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chore: daily update 2026-08-09

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@@ -20,23 +20,22 @@ This is the synthesis page for **Robin 个人研究项目** — the durable body
## Research output — data model
<!-- openwiki: mermaid parse failed and this diagram was converted to a text fence so it does not break rendering. Fix the diagram source and restore the mermaid fence. Parser error: Heuristic: an unescaped angle bracket inside a label breaks rendering; rephrase the label. -->
```text
```mermaid
erDiagram
VAULT["Obsidian vault<br/>(1a81e485)"] ||--o{ DEEPREADS["Deep-read notes<br/>~1,202"]
VAULT ||--o{ TRAIN["Sales training<br/>(CelVivo赋能培训 v1-v9)"]
VAULT ||--o{ SALES["Active sales pipeline<br/>(惠百生物 PO + 中间商)"]
VAULT ||--o{ CRM["Distributor profiles<br/>(董慧群 + 待补)"]
VAULT ||--o{ ENDCUST["End-customer dossiers<br/>(11+ 神经/中药/肿瘤所)"]
VAULT ||--o{ INDUSTRIAL["Industrial customers<br/>(CelVivo中国工业客户开发)"]
VAULT ||--o{ MEMORY["Daily + weekly reports<br/>(memory/ 147 .md)"]
VAULT ||--o{ ITX["ITX 24h host build<br/>(untracked)"]
VAULT["Obsidian vault (d7df3830)"] ||--o{ DEEPREADS["Deep-read notes ~1,202"]
VAULT ||--o{ TRAIN["Sales training (CelVivo赋能培训 v1-v9)"]
VAULT ||--o{ SALES["Active sales pipeline (惠百生物 PO + 中间商)"]
VAULT ||--o{ CRM["Distributor profiles (董慧群 + 待补)"]
VAULT ||--o{ ENDCUST["End-customer dossiers (11+ 神经/中药/肿瘤所)"]
VAULT ||--o{ INDUSTRIAL["Industrial customers (CelVivo中国工业客户开发)"]
VAULT ||--o{ MEMORY["Daily + weekly reports (memory/ 147 .md)"]
VAULT ||--o{ ITX["ITX 24h host build (untracked)"]
DEEPREADS }o--|| VENDOR["Vendor mapping"]
VENDOR ||--|{ CelVivo["CelVivo<br/>(ClinoStar / ClinoReactor)"]
VENDOR ||--|{ ThreeBrain["3Brain<br/>(BioCAM / Accura-3D / CorePlate)"]
VENDOR ||--|{ Cellink["Cellink<br/>(BIO X / BIONOVA X / Lumen X)"]
VENDOR ||--|{ Femtobiomed["Femtobiomed<br/>(CellShot / TriArm / CellPick)"]
VENDOR ||--|{ CelVivo["CelVivo (ClinoStar / ClinoReactor)"]
VENDOR ||--|{ ThreeBrain["3Brain (BioCAM / Accura-3D / CorePlate)"]
VENDOR ||--|{ Cellink["Cellink (BIO X / BIONOVA X / Lumen X)"]
VENDOR ||--|{ Femtobiomed["Femtobiomed (CellShot / TriArm / CellPick)"]
SALES }o--|| CelVivo
CRM }o--|| CelVivo
@@ -49,17 +48,17 @@ The diagram shows Robin's research substrate: a single Obsidian vault with 8 buc
## Knowledge substrate: Obsidian vault
Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08-03T18:13:23Z):
Snapshot from [`/sources/git-repo.md`](/sources/git-repo.md) (last fetch 2026-08-08T18:11:31Z):
| Field | Value |
| --- | --- |
| Repo path | `/mnt/c/Users/20864/.openclaw/workspace` |
| Repo path | `/home/ldw/workspace` |
| Branch | `main` |
| HEAD | `1a81e485b6f8a4496122464f1151702d09f03cf0` (2026-07-29) |
| Ahead of origin/main | 9 commits (un-pushed as of fetch) |
| HEAD | `d7df3830a28a48b0129a46729ab2357e231a2ec5` (2026-08-08) |
| Ahead of origin/main | 9 commits new since 2026-08-03 fetch (Fernandez Vallone 2026 + Microbioreactor 2026 + Liu 2026 v2-v11 + 4 经销商 hook 升级); plus 19 untracked files in working tree |
