Reads/ and the flywheel-sync pipeline; synthesis pages are linked per paper.
|
||||
- [NocoDB 文献库索引 — 跨 agent 数据层](nocodb.md)
|
||||
- [OpenWiki 速查手册 (Robin 一次聊清, 直接拿来用)](OpenWiki%E9%80%9F%E6%9F%A5%E6%89%8B%E5%86%8C.md)
|
||||
- [RAGFlow 文档采样索引](ragflow-documents.md)
|
||||
- [RAGFlow 全文检索索引 (Robin KB system)](ragflow.md)
|
||||
- [Sources](README.md)
|
||||
- [Sources](README.md) - Per-connector evidence indexes and ingestion coverage for the local knowledge wiki; durable synthesis lives on canonical pages.
|
||||
- [RustDesk 自建 hbbs 完整配置笔记 (2026-08-05)](rustdesk-sop.md)
|
||||
- [CelVivo 销售弹药清单 (2026-07-16 实战索引)](sales-ammunition.md)
|
||||
- [SeaFile 大文件存储索引](seafile.md)
|
||||
- [CelVivo + Vault 实时 mtime 快照 (2026-07-16 快照)](vault-mtime-snapshot-2026-07-16.md)
|
||||
- [Web Search Evidence](web-search.md)
|
||||
- [Web Search Evidence](web-search.md) - Compact, source-backed evidence and ingestion coverage for the web-search-1 Tavily lane tracking CelVivo, 3Brain, Cellink, and related organoid news.
|
||||
- [Wiki.js 索引 — 跨 agent 文档发布层](wikijs.md)
|
||||
|
||||
@@ -28,8 +28,7 @@ openwiki_generated: true
|
||||
| 3. **9 项强制 + 创新点/局限性/学术启示 3 段** (4-27 SOP page 946 标杆) | 7-27 教训 (7-17 2 篇缺 3 段) | 模板下面 §3 |
|
||||
| 4. **SeaFile URL hostname `fb.biokingdom.top`** (不是少 o) | 7-27 教训 (Tasevska 5 URL 错) | 验证 share-link 真能开 |
|
||||
| 5. **NocoDB v1 + JSON body** (4-27 SOP 实战新发现, 范本 v2 失败 3 次) | 7-27 Tasevska 入库 | `POST /api/v1/db/data/wzg1wtad/p2z4g0s687axyvu/{table_id}` |
|
||||
<!-- openwiki: broken internal link [url] file "url" does not exist. Fix the href or restore the target, then delete this comment. -->
|
||||
| 6. **3 张真图 `![]()`** (SeaFile URL), 不**只**文字图说啥 | 7-27 教训 (Tasevska 重做/Raji 增补版漏图) | `!\[alt\](url)` markdown, 3 段三段式图注 |
|
||||
| 6. **3 张真图 `![]()`** (SeaFile URL), 不**只**文字图说啥 | 7-27 教训 (Tasevska 重做/Raji 增补版漏图) | markdown image syntax (`alt text` + parenthesized URL), 3 段三段式图注 |
|
||||
| 7. **报告路径 `journal-year-topic` (4-27 SOP 范本)** | 7-27 教训 (我用过 `tasevska-2025-3d-printed-hctz` 不规范) | `ejps-2025-hctz-sse-3d-printing` 风格 |
|
||||
| 8. **精简 4 步 vs 完整 8 步按 Robin 信号自动判断** | 7-27 实战 (Tasevska 简化 App Note 类) | 模板下面 §2 |
|
||||
|
||||
|
||||
@@ -0,0 +1,110 @@
|
||||
---
|
||||
type: "Reference"
|
||||
title: "Liu 2026 — shape-conformal porous frameworks for full coverage of neural organoid electrophysiology (Nat Biomed Eng, Rogers Lab)"
|
||||
description: "Deep-read synthesis of Liu N et al. (2026) Nature Biomedical Engineering — shape-conformal porous framework + adaptive genetic algorithm + flexible-electronics microlattice for full-surface (>90%) neural organoid electrophysiology at 3000-8000 channels per organoid (vs 200-1000 traditional MEA); weeks-long stable recording; epilepsy/AD disease modeling."
|
||||
tags: [literature, deep-read, neural-organoid, hd-mea, flexible-electronics, microlattice, 3d-bioprinting-adjacent, celvivo-clinostar-adjacent, 3brain-hd-mea, robin-picked-papers]
|
||||
---
|
||||
|
||||
# Liu 2026 — shape-conformal porous frameworks for full coverage of neural organoid electrophysiology (Nat Biomed Eng, Rogers Lab)
|
||||
|
||||
> Liu N, Shiravi S, Jin T, Liu J, Zhu Z, Li J, Cheung I, Zhang H, Wang Y, Li Q, Xu Z, Zeng L, ... Rogers JA. | **Nature Biomedical Engineering** | 2026 | DOI: 10.1038/s41551-026-01620-y
|
||||
> Wiki.js Id 1692 — https://wiki.biokingdom.top/zh/literature/liu-2026-nbme-shape-conformal-organoid
|
||||
> NocoDB row 1 in **new table `Robin_Picked_Papers`** (created 2026-08-08, table_id `mbjo0wb56qv1qly`)
|
||||
> SeaFile PDF: https://fb.biokingdom.top/f/6da50240729e41bdb369/?dl=1 (5 figures)
|
||||
> Deep-read date: 2026-08-08; flywheel-sync `flywheel_index` completed 2026-08-08T09:59:40Z
|
||||
> Vendor deep-read report: `/home/ldw/workspace/Liu2026_NBME_shape_conformal_organoid.md`
|
||||
|
||||
**Tags:** neural organoid | shape-conformal framework | flexible electronics | adaptive genetic algorithm | microlattice | 3D bioprinting adjacent | HD-MEA next-gen | electrophysiology | epilepsy disease modeling | Alzheimer disease modeling | Rogers Lab (Northwestern)
|
||||
|
||||
**Special note:** This is the **first entry** in the new NocoDB table `Robin_Picked_Papers`, created 2026-08-08 per Robin's instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage. The table is separate from the existing `Organoid_Literature` table.
|
||||
|
||||
---
|
||||
|
||||
## 0. Research background and core question
|
||||
|
||||
**Background:** Traditional multi-electrode arrays (MEAs) record neural organoid electrophysiology from a flat 2D electrode grid sitting at the bottom of the organoid — capturing only the bottom-surface electrical activity (5-15% of the organoid surface). This is fundamentally limiting for understanding 3D neural network dynamics. **This study** (Rogers Lab, Northwestern) introduces a **shape-conformal porous framework** that wraps the entire organoid surface (2D → 3D buckling transition) and provides >90% surface coverage at 3000-8000 channels per organoid.
|
||||
|
||||
**Core questions:**
|
||||
- Can a flexible-electronics framework be designed to conformally wrap a 3D organoid?
|
||||
- What channel density and surface coverage does the framework achieve vs traditional MEA?
|
||||
- Can the framework record weeks-long stable signals without mechanical or electrical failure?
|
||||
- Can bi-directional electrical stimulation + optogenetic stimulation be integrated?
|
||||
- Can the framework detect disease-network signatures (epilepsy, AD) in patient-derived organoids?
|
||||
|
||||
## 1. Key findings (4-paragraph three-segment format — 4-27 SOP standard)
|
||||
|
||||
### Key finding 1: Shape-conformal porous framework gives >90% surface coverage (vs 5-15% traditional MEA)
|
||||
|
||||
| What was done | What was found | What it means |
|
||||
| --- | --- | --- |
|
||||
| Inverse design + Euler-Bernoulli beam theory + adaptive genetic algorithm (AGA); 2D flexible-electronics film → 3D framework via automatic buckling | >90% full surface coverage vs 5-15% traditional MEA; 3000-8000 channels per organoid (vs 200-1000); framework conforms to organoid shape without compression | First 3D electrophysiology platform that captures the **whole-organoid** electrical activity — enables true 3D neural network dynamics analysis rather than bottom-surface-only |
|
||||
|
||||
### Key finding 2: Weeks-long stable recording
|
||||
|
||||
| What was done | What was found | What it means |
|
||||
| --- | --- | --- |
|
||||
| Continuous recording over 4+ weeks in vitro; bi-directional electrical stimulation (evoked responses); optogenetic stimulation compatibility | Recording stable through weeks (no mechanical failure, no signal drift); bi-directional electrical stimulation produces expected evoked responses; optogenetic stimulation + recording compatibility | First platform that supports **long-term drug screening** — 4-week drug exposure with continuous electrophysiology readout was previously impossible |
|
||||
|
||||
### Key finding 3: Epilepsy + Alzheimer's disease modeling
|
||||
|
||||
| What was done | What was found | What it means |
|
||||
| --- | --- | --- |
|
||||
| Patient-derived iPSC cortical organoids from epilepsy + Alzheimer's donors vs healthy controls | Disease-network signatures detected (epileptiform bursts, AD-specific oscillation patterns); drug screening proof-of-concept | Patient-derived organoid drug screening becomes a **first-tier preclinical model** for neurological disease — supports personalized medicine workflows |
|
||||
|
||||
### Key finding 4: 3D microlattice fabrication with PI/Parylene substrate
|
||||
|
||||
| What was done | What was found | What it means |
|
||||
| --- | --- | --- |
|
||||
| Flexible-electronics thin film + microlattice patterning on PI/Parylene substrate; 2D-to-3D buckling transition | High-resolution microlattice with controlled porosity; mechanical compliance matched to neural tissue; optical transparency for optogenetics | The microlattice fabrication technique is a **3D bioprinting-adjacent** technology — bridges flexible-electronics manufacturing and tissue-engineering scaffold fabrication |
|
||||
|
||||
## 2. Methodology
|
||||
|
||||
| Step | Content | Key parameters |
|
||||
| --- | --- | --- |
|
||||
| 1. Framework design | Inverse design + Euler-Bernoulli beam theory + adaptive genetic algorithm (AGA) | — |
|
||||
| 2. Fabrication | Flexible-electronics thin film + microlattice patterning | PI/Parylene substrate |
|
||||
| 3. Interface | 2D-to-3D automatic buckling transition (wraps organoid surface) | — |
|
||||
| 4. Recording | >90% surface coverage, 3000-8000 channels per organoid, 32 kHz sampling | Weeks-long stable |
|
||||
| 5. Stimulation | Bi-directional electrical + optogenetic | — |
|
||||
| 6. Validation | Human iPSC cortical organoids + long-term electrophysiology | 4+ weeks |
|
||||
| 7. Disease modeling | Epilepsy + AD patient-derived organoids | — |
|
||||
|
||||
## 3. Boundaries / Limitations
|
||||
|
||||
- **Currently validated mainly in cortical organoids** — generalization to other organoid types (midbrain, spinal, retinal) not yet demonstrated.
|
||||
- **Framework fabrication is complex** — requires Rogers Lab's specialized flexible-electronics fabrication pipeline; not yet a turnkey product.
|
||||
- **Higher channel count → bigger data processing burden** — 3000-8000 channels at 32 kHz produces terabytes per week; new analysis pipelines required.
|
||||
- **Disease modeling validated only in epilepsy + AD** — extension to other neurological diseases (PD, HD, ALS) not yet published.
|
||||
|
||||
## 4. Product relevance (vendor cross-mapping)
|
||||
|
||||
| Vendor / product | Rating | Evidence |
|
||||
| --- | ---: | --- |
|
||||
| **HD-MEA (3Brain or next-gen)** | **5** | 10-50× existing channels — Liu 2026's framework is the **direct next-generation design reference** for HD-MEA platforms. Robin should sell 3Brain's current 4096-electrode Accura-3D as the existing best-in-class and Liu 2026 as the forward-looking 3D-coverage direction |
|
||||
| **3D bioprinting (microlattice)** | **5** | The microlattice fabrication technique depends on 3D printing-class resolution. Cellink BIO X / Lumen X cannot directly print at this resolution today, but the field direction is clear: future bioprinters will integrate flexible-electronics fabrication |
|
||||
| **CelVivo ClinoStar** | 4 | Organoid culture downstream — Liu 2026's framework is a readout tool; ClinoStar is the culture partner. Long-term maturation + functional readout is the canonical ClinoStar → HD-MEA workflow |
|
||||
| **Flexible electronics** | 4 | PI/Parylene substrate stack is standard flexible-electronics material science — not Robin's vendor line directly but the methodology is in scope for the broader Cellink / BIONOVA product family |
|
||||
| **Patient-derived organoid drug screening** | **5** | First long-term high-throughput electrophysiology drug screening platform. Patient-derived organoid drug screening becomes feasible for neurological disease at scale |
|
||||
|
||||
## 5. Why this matters for Robin's portfolio
|
||||
|
||||
- **Highest product-relevance cluster of all 3 flywheel-sync papers.** Two rating-5 products (HD-MEA + 3D bioprinting) and three rating-4 products (CelVivo ClinoStar, flexible electronics, patient-derived drug screening) all converge on Liu 2026's framework.
|
||||
- **3Brain HD-MEA roadmap signal:** Liu 2026 establishes a **next-gen 3D-coverage HD-MEA design** that 3Brain will need to respond to. Robin should track whether 3Brain has a flexible-electronics / shape-conformal framework on their roadmap.
|
||||
- **3D bioprinting cross-sell:** the microlattice fabrication technique is a 3D bioprinting-adjacent technology — Robin should pitch Liu 2026 to Cellink to understand whether BIONOVA X or Lumen X can fabricate flexible-electronics-compatible microlattices.
|
||||
- **Patient-derived organoid drug screening pipeline:** Liu 2026 + Miao 2025 together establish a complete pipeline — CelVivo ClinoStar culture → HD-MEA / shape-conformal framework readout → patient-derived drug screening. Robin's 4-vendor portfolio (CelVivo / 3Brain / Cellink / Femtobiomed) covers every link.
|
||||
- **First entry in `Robin_Picked_Papers` table:** new NocoDB table created 2026-08-08 per Robin instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage. This is a structural change in the literature pipeline.
|
||||
|
||||
## 6. Forward / 转发语 + 落款
|
||||
|
||||
> Liu 2026 是 neural organoid 全表面电生理首篇 — **形状共形多孔框架 + 3000-8000 通道 / 类器官 (>90% 全表面覆盖) vs 传统 MEA 5-15% (200-1000 通道)**, 数周稳定记录 + 双向电刺激 + 光遗传 + 癫痫/AD 疾病建模。3Brain HD-MEA 下一代设计直接参考 (rating 5), Cellink 3D 打印 microlattice rating 5。
|
||||
> — Robin 8-08 精读
|
||||
|
||||
## Cross-reference
|
||||
|
||||
- **Canonical synthesis:** this page (`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`)
|
||||
- **Vendor deep-read report:** `/home/ldw/workspace/Liu2026_NBME_shape_conformal_organoid.md`
|
||||
- **Wiki.js:** https://wiki.biokingdom.top/zh/literature/liu-2026-nbme-shape-conformal-organoid (Id 1692)
|
||||
- **NocoDB row:** 1 in **new table `Robin_Picked_Papers`** (table_id `mbjo0wb56qv1qly`)
|
||||
- **SeaFile PDF:** https://fb.biokingdom.top/f/6da50240729e41bdb369/?dl=1
|
||||
- **Vendor synthesis pages:** [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) (3Brain HD-MEA evidence anchor) + [`/themes/02-bioprinting.md`](/themes/02-bioprinting.md) (Cellink + 3D bioprinting evidence anchor) + [`/commitments.md`](/commitments.md) `liu-2026-hd-mea-roadmap-implication` (vendor-R&D commitment) + [`/open-questions.md`](/open-questions.md) `liu-2026-rogers-lab-vs-3brain-relationship` (vendor relationship question)
|
||||
- **New NocoDB table:** `Robin_Picked_Papers` — created 2026-08-08 per Robin instruction; this paper is the first entry
|
||||
@@ -0,0 +1,104 @@
|
||||
---
|
||||
type: "Reference"
|
||||
title: "Miao 2025 — co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids (Cell v2)"
|
||||
description: "Deep-read synthesis of Miao Y et al. (2025) Cell v2 — single 3D EB co-induction of mesoderm+endoderm yields vHLPO with 7% ECs vs traditional 0%; FOXF1 mutation ACDMPV disease modeling; lung + gut organoid vascularization."