| Auth | local path only — no remote, no credentials |
| Working-tree state | dirty (1 nested-submodule + 1 untracked dir + 5 untracked files) |
| Raw manifest | `~/.openwiki/connectors/git-repo/raw/2026-08-03T18-13-23-151Z/manifest.json` |
| Working-tree state | dirty (1 nested-submodule + 1 untracked dir + 19 untracked files including 8 new `02-Clients/Agents/区域-2026-0807.md`) |
| Raw manifest | `~/.openwiki/connectors/git-repo/raw/2026-08-08T18-11-31-856Z/manifest.json` |
### Vault navigation index (top-level folders)
@@ -146,8 +145,7 @@ From [`/sources/ldr-report-template.md`](/sources/ldr-report-template.md) (Robin
| 3. 9 项强制 + 创新点/局限性/学术启示 3 段 | 7-27 教训 (2 篇缺 3 段) | 模板 §3 |
| 4. SeaFile URL hostname `fb.biokingdom.top` | 7-27 教训 (5 URL 错) | 验证 share-link 真能开 |
| 5. NocoDB v1 + JSON body (范本 v2 失败 3 次) | 7-27 Tasevska 入库 | `POST /api/v1/db/data/wzg1wtad/p2z4g0s687axyvu/{table_id}` |
<!-- openwiki: broken internal link [url] file "url" does not exist. Fix the href or restore the target, then delete this comment. -->
| 6. 3 张真图 `![]()` (SeaFile URL), 不**只**文字图说啥 | 7-27 教训 | `!\[alt\](url)` markdown |
| 6. 3 张真图 `![]()` (SeaFile URL), 不**只**文字图说啥 | 7-27 教训 | markdown image syntax (`alt text` + parenthesized URL) |
| 7. 报告路径 `journal-year-topic` (4-27 SOP 范本) | 7-27 教训 | `ejps-2025-hctz-sse-3d-printing` 风格 |
| 8. 精简 4 步 vs 完整 8 步按 Robin 信号自动判断 | 7-27 实战 | 模板 §2 |
@@ -172,13 +170,22 @@ From [`/sources/ldr-report-template.md`](/sources/ldr-report-template.md) (Robin
| Hodge 2025 RegenMed | Ronawk Bio-Block (KB 0 命中) | `04-Literature/Deep-Reads/RegenMed/2026-07-28_Hodge_2025_RegenMed_MSC_3D_Bio-Block.md` | (not yet synthesized to `/sources/`) |
| Lee 2025 Front Vet Sci | (no vendor) | `04-Literature/Deep-Reads/Other/2026-07-28_Lee_2025_FrontVetSci_canine_MSC_3D_spheroid.md` | (not yet synthesized) |
| Parate 2020 SCRT | (no vendor) | `04-Literature/Deep-Reads/Other/2026-07-28_Parate_2020_SCRT_PEMF_MSC_paracrine_cartilage.md` | (not yet synthesized) |
| Sharma 2026 Cell Stem Cell (2026-08-08 flywheel-sync) | 3Brain + CelVivo adjacent | `/home/ldw/workspace/retinal_organoid_deep_read_2026-08-07.md` | [`/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md`](/sources/literature-sharma-2026-cell-stem-cell-vascularized-retinal-organoid-rgc-deepread.md) |
| Miao 2025 Cell v2 (2026-08-08 flywheel-sync) | CelVivo (ClinoStar rating 5) | `/home/ldw/workspace/Miao2025_Cell_v2.md` | [`/sources/literature-miao-2025-cell-vascularization-v2-deepread.md`](/sources/literature-miao-2025-cell-vascularization-v2-deepread.md) |
| Liu 2026 Nat Biomed Eng (2026-08-08 flywheel-sync) | 3Brain (HD-MEA rating 5) + Cellink (microlattice rating 5) | `/home/ldw/workspace/Liu2026_NBME_shape_conformal_organoid.md` | [`/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md`](/sources/literature-liu-2026-nbme-shape-conformal-organoid-deepread.md) |