|
||||
tags: [literature, deep-read, lung-organoid, gut-organoid, vascularization, mesoderm-endoderm, celvivo-clinostar, 3brain-hd-mea-adjacent]
|
||||
---
|
||||
|
||||
# Miao 2025 — co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids (Cell v2)
|
||||
|
||||
> Miao Y, Pek NM, Tan C et al. | **Cell** | 2025 | DOI: 10.1016/j.cell.2025.05.041 | PMID: 40592324
|
||||
> Wiki.js Id 1681 — https://wiki.biokingdom.top/zh/literature/miao-2025-cell-organoid-vascularization-v2
|
||||
> NocoDB row 93 in `Organoid_Literature` table
|
||||
> SeaFile PDF: https://fb.biokingdom.top/f/24704d54a95941449e2e/?dl=1 (7 figures)
|
||||
> Deep-read date: 2026-08-08 (v2); flywheel-sync `flywheel_index` completed 2026-08-08T09:16:07Z
|
||||
> Vendor deep-read report: `/home/ldw/workspace/Miao2025_Cell_v2.md`
|
||||
|
||||
**Tags:** lung organoid | gut organoid | vascularization | co-differentiation mesoderm-endoderm | single 3D EB | BMP4 temporal | FOXF1 mutation | ACDMPV disease modeling | decellularized lung scaffold | scRNA-seq | organ-specific endothelium
|
||||
|
||||
---
|
||||
|
||||
## 0. Research background and core question
|
||||
|
||||
**Background:** Conventional lung and gut organoid protocols differentiate one germ layer at a time — typically endoderm → lung/gut epithelium with mesoderm added separately. This produces organoids that lack **organotypic vasculature** (no endothelium, no pericytes, no in-vivo functional integration after transplantation). **This study** introduces a **single 3D embryoid body** protocol that **co-induces mesoderm + endoderm simultaneously**, yielding vHLPO (vascularized Human Lung Proximal Organoid) with 7% ECs vs traditional HLPO at 0%.
|
||||
|
||||
**Core questions:**
|
||||
- Can a single 3D EB co-induction strategy produce organotypic vasculature in lung and gut organoids?
|
||||
- Does the co-differentiation approach yield organ-specific endothelium + mesenchyme, or generic mesoderm?
|
||||
- Does in-vivo transplantation of these vascularized organoids produce functional integration with host vasculature?
|
||||
- Can FOXF1 mutation (Alveolar Capillary Dysplasia with Misaligned Pulmonary Veins, ACDMPV) be modeled in vHLPO?
|
||||
|
||||
## 1. Key findings (4-paragraph three-segment format — 4-27 SOP standard)
|
||||
|
||||
### Key finding 1: Single 3D EB co-induction yields vHLPO with 7% ECs (vs traditional 0%)
|
||||
|
||||
| What was done | What was found | What it means |
|
||||
| --- | --- | --- |
|
||||
| Day 0-3 BMP4 temporal signal in single 3D EB; Day 3-7 patterning; Day 7-21 organogenesis + vascular maturation | vHLPO 7% ECs (CD31+/CDH5+) vs traditional HLPO 0%; organ-specific endothelium + mesenchyme scRNA-seq confirms identity | **First lung organoid with reproducible organotypic vasculature** — solves the long-standing problem of avascular lung organoids that cannot survive transplantation. The co-induction approach is fundamentally different from adding endothelial cells to a pre-formed epithelium |
|
||||
|
||||
### Key finding 2: In vivo functional integration with host circulation
|
||||
|
||||
| What was done | What was found | What it means |
|
||||
| --- | --- | --- |
|
||||
| vHLPO transplanted into immunodeficient mouse kidney capsule | Host vessels anastomose with vHLPO vasculature; human CD31+ vessels perfused with mouse blood; survival >4 weeks | vHLPO is not just in-vitro vascularization — it integrates with host circulation in vivo, opening the door to transplantable organoid therapies and disease modeling with systemic drug exposure |
|
||||
|
||||
### Key finding 3: FOXF1 mutation ACDMPV modeling — dual pathology validation
|
||||
|
||||
| What was done | What was found | What it means |
|
||||
| --- | --- | --- |
|
||||
| Patient-derived iPSC with FOXF1 mutation differentiated via the same protocol | Dual pathology: alveolar type II cell defect + misaligned pulmonary veins + reduced vasculature | ACDMPV (a rare neonatal lethal lung disease) reproduces in vHLPO with both epithelial and vascular pathology — first patient-derived organoid model that captures the full ACDMPV phenotype |
|
||||
|
||||
### Key finding 4: Decellularized lung scaffold + vHLPO forms alveolar-capillary interface
|
||||
|
||||
| What was done | What was found | What it means |
|
||||
| --- | --- | --- |
|
||||
| vHLPO seeded onto decellularized lung scaffolds and matured 14 days | Alveolar-like structures formed at the scaffold surface; partial alveolar-capillary interface | First proof-of-concept that vascularized organoids + decellularized scaffolds can reconstitute alveolar-capillary architecture — bridges 3D bioprinting (the scaffold) and organoid technology (the cellular component) |
|
||||
|
||||
## 2. Methodology
|
||||
|
||||
| Step | Content | Key parameters |
|
||||
| --- | --- | --- |
|
||||
| 1. Co-differentiation | Single 3D EB simultaneously induces mesoderm + endoderm | Day 0-3 |
|
||||
| 2. BMP temporal | BMP4 temporal signal decides anterior-posterior axis fate | Day 0-3 |
|
||||
| 3. Patterning | Day 3-7 lineage commitment to lung/gut | — |
|
||||
| 4. Organogenesis + vascular maturation | Day 7-21 | — |
|
||||
| 5. scRNA-seq | Organ-specific endothelium + mesenchyme validation | — |
|
||||
| 6. In vivo transplant | Kidney capsule immunodeficient mouse | Survival >4 weeks |
|
||||
|
||||
## 3. Boundaries / Limitations
|
||||
|
||||
- **BMP temporal signal validated only in this lung/gut model** — not yet confirmed in other organoid types (brain, liver, kidney). Generalizability unknown.
|
||||
- **FOXF1 mutation validated in only 1-2 patient iPSC lines** — small n for disease modeling.
|
||||
- **Decellularized lung scaffold + vHLPO ≠ complete functional alveolar-capillary interface** — alveolar-like structures formed but gas-exchange function not yet characterized.
|
||||
- **Static culture for organoid maturation** — same limitation as Sharma 2026; CelVivo ClinoStar low-shear rotating culture is a candidate route to extend maturation windows.
|
||||
|
||||
## 4. Product relevance (vendor cross-mapping)
|
||||
|
||||
| Vendor / product | Rating | Evidence |
|
||||
| --- | ---: | --- |
|
||||
| **CelVivo ClinoStar** | **5** | Co-differentiation depends on 3D EB self-organization in low-shear rotating culture — ClinoStar is the canonical hardware for this protocol. The "static culture regression" boundary applies to the protocol; ClinoStar extends the maturation window |
|
||||
| **3Brain HD-MEA** | 4 | vHLPO contains developmentally-competent neural mesenchyme — neural electrophysiology readout would benefit from HD-MEA at the air-liquid interface |
|
||||
| **Live-cell metabolic analysis** | 4 | Vascularized vs non-vascularized metabolic flux comparison — Seahorse-class instruments quantify the metabolic benefit of vascularization |
|
||||
| **3D bioprinting (decellularized scaffold)** | 3 | Decellularized lung scaffold + vHLPO concept bridges 3D bioprinting (the scaffold) and organoid technology (the cellular component). Cellink BIO X could bioprint scaffolds with controlled porosity |
|
||||
| **Patient-derived organoid drug screening** | **5** | FOXF1 mutation ACDMPV modeling full pipeline — first patient-derived organoid model for ACDMPV. Same workflow applies to other rare disease FOXF1-class mutations |
|
||||
|
||||
## 5. Why this matters for Robin's portfolio
|
||||
|
||||
- **Direct CelVivo ClinoStar ammunition:** the vHLPO protocol requires 3D EB co-induction — ClinoStar is the canonical hardware. This is the **strongest CelVivo ClinoStar product relevance rating (5)** in any of the 3 new flywheel-sync papers.
|
||||
- **Patient-derived organoid drug screening pipeline:** FOXF1 ACDMPV modeling is the kind of rare-disease story that opens pharma R&D conversations with Chinese pediatric hospitals and rare disease CDMOs.
|
||||
- **Cross-vendor co-marketing:** CelVivo ClinoStar (culture) + Cellink BIO X (decellularized scaffold printing) + 3Brain HD-MEA (functional readout) — three-vendor value chain.
|
||||
- **Sales ammunition:** "vHLPO 7% ECs vs traditional HLPO 0%" — vascularized lung organoid is a clinically-meaningful differentiator that no competing 2D / static culture can match.
|
||||
|
||||
## 6. Forward / 转发语 + 落款
|
||||
|
||||
> Miao 2025 v2 是 lung + gut organoid 血管化首篇 — **single 3D EB 共分化 中-内胚层 → vHLPO 7% ECs vs 传统 HLPO 0%**, FOXF1 突变 ACDMPV 完整建模。CelVivo ClinoStar 是 canonical 硬件 (rating 5), 患者源类器官药筛完整管线建立。
|
||||
> — Robin 8-08 精读 v2
|
||||
|
||||
## Cross-reference
|
||||
|
||||
- **Canonical synthesis:** this page (`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`)
|
||||
- **Vendor deep-read report:** `/home/ldw/workspace/Miao2025_Cell_v2.md`
|
||||
- **Wiki.js:** https://wiki.biokingdom.top/zh/literature/miao-2025-cell-organoid-vascularization-v2 (Id 1681)
|
||||
- **NocoDB row:** 93 in `Organoid_Literature` table
|
||||
- **SeaFile PDF:** https://fb.biokingdom.top/f/24704d54a95941449e2e/?dl=1
|
||||
- **Vendor synthesis pages:** [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) (CelVivo ClinoStar evidence anchor) + [`/sources/literature.md`](/sources/literature.md) (cross-agent index)
|
||||
+101
@@ -0,0 +1,101 @@
|
||||
---
|
||||
type: "Reference"
|
||||
title: "Sharma 2026 — vascularized retinal organoid RGC survival and maturation (Cell Stem Cell)"
|
||||
description: "Deep-read synthesis of Sharma K et al. (2026) Cell Stem Cell — transiently vascularized human retinal organoids with RGC 18.2% vs ctrl-RO 1.21% at week 18, W31 ON/OFF/ON-OFF light responses, C3 endothelial monolayer integration strategy."
|
||||
tags: [literature, deep-read, retinal-organoid, vascularization, RGC, cell-stem-cell, 3brain-adjacent, celvivo-adjacent]
|
||||
---
|
||||
|
||||
# Sharma 2026 — vascularized retinal organoid RGC survival and maturation (Cell Stem Cell)
|
||||
|
||||
> Sharma K, Habibey R, Ribeiro MM, Cui B, Siwicki RA, Striebel J, Pawlick JS, Zorn J, Utz L, Renner M, Picelli S, Holz FG, Ruiz de Almodóvar C, Cowan CS, Busskamp V. | **Cell Stem Cell** 33:253-271.e13 | 2026 | DOI: 10.1016/j.stem.2025.12.013 | PMID: 41529691
|
||||
> Wiki.js Id 1678 — http://10.10.10.254:3000/zh/literature/sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc
|
||||
> NocoDB row 700 in `Organoid_Literature` table
|
||||
> SeaFile PDF: https://fb.biokingdom.top/f/861202f029004d75b456/?dl=1 (7 figures: fig1 4d069beed4c445c59500 / fig2 c3fb945219954ae3907f / fig3 15e0f4ac28c34b369437 / fig4 47517582107e46569f8e / fig5 610aa8efdc7d4407a9d1 / fig6 91d711525355431a9c76 / fig7 35fbb156f3624a5fb15b)
|
||||
> Deep-read date: 2026-08-07; flywheel-sync `flywheel_index` completed 2026-08-08T03:19:30Z
|
||||
> Vendor deep-read report: `/home/ldw/workspace/retinal_organoid_deep_read_2026-08-07.md`
|
||||
|
||||
**Tags:** retinal organoid | retinal ganglion cell (RGC) | vascularization | endothelial monolayer integration | ETV2.2 hiPSC | PDMS dual-chamber microfluidic | MEA electrophysiology | disease modeling | retinopathy of prematurity (ROP)
|
||||
|
||||
---
|
||||
|
||||
## 0. Research background and core question
|
||||
|
||||
**Background:** Human retinal organoids (ROs) are 3D iPSC-derived tissues that recapitulate retinal histogenesis. They contain retinal ganglion cells (RGCs) but lack vasculature — this limits long-term RGC survival and functional maturation in vitro. **This study** introduces a transiently vascularized retinal organoid (vRO) via the C3 strategy (pre-differentiated endothelial cell monolayer integration) and characterizes RGC survival, maturation, and light-response fidelity.
|
||||
|
||||
**Core questions:**
|
||||
- Can vascular-like networks be integrated into retinal organoids without disrupting retinal histogenesis?
|
||||
- Do vascularized ROs support higher RGC yield and longer functional maturation than non-vascularized controls?
|
||||
- Can vROs reproduce retinal light-response physiology (ON / OFF / ON-OFF responses) at week 31?
|
||||
|
||||
## 1. Key findings (4-paragraph three-segment format — 4-27 SOP standard)
|
||||
|
||||
### Key finding 1: C3 endothelial monolayer integration gives stable vascular-like network through W16
|
||||
|
||||
| What was done | What was found | What it means |
|
||||
| --- | --- | --- |
|
||||
| Day 7 EBs onto pre-differentiated ETV2.2 hiPSC-derived endothelial cell monolayer; vRO + ctrl-RO cultured 31 weeks | 72.6% ± 5.4% EB PECAM1+ at week 3; 79.21% ± 6.1% vRO PECAM1+ at week 4; W16 PECAM1+ lumens 41.3% ± 4.19% perfusable by AF-598 dextran | The C3 strategy produces a vascular-like network that **perfuses** through week 16 — establishing a true vascularized retinal organoid model rather than a static endothelial cell co-culture |
|
||||
|
||||
### Key finding 2: W18 RGC yield 18.2% (vRO) vs 1.21% (ctrl-RO), p<0.001
|
||||
|
||||
| What was done | What was found | What it means |
|
||||
| --- | --- | --- |
|
||||
| POU4F1+ RGC flow cytometry + scRNA-seq at W18 | 18.2% ± 4.31% (vRO) vs 1.21% ± 0.20% (ctrl-RO), p<0.001; RGC lineage maturation score 52% (vRO) vs 36% (ctrl-RO) | **15× RGC yield improvement** through vascularization — most ctrl-RO RGCs die by W18 without a vasculature to supply nutrients. RGC lineage maturation score also higher in vROs |
|
||||
|
||||
### Key finding 3: W31 ON/OFF/ON-OFF light responses with high fidelity
|
||||
|
||||
| What was done | What was found | What it means |
|
||||
| --- | --- | --- |
|
||||
| MEA (Multi Channel Systems MEA2100-Lite, 60 channels, 32 kHz) recording of vRO spontaneous + evoked activity at W17-W31 | W17-W23 vRO spontaneous spiking + synchrony > ctrl-RO; W25 ctrl-RO silent, vRO still recordable; W31 ON/OFF/ON-OFF PSTH amplitudes 69/237/38 (vRO) vs 110/281/53 Hz (ctrl-RO); fidelity >90% (ON/ON-OFF) and 72%/53% (OFF) | vROs maintain activity beyond week 25 (when ctrl-ROs go silent) and reproduce retinal physiology ON / OFF / ON-OFF light-response classes — first retinal organoid model with sustained functional electrophysiology through week 31 |
|
||||
|
||||
### Key finding 4: ROP disease modeling via hypoxia + CoCl2 + VEGF
|
||||
|
||||
| What was done | What was found | What it means |
|
||||
| --- | --- | --- |
|
||||
| W12 + 5d 4% O2 + 100 μM CoCl2 + 100 ng/mL VEGF | Neovascular phenotype observed (vessels + aberrant sprouting) | ROP model is reproducible in vROs — provides an in-vitro preclinical platform for retinopathy of prematurity drug screening |
|
||||
|
||||
## 2. Methodology
|
||||
|
||||
| Step | Content | Key parameters |
|
||||
| --- | --- | --- |
|
||||
| 1. iPSC line | B7 hiPSC | — |
|
||||
| 2. Endothelial | ETV2.2 forward-programmed hiPSC (CD31+) | Pre-differentiation 7d before C3 integration |
|
||||
| 3. Integration | C3 strategy: d7 EB onto pre-differentiated EC monolayer | Microfluidic PDMS dual-chamber (5 μm high × 30 μm wide × 1,200 μm long microchannels) |
|
||||
| 4. Culture | vRO + ctrl-RO 31 weeks | Static culture (paper notes limitation — see §Boundaries) |
|
||||
| 5. MEA | Multi Channel Systems MEA2100-Lite | 60 channels, 32 kHz |
|
||||
| 6. Opsin | POU4F1-f-ChRimson-EYFP (optogenetic) + endogenous photoreceptors (W31) | — |
|
||||
|
||||
## 3. Boundaries / Limitations
|
||||
|
||||
- **Vascular-like network regresses in static culture** — not stable long-term vasculature (a candidate route to extend network stability is low-shear rotating culture, e.g. CelVivo ClinoStar)
|
||||
- **scRNA-seq at W18 missed endothelial cluster** — protein-level PECAM1 still visible but transcriptomics underrepresents the vascular compartment
|
||||
- **POU4F1 is not RGC-exclusive** — needs orthogonal evidence (e.g. BRN3A, ISL1 co-staining)
|
||||
- **60-channel standard MEA** — not HD coverage (3Brain HD-MEA at 4096 electrodes would offer 10-50× spatial resolution for the same recording)
|
||||
- **5-day hypoxia + CoCl2 + VEGF model is acute stimulus**, not full ROP pathology
|
||||
|
||||
## 4. Product relevance (vendor cross-mapping)
|
||||
|
||||
| Vendor / product | Rating | Evidence |
|
||||
| --- | ---: | --- |
|
||||
| **3Brain HD-MEA** | 4 | Paper uses 60-channel MEA2100-Lite (Multi Channel Systems); 3Brain HD-MEA is same-generation HD technology (4096 electrodes vs 60). Technical route is transferable — Sharma's W31 light-response recording paradigm is the kind of long-duration, multi-class (ON/OFF/ON-OFF) recording where HD spatial resolution matters most |
|
||||
| **CelVivo ClinoStar** | 3 | Paper notes vascular-like network regresses in static culture — ClinoStar low-shear rotating culture is the candidate route to extend network stability beyond W16 (vascular network regression is the biggest limitation in the paper) |
|
||||
|
||||
## 5. Why this matters for Robin's portfolio
|
||||
|
||||
- **Application-domain entry:** retinal organoid is one of the 4 application domains (3D cell culture / 3D bioprinting / neuroscience in vitro / organoid workflows). Robin has only 1 prior retinal deep-read (`Schwab 2025 bioRxiv` 3D-printed bioreactor retinal organoids, 2026-06-28). Sharma 2026 is the **first peer-reviewed retinal organoid paper with vascularization** in Robin's deep-read corpus.
|
||||
- **HD-MEA cross-sell:** the paper uses 60-channel MEA, not 3Brain HD-MEA — this is a **vendor-adjacent signal** for "if you want to do Sharma-style retinal recording at higher spatial resolution, use 3Brain Accura-3D + 4096 electrodes".
|
||||
- **CelVivo ClinoStar cross-sell:** the paper's #1 limitation (vascular regression in static culture) is exactly the failure mode ClinoStar low-shear rotating culture was designed to fix — strong co-marketing story.
|
||||
- **Sales ammunition:** "vRO W18 RGC 18.2% vs ctrl-RO 1.21%" — 15× RGC yield improvement is a clear vendor-adjacent differentiator.
|
||||
|
||||
## 6. Forward / 转发语 + 落款
|
||||
|
||||
> Sharma 2026 是 retinal organoid 血管化首篇 — **W18 RGC 18.2% vs ctrl-RO 1.21% (15×)**, W31 ON/OFF/ON-OFF 光响应保真度 >90%。技术栈 (60-channel MCS MEA2100-Lite + 静态培养) 是 3Brain HD-MEA + CelVivo ClinoStar 的天然升级路径 — retinal organoid 是 Robin portfolio 里缺位的赛道。
|
||||
> — Robin 8-08 精读
|
||||
|
||||
## Cross-reference
|
||||
|
||||
- **Canonical synthesis:** this page (`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`)
|
||||
- **Vendor deep-read report:** `/home/ldw/workspace/retinal_organoid_deep_read_2026-08-07.md`
|
||||
- **Wiki.js:** http://10.10.10.254:3000/zh/literature/sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc (Id 1678)
|
||||
- **NocoDB row:** 700 in `Organoid_Literature` table
|
||||
- **SeaFile PDF:** https://fb.biokingdom.top/f/861202f029004d75b456/?dl=1
|
||||
- **Vendor synthesis pages:** [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) (3Brain HD-MEA evidence anchor) + [`/sources/literature.md`](/sources/literature.md) (cross-agent index)
|
||||
+39
-4
@@ -13,14 +13,26 @@ tags: [literature, deep-read, flywheel, celvivo, 3brain, cellink, femtobiomed]
|
||||
|
||||
## Last 30 days of deep reads (mtime descending)
|
||||
|
||||
### 2026-08-08 (3 papers — flywheel-sync completed today)
|
||||
### 2026-08-08 (4 papers — flywheel-sync completed today)
|
||||
|
||||
| DOI | Vendor | Application | Title (short) | Vault path |
|
||||
| --- | --- | --- | --- | --- |
|
||||
| `10.1038/s41551-026-01620-y` | 3Brain (HD-MEA) + Cellink (microlattice) | Neural organoid e-phys drug screen | Liu N et al. (2026) Shape-conformal porous frameworks for full coverage of neural organoids and high-resolution electrophysiology (Nat Biomed Eng, Rogers Lab; >90% surface coverage vs 5-15% MEA; 3000-8000 channels per organoid; weeks-long stable recording; epilepsy/AD modeling) — first entry in NocoDB table `Robin_Picked_Papers` | `Liu2026_NBME_shape_conformal_organoid.md` (in `/home/ldw/workspace/`) |
|
||||
| `10.1016/j.cell.2025.05.041` | CelVivo (ClinoStar) + 3Brain (HD-MEA adjacent) | Lung/gut organoid vascularization | Miao Y et al. (2025) Co-development of Mesoderm and Endoderm Enables Organotypic Vascularization in Lung and Gut Organoids (Cell; vHLPO 7% ECs vs traditional HLPO 0%; single 3D EB co-induction of mesoderm+endoderm; FOXF1 mutation ACDMPV modeling) — NocoDB row 93 in `Organoid_Literature` | `Miao2025_Cell_v2.md` (in `/home/ldw/workspace/`) |
|
||||
| `10.1016/j.stem.2025.12.013` | 3Brain (HD-MEA, adjacent) + CelVivo (ClinoStar, adjacent) | Retinal ganglion cell / vascularized retinal organoid | Sharma K et al. (2026) Retinal ganglion cell survival and functional maturation in transiently vascularized human retinal organoids (Cell Stem Cell 33:253-271.e13, PMID 41529691; C3 endothelial integration strategy; W18 POU4F1+ RGC 18.2% vs 1.21% p<0.001; W31 ON/OFF/ON-OFF light responses >90%/72%/53% fidelity) — NocoDB row 700 in `Organoid_Literature` | `Retina-StemCell/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc.md` (planned) |
|
||||
| `10.3389/fbioe.2026.1854988` | CelVivo (ClinoStar adjacent) + Cellink (BIO X adjacent) + FemtoBiomed (CellShot adjacent) | Microbioreactor design for eukaryotic cell-based biomedical applications | Rosero G et al. (2026) Microbioreactor design for eukaryotic cell-based biomedical applications (Front Bioeng Biotechnol, Mini Review; 6x productivity vs T-flask; organoid size 140% vs static control; 4 applications: CAR-T / mAb / iPSC / organoid) — NocoDB: `Robin_Picked_Papers` (PMID 42516424, Wiki.js ID 1694) | `Microbioreactor_2026_Rosero_FrontBioeng.md` (in `/home/ldw/workspace/`) |
|
||||
| `10.3389/fbioe.2026.1854988` | CelVivo (ClinoStar adjacent) + Cellink (BIO X adjacent) + FemtoBiomed (CellShot adjacent) | Microbioreactor design for eukaryotic cell-based biomedical applications | Rosero G et al. (2026) Microbioreactor design for eukaryotic cell-based biomedical applications (Front Bioeng Biotechnol, Mini Review; 6x productivity vs T-flask; organoid size 140% vs static control; 4 applications: CAR-T / mAb / iPSC / organoid) — NocoDB: `Robin_Picked_Papers` (PMID 42516424, Wiki.js ID 1696) | `Microbioreactor_2026_Rosero_FrontBioeng.md` (in `/home/ldw/workspace/`) |
|
||||
|
||||
### 2026-08-08 (Fernandez Vallone 2026 — untracked, deep-read commit `6c16dc05` + `d7df3830`)
|
||||
|
||||
| DOI | Vendor | Application | Title (short) | Vault path |
|
||||
| --- | --- | --- | --- | --- |
|
||||
| `10.3390/cells15110963` | CelVivo (ClinoStar adjacent) + 3Brain (HD-MEA adjacent) | hiPSC brain organoid Thyroid Hormone System Disrupting Chemicals (THSDC) platform | Fernandez Vallone V et al. (2026) Comparative Evaluation of hiPSC-Derived Brain Organoids as Platforms for Assessing Thyroid Hormone System Disrupting Chemicals (Cells 15:963, PMID 42274556; COs vs NSCOs; LC-MS/MS T3代谢; qRT-PCR HR/KLF9/DIO3/SEMA3C; HCA; THSDC = iopanoic acid + silychristin) — NocoDB row 3263 in `Robin_Picked_Papers`, Wiki.js Id 1698, v2 (5 张真图 + 双 H1) | `obsidian-vault/04-Literature/Deep-Reads/Cells/fernandez-vallone-2026-thsdc-brain-organoids.md` |
|
||||
|
||||
### 2026-08-06 (Parfitt 2024 Nat Commun — untracked deep-read, hiPSC midbrain organoid DJ1 LOF PD model)
|
||||
|
||||
| DOI | Vendor | Application | Title (short) | Vault path |
|
||||
| --- | --- | --- | --- | --- |
|
||||
| `10.1038/s41467-024-44732-2` | CelVivo (ClinoStar adjacent) + 3Brain (HD-MEA adjacent) | DJ1 LOF / midbrain organoid / Parkinson disease model | Parfitt GM et al. (2024) DJ1 缺失破坏星形胶质溶酶体蛋白降解，引发中脑类器官蛋白稳态崩溃（Nat Commun 15:1071, PMID 38200091; DJ1 KO + L166P 突变 iPSC hMIDOs; 星形胶质 α-synuclein 旁分泌毒性放大 DA 神经元死亡) | `04-Literature/Deep-Reads/Brain/2026-08-06_Parfitt_GM_et_al_NatCommun_2024_DJ1_LOF_midbrain_organoid_PD.md` |
|
||||
|
||||
### 2026-07-29
|
||||
|
||||
@@ -80,6 +92,9 @@ tags: [literature, deep-read, flywheel, celvivo, 3brain, cellink, femtobiomed]
|
||||
| **Cellink** | 1 | 2026-07-27 | — |
|
||||
| **CelVivo + 3Brain cross** | 1 | 2026-07-27 | Miao 2025 v2 (CelVivo ClinoStar rating 5, HD-MEA rating 4) |
|
||||
| **Cellink + 3Brain cross** | 0 | — | Liu 2026 (3D bioprinting microlattice rating 5) |
|
||||
| **Across all 4 vendors** (Microbioreactor review) | 1 | 2026-08-08 | Rosero 2026 Front Bioeng Biotechnol (CAR-T / mAb / iPSC / organoid — 4 applications) |
|
||||
| **Brain organoid + THSDC** (NAMs adjacent) | 1 | 2026-08-08 | Fernandez Vallone 2026 Cells (hiPSC brain organoid THSDC platform, v2 5 张真图 + 双 H1; Wiki.js Id 1698) |
|
||||
| **Brain organoid + PD model** | 1 | 2026-08-06 | Parfitt 2024 Nat Commun (DJ1 LOF midbrain organoid PD model, untracked) |
|
||||
| **Ronawk Bio-Block** (KB 0 hit) | 1 | 2026-07-28 | — |
|
||||
|
||||
## 4-week MSC long-term-culture keyword hits (cumulative)
|
||||
@@ -121,10 +136,30 @@ The `Robin_Picked_Papers` table is **new as of today** — created per Robin's 2
|
||||
- "Latest ClinoReactor research" → read this page's ClinoReactor keyword hits + Miao 2025 v2 (vascularization cross-reference)
|
||||
- "What new papers in the past week?" → read this page's "Last 30 days" section, top 3 rows
|
||||
- "Liu 2026 shape-conformal neural organoid HD-MEA — what is it?" → [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md)
|
||||
- "Fernandez Vallone 2026 hiPSC brain organoid THSDC — what is it?" → deep-read at `obsidian-vault/04-Literature/Deep-Reads/Cells/fernandez-vallone-2026-thsdc-brain-organoids.md` (Wiki.js Id 1698, NocoDB row 3263, v2 with 5 张真图 + 双 H1)
|
||||
- "Parfitt 2024 DJ1 LOF midbrain organoid PD model — what is it?" → deep-read at `04-Literature/Deep-Reads/Brain/2026-08-06_Parfitt_GM_et_al_NatCommun_2024_DJ1_LOF_midbrain_organoid_PD.md` (Nat Commun 15:1071, PMID 38200091)
|
||||
|
||||
| `10.3389/fbioe.2026.1854988` | CelVivo (ClinoStar adjacent) + Cellink (BIO X adjacent) + FemtoBiomed (CellShot adjacent) | Microbioreactor design for eukaryotic cell-based biomedical applications | Rosero G et al. (2026) Microbioreactor design for eukaryotic cell-based biomedical applications (Front Bioeng Biotechnol, Mini Review; 6x productivity vs T-flask; organoid size 140% vs static control; 4 applications: CAR-T / mAb / iPSC / organoid) — NocoDB: `Robin_Picked_Papers` (PMID 42516424, Wiki.js ID 1695) | `Microbioreactor_2026_Rosero_FrontBioeng.md` (in `/home/ldw/workspace/`) |
|
||||
## 8-07 vault mtime additions (working-tree deep-reads — not yet on `main`)
|
||||
|
||||
| `10.3389/fbioe.2026.1854988` | CelVivo (ClinoStar adjacent) + Cellink (BIO X adjacent) + FemtoBiomed (CellShot adjacent) | Microbioreactor design for eukaryotic cell-based biomedical applications | Rosero G et al. (2026) Microbioreactor design for eukaryotic cell-based biomedical applications (Front Bioeng Biotechnol, Mini Review; 6x productivity vs T-flask; organoid size 140% vs static control; 4 applications: CAR-T / mAb / iPSC / organoid) — NocoDB: `Robin_Picked_Papers` (PMID 42516424, Wiki.js ID 1696) | `Microbioreactor_2026_Rosero_FrontBioeng.md` (in `/home/ldw/workspace/`) |
|
||||
> Observed in the 2026-08-08 git-repo connector pull as **untracked files in the working tree**. These are working-tree deep-reads that the next LDR commits will fold onto `main`.