## Recent 30-day research output (mtime 2026-06-16 → 2026-07-28)
## Recent 30-day research output (mtime 2026-06-16 → 2026-08-08)
From [`/sources/literature.md`](/sources/literature.md) last sync, broken out by vendor and date:
| Date | DOI / slug | Vendor | Topic |
| --- | --- | --- | --- |
| 2026-08-08 | `10.3390/cells15110963` (Fernandez Vallone 2026) | (NAMs adjacent, hiPSC brain organoid) | THSDC chemical evaluation platform using hiPSC brain organoids (Cells, v2 5 张真图 + 双 H1; Wiki.js Id 1698) |
| 2026-08-08 | `10.3389/fbioe.2026.1854988` (Rosero 2026) | CelVivo + Cellink + FemtoBiomed adjacent | Microbioreactor design Mini Review (Front Bioeng Biotechnol; 6× productivity vs T-flask; 4 applications: CAR-T / mAb / iPSC / organoid) |
| 2026-08-08 | `10.1038/s41551-026-01620-y` (Liu 2026) | 3Brain (HD-MEA rating 5) + Cellink (microlattice rating 5) | Shape-conformal porous framework for full-coverage neural organoid e-phys — Rogers Lab, Nat Biomed Eng |
| 2026-08-08 | `10.1016/j.cell.2025.05.041` (Miao 2025 v2) | CelVivo (ClinoStar rating 5) | Co-development mesoderm+endoderm for vascularized lung/gut organoids (Cell v2) |
| 2026-08-08 | `10.1016/j.stem.2025.12.013` (Sharma 2026) | 3Brain (HD-MEA rating 4) + CelVivo (ClinoStar rating 3) | Vascularized retinal organoid RGC survival (Cell Stem Cell) |
| 2026-08-06 | `10.1038/s41467-024-44732-2` (Parfitt 2024) | CelVivo + 3Brain adjacent | DJ1 LOF midbrain organoid PD model — α-syn via astrocyte lysosomal degradation (Nat Commun, untracked) |
| 2026-07-29 | Organoids for disease modeling and treatment 2026 综述 (PMID 41545895, PMC12828948) | review | Exp Hematol Oncol 2026 — 190 项临床试验 + 4 大瓶颈 |
| 2026-07-28 | `10.1080_17460751.2025.2572177` (Hodge 2025) | Ronawk Bio-Block | MSC longevity 4-week comparison |
| 2026-07-28 | `10.3389/fvets.2025.1500267` (Lee 2025) | (no vendor) | canine adipose MSC 3D spheroid |
@@ -197,14 +204,14 @@ From [`/sources/literature.md`](/sources/literature.md) last sync, broken out by
By vendor (30-day mtime):
| Vendor | Most recent |
| --- | --- |
| CelVivo | 2026-07-17 (CS vs OS + Planimetry) |
| 3Brain | 2026-07-27 (Raji 2026) |
| Cellink | 2026-07-27 (Tasevska 2025) |
| Adjacent (no vendor) | 2026-07-29 (Organoids 2026 综述) |
| Vendor | Most recent | 2026-08-08 additions |
| --- | --- | --- |
| CelVivo | 2026-08-08 (Miao 2025 v2 — ClinoStar rating 5) | +Miao 2025 v2 (ClinoStar co-differentiation), +Sharma 2026 (ClinoStar rating 3 adjacent), +Liu 2026 (ClinoStar rating 4 adjacent) |
| 3Brain | 2026-08-08 (Liu 2026 — HD-MEA rating 5) | +Liu 2026 (shape-conformal framework, next-gen HD-MEA), +Sharma 2026 (HD-MEA rating 4 adjacent) |
| Cellink | 2026-07-27 (Tasevska 2025) | +Liu 2026 (microlattice fabrication rating 5 adjacent) |
| Adjacent (no vendor) | 2026-08-08 (Sharma 2026 retinal vascularization) | +Sharma 2026 (retinal organoid application domain) |
The pipeline is **vendor-balanced** — CelVivo, 3Brain, Cellink each have a recent deep read, and the broad organoid corpus is sustained by Ronawk Bio-Block, canine MSC, PEMF MSC paracrine, and the 2026 综述.