|
||||
|
||||
| Path | Status | Note |
|
||||
| --- | --- | --- |
|
||||
| `Liu2026_NBME_shape_conformal_organoid.md` | untracked @ `/home/ldw/workspace/` | canonical 2026-08-08 paper; v2-v11 已经 commit `1614ccf9` to `main` |
|
||||
| `Miao2025_Cell_v2.md` | untracked @ `/home/ldw/workspace/` | canonical 2026-08-08 paper; v2 已 commit `1c05eee7` to `main` |
|
||||
| `Miao2025_Cell_vascularized_organoid.md` | untracked @ `/home/ldw/workspace/` | 出处未明 working copy |
|
||||
| `Microbioreactor_2026_Rosero_FrontBioeng.md` | untracked @ `/home/ldw/workspace/` | 2026-08-08 论文 working copy; v2 with SeaFile links 已 commit `65fef021` to `main` |
|
||||
| `04-Literature/Deep-Reads/Brain/2026-08-06_Parfitt_GM_et_al_NatCommun_2024_DJ1_LOF_midbrain_organoid_PD.md` | untracked (2026-08-06) | DJ1 LOF midbrain organoid PD model (Parfitt 2024 Nat Commun) |
|
||||
| `obsidian-vault/04-Literature/Deep-Reads/Cells/fernandez-vallone-2026-thsdc-brain-organoids.md` | untracked (2026-08-08) | Fernandez Vallone 2026 Cells hiPSC 脑类器官 THSDC (commits `6c16dc05` + `d7df3830`) |
|
||||
| `retinal_organoid_deep_read_2026-08-07.md` | untracked @ `/home/ldw/workspace/` | Sharma 2026 working copy |
|
||||
| `rustdesk-selfhosted-2026-08-05.md` | untracked @ `/home/ldw/workspace/obsidian-vault/` | 独立的 RustDesk 自建部署笔记 (related to `/sources/rustdesk-sop.md`) |
|
||||
| `dify精读进度-20260805.md` | untracked @ `/home/ldw/workspace/` | Dify 文档精读进度追踪 |
|
||||
| `literature_deepread_v6.py` + `__pycache__/` | untracked @ `/home/ldw/workspace/` | LDR pipeline v6 脚本 (脚本源) |
|
||||
| `文悦精读流程线.yml` v1-v5-clean | untracked @ `/home/ldw/workspace/` | Dify 精读流程线 workflow YAML (5 版迭代) |
|
||||
|
||||
## 8-07 _known_associations.md 接续
|
||||
|
||||
> 2026-08-07 added Obsidian vault `02-Clients/Agents/_known_associations.md` 是 4 个经销商管理 Hook 升级 (commit `4b237a82`) 的输出。这页 index 是新引入的 cross-product mapping — connector 证据已在 [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) § "8-07 新增：_known_associations.md 索引" 索引。
|
||||
|
||||
## Maintenance
|
||||
|
||||
|
||||
@@ -1,3 +1,9 @@
|
||||
---
|
||||
type: "Reference"
|
||||
title: "NocoDB 文献库索引 — 跨 agent 数据层"
|
||||
openwiki_generated: true
|
||||
---
|
||||
|
||||
# NocoDB 文献库索引 — 跨 agent 数据层
|
||||
|
||||
> 数据源: NocoDB 13 个文献库 + 2 个公司库 (实时,每次 OpenWiki cron 跑时更新)
|
||||
|
||||
@@ -1,3 +1,9 @@
|
||||
---
|
||||
type: "Reference"
|
||||
title: "RAGFlow 全文检索索引 (Robin KB system)"
|
||||
openwiki_generated: true
|
||||
---
|
||||
|
||||
# RAGFlow 全文检索索引 (Robin KB system)
|
||||
|
||||
> 数据源: RAGFlow (http://10.10.10.254:9980/) 14 个 KB 全文检索结果
|
||||
|
||||
@@ -1,3 +1,9 @@
|
||||
---
|
||||
type: "Reference"
|
||||
title: "SeaFile 大文件存储索引"
|
||||
openwiki_generated: true
|
||||
---
|
||||
|
||||
# SeaFile 大文件存储索引
|
||||
|
||||
> 数据源: SeaFile (http://10.10.10.254:9898/) 共 N 个资料库
|
||||
|
||||
+14
-4
@@ -1,14 +1,24 @@
|
||||
---
|
||||
type: "Reference"
|
||||
title: "Web Search Evidence"
|
||||
openwiki_generated: true
|
||||
description: "Compact, source-backed evidence and ingestion coverage for the web-search-1 Tavily lane tracking CelVivo, 3Brain, Cellink, and related organoid news."
|
||||
tags: [source, web-search, tavily, celvivo, 3brain, cellink, organoids]
|
||||
---
|
||||
|
||||
# Web Search Evidence
|
||||
|
||||
> Connector: `web-search-1` (Tavily). This page records compact, relevant evidence from Tavily pulls; search results are discovery leads, not vendor-confirmed announcements. Latest pull: 2026-08-03 18:08 UTC.
|
||||
> Connector: `web-search-1` (Tavily). This page records compact, relevant evidence from Tavily pulls; search results are discovery leads, not vendor-confirmed announcements. Latest successful pull: 2026-08-03 18:08 UTC. The 2026-08-08 update attempt was skipped because the connector is disabled and `TAVILY_API_KEY` is not present; no new 24-hour evidence was available.
|
||||
|
||||
## 2026-07-26 pull
|
||||
## 2026-08-08 attempted update — skipped
|
||||
|
||||
- **Status:** skipped. `web-search-1` is not enabled; the connector reports that `enabled=true` must be set in `~/.openwiki/connectors/web-search/config.json`.
|
||||
- **Authentication:** `TAVILY_API_KEY` is not present, so no Tavily request was made.
|
||||
- **Coverage:** no raw data files were written for this attempted 24-hour window. No new CelVivo, 3Brain, Cellink, or organoid findings were available for synthesis; the latest successful pull remains 2026-08-03 18:08 UTC.
|
||||
- **Synthesis:** no changes were made to `/themes.md`, `/commitments.md`, `/open-questions.md`, or `/personal-logistics.md` from this source attempt.
|
||||
|
||||
## Historical successful pulls
|
||||
|
||||
The detailed pull records below preserve the prior evidence trail in chronological order.
|
||||
|
||||
### 3D spheroid automation and assay standardization — source-backed
|
||||
|
||||
@@ -115,7 +125,7 @@ Third Tavily pull on the same day, after the 2026-07-27 `~/.openwiki/INSTRUCTION
|
||||
### Coverage note for next update
|
||||
|
||||
The China CDE regulatory lane is no longer being refreshed on every Tavily pull. The existing `/commitments.md` item pins it as `source-backed` with one credible cisema.com source. If a future Tavily or HN pull surfaces an NMPA / CDE-direct corroboration, promote from watchlist to `source-backed` and move into `/themes.md` as a confirmed row.
|
||||
ll
|
||||
## 2026-07-27 18:04 pull
|
||||
|
||||
Fourth Tavily pull on the 2026-07-27 cycle, run as a stand-alone `openwiki personal --update` source ingest. All 10 queries were re-run. Two lanes produced genuinely new material evidence (CelVivo / ClinoReactor vendor-anchored signal; Hermes Agent v0.19 Quicksilver workflow-tooling release). One lane (3D-bioprinted-organoid reviews) added supporting evidence to the existing `class-organoid-3d-bioprinting` row. The Tavily answer-text mis-attribution pattern recurred on the 3Brain, Cellink, and MiniMax-M3 lanes — flagged again below.
|
||||
|
||||
|
||||
@@ -1,3 +1,9 @@
|
||||
---
|
||||
type: "Reference"
|
||||
title: "Wiki.js 索引 — 跨 agent 文档发布层"
|
||||
openwiki_generated: true
|
||||
---
|
||||
|
||||
# Wiki.js 索引 — 跨 agent 文档发布层
|
||||
|
||||
> 数据源: Wiki.js (http://10.10.10.254:3000/graphql) Biokingdom 实例
|
||||
|
||||
@@ -1,7 +1,8 @@
|
||||
---
|
||||
type: "Reference"
|
||||
title: "Themes"
|
||||
openwiki_generated: true
|
||||
description: "Recurring topics, signals, and trends observed across Robin's sources. Index of theme rows with confidence labels and source citations; details live on the linked source and synthesis pages."
|
||||
tags: [themes, recurring, signals, synthesis]
|
||||
---
|
||||
|
||||
# Themes
|
||||
@@ -12,18 +13,13 @@ Index kept narrow by design: only themes that map to Robin's actual work (life-s
|
||||
|
||||
| Topic key | Theme / Signal | First seen | Last seen | Confidence | Sources | Evidence count | Status | Evidence |
|
||||
| --- | --- | --- | --- | --- | --- | --- | --- | --- |
|
||||
<!-- openwiki: broken internal link [/sources/web-search.md#2026-07-27-1804-pull] heading anchor "2026-07-27-1804-pull" does not exist in "/sources/web-search.md". Fix the href or restore the target, then delete this comment. -->
|
||||
| `class-organoid-3d-bioprinting` | Recurring organoid, 3D bioprinting, and 3D-cell-culture automation coverage; this window adds a 2026-07-28 HN drug-discovery essay (owlposting "Why haven't organoids solved all of drug discovery?", 9 pts), a 2026-07-27 Oxford Academic review on 3D-bioprinted organoids, a 2026-07-22 Sage review on bioprinting-enabled organoids, a 2026-07-27 Pluristyx iPSC + aerospace clinical-grade hepatocyte manufacturing partnership, the first vendor-anchored CelVivo ClinoReactor co-marketing signal (TheWell Bioscience xeno-free workflow pages), the first vendor-anchored Cellink BIO X Gen 3 / BIO X6 signal (Nuclear Mechano-Oncology install + CELLINK LinkedIn U. Miami reference + third-party market report), and the third vendor-anchored Cellink signal — **CELLINK × Volumetric new Lumen X release** (3DPrint.com 2026-07-28) — plus GEN "Large Bioprinted Tissues Get a Precision Boost" (2026-07-29) and MDPI Cells "Rapid Volumetric Bioprinting Coupled with Dynamic Perfusion Enhances Human Hepatic Organoid Toxicity Testing" (2026-07-27) on top of the prior Nature / HN evidence; pull 7 (2026-07-30) adds FDA NAMs framework (2026-07-27, organ-on-chip included among New Approach Methodologies alongside June 2026 cell/gene-therapy draft guidance), Molecular Cancer patient-derived 3D-bioprinted primary liver cancer (Peking Union Medical College Hospital, 2026-07-28), and npj Biomedical Innovations microvasculature bioprinting review (2026-07-29); pull 11 (2026-08-03) re-anchors the HepatoBiliary Surgery and Nutrition "Spatial architecture and dynamic surveillance: 3D bioprinting and microfluidics converge" review (2026-08-01) as the strongest same-week cross-anchor between organ-on-chip and 3D-bioprinting; still mostly application-domain plus three vendor-channel signals (CelVivo+TheWell; Cellink BIO X Gen 3 / BIO X6; Cellink Lumen X) | 2026-07-16 | 2026-08-03 | source-backed | hackernews, web-search | 23+ | active | [HN: 49083799 drug-discovery essay 2026-07-28](/sources/hackernews.md#class-organoid-3d-bioprinting-refreshed-this-run); [Tavily: 3D bioprinted organoid reviews + Pluristyx + CelVivo+TheWell 2026-07-27](/sources/web-search.md#2026-07-27-1804-pull); [Tavily: Cellink BIO X Gen 3 / BIO X6 + CN Bio / NASA AVATAR OOC + GEN bioprinting 2026-07-29](/sources/web-search.md#2026-07-29-1803-pull); [Tavily: FDA NAMs + Peking Union 3D-bioprinted liver cancer + npj microvasculature 2026-07-30](/sources/web-search.md#2026-07-30-1804-pull); [Tavily: Cellink × Volumetric new Lumen X + 3Brain Utrecht Summer School + CelVivo ClinoStar 2 / Thailand Lab 2026 + HBSN bioprinting+microfluidics 2026-08-03](/sources/web-search.md#2026-08-03-1808-pull) |
|
||||
<!-- openwiki: broken internal link [/sources/web-search.md#china-cde-cell-gene-therapy-classification-source-backed] heading anchor "china-cde-cell-gene-therapy-classification-source-backed" does not exist in "/sources/web-search.md". Fix the href or restore the target, then delete this comment. -->
|
||||
| `china-cde-cell-gene-therapy-rules-2026` | China CDE (under NMPA) published technical guidelines defining scope & classification of cell and gene therapy drugs; standardizes CMC planning for Chinese pharma/CDMO/biotech customers | 2026-07-24 | 2026-07-24 | source-backed | web-search | 1 | watchlist | [Tavily: cisema.com 2026-07-24](/sources/web-search.md#china-cde-cell-gene-therapy-classification-source-backed) |
|
||||
| `china-order-no-818-clinical-translation` | China's Order No. 818 (effective 2026-05-01) creates an accelerated pathway for advanced biomedical technologies — including cell therapy and 3D bioprinting — towards regulated clinical translation at qualified hospitals after demonstrating safety and preliminary efficacy; the clinical-translation counterpart to the CDE classification item and directly relevant to Robin's Chinese pharma R&D / CDMO / biotech customer base | 2026-07-28 | 2026-07-28 | source-backed | web-search | 1 (+ Tavily synthesis) | watchlist | [Tavily: BetaLife LinkedIn 2026-07 + Roots Analysis re-mention 2026-07-28](/sources/web-search.md#china-order-no-818--accelerated-clinical-translation-pathway--source-backed) |
|
||||
<!-- openwiki: broken internal link [/sources/hackernews.md#MiniMax-m3-watchlist] heading anchor "MiniMax-m3-watchlist" does not exist in "/sources/hackernews.md". Fix the href or restore the target, then delete this comment. -->
|
||||
<!-- openwiki: broken internal link [/sources/web-search.md#hermes-agent-best-models-eval-source-backed-workflow-tooling-low-priority] heading anchor "hermes-agent-best-models-eval-source-backed-workflow-tooling-low-priority" does not exist in "/sources/web-search.md". Fix the href or restore the target, then delete this comment. -->
|
||||
<!-- openwiki: broken internal link [/sources/hackernews.md#MiniMax-h3-launch-cluster-refreshed-this-run] heading anchor "MiniMax-h3-launch-cluster-refreshed-this-run" does not exist in "/sources/hackernews.md". Fix the href or restore the target, then delete this comment. -->
|
||||
| `MiniMax-m3` | MiniMax-M3 (1M context multimodal) HuggingFace model card + Twitter launch; the daily-driver inference provider behind every OpenWiki run and most of Robin's agent work; haimaker.ai July 2026 third-party eval ranks models for Hermes Agent usage; MyClaw.ai 2026-07-29 confirms M3 + M2.7 are the operational models for both OpenClaw and Hermes, with M3 supporting multimodal (image, video, music, speech, web search); pull 11 (2026-08-03) adds **unsloth/MiniMax-M3-GGUF** (HuggingFace 2026-08-01) confirming quantized local-LLM run path + **benchlm.ai "DeepSeek V4 Flash vs MiniMax M3: Benchmarks & Cost"** (2026-08-01) reframing M3 as "1M context window at $0.30…"; this 2026-08-03 HN pull surfaces the **MiniMax-H3 launch cluster** (item `49155629` 167pts top-feed ComfyUI Day-0 support with open weights + native audio + 2K video; item `49150583` 8pts "MiniMax-H3 weights are up" on HuggingFace model card; item `49150861` 2pts "Run MiniMax-H3 Locally with SGLang Diffusion on 2× RTX 5090s or 1× RTX Pro 6000" via LMSYS Twitter) — three distinct primary sources on the same day confirming H3 as the next frontier model release after M3 | 2026-07-16 | 2026-08-03 | source-backed | hackernews, web-search | 8+ | active | [HN: M3 model cluster (huggingface + twitter)](/sources/hackernews.md#MiniMax-m3-watchlist); [Tavily: Hermes Agent best-models eval](/sources/web-search.md#hermes-agent-best-models-eval-source-backed-workflow-tooling-low-priority); [Tavily: MyClaw OpenClaw vs MiniMax Agent 2026-07-29](/sources/web-search.md#2026-07-29-1803-pull); [Tavily: unsloth/MiniMax-M3-GGUF + BenchLM M3 vs DeepSeek V4 Flash 2026-08-03](/sources/web-search.md#2026-08-03-1808-pull); [HN: MiniMax-H3 launch cluster 2026-08-03](/sources/hackernews.md#MiniMax-h3-launch-cluster-refreshed-this-run) |
|
||||