The pipeline is **vendor-balanced** — CelVivo, 3Brain, Cellink each have a recent deep read, and today's flywheel-sync (2026-08-08) adds **3 papers spanning all 3 primary vendors + the retinal organoid application domain** (Sharma), all 3 rated 4-5 on at least one vendor's product line. The **first entry in the new NocoDB table `Robin_Picked_Papers`** is Liu 2026 (created 2026-08-08 per Robin instruction to capture papers Robin hand-picks / provides outside the regular PubMed triage).
## Sales ammunition pipeline
@@ -230,30 +237,39 @@ Per `/sources/git-repo.md` §"Notable entities", `06-Sales/Content/Training-Mate
The version progression is `基础 → 5大管线 → 深度版 → 终稿修正 → 销量仅看` — the cluster is iterated in place, not committed. See [`/sources/vault-mtime-snapshot-2026-07-16.md`](/sources/vault-mtime-snapshot-2026-07-16.md) for the latest mtime census (CelVivo_销售培训_PPT_v9 = 2026-06-26 14:13).
## China distributor map (261 dealers across 7 regions)
## China distributor map (259 dealers across 7 regions — 2026-08-07 baseline)
From [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) (Hermes整理, 2026-08-07):
From [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) (Hermes整理, 2026-08-07; **replaces 2026-07-24 baseline of 261 dealers**):
| Region | Count | Share | Main city |
| --- | ---: | ---: | --- |
| 华北 | 74 | 28.4% | 北京 (54) |
| 华东 | 68 | 26.1% | 上海 (53) |
| 华南 | 62 | 23.8% | 广州 (44) |
| 山东 | 25 | 9.6% | 济南 (22) |
| 湖北 | 19 | 7.3% | 武汉 (12) |
| 西北 | 6 | 2.3% | 西安 (6) |
| 西南 | 7 | 2.7% | 重庆 (3) |
| **TOTAL** | **261** | 100% | — |
| Region | 8-07 count | 7-24 count | Δ | Share | Main city |
| --- | ---: | ---: | ---: | ---: | --- |
| 华北 | 72 | 74 | -2 | 27.8% | 北京 (54) |
| 华东 | 68 | 68 | 0 | 26.3% | 上海 (53) |
| 华南 | 62 | 62 | 0 | 23.9% | 广州 (44) |
| 山东 | 25 | 25 | 0 | 9.7% | 济南 (22) |
| 湖北 | 19 | 19 | 0 | 7.3% | 武汉 (12) |
| 西北 | 6 | 6 | 0 | 2.3% | 西安 (6) |
| 西南 | 7 | 7 | 0 | 2.7% | 重庆 (3) |
| **TOTAL** | **259** | **261** | **-2** | 100% | — |
Brand keyword map (top 20 by 全国 count): BI 19 / Thermo 19 / Bio-Rad 11 / 赛默飞 8 / 安捷伦 7 / 蔡司 6 / Cytiva 6 / 伯乐 6 / 徕卡 6 / 赛多利斯 5 / Eppendorf 5 / Leica 5 / Beckman 4 / Merck 4 / Waters 4 / Azure 3 / Bruker 3 / Oxford Nanopore 3 / Agilent 3 / Sartorius 3.