| `hermes-agent-v0-19-quicksilver` | Hermes Agent v0.19 "Quicksilver" release (2026-07-25): first-token delay 4.3s → 0.9s, profile routing, live subagent, delivery ledger, 1Password/Bitwarden integration; relevant to Robin's daily-driver stack; MCP 2026-07-28 revision finalization (not backward-compatible) is a related protocol-layer signal; `configuration.md` (2026-07-26) documents the iteration-budget behavior change (April 2026: removed premature 70%/90% warnings, now single wrap-up at 500/500 with grace call) and `features/api-server.md` (2026-07-27) documents new `/v1/runs/{run_id}/stop` + `/approval` endpoints with MiniMax-M3 as the documented default model; pull 7 (2026-07-30) re-anchors `api-server.md` with a new per-profile `API_SERVER_KEY` breaking-change warning and a runs API for long-form sessions, and adds a third-party Hermes Atlas "State of Hermes Agent — July 2026" report; this 2026-08-03 HN pull surfaces **Hermes Agent v0.20.0** (item `49159200`, NousResearch GitHub releases tag `v2026.8.3`, 1pt on HN day-of — the next major version after v0.19 Quicksilver); pull 11 (2026-08-03) adds a **Hermes Agent 0.19.1 GitHub bug report** (NousResearch issues/77000, 2026-08-02, score 0.790, "gpt-5.6-luna + opencode-go") confirming patch-version activity on the v0.19.x track between the v0.19 Quicksilver release and the v0.20.0 release; Tavily answer text on the Hermes/M3 lane was partially fabricated ("release date of June 1, 2026") and should be ignored — the underlying GitHub issue URL is the credible signal | 2026-07-25 | 2026-08-03 | source-backed | hackernews, web-search | 10 | active | [Tavily: Hermes v0.19 Quicksilver + MCP revision 2026-07-27](/sources/web-search.md#hermes-agent-v019-quicksilver-release--source-backed-workflow-tooling-low-priority); [Tavily: hermes-agent configuration.md + api-server.md + MyClaw 2026-07-29](/sources/web-search.md#2026-07-29-1803-pull); [Tavily: api-server.md API_SERVER_KEY break + Hermes Atlas state report 2026-07-30](/sources/web-search.md#2026-07-30-1804-pull); [Tavily: Hermes Agent 0.19.1 GitHub bug report 2026-08-03](/sources/web-search.md#2026-08-03-1808-pull); [HN: Hermes Agent v0.20.0 release 2026-08-03](/sources/hackernews.md#hermes-agent-v0200-release-refreshed-this-run) |
|
||||
| `class-organoid-3d-bioprinting` | Recurring organoid, 3D bioprinting, and 3D-cell-culture automation coverage; this window adds a 2026-07-28 HN drug-discovery essay (owlposting "Why haven't organoids solved all of drug discovery?", 9 pts), a 2026-07-27 Oxford Academic review on 3D-bioprinted organoids, a 2026-07-22 Sage review on bioprinting-enabled organoids, a 2026-07-27 Pluristyx iPSC + aerospace clinical-grade hepatocyte manufacturing partnership, the first vendor-anchored CelVivo ClinoReactor co-marketing signal (TheWell Bioscience xeno-free workflow pages), the first vendor-anchored Cellink BIO X Gen 3 / BIO X6 signal (Nuclear Mechano-Oncology install + CELLINK LinkedIn U. Miami reference + third-party market report), and the third vendor-anchored Cellink signal — **CELLINK × Volumetric new Lumen X release** (3DPrint.com 2026-07-28) — plus GEN "Large Bioprinted Tissues Get a Precision Boost" (2026-07-29) and MDPI Cells "Rapid Volumetric Bioprinting Coupled with Dynamic Perfusion Enhances Human Hepatic Organoid Toxicity Testing" (2026-07-27) on top of the prior Nature / HN evidence; pull 7 (2026-07-30) adds FDA NAMs framework (2026-07-27, organ-on-chip included among New Approach Methodologies alongside June 2026 cell/gene-therapy draft guidance), Molecular Cancer patient-derived 3D-bioprinted primary liver cancer (Peking Union Medical College Hospital, 2026-07-28), and npj Biomedical Innovations microvasculature bioprinting review (2026-07-29); pull 11 (2026-08-03) re-anchors the HepatoBiliary Surgery and Nutrition "Spatial architecture and dynamic surveillance: 3D bioprinting and microfluidics converge" review (2026-08-01) as the strongest same-week cross-anchor between organ-on-chip and 3D-bioprinting; **flywheel-sync 2026-08-08** adds 3 deep-read papers: Liu 2026 Nat Biomed Eng (shape-conformal porous framework for full-coverage neural organoid e-phys, Rogers Lab — microlattice fabrication rate 5 for Cellink, HD-MEA rate 5 for 3Brain), Miao 2025 Cell v2 (co-differentiation mesoderm+endoderm for vascularized lung/gut organoids — ClinoStar rate 5, organotypic vascularization), Sharma 2026 Cell Stem Cell (vascularized retinal organoid RGC survival — HD-MEA rate 4, CelVivo ClinoStar rate 3 for extending vascular network stability); still mostly application-domain plus three vendor-channel signals (CelVivo+TheWell; Cellink BIO X Gen 3 / BIO X6; Cellink Lumen X) + three literature flywheel-sync application-domain signals (Liu/Miao/Sharma) | 2026-07-16 | 2026-08-08 | source-backed | hackernews, web-search, literature-flywheel | 26+ | active | [HN: 49083799 drug-discovery essay 2026-07-28](/sources/hackernews.md); [Tavily: 3D bioprinted organoid reviews + Pluristyx + CelVivo+TheWell 2026-07-27](/sources/web-search.md#2026-07-27-1804-pull); [Tavily: Cellink BIO X Gen 3 / BIO X6 + CN Bio / NASA AVATAR OOC + GEN bioprinting 2026-07-29](/sources/web-search.md#2026-07-29-1803-pull); [Tavily: FDA NAMs + Peking Union 3D-bioprinted liver cancer + npj microvasculature 2026-07-30](/sources/web-search.md#2026-07-30-1804-pull); [Tavily: Cellink × Volumetric new Lumen X + 3Brain Utrecht Summer School + CelVivo ClinoStar 2 / Thailand Lab 2026 + HBSN bioprinting+microfluidics 2026-08-03](/sources/web-search.md#2026-08-03-1808-pull); [Flywheel: Liu 2026 NBME shape-conformal framework + Miao 2025 Cell v2 vascularized organoids + Sharma 2026 Cell Stem Cell vascularized retinal organoids 2026-08-08](/sources/literature.md) |
|
||||
| `china-cde-cell-gene-therapy-rules-2026` | China CDE (under NMPA) published technical guidelines defining scope & classification of cell and gene therapy drugs; standardizes CMC planning for Chinese pharma/CDMO/biotech customers | 2026-07-24 | 2026-07-24 | source-backed | web-search | 1 | watchlist | [Tavily: cisema.com 2026-07-24](/sources/web-search.md) |
|
||||
| `china-order-no-818-clinical-translation` | China's Order No. 818 (effective 2026-05-01) creates an accelerated pathway for advanced biomedical technologies — including cell therapy and 3D bioprinting — towards regulated clinical translation at qualified hospitals after demonstrating safety and preliminary efficacy; the clinical-translation counterpart to the CDE classification item and directly relevant to Robin's Chinese pharma R&D / CDMO / biotech customer base | 2026-07-28 | 2026-07-28 | source-backed | web-search | 1 (+ Tavily synthesis) | watchlist | [Tavily: BetaLife LinkedIn 2026-07 + Roots Analysis re-mention 2026-07-28](/sources/web-search.md) |
|
||||
| `MiniMax-m3` | MiniMax-M3 (1M context multimodal) HuggingFace model card + Twitter launch; the daily-driver inference provider behind every OpenWiki run and most of Robin's agent work; haimaker.ai July 2026 third-party eval ranks models for Hermes Agent usage; MyClaw.ai 2026-07-29 confirms M3 + M2.7 are the operational models for both OpenClaw and Hermes, with M3 supporting multimodal (image, video, music, speech, web search); pull 11 (2026-08-03) adds **unsloth/MiniMax-M3-GGUF** (HuggingFace 2026-08-01) confirming quantized local-LLM run path + **benchlm.ai "DeepSeek V4 Flash vs MiniMax M3: Benchmarks & Cost"** (2026-08-01) reframing M3 as "1M context window at $0.30…"; this 2026-08-03 HN pull surfaces the **MiniMax-H3 launch cluster** (item `49155629` 167pts top-feed ComfyUI Day-0 support with open weights + native audio + 2K video; item `49150583` 8pts "MiniMax-H3 weights are up" on HuggingFace model card; item `49150861` 2pts "Run MiniMax-H3 Locally with SGLang Diffusion on 2× RTX 5090s or 1× RTX Pro 6000" via LMSYS Twitter) — three distinct primary sources on the same day confirming H3 as the next frontier model release after M3 | 2026-07-16 | 2026-08-03 | source-backed | hackernews, web-search | 8+ | active | [HN: M3 model cluster + H3 launch cluster 2026-08-03](/sources/hackernews.md); [Tavily: Hermes Agent best-models eval](/sources/web-search.md); [Tavily: MyClaw OpenClaw vs MiniMax Agent 2026-07-29](/sources/web-search.md#2026-07-29-1803-pull); [Tavily: unsloth/MiniMax-M3-GGUF + BenchLM M3 vs DeepSeek V4 Flash 2026-08-03](/sources/web-search.md#2026-08-03-1808-pull) |
|
||||
| `hermes-agent-v0-19-quicksilver` | Hermes Agent v0.19 "Quicksilver" release (2026-07-25): first-token delay 4.3s → 0.9s, profile routing, live subagent, delivery ledger, 1Password/Bitwarden integration; relevant to Robin's daily-driver stack; MCP 2026-07-28 revision finalization (not backward-compatible) is a related protocol-layer signal; `configuration.md` (2026-07-26) documents the iteration-budget behavior change (April 2026: removed premature 70%/90% warnings, now single wrap-up at 500/500 with grace call) and `features/api-server.md` (2026-07-27) documents new `/v1/runs/{run_id}/stop` + `/approval` endpoints with MiniMax-M3 as the documented default model; pull 7 (2026-07-30) re-anchors `api-server.md` with a new per-profile `API_SERVER_KEY` breaking-change warning and a runs API for long-form sessions, and adds a third-party Hermes Atlas "State of Hermes Agent — July 2026" report; this 2026-08-03 HN pull surfaces **Hermes Agent v0.20.0** (item `49159200`, NousResearch GitHub releases tag `v2026.8.3`, 1pt on HN day-of — the next major version after v0.19 Quicksilver); pull 11 (2026-08-03) adds a **Hermes Agent 0.19.1 GitHub bug report** (NousResearch issues/77000, 2026-08-02, score 0.790, "gpt-5.6-luna + opencode-go") confirming patch-version activity on the v0.19.x track between the v0.19 Quicksilver release and the v0.20.0 release; Tavily answer text on the Hermes/M3 lane was partially fabricated ("release date of June 1, 2026") and should be ignored — the underlying GitHub issue URL is the credible signal | 2026-07-25 | 2026-08-03 | source-backed | hackernews, web-search | 10 | active | [Tavily: Hermes v0.19 Quicksilver + MCP revision 2026-07-27](/sources/web-search.md); [Tavily: hermes-agent configuration.md + api-server.md + MyClaw 2026-07-29](/sources/web-search.md#2026-07-29-1803-pull); [Tavily: api-server.md API_SERVER_KEY break + Hermes Atlas state report 2026-07-30](/sources/web-search.md#2026-07-30-1804-pull); [Tavily: Hermes Agent 0.19.1 GitHub bug report 2026-08-03](/sources/web-search.md#2026-08-03-1808-pull); [HN: Hermes Agent v0.20.0 release 2026-08-03](/sources/hackernews.md) |
|
||||
| `openwiki-brand` | `langchain-ai/openwiki` (96 pts) — same product family as Robin's OpenWiki; high-engagement on HN | 2026-07-16 | 2026-07-16 | source-backed | hackernews | 1 (+ 2 adjacent wrappers) | watchlist | [HN: openwiki cluster](/sources/hackernews.md#openwiki-brand-signal) |
|
||||
| `agent-memory-architecture` | Shared agent-memory architecture using Karpathy's LLM Wiki + Google's Open Knowledge Format (OKF) + MCP — let "every Local AI share ONE permanent memory"; this 2026-07-29 Tavily pull adds four more corroborated sources (Hackernoon Moorcheh.ai "Agent Memory Has a Lock-In Problem. Open Formats Are How We Fix It." with diffability / reviewability / auditability framing; Towards Data Science "Usage-Reinforced Decay Engine for AI Agent Memory" using Ebbinghaus forgetting curve; The Register / MinIO AIStor Memory for long-running multi-step workflows; HPCwire Exabase M-1 BEAM benchmark numbers 76.9% / 75.0% / 68.0% at 100K/1M/10M tokens) on top of the prior HN + Tavily sources; the Hackernoon piece is the strongest OpenWiki-aligning source yet; pull 7 (2026-07-30) adds arXiv 2607.24759v1 "A Templated Substrate for Heterogeneous Collaborative" + rohitg00 LLM Wiki v2 (extending Karpathy's LLM Wiki pattern with lessons from building agentmemory) + Pi `@zosmaai/pi-llm-wiki` package + MinIO AIStor Memory (HPCwire 2026-07-29 + SiliconANGLE 2026-07-30); pull 11 (2026-08-03) adds **akitaonrails/ai-memory `docs/research-karpathy-llm-wiki.md`** (GitHub 2026-07-28, score 0.601) — a third-party research write-up of the Karpathy LLM Wiki pattern — bringing the cluster to 15+ distinct sources | 2026-07-26 | 2026-08-03 | source-backed | hackernews, web-search | 15+ | active | [HN: 49059959, 49059889, 49060215](/sources/hackernews.md#agent-memory-architecture-watchlist--new); [Tavily: LLM Wiki + OKF cluster 2026-07-28](/sources/web-search.md#llm-wiki--okf--shared-agent-memory-cluster--source-backed-workflow-tooling-low-priority); [Tavily: Moorcheh.ai + TDS + MinIO + Exabase cluster 2026-07-29](/sources/web-search.md#2026-07-29-1803-pull); [Tavily: arXiv 2607.24759v1 + LLM Wiki v2 + Pi pi-llm-wiki + MinIO AIStor 2026-07-30](/sources/web-search.md#2026-07-30-1804-pull); [Tavily: akitaonrails/ai-memory research write-up 2026-08-03](/sources/web-search.md#2026-08-03-1808-pull) |
|
||||
| `agent-memory-architecture` | Shared agent-memory architecture using Karpathy's LLM Wiki + Google's Open Knowledge Format (OKF) + MCP — let "every Local AI share ONE permanent memory"; this 2026-07-29 Tavily pull adds four more corroborated sources (Hackernoon Moorcheh.ai "Agent Memory Has a Lock-In Problem. Open Formats Are How We Fix It." with diffability / reviewability / auditability framing; Towards Data Science "Usage-Reinforced Decay Engine for AI Agent Memory" using Ebbinghaus forgetting curve; The Register / MinIO AIStor Memory for long-running multi-step workflows; HPCwire Exabase M-1 BEAM benchmark numbers 76.9% / 75.0% / 68.0% at 100K/1M/10M tokens) on top of the prior HN + Tavily sources; the Hackernoon piece is the strongest OpenWiki-aligning source yet; pull 7 (2026-07-30) adds arXiv 2607.24759v1 "A Templated Substrate for Heterogeneous Collaborative" + rohitg00 LLM Wiki v2 (extending Karpathy's LLM Wiki pattern with lessons from building agentmemory) + Pi `@zosmaai/pi-llm-wiki` package + MinIO AIStor Memory (HPCwire 2026-07-29 + SiliconANGLE 2026-07-30); pull 11 (2026-08-03) adds **akitaonrails/ai-memory `docs/research-karpathy-llm-wiki.md`** (GitHub 2026-07-28, score 0.601) — a third-party research write-up of the Karpathy LLM Wiki pattern — bringing the cluster to 15+ distinct sources | 2026-07-26 | 2026-08-03 | source-backed | hackernews, web-search | 15+ | active | [HN: 49059959, 49059889, 49060215](/sources/hackernews.md); [Tavily: LLM Wiki + OKF cluster 2026-07-28](/sources/web-search.md); [Tavily: Moorcheh.ai + TDS + MinIO + Exabase cluster 2026-07-29](/sources/web-search.md#2026-07-29-1803-pull); [Tavily: arXiv 2607.24759v1 + LLM Wiki v2 + Pi pi-llm-wiki + MinIO AIStor 2026-07-30](/sources/web-search.md#2026-07-30-1804-pull); [Tavily: akitaonrails/ai-memory research write-up 2026-08-03](/sources/web-search.md#2026-08-03-1808-pull) |
|
||||
|
||||
## Notes
|
||||
|
||||
|
||||
@@ -59,6 +59,8 @@ The state diagram shows the canonical CelVivo → 3Brain workflow: 3D suspension
|
||||
|
||||
- **Whitepaper: "Breaking the Bias" (2026, 16 pp)** — CelVivo's official vendor narrative on brain organoid long-term culture. Key data: ~110 day / 8 mm diameter brain organoid (Univ. Groningen, Trombetta-Lima); sc-RNA-seq 17,738 cells at Day 90 (Univ. Lausanne, Bagni); Day 30/45 dorsal forebrain comparison vs orbital shaker (Drexel, Qiang); hiPSC → cortical organoid + Omicron BA.5 (QIMR Berghofer, Stewart 2022). 4 patents: WO 2021/001472, WO 2021/245117, WO 2022/008292, WO 2022/144461. Full synthesis at [`/sources/literature-celvivo-brain-whitepaper-2026.md`](/sources/literature-celvivo-brain-whitepaper-2026.md).
|
||||
- **Bosnjakovic 2025 bioRxiv (PAH HepG2 3D spheroid, ClinoStar dynamic culture)** — 21-day maturation + 24h/96h BaP/BBF exposure; **4 metabolic markers (phenylalanine, TCA intermediates, GSH depletion, sphingolipid dysregulation) only appear in 3D, completely invisible in 2D**. Sales ammunition: "your 2D model is missing 100% of environmental toxicology early signals". Synthesis at [`/sources/literature-cel-bosnjakovic-2025-pah-deepread.md`](/sources/literature-cel-bosnjakovic-2025-pah-deepread.md).
|
||||
- **Miao 2025 Cell v2 (co-differentiation mesoderm + endoderm, vascularized lung/gut organoids, ClinoStar rotating culture)** — single 3D EB co-induction strategy yields **vHLPO with 7% ECs vs traditional HLPO 0%**, organ-specific endothelium + mesenchyme scRNA-seq validation, in-vivo functional integration with host circulation, FOXF1 mutation ACDMPV dual-pathology disease modeling. Product relevance: CelVivo ClinoStar rating 5 (co-differentiation depends on 3D EB self-organization in low-shear rotating culture — ClinoStar is the canonical hardware), HD-MEA rating 4, 3D bioprinting rating 3, patient-derived organoid drug screening rating 5. Synthesis at [`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`](/sources/literature-miao-2025-cell-vascularization-v2-deepread.md).
|
||||
- **Liu 2026 Nat Biomed Eng (shape-conformal porous framework for neural organoid e-phys, Rogers Lab)** — CelVivo ClinoStar rating 4 (organoid culture downstream of the shape-conformal framework; long-term maturation + functional readout is the canonical ClinoStar → HD-MEA workflow). Synthesis at [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md). See 3Brain evidence for the HD-MEA read side.
|
||||
- **Sales ammunition kit (CelVivo pricing + 8 Protocols + 5 app notes + 5 brand/whitepapers)** — Demo kit `10005-6` lists at €300 (Global Distributor Price, with special discount). 8 ClinoReactor Protocols cover prepare / media change / gardening / plate config / rotation-speed / alginate embed / VitroGel embed. 5 application notes cover HepG2/C3A liver, FTC-133 thyroid, NCI-H69V SCLC, TNBC, ClinoStar vs Orbital Shaker. Synthesis at [`/sources/sales-ammunition.md`](/sources/sales-ammunition.md).
|
||||
- **260528_CS vs OS app note (2026-07-17 deep read)** — ClinoStar vs Orbital Shaker shear-stress comparison for long-term 3D construct performance; ClinoStar has lower shear + long-term growth + better consistency. This is the **vs-competitor killer document** for "why not use an orbital shaker" customer questions.
|
||||
- **111_Planimetry app note (2026-07-17 deep read)** — Planimetry measurements of spheroids in ClinoReactor using FIJI (open-source). Standard answer for "how to quantify spheroids".
|
||||
@@ -66,6 +68,8 @@ The state diagram shows the canonical CelVivo → 3Brain workflow: 3D suspension
|
||||
### 3Brain evidence
|
||||
|
||||
- **Raji 2026 Mol Psychiatry (hMOs + 3Brain HD-MEA, 2026-07-27 deep read)** — WNT-modulated human midbrain organoids + 3Brain BioCAM DupleX + Accura-3D (4096 electrodes) + BrainWave 5. **TH+ 58% at 12 weeks** (vs 2D 18%, 3D static 32%). DA release 76 pg/mL (vs 2D 12, 3D static 28). α-synuclein PFF → DA neurons -35% / TH -40% / DA release -45% — establishes the **PD drug screening platform**. Shear-stress 15x lower than orbital shaking (0.13 dyn/cm² vs 2.03 dyn/cm²). Synthesis at [`/sources/literature-raji-2026-deepread.md`](/sources/literature-raji-2026-deepread.md).
|
||||
- **Liu 2026 Nat Biomed Eng (shape-conformal porous framework, full-coverage neural organoid e-phys, Rogers Lab)** — HD-MEA rating 5: **3000-8000 channels per organoid vs traditional MEA 200-1000 (10-50× improvement), >90% surface coverage vs 5-15%, weeks-long stable recording + bi-directional electrical + optogenetic stimulation, epilepsy + AD disease modeling**. The framework is the **direct next-generation design reference** for 3Brain's current 4096-electrode Accura-3D; Robin should sell Accura-3D as the existing best-in-class and Liu 2026 as the forward-looking 3D-coverage direction. Synthesis at [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md). Tracks as `liu-2026-hd-mea-roadmap-implication` commitment (verify with 3Brain whether flexible-electronics / shape-conformal framework is on their roadmap).
|
||||
- **Sharma 2026 Cell Stem Cell (vascularized retinal organoids, RGC survival)** — HD-MEA rating 4: paper uses 60-channel MCS MEA2100-Lite; 3Brain HD-MEA is same-generation HD technology, technical route is transferable. The W31 ON/OFF/ON-OFF light-response recording paradigm is the kind of long-duration, multi-class recording where HD spatial resolution matters most. CelVivo ClinoStar rating 3 (vascular network regresses in static culture → ClinoStar low-shear route candidate). W18 RGC yield **18.2% vs ctrl-RO 1.21% (15× improvement)** through C3 endothelial monolayer integration. Synthesis at [`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`](/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md).
|
||||
- **3Brain Sample Holder Set / PressNet (UK GB2624872)** — Mechanical net-press device for CorePlate 1W/6W; load force 250–1250 µN. Recorded 2026-07-07 (untracked in vault). Carryover evidence in [`/sources/git-repo.md`](/sources/git-repo.md) Notable entities.
|
||||
- **3Brain end-customer dossiers** — 11+ dossiers under `03-Resources/End-Customers/` covering 神经所 (上海), 北京大学, 北京天坛医院, 浙大一附院, 中科院昆明动物所, 西南医科大学, 贵州医科大学, plus TCM accounts at 云南中医药大学 and 天津创新中药. Listed in [`/sources/git-repo.md`](/sources/git-repo.md) Notable entities.
|
||||
- **Vendor-channel strand (Tavily 2026-07-30 → 2026-08-03)** — 3Brain's official website + LinkedIn (booth 412 at ISSCR 2026; booth 4 at ELRIG Drug Discovery; Utrecht Summer School "Human Brain Models" course 2026-07-29). Tracks in `/commitments.md` as `3brain-coreplate-2026-conference-positioning` (verify which conference posts are current and pull application notes).
|
||||
@@ -73,6 +77,8 @@ The state diagram shows the canonical CelVivo → 3Brain workflow: 3D suspension
|
||||
## Cross-vendor workflow links
|
||||
|
||||
- **CelVivo + 3Brain joint workflow** (from Raji 2026): hMOs are cultured in a **bioreactor** (CelVivo-class, low-shear rotating-wall) for 12 weeks; transplanted to **3Brain Accura-3D** (4096-electrode HD-MEA chip) for 24h spike-train recording via BrainWave 5. Two pieces of hardware from two vendors compose the **PD drug screening platform** Robin sells.
|
||||
- **CelVivo + 3Brain next-gen workflow** (from Liu 2026): the shape-conformal porous framework (Rogers Lab, next-gen HD-MEA design) records 3000-8000 channels per organoid vs current 4096 — **forward-looking direction** for the CelVivo → 3Brain pipeline. Track in `/commitments.md` as `liu-2026-hd-mea-roadmap-implication`.
|
||||
- **CelVivo + 3Brain vascularized organoid workflow** (from Miao 2025 v2 + Sharma 2026): vHLPO and vRO use single 3D EB co-induction (mesoderm+endoderm) or C3 endothelial monolayer integration. The vascular-like networks regress in static culture — **CelVivo ClinoStar low-shear rotating culture is the candidate route to extend maturation**. Functional readout remains 3Brain HD-MEA territory (60-channel MEA in Sharma; future HD-MEA for vascularized organoids).
|
||||
- **CelVivo + TheWell Bioscience xeno-free workflow** (Tavily 2026-07-21/23/25): TheWell's hydrogel-media workflow pages position **ClinoReactor as the scale-up vessel for apical-out organoids + hMSC expansion**. Tracks in `/commitments.md` as `celvivo-clinoreactor-thewell-bioscience-xeno-free` (verify whether sanctioned co-marketing).
|
||||
- **CelVivo + Femtobiomed** (small but complementary): Femtobiomed CellShot / CellPick / TriArm for hiPSC electroporation upstream of CelVivo 3D culture.
|
||||
|
||||
@@ -101,6 +107,9 @@ The state diagram shows the canonical CelVivo → 3Brain workflow: 3D suspension
|
||||
| What is ClinoReactor's pricing? | [`/sources/sales-ammunition.md`](/sources/sales-ammunition.md) |
|
||||
| What does the CelVivo brain organoid whitepaper actually say? | [`/sources/literature-celvivo-brain-whitepaper-2026.md`](/sources/literature-celvivo-brain-whitepaper-2026.md) |
|
||||
| What is Raji 2026's PD drug screening story? | [`/sources/literature-raji-2026-deepread.md`](/sources/literature-raji-2026-deepread.md) |
|
||||
| What is Miao 2025's vascularized lung/gut organoid story? | [`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`](/sources/literature-miao-2025-cell-vascularization-v2-deepread.md) |
|
||||
| What is Liu 2026's shape-conformal neural organoid e-phys story? | [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md) |
|
||||
| What is Sharma 2026's vascularized retinal organoid RGC story? | [`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`](/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md) |
|
||||
| What distributors am I actually working with? | [`/sources/agents.md`](/sources/agents.md) |
|
||||
| Which Chinese dealers carry our brand? | [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) |
|
||||
| What regulatory shifts affect our Chinese pharma deals? | [`/commitments.md`](/commitments.md) China CDE / Order No. 818 / China CGT items |
|
||||
|
||||
@@ -48,6 +48,7 @@ This is the synthesis page for **3D 生物打印** — Robin's 3D bioprinting pr
|
||||
|
||||
The 3D bioprinting lane also captures application-domain papers that bioprint scaffolds for organoid culture — these are **vendor-adjacent** signals that fold into the [`/themes/01-organoid-equipment.md`](/themes/01-organoid-equipment.md) organoid culture theme rather than into Cellink hardware sales:
|
||||
|
||||
- **Liu 2026 Nat Biomed Eng (shape-conformal porous framework, Rogers Lab, 2026-08-08 deep read)** — flexible-electronics microlattice fabrication as a 3D-bioprinting-adjacent technology for neural organoid scaffolds. **3D bioprinting rating 5** — the microlattice fabrication technique depends on 3D printing-class resolution (Cellink BIO X / BIONOVA X / Lumen X cannot directly print at this resolution today, but the field direction is clear: future bioprinters will integrate flexible-electronics fabrication). The framework records 3000-8000 channels per organoid (>90% surface coverage, weeks-long stable recording, epilepsy + AD disease modeling) — Robin should pitch Liu 2026 to Cellink to understand whether BIONOVA X or Lumen X can fabricate flexible-electronics-compatible microlattices. Synthesis at [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md). First entry in the new NocoDB table `Robin_Picked_Papers` (created 2026-08-08).
|
||||
- **MDPI Cells 2026-07-27** — "Rapid Volumetric Bioprinting Coupled with Dynamic Perfusion Enhances Human Hepatic Organoid Toxicity Testing"
|
||||
- **GEN 2026-07-29** — "Large Bioprinted Tissues Get a Precision Boost"
|
||||
- **HepatoBiliary Surgery and Nutrition 2026-08-01** — "Spatial architecture and dynamic surveillance: 3D bioprinting and microfluidics converge" (strongest same-week cross-anchor between organ-on-chip and 3D-bioprinting)
|
||||
@@ -95,3 +96,4 @@ The bioprinting theme is **evidence-light compared to theme 1 (organoid-equipmen
|
||||
| Are there BIO X Gen 3 / BIO X6 customer installs in China? | [`/commitments.md`](/commitments.md) `cellink-bio-x-gen3-customer-evidence` |
|
||||
| What distributors carry Cellink in China? | [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) |
|
||||
| What 3D bioprinted-organoid reviews have come out this month? | [`/sources/web-search.md`](/sources/web-search.md) 2026-07-29 / 2026-07-30 / 2026-08-03 pulls |
|
||||
| What is Liu 2026's shape-conformal neural organoid framework story (microlattice + flexible electronics)? | [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md) |
|
||||
+14
-19
@@ -19,30 +19,29 @@ This is the synthesis page for **AI Agent 工具** — Robin's daily-driver stac
|
||||
|
||||
## Agent stack architecture
|
||||
|
||||
<!-- openwiki: mermaid parse failed and this diagram was converted to a text fence so it does not break rendering. Fix the diagram source and restore the mermaid fence. Parser error: Heuristic: an unescaped angle bracket inside a label breaks rendering; rephrase the label. -->
|
||||
```text
|
||||
```mermaid
|
||||
flowchart TD
|
||||
User[Robin · desktop / mobile]
|
||||
subgraph DesktopWSL[WSL · primary host]
|
||||
Hermes[Hermes Agent v0.19 Quicksilver]
|
||||
Cron1["cron 02:00<br/>openwiki-update.sh"]
|
||||
Cron1["cron 02:00 (openwiki-update.sh)"]
|
||||
end
|
||||
subgraph DesktopPC[Windows desktop · secondary]
|
||||
MiniMaxCode[MiniMax code<br/>+ 4 bridge skills]
|
||||
MiniMaxCode["MiniMax code (+ 4 bridge skills)"]
|
||||
CodexCLI[Codex CLI fallback]
|
||||
end
|
||||
subgraph Remote[ITX 24h host · future]
|
||||
ITXHermes[Hermes Agent<br/>on Ubuntu 22.04]
|
||||
ITXHermes["Hermes Agent (on Ubuntu 22.04)"]
|
||||
end
|
||||
subgraph Memory[Memory substrate]
|
||||
OpenWiki[(OpenWiki<br/>local markdown wiki)]
|
||||
Gitea[Gitea public mirror<br/>10.10.10.254:3080]
|
||||
OpenWiki[("OpenWiki (local markdown wiki)")]
|
||||
Gitea["Gitea public mirror (10.10.10.254:3080)"]
|
||||
end
|
||||
subgraph KB[Knowledge backends · NAS]
|
||||
RAGFlowKB[RAGFlow<br/>18 KB · 32709 docs]
|
||||
NocoDBDB[NocoDB<br/>13 lit tables]
|
||||
SeaFileStore[SeaFile<br/>4 repos · 77 GB]
|
||||
WikiJS[Wiki.js<br/>1500+ pages]
|
||||
RAGFlowKB["RAGFlow (18 KB · 32709 docs)"]
|
||||
NocoDBDB["NocoDB (13 lit tables)"]
|
||||
SeaFileStore["SeaFile (4 repos · 77 GB)"]
|
||||
WikiJS["Wiki.js (1500+ pages)"]
|
||||
end
|
||||
subgraph LLM[Local inference · see theme 04]
|
||||
MiniMaxM3[MiniMax-M3 1M context]
|
||||
@@ -96,8 +95,7 @@ The architecture shows three agent surfaces sharing the OpenWiki memory substrat
|
||||
- **OpenWiki = LangChain 7/10 open-source "personal brain" framework.** Local markdown wiki rooted at `~/.openwiki/wiki`, mirrored to Gitea public `http://10.10.10.254:3080/Robin/openwiki-wiki`. Cron pipeline: every night 02:00 `openwiki-update.sh` (HN + Tavily + git-repo + M3 agent synthesis) → commit → push to Gitea. Every 02:30 `openwiki-update-sources.sh` (NocoDB + SeaFile + Wiki.js + RAGFlow health checks) → commit → push.
|
||||
- **Five canonical synthesis pages** — [`/quickstart.md`](/quickstart.md), [`/themes.md`](/themes.md), [`/commitments.md`](/commitments.md), [`/open-questions.md`](/open-questions.md), [`/personal-logistics.md`](/personal-logistics.md). Five detailed theme pages under [`/themes/`](/themes/).
|
||||
- **Evidence layer** — 21 source pages under [`/sources/`](/sources/), one per active connector or subsystem.
|
||||
<!-- openwiki: broken internal link [/sources/README-ACTIVATION.md] file "/sources/README-ACTIVATION.md" does not exist. Fix the href or restore the target, then delete this comment. -->
|
||||
- **Activation manual:** [`/sources/README-ACTIVATION.md`](/sources/README-ACTIVATION.md) (2026-07-27 update). 8 sections covering TL;DR / connectors not yet on / daily operations / what Robin manually does / what Robin never touches / cross-tool cheat sheet / today's real system status / changes from 7-26 / next steps.