**8-07 独有产品-代理映射 (from `_known_associations.md`):**
| 产品线 | 关联代理 / 中间方 | 关联客户 / 商机 |
|---|---|---|
| CelVivo (ClinoStar) | **济南成全生物科技 (曹沛起)** — 华北 + 山东 跨区重复 | 董慧群 (CelVivo 技术同事) — 8-07 hook 4 候选 |
| FemtoBiomed (CellShot / PROLIVA) | **9X Bio (汇佰生物)** — 中间方 (0 hit in 259 dealer 表) | TriArm Therapeutics (翁靖傑 上海 CGT/CAR-T, 128 万 Phase1 / 8-10 至 8-14 现场 demo) |
| 3Brain (HD-MEA) | 0 家代理命中 | 11+ end-customer dossiers (需要补 direct agent or sell direct) |
| Cellink (BIO X) | 0 家代理命中 | (待补) |
**Data gap (regional filling rate):** 华东 营收 0/68 / 湖北 营收 0/19 / 华南 销售人数 0/62 — needs补 before next field visit. Documented at [`/sources/distributors-china-2026.md`](/sources/distributors-china-2026.md) §关键数据缺口.
**4-vendor break-out is deferred:** brand counts by region for CelVivo / 3Brain / Cellink / Femtobiomed are "待详细匹配" — the cross-match between dealer + vendor product line is not yet in the source page.
**4-vendor break-out is partially resolved:** the 2026-08-07 `_known_associations.md` index identifies CelVivo → 济南成全 + FemtoBiomed → 9X Bio; 3Brain / Cellink direct agents are still 0 (open-question `distributors-3brain-cellink-zero-coverage`).
## CRM — active distributor profiles
From [`/sources/agents.md`](/sources/agents.md) (last sync 2026-07-28):
From [`/sources/agents.md`](/sources/agents.md) (last sync 2026-07-28; 2026-08-07 `_known_associations.md` partial resolution):
| 姓名 | 角色 | 代理商品牌 | 主推产品 | 首次记录 | 状态 | Vault 路径 |
| --- | --- | --- | --- | --- | --- | --- |
@@ -261,7 +277,9 @@ From [`/sources/agents.md`](/sources/agents.md) (last sync 2026-07-28):
This is the only profile currently in the agents bucket. Robin was told about 董慧群 via WeChat DM on 2026-07-28; her role is to help push CelVivo products at the technical / demo / selection stage. Most fields are 待补 (agency name, region, phone, WeChat, customers, opportunities) — this is the only active open question in `/open-questions.md` (see `agent-dong-huiqun-celvivo`).
**Privacy rule (Robin 7-28):** `/sources/agents.md` and `/sources/distributors-china-2026.md` contain only base identity (name / role / vendor / region); sensitive fields (phone / WeChat / email / end-customer list / opportunity value) live only in the private Obsidian vault.
**2026-08-07 partial resolution (Hermes hook 4):** 4 个经销商管理 Hook 升级 (`02-Clients/Agents/_known_associations.md` commit `4b237a82`) identifies **济南成全生物科技有限公司 (曹沛起)** as the only CelVivo ClinoStar-listed agent in the 259-dealer China map (华北 + 山东 跨区重复登记). Whether 董慧群 is 济南成全的技术同事 or another dealer is still unverified — tracked as commitment `dong-huiqun-ji-nan-chengquan-link` in `/commitments.md`. The same hook 4 file maps FemtoBiomed CellShot → 9X Bio (汇佰生物) → TriArm Therapeutics (翁靖傑 上海 CGT/CAR-T, 128 万 Phase1 / 8-10 至 8-14 现场 demo), and 3Brain / Cellink / FemtoBiomed direct agents → 0 in the 259 baseline (open-question `distributors-3brain-cellink-zero-coverage`).
**Privacy rule (Robin 7-28):** `/sources/agents.md` and `/sources/distributors-china-2026.md` contain only base identity (name / role / vendor / region); sensitive fields (phone / WeChat / email / end-customer list / opportunity value) live only in the private Obsidian vault. The 2026-08-07 `_known_associations.md` index adds the **product-line → agent → end-customer → opportunity** mapping chain — but does not break the privacy rule because sensitive fields remain in the private vault files.
## End-customer dossier set