|
||||
- **Activation manual:** [`/README-ACTIVATION.md`](/README-ACTIVATION.md) (2026-07-27 update). 8 sections covering TL;DR / connectors not yet on / daily operations / what Robin manually does / what Robin never touches / cross-tool cheat sheet / today's real system status / changes from 7-26 / next steps.
|
||||
- **Cheat sheet:** [`/sources/OpenWiki速查手册.md`](/sources/OpenWiki速查手册.md) (2026-07-27 one-shot reference for talking to colleagues / boss / agents about what OpenWiki is).
|
||||
|
||||
## Supporting toolchain (AI-side)
|
||||
@@ -106,8 +104,7 @@ The architecture shows three agent surfaces sharing the OpenWiki memory substrat
|
||||
|
||||
- **Master template:** [`/sources/ldr-report-template.md`](/sources/ldr-report-template.md) — 8 铁律 + 3 trigger modes (精简 4 步 vs 完整 8 步 vs 自动) + 5-section report template (做什么 / 3 发现 / 4 维产品对接 / 局限 / 转发语+落款+PDF). Total report length 800–1500 characters.
|
||||
- **SOP lessons:** [`/sources/2026-07-27-4-27-sop-vs-implementation.md`](/sources/2026-07-27-4-27-sop-vs-implementation.md) — 9-step SOP vs 7-27 凭印象实操 comparison. PyMuPDF xref dedup + 30KB filter + p1 logo 剔除. NocoDB v1 + JSON body (范本 v2 fails 3x). SeaFile `?dl=1` suffix required. 3-frame SeaFile image 嵌入 markdown.
|
||||
<!-- openwiki: broken internal link [/sources/memory-2026-07-16-tools-final.md] file "/sources/memory-2026-07-16-tools-final.md" does not exist. Fix the href or restore the target, then delete this comment. -->
|
||||
- **Toolchain打通战报:** [`/sources/memory-2026-07-16-tools-final.md`](/sources/memory-2026-07-16-tools-final.md) — 2026-07-16 OpenWiki + Gitea + NocoDB + RAGFlow + Wiki.js + MiniMax code 端到端打通. 9 链路.
|
||||
- **Toolchain打通战报:** [`/memory-2026-07-16-tools-final.md`](/memory-2026-07-16-tools-final.md) — 2026-07-16 OpenWiki + Gitea + NocoDB + RAGFlow + Wiki.js + MiniMax code 端到端打通. 9 链路.
|
||||
|
||||
### Remote access (RustDesk)
|
||||
|
||||
@@ -141,11 +138,9 @@ The architecture shows three agent surfaces sharing the OpenWiki memory substrat
|
||||
| Question | Go to |
|
||||
| --- | --- |
|
||||
| What is OpenWiki and how do I use it? | [`/sources/OpenWiki速查手册.md`](/sources/OpenWiki速查手册.md) |
|
||||
<!-- openwiki: broken internal link [/sources/README-ACTIVATION.md] file "/sources/README-ACTIVATION.md" does not exist. Fix the href or restore the target, then delete this comment. -->
|
||||
| What connectors does OpenWiki have? | [`/sources/README-ACTIVATION.md`](/sources/README-ACTIVATION.md) |
|
||||
| What connectors does OpenWiki have? | [`/README-ACTIVATION.md`](/README-ACTIVATION.md) |
|
||||
| What is the LDR report format? | [`/sources/ldr-report-template.md`](/sources/ldr-report-template.md) |
|
||||
| What are the LDR SOP lessons? | [`/sources/2026-07-27-4-27-sop-vs-implementation.md`](/sources/2026-07-27-4-27-sop-vs-implementation.md) |
|
||||
| How is RustDesk configured? | [`/sources/rustdesk-sop.md`](/sources/rustdesk-sop.md) |
|
||||
<!-- openwiki: broken internal link [/sources/memory-2026-07-16-tools-final.md] file "/sources/memory-2026-07-16-tools-final.md" does not exist. Fix the href or restore the target, then delete this comment. -->
|
||||
| What did Robin do on 2026-07-16 (toolchain通)? | [`/sources/memory-2026-07-16-tools-final.md`](/sources/memory-2026-07-16-tools-final.md) |
|
||||
| What did Robin do on 2026-07-16 (toolchain通)? | [`/memory-2026-07-16-tools-final.md`](/memory-2026-07-16-tools-final.md) |
|
||||
| What is the ITX 24h host build? | [`/commitments.md`](/commitments.md) `itx-24h-host-build-2026-q3` |
|
||||
+21
-23
@@ -19,31 +19,30 @@ This is the synthesis page for **本地大模型部署** — Robin's local infer
|
||||
|
||||
## Local-LLM fleet architecture
|
||||
|
||||
<!-- openwiki: mermaid parse failed and this diagram was converted to a text fence so it does not break rendering. Fix the diagram source and restore the mermaid fence. Parser error: Heuristic: an unescaped angle bracket inside a label breaks rendering; rephrase the label. -->
|
||||
```text
|
||||
```mermaid
|
||||
flowchart TD
|
||||
subgraph Desktop["Desktop · 192.168.192.67"]
|
||||
OllamaServe["Ollama serve<br/>:11434"]
|
||||
QwenV["qwen2.5vl:7b<br/>(vision)"]
|
||||
NomicE["nomic-embed-text<br/>(embed)"]
|
||||
LMStudio["LM Studio<br/>:7997"]
|
||||
BgeM3LM["BAAI/bge-m3<br/>(embed via LM Studio)"]
|
||||
Reranker["bge-reranker<br/>:8090"]
|
||||
OllamaServe["Ollama serve :11434"]
|
||||
QwenV["qwen2.5vl:7b (vision)"]
|
||||
NomicE["nomic-embed-text (embed)"]
|
||||
LMStudio["LM Studio :7997"]
|
||||
BgeM3LM["BAAI/bge-m3 (embed via LM Studio)"]
|
||||
Reranker["bge-reranker :8090"]
|
||||
OllamaServe --> QwenV
|
||||
OllamaServe --> NomicE
|
||||
LMStudio --> BgeM3LM
|
||||
end
|
||||
subgraph NAS["NAS · 10.10.10.254"]
|
||||
RAGFlow["RAGFlow KB<br/>:9980<br/>18 KB / 32,709 docs"]
|
||||
NocoDB["NocoDB<br/>:8081<br/>13 lit tables"]
|
||||
SeaFile["SeaFile<br/>:9898<br/>4 repos / 77 GB"]
|
||||
WikiJS["Wiki.js<br/>:3000<br/>~1500 pages"]
|
||||
Feishu["Feishu mail<br/>IMAP poll (awaiting creds)"]
|
||||
RAGFlow["RAGFlow KB :9980 (18 KB / 32,709 docs)"]
|
||||
NocoDB["NocoDB :8081 (13 lit tables)"]
|
||||
SeaFile["SeaFile :9898 (4 repos / 77 GB)"]
|
||||
WikiJS["Wiki.js :3000 (~1500 pages)"]
|
||||
Feishu["Feishu mail IMAP poll (awaiting creds)"]
|
||||
end
|
||||
subgraph Agents["Agents (see theme 03)"]
|
||||
Hermes[Hermes Agent]
|
||||
MiniMaxCode[MiniMax code]
|
||||
CronDaily["cron 02:30<br/>update-sources.sh"]
|
||||
CronDaily["cron 02:30 update-sources.sh"]
|
||||
end
|
||||
|
||||
RAGFlow -.embedding.-> OllamaServe
|
||||
@@ -59,7 +58,7 @@ flowchart TD
|
||||
CronDaily -->|count refresh| NocoDB
|
||||
CronDaily -->|count refresh| SeaFile
|
||||
CronDaily -->|count refresh| WikiJS
|
||||
QwenV -.vision OCR.-> LDR["LDR SOP<br/>(theme 05)"]
|
||||
QwenV -.vision OCR.-> LDR["LDR SOP (theme 05)"]
|
||||
```
|
||||
|
||||
The diagram shows the three local inference services (Ollama serve, LM Studio, bge-reranker) feeding the RAGFlow KB layer, with the four NAS subsystems (NocoDB / SeaFile / Wiki.js / Feishu mail) attached at the metadata / file / published-deep-read / IMAP layer. All three inference services and all four subsystems are probed nightly by `update-sources.sh` at 02:30.
|
||||
@@ -147,14 +146,13 @@ Each subsystem has its own source page; the bullets below are the cross-agent qu
|
||||
|
||||
Two cron pipelines drive the local-LLM fleet:
|
||||
|
||||
<!-- openwiki: mermaid parse failed and this diagram was converted to a text fence so it does not break rendering. Fix the diagram source and restore the mermaid fence. Parser error: Heuristic: an unescaped angle bracket inside a label breaks rendering; rephrase the label. -->
|
||||
```text
|
||||
```mermaid
|
||||
flowchart LR
|
||||
subgraph Cron1["02:00 daily · openwiki-update.sh"]
|
||||
HN[Hacker News ingest]
|
||||
Tavily[Tavily web search ingest]
|
||||
GitRepo[git-repo ingest]
|
||||
M3["M3 agent synthesis<br/>writes /themes + /commitments"]
|
||||
M3["M3 agent synthesis (writes /themes + /commitments)"]
|
||||
end
|
||||
subgraph Cron2["02:30 daily · openwiki-update-sources.sh"]
|
||||
NocoDBP[NocoDB count refresh]
|
||||
@@ -166,12 +164,12 @@ flowchart LR
|
||||
FeishuP[Feishu INBOX poll]
|
||||
end
|
||||
subgraph Runtime["Local inference runtime"]
|
||||
OllamaEmbed["Ollama :11434<br/>nomic-embed-text"]
|
||||
LMStudioEmbed["LM Studio :7997<br/>BAAI/bge-m3"]
|
||||
OllamaEmbed["Ollama :11434 (nomic-embed-text)"]
|
||||
LMStudioEmbed["LM Studio :7997 (BAAI/bge-m3)"]
|
||||
RerankerSvc["bge-reranker :8090"]
|
||||
end
|
||||
subgraph Sink["Wiki sink"]
|
||||
OpenWiki[OpenWiki<br/>commit and push Gitea]
|
||||
OpenWiki[OpenWiki (commit and push Gitea)]
|
||||
end
|
||||
Cron1 --> OpenWiki
|
||||
Cron2 --> OpenWiki
|
||||
@@ -213,7 +211,7 @@ The 02:00 cron pulls 3 connectors and runs M3 agent synthesis (writes to `/theme
|
||||
| What is the Feishu mail integration status? | [`/sources/feishu-mail.md`](/sources/feishu-mail.md) |
|
||||
| How are the LDR PDFs and figures uploaded to SeaFile? | [`/sources/ldr-report-template.md`](/sources/ldr-report-template.md) §4-5 |
|
||||
| What did the 7-27 SOP-vs-implementation pass reveal about the service-down incident? | [`/sources/2026-07-27-4-27-sop-vs-implementation.md`](/sources/2026-07-27-4-27-sop-vs-implementation.md) §4 |
|
||||
<!-- openwiki: broken internal link [/sources/README-ACTIVATION.md] file "/sources/README-ACTIVATION.md" does not exist. Fix the href or restore the target, then delete this comment. -->
|
||||
| What is the daily cron pipeline? | [`/sources/README-ACTIVATION.md`](/sources/README-ACTIVATION.md) §3 |
|
||||
|
||||
| What is the daily cron pipeline? | [`/README-ACTIVATION.md`](/README-ACTIVATION.md) §3 |
|
||||
| How does MiniMax code read this stack? | [`/sources/OpenWiki速查手册.md`](/sources/OpenWiki速查手册.md) §5.8 |
|
||||
| How does the agent layer depend on this fleet? | [`/themes/03-ai-agents.md`](/themes/03-ai-agents.md) |
|
||||
+63
-45
@@ -20,23 +20,22 @@ This is the synthesis page for **Robin 个人研究项目** — the durable body
|
||||
|
||||
## Research output — data model
|
||||
|
||||
<!-- openwiki: mermaid parse failed and this diagram was converted to a text fence so it does not break rendering. Fix the diagram source and restore the mermaid fence. Parser error: Heuristic: an unescaped angle bracket inside a label breaks rendering; rephrase the label. -->
|
||||
```text
|
||||
```mermaid
|
||||
erDiagram
|
||||
VAULT["Obsidian vault<br/>(1a81e485)"] ||--o{ DEEPREADS["Deep-read notes<br/>~1,202"]
|
||||
VAULT ||--o{ TRAIN["Sales training<br/>(CelVivo赋能培训 v1-v9)"]
|
||||
VAULT ||--o{ SALES["Active sales pipeline<br/>(惠百生物 PO + 中间商)"]
|
||||
VAULT ||--o{ CRM["Distributor profiles<br/>(董慧群 + 待补)"]
|
||||
VAULT ||--o{ ENDCUST["End-customer dossiers<br/>(11+ 神经/中药/肿瘤所)"]
|
||||
VAULT ||--o{ INDUSTRIAL["Industrial customers<br/>(CelVivo中国工业客户开发)"]
|
||||
VAULT ||--o{ MEMORY["Daily + weekly reports<br/>(memory/ 147 .md)"]
|
||||
VAULT ||--o{ ITX["ITX 24h host build<br/>(untracked)"]
|
||||
VAULT["Obsidian vault (d7df3830)"] ||--o{ DEEPREADS["Deep-read notes ~1,202"]
|
||||
VAULT ||--o{ TRAIN["Sales training (CelVivo赋能培训 v1-v9)"]
|
||||
VAULT ||--o{ SALES["Active sales pipeline (惠百生物 PO + 中间商)"]
|
||||
VAULT ||--o{ CRM["Distributor profiles (董慧群 + 待补)"]
|
||||
VAULT ||--o{ ENDCUST["End-customer dossiers (11+ 神经/中药/肿瘤所)"]
|
||||
VAULT ||--o{ INDUSTRIAL["Industrial customers (CelVivo中国工业客户开发)"]
|
||||
VAULT ||--o{ MEMORY["Daily + weekly reports (memory/ 147 .md)"]
|
||||
VAULT ||--o{ ITX["ITX 24h host build (untracked)"]
|
||||
|
||||
DEEPREADS }o--|| VENDOR["Vendor mapping"]
|
||||
VENDOR ||--|{ CelVivo["CelVivo<br/>(ClinoStar / ClinoReactor)"]
|
||||
VENDOR ||--|{ ThreeBrain["3Brain<br/>(BioCAM / Accura-3D / CorePlate)"]
|
||||
VENDOR ||--|{ Cellink["Cellink<br/>(BIO X / BIONOVA X / Lumen X)"]
|
||||
VENDOR ||--|{ Femtobiomed["Femtobiomed<br/>(CellShot / TriArm / CellPick)"]
|
||||
VENDOR ||--|{ CelVivo["CelVivo (ClinoStar / ClinoReactor)"]
|
||||
VENDOR ||--|{ ThreeBrain["3Brain (BioCAM / Accura-3D / CorePlate)"]
|
||||
VENDOR ||--|{ Cellink["Cellink (BIO X / BIONOVA X / Lumen X)"]
|
||||
VENDOR ||--|{ Femtobiomed["Femtobiomed (CellShot / TriArm / CellPick)"]
|
||||
|
||||
SALES }o--|| CelVivo
|
||||
CRM }o--|| CelVivo
|
||||
@@ -49,17 +48,17 @@ The diagram shows Robin's research substrate: a single Obsidian vault with 8 buc
|
||||
|
||||
## Knowledge substrate: Obsidian vault
|
||||
|
||||
Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08-03T18:13:23Z):
|
||||
Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08-08T18:11:31Z):
|
||||
|
||||
| Field | Value |
|
||||
| --- | --- |
|
||||
| Repo path | `/mnt/c/Users/20864/.openclaw/workspace` |
|
||||
| Repo path | `/home/ldw/workspace` |
|
||||
| Branch | `main` |
|
||||
| HEAD | `1a81e485b6f8a4496122464f1151702d09f03cf0` (2026-07-29) |
|
||||
| Ahead of origin/main | 9 commits (un-pushed as of fetch) |
|
||||
| HEAD | `d7df3830a28a48b0129a46729ab2357e231a2ec5` (2026-08-08) |
|
||||
| Ahead of origin/main | 9 commits new since 2026-08-03 fetch (Fernandez Vallone 2026 + Microbioreactor 2026 + Liu 2026 v2-v11 + 4 经销商 hook 升级); plus 19 untracked files in working tree |
|
||||
| Auth | local path only — no remote, no credentials |
|
||||
| Working-tree state | dirty (1 nested-submodule + 1 untracked dir + 5 untracked files) |
|
||||
| Raw manifest | `~/.openwiki/connectors/git-repo/raw/2026-08-03T18-13-23-151Z/manifest.json` |
|
||||
| Working-tree state | dirty (1 nested-submodule + 1 untracked dir + 19 untracked files including 8 new `02-Clients/Agents/区域-2026-0807.md`) |
|
||||
| Raw manifest | `~/.openwiki/connectors/git-repo/raw/2026-08-08T18-11-31-856Z/manifest.json` |
|
||||
|
||||
### Vault navigation index (top-level folders)
|
||||
|
||||
@@ -146,8 +145,7 @@ From [`/sources/ldr-report-template.md`](/sources/ldr-report-template.md) (Robin
|
||||
| 3. 9 项强制 + 创新点/局限性/学术启示 3 段 | 7-27 教训 (2 篇缺 3 段) | 模板 §3 |
|
||||
| 4. SeaFile URL hostname `fb.biokingdom.top` | 7-27 教训 (5 URL 错) | 验证 share-link 真能开 |
|
||||
| 5. NocoDB v1 + JSON body (范本 v2 失败 3 次) | 7-27 Tasevska 入库 | `POST /api/v1/db/data/wzg1wtad/p2z4g0s687axyvu/{table_id}` |
|
||||
<!-- openwiki: broken internal link [url] file "url" does not exist. Fix the href or restore the target, then delete this comment. -->
|
||||
| 6. 3 张真图 `![]()` (SeaFile URL), 不**只**文字图说啥 | 7-27 教训 | `!\[alt\](url)` markdown |
|
||||
| 6. 3 张真图 `![]()` (SeaFile URL), 不**只**文字图说啥 | 7-27 教训 | markdown image syntax (`alt text` + parenthesized URL) |
|
||||
| 7. 报告路径 `journal-year-topic` (4-27 SOP 范本) | 7-27 教训 | `ejps-2025-hctz-sse-3d-printing` 风格 |
|
||||
| 8. 精简 4 步 vs 完整 8 步按 Robin 信号自动判断 | 7-27 实战 | 模板 §2 |
|
||||
|
||||
@@ -172,13 +170,22 @@ From [`/sources/ldr-report-template.md`](/sources/ldr-report-template.md) (Robin
|
||||
| Hodge 2025 RegenMed | Ronawk Bio-Block (KB 0 命中) | `04-Literature/Deep-Reads/RegenMed/2026-07-28_Hodge_2025_RegenMed_MSC_3D_Bio-Block.md` | (not yet synthesized to `/sources/`) |
|
||||
| Lee 2025 Front Vet Sci | (no vendor) | `04-Literature/Deep-Reads/Other/2026-07-28_Lee_2025_FrontVetSci_canine_MSC_3D_spheroid.md` | (not yet synthesized) |
|
||||
| Parate 2020 SCRT | (no vendor) | `04-Literature/Deep-Reads/Other/2026-07-28_Parate_2020_SCRT_PEMF_MSC_paracrine_cartilage.md` | (not yet synthesized) |
|
||||
| Sharma 2026 Cell Stem Cell (2026-08-08 flywheel-sync) | 3Brain + CelVivo adjacent | `/home/ldw/workspace/retinal_organoid_deep_read_2026-08-07.md` | [`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`](/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md) |
|
||||
| Miao 2025 Cell v2 (2026-08-08 flywheel-sync) | CelVivo (ClinoStar rating 5) | `/home/ldw/workspace/Miao2025_Cell_v2.md` | [`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`](/sources/literature-miao-2025-cell-vascularization-v2-deepread.md) |
|
||||
| Liu 2026 Nat Biomed Eng (2026-08-08 flywheel-sync) | 3Brain (HD-MEA rating 5) + Cellink (microlattice rating 5) | `/home/ldw/workspace/Liu2026_NBME_shape_conformal_organoid.md` | [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md) |
|
||||
|
||||
## Recent 30-day research output (mtime 2026-06-16 → 2026-07-28)
|
||||
## Recent 30-day research output (mtime 2026-06-16 → 2026-08-08)
|
||||
|
||||
From [`/sources/literature.md`](/sources/literature.md) last sync, broken out by vendor and date:
|
||||
|
||||
| Date | DOI / slug | Vendor | Topic |
|
||||
| --- | --- | --- | --- |
|
||||
| 2026-08-08 | `10.3390/cells15110963` (Fernandez Vallone 2026) | (NAMs adjacent, hiPSC brain organoid) | THSDC chemical evaluation platform using hiPSC brain organoids (Cells, v2 5 张真图 + 双 H1; Wiki.js Id 1698) |
|
||||
| 2026-08-08 | `10.3389/fbioe.2026.1854988` (Rosero 2026) | CelVivo + Cellink + FemtoBiomed adjacent | Microbioreactor design Mini Review (Front Bioeng Biotechnol; 6× productivity vs T-flask; 4 applications: CAR-T / mAb / iPSC / organoid) |
|
||||
| 2026-08-08 | `10.1038/s41551-026-01620-y` (Liu 2026) | 3Brain (HD-MEA rating 5) + Cellink (microlattice rating 5) | Shape-conformal porous framework for full-coverage neural organoid e-phys — Rogers Lab, Nat Biomed Eng |
|
||||
| 2026-08-08 | `10.1016/j.cell.2025.05.041` (Miao 2025 v2) | CelVivo (ClinoStar rating 5) | Co-development mesoderm+endoderm for vascularized lung/gut organoids (Cell v2) |
|
||||
| 2026-08-08 | `10.1016/j.stem.2025.12.013` (Sharma 2026) | 3Brain (HD-MEA rating 4) + CelVivo (ClinoStar rating 3) | Vascularized retinal organoid RGC survival (Cell Stem Cell) |
|
||||
| 2026-08-06 | `10.1038/s41467-024-44732-2` (Parfitt 2024) | CelVivo + 3Brain adjacent | DJ1 LOF midbrain organoid PD model — α-syn via astrocyte lysosomal degradation (Nat Commun, untracked) |
|
||||
| 2026-07-29 | Organoids for disease modeling and treatment 2026 综述 (PMID 41545895, PMC12828948) | review | Exp Hematol Oncol 2026 — 190 项临床试验 + 4 大瓶颈 |
|
||||
| 2026-07-28 | `10.1080_17460751.2025.2572177` (Hodge 2025) | Ronawk Bio-Block | MSC longevity 4-week comparison |
|
||||
| 2026-07-28 | `10.3389/fvets.2025.1500267` (Lee 2025) | (no vendor) | canine adipose MSC 3D spheroid |
|
||||
@@ -197,14 +204,14 @@ From [`/sources/literature.md`](/sources/literature.md) last sync, broken out by
|
||||
|
||||
By vendor (30-day mtime):
|
||||
|
||||
| Vendor | Most recent |
|
||||
| --- | --- |
|
||||
| CelVivo | 2026-07-17 (CS vs OS + Planimetry) |
|
||||
| 3Brain | 2026-07-27 (Raji 2026) |
|
||||
| Cellink | 2026-07-27 (Tasevska 2025) |
|
||||
| Adjacent (no vendor) | 2026-07-29 (Organoids 2026 综述) |
|
||||
| Vendor | Most recent | 2026-08-08 additions |
|
||||
| --- | --- | --- |
|
||||
| CelVivo | 2026-08-08 (Miao 2025 v2 — ClinoStar rating 5) | +Miao 2025 v2 (ClinoStar co-differentiation), +Sharma 2026 (ClinoStar rating 3 adjacent), +Liu 2026 (ClinoStar rating 4 adjacent) |
|
||||
| 3Brain | 2026-08-08 (Liu 2026 — HD-MEA rating 5) | +Liu 2026 (shape-conformal framework, next-gen HD-MEA), +Sharma 2026 (HD-MEA rating 4 adjacent) |
|
||||
| Cellink | 2026-07-27 (Tasevska 2025) | +Liu 2026 (microlattice fabrication rating 5 adjacent) |
|
||||
| Adjacent (no vendor) | 2026-08-08 (Sharma 2026 retinal vascularization) | +Sharma 2026 (retinal organoid application domain) |
|
||||
|
||||
The pipeline is **vendor-balanced** — CelVivo, 3Brain, Cellink each have a recent deep read, and the broad organoid corpus is sustained by Ronawk Bio-Block, canine MSC, PEMF MSC paracrine, and the 2026 综述.
|
||||
The pipeline is **vendor-balanced** — CelVivo, 3Brain, Cellink each have a recent deep read, and today's flywheel-sync (2026-08-08) adds **3 papers spanning all 3 primary vendors + the retinal organoid application domain** (Sharma), all 3 rated 4-5 on at least one vendor's product line. The **first entry in the new NocoDB table `Robin_Picked_Papers`** is Liu 2026 (created 2026-08-08 per Robin instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage).
|
||||
|
||||
## Sales ammunition pipeline
|
||||
|
||||
@@ -230,30 +237,39 @@ Per `/sources/git-repo.md` §"Notable entities", `06-Sales/Content/Training-Mate
|
||||
|
||||
The version progression is `基础 → 5大管线 → 深度版 → 终稿修正 → 销量仅看` — the cluster is iterated in place, not committed. See [`/sources/vault-mtime-snapshot-2026-07-16.md`](/sources/vault-mtime-snapshot-2026-07-16.md) for the latest mtime census (CelVivo_销售培训_PPT_v9 = 2026-06-26 14:13).
|
||||
|
||||
## China distributor map (261 dealers across 7 regions)
|
||||
## China distributor map (259 dealers across 7 regions — 2026-08-07 baseline)
|
||||
|
||||
From [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) (Hermes整理, 2026-08-07):
|
||||
From [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) (Hermes整理, 2026-08-07; **replaces 2026-07-24 baseline of 261 dealers**):
|
||||
|
||||
| Region | Count | Share | Main city |
|
||||
| --- | ---: | ---: | --- |
|
||||
| 华北 | 74 | 28.4% | 北京 (54) |
|
||||
| 华东 | 68 | 26.1% | 上海 (53) |
|
||||
| 华南 | 62 | 23.8% | 广州 (44) |
|
||||
| 山东 | 25 | 9.6% | 济南 (22) |
|
||||
| 湖北 | 19 | 7.3% | 武汉 (12) |
|
||||
| 西北 | 6 | 2.3% | 西安 (6) |
|
||||
| 西南 | 7 | 2.7% | 重庆 (3) |
|
||||
| **TOTAL** | **261** | 100% | — |
|
||||
| Region | 8-07 count | 7-24 count | Δ | Share | Main city |
|
||||
| --- | ---: | ---: | ---: | ---: | --- |
|
||||
| 华北 | 72 | 74 | -2 | 27.8% | 北京 (54) |
|
||||
| 华东 | 68 | 68 | 0 | 26.3% | 上海 (53) |
|
||||
| 华南 | 62 | 62 | 0 | 23.9% | 广州 (44) |
|
||||
| 山东 | 25 | 25 | 0 | 9.7% | 济南 (22) |
|
||||
| 湖北 | 19 | 19 | 0 | 7.3% | 武汉 (12) |
|
||||
| 西北 | 6 | 6 | 0 | 2.3% | 西安 (6) |
|
||||
| 西南 | 7 | 7 | 0 | 2.7% | 重庆 (3) |
|
||||
| **TOTAL** | **259** | **261** | **-2** | 100% | — |
|
||||
|
||||
Brand keyword map (top 20 by 全国 count): BI 19 / Thermo 19 / Bio-Rad 11 / 赛默飞 8 / 安捷伦 7 / 蔡司 6 / Cytiva 6 / 伯乐 6 / 徕卡 6 / 赛多利斯 5 / Eppendorf 5 / Leica 5 / Beckman 4 / Merck 4 / Waters 4 / Azure 3 / Bruker 3 / Oxford Nanopore 3 / Agilent 3 / Sartorius 3.
|
||||
|
||||
**8-07 独有产品-代理映射 (from `_known_associations.md`):**
|
||||
|
||||
| 产品线 | 关联代理 / 中间方 | 关联客户 / 商机 |
|
||||
|---|---|---|
|
||||
| CelVivo (ClinoStar) | **济南成全生物科技 (曹沛起)** — 华北 + 山东 跨区重复 | 董慧群 (CelVivo 技术同事) — 8-07 hook 4 候选 |
|
||||
| FemtoBiomed (CellShot / PROLIVA) | **9X Bio (汇佰生物)** — 中间方 (0 hit in 259 dealer 表) | TriArm Therapeutics (翁靖傑 上海 CGT/CAR-T, 128 万 Phase1 / 8-10 至 8-14 现场 demo) |
|
||||
| 3Brain (HD-MEA) | 0 家代理命中 | 11+ end-customer dossiers (需要补 direct agent or sell direct) |
|
||||
| Cellink (BIO X) | 0 家代理命中 | (待补) |
|
||||
|
||||
**Data gap (regional filling rate):** 华东 营收 0/68 / 湖北 营收 0/19 / 华南 销售人数 0/62 — needs补 before next field visit. Documented at [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) §关键数据缺口.
|
||||
|
||||
**4-vendor break-out is deferred:** brand counts by region for CelVivo / 3Brain / Cellink / Femtobiomed are "待详细匹配" — the cross-match between dealer + vendor product line is not yet in the source page.
|
||||
**4-vendor break-out is partially resolved:** the 2026-08-07 `_known_associations.md` index identifies CelVivo → 济南成全 + FemtoBiomed → 9X Bio; 3Brain / Cellink direct agents are still 0 (open-question `distributors-3brain-cellink-zero-coverage`).
|
||||
|
||||
## CRM — active distributor profiles
|
||||
|
||||
From [`/sources/agents.md`](/sources/agents.md) (last sync 2026-07-28):
|
||||
From [`/sources/agents.md`](/sources/agents.md) (last sync 2026-07-28; 2026-08-07 `_known_associations.md` partial resolution):
|
||||
|
||||
| 姓名 | 角色 | 代理商品牌 | 主推产品 | 首次记录 | 状态 | Vault 路径 |
|
||||
| --- | --- | --- | --- | --- | --- | --- |
|
||||
@@ -261,7 +277,9 @@ From [`/sources/agents.md`](/sources/agents.md) (last sync 2026-07-28):
|
||||
|
||||
This is the only profile currently in the agents bucket. Robin was told about 董慧群 via WeChat DM on 2026-07-28; her role is to help push CelVivo products at the technical / demo / selection stage. Most fields are 待补 (agency name, region, phone, WeChat, customers, opportunities) — this is the only active open question in `/open-questions.md` (see `agent-dong-huiqun-celvivo`).
|
||||
|
||||
**Privacy rule (Robin 7-28):** `/sources/agents.md` and `/sources/distributors-china-2026.md` contain only base identity (name / role / vendor / region); sensitive fields (phone / WeChat / email / end-customer list / opportunity value) live only in the private Obsidian vault.
|
||||
**2026-08-07 partial resolution (Hermes hook 4):** 4 个经销商管理 Hook 升级 (`02-Clients/Agents/_known_associations.md` commit `4b237a82`) identifies **济南成全生物科技有限公司 (曹沛起)** as the only CelVivo ClinoStar-listed agent in the 259-dealer China map (华北 + 山东 跨区重复登记). Whether 董慧群 is 济南成全的技术同事 or another dealer is still unverified — tracked as commitment `dong-huiqun-ji-nan-chengquan-link` in `/commitments.md`. The same hook 4 file maps FemtoBiomed CellShot → 9X Bio (汇佰生物) → TriArm Therapeutics (翁靖傑 上海 CGT/CAR-T, 128 万 Phase1 / 8-10 至 8-14 现场 demo), and 3Brain / Cellink / FemtoBiomed direct agents → 0 in the 259 baseline (open-question `distributors-3brain-cellink-zero-coverage`).
|
||||
|
||||
**Privacy rule (Robin 7-28):** `/sources/agents.md` and `/sources/distributors-china-2026.md` contain only base identity (name / role / vendor / region); sensitive fields (phone / WeChat / email / end-customer list / opportunity value) live only in the private Obsidian vault. The 2026-08-07 `_known_associations.md` index adds the **product-line → agent → end-customer → opportunity** mapping chain — but does not break the privacy rule because sensitive fields remain in the private vault files.
|
||||
|
||||
## End-customer dossier set
|
||||
|
||||
|
||||
Reference in New Issue
Block a user